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https://www.readbyqxmd.com/read/27889892/effects-of-mental-stress-induction-on-heart-rate-variability-in-patients-with-panic-disorder
#1
Katja Petrowski, Susann Wichmann, Timo Siepmann, Stefan R Bornstein, Martin Siepmann
Reduced heart rate variability (HRV) constitutes a widely used marker of cardiac autonomic inflexibility which has been linked to disorders such as panic disorder (PD). To date, the pathophysiological mechanisms whereby panic leads to attenuated HRV are not fully elucidated. We aimed to investigate the hypothesis that PD patients show pathological reactivity both in response to interoceptive and psychosocial stress in comparison to healthy individuals. We performed a controlled study on 38 patients diagnosed with PD [20 males and 18 females aged 35...
November 26, 2016: Applied Psychophysiology and Biofeedback
https://www.readbyqxmd.com/read/27888772/adrenocortical-sensitivity-moderated-by-ongoing-stress-predicts-drinking-intensity-in-alcohol-dependent-men
#2
Bryon Adinoff, David Leonard, Julianne Price, Martin A Javors, Robrina Walker, E Sherwood Brown, Hong Xiao, Uma Rao
Allostatic load from both environmental stressors and persistent glucocorticoid secretion has been associated with disease severity in alcohol dependence. Heightened relapse risk and/or drinking severity, in particular, may be a reaction to alcohol- and withdrawal-induced changes in physiological stress response systems coupled with ongoing life stress, although their shared contributions upon drinking severity have not been assessed. To investigate the combined contribution of hypothalamic-pituitary-adrenal (HPA) reactivity and environmental stressors (e...
November 5, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27837170/differential-contributions-of-vasopressin-v1a-and-oxytocin-receptors-in-the-amygdala-to-pain-related-behaviors-in-rats
#3
Bryce Cragg, Guangchen Ji, Volker Neugebauer
Neuroplastic changes in the amygdala account for emotional-affective aspects of pain and involve neuropeptides such as calcitonin gene-related peptide and corticotropin-releasing factor. Another neuropeptide system, central arginine vasopressin, has been implicated in neuropsychiatric disorders, but its role in pain-related emotional expression and neuroplasticity remains to be determined. Here, we tested the hypothesis that arginine vasopressin in the amygdala contributes to pain-related emotional-affective responses, using stereotaxic applications of arginine vasopressin and antagonists for G-protein coupled vasopressin V1A and oxytocin receptors in adult male Sprague-Dawley rats...
2016: Molecular Pain
https://www.readbyqxmd.com/read/27825409/clinical-features-of-pituitary-stalk-interruption-syndrome-in-114-cases
#4
Bai-Yu Han, Qian Zhang, Le-Le Li, Qing-Hua Guo, Cheng-Zhi Wang, Li Cang, Nan Jin, Fang Chen, Ling Zhao, Jia Cui, Xiu-Lian Gu, Fang-Ling Ma, Sai-Chun Zhang, Yi-Ming Mu, Jing-Tao Dou
Objective To analyze the clinical characteristics of pituitary stalk interruption syndrome(PSIS). Methods The clinical data including clinical manifestations,laboratory tests,and imaging findings of 114 PSIS patients in our hospital were retrospectively analyzed. Results Of these 114 PSIS patients,102 cases (89.4%) were male. The average age was 21.1?6.1 years. A history of breech delivery was documented in 91 cases (91.9%). Short stature was found in 89 cases (71.8%) and bone age delayed (6.1?5.1) years. Secondary sex characteristics were poor or undeveloped in most patients...
October 10, 2016: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/27784851/postpartum-hypothalamic-adrenal-insufficiency-with-remission-a-rare-case
#5
Yuko Akehi, Yoko Hashimoto, Junko Meren, Makito Tanabe, Takashi Nomiyama, Toshihiko Yanase
A 37-year-old female patient was hospitalized because of general fatigue and loss of axillary and pubic hair after massive bleeding at delivery of her third child. The basal levels of both plasma adrenocorticotropin hormone (ACTH) and serum cortisol were very low, 5.2 pg/mL and 1.9 μg/dL, respectively. Based on the fact that ACTH showed a low response to insulin tolerance test and a normal response to corticotropin-releasing hormone (CRH), she was diagnosed with hypothalamic adrenal insufficiency. No organic lesions were found in the hypothalamic-pituitary region by pituitary MRI and hydrocortisone therapy was instituted...
