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MicroRNAs and early detection

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https://www.readbyqxmd.com/read/29050322/microrna-466-with-tumor-markers-for-cervical-cancer-screening
#1
Li-Li Zhou, Yong Shen, Jiao-Mei Gong, Ping Sun, Jia-He Sheng
Cervical cancer is the second most common cancer in women in the world. In this study, we explore tumor markers and microRNA-466 combination for cervical cancer screening. Tumor markers were measured by the methods of electro-chemiluminescent immunoassay and enzyme immunoassay. The microRNA-466 was performed by quantitative real-time polymerase chain reaction. Among normal group, hyperplasia group and cancer group, the CEA expression levels were 2.26 ng/ml, 3.85 ng/ml and 16.08 ng/ml, respectively. While the CA125 expression levels were 13...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29046702/in-vivo-validation-of-metastasis-regulating-microrna-766-in-human-triple-negative-breast-cancer-cells
#2
Keunhee Oh, Dong-Sup Lee
Breast cancer is the second most common cancer and the most frequent cancer in women worldwide. Recent improvements in early detection and effective adjuvant chemotherapies have improved the survival of breast cancer patients. Even with initial disease remission, one-third of all breast cancer patients will relapse with distant metastasis. Breast cancer metastasis is largely an incurable disease and the main cause of death among breast cancer patients. Cancer metastasis is comprised of complex processes that are usually not controllable by intervention of a single molecular target...
September 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/29042291/micrornas-as-biomarkers-for-liver-injury-current-knowledge-challenges-and-future-prospects
#3
REVIEW
Haixia Lin, Laura E Ewing, Igor Koturbash, Bill J Gurley, Isabelle R Miousse
MicroRNAs (miRNAs) are short regulatory RNAs that are involved in various biological processes that regulate gene expression posttranscriptionally. Changes in miRNA expression can be detected in many physiological and pathological events, such as liver injury. Drug induced liver injury is a life threatening condition that frequently requires organ transplantation. Hepatotoxicity is also one of the major causes of drug failure in clinical trials and of drug withdrawal from the market. The profiling of miRNA expression shows great promise in monitoring liver injury, in the prediction of outcome in patients, and in the identification of liver-reactive compounds in toxicological assessment...
October 14, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29038788/urinary-exosomal-microrna-profiling-in-incipient-type-2-diabetic-kidney-disease
#4
Yijun Xie, Yijie Jia, Xie Cuihua, Fang Hu, Meng Xue, Yaoming Xue
BACKGROUND: Albuminuria is an early sign but not a strong predictor of diabetic kidney disease (DKD). Owing to their high stability, urinary exosomal miRNAs can be useful predictors of the progression of early-stage DKD to renal failure; fluid biopsies are ideal for detecting abnormalities in these miRNAs. The aim of this study was to identify novel differentially expressed miRNAs as urine biomarkers for type 2 DKD by comparing between patients of type 2 diabetes (T2D) with and without macroalbuminuria...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29038786/micrornas-as-biomarkers-in-thyroid-carcinoma
#5
REVIEW
Marilena Celano, Francesca Rosignolo, Valentina Maggisano, Valeria Pecce, Michelangelo Iannone, Diego Russo, Stefania Bulotta
Optimal management of patients with thyroid cancer requires the use of sensitive and specific biomarkers. For early diagnosis and effective follow-up, the currently available cytological and serum biomarkers, thyroglobulin and calcitonin, present severe limitations. Research on microRNA expression in thyroid tumors is providing new insights for the development of novel biomarkers that can be used to diagnose thyroid cancer and optimize its management. In this review, we will examine some of the methods commonly used to detect and quantify microRNA in biospecimens from patients with thyroid tumor, as well as the potential applications of these techniques for developing microRNA-based biomarkers for the diagnosis and prognostic evaluation of thyroid cancers...
