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subarachnoid hemorrhage and vasospasm

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https://www.readbyqxmd.com/read/29456646/an-experimental-rabbit-model-of-symptomatic-cerebral-vasospasm-with-in-vivo-neuroimaging-assessment-and-ex-vivo-histological-validation
#1
Yunchang Mo, Luping Huang, Linbi Chen, Michael Veronesi, Yiyi Shi, Sijia Chen, Linli Peng, Leping Zhou, Yonglin Pu, Junlu Wang
Cerebral vasospasm (CVS) is a severe complication that occurs following aneurysmal subarachnoid hemorrhage (SAH). Magnetic resonance angiography (MRA) has been used to evaluate brain injury following SAH in humans. The present study was designed to assess a rabbit model of symptomatic CVS (SCVS) and the utility of MRA in evaluating SCVS in rabbits. Japanese white rabbits (n=24) were randomly divided into 2 equal groups: A sham group and a SAH group. Neurological scores were evaluated for 7 days following SAH...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29455413/influence-of-abo-blood-type-on-the-outcome-after-non-aneurysmal-subarachnoid-hemorrhage
#2
Daniel Dubinski, Sae-Yeon Won, Bedjan Behmanesh, Sepide Kashefiolasl, Christof Geisen, Volker Seifert, Christian Senft, Juergen Konczalla
BACKGROUND: In patients with non-aneurysmal subarachnoid hemorrhage (NA-SAH), the etiology is unknown and the bleeding source remains unidentified. However, the ABO blood type system has a profound role in patient's hemostasis and thrombosis. To date, the aspect of ABO blood type in incidence, clinical course, and outcome after NA-SAH has not been investigated. METHODS: In this retrospective analysis, 81 patients with non-traumatic and non-aneurysmal subarachnoid hemorrhage treated between 2010 and 2014 at the author's institution were included...
February 17, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29434735/expression-of-mmp-9-and-il-6-in-patients-with-subarachnoid-hemorrhage-and-the-clinical-significance
#3
Luchen Wang, Ziyun Gao
The purpose of the present study was to investigate the expression of matrix metalloproteinase-9 (MMP-9) and interleukin-6 (IL-6) in patients with subarachnoid hemorrhage (SAH) and the clinical significance thereof. Forty-three patients with SAH and 23 healthy individuals were enrolled in this study. Patients were divided into the cerebral vasospasm (CVS) and non-cerebral vasospasm (non-CVS) groups, or the good and poor prognosis groups. Serum levels of MMP-9 and IL-6 were detected by ELISA. Expression levels of MMP-9 and IL-6 mRNAs were detected by RT-qPCR...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29425980/dose-dependent-effects-of-statins-for-patients-with-aneurysmal-subarachnoid-hemorrhage-meta-regression-analysis
#4
REVIEW
Minh-Son To, Shivesh Prakash, Santosh I Poonnoose, Shailesh Bihari
OBJECTIVE: The study utilizes meta-regression analysis to quantify the dose-dependent effects of statin pharmacotherapy on vasospasm, delayed ischemic neurologic deficits (DINDs) and mortality in aneurysmal subarachnoid hemorrhage (aSAH). METHODS: Prospective, retrospective observational studies and randomized controlled trials (RCTs) were retrieved by a systematic database search. Summary estimates were expressed as absolute risk (AR) for a given statin dose or control (placebo)...
February 6, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29420354/the-rise-and-fall-of-transcranial-doppler-ultrasonography-for-the-diagnosis-of-vasospasm-in-aneurysmal-subarachnoid-hemorrhage
#5
Réza Behrouz
No abstract text is available yet for this article.
February 7, 2018: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/29414883/possible-role-of-inflammation-and-galectin-3-in-brain-injury-after-subarachnoid-hemorrhage
#6
REVIEW
Hirofumi Nishikawa, Hidenori Suzuki
Aneurysmal subarachnoid hemorrhage (SAH) is known as one of the most devastating diseases in the central nervous system. In the past few decades, research on SAH has focused on cerebral vasospasm to prevent post-SAH delayed cerebral ischemia (DCI) and to improve outcomes. However, increasing evidence has suggested that early brain injury (EBI) is an important mechanism contributing to DCI, cerebral vasospasm as well as poor outcomes. Though the mechanism of EBI is very complex, inflammation is thought to play a pivotal role in EBI...
