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(Cutaneous metastasis) -melanoma

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https://www.readbyqxmd.com/read/28228711/cutaneous-metastasis-from-breast-tumour-seeding-in-percutaneous-needle-biopsy
#1
Imma Savarese, Federica Scarfì, Alessia Gori, Federica Papi, Antonietta D'Errico, Marta Grazzini, Piero Covarelli, Vincenzo De Giorgi
No abstract text is available yet for this article.
December 2016: Breast Care
https://www.readbyqxmd.com/read/28223766/cutaneous-implantation-metastasis-of-papillary-thyroid-carcinoma-following-fine-needle-aspiration-biopsy
#2
Chan Ho Na, Dong Jin Kim, Min Sung Kim, Bong Seok Shin
No abstract text is available yet for this article.
February 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28217487/cutaneous-metastasis-from-prostate-carcinoma
#3
Savera Gupta, Manjaree Morgaonkar, Suresh K Jain
No abstract text is available yet for this article.
January 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/28203164/successful-treatment-of-advanced-primary-cutaneous-apocrine-carcinoma-on-the-scrotum-with-systemic-chemotherapy-and-radiotherapy-followed-by-denosumab
#4
Sadanori Furudate, Taku Fujimura, Akira Tsukada, Yota Sato, Takanori Hidaka, Kayo Tanita, Yumi Kambayashi, Takahiro Haga, Akira Hashimoto, Setsuya Aiba
Primary cutaneous apocrine carcinoma (PCAC) is a rare and highly aggressive cutaneous adnexal type of tumor that has a high metastasis rate and a poor prognosis. Although there are several case reports describing the successful treatment of PCAC with chemoradiotherapy or molecular targeting therapy, no standard therapy for the treatment of advanced PCAC has been established yet. Since receptor activator of nuclear factor kappa-B ligand (RANKL) is expressed in cancers of apocrine origin, leading to immunosuppression at the tumor site, we hypothesized that targeting RANKL with denosumab might be useful for the treatment of PCAC...
January 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28202188/rate-of-regional-nodal-metastases-of-cutaneous-squamous-cell-carcinoma-in-the-immunosuppressed-patient
#5
Eamon J McLaughlin, Lauren Miller, Thuzar M Shin, Joseph F Sobanko, Steven B Cannady, Christopher J Miller, Jason G Newman
PURPOSE: Immunosuppressed solid organ transplant recipients (SOTRs) have an increased risk of developing cutaneous squamous cell carcinomas (cSCCs) with metastatic potential. This study sought to determine the rate of regional lymph node involvement in a large cohort of solid organ transplant patients with cutaneous head and neck squamous cell carcinoma. MATERIALS AND METHODS: A retrospective chart review was performed on solid organ transplant patients with head and neck cutaneous squamous cell carcinoma treated at a tertiary academic medical center from 2005 to 2015...
February 4, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28157733/squamous-cell-carcinoma-of-the-lip-a-review-of-squamous-cell-carcinogenesis-of-the-mucosal-and-cutaneous-junction
#6
James P Bota, Alexis B Lyons, Bryan T Carroll
BACKGROUND: The lip is an anatomic junction for 2 disparate groups of cancer. Cutaneous squamous cell carcinoma (cSCC) is a common malignancy with a favorable prognosis, whereas oral-mucosal squamous cell carcinoma (omSCC) is associated with significantly higher rates of nodal disease and worse outcomes. The squamous cell carcinoma of the lip (lip SCC) is more aggressive than cSCC but less aggressive than omSCC. However, work-up and treatment vary between specialties. OBJECTIVES: The authors sought to review and compare the risk factors and clinical behavior of cSCC, omSCC, and lip SCC, review tumor biology of squamous cell carcinoma, and compare work-up and treatment algorithms for lip SCC...
February 1, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28149222/merkel-cell-carcinoma-of-the-hand-a-case-report-and-review-of-the-literature
#7
Donevan R Westerveld, David J Hall, Winston T Richards
Background: Merkel cell carcinoma (MCC) is a relatively rare and aggressive cutaneous neuroendocrine malignancy characterized by high incidence of local recurrence, distant metastases, regional nodal metastases, and high mortality. Clinically, MCC presents as a persistent asymptomatic red/pink shaped nodule, usually smaller than 2 cm with nontender intracutaneous swelling, with rapidly growing localized disease with lymph node metastases preceding distant metastases. Because of its rare nature and the lack of comprehensive understanding of the disease, management of MCC has been controversial...
