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https://www.readbyqxmd.com/read/28743168/calorie-restriction-reverses-age-related-alteration-of-cavernous-neurovascular-structure-in-the-rat
#1
A Limanjaya, K-M Song, M-J Choi, K Ghatak, N N Minh, D H Kang, J Ock, G N Yin, H Y Chung, J-K Ryu, J-K Suh
Calorie restriction (CR) refers to a reduction of calorie intake without compromising essential nutrients to avoid malnutrition. CR has been established as a non-genetic method of altering longevity and attenuating biological changes associated with aging. Aging is also an important risk factor for erectile dysfunction. The aim of this study was to examine whether CR diet can reverse the age-related alterations of erectile tissue in the aged rat. Four groups of rats were used: young rats (7 months) + ad libitum, aged rats (22 months) + ad libitum, young rats + CR diet, and aged rats + CR diet...
July 25, 2017: Andrology
https://www.readbyqxmd.com/read/28743048/the-ketogenic-diet-in-patients-with-myoclonic-status-in-non-progressive-encephalopathy
#2
Roberto Caraballo, Francesca Darra, Gabriela Reyes, Marisa Armeno, Araceli Cresta, Graciela Mestre, Bernardo Dalla Bernardina
Myoclonic status in non-progressive encephalopathy (MSNPE) is characterized by the recurrence of long-lasting atypical status epilepticus associated with attention impairment and continuous polymorphous jerks, mixed with other complex abnormal movements, in infants suffering from a non-progressive encephalopathy. The ketogenic diet (KD) has been used as an alternative to antiepileptic drugs (AEDs) for patients with refractory epileptic encephalopathies. PURPOSE: In this study we assess the efficacy and tolerability of the KD in patients with MSNPE...
July 11, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28742839/flavonols-reduce-aortic-atherosclerosis-lesion-area-in-apolipoprotein-e-deficient-mice-a-systematic-review-and-meta-analysis
#3
James Phie, Smriti M Krishna, Joseph V Moxon, Safraz M Omer, Robert Kinobe, Jonathan Golledge
Diets rich in flavonoids have been reported to have beneficial effects in the primary prevention of cardiovascular events. There are limited data, however, on the cardiovascular benefits of purified flavonoids. The aim of this systematic review and meta-analysis was to examine the reported effects of isolated flavonoids on aortic atherosclerosis in a mouse model. Medline, Pubmed, Science direct and Web of Science were searched to identify studies which examined the effect of isolated flavonoids on aortic atherosclerosis in apolipoprotein E deficient mice...
2017: PloS One
https://www.readbyqxmd.com/read/28742368/borapetoside-e-a-clerodane-diterpenoid-extracted-from-tinospora-crispa-improves-hyperglycemia-and-hyperlipidemia-in-high-fat-diet-induced-type-2-diabetes-mice
#4
Yuhui Xu, Yanfen Niu, Yuan Gao, Fang Wang, Wanying Qin, Yanting Lu, Jing Hu, Li Peng, Jikai Liu, Wenyong Xiong
An insidious increase in the incidence of obesity, insulin resistance, and hyperlipidemia has led to an epidemic of type 2 diabetes worldwide. Tinospora crispa (T. crispa) is a familiar plant traditionally used in herbal medicine for diabetes; however, the major active ingredients of this plant are still unclear. In this study, we identified the therapeutic effects of borapetoside E, a small molecule extracted from T. crispa, in high-fat-diet (HFD)-induced obesity in mice. The therapeutic effects of borapetoside E in HFD-induced obese mice were assessed physiologically, histologically, and biochemically following intraperitoneal injection...
July 25, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28742311/an-analysis-of-selected-risk-factors-of-osteoporosis-%C3%A2-dietary-patterns-and-physical-activity-%C3%A2-in-pubescent-girls-from-the-lubelskie-province
#5
Anna Czeczuk, Elżbieta Huk-Wieliczuk, Agnieszka Dmitruk, Helena Popławska
INTRODUCTION: Peak bone mass is modulated by intrinsic (genetic) and extrinsic factors, such as diet, physical activity, stimulants and medications. Approximately 80-85% of peak bone mass is achieved during puberty. OBJECTIVE: The aim of the study was to analyze selected risk factors for osteoporosis, specifically diet and physical activity, in 10- to 15-year-old girls. MATERIAL AND METHODS: The study included 461 girls from Eastern Poland (Lublin Province)...
