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https://www.readbyqxmd.com/read/29773855/the-anxiolytic-like-effects-of-ginsenoside-rg3-on-chronic-unpredictable-stress-in-rats
#1
Jia-Ning Xu, Li-Fang Chen, Jun Su, Zhi-Li Liu, Jie Chen, Qing-Fen Lin, Wei-Dong Mao, Dong Shen
The present study is to evaluate the anxiolytic-like activities underlying ginsenoside Rg3 (GRg3). The anxiolytic-like activities were induced by GRg3 (20 and 40 mg/kg, i.g), evidenced by blocking the decreased time and entries in the open arms in elevated plus maze test and by reversing the increased latency to feed in novelty-suppressed feeding test. In addition, the decreased levels on progesterone, allopregnanolone, serotonin (5-HT) in the prefrontal cortex and hippocampus of chronic unpredictable stress (CUS) were blocked by GRg3 (20 and 40 mg/kg, i...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29772620/-development-of-ectopic-adrenocorticotropic-hormone-syndrome-in-a-patient-with-prostate-cancer-during-combined-androgen-blockade-therapy
#2
Yosuke Sekii, Mitsuhiro Yoshinaga, Masahiro Nakagawa, Hidefumi Kishikawa, Kazumasa Oka, Kenji Nishimura
A 74-year old man presented to us with difficulty urinating. The laboratory examinations revealed an elevated prostate-specific antigen (PSA) level. A prostate biopsy revealed prostate adenocarcinoma. The computed tomography scan showed metastasis to lymph nodes in the pelvic cavity and both adrenal glands. Combined androgen blockade therapy was started, and PSA levels began to decrease gradually. However, 2 months later, he was hospitalized for treatment of cellulitis and was found to have hypertension, hyperglycemia, and hypokalemia...
April 2018: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/29763783/sex-differences-in-the-acth-and-cortisol-response-to-pharmacological-probes-are-stressor-specific-and-occur-regardless-of-alcohol-dependence-history
#3
Robert M Anthenelli, Jaimee L Heffner, Thomas J Blom, Belinda E Daniel, Benjamin S McKenna, Gary S Wand
Women and men differ in their risk for developing stress-related conditions such as alcohol use and anxiety disorders and there are gender differences in the typical sequence in which these disorders co-occur. However, the neural systems underlying these gender-biased psychopathologies and clinical course modifiers in humans are poorly understood and may involve both central and peripheral mechanisms regulating the limbic-hypothalamic-pituitary-adrenal axis. In the present randomized, double blind, placebo-controlled, triple-dummy crossover study, we juxtaposed a centrally-acting, citalopram (2 mg/unit BMI) neuroendocrine stimulation test with a peripherally-acting, dexamethasone (Dex) (1...
May 4, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29704202/role-of-hpa-and-the-hpg-axis-interaction-in-testosterone-mediated-learned-helpless-behavior
#4
Birgit Ludwig, Bhaskar Roy, Yogesh Dwivedi
Affective disorders show sex-specific differences in prevalence, symptoms, and complications. One hypothesis for this discrepancy is the interaction between the hypothalamic-pituitary-adrenal (HPA) axis and hypothalamic-pituitary-gonadal (HPG) axis. The present study investigates the influence of androgen on the behavioral phenotype and explores how it interacts with HPA axis genes. Gonadectomized (GDX) and GDX rats treated with testosterone propionate (T) were tested for learned helplessness (LH) behavior and compared with tested controls (TC)...
April 28, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29623778/involvement-of-dopamine-system-in-the-regulation-of-the-brain-corticotropin-releasing-hormone-in-paraventricular-nucleus-in-a-rat-model-of-chronic-visceral-pain
#5
Ning-Ning Ji, Jie Kang, Rong Hua, Yong-Mei Zhang
Objective We aimed to investigate the mechanism of paraventricular nucleus (PVN) and ventral tegmental area (VTA) circuit in the pathogenesis of visceral pain-depression with a rat model induced by neonatal and adult colorectal distension (CRD). Methods Neonate male Sprague-Dayley (SD) rats underwent CRD on postnatal days 8, 10, and 12, and when matured, were tested for adult abdominal withdrawal reflex (AWR) scores to assess visceral hypersensitivity. The forced swimming test was employed to evaluate depression-like behaviors...