October 25, 2016: Endocrine Journal
https://www.readbyqxmd.com/read/27779480/involvement-of-corticotropin-releasing-factor-receptors-type-2-located-in-periaquaductal-gray-matter-in-central-and-peripheral-crf-induced-analgesic-effect-on-somatic-pain-sensitivity-in-rats
#6
N I Yarushkina, T R Bagaeva, L P Filaretova
Corticotropin-releasing factor (CRF) is involved in the regulation of pain sensitivity and can induce an analgesic effect in animals and humans. The periaqueductal gray matter (PAGM) of the midbrain is one of the key structures of the antinociceptive system. The aim of the study was to investigate the involvement of CRF receptor type 2 (CRF-R2 receptors), localized in the PAGM, in the analgesic effect caused by central or systemic CRF on somatic pain sensitivity in conscious rats. Somatic pain sensitivity was tested by a tail flick test (measuring tail flick latency induced by tail's thermal stimulation)...
August 2016: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/27752081/corticotropin-releasing-factor-overexpression-gives-rise-to-sex-differences-in-alzheimer-s-disease-related-signaling
#7
D A Bangasser, H Dong, J Carroll, Z Plona, H Ding, L Rodriguez, C McKennan, J G Csernansky, S H Seeholzer, R J Valentino
Several neuropsychiatric and neurodegenerative disorders share stress as a risk factor and are more prevalent in women than in men. Corticotropin-releasing factor (CRF) orchestrates the stress response, and excessive CRF is thought to contribute to the pathophysiology of these diseases. We previously found that the CRF1 receptor (CRF1) is sex biased whereby coupling to its GTP-binding protein, Gs, is greater in females, whereas β-arrestin-2 coupling is greater in males. This study used a phosphoproteomic approach in CRF-overexpressing (CRF-OE) mice to test the proof of principle that when CRF is in excess, sex-biased CRF1 coupling translates into divergent cell signaling that is expressed as different brain phosphoprotein profiles...
October 18, 2016: Molecular Psychiatry
https://www.readbyqxmd.com/read/27717050/transient-and-persistent-behavioral-and-molecular-changes-in-primiparous-female-wistar-rats
#8
Roshan R Naik, Trynke R de Jong
Motherhood brings about a multitude of behavioral and physiological changes in dams and some of these persist until after weaning. We studied behavioral changes associated with reproductive experience at lactating day (LD)8, at weaning (LD21), and 28 days post-weaning (PW28) compared to nulliparous (NP) females. Furthermore, in another cohort of animals, we quantified mRNA expression of five target genes known to be associated with maternal experience: arginin-vasopressin(Avp) and its 1A receptor(Avpr1a), oxytocin(Oxt) and its receptor(Oxtr), and corticotropin-releasing hormone(Crh) in three key maternal region: the medial preoptic area (MPOA), bed nucleus of the stria terminalis (BNST) and paraventricular hypothalamic nucleus(PVN)...
September 26, 2016: European Journal of Neuroscience
https://www.readbyqxmd.com/read/27716949/skin-exposure-to-ultraviolet-b-rapidly-activates-systemic-neuroendocrine-and-immunosuppressive-responses
#9
Cezary Skobowiat, Arnold E Postlethwaite, Andrzej T Slominski
The back skin of C57BL/6 mice was exposed to a single 400 mJ cm(-2) dose of ultraviolet B (UVB), and parameters of hypothalamic-pituitary-adrenal (HPA) axis in relation to immune activity were tested after 30-90 min following irradiation. Levels of brain and/or plasma corticotropin-releasing hormone (CRH), β-endorphin, ACTH and corticosterone (CORT) were enhanced by UVB. Hypophysectomy had no effect on UVB-induced increases of CORT. Mitogen-induced IFNγ production by splenocytes from UVB-treated mice was inhibited at 30, 90 min and after 24 h...
September 26, 2016: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/27693397/selective-crf2-receptor-agonists-ameliorate-the-anxiety-and-depression-like-state-developed-during-chronic-nicotine-treatment-and-consequent-acute-withdrawal-in-mice
#10
Zsolt Bagosi, Miklós Palotai, Balázs Simon, Péter Bokor, András Buzás, Beáta Balangó, Dávid Pintér, Miklós Jászberényi, Krisztina Csabafi, Gyula Szabó
The aim of the present study was to investigate the effects of the selective agonists of the corticotropin-releasing factor (CRF) 2 receptor, urocortin 2 (UCN 2) and urocortin 3 (UCN 3), on the anxiety- and depression-like signs induced by acute nicotine withdrawal in mice. In order to do so, male CFLP mice were exposed for 7 days to repeated intraperitoneal (IP) injection with nicotine or saline solution and 1day of acute withdrawal and then a single intracerebroventricular (ICV) injection with UCN 2, UCN 3 or saline solution...
