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MicroRNAs and early detection

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https://www.readbyqxmd.com/read/28306671/noninvasive-monitoring-of-acute-and-chronic-rejection-in-heart-transplantation
#1
Maria G Crespo-Leiro, Gonzalo Barge-Caballero, David Couto-Mallon
PURPOSE OF REVIEW: Recent years have seen advances in the early detection of cardiac graft rejection. RECENT FINDINGS: We review the possibilities offered by tissue Doppler imaging and speckle tracking echocardiography, cardiac magnetic resonance, cardiac computed tomography, single positron emission tomography, gene expression profiling, and quantitation of donor-derived cell-free DNA, and microRNAs. SUMMARY: Noninvasive monitoring of acute and chronic rejection after cardiac transplantation is an unmet need and remains a challenge...
March 16, 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/28303893/changes-in-mirna-in-the-lung-and-whole-blood-after-whole-thorax-irradiation-in-rats
#2
Feng Gao, Pengyuan Liu, Jayashree Narayanan, Meiying Yang, Brian L Fish, Yong Liu, Mingyu Liang, Elizabeth R Jacobs, Meetha Medhora
We used a rat model of whole thorax x-ray irradiation to profile the microRNA (miRNA) in lung and blood up to 4 weeks after radiation. MiRNA from normal and irradiated Wistar rat lungs and whole blood were analyzed by next-generation sequencing and the changes by radiation were identified by differential deRNA-seq 1, 2, 3 and 4 weeks after irradiation. The average total reads/library was 2,703,137 with a mean of 88% mapping to the rat genome. Detailed profiles of 100 of the most abundant miRNA in rat blood and lung are described...
March 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28301276/epigenetic-alterations-as-biomarkers-in-pancreatic-ductal-adenocarcinoma
#3
Pascal Syren, Roland Andersson, Monika Bauden, Daniel Ansari
Pancreatic ductal adenocarcinoma (PDAC) prognosis remains very poor and has only marginally improved during the last decades. Epigenetic alterations have been the focus of many recent studies and offer valuable options for PDAC detection, prognosis and treatment. DNA methylation, histone modifications and microRNA (miR) level changes can be used as biomarkers. These alterations occur early in carcinogenesis and may be specific for PDAC. Additionally, epigenetic alterations can be analyzed from cell-free DNA, free-circulating nucleosomes or shed tumor cells in blood...
March 16, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28298901/unveiling-another-missing-piece-in-ebv-driven-lymphomagenesis-ebv-encoded-micrornas-expression-in-eber-negative-burkitt-lymphoma-cases
#4
Lucia Mundo, Maria R Ambrosio, Matteo Picciolini, Giuseppe Lo Bello, Sara Gazaneo, Leonardo Del Porro, Stefano Lazzi, Mohsen Navari, Noel Onyango, Massimo Granai, Cristiana Bellan, Giulia De Falco, Davide Gibellini, Pier P Piccaluga, Lorenzo Leoncini
Epstein-Barr virus (EBV) is a gammaherpesvirus linked to a number of lymphoid and epithelial malignancies, including Burkitt lymphoma (BL) in which its frequency ranges from 30% in sporadic cases to 100% in the endemic ones. The possible contribution of EBV to BL pathogenesis is largely unknown. It has been suggested that EBV may be associated with all of the cases, including those diagnosed as EBV negative by a mechanism of hit-and-run. Early during oncogenesis, viral genes are essential for initiating disease...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28292471/elevated-microrna-520g-in-pre-eclampsia-inhibits-migration-and-invasion-of-trophoblasts
#5
Liansheng Jiang, Anxiong Long, Longyi Tan, Mao Hong, Jingjing Wu, Leiming Cai, Qian Li
INTRODUCTION: Pre-eclampsia (PE) is a common and severe obstetric complication. MicroRNAs (miRs) have emerged as molecules that are associated with the disease. METHODS: Quantitative reverse transcription PCR (RT-qPCR) was used for serum miR-520g characterization from 19 severe pre-eclamptic and 19 normal pregnancies. In situ hybridation was adopted to localize microRNA-520g (miR-520g). Migration and invasion of HTR-8/SVneo cells were evaluated after miR-520g mimic treatment with transwell system...
