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https://www.readbyqxmd.com/read/28549942/tissue-specific-expression-profile-of-some-immune-related-genes-in-labeo-rohita-to-edwardsiella-tarda-infection
#1
Sajal Kole, Deepika Anand, Rupam Sharma, Gayatri Tripathi, Makesh M, Rajendran Kv, Megha Kadam Bedekar
Rohu (Labeo rohita), an Indian Major Carp (IMC) is an economically important aquaculture species in India. Inspite of the technological advances, infectious diseases caused by viruses, bacteria and parasites have been a major limiting factor in the development and profitability of fish farms. At present, information regarding the immune status of the Indian major carps is limited. This lack of knowledge is a major impediment for establishment of effective preventive measures against broad spectrum of infectious agents...
May 23, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28544099/genetic-signatures-coupled-with-lineage-shift-characterize-endemic-evolution-of-dengue-virus-serotype-2-during-2015-outbreak-in-delhi-india
#2
Manish Chandra Choudhary, Ekta Gupta, Shvetank Sharma, Nadeem Hasnain, Pragya Agarwala
OBJECTIVE: In 2015 New Delhi witnessed a massive outbreak of Dengue virus (DENV) resulting in high morbidity and mortality. We report the molecular characterization of the dominant circulating DENV strain to understand its evolution and dispersal. MATERIALS AND METHODS: DENV infections were diagnosed by detection of IgM/NS1 antigen and serotyping was performed by C-PrM PCR. Envelope gene was amplified and variation(s) in envelope gene were analyzed. Phylogenetic tree construction, time-based phylogeny and origin of DENV were analyzed...
May 23, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28543433/mumps-outbreak-in-a-tribal-population-from-the-union-territory-of-dadra-and-nagar-haveli-india
#3
Siddharth M Tilavat, Sunil R Vaidya, Venkat S Hamde
A cluster of parotitis cases (n=13) were observed in a tribal population of Vansda village from the Union Territory of Dadra and Nagar Haveli, India between 20(th) and 22(nd) week of 2016. Primary information was received by the local Infectious Disease Surveillance Program team, and subsequently field investigations were carried out in the affected area. Active surveillance was conducted till twice the incubation period from onset of the last surveyed case. For the laboratory investigations, 19 serum samples were collected from 11-suspected cases and their close contacts (n=8)...
May 20, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28542279/oligopeptides-as-full-length-new-delhi-metallo-%C3%AE-lactamase-1-ndm-1-inhibitors
#4
Bingzheng Shen, Chengliang Zhu, Xiang Gao, Gang Liu, Jinchun Song, Yan Yu
'Superbug' bacteria producing NDM-1 enzyme causing wide public concern were first detected in a patient who visited India in 2008. It's an effective approach to combining β-lactam antibiotics with NDM-1 inhibitor for treating NDM-1 producing strain infection. In our research, we designed ten oligopeptides, tested IC50 values against NDM-1 enzyme, determined the MIC values of synergistic antibacterial effect and explored the binding model. We found that the oligopeptides 2 (Cys-Phe) and 5 (Cys-Asp) respectively presented IC50 values of 113 μM and 68 μM and also displayed favorable synergistic effects of the inhibitors in combination with ertapenem against genetic engineering-host E...
2017: PloS One
https://www.readbyqxmd.com/read/28540891/chronic-renal-failure-an-autopsy-study
#5
Anitha Padmanabhan, Sanjay Gohil, N M Gadgil, Prerna Sachdeva
Diabetes and hypertension are at present the major causes of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide. The stages 0-5 of CKD are defined according to the estimated glomerular filtration rate. The term chronic renal failure (CRF) typically corresponds to CKD stages 3-5. Cardiovascular disease is the main cause of morbidity and mortality in patients of CRF and ESRD. This study was undertaken to analyze the age and sex incidence, clinical features, etiology, pathology of various organs in detail, and causes of death of CRF patients...