December 2016: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28133319/-two-year-recurrence-free-survival-after-resection-of-cutaneous-metastasis-from-pancreatic-cancer-a-case-report
#8
Takahiko Tanigawa, Yasunori Hasuike, Yousuke Akiyama, Ichiro Higuchi, Akira Ishikawa, Sanae Hosomi, Makoto Miyamoto
The patient was a 73-year-old woman who underwent distalpancreatectomy for pancreas tailcancer (T3, N0, M0, stage III ). Hepatic arterialinfusion(HAI)using high-dose 5-fluorouracil(5-FU)(6,000mg/week)was performed 35 days after curative resection to prevent liver metastases. Although chemotherapy with gemcitabine(GEM)was administered for 2 weeks, the patient was aware of a nodule(1 cm in diameter)on the right lower quadrant of the abdomen. Resection of the cutaneous mass was performed and histological findings revealed metastatic adenocarcinoma from the pancreas cancer...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28130284/metastatic-endometrial-endometrioid-carcinoma-mimicking-pilomatrixoma-of-the-distal-vagina
#9
Simon M Scheck, Peter Bethwaite, Carol Johnson, Ole Mogensen
Endometrioid carcinoma with a prominent squamous component has the ability to mimic pilomatrixoma. One previous case is documented of cutaneous metastasis in the upper limb derived from ovarian endometrioid carcinoma mimicking pilomatrixoma. Here, we describe a case of metastasis of endometrial endometrioid carcinoma in the distal vagina, treated with radiotherapy and later resected. The histology of the lesion was thought initially to represent pilomatrixoma; this has not previously been described in the vagina, where no hair matrix cells are normally present...
January 27, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28128082/a-giant-basal-cell-carcinoma-misdiagnosed-and-mistreated-as-a-chronic-venous-ulcer
#10
Dijana Celić, Jasna Lipozenčić, Suzana Ljubojević Hadžavdić, Jolanda Kanižaj Rajković, Davorin Lončarić, Tajana Borlinić
Basal cell carcinoma (BCC) is the most common cutaneous malignancy. Giant BCCs are quite rare. They can cause extensive local invasion, disfigurement, and metastasis. We present a case of a 58-year-old woman with an unrecognized and inadequately treated ulcerated giant BCC sized 12.5 × 10.0 cm that occurred on her left lower leg without any sign of metastasis. Neglect and inadequate treatment of the primary lesion are the most important contributing factors responsible for size in giant BCC.
December 2016: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/28119994/placental-growth-factor-and-vascular-endothelial-growth-factor-together-regulate-tumour-progression-via-increased-vasculature-in-cutaneous-t-cell-lymphoma
#11
Tomomitsu Miyagaki, Makoto Sugaya, Tomonori Oka, Naomi Takahashi, Makiko Kawaguchi, Hiraku Suga, Hideki Fujita, Ayumi Yoshizaki, Yoshihide Asano, Shinichi Sato
Angiogenesis is regarded as an essential step in supporting tumour growth and metastasis. In haematological malignancies, including cutaneous T cell lymphoma (CTCL), angiogenesis is increased and serum levels of some pro-angiogenic markers are elevated. The aim of this study was to investigate expression levels of placental growth factor (PlGF) and vascular endothelial growth factor (VEGF)-A in lesional skin and sera in patients with CTCL, and to assess the association of these factors with development of CTCL...
January 25, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28118230/investigation-of-prognostic-features-in-primary-cutaneous-and-soft-tissue-angiosarcoma-after-surgical-resection-a-retrospective-study
#12
Biing Luen Lee, Cheng-Feng Chen, Paul Chih-Hsueh Chen, Hui-Chen Lee, Wen-Chieh Liao, Chern-Kang Perng, Hsu Ma, Chih-Hsun Lin
Primary cutaneous and soft tissue angiosarcoma is a rare but highly aggressive malignancy. To date, surgical resection is the mainstay of treatment, but poor prognosis is expected. To investigate whether there are factors associated with poor prognosis after surgical resection and to develop a treatment guideline for current therapy, we retrospectively collected data on 28 patients who underwent surgery as initial treatment and reviewed patient demographics, tumor characteristics, disease courses, and prognoses from September 1996 to May 2013...
January 23, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28110712/research-techniques-made-simple-analysis-of-collective-cell-migration-using-the-wound-healing-assay
#13
Ayman Grada, Marta Otero-Vinas, Francisco Prieto-Castrillo, Zaidal Obagi, Vincent Falanga
Collective cell migration is a hallmark of wound repair, cancer invasion and metastasis, immune responses, angiogenesis, and embryonic morphogenesis. Wound healing is a complex cellular and biochemical process necessary to restore structurally damaged tissue. It involves dynamic interactions and crosstalk between various cell types, interaction with extracellular matrix molecules, and regulated production of soluble mediators and cytokines. In cutaneous wound healing, skin cells migrate from the wound edges into the wound to restore skin integrity...
February 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28105789/pdgfra-amplification-in-multiple-skin-lesions-of-undifferentiated-pleomorphic-sarcoma-ups-a-clue-for-intimal-sarcoma-metastases
#14
A Osio, M-D Vignon-Pennamen, F Pedeutour, C Le Maignan, F Koskas, C Lebbé, A Janin, M Battistella
A 62-year-old HIV-positive man was admitted for multiple cutaneous and subcutaneous nodules on his lower limbs, corresponding to an undifferentiated proliferation of spindle and pleomorphic cells, with irregular nuclei and numerous mitoses. The tumor cells were negative for a large panel of immunohistochemical markers, except CD10. MDM2 immunohistochemical staining was also negative, leading to the diagnosis of FNCLCC grade III Undifferentiated Pleomorphic Sarcoma (UPS). aCGH showed a highly complex karyotype, with amplification of the 4q12 region, an area that contains only the PDGFRa gene...
