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Central aortic pressure

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https://www.readbyqxmd.com/read/28166118/all-extremity-exercise-training-improves-arterial-stiffness-in-older-adults
#1
Han-Kyul Kim, Chueh-Lung Hwang, Jeung-Ki Yoo, Moon-Hyon Hwang, Eileen M Handberg, John W Petersen, Wilmer W Nichols, Sofia Sofianos, Demetra D Christou
: Large elastic arteries stiffen with age which predisposes older adults to increased risk for cardiovascular disease. Aerobic exercise training is known to reduce the risk for cardiovascular disease, but the optimal exercise prescription for attenuating large elastic arterial stiffening in older adults is not known. PURPOSE: The purpose of this randomized controlled trial was to compare the effect of all-extremity high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on aortic pulse wave velocity (PWV) and carotid artery compliance in older adults...
February 4, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28165470/sodium-chloride-promotes-tissue-inflammation-via-osmotic-stimuli-in-subtotal-nephrectomized-mice
#2
Fumiko Sakata, Yasuhiko Ito, Masashi Mizuno, Akiho Sawai, Yasuhiro Suzuki, Takako Tomita, Mitsuhiro Tawada, Akio Tanaka, Akiyoshi Hirayama, Akihiro Sagara, Takashi Wada, Shoichi Maruyama, Tomoyoshi Soga, Seiichi Matsuo, Enyu Imai, Yoshifumi Takei
Chronic inflammation, which is often associated with high all-cause and cardiovascular mortality, is prevalent in patients with renal failure; however, the precise mechanisms remain unclear. High-salt intake was reported to induce lymphangiogenesis and autoimmune diseases via osmotic stimuli with accumulation of sodium or chloride. In addition, sodium was recently reported to be stored in the extremities of dialysis patients. We studied the effects and mechanisms of high salt loading on tissue and systemic inflammation in subtotal-nephrectomized mice (5/6Nx) and in cultured cells...
February 6, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/28164361/in-vivo-quantification-of-aortic-stiffness-using-mr-elastography-in-hypertensive-porcine-model
#3
Huiming Dong, Ria Mazumder, Venkata Sita Priyanka Illapani, Xiaokui Mo, Richard D White, Arunark Kolipaka
PURPOSE: Aortic stiffness plays an important role in evaluating and predicting the progression of systemic arterial hypertension (SAH). The aim of this study is to determine the stiffness of aortic wall using MR elastography (MRE) in a hypertensive porcine model and compare it against invasive aortic pressure measurements. METHODS: Renal wrapping surgery was performed on eight pigs to induce SAH. Aortic MRE was performed at baseline and 2 months postsurgery using a retrospectively pulse-gated gradient-echo MRE sequence on a 1...
February 5, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28159826/aortic-waveform-analysis-to-individualize-treatment-in-heart-failure
#4
Peter Wohlfahrt, Vojtech Melenovsky, Margaret M Redfield, Thomas P Olson, Grace Lin, Sahar S Abdelmoneim, Bernhard Hametner, Siegfried Wassertheurer, Barry A Borlaug
BACKGROUND: Afterload reduction is a cornerstone in the management of patients with heart failure (HF) and reduced ejection fraction. However, arterial load and the effect of HF therapies on afterload might vary between individuals. Tailoring vasoactive medicines to patients with HF based upon better understanding of arterial afterload may enable better individualization of therapy. METHODS AND RESULTS: Subjects with HF and reduced ejection fraction underwent aggressive titration of vasoactive HF therapies with assessment of central aortic waveforms analyzed using pulse wave, wave separation, and arterial reservoir models...
February 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28115510/abnormal-wave-reflections-and-left-ventricular-hypertrophy-late-after-coarctation-of-the-aorta-repair
#5
Michael A Quail, Rebekah Short, Bejal Pandya, Jennifer A Steeden, Abbas Khushnood, Andrew M Taylor, Patrick Segers, Vivek Muthurangu
Patients with repaired coarctation of the aorta are thought to have increased afterload due to abnormalities in vessel structure and function. We have developed a novel cardiovascular magnetic resonance protocol that allows assessment of central hemodynamics, including central aortic systolic blood pressure, resistance, total arterial compliance, pulse wave velocity, and wave reflections. The main study aims were to (1) characterize group differences in central aortic systolic blood pressure and peripheral systolic blood pressure, (2) comprehensively evaluate afterload (including wave reflections) in the 2 groups, and (3) identify possible biomarkers among covariates associated with elevated left ventricular mass (LVM)...