2017: International Journal of Genomics
https://www.readbyqxmd.com/read/29036818/a-9-microrna-signature-in-serum-serves-as-a-noninvasive-biomarker-in-early-diagnosis-of-alzheimer-s-disease
#6
Rui Guo, Gang Fan, Jian Zhang, Chunxiao Wu, Yifeng Du, Hui Ye, Zhang Li, Lili Wang, Zhihui Zhang, Lu Zhang, Yueran Zhao, Zhiming Lu
Alzheimer's disease (AD) is the most common type of age-related neurodegenerative disorder; nevertheless, nowadays there are no reliable biomarkers or non-invasive techniques available for its early detection. Recent studies have indicated that the circulating level profiles of microRNAs (miRNAs) have the potential to be used as valuable biomarkers for diagnosis, staging, and progress monitoring of various diseases. Here we report a novel 9-miRNA signature (hsa-miR-26a-5p, hsa-miR-181c-3p, hsa-miR-126-5p, hsa-miR-22-3p, hsa-miR-148b-5p, hsa-miR-106b-3p, hsa-miR-6119-5p, hsa-miR-1246, and hsa-miR-660-5p) that can be utilized as biomarker for detecting AD...
October 12, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29035457/evaluation-of-mir-203-expression-levels-and-dna-promoter-methylation-status-in-serum-of-patients-with-endometrial-cancer
#7
Marco Benati, Martina Montagnana, Elisa Danese, Elisa Paviati, Silvia Giudici, Massimo Franchi, Giuseppe Lippi
BACKGROUND: Endometrial cancer (EC) is currently considered the fourth most frequent female cancer in Europe. In an attempt to achieve an early diagnosis, many studies have identified some putative biomarkers for gynecologic cancers, including circulating microRNAs (miRs) and aberrant promoter methylation status. Previous studies which have investigated miR-203 expression profiles in EC tissues and normal endometrial tissues concluded that miR-203 is regulated by methylation promoter...
October 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/29035444/circulating-micrornas-expressions-as-genetic-biomarkers-in-pancreatic-cancer-patients-continuous-non-invasive-monitoring
#8
REVIEW
Mihai Sandesc, Anca Dinu, Alexandru F Rogobete, Ovidiu H Bedreag, Dorel Sandesc, Marius Papurica, Lavinia M Bratu, Silvius Negoita, Corina Vernic, Sonia E Popovici, Dan Corneci
BACKGROUND: Pancreatic cancer is one of the most important causes of death worldwide. The main cause is late detection. Also, an important factor playing a role in altering the clinical status of these patients is the lack of methods for the evaluation of therapeutic response. A marker that can be useful, both in early diagnosis and in evaluating and monitoring non-invasive treatment response, is analyzing the expression of miRNAs. In this paper, we summarize genetic and epigenetic aspects of miRNAs in pancreatic cancer...
October 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/29025589/potential-circulating-mirna-signature-for-early-detection-of-nsclc
#9
Ayda Arab, Morteza Karimipoor, Shiva Irani, Arda Kiani, Sirous Zeinali, Elham Tafsiri, Kambiz Sheikhy
Circulating microRNAs (c-miRNAs) are promising biomarkers for screening, early detection and prognosis of cancer. The purpose of this investigation was to identify a panel of c-miRNAs in plasma that could contribute to early detection of non-small cell lung cancer (NSCLC). We profiled the expression of 44 unique plasma miRNAs in training set of 34 NSCLC patients and 20 matched healthy individuals by miRCURY LNA™ Universal RT microRNA PCR Panel and calculated dysregulation fold changes using the 2-ΔΔCt equation...
October 2017: Cancer Genetics
https://www.readbyqxmd.com/read/29023315/biomarkers-of-drug-induced-kidney-injury
#10
Lynn Redahan, Patrick Murray
PURPOSE OF REVIEW: Drug-induced kidney injury (DIKI) is an important and potentially modifiable cause of acute kidney injury (AKI). The reliance on traditional markers of kidney injury to diagnose DIKI impedes early detection. Biomarkers of DIKI that facilitate early diagnosis and the identification of high-risk patients are essential to ameliorate the clinical burden of this complication. RECENT FINDINGS: Recent progress in this area supports the potential utility of several biomarkers for the diagnosis of DIKI, for the prediction of outcomes and also for monitoring responses to potential nephrotoxic or beneficial therapies...
October 11, 2017: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/29021397/varicella-zoster-virus-expresses-multiple-small-non-coding-rnas
#11
Amos Markus, Linoy Golani, Nishant Kumar Ojha, Tatiana Borodiansky-Shteinberg, Paul R Kinchington, Ronald S Goldstein
Many herpesviruses express small non coding RNAs (sncRNA), including microRNAs (miR), that may play roles in regulating lytic and latent infections. None have yet been reported in varicella zoster virus (VZV, HHV-3). Here we analyzed next generation sequencing (NGS) data for small RNAs in VZV-infected fibroblasts and human embryonic stem cell-derived (hESC) neurons. Two independent bioinformatics analyses identified more than 20 VZV-encoded 20-24 nucleotide RNAs, some of which are predicted to have stem-loop precursors potentially representing miRs...
