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Indocyanine green EPR

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https://www.readbyqxmd.com/read/26869546/feasibility-of-poly-ethylene-glycol-derivatives-as-diagnostic-drug-carriers-for-tumor-imaging
#1
Kengo Kanazaki, Kohei Sano, Akira Makino, Fumio Yamauchi, Atsushi Takahashi, Tsutomu Homma, Masahiro Ono, Hideo Saji
Poly(ethylene glycol) (PEG) is an artificial but biocompatible hydrophilic polymer that has been widely used in clinical products. To evaluate the feasibility of using PEG derivative itself as a tumor imaging carrier via an enhanced permeability and retention (EPR) effect, we prepared indium-111-labeled PEG ((111)In-DTPA-PEG) and indocyanine green (ICG)-labeled PEG (ICG-PEG) with PEG molecular weights of 5-40kDa and investigated their in vivo biodistribution in colon26 tumor-bearing mice. Thereafter, single-photon emission computed tomography (SPECT) and photoacoustic (PA) imaging studies were performed...
March 28, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/26585556/image-guided-tumor-surgery-will-there-be-a-role-for-fluorescent-nanoparticles
#2
REVIEW
Tanner K Hill, Aaron M Mohs
Image-guided surgery (IGS) using fluorescent nanoparticles (NPs) has the potential to substantially impact patient treatment. The use of fluorescence imaging provides surgeons with real-time feedback on the location of diseased tissue using safe, low-cost imaging agents and instrumentation. Fluorescent NPs are likely to play a role as they are capable of taking advantage of the enhanced permeability and retention (EPR) effect and can be modified to avoid clearance, increase circulation time, and specifically target tumors...
July 2016: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/26482083/micellar-formulation-of-indocyanine-green-for-phototherapy-of-melanoma
#3
Vaibhav Mundra, Yang Peng, Sandeep Rana, Amarnath Natarajan, Ram I Mahato
Phototherapy (PT), a light activated treatment modality, is a potential therapeutic option for the treatment of melanoma. In spite of the excellent safety profile and absorption in the near infrared (NIR) range, clinical potential of indocyanine green (ICG) as PT is limited by its short half-life and inefficient tumor accumulation. In this study, we have covalently conjugated ICG-NH2 to the pendant carboxyl groups of poly (ethylene glycol)-block-poly(2-methyl-2-carboxyl-propylene carbonate) (PEG-PCC) copolymer using carbodiimide coupling, which self-assembled into micelles with a particle size of 30-50 nm and high ICG loading...
December 28, 2015: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/26110901/the-value-of-intraoperative-near-infrared-fluorescence-imaging-based-on-enhanced-permeability-and-retention-of-indocyanine-green-feasibility-and-false-positives-in-ovarian-cancer
#4
Quirijn R J G Tummers, Charlotte E S Hoogstins, Alexander A W Peters, Cor D de Kroon, J Baptist M Z Trimbos, Cornelis J H van de Velde, John V Frangioni, Alexander L Vahrmeijer, Katja N Gaarenstroom
OBJECTIVE: In ovarian cancer, two of the most important prognostic factors for survival are completeness of staging and completeness of cytoreductive surgery. Therefore, intra-operative visualization of tumor lesions is of great importance. Preclinical data already demonstrated tumor visualization in a mouse-model using near-infrared (NIR) fluorescence imaging and indocyanine green (ICG) as a result of enhanced permeability and retention (EPR). The aim of this study was to determine feasibility of intraoperative ovarian cancer metastases imaging using NIR fluorescence imaging and ICG in a clinical setting...
2015: PloS One
https://www.readbyqxmd.com/read/23545239/evasion-from-accelerated-blood-clearance-of-nanocarrier-named-as-lactosome-induced-by-excessive-administration-of-lactosome
#5
Eri Hara, Akira Makino, Kensuke Kurihara, Manabu Sugai, Akira Shimizu, Isao Hara, Eiichi Ozeki, Shunsaku Kimura
BACKGROUND: Nanoparticle of Lactosome, which is composed of poly(l-lactic acid)-base depsipeptide with diameter of 35nm, accumulates in solid tumors by the enhanced permeability and retention (EPR) effect. However, a pharmacokinetic alteration of Lactosome was observed when Lactosome was repeatedly administered. This phenomenon is named as the Lactosome accelerated blood clearance (ABC) phenomenon. In this study, the effect of Lactosome dose on the ABC phenomenon was examined and discussed in terms of immune tolerance...