March 2017: Hypertension
https://www.readbyqxmd.com/read/28101819/high-central-aortic-rather-than-brachial-blood-pressure-is-associated-with-carotid-wall-remodeling-and-increased-arterial-stiffness-in-childhood
#6
Gonzalo Peluso, Victoria García-Espinosa, Santiago Curcio, Marco Marota, Juan Castro, Pedro Chiesa, Gustavo Giachetto, Daniel Bia, Yanina Zócalo
INTRODUCTION: In adults, central blood pressure (cBP) is reported to associate target organ damages (TODs) rather than peripheral blood pressure (pBP). However, data regarding the association of pre-clinical TODs with cBP and pBP in pediatric populations are scarce. AIM: To evaluate in children and adolescents the importance of cBP and pBP levels, in terms of their association with hemodynamic and vascular changes. METHODS: 315 subjects [age (mean/range) 12/8-18 years] were included...
January 19, 2017: High Blood Pressure & Cardiovascular Prevention: the Official Journal of the Italian Society of Hypertension
https://www.readbyqxmd.com/read/28093466/effects-of-sacubitril-valsartan-versus-olmesartan-on-central-hemodynamics-in-the-elderly-with-systolic-hypertension-the-parameter-study
#7
Bryan Williams, John R Cockcroft, Kazuomi Kario, Dion H Zappe, Patrick C Brunel, Qian Wang, Weinong Guo
Effective treatment of systolic hypertension in elderly patients remains a major therapeutic challenge. A multicenter, double-blind, randomized controlled trial with sacubitril/valsartan (LCZ696), a first-in-class angiotensin receptor neprilysin inhibitor, was conducted to determine its effects versus olmesartan (angiotensin receptor blocker) on central aortic pressures, in elderly patients (aged ≥60 years) with systolic hypertension and pulse pressure >60 mm Hg, indicative of arterial stiffness. Patients (n=454; mean age, 67...
March 2017: Hypertension
https://www.readbyqxmd.com/read/28091867/arterial-aortic-stiffness-in-patients-with-resistant-hypertension-from-assessment-to-treatment
#8
REVIEW
James E Sharman, Pierre Boutouyrie, Stéphane Laurent
PURPOSE OF REVIEW: The purpose of the review is to examine whether measurement of aortic stiffness could be especially value-adding for risk stratification and treatment among patients with resistant hypertension (RH). RECENT FINDINGS: Adverse arterial remodeling and increased aortic stiffness is associated with RH, and it may be of additional clinical benefit to measure aortic stiffness in these patients. However, there is insufficient evidence to determine whether aortic stiffness is excessively high relative to the level of blood pressure (BP) among people with RH...
January 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28087911/-aortic-stiffness-and-its-influencing-factors-in-patients-with-chronic-kidney-disease
#9
Binxian Ye, Li Zhao, Wei Shen, Yan Ren, Bo Lin, Maosheng Chen, Junda Tang, Xinxin Jiang, Yiwen Li, Qiang He
Objective: To investigate the changes of aortic stiffness and its influencing factors in patients with chronic kidney diseases (CKD). Methods: Eightyfour patients with CKD from Department of Nephrology, Zhejiang Provincial People's Hospital were divided into the dialysis group (CKD stage 5, n=48) and non-dialysis group (CKD stage 3-5, n=36). Clinical data, biochemical parameters and echocardiography findings were collected. SphygmoCor pulse wave analysis system was used to obtain pulse wave analysis (PWA) parameters including central aortic systolic blood pressure (CSP), central pulse pressure (CPP), augmented pressure (AP), augmentation index (AIX), and heart rate 75-adjusted augmentation index (HR75AIX)...
May 25, 2016: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://www.readbyqxmd.com/read/28077859/benefits-of-whole-body-vibration-training-on-arterial-function-and-muscle-strength-in-young-overweight-obese-women
#10
Stacey Alvarez-Alvarado, Salvador J Jaime, Michael J Ormsbee, Jeremiah C Campbell, Joy Post, Jacob Pacilio, Arturo Figueroa
The early arterial dysfunction linked with obesity and a sedentary lifestyle heightens the likelihood of suffering from future cardiovascular events. Whole-body vibration training (WBVT) may improve systemic arterial stiffness (brachial-ankle pulse wave velocity (baPWV)) and muscle strength in pre- and post-menopausal women. However, the effectiveness of WBVT to impact the arterial segments included in baPWV is unknown. The aim of this study was to investigate the effects of WBVT on aortic and leg arterial stiffness in young sedentary overweight/obese women...