October 11, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28990105/microrna%C3%A2-24%C3%A2-2-is-associated-with-cell-proliferation-invasion-migration-and-apoptosis-in-renal-cell-carcinoma
#12
Lu Jin, Yifan Li, Liping Nie, Tao He, Jia Hu, Jiaju Liu, Mingwei Chen, Min Shi, Zhimao Jiang, Yaoting Gui, Shangqi Yang, Yongqing Lai
Micro (mi)RNAs are involved in multiple cellular processes, and alterations in miRNA expression have been demonstrated to lead to tumorigenesis. Previous microarray analysis revealed that miRNA (miR)‑24 was downregulated in renal cell carcinoma (RCC). Additionally, miR‑24 has been identified as an oncogene and tumor suppressor in various cancers. The present study assessed the expression levels of two stem‑loops of miR‑24, miR‑24‑1 and miR‑24‑2, in RCC tissues and paired healthy tissues by reverse transcription‑quantitative polymerase chain reaction...
October 4, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28984208/unique-protein-expression-signatures-of-survival-time-in-kidney-renal-clear-cell-carcinoma-through-a-pan-cancer-screening
#13
Guangchun Han, Wei Zhao, Xiaofeng Song, Patrick Kwok-Shing Ng, Jose A Karam, Eric Jonasch, Gordon B Mills, Zhongming Zhao, Zhiyong Ding, Peilin Jia
BACKGROUND: In 2016, it is estimated that there will be 62,700 new cases of kidney cancer in the United States, and 14,240 patients will die from the disease. Because the incidence of kidney renal clear cell carcinoma (KIRC), the most common type of kidney cancer, is expected to continue to increase in the US, there is an urgent need to find effective diagnostic biomarkers for KIRC that could help earlier detection of and customized treatment strategies for the disease. Accordingly, in this study we systematically investigated KIRC's prognostic biomarkers for survival using the reverse phase protein array (RPPA) data and the high throughput sequencing data from The Cancer Genome Atlas (TCGA)...
October 3, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28977780/urinary-mirnas-as-biomarkers-for-noninvasive-evaluation-of-radiation-induced-renal-tubular-injury
#14
Sagar Bhayana, Feifei Song, Jidhin Jacob, Paolo Fadda, Nicholas C Denko, Meng Xu-Welliver, Arnab Chakravarti, Naduparambil K Jacob
Radiation nephropathy is one of the common late effects in cancer survivors who received radiotherapy as well as in victims of radiation accidents. The clinical manifestations of radiation nephropathy occur months after exposure. To date, there are no known early biomarkers to predict the future development of radiation nephropathy. This study focuses on the development of urinary biomarkers providing readout of acute responses in renal tubular epithelial cells. An amplification-free hybridization-based nCounter assay was used to detect changes in mouse urinary miRNAs after irradiation...
October 4, 2017: Radiation Research
https://www.readbyqxmd.com/read/28971890/altered-mirna-profile-dependent-on-art-outcome-in-early-pregnancy-targets-wnt-pathway
#15
Alexander Freis, Andreas Keller, Nicole Ludwig, Eckart Meese, Julia Jauckus, Julia Rehnitz, Edison Capp, Thomas Strowitzki, Ariane Germeyer
Main goal of this study is to detect possible alterations in microRNA(miRNA)-expression and the pathway targeted in plasma at the time of embryo transfer and pregnancy testing dependent on the assisted reproductive treatment (ART) outcome after ovarian hyperstimulation for in vitro fertilization. Changes in miRNA-expression in plasma of women, who became pregnant (n=6) vs. women who failed implantation (n=6) following day 5 embryo transfer (ET), were investigated at day of ET and pregnancy testing (PT). Protein expression to validate the finding was performed with a sample size of n=20 (10 per group) using enzyme-linked immunosorbent assay...