January 20, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28105349/subcutaneous-metastasis-after-three-surgeries-for-brain-metastasis-from-lung-cancer-a-case-report-and-review-of-the-literature
#15
Ji-Qing Qiu, Yu Cui, Li-Chao Sun, Zhan-Peng Zhu
Lung cancer is a common malignancy that is frequently associated with distant subcutaneous metastasis. However, reports of subcutaneous metastasis of lung cancer after three surgeries for recurrent brain metastasis are scarce. The present study describes the case of a 49-year-old female patient who was admitted to our hospital with a cutaneous mass. The patient had a history of lung cancer and had undergone three surgeries for brain metastases. The subcutaneous mass was considered to be an implantation metastasis from the previous brain metastases...
December 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28100948/malignant-proliferating-trichilemmal-tumour-of-the-scalp-with-intra-cranial-extension-and-lung-metastasis-a-case-report
#16
Lancelot Lobo, Amol Dilip Amonkar, V V S M Kumar Dontamsetty
Malignant proliferating trichilemmal tumour (MPTT) is a rare cutaneous tumour predominantly affecting the scalp, eyelids, neck and face of elderly women. It is a large, solitary, multilobulated lesion that may arise within a pilar cyst. These tumours are largely benign, often cystic and are characterized by trichilemmal keratinisation. However at times, the tumour has an aggressive clinical course and a propensity for distant metastasis. We report a case of a 29-year-old male who presented with a scalp swelling...
December 2016: Indian Journal of Surgery
https://www.readbyqxmd.com/read/28100268/upper-lip-metastasis-of-sarcomatoid-carcinoma-of-the-lung-an-unusual-site-of-disease-a-case-report
#17
Tri Le, Melissa Mayer, Joseph Sailors, David E Gerber, John M Truelson
BACKGROUND: Lip metastases are rare clinical events that are frequently mistaken for other diagnoses. For sarcomatoid lung carcinoma, a rare histologic variant of non-small cell lung cancer, the incidence and pattern of cutaneous spread is poorly understood. CASE PRESENTATION: We present a case of a 79-year-old African American man with a rapidly progressive upper lip cutaneous lesion that provided the first evidence of distant metastatic spread of sarcomatoid lung carcinoma...
January 19, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28096990/extensive-cutaneous-metastases-of-pancreatic-adenocarcinoma-a-case-report-and-review-of-the-literature
#18
Ioannis Kotsantis, Panagiota Economopoulou, Konstantinos Dritsakos, Nikolaos Oikonomopoulos, Marios Bakogeorgos, Cleopatra Rapti, Nikolaos Kentepozidis
Herein, we present the case of a patient with pancreatic cancer and nonumbilical cutaneous metastasis. Patients with pancreatic adenocarcinomas can develop extensive cutaneous metastases involving not only abdominal skin but also other unusual sites such as the scrotum.
January 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28079640/comparison-of-the-american-joint-committee-on-cancer-seventh-edition-and-brigham-and-women-s-hospital-cutaneous-squamous-cell-carcinoma-tumor-staging-in-immunosuppressed-patients
#19
Jessica L Gonzalez, Kiera Cunningham, Rebecca Silverman, Elena Madan, Bichchau M Nguyen
BACKGROUND: The American Joint Committee on Cancer 7th edition (AJCC-7) and Brigham and Women's Hospital (BWH) staging criteria for cutaneous squamous cell carcinoma (cSCC) have not been validated in immunosuppressed patients. OBJECTIVE: To compare the AJCC-7 and BWH staging systems for cSCCs in immunosuppressed patients. METHODS AND MATERIALS: A single-institution retrospective cohort study of cSCCs in immunosuppressed patients. Risks of local recurrence (LR), nodal metastasis (NM), in-transit metastasis, and any poor outcome (PO) were compared among AJCC-7 and BWH tumor T stages...
January 10, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28079637/ln2-cd10-and-ezrin-do-not-distinguish-between-atypical-fibroxanthoma-and-undifferentiated-pleomorphic-sarcoma-or-predict-clinical-outcome
#20
Allison Hanlon, Thomas Stasko, Dan Christiansen, Nika Cyrus, Anjela Galan
BACKGROUND: Atypical fibroxanthoma (AFX) is a rare cutaneous spindled cell neoplasm. For both diagnostic and therapeutic purposes, it is important to distinguish AFX from other poorly differentiated tumors, including undifferentiated pleomorphic sarcoma (UPS). OBJECTIVE: The authors aimed to identify the clinical, histologic, and immunohistochemical expression of LN2, ezrin, and CD10 in AFX and UPS tumors. METHODS AND MATERIALS: The authors retrospectively examined the charts of patients with AFX and UPS treated with Mohs micrographic surgery (MMS) at 2 academic institutions...
January 10, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
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