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Hyperthyroidism

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https://www.readbyqxmd.com/read/28534147/hypothyroidism-in-hospitalized-elderly-patients-a-sign-of-worse-prognosis
#1
N Sforza, J Rosenfarb, R Rujelman, M Rosmarin, E Blanc, C Frigerio, P Fossati, D Caruso, C Faingold, T Meroño, G Brenta
PURPOSE: Overt hypothyroidism has adverse clinical consequences and might worsen prognosis in critically ill elderly patients. However, the difficult interpretation of thyroid function tests (TFT) due to non-thyroidal illness (NTI) has led to discouragement of screening for thyroid dysfunction. Our aim was to determine the prevalence of TFT compatible with hypothyroidism and to study its influence on mortality among hospitalized elderly patients. METHODS: In this prospective study we consecutively included all patients ≥60 years admitted by the Internal Medicine Department to the hospital ward (n = 451) of the Cesar Milstein Hospital in Buenos Aires, Argentina...
May 22, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28529524/antithyroid-drug-therapy-for-graves-disease-and-implications-for-recurrence
#2
REVIEW
Jia Liu, Jing Fu, Yuan Xu, Guang Wang
Graves' disease (GD) is the most common cause of hyperthyroidism worldwide. Current therapeutic options for GD include antithyroid drugs (ATD), radioactive iodine, and thyroidectomy. ATD treatment is generally well accepted by patients and clinicians due to some advantages including normalizing thyroid function in a short time, hardly causing hypothyroidism, and ameliorating immune disorder while avoiding radiation exposure and invasive procedures. However, the relatively high recurrence rate is a major concern for ATD treatment, which is associated with multiple influencing factors like clinical characteristics, treatment strategies, and genetic and environmental factors...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28527122/effects-of-cigarette-smoke-exposure-during-suckling-on-food-intake-fat-mass-hormones-and-biochemical-profile-of-young-and-adult-female-rats
#3
Patricia Cristina Lisboa, Patricia Novaes Soares, Thamara Cherem Peixoto, Janaine Cavalcanti Carvalho, Camila Calvino, Vanessa Silva Tavares Rodrigues, Dayse Nascimento Bernardino, Viviane Younes-Rapozo, Alex Christian Manhães, Elaine de Oliveira, Egberto Gaspar de Moura
PURPOSE: Children from smoking mothers have a higher risk of developing obesity and associated comorbidities later in life. Different experimental models have been used to assess the mechanisms involved with this increased risk. Using a rat model of neonatal nicotine exposure via implantation of osmotic minipumps in lactating dams, we have previously shown marked sexual dimorphisms regarding metabolic and endocrine outcomes in the adult progeny. Considering that more than four thousand substances are found in tobacco smoke besides nicotine, we then studied a rat model of neonatal tobacco smoke exposure: adult male offspring had hyperphagia, obesity, hyperglycemia, hypertriglyceridemia, secondary hyperthyroidism and lower adrenal hormones...
May 19, 2017: Endocrine
https://www.readbyqxmd.com/read/28525971/left-ventricular-mural-thrombus-and-dual-coronary-embolization-associated-with-hyperthyroid-cardiomyopathy-and-atrial-fibrillation-a-case-report
#4
Guohui Liu, Ping Yang, Yuquan He
BACKGROUND: The majority of acute myocardial infarction (AMI) events are caused by thrombotic occlusion of the coronary artery, secondary to atherosclerotic plaque erosion or rupture. However, coronary embolism (CE), while rare, is being increasingly recognized as an important cause of AMI. We present the case of a patient with multi-site coronary artery embolization associated with hyperthyroid-related cardiomyopathy and atrial fibrillation. CASE PRESENTATION: A 49-year-old female with a history of hyperthyroidism and atrial fibrillation (AF) was admitted to our hospital presenting with right upper limb pain and swelling...
May 19, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28522204/peg-interferon-plus-nucleotide-analogue-treatment-versus-no-treatment-in-patients-with-chronic-hepatitis-b-with-a-low-viral-load-a-randomised-controlled-open-label-trial
#5
Annikki de Niet, Louis Jansen, Femke Stelma, Sophie B Willemse, Sjoerd D Kuiken, Sebastiaan Weijer, Carin M J van Nieuwkerk, Hans L Zaaijer, Richard Molenkamp, R Bart Takkenberg, Maarten Koot, Joanne Verheij, Ulrich Beuers, Hendrik W Reesink
BACKGROUND: Antiviral treatment is currently not recommended for patients with chronic hepatitis B with a low viral load. However, they might benefit from acquiring a functional cure (hepatitis B surface antigen [HBsAg] loss with or without formation of antibodies against hepatitis B surface antigen [anti-HBs]). We assessed HBsAg loss during peg-interferon-alfa-2a (peg-IFN) and nucleotide analogue combination therapy in patients with chronic hepatitis B with a low viral load. METHODS: In this randomised controlled, open-label trial, patients were enrolled from the Academic Medical Center (AMC), Amsterdam, Netherlands...