September 29, 2016: Brain Research
https://www.readbyqxmd.com/read/27690274/activation-of-adenylate-cyclase-cyclic-amp-protein-kinase-a-signaling-by-corticotropin-releasing-factor-within-the-dorsolateral-bed-nucleus-of-the-stria-terminalis-is-involved-in-pain-induced-aversion
#11
Tomoyuki Kaneko, Katsuyuki Kaneda, Atsushi Ohno, Daiki Takahashi, Taiki Hara, Taiju Amano, Soichiro Ide, Mitsuhiro Yoshioka, Masabumi Minami
Pain is a complex experience involving sensory and affective components. Although the neuronal mechanisms underlying the sensory component of pain have been extensively studied, those underlying its affective component have yet to be elucidated. Recently, we reported that corticotrophin-releasing factor (CRF)-induced depolarization in type II neurons within the dorsolateral bed nucleus of the stria terminalis (dlBNST) is critical for pain-induced aversive responses in rats. However, the intracellular signaling underlying the excitatory effects of CRF and the contribution of such signaling to the induction of pain-induced aversion remain unclear...
September 30, 2016: European Journal of Neuroscience
https://www.readbyqxmd.com/read/27647959/the-antidepressant-effect-of-l-tyrosine-loaded-nanoparticles-behavioral-aspects
#12
Abdelrahman Alabsi, Adel Charbel Khoudary, Wassim Abdelwahed
BACKGROUND: Depression has been linked to disruption in the cerebral levels of specific neurotransmitters. L-tyrosine is a precursor of more than one of the neurotransmitters affected by depression. Even though setbacks of monoamines precursors include high doses and low efficiency, many studies have suggested using L-tyrosine as antidepressant. PURPOSE: The purpose of this study was to explore the possible antidepressant effect of L-tyrosine loaded in a nanoparticle-designed formula, using behavioral tests in acute and chronic mild stress (CMS) models of depression in rats...
July 2016: Annals of Neurosciences
https://www.readbyqxmd.com/read/27637621/acute-central-effects-of-corticotropin-releasing-factor-crf-on-energy-balance-effects-of-age-and-gender
#13
Judit Tenk, Ildikó Rostás, Nóra Füredi, Alexandra Mikó, Szilvia Soós, Margit Solymár, Balázs Gaszner, Miklós Székely, Erika Pétervári, Márta Balaskó
Previously demonstrated age-related changes in the catabolic melanocortin system that may contribute to middle-aged obesity and aging anorexia, raise the question of the potential involvement of corticotropin-releasing factor (CRF) in these phenomena, as this catabolic hypothalamic mediator acts downstream to melanocortins. Catabolic effects of CRF were shown to be mediated by both CRF1 (hypermetabolism) and CRF2 (anorexia) receptors. To test the potential role of CRF in age-related obesity and aging anorexia, we investigated acute central effects of the peptide on energy balance in male and female rats during the course of aging...
September 13, 2016: Peptides
https://www.readbyqxmd.com/read/27609609/neurochemical-factors-associated-with-the-antidepressant-like-effect-of-flavonoid-chrysin-in-chronically-stressed-mice
#14
Carlos Borges Filho, Cristiano Ricardo Jesse, Franciele Donato, Lucian Del Fabbro, Marcelo Gomes de Gomes, André Tiago Rossito Goes, Leandro Cattelan Souza, Renata Giacomeli, Michelle Antunes, Cristiane Luchese, Silvane Souza Roman, Silvana Peterini Boeira
Chrysin is a flavonoid which is found in bee propolis, honey and various plants. Antidepressant-like effect of chrysin in chronically stressed mice was previously demonstrated by our group. Conversely, neurochemical factors associated with this effect require further investigations. Thus, we investigated the possible involvement of pro-inflammatory cytokines, kynurenine pathway (KP), 5-hydroxytryptamine (5-HT) metabolism and caspases activities in the effect of chrysin in mice exposed to unpredictable chronic stress (UCS)...
