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MicroRNAs and early detection

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https://www.readbyqxmd.com/read/29676832/circulating-mirnas-in-acute-new-onset-atrial-fibrillation-and-their-target-mrna-network
#1
Ananília Medeiros Gomes da Silva, Jéssica Nayara Góes de Araújo, Katiene Macêdo de Oliveira, Ana Eloísa Melo Novaes, Mariana Borges Lopes, Júlio César Vieira de Sousa, Antônio Amorim de Araújo Filho, André Ducati Luchessi, Adriana Augusto de Rezende, Mário Hiroyuki Hirata, Vivian Nogueira Silbiger
BACKGROUND: MicroRNAs (miRNAs) are involved in the pathogenesis of atrial fibrillation (AF), acting on development and progression. Our pilot study investigated the expression of six miRNAs and their miRNA-mRNA interactions in patients with acute new-onset AF, well-controlled AF, and normal sinus rhythm (controls). METHODS AND RESULTS: Plasma of acute new-onset AF patients (n = 5) was collected in the emergency room when patients presented with irregular and fast-atrial fibrillation rhythm...
April 20, 2018: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29675163/imaging-multiple-micrornas-in-living-cells-using-atp-self-powered-strand-displacement-cascade-amplification
#2
Xiangdan Meng, Wenhao Dai, Kai Zhang, Haifeng Dong, Xueji Zhang
Herein, we design a smart autonomous ATP self-powered strand-displacement cascade amplification (SDCA) system for highly sensitive multiple intracellular miRNA detection. Rationally engineered Y-motif DNA structures are functionalized on mesoporous silica-coated copper sulfide nanoparticles loaded with numerous ATPs (CuS@mSiO2 -Y/ATP) through pH stimulus-responsive disulfide bonds. The SDCA system is implemented by endogenous specific miRNA as a trigger and ATP as fuel released from the nanocarrier at acidic pH and photothermal stimuli-responsive CuS...
February 7, 2018: Chemical Science
https://www.readbyqxmd.com/read/29666782/new-perspectives-on-diagnosis-and-therapy-of-malignant-pleural-mesothelioma
#3
REVIEW
Marika Rossini, Paola Rizzo, Ilaria Bononi, Anthony Clementz, Roberto Ferrari, Fernanda Martini, Mauro G Tognon
Malignant pleural mesothelioma (MPM) is a rare, but severe form of cancer, with an incidence that varies significantly within and among different countries around the world. It develops in about one to two persons per million of the general population, leading to thousands of deaths every year worldwide. To date, the MPM is mostly associated with occupational asbestos exposure. Asbestos represents the predominant etiological factor, with approximately 70% of cases of MPM with well-documented occupational exposure to asbestos, with the exposure time, on average greater than 40 years...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29658967/identification-of-microrna-signature-in-different-pediatric-brain-tumors
#4
Marwa Tantawy, Mariam G Elzayat, Dina Yehia, Hala Taha
Understanding pediatric brain tumor biology is essential to help on disease stratification, and to find novel markers for early diagnosis. MicroRNA (miRNA) expression has been linked to clinical outcomes and tumor biology. Here, we aimed to detect the expression of different miRNAs in different pediatric brain tumor subtypes to discover biomarkers for early detection and develop novel therapies. Expression of 82 miRNAs was detected in 120 pediatric brain tumors from fixed-formalin paraffin-embedded tissues, low-grade glioma, high-grade glioma, ependymoma, and medulloblastoma, using quantitative real-time PCR...
January 2018: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/29658868/serum-levels-of-mir-155-mir-326-and-mir-133b-as-early-diagnostic-biomarkers-for-the-detection-of-human-acute-heart-allograft-rejection-in-comparison-with-serum-cardiac-troponin-t
#5
Aghil Esmaeili-Bandboni, Jamshid Bagheri, Ali Reza Bakhshandeh, Javad Mohammadnejad, Esmaeil Sadroddiny
BACKGROUND: Acute heart allograft rejection occurs as a result of antibody-mediated rejection that presents during the first month after transplantation. Finding a non-invasive biomarker is essential for diagnosis of heart allograft rejection. In this research, we intended to compare expression levels of several microRNAs across cardiac troponin T levels between rejected patients (who died before one month following transplantation), non-rejected patients (who survived for at least one month after transplantation), and non-transplanted patients (CABG surgery patients)...