February 7, 2018: Brain Sciences
https://www.readbyqxmd.com/read/29412162/diagnostic-performance-of-different-perfusion-algorithms-for-the-detection-of-angiographical-spasm
#7
Saif Afat, Carolin Brockmann, Omid Nikoubashman, Marguerite Muller, Kolja M Thierfelder, Wolfgang G Kunz, Ulrike Haberland, Marc A Brockmann, Konstantin Nikolaou, Martin Wiesmann, Ahmed E Othman
PURPOSE: To assess the diagnostic utility of different perfusion algorithms for the detection of angiographical arterial spasm. METHOD: During a 2-year period, 45 datasets from 29 patients (54.2±10,75y,20F) with suspected cerebral vasospasm after aneurysmal subarachnoid hemorrhage were included. Volume Perfusion CT (VPCT), Non-enhanced CT (NCT) and angiography were performed within 6hours post-ictus. Perfusion maps were generated using a maximum slope (MS) and a deconvolution-based approach (DC)...
February 2, 2018: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/29410034/repeated-endovascular-treatments-in-patients-with-recurrent-cerebral-vasospasms-after-subarachnoid-hemorrhage-a-worthwhile-strategy
#8
Claudia Ditz, Alexander Neumann, Jann Wojak, Emma Smith, Jan Gliemroth, Volker Tronnier, Jan Küchler
OBJECTIVE: Endovascular interventions in patients with subarachnoid hemorrhage (SAH) and symptomatic cerebral vasospasm (sCVS) are commonly performed. But potential benefits of repeated interventions have not been proven. The aim of this study was to show the potential burden and opportunities of repeated endovascular interventions in case of recurrent sCVS. METHODS: We reviewed 15 patients with SAH who underwent more than 2 endovascular treatments of recurrent sCVS (CVS group) regarding the radiation doses, their clinical course and their functional outcome...
January 31, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29377443/salvinorin-a-ameliorates-cerebral-vasospasm-through-activation-of-endothelial-nitric-oxide-synthase-in-a-rat-model-of-subarachnoid-hemorrhage
#9
Juan Sun, Yan Zhang, Jianfei Lu, Weiguang Zhang, Junhao Yan, Lei Yang, Changman Zhou, Renyu Liu, Chunhua Chen
OBJECTIVES: This study aimed to demonstrate the potential of Salvinorin A (SA) for cerebral vasospasm after subarachnoid hemorrhage (SAH) and investigate mechanisms of therapeutic effect using rat SAH model. METHODS: SA was injected intraperitoneally and the neurobehavioral changes were observed at 24h, 48h and 72h after SAH. Basilar artery was observed by Magnetic Resonance Imaging (MRI). The inner diameter and thickness of basilar artery were measured. The morphological changes and the apoptosis in CA1 area of hippocampus were detected...
January 27, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29373230/hyperperfusion-after-clipping-of-aneurysm-a-rare-entity
#10
Hideaki Nagashima, Tomoru Miwa, Takashi Horiguchi, Ryosuke Tomio, Yu Nakagawa, Kazunari Yoshida
BACKGROUND: Cerebral vasospasm is an uncontrollable and sometimes fatal complication occurring after subarachnoid hemorrhage. However, cerebral hyperperfusion syndrome is a rare complication after subarachnoid hemorrhage. Although plain computed tomography of cerebral hyperperfusion syndrome looks similar to cerebral infarction induced by cerebral vasospasm, they should be distinguished from each other because they require completely different treatments. CASE DESCRIPTION: A 65-year-old man complained of severe headache and vomiting...
January 17, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29355804/continuous-lumbar-cistern-drainage-before-surgical-clipping-for-aneurysmal-subarachnoid-hemorrhage
#11
Ning Xu, Hao Meng, Tianyi Liu, Yingli Feng, Yuan Qi, Honglei Wang
BACKGROUND: Lumbar drainage (LD) is the choice for the treatment of acute hydrocephalus and increased intracranial pressure in patients with subarachnoid hemorrhage (SAH). It also reduces vasospasm risk and delayed ischemic neurological events. We evaluated the role of LD in the preoperative management of patients with aneurysmal SAH (aSAH). PATIENTS AND METHODS: From January 2011 to January 2013, 520 patients with aSAH were subjected to clipping surgery and were prospectively enrolled in this study...
