keyword
MENU ▼
Read by QxMD icon Read
search

decompensated liver disease

keyword
https://www.readbyqxmd.com/read/28915795/future-complications-of-chronic-hepatitis-c-in-a-low-risk-area-projections-from-the-hepatitis-c-study-in-northern-norway
#1
H Kileng, L Bernfort, T Gutteberg, O S Moen, M G Kristiansen, E J Paulssen, L K Berg, J Florholmen, R Goll
BACKGROUND: Hepatitis C (HCV) infection causes an asymptomatic chronic hepatitis in most affected individuals, which often remains undetected until cirrhosis and cirrhosis-related complications occur. Screening of high-risk subjects in Northern Norway has revealed a relatively low prevalence in the general population (0.24%). Despite this, late complications of HCV infection are increasing. Our object was to estimate the future prevalence and complications of chronic HCV infection in the period 2013-2050 in a low-risk area...
September 16, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28911947/albumin-prevents-infections-in-patients-with-chronic-liver-failure-in-a-single-arm-feasibility-trial
#2
Louise China, Simon S Skene, Zainib Shabir, Alexander Maini, Yvonne Sylvestre, Kate Bennett, Scott Bevan, James O'Beirne, Ewan Forrest, Jim Portal, Steve Ryder, Gavin Wright, Derek W Gilroy, Alastair O'Brien
BACKGROUND & AIMS: Infections are life threatening to patients with acute decompensation and acute-on-chronic liver failure (AD/ACLF). Patients with AD/ACLF have prostaglandin E2-mediated immune suppression, which can be reversed by administration of albumin; infusion of 20% human albumin solution (HAS) might improve outcomes of infections. We performed a feasibility study to determine optimal trial design, assess safety, and validate laboratory assessments of immune function to inform design of a phase 3 trial...
September 11, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28901345/-acute-alcoholic-hepatitis
#3
Gianni Testino, Emanuele Scafato, Valentino Patussi
Chronic alcohol related liver disease is characterized by a cascade of events defined as follows: steatosis, steatohepatitis/steatofibrosi, cirrhosis and hepatocellular carcinoma. On one of these histologic patterns may overlap acute alcoholic hepatitis (AAE) (mild, moderate, severe). Severe AAE can cause a severe clinical picture: jaundice with a duration of less than three months, jaundice in the first decompensation event, serum bilirubin higher than 5 mg/dL, ratio AST/ALT >2:1, AST less than 500 IU/L ALT <300 IU/L, neutrophil leukocytosis and increased GGT...
September 2017: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/28898796/transjugular-biopsy-case-report-of-inferior-vena-cava-hepatocellular-carcinoma-with-intracardiac-extension
#4
Laurence Weinberg, Diana Abu-Ssaydeh, Chris Macgregor, Jason Wang, Clarence Wong, Manfred Spanger, Vijayragavan Muralidharan
BACKGROUND: Diagnosis of hepatocellular carcinoma (HCC) can be established with near certainty by correlating radiological imaging with clinical presentation. However, in the absence of diagnostic certainty, biopsy of liver tissue is mandatory for optimal management. We present our management of a patient with advanced liver disease who presented with an IVC mass extending into the right atrium, with co-existing liver lesions not meeting criteria for an imaging diagnosis of HCC. CASE PRESENTATION: A 62-year-old male with Child-Pugh C liver cirrhosis presented with decompensated liver failure...
September 5, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28894136/soluble-intercellular-adhesion-molecule-1-is-associated-with-hepatocellular-carcinoma-risk-multiplex-analysis-of-serum-markers
#5
Vincent L Chen, An K Le, Ondrej Podlaha, Jacqueline Estevez, Biao Li, Philip Vutien, Ellen T Chang, Yael Rosenberg-Hasson, Stefan Pflanz, Zhaoshi Jiang, Dongliang Ge, Anuj Gaggar, Mindie H Nguyen
Individualized assessment of hepatocellular carcinoma (HCC) risk in chronic liver disease remains challenging. Serum biomarkers including cytokines may offer helpful adjuncts to standard parameters for risk prediction. Our aim was to identify markers associated with increased HCC incidence. This was a prospective cohort study of 282 patients with both viral or non-viral chronic liver disease. Baseline serum cytokines and other markers were measured in multiplex with a commercially-available Luminex-based system...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28887858/liver-transplantation-equity-supply-demand-and-access
#6
EDITORIAL
David Axelrod, Heidi Yeh
Despite advances in treatment for end stage liver disease (ESLD), death from cirrhosis and chronic liver disease remains a major source of morbidity and mortality, particularly in younger patients. The National Center for Health Statistics estimates that the years of life lost prior to age 75 due to ESLD has increased from 164.1 per 100,000 in 2000 to 190.3 in 2015, exceeding life years lost from cerebrovascular disease (161.0), colorectal cancer (123.3), and HIV (50.4).(1) Liver transplantation is the sole treatment for patients with decompensated liver failure, with exceptional success among patients who make it through transplant...