2017: Przegla̧d Epidemiologiczny
https://www.readbyqxmd.com/read/28742010/bacterial-communities-in-the-small-intestine-respond-differently-to-those-in-the-caecum-and-colon-in-mice-fed-low-and-high-fat-diets
#6
Janet C Onishi, Sara Campbell, Michael Moreau, Falshruti Patel, Andrew I Brooks, Yin Xiu Zhou, Max M Häggblom, Judith Storch
Bacterial communities in the mouse caecum and faeces are known to be altered by changes in dietary fat. The microbiota of the mouse small intestine, by contrast, has not been extensively profiled and it is unclear whether small intestinal bacterial communities shift with dietary fat levels. We compared the microbiota in the small intestine, caecum and colon in mice fed a low-fat (LF) or high-fat (HF) diet using 16S rRNA gene sequencing. The relative abundance of major phyla in the small intestine, Bacteriodetes, Firmicutes and Proteobacteria, was similar to that in the caecum and colon; the relative abundance of Verrucomicrobia was significantly reduced in the small intestine compared to the large intestine...
July 26, 2017: Microbiology
https://www.readbyqxmd.com/read/28741972/the-effect-of-zirconium-doping-of-cerium-dioxide-nanoparticles-on-pulmonary-and-cardiovascular-toxicity-and-biodistribution-in-mice-after-inhalation
#7
Susan Dekkers, Mark R Miller, Roel P F Schins, Isabella Römer, Mike Russ, Rob J Vandebriel, Iseult Lynch, Marie-France Belinga-Desaunay, Eugenia Valsami-Jones, Shea P Connell, Ian P Smith, Rodger Duffin, John A F Boere, Harm J Heusinkveld, Catrin Albrecht, Wim H de Jong, Flemming R Cassee
Development and manufacture of nanomaterials is growing at an exponential rate, despite an incomplete understanding of how their physicochemical characteristics affect their potential toxicity. Redox activity has been suggested to be an important physicochemical property of nanomaterials to predict their biological activity. This study assessed the influence of redox activity by modification of cerium dioxide nanoparticles (CeO2 NPs) via zirconium (Zr) doping on the biodistribution, pulmonary and cardiovascular effects in mice following inhalation...
July 25, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28741959/effect-of-epigallocatechin-gallate-on-growth-performance-and-antioxidant-capacity-in-heat-stressed-broilers
#8
Bo Xue, Jiao Song, Longzhou Liu, Jingxian Luo, Guangming Tian, Ye Yang
This study investigated the effects of epigallocatechin gallate (EGCG) on the growth performance and antioxidant capacity of 35-d-old broilers exposed to heat stress. Broilers, 14 d of age, were divided into four groups with six replicates per group (eight chickens/replicate). Thermoneutral group (Group TN) was fed the basal diet and maintained at 28°C for 24 h/d. The heat-stressed groups were housed at 35°C for 12 h/d and 28°C for 12 h/d and fed the basal diet supplemented with EGCG at 0, 300 and 600 mg/kg diet (Groups HS0, HS 300 and HS600, respectively)...
July 25, 2017: Archives of Animal Nutrition
https://www.readbyqxmd.com/read/28741907/nutrition-status-of-children-in-latin-america
#9
C Corvalán, M L Garmendia, J Jones-Smith, C K Lutter, J J Miranda, L S Pedraza, B M Popkin, M Ramirez-Zea, D Salvo, A D Stein
The prevalence of overweight and obesity is rapidly increasing among Latin American children, posing challenges for current healthcare systems and increasing the risk for a wide range of diseases. To understand the factors contributing to childhood obesity in Latin America, this paper reviews the current nutrition status and physical activity situation, the disparities between and within countries and the potential challenges for ensuring adequate nutrition and physical activity. Across the region, children face a dual burden of undernutrition and excess weight...
July 2017: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28741906/a-research-agenda-to-guide-progress-on-childhood-obesity-prevention-in-latin-america
#10
L Kline, J Jones-Smith, J Jaime Miranda, M Pratt, R S Reis, J A Rivera, J F Sallis, B M Popkin
Childhood obesity rates in Latin America are among the highest in the world. This paper examines and evaluates the many efforts underway in the region to reduce and prevent further increases in obesity, identifies and discusses unique research challenges and opportunities in Latin America, and proposes a research agenda in Latin America for the prevention of childhood obesity and concomitant non-communicable diseases. Identified research gaps include biological challenges to healthy growth across the life cycle, diet and physical activity dynamics, community interventions promoting healthy child growth, and rigorous evaluation of national food and activity programs and regulatory actions...