January 17, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29355383/changes-of-cortical-perfusion-in-the-early-phase-of-subarachnoid-bleeding-in-a-rat-model-and-the-role-of-intracranial-hypertension
#12
M Kolar, K Nohejlova, F Duska, J Mares, J Pachl
Brain perfusion is reduced early after subarachnoid hemorrhage (SAH) due to intracranial hypertension and early vasospasm. The contribution of these two mechanisms is unknown. By performing a prophylactic decompressive craniectomy (DC) in a rat model of SAH we aimed to study brain perfusion after the component of intracranial hypertension has been eliminated. We used 2x2 factorial design, where rats received either decompressive craniectomy or sham operation followed by injection of 250 microl of blood or normal saline into prechiasmatic cistern...
December 30, 2017: Physiological Research
https://www.readbyqxmd.com/read/29302799/early-abnormal-transient-hyperemic-response-test-can-predict-delayed-ischemic-neurologic-deficit-in-subarachnoid-hemorrhage
#13
Hosam Al-Jehani, Mark Angle, Judith Marcoux, Jeanne Teitelbaum
BACKGROUND: Early detection of vasospasm is crucial to prevent significant delayed ischemic neurological deficit post subarachnoid hemorrhage. The standard methods of detection, including cerebral angiogram and computed tomography are invasive and not safe to be repeated, as is very often indicated clinically. Transient hyperemic response test has been previously used to predict autoregulation failure in traumatic brain injury and subarachnoid hemorrhage. AIMS: We investigate the usability of transient hyperemic response test as a predictor of clinical vasospasm in a cohort of patients with aneurismal subarachnoid hemorrhage...
January 4, 2018: Critical Ultrasound Journal
https://www.readbyqxmd.com/read/29296615/minocycline-protects-against-delayed-cerebral-ischemia-after-subarachnoid-hemorrhage-via-matrix-metalloproteinase-9-inhibition
#14
Ananth K Vellimana, Meng-Liang Zhou, Itender Singh, Diane J Aum, James W Nelson, Glenn R Harris, Umeshkumar Athiraman, Byung H Han, Gregory J Zipfel
Objective: Delayed cerebral ischemia (DCI) is an independent risk factor for poor outcome after aneurysmal subarachnoid hemorrhage (SAH) and is multifactorial in etiology. While prior studies have suggested a role for matrix metalloproteinase-9 (MMP-9) in early brain injury after SAH, its contribution to the pathophysiology of DCI is unclear. Methods: In the first experiment, wild-type (WT) and MMP-9 -/- mice were subjected to sham or endovascular perforation SAH surgery...
December 2017: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29284568/clinical-characteristics-of-subarachnoid-hemorrhage-with-an-intracerebral-hematoma-and-prognostic-factors
#15
Masaaki Nemoto, Hiroyuki Masuda, Yuki Sakaeyama, Sinichi Okonogi, Yasuhiro Node, Keita Ueda, Shunpei Ando, Kosuke Kondo, Naoyuki Harada, Nobuo Sugo
BACKGROUND: Subarachnoid hemorrhage (SAH) with an intracerebral hematoma (ICH) shows an unfavorable prognosis. In the present study, we examined the characteristics of SAH with ICH and its prognosis. METHODS: Subjects comprised 218 patients with SAH who underwent surgery between January 2007 and December 2015. We compared age, sex, the location of the aneurysm, treatment procedures, medical history (hypertension, diabetes, and heart disease), the Glasgow Coma Scale (GCS) score on admission, rerupture rate, hydrocephalus, the diameter of the aneurysm, cerebral vasospasm, perioperative cardiopulmonary complications, and the Glasgow Outcome Scale (GOS) score after 2 months between patients with SAH with and without ICH...