March 12, 2018: Heart Surgery Forum
https://www.readbyqxmd.com/read/29658562/microrna%C3%A2-34a-mediates-atrial-fibrillation-through-regulation-of-ankyrin%C3%A2-b-expression
#6
Yun Zhu, Zezhou Feng, Wei Cheng, Yingbin Xiao
Atrial fibrillation (AF) has a high prevalence and recurrence rate, and is associated with substantial mortality. However, its underlying mechanisms are not thoroughly understood. Increasing attention has been paid to the roles of microRNAs (miRs) in the pathogenesis of cardiovascular disease, including miR‑1 and miR‑133 (in the electrophysiological response), and miR‑34a (in cardiac fibrosis). Recently, Ankyrin‑B (Ank‑B), an adaptor protein, has been demonstrated to be associated with AF. As a predicted target gene of miR‑34a, the present study aimed to investigate if miR‑34a has a role in AF via regulation of Ank‑B expression...
April 12, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29627835/diagnosis-of-hyperacute-and-acute-ischaemic-stroke-the-potential-utility-of-exosomal-microrna-21-5p-and-microrna-30a-5p
#7
Wei Wang, Dong-Bin Li, Ru-Ying Li, Xia Zhou, Dong-Ju Yu, Xiao-Yan Lan, Jin-Pin Li, Jing-Li Liu
BACKGROUND: Early and accurate diagnosis of ischaemic stroke (IS) requires the use of an optimized biomarker. Exosomal microRNAs have the potential to serve as biomarkers owing to their stability and specificity. We investigated the expression levels of plasma-derived exosomal microRNA-21-5p and microRNA-30a-5p in the different phases of IS. METHODS: One hundred forty-three patients with IS and 24 non-stroke controls were enrolled. The patients were divided into the following 5 groups: 1 group for the hyperacute phase IS (HIS, within 6 h); two for the acute phase IS (AIS, including days 1-3 and days 4-7); one for the subacute phase IS (SIS, days 8-14); and one for the recovery phase IS (RIS, days >14)...
April 6, 2018: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/29616415/host-serum-microrna-profiling-during-the-early-stage-of-foot-and-mouth-disease-virus-infection
#8
Suresh H Basagoudanavar, Madhusudan Hosamani, R P Tamil Selvan, B P Sreenivasa, Aniket Sanyal, R Venkataramanan
Foot-and-mouth disease virus (FMDV) causes a highly contagious infection in cloven-hoofed animals, with many outbreaks in the developing world. MicroRNAs (miRNAs) are non-coding RNAs that regulate antiviral defence by post-transcriptional regulation of gene expression. In this study, the host miRNA response following FMDV infection was investigated in cattle, a natural host for FMDV. A significant alteration in serum miRNA expression was detected at early stages of infection. Compared to prior to infection, on day 2 postinfection (PI), 119 miRNAs were upregulated, of which 39 were significantly upregulated (P < 0...
April 3, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29607263/breast-cancer-identification-via-modeling-of-peripherally-circulating-mirnas
#9
Xiaomeng Cui, Zhangming Li, Yilei Zhao, Anqi Song, Yunbo Shi, Xin Hai, Wenliang Zhu
Prolonged life expectancy in humans has been accompanied by an increase in the prevalence of cancers. Breast cancer (BC) is the leading cause of cancer-related deaths. It accounts for one-fourth of all diagnosed cancers and affects one in eight females worldwide. Given the high BC prevalence, there is a practical need for demographic screening of the disease. In the present study, we re-analyzed a large microRNA (miRNA) expression dataset (GSE73002), with the goal of optimizing miRNA biomarker selection using neural network cascade (NNC) modeling...
2018: PeerJ
https://www.readbyqxmd.com/read/29605388/emerging-actors-in-diabetic-cardiomyopathy-heartbreaker-biomarkers-or-therapeutic-targets
#10
REVIEW
Xavier Palomer, Javier Pizarro-Delgado, Manuel Vázquez-Carrera
The diabetic heart is characterized by metabolic disturbances that are often accompanied by local inflammation, oxidative stress, myocardial fibrosis, and cardiomyocyte apoptosis. Overall changes result in contractile dysfunction, concentric left ventricular (LV) hypertrophy, and dilated cardiomyopathy, that together affect cardiac output and eventually lead to heart failure, the foremost cause of death in diabetic patients. There are currently several validated biomarkers for the diagnosis and risk assessment of cardiac diseases, but none is capable of discriminating patients with diabetic cardiomyopathy (DCM)...
