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MicroRNAs and early detection

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https://www.readbyqxmd.com/read/29227984/microrna-146b-5p-identified-in-porcine-liver-donation-model-is-associated-with-early-allograft-dysfunction-in-human-liver-transplantation
#1
Cheukfai Li, Qiang Zhao, Wei Zhang, Maogen Chen, Weiqiang Ju, Linwei Wu, Ming Han, Yi Ma, Xiaofeng Zhu, Dongping Wang, Zhiyong Guo, Xiaoshun He
BACKGROUND Poor transplant outcome was observed in donation after brain death followed by circulatory death (DBCD), since the donor organs suffered both cytokine storm of brain death and warm ischemia injury. MicroRNAs (miRNAs) have emerged as promising disease biomarkers, so we sought to establish a miRNA signature of porcine DBCD and verify the findings in human liver transplantation. MATERIAL AND METHODS MiRNA expression was determined with miRNA sequencing in 3 types of the porcine model of organ donation, including donation after brain death (DBD) group, donation after circulatory death (DCD) group, and DBCD group...
December 11, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29226953/micrornas-in-cutaneous-melanoma-role-as-diagnostic-and-prognostic-biomarkers
#2
REVIEW
Casey L Ross, Shivani Kaushik, Rodrigo Valdes-Rodriguez, Rina Anvekar
Melanoma is the leading cause of skin cancer deaths in the United States, and its incidence has been rising steadily for the past 30 years (Aftab et al, 2014). A more complete understanding of the molecular mechanisms that drive melanomagenesis is crucial to improve diagnosis, prognostication, and treatment of this disease. Given that melanoma survival rates are better when the disease is detected early, precise diagnostic tests for early melanoma detection would be extremely useful. In addition, as survival rates decrease drastically when the disease becomes metastatic, improved tools to more precisely identify high-risk patients as well as to predict treatment response are necessary...
December 11, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29226653/a-preliminary-study-of-the-value-of-plasma-microrna-193b-and-soluble-urokinase-type-plasminogen-activator-receptor-in-identifying-patients-with-early-stage-colorectal-cancer-and
#3
K L Liu, J L Luo, J Wu, Y D Wang, H J Fan
BACKGROUND: Early detection and management of colorectal cancer (CRC) and colorectal adenoma (CRA) reduces the mortality and morbidity of CRC, but there is a lack of ideal circulation biomarkers. METHODS: A total of 80 patients with early-stage CRC and CRA and 30 healthy controls were included in this preliminary study. Plasma samples were collected before colonoscopy and prepared for measurement of microRNA193b and soluble uPAR. RESULTS: Plasma level of miR-193b was decreased through the normal-adenoma-carcinoma sequence with no significant difference between patients with CRC and advanced CRA...
November 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/29226639/early-diagnosis-of-oral-squamous-cell-carcinoma-by-salivary-micrornas
#4
REVIEW
Raluca Dumache
BACKGROUND: Oral squamous cell carcinoma (OSCC), the most common type of oral cancer, and represents more than 90% of malignancies of the oral cavity. Worldwide, each year about 275,000 are newly diagnosed. If detected at an early stage, OSCC has a survival rate of up to 80% compared to the detection in later stages (T3-T4) when a survival rate of 20 - 30% is present. METHODS: Because OSCC presents these survival rates, there is an urgent need to introduce new non-invasive molecular biomarkers for the early detection of OSCC from saliva, which will contribute to an increased long term survival rate for these patients...
November 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/29224950/mrna-microrna-and-lncrna-as-novel-bladder-tumor-markers
#5
REVIEW
Edyta Wieczorek, Edyta Reszka
Early detection of bladder cancer (BC) is essential for improvement of the patient's prognosis and general survival rates. Current diagnostic methods are still limited, so new specific and cost-effective biomarkers are emerging as the noninvasive tools in treatment decisions in recurrent BC. Gene expression and epigenetic profile can be analysed using quantitative real-time-PCR (qRT-PCR) method in urine, blood and tissue. This review provides an update of recent findings on BC molecular profile as novel markers in diagnosis and prognosis of bladder tumors...
