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https://www.readbyqxmd.com/read/28926468/rituximab-experience-in-patients-with-long-standing-systemic-sclerosis-associated-interstitial-lung-disease-a-series-of-14-patients
#1
Alper Sari, Denizcan Guven, Berkan Armagan, Abdulsamet Erden, Umut Kalyoncu, Omer Karadag, Sule Apras Bilgen, Ihsan Ertenli, Sedat Kiraz, Ali Akdogan
OBJECTIVES: The objective of this study was to report the experience with rituximab treatment in a case series of patients with long-standing systemic sclerosis-associated interstitial lung disease (SSc-ILD). METHODS: We reviewed the charts of 197 SSc patients. Fourteen patients who received rituximab for SSc-ILD participated in this analysis. Pulmonary function tests, high-resolution thorax computed tomography and modified Rodnan skin scores were evaluated at baseline and end of the follow-up...
September 19, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28926132/prenatal-diagnosis-of-total-and-partial-anomalous-pulmonary-venous-connection-multicentre-cohort-study-and-meta-analysis
#2
REVIEW
Dario Paladini, Angela Pistorio, L H Wu, Gabriella Meccariello, Ting Lei, Giulia Tuo, Gloria Donarini, Maurizio Marasini, Hong-Ning Xie
OBJECTIVES: Aim of this study is to describe the sonographic features and associations of Total and Partial Anomalous Pulmonary Venous Connection (TAPVC, PAPVC) and scimitar syndrome (SS) and to review the relevant literature systematically in order to underline the associations and the sonographic features more frequently associated with these conditions. METHODOLOGY: Retrospective cohort study. Assessed variables include: TAPVC subtype, gestational age at diagnosis, area behind LA, ventricular disproportion, vertical vein, pulmonary venous obstruction, mode of diagnosis, association with cardiac and extra-cardiac conditions, pregnancy and feto-neonatal outcome...
September 19, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28925009/efficacy-of-patients-preferred-exercise-modalities-in-chronic-obstructive-pulmonary-disease-a-parallel-group-randomized-clinical-trial
#3
Meng Wu, Lu-Qian Zhou, Shi Li, Su Zhao, Hui-Jun Fan, Jie-Min Sun, Xiao-Nan Li, Jian Luo, An-Qi Wang, Jian-Ping Wu, Xiaoying Li, Jin-Nong Zhang
INTRODUCTION: Physical exercise effectively improves health-related quality of life in patients with chronic obstructive pulmonary disease (COPD). However, application of this medical intervention is problematic, due to poor adherence to the exercise program or unawareness of the significance of this intervention. OBJECTIVE: To determine whether COPD patients who adopted personal-preferred exercise modalities (PPEMs) for daily training would demonstrate sustained benefits due to improved adherence...
September 19, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28924387/activation-of-nrf2-attenuates-pulmonary-vascular-remodeling-via-inhibiting-endothelial-to-mesenchymal-transition-an-insight-from-a-plant-polyphenol
#4
Yucai Chen, Tianyi Yuan, Huifang Zhang, Yu Yan, Danshu Wang, Lianhua Fang, Yang Lu, Guanhua Du
The endothelial-to-mesenchymal transition (EndMT) has been demonstrated to be involved in pulmonary vascular remodeling. It is partly attributed to oxidative and inflammatory stresses in endothelial cells. In current study, we conducted a series of experiments to clarify the effect of salvianolic acid A (SAA), a kind of polyphenol compound, in the process of EndMT in human pulmonary arterial endothelial cells and in vivo therapeutic efficacy on vascular remodeling in monocrotaline (MCT)-induced EndMT. EndMT was induced by TGFβ1 in human pulmonary arterial endothelial cells (HPAECs)...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28924315/comparison-between-continuous-thoracic-epidural-block-and-continuous-thoracic-paravertebral-block-in-the-management-of-thoracic-trauma
#5
Shalendra Singh, Mathews Jacob, S Hasnain, Mathangi Krishnakumar
BACKGROUND: Postoperative pain is thought to be the single most important factor leading to ineffective ventilation and impaired secretion clearance after thoracic trauma. Effective pain relief can be provided by thoracic epidural analgesia but may have side effects or contraindications. Paravertebral block is an effective alternative method without the side effects of a thoracic epidural. We did this study to compare efficacy of thoracic epidural and paravertebral block in providing analgesia to thoracic trauma patients...
