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Function pulmonary

I Papachatzakis, L Velentza, P Zarogoulidis, A Kallianos, G Trakada
OBJECTIVE: Chronic Obstructive Pulmonary Disease (COPD) and Obstructive Sleep Apnea (OSA) are separately associated with several comorbidities. The coexistence of the two diseases, referred to as overlap syndrome, may act as a predisposing factor for a higher prevalence of comorbidities compared to those associated with each disease separately. The objective of the study was to evaluate the relative prevalence of cardiovascular as well as other comorbidities, in patients with the overlap syndrome, as compared to patients that are diagnosed solely with OSA...
July 2018: European Review for Medical and Pharmacological Sciences
Ryan J Good, Laura Hernandez-Lagunas, Ayed Allawzi, Joanne K Maltzahn, Christine U Vohwinkel, Arun K Upadhyay, Uday Kompella, Konstantin G Birukov, Todd C Carpenter, Carmen C Sucharov, Eva Nozik-Grayck
MicroRNAs (miRNAs) are non-coding RNAs that regulate gene expression in many diseases, though the contribution of miRNAs to the pathophysiology of lung injury remains obscure. We hypothesized that dysregulation of miRNA expression drives the changes in key genes implicated in the development of lung injury. To test our hypothesis, we utilized a model of lung injury induced early after administration of intratracheal bleomycin (0.1 U). Wild-type mice were treated with bleomycin or PBS and lungs were collected at 4 or 7 days...
July 19, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
Yang Liu, Wen-Bin Dong
With the increase in the rescue success rate of critically ill preterm infants and extremely preterm infants, the incidence rate of bronchopulmonary dysplasia (BPD) is increasing year by year. BPD has a high mortality rate and high possibility of sequelae, which greatly affects the quality of life of preterm infants and brings a heavy burden to their families, and so the treatment of BPD is of vital importance. At present, no consensus has been reached on the treatment measures for BPD. However, recent studies have shown that early application of caffeine can prevent BPD...
July 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
Lindsey Eldridge, Elizabeth M Wagner
Both systemic (tracheal and bronchial) and pulmonary circulations perfuse the lung. However, documentation of angiogenesis of either is complicated by the presence of the other. Well-documented angiogenesis of the systemic circulations have been identified in asthma, cystic fibrosis, chronic thromboembolism, and primary carcinomas. Angiogenesis of the vasa vasorum, which are branches of bronchial arteries, is seen in the walls of large pulmonary vessels after a period of chronic hypoxia. Documentation of increased pulmonary capillaries has been shown in models of chronic hypoxia, after pneumonectomy, and in some carcinomas...
July 18, 2018: Journal of Physiology
Hatice Esra Cetkin, Arzu Tuna
In this study, it was aimed to determine how the postoperative pain level, state-trait anxiety level, and respiratory function were affected by the health education given through a patient education booklet to patients with lung cancer, in comparison with control group, before pulmonary resection through thoracotomy. The 60 patients (n = 60) having pulmonary resection indication because of lung cancer were recruited in the present study. The patients were separated as control (n = 30) and experimental groups (n = 30)...
July 18, 2018: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
Xia Meng, Xinrong Sun, Yonghong Zhang, Hongyang Shi, Wenjing Deng, Yanqin Liu, Guizuo Wang, Ping Fang, Shuanying Yang
Peroxisome proliferator-activated receptor-γ (PPARγ) agonist pioglitazone (PGZ) exhibits potential protective effects in asthma. Recently, regulator of G protein 4 (RGS4) has been reported to be associated with immunological and inflammatory responses. However, no evidence has shown the influence of PPARγ on RGS4 expression in airway disorders. In this study, BALB/c mice received ovalbumin (OVA) sensitization followed by OVA intranasal challenge for 90 days to establish a chronic asthma mouse model. Accompanied with OVA challenge, the mice received administration of PPARγ agonist PGZ (10 mg/kg) intragastrically or RGS4 inhibitor CCG 63802 (0...
July 19, 2018: Inflammation
Kim Han, An Nguyen, Javier Traba, Xianglan Yao, Maryann Kaler, Rebecca D Huffstutler, Stewart J Levine, Michael N Sack
A fasting mimetic diet blunts inflammation, and intermittent fasting has shown ameliorative effects in obese asthmatics. To examine whether canonical inflammatory pathways linked with asthma are modulated by fasting, we designed a pilot study in mild asthmatic subjects to assess the effect of fasting on the NLRP3 inflammasome, Th2 cell activation, and airway epithelial cell cytokine production. Subjects with documented reversible airway obstruction and stable mild asthma were recruited into this study in which pulmonary function testing (PFT) and PBMCextraction was performed 24 h after fasting, with repeated PFT testing and blood draw 2...