December 7, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29224731/highly-specific-real-time-quantification-of-diverse-micrornas-in-human-samples-using-universal-primer-set-frame
#6
Wancun Zhang, Jiaqi Zhang, Qi Zhang, Fang Hu, Yueqing Gu
In this study, one group of universal primer set frame, composed by one reverse transcription (RT) primer frame and a pair of quantitative real-time polymerase chain reaction (qRT-PCR) primer frames, was elaborately screened and designed by homebuilt software for sensitive and specific quantification of diverse miRNAs. The universal primer set frame can be applied for multiplex miRNAs detection by simply changing the RT-X part of RT primer frame and RP-Y part of qRT-PCR reverse primer frame based on target sequence...
December 7, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/29218272/blood-based-biomarkers-in-lung-cancer-prognosis-and-treatment-decisions
#7
REVIEW
Meng Xu-Welliver, David P Carbone
Despite recent advances, non-small cell lung cancer (NSCLC) remains a devastating disease with overall poor prognosis. Major contributing factors include obstacles to diagnosing the disease early in its course during the asymptomatic stage as well as diversity and complexity of its biology underlying tumorigenesis and tumor progression. Advances in molecularly targeted therapies which drives the development of personalized cancer care require precise and comprehensive understanding of tumor biology, not only at the time of diagnosis but also during treatment course and surveillance...
December 2017: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/29218111/the-diagnostic-value-of-microrna-4787-5p-and-microrna-4306-in-patients-with-acute-aortic-dissection
#8
Lei Wang, Shijie Zhang, Zhigao Xu, Jingjing Zhang, Li Li, Guoqiang Zhao
Acute aortic dissection (AAD) is a life-threatening cardiovascular disease with the high morbidity and mortality. Imaging modalities are the gold standard for the diagnosis of AAD; however, they are not always available in emergency department. Biomarker-assisted diagnosis is important for the early treatment of AAD. The aim of the present study was to identify potential microRNA (miRNA) biomarkers for AAD. Differentially expressed plasma miRNAs between AAD patients and age-matched healthy volunteers were analyzed by miRNA microarray...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29215707/the-diagnostic-and-prognostic-value-of-circulating-micrornas-in-coronary-artery-disease-a-novel-approach-to-disease-diagnosis-of-stable-cad-and-acute-coronary-syndrome
#9
REVIEW
Seyed Mostafa Parizadeh, Gordon A Ferns, Maryam Ghandehari, Seyed Mahdi Hasanian, Majid Ghayour-Mobarhan, Seyed Mohammad Reza Parizadeh, Amir Avan
Coronary artery disease (CAD) is the most common manifestation of CVD and the acute coronary syndrome (ACS) is associated with a substantial morbidity and mortality in most populations globally. There are several biomarkers for diagnosis of MI. Troponin is routinely used as a biomarker in patients with chest pain, but it lacks sensitivity in the first hours of onset of symptoms, and so there is still a clinical need for new biomarkers for the diagnosis of CAD events. Recent studies have shown that miRNAs are involved in atherosclerotic plaque formation and their expression is altered during CAD events...
December 7, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29207159/downregulation-of-mir%C3%A2-146a-promotes-proliferation-and-migration-of-aob%C3%A2-treated-embryoid-body-via-pdgfra-induction
#10
Lejing Li, Shoulian Zhu, Ying Li, Wenyuan Cao, Xiaoli Qiao
Antioxidant of bamboo leaves (AOB) has been proven to have antioxidant activity and an inhibitory effect on free radicals that induce deterioration of macromolecules. The multi‑target regulation of microRNAs (miRs) in the complicated process of vasculogenesis and angiogenesis lead to the use of miRNA therapy in vascular development. In the present study, the role of miRNAs on early embryo vascular development upon AOB stimulation was investigated. For this purpose, mouse embryonic stem cells were spontaneously differentiated as embryoid bodies (EBs) and were examined by phase contrast microscopy...