April 6, 2018: Neurological Research
https://www.readbyqxmd.com/read/29618970/corticotropin-releasing-factor-receptors-modulate-oxytocin-release-in-the-dorsolateral-bed-nucleus-of-the-stria-terminalis-bnst-in-male-rats
#6
Daisy Martinon, Joanna Dabrowska
The neuropeptide oxytocin (OT) plays an important role in the regulation of social and anxiety-like behavior. Our previous studies have shown that OT neurons send projections from the hypothalamus to the dorsolateral bed nucleus of the stria terminalis (BNSTdl ), a forebrain region critically involved in the modulation of anxiety-like behavior. Importantly, these OT terminals in the BNSTdl express presynaptic corticotropin releasing factor (CRF) receptor type 2 (CRFR2). This suggests that CRFR2 might be involved in the modulation of OT release...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29609111/regulation-of-anxiety-like-behavior-and-crhr1-expression-in-the-basolateral-amygdala-by-lmo3
#7
Antonia Savarese, Amy W Lasek
The LIM domain only protein LMO3 is a transcriptional regulator that has been shown to regulate several behavioral responses to alcohol. Specifically, Lmo3 null (Lmo3Z ) mice consume more ethanol in a binge-drinking test and show enhanced ethanol-induced sedation. Due to the high comorbidity of alcohol use and anxiety, we investigated anxiety-like behavior in Lmo3Z mice. Lmo3Z mice spent more time in the open arms of the elevated plus maze compared with their wild-type littermates, but the effect was confounded by reduced locomotor activity...
March 27, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29587720/spontaneous-adrenocorticotropic-hormone-acth-normalisation-due-to-tumour-regression-induced-by-metyrapone-in-a-patient-with-ectopic-acth-syndrome-case-report-and-literature-review
#8
Hideyuki Iwayama, Sho Hirase, Yuka Nomura, Tatsuo Ito, Hiroyuki Morita, Kazuo Otake, Akihisa Okumura, Junko Takagi
BACKGROUND: Ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS) is caused by tumours releasing ACTH. Ectopic ACTH-producing tumour regression is rarely induced using steroidogenesis inhibitors. We presented a case of EAS in which ACTH production by a lung tumour was reduced by metyrapone (MTP) and also reviewed previous cases of ectopic ACTH production suppressed via steroidogenesis inhibition. CASE PRESENTATION: A 71-year-old female with general fatigue, central obesity and impaired glucose tolerance was diagnosed with Cushing's syndrome due to elevated ACTH (192...
March 27, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29576599/new-diagnostic-criteria-of-adrenal-subclinical-cushing-s-syndrome-opinion-from-the-japan-endocrine-society
#9
Toshihiko Yanase, Yutaka Oki, Takuyuki Katabami, Michio Otsuki, Kazunori Kageyama, Tomoaki Tanaka, Hisaya Kawate, Makito Tanabe, Masaru Doi, Yuko Akehi, Takamasa Ichijo
New diagnostic criteria and the treatment policy for adrenal subclinical Cushing's syndrome (SCS) are proposed on behalf of the Japan Endocrine Society. The Japanese version has been published, and the essential contents are presented in this English-language version. The current diagnostic criteria for SCS have elicited two main problems: (i) the relatively low reliability of a low range of serum cortisol essential for the diagnosis by an overnight 1-mg dexamethasone suppression test (DST); (ii) different cutoff values for serum cortisol after a 1-mg DST compared with those of other countries...
March 23, 2018: Endocrine Journal
https://www.readbyqxmd.com/read/29565738/maternal-androgen-excess-and-obesity-induce-sexually-dimorphic-anxiety-like-behavior-in-the-offspring
#10
Maria Manti, Romina Fornes, Xiaojuan Qi, Elin Folmerz, Angelica Lindén Hirschberg, Thais de Castro Barbosa, Manuel Maliqueo, Anna Benrick, Elisabet Stener-Victorin
Maternal polycystic ovary syndrome (PCOS), a condition associated with hyperandrogenism, is suggested to increase anxiety-like behavior in the offspring. Because PCOS is closely linked to obesity, we investigated the impact of an adverse hormonal or metabolic maternal environment and offspring obesity on anxiety in the offspring. The obese PCOS phenotype was induced by chronic high-fat-high-sucrose (HFHS) consumption together with prenatal dihydrotestosterone exposure in mouse dams. Anxiety-like behavior was assessed in adult offspring with the elevated-plus maze and open-field tests...