May 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28539863/pulmonary-aspergillosis-as-opportunistic-mycoses-in-a-cohort-of-human-immunodeficiency-virus-infected-patients-report-from-a-tertiary-care-hospital-in-north-india
#6
Ravinder Kaur, Bhanu Mehra, Megh Singh Dhakad, Ritu Goyal, Richa Dewan
OBJECTIVE: The incidence of pulmonary aspergillosis in human immunodeficiency virus (HIV)-infected persons is rising. This study was designed to determine the prevalence of pulmonary aspergillosis in a cohort of HIV-positive patients (n = 71) presenting with lower respiratory tract infection at a tertiary care medical center in India. METHODS: Sputum samples were collected, and potassium hydroxide mount, cultural characteristics, and lactophenol cotton blue preparations were employed to aid in the identification of Aspergillus species...
April 2017: International Journal of Health Sciences
https://www.readbyqxmd.com/read/28529359/the-journey-of-opioid-substitution-therapy-in-india-achievements-and-challenges
#7
Ravindra Rao
Opioids are one of the most problematic illegal substances globally. Opioid abuse is associated with complications in various spheres of the user's life, his/her family, and the society. Injecting drug use (IDU) is also linked to public health problems such as HIV infection and viral hepatitis. Medications form an important cornerstone in the treatment of opioid dependence. Treatment strategies such as "detoxification" alone or long-term treatment with opioid antagonist have limited acceptability and retention rates...
January 2017: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/28529014/comparative-prospective-study-between-medial-and-lateral-distal-tibial-locking-compression-plates-for-distal-third-tibial-fractures
#8
Sandeep Garg, Vikram Khanna, Mahaveer Prashad Goyal, Narendra Joshi, Amrut Borade, Ishan Ghuse
PURPOSE: Tibial fracture is the most common long bone fracture. Distal third tibial fractures are challenging though open reduction and plating can result in anatomical reduction and rigid fixation. This paper aimed to evaluate and compare the results of medial and lateral locking compression plates for distal third tibial fractures. METHODS: This prospective clinical study involved 36 patients with distal tibial fractures admitted in Department of Orthopaedics, Sawai Mansingh Medical College & Affiliated Hospital, Jaipur, India, from June 2011 to May 2012, including 29 closed fractures and 7 open fractures at the mean age of 38...
April 14, 2017: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/28527158/asymptomatic-cryptococcal-antigenemia-in-people-living-with-hiv-plhiv-with-severe-immunosuppression-is-routine-crag-screening-indicated-in-india
#9
S Anuradha, Abhaya Narayana H, Richa Dewan, Ravinder Kaur, K Rajeshwari
BACKGROUND: Cryptococcal meningitis (CM) is a common, life-threatening opportunistic infection (OI) among people living with HIV (PLHIV) in India. Serum Cryptococcal antigen (CrAg) positivity is predictive of future occurrence of CM and pre-emptive treatment reduces its mortality. Routine CrAg screening among PLHIV is not adopted by India's national programme. This study evaluated the prevalence of CrAg and assessed CrAg positivity in predicting all-cause mortality among PLHIV. METHODS: This prospective study was conducted in a tertiary care, public health facility in New Delhi, India...
April 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28527099/molecular-diversity-among-viroids-infecting-chrysanthemum-in-india
#10
C R Adkar-Purushothama, G Chennappa, K Poornachandra Rao, M Y Sreenivasa, P K Maheshwar, M N Nagendra Prasad, T Sano
Association of Chrysanthemum stunt viroid (CSVd) and Chrysanthemum chlorotic mottle viroid (CChMVd) with the Chrysanthemum plants exhibiting severe stunting, distinct yellow leaf mottling, and chlorosis was detected in the main chrysanthemum-growing regions of India. Sequence analysis of 90 cDNA clones obtained for CSVd and CChMVd, representing the chrysanthemum-growing regions of India, revealed the high degree of sequence variation throughout the genome under natural conditions. Additionally, all the analyzed CChMVd clones revealed the presence of UUUC in the tetraloop, a signature of symptomatic variants in susceptible cultivars...
May 19, 2017: Virus Genes
https://www.readbyqxmd.com/read/28525619/epidemiology-and-clinical-characteristics-of-invasive-mould-infections-a-multicenter-retrospective-analysis-in-five-asian-countries
#11
R Porpon, Y C Chen, A Chakrabarti, R Y Li, R M Shivaprakash, J Yu, H C Kung, S Watcharananan, A L Tan, S E Saffari, B H Tan
Formal, large-scale, multicenter studies of invasive mould infection (IMI) in Asia are rare. This 1-year, retrospective study was designed to assess the incidence and clinical determinants of IMI in centers in five countries (Thailand, Taiwan, Singapore, China, India). Patients treated in a single year (2012) were identified through discharge diagnoses, microbiology, and histopathology logs, and entered based on published definitions of IMI. A total of 155 cases were included (median age 54 years; 47.7% male)...