November 22, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29205600/circulating-microrna-signature-of-steroid-induced-osteonecrosis-of-the-femoral-head
#11
Zheng Li, Chao Jiang, Xingye Li, William K K Wu, Xi Chen, Shibai Zhu, Chanhua Ye, Matthew T V Chan, Wenwei Qian
OBJECTIVES: Steroid-induced osteonecrosis of the femoral head (ONFH) is a common orthopaedic disease of which early detection remains clinically challenging. Accumulating evidences indicated that circulating microRNAs (miRNAs) plays vital roles in the development of several bone diseases. However, the association between circulating miRNAs and steroid-induced ONFH remains elusive. MATERIALS AND METHODS: miRNA microarray was performed to identify the differentially abundant miRNAs in the serums of systemic lupus erythematosus (SLE) patients with steroid-induced ONFH as compared with SLE control and healthy control group...
December 4, 2017: Cell Proliferation
https://www.readbyqxmd.com/read/29202614/liquid-biopsies-in-gastrointestinal-malignancies-when-is-the-big-day
#12
Anthony Lopez, Kazuto Harada, Dilsa Mizrak Kaya, Xiaochuan Dong, Shumei Song, Jaffer A Ajani
Tumor tissue sample is currently the gold standard for diagnosing gastrointestinal cancers, but also for genomic/immune component analyses that can help in the selection of therapy. However, this approach of studying a 'representative' sample of the tumor does not address inherent heterogeneity. Liquid biopsies, mainly represented by circulating tumor cells, circulating tumor DNA, tumor exosomes, and microRNAs, have the potential to assess various biomarkers for early detection of cancer, carrying out genomic/immune profiling for not only selection of appropriate therapy but also to monitor effect of therapy...
December 4, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/29200660/measuring-ultra-low-levels-of-nucleotide-biomarkers-using-quartz-crystal-microbalance-and-spr-microarray-imaging-methods-a-comparative-analysis
#13
Gayan Premaratne, Zainab H Al Mubarak, Lakmini Senavirathna, Lin Liu, Sadagopan Krishnan
Circulating serum nucleotide biomarkers are useful indicators for early diagnosis of cancer, respiratory illnesses, and other deadly diseases. In this work, we compared detection performances of a quartz crystal microbalance (QCM), which is a mass sensor, with that of a surface plasmon resonance (SPR) microarray for an oligonucleotide mimic of a microRNA-21 biomarker. A surface immobilized capture oligonucleotide probe was used to hybridize with the target oligonucleotide (i.e., the microRNA-21 mimic) to facilitate selective detection...
December 2017: Sensors and Actuators. B, Chemical
https://www.readbyqxmd.com/read/29199014/microrna-regulation-of-k-ras-in-pancreatic-cancer-and-opportunities-for-therapeutic-intervention
#14
REVIEW
Saswati Karmakar, Garima Kaushik, Ramakrishna Nimmakayala, Satyanarayana Rachagani, Moorthy P Ponnusamy, Surinder K Batra
The Ras family of GTPases is involved in cell proliferation, cell survival, and angiogenesis. It is upregulated in several cancers, including pancreatic cancer (PC) and leads to uncontrolled growth and aggressiveness. PC is well known to be a lethal disease with poor prognosis, plagued by limited therapeutic modalities. MicroRNAs (miRNAs), which are short non-coding RNA molecules, have recently emerged as regulators of signaling networks and have shown potential to target pathway components for therapeutic use in several malignancies...