January 12, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/28077421/aortic-wave-reflection-during-orthostatic-challenges-influence-of-body-position-and-venous-pooling
#11
William E Hughes, Darren P Casey
BACKGROUND: Aortic wave reflection (augmentation index; AIx) decreases during orthostatic challenges despite increased peripheral resistance, which is thought to be due to venous pooling. The purpose of this study was to examine if the decrease in AIx during an orthostatic challenge is due to venous pooling alone or body position manipulation. METHODS: Twenty-three young, healthy adults (11F/12M) participated in 3 separate orthostatic challenges (5 minutes each); 60° head-up tilt (HUT), 60° HUT with bilateral rhythmic blood pressure (BP) cuff inflation on calves (75 mm Hg) to minimize venous pooling, and lower body negative pressure (LBNP; -30 mm Hg) for venous pooling independent of body position...
February 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28076633/statins-for-aortic-valve-stenosis
#12
Luciana Thiago, Selma Rumiko Tsuji, Jonathan Nyong, Maria Eduarda Dos Santos Puga, Aécio Flávio Teixeira de Góis, Cristiane Rufino Macedo, Orsine Valente, Álvaro Nagib Atallah
BACKGROUND: Aortic valve stenosis is the most common type of valvular heart disease in the USA and Europe. Aortic valve stenosis is considered similar to atherosclerotic disease. Some studies have evaluated statins for aortic valve stenosis. OBJECTIVES: To evaluate the effectiveness and safety of statins in aortic valve stenosis. METHODS: Search methods: We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase, LILACS - IBECS, Web of Science and CINAHL Plus...
November 2016: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/28065687/restless-legs-syndrome-and-cardiovascular-disease-a-research-roadmap
#13
REVIEW
Daniel J Gottlieb, Virend K Somers, Naresh M Punjabi, John W Winkelman
In this paper, we first critically appraise the epidemiologic literature examining the association of restless legs syndrome (RLS) with cardiovascular disease (CVD) and then consider whether lessons learned from the study of cardiovascular consequences of other sleep disorders might inform a research agenda to examine the potential mechanisms of cardiovascular morbidity of RLS. Cross-sectional and longitudinal studies are both mixed as to whether there is a meaningful association of RLS and CVD. On the other hand, numerous cross-sectional and longitudinal observational studies have shown a strong association of obstructive sleep apnea (OSA) with CVD risk...
October 27, 2016: Sleep Medicine
https://www.readbyqxmd.com/read/28063813/assessment-of-vascular-function-in-low-socioeconomic-status-preschool-children-a-pilot-study
#14
Lama Ghazi, Tanja Dudenbostel, Daisy Xing, Deborah Ejem, Anne Turner-Henson, Cynthia Irwin Joiner, Olivia Affuso, Andres Azuero, Suzanne Oparil, David A Calhoun, Marti Rice, Fadi G Hage
Elevated brachial blood pressure (BP) in childhood tracks into adulthood. Central BP and measures of arterial stiffness, such as aortic augmentation index (AIx) and pulse wave velocity (PWV), have been associated with future cardiovascular disease. This pilot study assessed the feasibility of noninvasively measuring these parameters in preschool children and explored factors that may be associated with elevated BP in this age group. Brachial BP was measured using an electronic oscillometric unit (Dinamap PRO 100) and defined as elevated when systolic BP (SBP) and/or diastolic BP (DBP) was ≥ the 90th percentile for age, gender, and height...
December 24, 2016: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/28038807/sheath-placement-in-femoral-artery-during-cardiac-catheterization-in-children-can-influence-pressure-waveform
#15
Masahiro Shiraishi, Tomoaki Murakami, Tomohiro Nawa, Kouji Higashi, Hiromichi Nakajima, Hiroyuki Aotsuka
INTRODUCTION: It is reported that pressure wave reflection is enhanced by external compression of the femoral artery. Therefore, it is possible that cardiac catheterization itself can influence the aortic pressure waveform. AIM: The purpose of this study is to clarify the influence of sheath placement in a femoral artery on the pressure waveform. METHODS: This study enrolled 21 pediatric patients (5.1±4.0years) who underwent cardiac catheterization...