March 22, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29527918/modulation-of-iris-sphincter-and-ciliary-muscles-by-urocortin-2
#11
M Tavares-Silva, D Ferreira, S Cardoso, A R Raimundo, J Barbosa-Breda, A Leite-Moreira, A Rocha-Sousa
Urocortin 2 (UCN2) is a peptide related to corticotropin-releasing factor, capable of activating CRF-R2. Among its multisystemic effects, it has actions in all 3 muscle subtypes. This study's aim was to determine its potential role in two of the intrinsic eye muscle kinetics. Strips of iris sphincter (rabbit) and ciliary (bovine) muscles were dissected and mounted in isometric force-transducer systems filled with aerated-solutions. Contraction was elicited using carbachol (10(-6) M for iris sphincter, 10(-5) M for ciliary muscle), prior to all testing substances...
March 12, 2018: Physiological Research
https://www.readbyqxmd.com/read/29505471/placebo-effects-across-self-report-clinician-rating-and-objective-performance-tasks-among-women-with-post-traumatic-stress-disorder-investigation-of-placebo-response-in-a-pharmacological-treatment-study-of-post-traumatic-stress-disorder
#12
Gabrielle E Hodgins, Jared G Blommel, Boadie W Dunlop, Dan Iosifescu, Sanjay J Mathew, Thomas C Neylan, Helen S Mayberg, Philip D Harvey
PURPOSE/BACKGROUND: For a drug to acquire Food and Drug Administration approval, it must significantly outperform placebo treatment. In recent years, the placebo effect seems to be increasing in neuropsychiatric conditions. Here, we examine placebo effects across self-reported, clinically rated, and performance-based data from a trial using a corticotropin-releasing hormone receptor type 1 (CRHR1) antagonist for treatment of post-traumatic stress disorder (PTSD). METHODS/PROCEDURES: Women with chronic PTSD were randomized to treatment with either GSK561679, a CRHR1 antagonist, or placebo...
June 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29497387/evaluation-of-alcohol-preference-and-drinking-in-msp-rats-bearing-a-crhr1-promoter-polymorphism
#13
Marian L Logrip, John R Walker, Lydia O Ayanwuyi, Valentina Sabino, Roberto Ciccocioppo, George F Koob, Eric P Zorrilla
Alcoholism is a pervasive societal problem, yet available pharmacotherapies fail to treat most sufferers. The type 1 corticotropin-releasing factor (CRF1 ) receptor has received much attention for its putative role in the progression to alcohol dependence, although at present its success in clinical trials has been limited. Two single-nucleotide polymorphisms in the rat Crhr1 promoter have been identified in the Marchigian substrain of Sardinian alcohol-preferring (msP) rats. Unlike other Wistar-derived alcohol-preferring lines, nondependent msP rats reduce their alcohol self-administration in response to CRF1 antagonists and show increased brain CRF1 expression...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29496779/anti-diuretic-action-of-a-capa-neuropeptide-against-a-subset-of-diuretic-hormones-in-the-disease-vector-aedes-aegypti
#14
Farwa Sajadi, Carmela Curcuruto, Afra Al Dhaheri, Jean-Paul V Paluzzi
The mosquito Aedes aegypti is a vector responsible for transmitting various pathogens to humans, and their prominence as chief vectors of human disease is largely due to their anthropophilic blood feeding behaviour. Larval stage mosquitoes must deal with the potential dilution of their haemolymph in freshwater, whereas the haematophagus A. aegypti female faces the challenge of excess ion and water intake after a blood meal. The excretory system, composed of the Malpighian tubules (MTs) and hindgut, is strictly controlled by neuroendocrine factors, responsible for the regulation of diuresis across all developmental stages...
April 6, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29495899/cortical-thinning-and-neuropsychiatric-outcomes-in-children-exposed-to-prenatal-adversity-a-role-for-placental-crh
#15
Curt A Sandman, Megan M Curran, Elysia Poggi Davis, Laura M Glynn, Kevin Head, Tallie Z Baram
OBJECTIVE: The authors sought to assess associations among early-life exposure to adversity, the development and maturation of neurons and brain circuits, and neurodevelopmental outcomes. Specifically, they examined whether fetal exposure to placental corticotropin-releasing hormone (CRH), a molecule conveying maternal signals to the fetus, predicts brain growth and neuropsychiatric outcomes in school-age children. METHOD: In a large, well-characterized prospective cohort, concentrations of placental CRH (pCRH) in maternal plasma were determined during five intervals during gestation...