April 2017: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/28924268/predictors-of-pulmonary-function-test-values-for-pakistani-children-aged-5-14-years
#6
Muhammad Asif, Ghulam Mustafa, Muhammad Aslam, Saima Altaf
OBJECTIVE: To predict pulmonary function test values in children. METHODS: This cross-sectional study was carried out at Nishtar Medical College, Multan, Pakistan, from August 2014 to March 2015, and comprised school-going children aged 5-14 years. After noting their gender, age, height and weight, the pulmonary function test measures, force vital capacity, forced expiratory volume in 1 second and peak expiratory flow rate were taken. Simple and multiple regression models were used for the prediction of pulmonary function test values...
September 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28924136/a-case-of-tracheobronchomalacia-mimicking-acute-pulmonary-embolism
#7
Stefani M Schwartz, Katherine J Greco, Venugopal Reddy
BACKGROUND Pulmonary embolism is a common acute postoperative complication and is associated with 100,000 deaths per year in the USA. Tracheobronchomalacia is an uncommon condition, which presents with similar symptoms to pulmonary embolism, including hypoxemia, tachycardia, and shortness of breath. We describe a case of a patient who presented with postoperative pulmonary symptoms that were initially thought to be due to pulmonary embolism. However, following imaging investigations these symptoms were found to be due to tracheobronchomalacia...
September 19, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28924113/the-evaluation-of-interstitial-abnormalities-in-group-b-of-the-2011-global-initiative-for-chronic-obstructive-lung-disease-gold-classification-of-chronic-obstructive-pulmonary-disease-copd
#8
Masahiro Ohgiya, Hirotoshi Matsui, Atsuhisa Tamura, Takafumi Kato, Shinobu Akagawa, Ken Ohta
Objective In 2011, the Global Initiative for Chronic Obstructive Lung Disease (GOLD) classification categorized chronic obstructive pulmonary disease (COPD) patients into 4 groups. A report demonstrated that the mortality in Group B was higher than that in Group C. Ischemic heart disease and cancer were suggested to be the cause. The aim of the present study was to test the hypothesis that interstitial lung abnormalities (ILAs) are more prevalent in Group B than Group C and that they may be responsible for the higher mortality in Group B...
September 15, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28923559/the-independent-effect-of-cancer-on-outcomes-a-potential-limitation-of-surgical-risk-prediction
#9
Ira L Leeds, Joseph K Canner, Jonathan E Efron, Nita Ahuja, Elliott R Haut, Elizabeth C Wick, Fabian M Johnston
BACKGROUND: Cancer patients are often thought to have worse surgical outcomes. There is a growing view that risk models do not adequately predict these outcomes. This study aims to compare the use of common risk models for benign versus malignant gastrointestinal disease. MATERIALS AND METHODS: The National Surgical Quality Improvement Program (NSQIP) 2005-2015 participant use files were queried for patients undergoing elective surgery for benign and malignant diseases with a primary procedure code for major colon, pancreas, or stomach resection...
September 15, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28923146/cannon-ball-diagnosis-and-management-in-a-flight-attendant-candidate
#10
Meryem Zerrik, Houda Echchachoui, Zakaria Iloughmane, Choukri El'mhadi, Salaheddine Elkhader, Laila Benaissa, Mohamed Chemsi
BACKGROUND: ''Cannon ball'' opacities on chest X-rays are a common manifestation of hematogenous dissemination of a malignant tumor in the lungs. They indicate an advanced stage of disease with a very grim prognosis in terms of cure and survival. In aerospace medicine, this aspect means the patient is unfit for flight duties. Nonmetastatic etiologies of pulmonary nodules are rare. We report a case of cannon ball opacities discovered fortuitously during an admission visit. CASE REPORT: A 23-yr-old flight attendant candidate came to the Aeromedical Expertise Center of the Military Hospital in Rabat for medical evaluation...
October 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28923145/pulmonary-effects-from-a-simulated-long-duration-mission-in-a-confined-cockpit
#11
Jeremy Beer, Todd S Dart, Joseph Fischer, James Kisner
INTRODUCTION: A recent U-2 fatigue study, in which 10 subjects completed 2 simulated long-duration missions breathing either 100% oxygen or air in a hypobaric chamber, offered an opportunity to compare subjects' pulmonary function before and after remaining seated in a confined cockpit for 12 h. METHODS: In one U-2 mission configuration, the subject wore a full pressure suit and breathed aviator's breathing oxygen while chamber pressure was maintained at 4572 m (15,000 ft) above mean sea level...