March 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28025312/performance-of-the-labcor-dokimos-plus-pericardial-aortic-prosthesis-a-single-centre-experience
#16
Rashad Zayat, Jessica Arias-Pinilla, Ali Aljalloud, Giulia Musetti, Andreas Goetzenich, Rüdiger Autschbach, Thomas van Gemmeren, Andreas Niedeggen, Nima Hatam
OBJECTIVES: In patients with a small aortic annulus, aortic valve replacement (AVR) is frequently associated with high residual pressure gradients. Supra-annular pericardial aortic prostheses are gaining popularity due to the increased effective orifice areas (EOA) and resulting lower gradients. This study reports the clinical and echocardiographic results following implantation of the new supra-annular pericardial aortic prosthesis Dokimos Plus (Labcor, Belo Horizonte, Brazil). METHODS: Between October 2013 and July 2015, 137 patients (41% women, mean age: 74 years) underwent supra-annular AVR with or without concomitant procedures using the Dokimos Plus prosthesis in our department...
December 26, 2016: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28006821/src-1-regulates-blood-pressure-and-aortic-stiffness-in-female-mice
#17
Antentor Othrell Hinton, Yongjie Yang, Ann P Quick, Pingwen Xu, Chitra L Reddy, Xiaofeng Yan, Corey L Reynolds, Qingchun Tong, Liangru Zhu, Jianming Xu, Xander H T Wehrens, Yong Xu, Anilkumar K Reddy
Framingham Heart Study suggests that dysfunction of steroid receptor coactivator-1 may be involved in the development of hypertension. However, there is no functional evidence linking steroid receptor coactivator-1 to the regulation of blood pressure. We used immunohistochemistry to map the expression of steroid receptor coactivator-1 protein in mouse brain, especially in regions implicated in the regulation of blood pressure. Steroid receptor coactivator-1 protein was found in central amygdala, medial amygdala, supraoptic nucleus, arcuate nucleus, ventromedial, dorsomedial, paraventricular hypothalamus, and nucleus of the solitary tract...
2016: PloS One
https://www.readbyqxmd.com/read/28005702/time-to-the-peak-of-the-aortic-forward-wave-determines-the-impact-of-aortic-backward-wave-and-pulse-pressure-on-left-ventricular-mass
#18
Grace Tade, Gavin R Norton, Hendrik L Booysen, Moekanyi J Sibiya, Imraan Ballim, Pinhas Sareli, Elena Libhaber, Olebogeng H I Majane, Angela J Woodiwiss
AIM: To determine the degree to which an extended time to the peak of the aortic forward wave or early wave reflection time enhance associations between aortic backward wave pressure and hence central aortic pulse pressure (PPc) and left ventricular mass index (LVMI). METHODS: In 701 adult participants from a community sample either receiving no antihypertensive therapy or receiving low-dose thiazide diuretic monotherapy for at least a year (the major therapy employed), we assessed aortic haemodynamics (SphygmoCor software and wave separation analysis; AtCor Medical, West Ryder, New South Wales, Australia) and LVMI (echocardiography)...
February 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28003268/inhibition-of-srf-myocardin-reduces-aortic-stiffness-by-targeting-vascular-smooth-muscle-cell-stiffening-in-hypertension
#19
Ning Zhou, Jia-Jye Lee, Shaunrick Stoll, Ben Ma, Robert Wiener, Charles Wang, Kevin D Costa, Hongyu Qiu
AIMS: Increased aortic stiffness is a fundamental manifestation of hypertension. However, the molecular mechanisms involved remain largely unknown. We tested the hypothesis that abnormal intrinsic vascular smooth muscle cell (VSMC) mechanical properties in large arteries, but not in distal arteries, contribute to the pathogenesis of aortic stiffening in hypertension, mediated by the serum response factor (SRF)/myocardin signalling pathway. METHODS AND RESULTS: Four month old male spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats were studied...
February 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/27993753/reactive-myocardial-hyperemia-for-functional-assessment-of-coronary-stenosis-severity
#20
Michael Stoller, Christian Seiler
AIM: To compare functional assessment of coronary stenosis severity by fractional flow reserve (FFR) measurement as induced by systemic adenosine and by regional reactive myocardial hyperemia. METHODS AND RESULTS: The primary study endpoints were coronary pressure-derived FFR values in response to intravenous adenosine infusion (140µg/min/kg) and to a 1-minute proximal coronary artery balloon occlusion (reactive hyperemia) for the same stenosis of interest. The secondary study endpoint was coronary collateral flow index (CFI) during the same occlusion...
December 20, 2016: EuroIntervention
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