July 2017: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28741804/does-whey-protein-supplementation-improve-the-nutritional-status-in-hypoalbuminemic-peritoneal-dialysis-patients
#11
Kamal Hassan
Limited data are available regarding the effects of whey protein on the nutritional status of the peritoneal dialysis population. This study evaluated the effects of whey protein supplementation for 12 weeks on the nutritional status in hypoalbuminemic peritoneal dialysis patients. Thirty-six stable adult patients on maintenance peritoneal dialysis with serum albumin levels <3.5 g/dL were enrolled in the study and were divided into two groups similar in their serum albumin and normalized protein equivalent of total nitrogen appearance (nPNA)...
July 25, 2017: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/28741793/telomerase-enzyme-deficiency-promotes-metabolic-dysfunction-in-murine-hepatocytes-upon-dietary-stress
#12
Raquel M Alves-Paiva, Sachiko Kajigaya, Xingmin Feng, Jichun Chen, Marie Desierto, Susan Wong, Danielle M Townsley, Flávia S Donaires, Adeline Bertola, Bin Gao, Neal S Young, Rodrigo T Calado
Short telomeres and genetic telomerase defects are risk factors for some human liver diseases, ranging from non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) to cirrhosis. In murine models, telomere dysfunction has been shown to metabolically compromise hematopoietic cells, liver, and heart via the activation of the p53-PGC axis METHODS: Tert- and Terc-deficient mice were challenged with liquid high fat diet (HFD). Liver metabolic contents were analyzed by CE-TOFMS and liver fat content was confirmed by confocal and electronic microscopy RESULTS: Tert-deficient but not Terc-deficient mice develop hepatocyte injury and frank steatosis when challenged with liquid HFD...
July 25, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28741715/first-report-of-carglumic-acid-in-a-patient-with-citrullinemia-type-1-argininosuccinate-synthetase-deficiency
#13
E Kose, P Kuyum, B Aksoy, J Häberle, N Arslan, Y Ozturk
WHAT IS KNOWN AND OBJECTIVE: Carglumic acid is a structural analogue of human N-acetylglutamate, which has become an alternative therapeutic option for hyperammonaemia in organic acidaemias such as isovaleric acidaemia, methylmalonic acidaemia and propionic acidaemia, and it has been suggested in other urea cycle disorders such as ornithine transcarbamylase deficiency and carbamoyl phosphate synthetase 1 deficiency. CASE DESCRIPTION: A male newborn was diagnosed with citrullinemia after serum amino acid analyses revealed markedly elevated citrulline concentration together with homozygous p...
July 25, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28741666/assessment-of-the-potential-of-the-multi-enzyme-producer-bacillus-amyloliquefaciens-us573-as-alternative-feed-additive
#14
Ameny Farhat-Khemakhem, Monia Blibech, Ines Boukhris, Mohamed Makni, Hichem Chouayekh
BACKGROUND: Recently, probiotics have increasingly been used as feed additives in poultry diets as an alternative to antibiotic growth promoters fostering resistance development. RESULTS: This study was aimed at assessing the potential of Bacillus amyloliquefaciens US573 as a direct-fed microbial. The US573 strain was found to be free of harmful enzymatic activities and sensitive to antibiotics. In addition, it showed a good acid and bovine bile tolerance, high adhesion efficacy to chicken enterocytes, and an ability to form biofilms, which may favor its survival and persistence in the animal gastrointestinal tract...
July 25, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28741661/effect-of-dietary-resveratrol-supplementation-on-meat-quality-muscle-antioxidative-capacity-and-mitochondrial-biogenesis-of-broilers
#15
Cheng Zhang, Lei Yang, Xiaohui Zhao, Xingyong Chen, Li Wang, Zhaoyu Geng
BACKGROUND: The naturally occurring polyphenol resveratrol has been acknowledged with many beneficial biological effects. The aim of this study was to evaluate the influence of dietary resveratrol supplementation on meat quality, muscle antioxidative capacity and mitochondrial biogenesis of broilers. One hundred and eighty 21-d-old male Cobb broilers were randomly assigned to two groups and fed on a 0 mg kg(-1) or 400 mg kg(-1) resveratrol-supplemented diet for 21 d. Then, chickens were slaughtered and pectoralis major muscle (PM) samples were collected for analysis...