December 25, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29277532/levels-of-il-1%C3%AE-il-18-and-tnf-%C3%AE-in-cerebrospinal-fluid-of-aneurysmal-subarachnoid-hemorrhage-patients-may-be-predictors-of-early-brain-injury-and-clinical-prognosis
#16
Sheng-Yin Lv, Qi Wu, Jing-Peng Liu, Jiang Shao, Li-Li Wen, Jin Xue, Xiang-Sheng Zhang, Qing-Rong Zhang, Xin Zhang
BACKGROUND: Aneurysmal subarachnoid hemorrhage (aSAH) is a severe cerebrovascular accident with high morbidity and mortality. The aim of this study is to investigate the relationship between level of inflammatory cytokines in cerebrospinal fluid of aSAH patients, the severity of aSAH and the outcome of aSAH patients. METHODS: aSAH patients were prospectively included and followed-up 6 months. CSF samples were collected at 1-3 days, 4-6 days and 7-9 days after aSAH onset, respectively...
December 19, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29274300/unconjugated-bilirubin-modulates-neuronal-signaling-only-in-wild-type-mice-but-not-after-ablation-of-the-r-type-cav-2-3-voltage-gated-calcium-channel
#17
Walid Albanna, Felix Neumaier, Jan Niklas Lüke, Konstantin Kotliar, Catharina Conzen, Ute Lindauer, Jürgen Hescheler, Hans Clusmann, Toni Schneider, Gerrit Alexander Schubert
INTRODUCTION: The relationship between blood metabolites and hemoglobin degradation products (BMHDPs) formed in the cerebrospinal fluid and the development of vasospasm and delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (aSAH) has been the focus of several previous studies, but their molecular and cellular targets remain to be elucidated. METHODS: Because BMHDP-induced changes in Cav 2.3 channel function are thought to contribute to DCI after aSAH, we studied their modulation by unconjugated bilirubin (UCB) in an organotypical neuronal network from wild-type (WT) and Cav 2...
December 23, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29262433/aneurysmal-subarachnoid-hemorrhage-strategies-for-preventing-vasospasm-in-the-intensive-care-unit
#18
Michael N Diringer, Allyson R Zazulia
This article addresses the intensive care unit (ICU) management of patients with aneurysmal subarachnoid hemorrhage (SAH), with an emphasis on the prevention of cerebral vasospasm and delayed cerebral ischemia (DCI), which are major contributors to morbidity and mortality. Interventions addressing various steps in the development of vasospasm have been attempted, with variable success. Enteral nimodipine remains the only approved measure to potentially prevent DCI. Since oral and intravenous administrations are limited by hypotension, direct administration via sustained-release pellets and intraventricular administration of sustained-release microparticles are being investigated...
December 2017: Seminars in Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29243981/assessment-of-intracranial-venous-blood-flow-after-subarachnoid-hemorrhage-a-new-approach-to-diagnose-vasospasm-with-transcranial-color-coded-duplex-sonography
#19
Florian Connolly, Stephan J Schreiber, Christoph Leithner, Georg Bohner, Peter Vajkoczy, José M Valdueza
OBJECTIVE Transcranial color-coded duplex sonography (TCCS) is a reliable tool that is used to assess vasospasm in the M 1 segment of the middle cerebral artery (MCA) after subarachnoid hemorrhage (SAH). A distinct increase in blood flow velocity (BFV) is the principal criterion for vasospasm. The MCA/internal carotid artery (ICA) index (Lindegaard Index) is also widely used to distinguish between vasospasm and cerebral hyperperfusion. However, extracranial ultrasonography assessment of the neck vessels might be difficult in an intensive care unit...
December 15, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29241271/how-reliable-is-pupillary-evaluation-following-subarachnoid-hemorrhage-effect-of-oculomotor-nerve-degeneration-secondary-to-posterior-communicating-artery-vasospasm-first-experimental-study
#20
Cengiz Ozturk, Nuriye Guzin Ozdemir, Ayhan Kanat, Mehmet Dumlu Aydin, Huseyin Findik, Nazan Aydin, Mehmet Esref Kabalar, Hizir Kazdal, Coskun Yolas, Orhan Baykal, Muhammet Calik
No abstract text is available yet for this article.
December 14, 2017: Journal of Neurological Surgery. Part A, Central European Neurosurgery
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