July 18, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
Christopher David Swan, Thomas Gottlieb
We report a case of Cryptococcus neoformans pulmonary infection complicated by empyema in a 79-year-old man with diffuse large B-cell lymphoma treated with R-CHOP and ibrutinib. A literature review identified 25 cases of cryptococcal pleural disease published since 1980. Most cases were caused by the C. neoformans species in immunocompromised hosts with an exudative pleural effusion and lymphocyte-predominant infiltrate. The cryptococcal antigen test was often positive when pleural fluid and serum were tested...
July 18, 2018: BMJ Case Reports
Massimo Nabissi, Oliviero Marinelli, Maria Beatrice Morelli, Giovanna Nicotra, Romilde Iannarelli, Consuelo Amantini, Giorgio Santoni, Filippo Maggi
Chronic obstructive pulmonary disease (COPD) is a respiratory disorder characterized by a progressive and irreversible airflow limitation. COPD is associated to a chronic inflammatory response with infiltration of inflammatory cells in the surface epithelium of large airways and abnormalities in structure and functions of cilia. Thyme (Thymus vulgaris L.) is a traditional medicinal plant of the Mediterranean area used to treat respiratory disorders. We previously evidenced that thyme extract reduce IL-1beta and IL-8, by downregulating the activated NF-κB levels, suggesting its potential therapeutically use in COPD...
September 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Nurul Hannim Zaidun, Zar Chi Thent, Azian Abd Latiff
The incidence of diseases related to oxidative stress disorders have been increased dramatically. Alternatives medicine or the active compound extracted from the natural products received great attention among researches at the present era. Naringenin (NG), a common dietary flavanone, found in the citrus fruits such as oranges, bergamots, lemons and grapefruit. It is used in the several oxidative stress disorders as the nutraceutical value of the compound emerges. Functionally, the antioxidants effect of NG is primarily attributed by reducing the free radical like reactive oxygen species (ROS) and enhancing the antioxidants activity such as superoxide dismutase (SOD), catalase, glutathione (GSH) in chronic diseases such as cardiovascular, neurodegenerative, diabetes, pulmonary, cancer and nephropathy...
July 15, 2018: Life Sciences
Ryan G Short, Tina D Tailor
History A 31-year-old woman with a history of bilateral orthotopic lung transplantation performed 10 months earlier for cystic fibrosis presented for a routine follow-up appointment, with her chief symptom being a cough. The cough started approximately 1 month prior to this appointment and was minimally productive of clear to yellow phlegm. In addition to her cough, she reported increased sinus congestion and a sensation of "something in her upper chest." She denied shortness of breath, wheezing, hemoptysis, or cigarette smoking...
August 2018: Radiology
Chunhua Guo, Min Lei, Yong Wang, Limei Hua, Sujuan Xue, Dan Yu, Chunhua Zhang, Dawei Wang
Considerate proportion of elderly patients with a rib fracture is susceptible to pulmonary complications, especially pneumonia. We aimed to assess the effect of oral administration of the probiotic Lactobacillus casei Shirota (LcS) on pneumonia and pulmonary functions among elderly patients with single rib fracture. The current study including 204 eligible elderly patients with a single rib fracture was conducted. Patients were randomly assigned to receive oral administration of skimmed milk containing either a commercial probiotic LcS or placebo daily for 1 mo after the fracture, followed by pneumonia assessments, pulmonary function testing including forced expiratory volume (FEV), negative inspiratory pressure (NIP), and forced vital capacity (FVC), as well as evaluation of potential adverse effects including myocardial infarction, acute kidney injury, nonunion of fractured bone, or stroke...
July 18, 2018: Journal of Food Science
Cardine Martins Dos Reis, Manuela Karloh, Fernanda Rodrigues Fonseca, Roberta Rodolfo Mazzali Biscaro, Giovana Zarpellon Mazo, Anamaria Fleig Mayer
OBJECTIVE: To develop reference equations for the Glittre Activities of Daily Living test (Glittre ADL-test) on the basis of anthropometric and demographic variables in apparently healthy individuals. A secondary objective was to determine the reliability of the equations in a sample of COPD patients. METHODS: This was a cross-sectional study including 190 apparently healthy individuals (95 males; median age, 54.5 years [range, 42-65]; median FEV1 = 97% [range, 91-105...
July 16, 2018: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
Dorina Esendağlı, Sevinç Sarınç Ulaşlı, Antonio Esquinas
Humidification therapy is widely used in patients during invasive ventilation and the importance of heating and humidifying the inhaled air is well defined in both the acute and long term setting. On the other hand the continuous usage of humidification in noninvasive ventilation is controversial and the long term effects are still not well defined. The usage of noninvasive ventilation is especially important in hypercapnic Chronic obstructive pulmonary disease (COPD) and also the obstructive sleep apnea syndrome (OSAS) patients and compliance to this treatment is essential in long term...
