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(Cutaneous metastasis) -melanoma

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https://www.readbyqxmd.com/read/29150348/de-novo-head-and-neck-cancer-arising-in-solid-organ-transplantation-recipients-the-asan-medical-center-experience
#1
Marn Joon Park, Jong-Lyel Roh, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim, Yoon Se Lee
OBJECTIVE: De novo cancers of head and neck area in solid organ transplantation recipients show standardized incidence ratio (SIR) of 3.8. Immunosuppression following transplantation is suggested to play as a crucial factor in pathogenesis of secondary malignancy. Prognosis of head and neck cancer arising in solid organ transplantation recipients is proven to have poor prognosis. The incidence, risk, prognosis, and survival of de novo malignancy of head and neck area in solid organ transplantation recipients in single-tertiary medical center followed up for 20 years...
November 14, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29145324/a-rare-case-of-merkel-cell-carcinoma-presenting-as-a-giant-intra-thoracic-mass-a-case-report-and-review-of-the-literature
#2
Feng-Wei Kong, Miao Zhang, Heng Wang, Cun-Tao Lu, Wen-Bin Wu, Yuan-Yuan Liu
RATIONALE: Merkel cell carcinoma (MCC) is an aggressive neuroendocrine-derived cutaneous cancer. Ectopic or single metastatic MCC located in thorax is extremely rare; meanwhile, its definite management has not been elucidated yet. PATIENT CONCERNS: A 64-year-old female patient with a giant mass located in her left thorax was presented for stuffy pain of left chest for 6 months and fever for half a month. She underwent radical resection of vulvar MCC 10 years ago...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29136605/scalp-metastasis-as-an-initial-presentation-of-lung-adenocarcinoma-a-case-report-and-literature-review
#3
Veena Gupta, Namita Bhutani, Nisha Marwah, Rajeev Sen
INTRODUCTION: Cutaneous metastasis from primary visceral malignancy is a relatively uncommon clinical entity, with a reported incidence of 0.22%-10% among various series. However, the presence of cutaneous metastasis as the first sign of a clinically silent visceral cancer is exceedingly rare. PRESENTATION OF CASE: We describe here a case of an asymptomatic male patient who presented with a solitary scalp metastasis as the initial manifestation of an underlying lung cancer...
November 10, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29128599/cutaneous-metastasis-of-renal-cell-carcinoma-masquerading-as-an-infected-sebaceous-cyst
#4
Ranil Johann Boaz, Tanush Vig, Amit Jiwan Tirkey, Nirmal Thampi John, Ramani Manoj Kumar, Nitin Kekre
Renal cell carcinoma (RCC) is the third most common genitourinary malignancy with an estimated 1/3(rd) of cases with metastatic disease at the time of diagnosis. Though rare, cutaneous metastasis from RCC is more frequent than any other genitourinary malignancy. Metastasis of RCC to skin carries poor prognosis as coexistent visceral spread is the norm. A 38-year-old man presented one year after radical nephrectomy for clear cell carcinoma of the left kidney with a submental lesion that proved to be metastatic...
November 8, 2017: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29106840/cutaneous-metastasis-in-a-patient-with-lung-cancer
#5
C Martínez-Morán, B Echeverría-García, R Khedaoui, J Borbujo
No abstract text is available yet for this article.
October 26, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29100720/prognostic-factors-for-parotid-metastasis-of-cutaneous-squamous-cell-carcinoma-of-the-head-and-neck
#6
C Bobin, P Ingrand, B Dréno, E Rio, O Malard, F Espitalier
BACKGROUND: Cutaneous squamous cell carcinoma (CSCC) develops on the head in 80% of cases. Parotid metastasis (PM) is rare, but treatment, which associates surgery and radiation therapy, is heavy and prognosis poor. MATERIAL AND METHODS: All cases of parotidectomy for PM of CSCC of the head and neck between 2005 and 2015 were studied retrospectively. Epidemiologic, oncologic and therapeutic data were analyzed. Overall and specific survival were calculated following Kaplan-Meier...
October 31, 2017: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/29078709/subcutaneous-metastasis-from-recurrent-basaloid-squamous-cell-carcinoma-of-the-esophagus
#7
Sonam Puri, Lisa M Holle, Faripour A Forouhar, Jessica M Clement
Background Esophageal cancer is the 11th most common cause of cancer mortality in the United States. It is aggressive in nature and has an ability to spread rapidly through direct extension, lymphatic spread, or hematogenously. With an estimated incidence of 1%, cutaneous metastases from esophageal cancer are extremely rare. Case presentation In this case study and review, we describe a case of recurrent esophageal basaloid squamous cell carcinoma presenting as multiple, rapidly progressing and tender subcutaneous nodules...