March 28, 2018: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/29601337/future-of-liquid-biopsies-with-growing-technological-and-bioinformatics-studies-opportunities-and-challenges-in-discovering-tumor-heterogeneity-with-single-cell-level-analysis
#11
Naveen Ramalingam, Stefanie S Jeffrey
Liquid biopsy provides minimally invasive and readily obtainable access to tumor-associated biological material in blood or other body fluids. These samples provide important insights into cancer biology, such as primary tumor heterogeneity; real-time tumor evolution; response to therapy, including immunotherapy; and mechanisms of cancer metastasis. Initial biological materials studied were circulating tumor cells and circulating nucleic acids, including circulating tumor DNA and microRNAs; more recently, studies have expanded to investigate extracellular vesicles, such as exosomes, microvesicles, and large oncosomes; tumor-derived circulating endothelial cells; and tumor-educated platelets...
March 2018: Cancer Journal
https://www.readbyqxmd.com/read/29599914/serum-micrornas-as-predictors-of-risk-for-non-muscle-invasive-bladder-cancer
#12
Jie Lian, Shu-Hong Lin, Yuanqing Ye, David W Chang, Maosheng Huang, Colin P Dinney, Xifeng Wu
MicroRNAs (miRNAs) are implicated in the development of nearly all cancers and may function as promising biomarkers for early detection, diagnosis and prognosis. We sought to investigate the role of serum miRNAs as potential diagnostic biomarkers or biomarkers of risk for early-stage bladder cancer. First, we profiled global serum miRNAs in a pilot set of 10 non-muscle invasive bladder cancer (NMIBC) cases and 10 healthy controls matched on age, gender and smoking status. Eighty nine stably detectable miRNAs were selected for further testing and quantification by high-throughput Taqman analysis using the Fluidigm BioMark HD System to assess their association with NMIBC risk in both discovery and validation sets totaling 280 cases and 278 controls...
March 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/29599829/microrna-10b-expression-and-its-correlation-with-molecular-subtypes-of-early-invasive-ductal-carcinoma
#13
Chenming Guo, Minggang Fu, Yilamu Dilimina, Sha Liu, Liying Guo
The present study aimed to determine whether the expression of microRNA (miR)-10b was correlated with the molecular subtypes of early invasive ductal carcinoma of the breast. In situ hybridization was used to detect the expression of miR-10b in 193 patients diagnosed with early invasive ductal carcinoma. Immunohistochemistry was performed to evaluate the expression of estrogen receptor (ER)-α, progesterone receptor (PR) and human epidermal growth factor receptor-2 (Her-2). The positive expression rate of miR-10b in patients with early invasive ductal carcinoma with ER-α (+) or PR (+) was decreased compared with ER-α (-) or PR (-) patients (P<0...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29597259/the-role-of-circulating-free-dna-and-microrna-in-non-invasive-diagnosis-of-hbv-and-hcv-related-hepatocellular-carcinoma
#14
REVIEW
Francesca Pezzuto, Luigi Buonaguro, Franco Maria Buonaguro, Maria Lina Tornesello
Hepatocellular carcinoma (HCC) is the third and the fifth leading cause of cancer related death worldwide in men and in women, respectively. HCC generally has a poor prognosis, with a very low 5-year overall survival, due to delayed diagnosis and treatment. Early tumour detection and timely intervention are the best strategies to reduce morbidity and mortality in HCC patients. Histological evaluation of liver biopsies is the gold standard for cancer diagnosis, although it is an invasive, time-consuming and expensive procedure...
March 28, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29568911/mir-25-enhances-cell-migration-and-invasion-in-non-small-cell-lung-cancer-cells-via-erk-signaling-pathway-by-inhibiting-klf4
#15
Xiaoli Ding, Tianyu Zhong, Lixia Jiang, Junyun Huang, Yu Xia, Rong Hu
In recent years, microRNAs (miRNAs/miRs) have gained increasing interest in cancer research. Increasing evidences demonstrated that miRNAs are important for tumor early detection and prognosis. The present study aimed to explore the function of miR‑25 in non‑small‑cell lung cancer (NSCLC) and its underlying mechanisms. The expression levels of miR‑25 and Krüppel-like factor 4 (KLF4) were assessed in 31 pairs of tissue from patients with NSCLC. In addition, the biological roles of miR‑25 in NSCLC were analyzed via a cell wound healing assay, Transwell invasion and migration assays...