March 2017: Placenta
https://www.readbyqxmd.com/read/28286035/identification-and-characterization-of-two-putative-micrornas-encoded-by-bombyx-mori-cypovirus
#6
Zhong-Hua Pan, Ping Wu, Kun Gao, Cheng-Xiang Hou, Guang-Xing Qin, Tao Geng, Xi-Jie Guo
Viral microRNAs (miRNAs) have been demonstrated to play important roles in virus-host interactions. Some RNA virus-encoded miRNAs have been reported to promote viral replication and may be used as potential drug targets. Bombyx mori cypovirus (BmCPV), an important pathogen of silkworm, is a double-stranded RNA virus frequently causing serious damages in sericulture. Research on miRNA encoded by BmCPV may be useful to elucidate the BmCPV-host interaction and to develop new anti-viral methods. In our previous study, small RNA libraries of the midgut of BmCPV-infected silkworm have been generated by deep sequencing and several BmCPV-encoded putative miRNAs were predicted...
March 8, 2017: Virus Research
https://www.readbyqxmd.com/read/28278198/blood-pressure-and-expression-of-micrornas-in-whole-blood
#7
Zhou Zhang, Brian Thomas Joyce, Jacob K Kresovich, Yinan Zheng, Jia Zhong, Ruchi Patel, Wei Zhang, Lei Liu, Chang Dou, John P McCracken, Anaité Díaz, Valeria Motta, Marco Sanchez-Guerra, Shurui Bian, Pier Alberto Bertazzi, Joel Schwartz, Andrea A Baccarelli, Sheng Wang, Lifang Hou
BACKGROUND: Blood pressure (BP) is a complex, multifactorial clinical outcome driven by genetic susceptibility, behavioral choices, and environmental factors. Many molecular mechanisms have been proposed for the pathophysiology of high BP even as its prevalence continues to grow worldwide, increasing morbidity and marking it as a major public health concern. To address this, we evaluated miRNA profiling in blood leukocytes as potential biomarkers of BP and BP-related risk factors. METHODS: The Beijing Truck Driver Air Pollution Study included 60 truck drivers and 60 office workers examined in 2008...
2017: PloS One
https://www.readbyqxmd.com/read/28272696/a-meta-analysis-of-the-relations-between-blood-microrna-208b-detection-and-acute-myocardial-infarction
#8
W-Q Zhang, B-Q Xie
OBJECTIVE: To investigate the relationship between the expression levels of microRNA-208b and early diagnosis of the acute myocardial infarction. MATERIALS AND METHODS: Literature search were performed within PubMed, Medline, Embase, and CNKI databases, according to inclusion and exclusion criteria, and other relevant literatures about included studies were searched to get more information about this study. Two staff members extracted data from the included studies for meta-analysis...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28267596/extracellular-vesicles-in-lung-cancer-from-bench-to-bedside
#9
REVIEW
Tsukasa Kadota, Yusuke Yoshioka, Yu Fujita, Kazuyoshi Kuwano, Takahiro Ochiya
Lung cancer is the leading cause of cancer-related deaths worldwide. Despite significant advances in lung cancer research and novel therapies, a better understanding of the disease is crucially needed to facilitate early detection and appropriate diagnoses and to improve treatment outcomes. Extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies, are released from all tested cell types and modulate cell-cell communication. EVs transfer a wide variety of molecules, such as proteins, messenger RNAs and microRNAs...