January 1, 2017: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/29073717/effective-excision-of-cutaneous-squamous-cell-carcinoma-of-the-face-using-analysis-of-intra-operative-frozen-sections-from-the-whole-specimen
#8
Kor H Hutting, Paul G Bos, Robby E Kibbelaar, Nic J G M Veeger, Klaas W Marck, Chantal M Mouës
BACKGROUND AND OBJECTIVES: We excised cutaneous squamous cell carcinoma (cSCC) of the face while using intra-operative frozen section analysis of the margins in an optimized bread-loafing fashion (WIFSA). METHODS: Medical records were reviewed of 160 cSCCs of the face that were treated by surgical excision with WIFSA between April 2007 and January 2013. The accuracy of WIFSA was verified by comparing results with postoperative formalin-fixed paraffin-embedded (FFPE) sections...
October 26, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29066134/case-report-cutaneous-metastasis-of-lung-carcinoma
#9
Breanne B Jacobs, Stephen Sanders
No abstract text is available yet for this article.
October 21, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29062683/zoster-like-cutaneous-metastatic-adenocarcinoma-of-the-lung-a-case-report
#10
Kumpol Aiempanakit, Siripan Sangmala, Kanokphorn Chiratikarnwong, Sauvarat Auepemkiate
The zosteriform pattern is an infrequent cutaneous finding in oncologic patients who have a skin metastasis from a different primary source. Herein we report a case of adenocarcinoma of the lung which presented with zoster-like lesions along the thoracic dermatome. The histopathology indicated a metastatic neoplasm with variable glandular formations. Immunohistochemistry results pointed to the diagnosis of metastasized lung cancer. We suggest physicians should consider this rare diagnosis when experiencing similar cases...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/29059703/cutaneous-metastasis-as-the-first-presentation-of-hepatocellular-carcinoma
#11
Neil Patel, Gemma Sheehan-Dare, Justin Weir, Suman Verma, Louise Fearfield
No abstract text is available yet for this article.
October 23, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29055623/targeting-of-cell-surface-proteolysis-of-collagen-xvii-impedes-squamous-cell-carcinoma-progression
#12
Célimène Galiger, Stefanie Löffek, Marc P Stemmler, Jasmin K Kroeger, Venugopal R Mittapalli, Lisa Fauth, Philipp R Esser, Johannes S Kern, Frank Meiss, Silke Laßmann, Leena Bruckner-Tuderman, Claus-Werner Franzke
Squamous cell carcinoma (SCC) is one of the most common skin cancers and causes significant morbidity. Although the expression of the epithelial adhesion molecule collagen XVII (ColXVII) has been linked to SCC invasion, only little is known about its mechanistic contribution. Here, we demonstrate that ColXVII expression is essential for SCC cell proliferation and motility. Moreover, it revealed that particularly the post-translational modification of ColXVII by ectodomain shedding is the major driver of SCC progression, because ectodomain-selective immunostaining was mainly localized at the invasive front of human cutaneous SCCs, and exclusive expression of a non-sheddable ColXVII mutant in SCC-25 cells inhibits their matrix-independent growth and invasiveness...
September 27, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29028127/pure-mucinous-colloid-adenocarcinoma-of-the-conjunctiva
#13
Valentina Logunova, Olayemi Sokumbi
Mucinous carcinomas of the periorbital area are very rare malignant tumors and can be primary or secondary to metastasis. Primary mucinous carcinomas of the eyelid include, most commonly, primary cutaneous mucinous carcinoma with endocrine mucin-producing sweat gland carcinoma being a remote second.[1,2,3,4] To our knowledge, primary mucinous carcinomas of conjunctiva or lacrimal gland elements have not been described in the literature.[5,6] Metastatic carcinoma from visceral sites should also be considered in the differential diagnosis...
October 13, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29021425/a-cat-with-suspected-laryngeal-metastasis-with-mucosal-irregularity-resulting-from-apocrine-salivary-gland-adenocarcinoma-in-the-head
#14
Aki Fujiwara-Igarashi, Koichi Shimizu, Masaki Michishita, Yoshihiko Yu, Yuji Hamamoto, Daisuke Hasegawa, Michio Fujita
A 16-year-old castrated male mongrel cat presented with swelling under the left pinna and a 3 -month history of voice change. Laryngeal endoscopy revealed circumferential oedema around the arytenoid cartilages and hypersecretion of saliva. Histopathological examination of the mass around the left ear canal was considered the primary lesion that originated from cutaneous apocrine adenocarcinoma or parotid gland adenocarcinoma, and it metastasized to the larynx, lung and medial retropharyngeal lymph nodes. This report provides new insights into feline laryngeal diseases which could result in laryngeal metastasis with slight mucosal irregularity alone and without obvious radiographic abnormalities...