May 1, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29477300/maternal-stress-and-the-mpoa-activation-of-crf-receptor-1-impairs-maternal-behavior-and-triggers-local-oxytocin-release-in-lactating-rats
#16
Stefanie M Klampfl, Milena M Schramm, Barbara M Gaßner, Katharina Hübner, Audrey F Seasholtz, Paula J Brunton, Doris S Bayerl, Oliver J Bosch
Maternal behavior and anxiety are potently modulated by the brain corticotropin-releasing factor (CRF) system postpartum. Downregulation of CRF in limbic brain regions is essential for appropriate maternal behavior and an adaptive anxiety response. Here, we focus our attention on arguably the most important brain region for maternal behavior, the hypothalamic medial preoptic area (MPOA). Within the MPOA, mRNA for CRF receptor subtype 1 (protein: CRFR1, gene: Crhr1) was more abundantly expressed than for subtype 2 (protein: CRFR2, gene: Crhr2), however expression of Crhr1, Crhr2 and CRF-binding protein (protein: CRFBP, gene: Crhbp) mRNA was similar between virgin and lactating rats...
May 1, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29450857/hypokalemia-associated-with-pseudo-cushing-s-syndrome-and-magnesium-deficiency-induced-by-chronic-alcohol-abuse
#17
Masafumi Kurajoh, Keiko Ohsugi, Miki Kakutani-Hatayama, Takuhito Shoji, Hidenori Koyama
Hypokalemia and hypomagnesemia are frequently observed in patients with chronic alcoholism. However, the involvement of deranged cortisol regulation in patients with those conditions has not been reported. A 63-year-old Japanese male with chronic alcoholism was referred to the Department of Diabetes, Endocrinology and Metabolism for examination and treatment of hypokalemic periodic paralysis. Laboratory findings showed hypokalemia (2.3 mmol/l), as well as a high level of urinary excretion of potassium and hypomagnesemia (1...
May 2018: CEN Case Reports
https://www.readbyqxmd.com/read/29449045/how-to-measure-glucocorticoid-receptor-s-sensitivity-in-patients-with-stress-related-psychiatric-disorders
#18
REVIEW
Carolin Leistner, Andreas Menke
Stress is a state of derailed homeostasis and a main environmental risk factor for psychiatric diseases. Chronic or uncontrollable stress may lead to a dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, which is a common feature of stress-related psychiatric disorders. One of the key mechanisms underlying a disturbed HPA axis is an impaired function of the glucocorticoid receptor (GR) with an enhanced or reduced feedback sensitivity for glucocorticoids and subsequently altered concentrations of peripheral cortisol...
May 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29438489/transient-anosmia-induces-depressive-like-and-anxiolytic-like-behavior-and-reduces-amygdalar-corticotropin-releasing-hormone-in-a-znso4-induced-mouse-model
#19
Sangzin Ahn, Mooseok Choi, Hyunju Kim, Eun-Jeong Yang, Usman Mahmood, Seong-Il Kang, Hyun-Woo Shin, Dae Woo Kim, Hye-Sun Kim
Olfactory loss is known to affect both mood and quality of life. Transient anosmia was induced in mice to study the resulting changes in mood, behavior, and on a molecular level. Transient anosmia was induced by a single intranasal instillation of ZnSO4 in BALB/c mice. Hematoxylin and eosin (HE) staining, and potato chip finding test were performed to confirm olfactory loss. Tail suspension, forced swim, and splash tests were performed to evaluate depression-related behavior; while the open field, and elevated plus maze tests were used to evaluate anxiety-related behavior...
April 23, 2018: Chemical Senses
https://www.readbyqxmd.com/read/29417477/microrna-34-contributes-to-the-stress-related-behavior-and-affects-5-ht-prefrontal-gaba-amygdalar-system-through-regulation-of-corticotropin-releasing-factor-receptor-1
#20
Diego Andolina, Matteo Di Segni, Alessandra Accoto, Luisa Lo Iacono, Antonella Borreca, Donald Ielpo, Nicola Berretta, Emerald Perlas, Stefano Puglisi-Allegra, Rossella Ventura
Recent studies show that microRNA-34 (miR-34) family is critical in the regulation of stress response also suggesting that it may contribute to the individual responsiveness to stress. We have recently demonstrated that mice carrying a genetic deletion of all miR-34 isoforms (triple knockout, TKO) lack the stress-induced serotonin (5-HT) and GABA release in the medial prefrontal cortex (mpFC) and basolateral amygdala (BLA), respectively. Here, we evaluated if the absence of miR-34 was also able to modify the stress-coping strategy in the forced swimming test...
February 7, 2018: Molecular Neurobiology
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