March 16, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29565037/circular-noncoding-rnas-as-potential-therapies-and-circulating-biomarkers-for-cardiovascular-diseases
#16
REVIEW
Ahmed S Bayoumi, Tatsuya Aonuma, Jian-Peng Teoh, Yao-Liang Tang, Il-Man Kim
Recent advancements in genome-wide analyses and RNA-sequencing technologies led to the discovery of small noncoding RNAs, such as microRNAs (miRs), as well as both linear long noncoding RNAs (lncRNAs) and circular long noncoding RNAs (circRNAs). The importance of miRs and lncRNAs in the treatment, prognosis and diagnosis of cardiovascular diseases (CVDs) has been extensively reported. We also previously reviewed their implications in therapies and as biomarkers for CVDs. More recently, circRNAs have also emerged as important regulators in CVDs...
March 22, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29556316/tumor-suppressor-microrna-136-5p-regulates-the-cellular-function-of-renal-cell-carcinoma
#17
Peijie Chen, Liwen Zhao, Xiang Pan, Lu Jin, Canbin Lin, Weijie Xu, Jinling Xu, Xin Guan, Xueling Wu, Yong Wang, Shangqi Yang, Tao Wang, Yongqing Lai
MicroRNAs (miRs) are involved in diverse physiological and developmental processes at the post-transcriptional level in cells. Previous studies have demonstrated that miR-136-5p is involved in certain types of cancer. However, the function of miR-136-5p in renal cell carcinoma (RCC) remains to be fully elucidated. In present study, miR-136-5p expression levels were determined by reverse transcription-quantitative polymerase chain reaction (RT-qPCR), and MTT assays, CCK-8 assays, Transwell assays, wound healing assays and flow cytometry were performed to investigate the function of miR-136-5p in RCC...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29552778/expression-of-mirna-137-in-oral-squamous-cell-carcinoma-and-its-clinical-significance
#18
Chen Sun, Jianxia Li
PURPOSE: To investigate the expression of microRNA (miRNA-137) in oral squamous cell carcinoma (OSCC) and its effects on activity, invasion and proliferation of OSCC human squamous cell carcinoma cell lines 2 (HSC-2 cell line). METHODS: 158 cases of pathologically-confirmed OSCC tissues and corresponding para-cancerous tissues were collected. The tissue mRNA was extracted and miRNA-137 expression in tissues was detected using real-time polymerase chain reaction (RT-PCR)...
January 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29552756/correlation-between-mir-21-and-mir-145-and-the-incidence-and-prognosis-of-colorectal-cancer
#19
Qing Liu, Weili Yang, Yongsheng Luo, Shuangcheng Hu, Linchang Zhu
PURPOSE: The purpose of this study was to investigate the expression of microRNA (miR)-21 and miR-145 in serum and tumor tissues of patients with colorectal cancer (CRC), and to explore the correlation between the expression of these miRs and the clinicopathological parameters and prognosis of CRC patients. METHODS: Serum specimens, frozen tumor tissue and adjacent normal tissue of 50 CRC patients who were hospitalized in our hospital from February 2009 to February 2011 were collected, along with serum specimens of 30 healthy people (control)...
January 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29540511/transmission-of-microrna-antimirs-to-mouse-offspring-via-the-maternal-placental-fetal-unit
#20
Jonas Hönig, Ivana Mižíková, Claudio Nardiello, David Emanuel Surate Solaligue, Maximilian J Daume, István Vadász, Konstantin Mayer, Susanne Herold, Stefan Günther, Werner Seeger, Rory Edward Morty
The emergence of microRNA as regulators of organogenesis and tissue differentiation has stimulated interest in the ablation of microRNA expression and function during discrete periods of development. To this end, inducible, conditional modulation of microRNA expression with doxycycline-based tetracycline-controlled transactivator and tamoxifen-based estrogen receptor systems has found widespread use. However, the induction agents and components of genome recombination systems negatively impact pregnancy, parturition, and post natal development; thereby limiting the use of these technologies between late gestation and the early post-natal period...
March 14, 2018: RNA
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