September 5, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27605249/distinct-roles-of-exogenous-opioid-agonists-and-endogenous-opioid-peptides-in-the-peripheral-control-of-neuropathy-triggered-heat-pain
#15
Dominika Labuz, Melih Ö Celik, Andreas Zimmer, Halina Machelska
Neuropathic pain often results from peripheral nerve damage, which can involve immune response. Local leukocyte-derived opioid peptides or exogenous opioid agonists inhibit neuropathy-induced mechanical hypersensitivity in animal models. Since neuropathic pain can also be augmented by heat, in this study we investigated the role of opioids in the modulation of neuropathy-evoked heat hypersensitivity. We used a chronic constriction injury of the sciatic nerve in wild-type and opioid peptide-knockout mice, and tested opioid effects in heat and mechanical hypersensitivity using Hargreaves and von Frey tests, respectively...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27595147/effect-of-the-crf1-receptor-antagonist-pexacerfont-on-stress-induced-eating-and-food-craving
#16
David H Epstein, Ashley P Kennedy, Melody Furnari, Markus Heilig, Yavin Shaham, Karran A Phillips, Kenzie L Preston
RATIONALE: In rodents, antagonism of receptors for corticotropin-releasing factor (CRF) blocks stress-induced reinstatement of drug or palatable food seeking. OBJECTIVE: To test anticraving properties of the CRF1 antagonist pexacerfont in humans. METHODS: We studied stress-induced eating in people scoring high on dietary restraint (food preoccupation and chronic unsuccessful dieting) with body-mass index (BMI) >22. In a double-blind, between-groups trial, 31 "restrained" eaters were stabilized on either pexacerfont (300 mg/day for 7 days, then 100 mg/day for 21 days) or placebo...
September 5, 2016: Psychopharmacology
https://www.readbyqxmd.com/read/27593282/effects-of-zno-nanoparticles-on-perfluorooctane-sulfonate-induced-thyroid-disrupting-on-zebrafish-larvae
#17
Jia Du, Shutao Wang, Hong You, Zhongqiang Liu
Perfluorooctane sulfonate (PFOS) and ZnO nanoparticles (nano-ZnO) are widely distributed in the environment. However, the potential toxicity of co-exposure to PFOS and nano-ZnO remains to be fully elucidated. The test investigated the effects of co-exposure to PFOS and nano-ZnO on the hypothalamic-pituitary-thyroid (HPT) axis in zebrafish. Zebrafish embryos were exposed to a combination of PFOS (0.2, 0.4, 0.8mg/L) and nano-ZnO (50mg/L) from their early stages of life (0-14days). The whole-body content of TH and the expression of genes and proteins related to the HPT axis were analyzed...
September 2016: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/27582123/clinical-application-of-dex-crh-test-and-multi-channel-nirs-in-patients-with-depression
#18
Shinya Kinoshita, Tetsufumi Kanazawa, Hiroki Kikuyama, Hiroshi Yoneda
BACKGROUND: To reduce the number of patients with depression, biomarkers for clarifying psychiatric disorders are warranted. Numerous candidates have been proposed; however, near-infrared spectroscopy (NIRS) with multi-channel probes and a dexamethasone/corticotropin-releasing hormone (DEX/CRH) test are still surviving for practical demand. Thirty-one outpatients with depressed moods were analyzed using both biological tests. RESULTS: The non-suppressors, as indicated by the DEX/CRH test, exhibited a high severity on the Hamilton Depression Scale and severe anxiety on the State Trait Anxiety Scale...
2016: Behavioral and Brain Functions: BBF
https://www.readbyqxmd.com/read/27544317/effects-of-corticotropin-releasing-hormone-receptor-1-snps-on-major-depressive-disorder-are-influenced-by-sex-and-smoking-status
#19
Bruna S da Silva, Diego L Rovaris, Jaqueline B Schuch, Nina R Mota, Renata B Cupertino, Angelita P Aroche, Guilherme P Bertuzzi, Rafael G Karam, Eduardo S Vitola, Luciana Tovo-Rodrigues, Eugenio H Grevet, Claiton H D Bau
BACKGROUND: The corticotropin-releasing hormone receptor 1 (CRHR1) gene has been repeatedly implicated in Major Depressive Disorder (MDD) in humans and animal models; however, the findings are not absolutely convergent. Since recent evidence from genome-wide association studies suggests that narrowing the phenotypic heterogeneity may be crucial in genetic studies of MDD, the aim of this study was to evaluate the effects of CRHR1 polymorphisms on MDD while addressing the influence of sex and smoking status...
November 15, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27543446/corticotropin-releasing-factor-in-the-locus-coeruleus-as-a-modulator-of-ventilation-in-rats
#20
Jolene M Incheglu, Kênia Cardoso Bícego, Luciane H Gargaglioni
The locus coeruleus (LC) is a pontine noradrenergic nucleus that acts as a central chemoreceptor to CO2/pH and has been implicated in the cognitive aspects of stress responses. This participation is in part mediated by the action of corticotropin-releasing factor (CRF), which when released in these situations increases the firing frequency of LC noradrenergic neurons. Nevertheless, the role of CRF1 receptors in the LC in breathing and temperature control is unknown. Therefore, we tested the involvement of CRF1 receptors located in the LC in room air ventilation and the ventilatory response induced by hypercapnia (7% CO2) in rats...
November 2016: Respiratory Physiology & Neurobiology
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