March 2018: Tüberküloz Ve Toraks
İpek Candemir, Pınar Ergün, Dicle Kaymaz, Filiz Taşdemir, Fatma Şengül, Nurcan Egesel
Introduction: Oral nutritional supplement (ONS), an important part of multidisciplinary pulmonary rehabilitation (PR) program, is indicated according to body composition abnormalities in the patients with chronic obtructive pulmonary disease (COPD). We evaluated efficacy of oral nutritional supplement (ONS) during 5-8 months in patients with COPD who completed PR program. Materials and Methods: The data of 41 patients with stable COPD were recorded after the approval had been taken...
March 2018: Tüberküloz Ve Toraks
Thomas L Ratchford, Jeffrey H Teckman, Dhiren R Patel
Cystic fibrosis (CF) is a severe, progressive, multi-systemic disease that is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Optimizing nutrition is critical, as higher growth parameters are associated with better pulmonary function and outcomes, but unfortunately patients with this disease are prone to malnutrition, growth failure, and vitamin deficiencies. The purpose of this review is to provide a timely highlight of the physiologic processes and outcome data to support today's management strategies, as well as review these principles themselves...
July 18, 2018: Expert Review of Gastroenterology & Hepatology
Stefan M Frent, Kenneth R Chapman, Michael Larbig, Alexander Mackay, Robert Fogel, Florian S Gutzwiller, Steven Shen, Francesco Patalano, Donald Banerji, Konstantinos Kostikas, Jadwiga A Wedzicha
RATIONALE: Chronic obstructive pulmonary disease (COPD) exacerbations accelerate lung function decline, reduce quality of life, and increase mortality. A subset of patients (n=457) from the FLAME study used the EXAcerbations of COPD Tool (EXACT®) to capture symptom-defined exacerbations. OBJECTIVES: To evaluate the effect of indacaterol/glycopyrronium (IND/GLY) versus salmeterol/fluticasone (SFC) on symptom-defined exacerbations measured using EXACT, and to assess differences between these events and exacerbations requiring healthcare resource use (HCRU)...
July 18, 2018: American Journal of Respiratory and Critical Care Medicine
Robin Vos, Wim A Wuyts, Olivier Gheysens, Karolien E Goffin, Veronique Schaevers, Stijn E Verleden, Anke Van Herck, Annelore Sacreas, Tobias Heigl, John E McDonough, Jonas Yserbyt, L Godinas, Lieven J Dupont, Arne P Neyrinck, Dirk E Van Raemdonck, Eric K Verbeken, Bart M Vanaudenaerde, Geert M Verleden
Pirfenidone may attenuate the decline of pulmonary function in restrictive allograft syndrome (RAS) after lung transplantation. We retrospectively assessed all lung transplant recipients with RAS who were treated with pirfenidone for at least 3 months (n=11) in our lung transplant center and report on their long-term outcomes following initiation of pirfenidone. Main outcome parameters included evolution of pulmonary function and overall survival. Pirfenidone appears to attenuate the decline in FVC and FEV1 ...
July 18, 2018: American Journal of Transplantation
Jeffrey T White, Kunj R Sheth, Aylin E Bilgutay, David R Roth, Paul F Austin, Edmond T Gonzales, Nicolette K Janzen, Duong D Tu, Angela G Mittal, Chester J Koh, Sheila L Ryan, Carolina Jorgez, Abhishek Seth
Objective: Review outcomes of Prune Belly Syndrome (PBS) with the hypothesis that contemporary management improves mortality. Methods: A retrospective chart review of inpatient and outpatient PBS patients referred between 2000 and 2018 was conducted to assess outcomes at our institution. Data collected included age at diagnosis, concomitant medical conditions, imaging, operative management, length of follow-up, and renal function. Results: Forty-five PBS patients presented during these 18 years. Prenatal diagnoses were made in 17 (39%); 65% of these patients underwent prenatal intervention...
2018: Frontiers in Pediatrics
Brith Andresen, Gaute Døhlen, Lien My Diep, Harald Lindberg, Erik Fosse, Marit Helen Andersen
Objective: This prospective non-randomised study was performed to compare the psychosocial function and clinical outcomes following surgical and percutaneous implantation of a pulmonary valve at 3 months and 1 year after treatment. Methods: All patients were consecutively admitted for treatment by either method from June 2011 to October 2014. The data of 20 patients treated with the percutaneous technique and 14 patients treated with open heart surgery were compared...
2018: Open Heart
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