October 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28923049/roflumilast-reverses-cftr-mediated-ion-transport-dysfunction-in-cigarette-smoke-exposed-mice
#12
S Vamsee Raju, Lawrence Rasmussen, Peter A Sloane, Li Ping Tang, Emily Falk Libby, Steven M Rowe
BACKGROUND: Dysfunction in cystic fibrosis transmembrane conductance regulator (CFTR) can be elicited by cigarette smoke and is observed in patients with chronic bronchitis. We have previously demonstrated in human airway epithelial cell monolayers that roflumilast, a clinically approved phosphodiesterase 4 inhibitor that reduces the risk of exacerbations in chronic obstructive pulmonary disease patients with chronic bronchitis and a history of exacerbations, activates CFTR-dependent chloride secretion via a cAMP-mediated pathway, partially restores the detrimental effects of cigarette smoke on CFTR-mediated ion transport, and increases CFTR-dependent gastrointestinal fluid secretion in isolated murine intestine segments...
September 18, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28922978/6-year-old-sheep-as-a-clinically-relevant-large-animal-model-for-aortic-valve-replacement-using-tissue-engineered-grafts-based-on-decellularized-allogenic-matrix
#13
Karolina Theodoridis, Igor Tudorache, Serghei Cebotari, Tanja Meyer, Alexandru Calistru, Samir Sarikouch, Cristoph Bara, Axel Haverich, Andres Hilfiker
Tissue-engineered (TE) grafts based on decellularized grafts have shown very promising results in preclinical and clinical studies. However, in animal models valves have either been tested in juvenile models or in the clinically less relevant pulmonary valve position. In this study, we tested the grafts in the aortic valve (AV) position of 6-year old sheep, as geriatric patients in need of an aortic valve substitute due to calcification are the largest patient group benefiting from TE grafts. Decellularized AV (n=4) and decellularized AV additionally re-endothelialized with autologous cells (n=3) were implanted in the aortic valve position of 6-year-old female sheep...
September 19, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28922692/phosphodiesterase-4-inhibitors-for-chronic-obstructive-pulmonary-disease
#14
REVIEW
Jimmy Chong, Bonnie Leung, Phillippa Poole
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is associated with cough, sputum production or dyspnoea and a reduction in lung function, quality of life and life expectancy. Apart from smoking cessation, there are no other treatments that slow lung function decline. Roflumilast and cilomilast are oral phosphodiesterase 4 (PDE4) inhibitors proposed to reduce the airway inflammation and bronchoconstriction seen in COPD. This is an update of a Cochrane review first published in 2011 and updated in 2013...
September 19, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28922375/elevated-igg4-serum-levels-in-patients-with-cystic-fibrosis
#15
Axelle Clerc, Quitterie Reynaud, Stéphane Durupt, Colette Chapuis-Cellier, Raphaële Nové-Josserand, Isabelle Durieu, Jean Christophe Lega
OBJECTIVE: Serum immunoglobulin (Ig) G4 elevation has been associated with several pathological conditions other than IgG4-related disease (IgG4-RD). In cystic fibrosis (CF), an elevation of specific IgG4 has been associated with colonization and infection by Pseudomonas aeruginosa. IgG4 elevation may be a marker of chronic infection or inflammatory stimulation. The aim of this study was to explore the prevalence of elevated IgG4 levels in CF and its correlation with the major clinical and microbiological features found in CF patients...
2017: PloS One
https://www.readbyqxmd.com/read/28921399/artesunate-inhibits-renal-ischemia-reperfusion-stimulated-lung-inflammation-in-rats-by-activating-ho-1-pathway
#16
Zhaohui Liu, Junjie Zhang, Shitong Li, Jihong Jiang
Artesunate (AS), a semi-synthetic derivative of Artemisia, has been shown to exert a wide range of pharmacological effects, such as anti-inflammatory and antioxidant functions. However, the protective functions of AS on renal ischemia reperfusion injury (RIR)-stimulated lung inflammation remain unclear. In this research, acute lung injury (ALI) was stimulated by renal ischemia reperfusion injury (RIR). AS (15 mg/kg) was intraperitoneal administrated to rat 1 h before RIR stimulation. Serum and pulmonary NO, MDA, IL-6, MIP-2, and PGE2 levels, arterial blood gas and biochemistry, lung wet/dry weight ratio and MPO activity, total cell number and protein concentration in BALF, tissue histology, and NF-κB expression were determined...