May 15, 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28521834/incidence-of-total-hip-or-knee-replacement-due-to-osteoarthritis-in-relation-to-thyroid-function-a-prospective-cohort-study-the-nord-tr%C3%A3-ndelag-health-study
#6
Alf Inge Hellevik, Marianne Bakke Johnsen, Arnulf Langhammer, Anne Marie Fenstad, Ove Furnes, Kjersti Storheim, John Anker Zwart, Gunnar Flugsrud, Lars Nordsletten
BACKGROUND: To study whether thyroid function was associated with risk of hip or knee replacement due to primary osteoarthritis. METHODS: In a prospective cohort study, data from the second and third survey of the Nord-Trøndelag Health Study were linked to the Norwegian Arthroplasty Register in order to identify total hip or knee replacement as a result of primary osteoarthritis. RESULTS: Among 37 891 participants without previously known thyroid disease we recorded 978 total hip replacements (THRs) and 538 total knee replacements (TKRs) during a median follow-up time of 15...
May 18, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28516372/does-thyroid-dysfunction-increase-the-risk-of-breast-cancer-a-systematic-review-and-meta-analysis
#7
REVIEW
Y Fang, L Yao, J Sun, R Yang, Y Chen, J Tian, K Yang, L Tian
PURPOSE: To investigate the relationship between hypothyroidism, hyperthyroidism, thyroid hormone replacement, and the risk of breast cancer. METHODS: We searched the PubMed, Cochrane Library, EMbase, Web of Science, and China Biology Medicine (CBM) databases through June 2016 to identify researches that assessed the relationship between thyroid dysfunction and the risk of breast cancer together with the impact of thyroid hormone substitution treatment on incidence of breast cancer...
May 17, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28511811/autoimmune-voltage-gated-potassium-channelopathy-presenting-with-catecholamine-excess
#8
K Amy Stepp, Christin Folker, Marie Tanzer, Jennifer Hayman, Thomas Reynolds, Leah Mallory
BACKGROUND: Autoimmune voltage-gated potassium channelopathies have been associated with a range of neurological presenting symptoms, including central, peripheral, and autonomic dysfunction. PATIENT DESCRIPTION: We describe a 12-year-old boy who presented with nine months of pain, anxiety, and 30-pound weight loss. He was admitted for failure to thrive, then noted to be persistently hypertensive and tachycardic. Plasma metanephrines and urine metanephrines and catecholamines were elevated...
April 8, 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/28509121/antithyroid-drug-associated-mpo-anca-positive-tubulointerstitial-nephritis-in-a-type-2-diabetes-patient-a-case-report
#9
Shinsuke Nishimura, Kazushi Nakao, Masaya Takeda, Ikuko Matsuura, Yoshihisa Nomura, Sonei Shojima, Yuriko Yamamura, Kazuyuki Fujita, Noriya Momoki, Keisuke Maruyama, Masahiro Yamamura, Makoto Hiramatsu
A 54-year-old man diagnosed with type 2 diabetes and hyperthyroidism was prescribed propylthiouracil (PTU) after the patient developed hepatic dysfunction on thiamazole. At 50 mg/day of PTU, he was stable with thyroid-stimulating hormone receptor and thyrotropic antibody titers remaining stable. After four years of taking PTU, he was referred to the Department of Nephrology due to a rapid increase in his serum creatinine (Cr) level. He showed impaired renal function (Cr 2.26 mg/dL; estimated glomerular filtration rate (eGFR), 25 mL/min)...
May 2017: CEN Case Reports
https://www.readbyqxmd.com/read/28508608/myopathy-in-pediatric-thyroid-states-a-review-of-the-literature
#10
Elena Dingle, Resmy Palliyil-Gopi, Maria Contreras, Brenda Kohn, Preneet Cheema Brar
This review highlights the presentations of myopathy in children in both hypothyroid and hyperthyroid states with an emphasis on the pathophysiology, diagnosis and treatment. Based on our review of the literature data, myopathy should be considered in all children presenting with muscular weakness or altered muscle enzymes in the context of thyroid disease.