November 30, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/29198131/early-detection-of-cardiac-surgery%C3%A2-associated-acute-kidney-injury-by-microrna-21
#15
P Arvin, H R Samimagham, H Montazerghaem, M Khayatian, H Mahboobi, F Ghadiri Soufi
We tested the hypothesis whether microRNA-21 (miR-21) can detect CSA-AKI earlier than serum creatinine (sCr). A total of 103 patients scheduled to undergo cardiac surgery. CSA-AKI was defined as sCr > 0.3 mg/dl 24 h after surgery. The patients were divided into two groups according to whether or not developing AKI after surgery. Serum and urinary miR-21 were measured prior to, and 6, 12 and 24 h after surgery. Baseline serum and urinary levels of miR-21 in AKI group were lower than in non-AKI group. Moreover, the levels of miR-21 were significantly lower 6 h after surgery for serum, and 6 and 12 h after surgery for urine samples than those before surgery in AKI group...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29177063/circulating-micrornas-as-potential-biomarkers-to-detect-transformation-of-barrett-s-oesophagus-to-oesophageal-adenocarcinoma
#16
Juntaro Matsuzaki, Hidekazu Suzuki
Objective: Circulating microRNAs (miRNAs) are promising biomarkers for the early detection of cancers. This study aimed to address potential circulating miRNAs to monitor the progression from Barrett's oesophagus (BO) to oesophageal adenocarcinoma (OAC). Design: We comprehensively analysed tissue and serum miRNA expression profiles of BO mice model (L2-interleukin-1β (IL-1β) mice) using microarray analysis. To validate the data from mice, a published dataset of human plasma miRNAs, consisting of eight patients with OAC, eight with BO and six healthy controls, was used (GSE51410)...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29175307/extracellular-vesicles-in-obesity-and-diabetes-mellitus
#17
REVIEW
Fabián Pardo, Roberto Villalobos-Labra, Bastián Sobrevia, Fernando Toledo, Luis Sobrevia
Cell-to-cell communication happens via diverse mechanisms including the synthesis, release and transfer to target cells of extracellular vesicles (EVs). EVs include nanovesicles (i.e., exosomes) and microvesicles, including apoptotic bodies. The amount and cargo of released EVs, which consist of microRNAs (miRNAs), mRNA, proteins, DNA, among other molecules, are altered in obesity and diabetes mellitus. EVs from these diseases show with altered cargo including several miRNAs and the enrichment with molecules involved in inflammation, immune efficiency, and cell activation...
November 24, 2017: Molecular Aspects of Medicine
https://www.readbyqxmd.com/read/29166878/the-andromeda-prospective-cohort-study-predictive-value-of-combined-criteria-to-tailor-breast-cancer-screening-and-new-opportunities-from-circulating-markers-study-protocol
#18
Livia Giordano, Federica Gallo, Elisabetta Petracci, Giovanna Chiorino, Nereo Segnan
BACKGROUND: In recent years growing interest has been posed on alternative ways to screen women for breast cancer involving different imaging techniques or adjusting screening interval by breast cancer risk estimates. A new research area is studying circulating microRNAs as molecular biomarkers potentially useful for non invasive early detection together with the analysis of single-nucleotide polymorphisms (SNPs). The Andromeda study is a prospective cohort study on women attending breast cancer screening in a northern Italian area...
November 22, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29163821/the-clinical-use-of-circulating-micrornas-as-non-invasive-diagnostic-biomarkers-for-lung-cancers
#19
Yanlong Yang, Zaoxiu Hu, Yongchun Zhou, Guangqiang Zhao, Yujie Lei, Guangjian Li, Shuai Chen, Kai Chen, Zhenghai Shen, Xiao Chen, Peilin Dai, Yunchao Huang
Many studies have investigated the diagnostic role of circulating microRNAs (miRNAs) in patients with lung cancer; however, the results still remain inconclusive. An updated system review and meta-analysis was necessary to give a comprehensive evaluation of diagnostic role of circulating miRNAs in lung cancer. Eligible studies were searched in electronical databases. The sensitivity and specificity were used to plot the summary receiver operator characteristic (SROC) curve and calculate the area under the curve (AUC)...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29163790/a-combination-of-circulating-mirnas-for-the-early-detection-of-ovarian-cancer
#20
Akira Yokoi, Yusuke Yoshioka, Akihiro Hirakawa, Yusuke Yamamoto, Mitsuya Ishikawa, Shun-Ichi Ikeda, Tomoyasu Kato, Kaoru Niimi, Hiroaki Kajiyama, Fumitaka Kikkawa, Takahiro Ochiya
Ovarian cancer is the leading cause of gynecologic cancer mortality, due to the difficulty of early detection. Current screening methods lack sufficient accuracy, and it is still challenging to propose a new early detection method that improves patient outcomes with less-invasiveness. Although many studies have suggested the utility of circulating microRNAs in cancer detection, their potential for early detection remains elusive. Here, we develop novel predictive models using a combination of 8 circulating serum miRNAs...
October 27, 2017: Oncotarget
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