September 29, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28971758/circulating-micrornas-valuable-biomarkers-for-diagnosis-and-prognosis-of-gastric-cancer
#16
Najibeh Shekari, Behzad Baradaran, Dariush Shanehbandi, Tohid Kazemi
Gastric cancer (GC) as a global health problem is one of the deadliest cancer all over the world. Poor clinical symptoms, unfavorable prognosis and absence of proper diagnostic techniques for early detection cause GC as the third lethal cancer in the world. Presence of sensitive and specific biomarkers for early detection and monitoring the progression of GC could lead to the reduction of mortality. MicroRNAs (miRNAs) are gene regulator RNAs play important roles in tumorgenesis. In addition to intracellular miRNAs, circulating miRNAs faithfully reflect the state of cancer progression and provide a promising perspective on early diagnosis of GC...
October 3, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28966883/micrornas-in-cancer-challenges-and-opportunities-in-early-detection-disease-monitoring-and-therapeutic-agents
#17
Namita Chatterjee, Shushan Rana, Cristina Espinosa-Diez, Sudarshan Anand
PURPOSE OF REVIEW: The goals of this review are to examine the usefulness of miRNAs as diagnostic and prognostic biomarkers for cancer and to evaluate the applicability of miRNAs as cancer therapeutics. RECENT FINDINGS: Examination of miRNA milieu from body fluids offers a new alternative for quick, affordable and easy analysis of disease status in patients. Blood-based exosomal miRNAs have increased stability and are an excellent choice for clinical cancer diagnostics and prognostics...
March 2017: Current Pathobiology Reports
https://www.readbyqxmd.com/read/28964816/quinalizarin-inhibits-adipogenesis-through-down-regulation-of-transcription-factors-and-microrna-modulation
#18
Lisa Schwind, Lisa Nalbach, Andreas D Zimmer, Katja B Kostelnik, Jennifer Menegatti, Friedrich Grässer, Claudia Götz, Mathias Montenarh
BACKGROUND: Protein kinase CK2 is induced early in adipogenesis whereas later on, this kinase seems to be dispensable. Here, we have analysed how CK2 might be involved in early steps of differentiation of 3T3-L1 cells. METHODS: 3T3-L1 cells were differentiated to adipocytes in the absence or presence of quinalizarin. The expression and localization of important transcription factors was analysed by Western blot and immunofluorescence. DNA binding capacity and transactivation was analysed with pull-down assays and with luciferase reporter experiments, respectively...
September 27, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28964576/the-diagnostic-role-of-plasma-circulating-precursors-of-mirna-944-and-mirna-3662-for-non-small-cell-lung-cancer-detection
#19
Tomasz Powrózek, Barbara Kuźnar-Kamińska, Marcin Dziedzic, Radosław Mlak, Halina Batura-Gabryel, Dariusz Sagan, Paweł Krawczyk, Janusz Milanowski, Teresa Małecka-Massalska
INTRODUCTION: microRNA (miRNA) seem to be most attractive cancer markers due their crucial role in tumor development and possibility of their analysis using liquid biopsy. To date there is little known about role of miRNA precursors (pri-miRNA) in carcinogenesis and their utility as tumor markers. MATERIAL AND METHODS: miRNA-944 and miRNA-3662 precursors as potential non-small cell lung cancer (NSCLC) markers were analyzed in plasma samples of 56 patients in an early stage of NSCLC and 100 healthy individuals...
September 18, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28961259/elevated-plasma-mirna-122-140-3p-720-2861-and-3149-during-early-period-of-acute-coronary-syndrome-are-derived-from-peripheral-blood-mononuclear-cells
#20
Xiang-Dong Li, Yue-Jin Yang, Lai-Yuan Wang, Shu-Bin Qiao, Xiang-Feng Lu, Yong-Jian Wu, Bo Xu, Hong-Fan Li, Dong-Feng Gu
OBJECTIVE: Our previous study has found that circulating microRNA (miRNA, or miR) -122, -140-3p, -720, -2861, and -3149 are significantly elevated during early stage of acute coronary syndrome (ACS). This study was conducted to determine the origin of these elevated plasma miRNAs in ACS. METHODS: qRT-PCR was performed to detect the expression profiles of these 5 miRNAs in liver, spleen, lung, kidney, brain, skeletal muscles, and heart. To determine their origins, these miRNAs were detected in myocardium of acute myocardial infarction (AMI), and as well in platelets and peripheral blood mononuclear cells (PBMCs, including monocytes, circulating endothelial cells (CECs) and lymphocytes) of the AMI pigs and ACS patients...
2017: PloS One
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