September 18, 2017: Inflammation
https://www.readbyqxmd.com/read/28921174/bilateral-segmentectomies-using-virtual-assisted-lung-mapping-val-map-for-metastatic-lung-tumors
#17
Keita Nakao, Masaaki Sato, Jun-Ichi Nitadori, Jun Nakajima
BACKGROUND: Virtual-assisted lung mapping (VAL-MAP) has been used not only in wedge resection but also in segmentectomy for hardly palpable lung nodules. We herein report a case of bilateral segmentectomy using VAL-MAP with chronological change of pulmonary function test results. CASE PRESENTATION: A 50-year-old female was found to have a colorectal cancer with pulmonary nodules in both sides of the lungs considered as synchronous lung metastases. After sigmoidectomy for primary cancer and chemotherapy, treatments for small nodules in both sides of the lungs were planned...
September 18, 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28920925/expression-of-piwi-protein-miwi2-defines-a-distinct-population-of-multiciliated-cells
#18
Gregory A Wasserman, Aleksander D Szymaniak, Anne C Hinds, Kazuko Yamamoto, Hirofumi Kamata, Nicole Ms Smith, Kristie L Hilliard, Claudia Carrieri, Adam T Labadorf, Lee J Quinton, Xingbin Ai, Xaralabos Varelas, Felicia Chen, Joseph P Mizgerd, Alan Fine, Dónal O'Carroll, Matthew R Jones
P-element-induced wimpy testes (Piwi) proteins are known for suppressing retrotransposon activation in the mammalian germline. However, whether Piwi protein or Piwi-dependent functions occur in the mammalian soma is unclear. Contrary to germline-restricted expression, we observed that Piwi-like Miwi2 mRNA is indeed expressed in epithelial cells of the lung in adult mice and that it is induced during pneumonia. Further investigation revealed that MIWI2 protein localized to the cytoplasm of a discrete population of multiciliated airway epithelial cells...
September 18, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28919734/usefulness-of-the-desaturation-distance-ratio-from-the-six-minute-walk-test-for-patients-with-copd
#19
Yukari Fujimoto, Yutaro Oki, Masahiro Kaneko, Hideki Sakai, Shogo Misu, Takumi Yamaguchi, Yuji Mitani, Hisafumi Yasuda, Akira Ishikawa
PURPOSE: A straightforward, noninvasive method is needed to assess emphysema and pulmonary hypertension (PH) in COPD patients. The desaturation-distance ratio (DDR) is an index derived from the distance traveled and level of desaturation during a six-minute walk test (6MWT); it has previously been shown to be associated with percentage of forced expiratory volume in the first second of expiration (%FEV1.0) and percentage of diffusion capacity of the lung for carbon monoxide (%DLCO). The aim of this study was to examine the associations between DDR and emphysema and PH...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28919733/cycle-ergometer-and-inspiratory-muscle-training-offer-modest-benefit-compared-with-cycle-ergometer-alone-a-comprehensive-assessment-in-stable-copd-patients
#20
Kai Wang, Guang-Qiao Zeng, Rui Li, Yu-Wen Luo, Mei Wang, Yu-He Hu, Wen-Hui Xu, Lu-Qian Zhou, Rong-Chang Chen, Xin Chen
BACKGROUND: Cycle ergometer training (CET) has been shown to improve exercise performance of the quadriceps muscles in patients with COPD, and inspiratory muscle training (IMT) may improve the pressure-generating capacity of the inspiratory muscles. However, the effects of combined CET and IMT remain unclear and there is a lack of comprehensive assessment. MATERIALS AND METHODS: Eighty-one patients with COPD were randomly allocated to three groups: 28 received 8 weeks of CET + IMT (combined training group), 27 received 8 weeks of CET alone (CET group), and 26 only received 8 weeks of free walking (control group)...
2017: International Journal of Chronic Obstructive Pulmonary Disease
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