March 4, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28260877/repression-of-toll-like-receptor-4-by-microrna-149-3p-is-associated-with-smoking-related-copd
#10
Wen Shen, Jia Liu, Guohou Zhao, Minjuan Fan, Gao Song, Yang Zhang, Zhiying Weng, You Zhang
BACKGROUND: Smoking is the leading cause of COPD. Exploring molecular markers and understanding the pathogenic mechanisms of smoking-related COPD are helpful for early clinical diagnosis and treatment of the disease. This study aims to identify specific circulating microRNAs (miRNAs) from the blood of COPD patients with a long history of smoking. METHODS: Blood samples from four different groups were collected, and miRNA microarray was performed. Differential expression of miRNAs was verified by quantitative polymerase chain reaction...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28247764/application-of-spectral-crosstalk-correction-for-improving-multiplexed-microrna-detection-using-a-single-excitation-wavelength
#11
Yuanjian Liu, Min Wei, Ying Li, Anran Liu, Wei Wei, Yuanjian Zhang, Songqin Liu
MicroRNAs (miRNAs) play crucial roles in the regulation of cellular activities and are next-generation biomarkers for early cancer detection. Simultaneous monitoring of multiplexed miRNA is very important for enhancing the accuracy of cancer diagnostics. Traditional fluorescence methods for multicomponent analysis were usually operated under multiple excitation wavelengths, because spectral crosstalk is very detrimental to detecting accuracy for multicomponent analysis. Herein, we present a fluorescence strategy for multi-miRNAs detection in plasma under a single excitation wavelength...
March 10, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28243946/circulating-micrornas-and-extracellular-vesicles-as-potential-cancer-biomarkers-a-systematic-review
#12
REVIEW
Juntaro Matsuzaki, Takahiro Ochiya
Circulating non-coding RNAs, including microRNAs and long non-coding RNAs, and the protein components of extracellular vesicles are promising biomarkers for the non-invasive detection of cancer at an early stage. This systematic review discusses the increasing number of well-designed cancer biomarker-related studies that have been published worldwide. In many of these studies, high diagnostic accuracy, which is represented as the area under the receiver operating characteristic curve being >0.8, could be achieved using combinations of circulating microRNAs...
February 27, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28224282/micrornas-effective-elements-in-ear-related-diseases-and-hearing-loss
#13
REVIEW
Mohammad-Reza Mahmoudian-Sani, Ameneh Mehri-Ghahfarrokhi, Fereshteh Ahmadinejad, Morteza Hashemzadeh-Chaleshtori, Massoud Saidijam, Mohammad-Saeid Jami
miRNAs are important factors for post-transcriptional process that controls gene expression at mRNA level. Various biological processes, including growth and differentiation, are regulated by miRNAs. miRNAs have been demonstrated to play an essential role in development and progression of hearing loss. Nowadays, miRNAs are known as critical factors involved in different physiological, biological, and pathological processes, such as gene expression, progressive sensorineural hearing loss, age-related hearing loss, noise-induced hearing loss, cholesteatoma, schwannomas, and inner ear inflammation...
February 21, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28223918/rpph1-upregulates-cdc42-expression-and-promotes-hippocampal-neuron-dendritic-spine-formation-by-competing-with-mir-330-5p
#14
Yifei Cai, Ziling Sun, Huizhen Jia, Hongxue Luo, Xiaoyang Ye, Qi Wu, Yi Xiong, Wei Zhang, Jun Wan
Alzheimer's disease (AD) is a heterogeneous neurodegenerative disease. Recent studies employing microRNA-seq and genome-wide sequencing have identified some non-coding RNAs that are influentially involved in AD pathogenesis. Non-coding RNAs can compete with other endogenous RNAs by microRNA response elements (MREs) and manipulate biological processes, such as tumorigenesis. However, only a few non-coding RNAs have been reported in the pathogenesis of AD. In this study, we constructed the first competing endogenous RNA (ceRNA) network leveraging whole transcriptome sequencing and a previously studied microRNA-seq of APPswe/PS1ΔE9 transgenic mice...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28219319/biomarkers-in-alzheimer-s-disease-recent-update
#15
Sushil Sharma, Walter Lipincott
Alzheimer disease (AD) is an age-related neurodegenerative disorder, characterized by loss of memory and cognitive function. It is the common cause of dementia in elderly and is a global health concern as the population of people aged 85 and older, is growing alarmingly. Although pharmacotherapy for the treatment of AD has improved, lot of work remains to treat this devastating disease. AD pathology begins even before the onset of clinical symptoms. Because therapies could be more effective if implemented early in the disease progression, it is highly prudent to discover reliable biomarkers, to detect its exact pathophysiology during pre-symptomatic stage...