September 9, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28879721/value-of-red-cell-distribution-width-in-assessing-the-severity-of-hepatitis-b-virus-related-decompensated-cirrhosis
#7
Meiyu Zhang, Siyuan Chen, Xuan Zhu, Aidan Huang, Fang Lan, Huaping Chen, Shan Li, Xue Qin
BACKGROUND: Hepatitis B virus infection is the main reason for liver cirrhosis in China. Thus, evaluating the disease severity of hepatitis B-related decompensated cirrhosis (HBV-DeCi) is very important. The red cell distribution width (RDW) is thought to be correlated with the severity of various diseases. The purpose of this investigation is to verify whether RDW can estimate the disease severity of HBV-DeCi. METHODS: This retrospective study included 172 subjects who had been diagnosed with HBV-DeCi...
September 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28877719/absolute-quantification-of-microparticles-by-flow-cytometry-in-ascites-of-patients-with-decompensated-cirrhosis-a-cohort-study
#8
Cornelius Engelmann, Katrin Splith, Sandra Krohn, Adam Herber, Albrecht Boehlig, Stephan Boehm, Johann Pratschke, Thomas Berg, Moritz Schmelzle
BACKGROUND: Microparticles (MPs) are small (<1 μm) cell membrane-derived vesicles that are formed in response to cellular activation or early stages of apoptosis. Increased plasma MP levels have been associated with liver disease severity. Here we investigated the clinical impact of ascites MPs in patients with decompensated liver cirrhosis. METHODS: Ascites and blood samples of 163 patients with cirrhosis (ascites n = 163, blood n = 31) were collected between February 2011 and December 2012...
September 6, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28870670/il-1-receptor-like-1-protects-against-alcoholic-liver-injury-by-limiting-nf-%C3%AE%C2%BAb-activation-in-hepatic-macrophages
#9
Meng Wang, Guannan Shen, Liangguo Xu, Xiaodong Liu, Jared M Brown, Dechun Feng, Ruth Ann Ross, Bin Gao, Suthat Liangpunsakul, Cynthia Ju
BACKGROUND & AIM: Alcohol consumption, through increasing intestinal permeability and causing hepatocytes damage, leads to the release of pathogen- and damage-associated molecular pattern molecules (PAMPs and DAMPs). These molecules stimulate hepatic macrophages (MΦs) and activate NF-κB, resulting in inflammation and exacerbating alcoholic liver disease (ALD). However, much less is known about the mechanisms attenuating inflammation and preventing disease progression in the majority of the heavy drinkers...
September 1, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28859868/albumin-counteracts-immune-suppressive-effects-of-lipid-mediators-in-patients-with-advanced-liver-disease
#10
Louise China, Alexander Maini, Simon S Skene, Zainib Shabir, Yvonne Sylvestre, Romain A Colas, Lucy Ly, Natalia Becares Salles, Vittorio Belloti, Jesmond Dalli, Derek W Gilroy, Alastair O'Brien
BACKGROUND & AIMS: Patients with acute decompensation and acute on chronic liver failure (AD/ACLF) have immune dysfunction, which increases their risk for infections; however there are no effective treatments to restore their immune function. We investigated whether the potentially immune-restorative effects of albumin are mediated by its effects on prostaglandin E2 (PGE2) and other lipids. METHODS: We analyzed bloods samples from 45 of 79 patients with AD/ACLF and serum levels of albumin less than 30g/L for whom infusion of 20% human albumin solution (HAS) increased serum levels of albumin 30 g/L or more in a feasibility study of effects of 20% HAS...
August 28, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28856290/recommendations-for-the-treatment-of-hepatitis-c-in-2017
#11
REVIEW
Waldemar Halota, Robert Flisiak, Jacek Juszczyk, Piotr Małkowski, Małgorzata Pawłowska, Krzysztof Simon, Krzysztof Tomasiewicz
The goals of treatment is to eliminate HCV infection, stop or reverse histological changes, reduce the risk of hepatocellular carcinoma development and transmission of the infection to other individuals. According to the recommendation of the Polish Group of Experts for HCV in 2017 all patients with chronic HCV infection should receive treatment, but it is not recommended in patients at high risk of short overall survival. If access to therapy is restricted, priority should be given to patients whose HCV infection can lead to an unfavourable outcome of the disease within a short time frame, particular to individuals with liver cirrhosis, rapidly progressing liver fibrosis, extrahepatic manifestations of HCV infection, chronic kidney diseases, patients before and after organ transplantation...