December 2016: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/28502134/thyroid-dysfunctions-in-a-sample-of-egyptian-children-and-adolescents-with-systemic-lupus-erythematosus-relation-to-disease-activity-and-duration
#11
Hend H Abd-Elnabi, Mohamed A El-Gamasy, Maher A Abd-Elhafez
Systemic lupus erythematosus (SLE) is a chronic, autoimmune, inflammatory disease affects any organ of the body, including the thyroid gland. Both hypothyroidism and hyperthyroidism have been found in SLE patients more frequently than general population. The aim of this study was to evaluate the frequency of autoimmune thyroid dysfunctions in juvenile SLE and its relation to disease activity and duration. A prospective case-control study was carried on 40 children with juvenile SLE and 30 healthy as controls, all were subjected to measurement of serum TSH, Free T3, Free T4 and anti-TG by ELISA...
June 2016: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/28496371/dyschromatosis-symmetrica-hereditaria-with-cutaneous-lupus-erythematosus-and-hyperthyroidism
#12
Fahad Al-Saif, Ahmed Alhumidi, Rama Ayed Alhallaf
Dyschromatosis symmetrica hereditaria (DSH) is a rare genodermatosis characterized by various sizes of both hyper- and hypopigmented macules arranged in reticulated patterns on the face and the dorsal aspects of the extremities. There are also cutaneous and extracutaneous abnormalities, but they are rare. As far as we know, DSH associated with immune-mediated conditions has not been reported. We report the first case of DSH, which is associated with cutaneous lupus erythematosus and hyperthyroidism.
2017: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/28494633/comparison-of-in-clinic-point-of-care-and-reference-laboratory-total-thyroxine-immunoassays-for-diagnosis-and-post-treatment-monitoring-of-hyperthyroid-cats
#13
Mark E Peterson, Mark Rishniw, Graham E Bilbrough, Kate B Cote
Objectives The Catalyst One Chemistry Analyzer (IDEXX Laboratories) is a point-of-care instrument that can measure total thyroxine (TT4) by immunoassay. The aims of this study were to evaluate the analytic performance of the Catalyst TT4 assay in feline sera and to examine agreement of the Catalyst TT4 results with those measured by immunoassay at a veterinary reference laboratory. Methods Assay precision, reproducibility and linearity were evaluated for the Catalyst TT4 assay. For method comparison, TT4 concentrations in serum samples from 157 cats (127 hyperthyroid, 30 radioiodine-treated cats) were analyzed by both in-clinic and reference laboratory methods...
May 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28491434/life-threatening-haematological-complication-occurring-in-a-cat-after-chronic-carbimazole-administration
#14
Andrea Mosca, Luca Bresciani
CASE SUMMARY: An 11-year-old spayed female domestic shorthair cat with a history of hyperthyroidism treated with carbimazole for 7 months was presented for a check-up after a few episodes of vomiting. The cat had been receiving prednisolone at 0.5 mg/kg PO q12h for recent pancreatitis and concurrent inflammation of liver and small intestines confirmed by biopsies. Clinical examination revealed pale mucous membranes with a capillary refill time of <2 s. Haematology showed severely decreased packed cell volume (16%), and increased prothrombin time (42 s), partial thromboplastin time (>120 s) and fibrinogen serum concentration (3...
July 2016: JFMS Open Rep
https://www.readbyqxmd.com/read/28489513/thyroid-function-during-early-life-and-dental-development
#15
S Vucic, T I M Korevaar, B Dhamo, V W V Jaddoe, R P Peeters, E B Wolvius, E M Ongkosuwito
Children with low levels of thyroid hormones (hypothyroidism) have delayed tooth eruption, enamel hypoplasia, micrognathia, and anterior open bite, whereas children with hyperthyroidism may suffer from accelerated tooth eruption, maxillary, and mandibular osteoporosis. However, it is still unknown whether thyroid function variations within the normal or subclinical range also have an impact on hard dental tissues in healthy children. The objective of this study was, therefore, to investigate the association between thyroid function from the fetal period until early childhood and dental development at school age...