May 19, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28525618/establishing-expanding-and-certifying-a-closed-colony-of-phlebotomus-argentipes-diptera-psychodidae-for-xenodiagnostic-studies-at-the-kala-azar-medical-research-center-muzaffarpur-bihar-india
#12
Puja Tiwary, Shakti Kumar Singh, Anurag Kumar Kushwaha, Edgar Rowton, David Sacks, Om Prakash Singh, Shyam Sundar, Phillip Lawyer
This pilot project was preliminary and essential to a larger effort to define the ability of certain human-subject groups across the infection spectrum to serve as reservoirs of Leishmania donovani infection to sand flies in areas of anthroponotic transmission such as in Bihar state, India. This is possible only via xenodiagnosis of well-defined subject groups using live vector sand flies. The objective was to establish at the Kala Azar Medical Research Center (KAMRC), Muzaffarpur, Bihar, India, a self-sustaining colony of Phlebotomus argentipes (Annandale & Brunneti), closed to infusion with wild-caught material and certified safe for human xenodiagnosis...
May 19, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/28521786/role-of-routine-abdominal-ultrasonography-in-intensified-tuberculosis-case-finding-algorithms-at-hiv-clinics-in-high-tb-burden-settings
#13
Sonam Spalgais, Upasna Agarwal, Rohit Sarin, Devesh Chauhan, Anita Yadav, Anand Jaiswal
BACKGROUND: High proportion of TB in people living with HIV (PLHIV) is undiagnosed. Due to this active TB case finding is recommended for HIV clinics in high TB burden countries. Presently sputum examination and chest radiography are frontline tests recommended for HIV infected TB presumptives. Abdominal TB which occurs frequently in PLHIV may be missed even by existing programmatic intensified case finding protocols. This study evaluated the routine use of ultrasonography (USG) for active case finding of abdominal TB in HIV clinics...
May 18, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28520728/cost-effectiveness-of-hepatitis-c-treatment-using-generic-direct-acting-antivirals-available-in-india
#14
Rakesh Aggarwal, Qiushi Chen, Amit Goel, Nicole Seguy, Razia Pendse, Turgay Ayer, Jagpreet Chhatwal
BACKGROUND & AIMS: Availability of directly-acting antivirals (DAAs) has changed the treatment landscape of hepatitis C virus (HCV) infection. The high price of DAAs has restricted their use in several countries. However, in some countries such as India, generic DAAs are available at much cheaper price. This study examined whether generic DAAs could be cost-saving and how long it would take for the treatment to become cost-saving/effective. METHODS: A previously-validated, mathematical model was adapted to the HCV-infected population in India to compare the outcomes of no treatment versus treatment with DAAs...
2017: PloS One
https://www.readbyqxmd.com/read/28513837/maternal-near-miss-in-low-resource-areas
#15
Robert L Goldenberg, Sarah Saleem, Sumera Ali, Janet L Moore, Adrien Lokangako, Antoinette Tshefu, Musaku Mwenechanya, Elwyn Chomba, Ana Garces, Lester Figueroa, Shivaprasad Goudar, Bhalachandra Kodkany, Archana Patel, Fabian Esamai, Paul Nsyonge, Margo S Harrison, Melissa Bauserman, Carl L Bose, Nancy F Krebs, K Michael Hambidge, Richard J Derman, Patricia L Hibberd, Edward A Liechty, Dennis D Wallace, Jose M Belizan, Menachem Miodovnik, Marion Koso-Thomas, Waldemar A Carlo, Alan H Jobe, Elizabeth M McClure
OBJECTIVE: To describe the Global Network Near-Miss Maternal Mortality System and its application in seven sites. METHODS: In a population-based study, pregnant women eligible for enrollment in the Maternal and Newborn Health Registry at seven sites (Democratic Republic of the Congo; Guatemala; Belagavi and Nagpur, India; Kenya; Pakistan; and Zambia) between January 2014 and April 2016 were screened to identify those likely to have a near-miss event. The WHO maternal near-miss criteria were modified for low-resource settings...