August 2013: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/22787518/intraoperative-near-infrared-fluorescence-imaging-with-novel-indocyanine-green-loaded-nanocarrier-for-spinal-metastasis-a-preliminary-animal-study
#6
Toru Funayama, Masataka Sakane, Tetsuya Abe, Isao Hara, Eiichi Ozeki, Naoyuki Ochiai
Marginal resection during resection of a spinal metastasis is frequently difficult because of the presence of important tissues such as the aorta, vena cava, and dura mater, including the spinal cord adjacent to the vertebral body. Thus, there is an urgent need for novel intraoperative imaging modalities with the ability to clearly identify bone metastasis. We have proposed a novel nanocarrier loaded with indocyanine green (ICG) (ICG-lactosome) with tumor selectivity attributable to its enhanced permeation and retention (EPR) effect...
2012: Open Biomedical Engineering Journal
https://www.readbyqxmd.com/read/22460632/tempol-protects-against-intravitreous-indocyanine-green-induced-retinal-damage-in-rats
#7
Sebastian Thaler, Bogomil Voykov, Gabriel Willmann, Michal Fiedorowicz, Robert Rejdak, Florian Gekeler, C Albrecht May, Andreas Schatz, Frank Schuettauf
PURPOSE: Indocyanine green (ICG) has been widely used as a vital dye for macular surgery. However, ICG can be toxic to retinal cells. Here we evaluate whether tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl), a free radical scavenger, can protect against ICG-induced retinal damage in rats. METHODS: Brown Norway rats received intravitreal injections of ICG 0.5 % or BSS as controls. Tempol (20 mg/kg BW) or PBS as a control was administered intraperitoneally 24 h and 30 min before ICG and once daily for 7 consecutive days...
November 2012: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/21469142/near-infrared-fluorescence-guided-real-time-endoscopic-detection-of-peritoneal-ovarian-cancer-nodules-using-intravenously-injected-indocyanine-green
#8
Nobuyuki Kosaka, Makoto Mitsunaga, Michelle R Longmire, Peter L Choyke, Hisataka Kobayashi
Near infrared fluorescence-guidance can be used for the detection of small cancer metastases and can aid in the endoscopic management of cancer. Indocyanine green (ICG) is a Food and Drug Administration (FDA)-approved fluorescence agent. Through non-specific interactions with serum proteins, ICG achieves enhanced permeability and retention (EPR) effects. Yet, ICG demonstrates rapid clearance from the circulation. Therefore, ICG may be an ideal contrast agent for real-time fluorescence imaging of tumors. To evaluate the usefulness of real-time dual fluorescence and white light endoscopic optical imaging to detect tumor implants using the contrast agent ICG, fluorescence-guided laparoscopic procedures were performed in mouse models of peritoneally disseminated ovarian cancers...
October 1, 2011: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/19525007/near-infrared-fluorescence-tumor-imaging-using-nanocarrier-composed-of-poly-l-lactic-acid-block-poly-sarcosine-amphiphilic-polydepsipeptide
#9
Akira Makino, Shinae Kizaka-Kondoh, Ryo Yamahara, Isao Hara, Tatsuya Kanzaki, Eiichi Ozeki, Masahiro Hiraoka, Shunsaku Kimura
A nanocarrier, lactosome, which is composed of poly(L-lactic acid)-block-poly(sarcosine), as a contrast agent for the liver tumor imaging was examined using the near infrared fluorescence (NIRF) optical imaging technique. Lactosome labeled with indocyanine green (ICG) showed a high escape ability from the reticulo-endothelial system (RES). Lactosome was found to be stable in a blood circulation, and gradually accumulated specifically at a model liver tumor site, which was obtained by graft of HepG2/EF-Luc cells at a mouse liver...
October 2009: Biomaterials
https://www.readbyqxmd.com/read/19206454/near-infrared-emitting-fluorophore-doped-calcium-phosphate-nanoparticles-for-in-vivo-imaging-of-human-breast-cancer
#10
Erhan I Altinoğlu, Timothy J Russin, James M Kaiser, Brian M Barth, Peter C Eklund, Mark Kester, James H Adair
Early detection is a crucial element for the timely diagnosis and successful treatment of all human cancers but is limited by the sensitivity of current imaging methodologies. We have synthesized and studied bioresorbable calcium phosphate nanoparticles (CPNPs) in which molecules of the near-infrared (NIR) emitting fluorophore, indocyanine green (ICG), are embedded. The ICG-CPNPs demonstrate exceptional colloidal and optical characteristics. Suspensions consisting of 16 nm average diameter particles are colloidally stable in physiological solutions (phosphate buffered 0...
October 28, 2008: ACS Nano
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