May 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28485783/influence-of-screening-and-intervention-of-hyperthyroidism-on-pregnancy-outcome
#16
Y Wang, X-L Sun, C-L Wang, H-Y Zhang
OBJECTIVE: To discuss the influence of screening and intervention of hyperthyroidism on pregnancy outcome. PATIENTS AND METHODS: The clinical data of 122 pregnant women who had been confirmed with hyperthyroidism from April 2012 to July 2014 in the Weifang People's Hospital were analyzed retrospectively (25 untreated, 97 treated). 60 with normal pregnancy check were randomly selected as control group. The pregnancy outcomes of the two groups of patients were analyzed...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28483784/thyroid-states-regulate-subcellular-glucose-phosphorylation-activity-in-male-mice
#17
Flavia Letícia Martins Peçanha, Reinaldo Sousa Dos Santos, Wagner Seixas da-Silva
The thyroid hormones (THs), triiodothyronine (T3) and thyroxine (T4), are very important in organism metabolism and regulate glucose utilization. Hexokinase (HK) is responsible for the first step of glycolysis, catalyzing the conversion of glucose to glucose 6-phosphate. HK has been found in different cellular compartments, and new functions have been attributed to this enzyme. The effects of hyperthyroidism on subcellular glucose phosphorylation in mouse tissues were examined. Tissues were removed, subcellular fractions isolated from eu- and hyperthyroid (T3, 0...
May 8, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28482002/thyroid-function-tests-in-the-reference-range-and-fracture-individual-participant-analysis-of-prospective-cohorts
#18
Carole E Aubert, Carmen Floriani, Douglas C Bauer, Bruno R da Costa, Daniel Segna, Manuel R Blum, Tinh-Hai Collet, Howard A Fink, Anne R Cappola, Lamprini Syrogiannouli, Robin P Peeters, Bjørn O Åsvold, Wendy Pj den Elzen, Robert N Luben, Alexandra P Bremner, Apostolos Gogakos, Richard Eastell, Patricia M Kearney, Mari Hoff, Erin Le Blanc, Graziano Ceresini, Fernando Rivadeneira, André G Uitterlinden, Kay-Tee Khaw, Arnulf Langhammer, David J Stott, Rudi Gj Westendorp, Luigi Ferrucci, Graham R Williams, Jacobijn Gussekloo, John P Walsh, Drahomir Aujesky, Nicolas Rodondi
Context: Hyperthyroidism is associated with increased fracture risk, but it is not clear if lower TSH and higher free thyroxine (FT4) in euthyroid individuals are associated with fracture risk. Objective: To evaluate the association of TSH and FT4 with incident fractures in euthyroid individuals. Design: Individual participant data analysis. Setting: Thirteen prospective cohort studies with baseline examinations between 1981 and 2002...
May 5, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28480843/prognostic-risk-of-obstetric-and-perinatal-complications-in-pregnant-women-with-thyroid-dysfunction
#19
N Morchiladze, B Tkeshelashvili, T Gagua, D Gagua
Maternal thyroid pathology takes important role in obstetric and peri-neonatal morbidity structure. Despite of the number of studies conducted in the field of thyroid disorders of pregnant females, the definition of influence of thyroid gland dysfunction on maternal and neonatal health still remains actual. The mentioned topics draw specific interest in the aspect of prognosticaiton of complications and unfavorable outcome. Aim of the study - to define the specificities of gestation period and determine the prognostic risk of obstetric and perinatal complications in pregnant females with thyroid pathology...
March 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28472357/thyroid-dysfunction-and-autoimmune-thyroid-diseases-among-atomic-bomb-survivors-exposed-in-childhood
#20
Misa Imaizumi, Waka Ohishi, Eiji Nakashima, Nobuko Sera, Kazuo Neriishi, Michiko Yamada, Yoshimi Tatsukawa, Ikuno Takahashi, Saeko Fujiwara, Keizo Sugino, Takao Ando, Toshiro Usa, Atsushi Kawakami, Masazumi Akahoshi, Ayumi Hida
Context: The risk of thyroid cancer increases and persists for decades among individuals exposed to ionizing radiation in childhood, while long-term effects of childhood exposure to medium to low doses radiation on thyroid dysfunction and autoimmune thyroid diseases have remained unclear. Objective: To evaluate radiation-dose responses for the prevalence of thyroid dysfunction and autoimmune thyroid disease among atomic -bomb survivors exposed in childhood. Design, Setting, and Participants: Hiroshima and Nagasaki atomic-bomb survivors who were younger than 10 years old at exposure underwent thyroid examinations at the Radiation Effects Research Foundation between 2007 and 2011, which was 62-66 years after the bombing...
May 1, 2017: Journal of Clinical Endocrinology and Metabolism
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