July 25, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28741614/diet-and-risk-of-cholecystectomy-a-prospective-study-based-on-the-french-e3n-cohort
#16
Amélie Barré, Gaëlle Gusto, Claire Cadeau, Franck Carbonnel, Marie-Christine Boutron-Ruault
OBJECTIVES: This study aimed to examine the relationship between diet and cholecystectomy risk, using three approaches, in a large French cohort. METHODS: In a prospective cohort study in French women who completed a food-frequency questionnaire at baseline, we analyzed diet with three approaches: food groups, dietary patterns obtained by factor analysis, and the Mediterranean diet score. The primary outcome was cholecystectomy. We used Cox proportional hazards regression to assess the relationship between diet and cholecystectomy risk, adjusting for the main potential confounders...
July 25, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28741519/cancer-prevention-lessons-learned-and-future-directions
#17
REVIEW
Barbara K Dunn, Barnett S Kramer
In this review, we address selected areas that are central to the state-of-the-art of cancer prevention science. The emphasis on prevention as a viable and critical approach to decreasing cancer mortality has gained traction in recent years, evidenced by its inclusion in the US Vice President's Cancer Initiative (also termed 'Moonshot'). Cancer prevention occurs by arresting, slowing down, or reversing the carcinogenic process before invasion into surrounding tissue or by avoiding or blocking causative exposure...
December 2016: Trends in Cancer
https://www.readbyqxmd.com/read/28741425/gabapentin-in-the-management-of-pain-following-tonsillectomy-a-randomized-double-blind-placebo-controlled-trial
#18
James G Sanders, Claire Cameron, Patrick J D Dawes
Objective To determine if a single dose of oral gabapentin given prior to tonsillectomy decreases postoperative morbidity. Study Design Prospective randomized double-blind placebo-controlled trial. Setting Southern District Health Board University Hospitals, New Zealand, over a 10-month period. Subjects and Methods Seventy-three adults undergoing tonsillectomy were randomized to receive either a single preoperative dose of oral gabapentin (600 mg) or placebo. A standard analgesic protocol was prescribed for 14 postoperative days...
July 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28741385/efficacy-and-safety-of-teneligliptin-add-on-to-insulin-monotherapy-in-japanese-patients-with-type-2-diabetes-mellitus-a-16-week-randomized-double-blind-placebo-controlled-trial-with-an-open-label-period
#19
Takashi Kadowaki, Kazuoki Kondo, Noriyuki Sasaki, Kyoko Miyayama, Shoko Yokota, Ryuji Terata, Maki Gouda
OBJECTIVE: To assess the efficacy and safety of teneligliptin as add-on to insulin monotherapy in patients with type 2 diabetes mellitus (T2DM). RESEARCH DESIGN AND METHODS: In a 16-week, double-blind period, 148 Japanese T2DM patients with inadequate glycemic control with insulin and diet/exercise therapies were randomized to placebo or teneligliptin 20 mg. In a subsequent 36-week, open-label period, all patients received teneligliptin once daily. The primary outcome measure was change in HbA1c at the end of the double-blind period...
July 25, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28741383/adherence-to-mediterranean-diet-and-metabolic-syndrome-in-brca-mutation-carriers
#20
Eleonora Bruno, Siranoush Manoukian, Elisabetta Venturelli, Andreina Oliverio, Francesca Rovera, Giovanna Iula, Daniele Morelli, Bernard Peissel, Jacopo Azzolini, Eliana Roveda, Patrizia Pasanisi
BACKGROUND: Insulin resistance is associated with higher breast cancer (BC) penetrance in BRCA mutation carriers. Metabolic syndrome (MetS), an insulin resistance syndrome, can be reversed by adhering to the Mediterranean diet (MedDiet). In a dietary intervention trial on BRCA mutation carriers, we evaluated adherence to the MedDiet, and the association with the MetS, by analyzing data from the Mediterranean Diet Adherence Screener (MEDAS). METHODS: BRCA mutation carriers, with or without BC, aged 18 to 70 years, were eligible for the trial...
July 1, 2017: Integrative Cancer Therapies
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