October 11, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28984696/heterotopic-cutaneous-meningioma-an-unusual-presentation-occurring-in-a-patient-with-a-remote-history-of-intracranial-meningioma
#15
Chibuike Enwereuzo, Luis Moral, Jean M Henneberry
Meningioma is a neoplasm of the meninges, which usually occurs in intracranial sites. Extracranial meningioma has been frequently reported in the sinonasal tract and skull bone, often as extension of intracranial meningiomas. Isolated heterotopic meningioma without contiguous intracranial lesion is extremely rare. A 56-year-old woman presented in December 2015 with 2 firm subcutaneous scalp masses; one in the left lateral (temporal) and the other in the left superior (parietal) region. The clinical impression was that of lipoma...
September 28, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28980225/merkel-cell-carcinoma-of-the-buccal-mucosa-and-lower-lip
#16
Mohammed N Islam, Hardeep Chehal, Molly Housley Smith, Sarah Islam, Indraneel Bhattacharyya
Merkel cell carcinoma (MCC) is an uncommon relatively aggressive neuroendocrine dermal neoplasm first described in 1972 as a tumor of the sun exposed skin. Although most MCC affect the skin of the head and neck, rare primarily oral mucosal cases have been documented. Merkel cells are nondendritic neuroendocrine cells that are found not only in the skin but also the oral mucosa and give rise to MCC. Neuroendocrine cells may be found as aggregates in organs or as diffuse or isolated cells within organs and their epithelial lining...
October 4, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28969748/primary-merkel-cell-carcinoma-on-the-cheek-three-case-reports
#17
Tao Fan, Ying Jie Song, Xiu Li Liu, Jun Zhou, Hong Yang, Ya Nan Wei, Chao Qi Wang
Merkel cell carcinoma (MCC) is a rare aggressive cutaneous neuroendocrine carcinoma that typically arises in sunexposed areas of the skin. Herein, we present three cases of primary MCC of the cheek. Case 1 had multiple nodules and mild swelling on the left cheek and eyelids, the patient did not receive any treatment and died after 10 months. Case 2 presented with nodule on patient's left cheek, which increased gradually. The patient was treated with surgical resection from the tumor edge 0.3 cm and skin flap transplantation, she died after 21 months...
September 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28960456/primary-large-cell-neuroendocrine-carcinoma-of-the-skin-an-under-recognized-entity-and-a-mimic-of-metastatic-disease
#18
Ian Marie Lano, Daniel Rayson, Thomas Arnason, Noreen M G Walsh
Primary large cell neuroendocrine carcinomas of the skin are exceptionally rare and can be diagnosed only when a metastasis from another organ has been excluded. We report the case of a 62 year old woman with a cutaneous papule on the mid-chest which generated a differential diagnosis of vascular lesion and basal cell carcinoma. Following excision, microscopic evaluation revealed a dermal large cell undifferentiated carcinoma, with a brisk mitotic rate and focal geographic necrosis. Mucin production was absent...
September 28, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28951515/merkel-cell-carcinoma-cardiac-metastasis-causing-cardiac-tamponade
#19
Murray Di Loreto, Roslyn Francis
We describe an unusual presentation of Merkel cell carcinoma (MCC), a rare neuroendocrine cutaneous tumour. A 59-year-old man presented with a 2-week history of dyspnoea on a background of MCC of the left elbow that was diagnosed after an axillary lymph node metastasis had appeared. He was clinically diagnosed with cardiac tamponade and received urgent pericardiocentesis. Thoracic CT imaging revealed a large infiltrating mass within the inferior aspect of the heart, confirmed to be MCC via immunohistochemistry of the pericardial fluid...
September 25, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28937781/-lymph-node-metastasis-of-merkel-cell-carcinoma-without-known-cutaneous-primary-case-report
#20
Arpád Szabó, Igor Richter, Dana Frydrychová, Martina Saláková, Tomáš Jirásek
Merkel cell carcinoma is a rare cutaneous tumor with an aggressive clinical course. In most cases it is associated with Merkel cell polyomavirus infection. Exceptionally, the tumor can present as a lymph node metastasis without a discernible cutaneous primary. In this report we present the case of a 42 year-old man with inguinal lymphadenopathy, histologically consistent with Merkel cell carcinoma. Tumor cells expressed immunohistochemically chromogranin-A, synaptophysin and displayed dot-like positivity for cytokeratin 20...
2017: Ceskoslovenská Patologie
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