May 17, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28512381/first-report-and-comparative-study-of-steinernema-surkhetense-rhabditida-steinernematidae-and-its-symbiont-bacteria-from-subcontinental-india
#16
Aashiq Hussain Bhat, Istkhar, Ashok Kumar Chaubey, Vladimir Půža, Ernesto San-Blas
Two populations (CS19 and CS20) of entomopathogenic nematodes were isolated from the soils of vegetable fields from Bijnor district, India. Based on morphological, morphometrical, and molecular studies, the nematodes were identified as Steinernema surkhetense. This work represents the first report of this species in India. The infective juveniles (IJs) showed morphometrical and morphological differences, with the original description based on longer IJs size. The IJs of the Indian isolates possess six ridges in their lateral field instead of eight reported in the original description...
March 2017: Journal of Nematology
https://www.readbyqxmd.com/read/28511414/a-community-based-study-on-pelvic-inflammatory-disease-in-postmenopausal-females-microbiological-spectrum-and-socio-demographic-correlates
#17
Samreen Khan, M Athar Ansari, Shaista M Vasenwala, Zehra Mohsin
INTRODUCTION: Pelvic Inflammatory Disease (PID) is a common and serious complication of sexually transmitted diseases in young women but is rarely diagnosed in the postmenopausal women. Very few studies have been done regarding post-menopausal PID. AIM: To determine the burden of PID, associated micro-organisms, pathophysiology and risk factors among post-menopausal women of the community. MATERIALS AND METHODS: A cross-sectional study was conducted among 530 post-menopausal women in the registered field practice areas of the JN Medical College and Hospital, Aligarh, Uttar Pradesh, India...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28511383/study-on-mics-of-tigecycline-in-clinical-isolates-of-carbapenem-resistant-enterobacteriaceae-cre-at-a-tertiary-care-centre-in-north-india
#18
Vineeta Khare, Prashant Gupta, Fareya Haider, Rehana Begum
INTRODUCTION: Members of family Enterobacteriaceae are the most common Gram-negative bacteria isolated from clinical samples. Those Enterobacteriaceae which have acquired resistance to all β-lactams antibiotics including the carbapenems are considered as Carbapenem Resistant Enterobacteriaceae (CRE). These CRE isolates are often resistant to most other classes of antimicrobials as well, making their treatment a great challenge. Tigecycline is one of the last resort antimicrobials against such multidrug resistant bacteria...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28511380/fungal-profile-of-vulvovaginal-candidiasis-in-a-tertiary-care-hospital
#19
Krishnapriya Kalaiarasan, Rakesh Singh, Latha Chaturvedula
INTRODUCTION: Vulvovaginal Candidiasis (VVC) is a common medical health problem of adult women. It is most commonly caused by Candida albicans. But there is a change in fungal profile. Sabouraud's Dextrose Agar (SDA) is the most common culture medium used where mixed fungal infection may be missed. It can be detected easily by using chromogenic culture medium. AIM: To know the fungal profile of vulvovaginal candidiasis using Candida CHROMagar and antifungal susceptibility pattern in patients attending tertiary care hospital...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28510994/improved-detection-of-burkholderia-pseudomallei-from-non-blood-clinical-specimens-using-enrichment-culture-and-pcr-narrowing-diagnostic-gap-in-resource-constrained-settings
#20
Chaitanya Tellapragada, Tushar Shaw, Annet D'Souza, Vandana Kalwaje Eshwara, Chiranjay Mukhopadhyay
OBJECTIVES: To evaluate the diagnostic utility of enrichment culture and PCR for improved case detection rates of non-bacteremic form of melioidosis in limited resource settings. METHODS: Clinical specimens (n=525) obtained from patients presenting at a tertiary care hospital of south India with clinical symptoms suggestive of community-acquired pneumonia, lower respiratory tract infections, superficial or internal abscesses, chronic skin ulcers and bone or joint infections were tested for the presence of Burkholderia pseudomallei using conventional culture (CC), enrichment culture (EC) and PCR...
May 16, 2017: Tropical Medicine & International Health: TM & IH
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