February 20, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28213880/detection-of-digestive-malignancies-and-post-gastrectomy-complications-via-gastrointestinal-fluid-examination
#16
REVIEW
Lei Huang, Aman Xu
To date, gastric carcinoma (GC) is one of the common and fatal digestive malignancies worldwide. The prognosis of GC is not always satisfactory because of late diagnosis. Scholars are keen on discovering novel accurate and economical biomarkers in body liquids for GC screening to detect and evaluate the lesion before the results of imaging techniques are obtained. While traditional serum assays have limited sensitivity and specificity, gastrointestinal juice may provide relevant specific biomarkers because of its close contact with the tumor...
February 17, 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/28203552/a-novel-panel-of-serum-mir-21-mir-155-mir-365-as-a-potential-diagnostic-biomarker-for-breast-cancer
#17
Ji-Guang Han, Yong-Dong Jiang, Chun-Hui Zhang, Yan-Mei Yang, Da Pang, Yan-Ni Song, Guo-Qiang Zhang
PURPOSE: Insufficient sensitivity and specificity prevent the use of most existing biomarkers for early detection of breast cancer. Recently, it was reported that serum microRNAs (miRNAs) may be potential biomarkers in many cancer diseases. In this study, we investigated whether serum levels of 5 miRNAs including miR-21, miR-125b, miR-145, miR-155, and miR-365 could discriminate breast cancer patients and healthy controls. METHODS: Serum levels of miRNAs were measured by using quantitative real-time polymerase chain reaction in 99 breast cancer patients and 21 healthy controls...
February 2017: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/28191475/the-potential-of-micrornas-as-novel-biomarkers-for-transplant-rejection
#18
REVIEW
Matthias Hamdorf, Satoru Kawakita, Matthew Everly
The control of gene expression by microRNAs (miRNAs, miR) influences many cellular functions, including cellular differentiation, cell proliferation, cell development, and functional regulation of the immune system. Recently, miRNAs have been detected in serum, plasma, and urine and circulating miR profiles have been associated with a variety of diseases. Rejection is one of the major causes of allograft failure and preventing and treating acute rejection are the central task for clinicians working with transplant patients...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28190836/specificity-of-microrna-detection-on-a-power-free-microfluidic-chip-with-laminar-flow-assisted-dendritic-amplification
#19
Kazuki Hasegawa, Rina Negishi, Mutsuyoshi Matsumoto, Masafumi Yohda, Kazuo Hosokawa, Mizuo Maeda
MicroRNAs (miRNAs) are attracting considerable attention as potential biomarkers for the early diagnosis of cancer. We have been developing a detection method for miRNAs on a microfluidic chip with external-power-free fluid pumping and enzyme-free amplification. The assay is completed within 20 min. Here, we describe the specificity of this miRNA detection method. First, the specificity against mismatched sequences was investigated. The nonspecific detection of a 2-nucleotide mismatched sequence was negligible, while that of a 1-nucleotide mismatched sequence was observed to a reasonable extent...
2017: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/28184024/oip5-a-target-of-mir-15b-5p-regulates-hepatocellular-carcinoma-growth-and-metastasis-through-the-akt-mtorc1-and-%C3%AE-catenin-signaling-pathways
#20
Hua Li, Jun Zhang, Mi-Jin Lee, Goung-Ran Yu, Xueji Han, Dae-Ghon Kim
Opa interacting protein 5 (OIP5) is upregulated in some types of human cancers, but the biological implications of its upregulation have not yet been clarified in human hepatocellular carcinoma (HCC). In this study, the signaling pathway downstream of OIP5 was analyzed by proteome kinase profiling. A putative microRNA targeting OIP5 was identified using a miRNA PCR array. Tumorigenicity and metastatic ability were examined in an orthotopic animal model. OIP5 expression was strongly detected in early and advanced tumors via gene expression profiling and immunohistochemical staining analyses...
February 8, 2017: Oncotarget
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