June 2017: Clin Exp Hepatol
https://www.readbyqxmd.com/read/28845110/prioritization-for-interferon-free-regimens-and-potential-drug-interactions-of-current-direct-acting-anti-hepatitis-c-agents-in-routine-clinical-practice
#12
Μargarita Papatheodoridi, George N Dalekos, John Goulis, Spilios Manolakopoulos, Christos Triantos, Kalliopi Zachou, Argyro Koukoufiki, Αnastasia Κourikou, Κonstantinos Ζisimopoulos, Christos Τsoulas, George V Papatheodoridis
BACKGROUND: We determined the proportions of patients with chronic hepatitis C (CHC) in association with possible prioritized indications for interferon-free regimens and the use of co-medications with potential drug-drug interactions (DDIs). METHODS: Five hundred consecutive mono-infected CHC patients seen in 2015 at 5 Greek centers were included. Priorities for interferon-free regimens were based on liver disease severity, contraindication(s) for interferon and prior interferon-treatment failure...
2017: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/28844314/acute-kidney-injury-in-acute-on-chronic-liver-failure-where-does-hepatorenal-syndrome-fit
#13
REVIEW
Andrew Davenport, Mohammed Faisal Sheikh, Edmund Lamb, Banwari Agarwal, Rajiv Jalan
Renal dysfunction occurs in 25% to 50% of patients with cirrhosis admitted to the hospital with an acute episode of hepatic decompensation and may be due to underlying chronic kidney disease, an acute deterioration, or both. An acute deterioration in renal function in cirrhotic patients is now collectively referred to as acute kidney injury (AKI), which has been subclassified into different grades of severity that identify prognostic groups. Acute-on-chronic liver failure is characterized by acute hepatic and/or extrahepatic organ failure driven by a dysregulated immune response and systemic inflammatory response...
August 23, 2017: Kidney International
https://www.readbyqxmd.com/read/28843665/balanced-haemostasis-with-both-hypo-and-hyper-coagulable-features-in-critically-ill-patients-with-acute-on-chronic-liver-failure
#14
Caleb Fisher, Vishal C Patel, Sidsel Hyldgaard Stoy, Arjuna Singanayagam, Jelle Adelmeijer, Julia Wendon, Debbie L Shawcross, Ton Lisman, William Bernal
BACKGROUND: Cirrhotic patients have complex haemostatic abnormalities. Current evidence suggests stable cirrhotic (SC) patients have a "re-balanced" haemostatic state. However, limited data exists in acute decompensated (AD) or acute on chronic liver failure (ACLF) patients. METHODS: We utilised thrombin generation analysis, fibrinolysis assessment, and evaluation of haemostatic parameters to assess haemostasis in liver disease of progressive severity. RESULTS: The study cohorts were comprised of: SC, n=8; AD n=44; ACLF, n=17; and Healthy Control (HC), n=35...
August 17, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28839884/integration-of-palliative-and-supportive-care-in-the-management-of-advanced-liver-disease-development-and-evaluation-of-a-prognostic-screening-tool-and-supportive-care-intervention
#15
Benjamin E Hudson, Kelly Ameneshoa, Anya Gopfert, Rachael Goddard, Karen Forbes, Julia Verne, Peter Collins, Fiona Gordon, Andrew J Portal, Colette Reid, C Anne McCune
BACKGROUND AND OBJECTIVES: Patients with decompensated cirrhosis rarely receive palliative and supportive care interventions, which are routine in other life-limiting diseases. We aimed to design and evaluate a prognostic screening tool to routinely identify inpatients with decompensated cirrhosis at high risk of dying over the coming year, alongside the development of a supportive care intervention. DESIGN: Clinical notes from consecutive patients admitted as an emergency to University Hospitals Bristol with a diagnosis of cirrhosis over two distinct 90-day periods were scrutinised retrospectively for the presence or absence of five evidence-based factors associated with poor prognosis...
January 2017: Frontline Gastroenterology
https://www.readbyqxmd.com/read/28838457/coexistent-end-stage-nonalcoholic-steatohepatitis-and-colon-cancer-should-we-do-liver-transplantation
#16
V Aliyev, K Yasuchika, A Hammad, A Badawy, Y Nigmet, T Tajima, K Fukumitsu, S Yagi, K Hata, H Okajima, S Uemoto
BACKGROUND: Colon cancer accompanying decompensated liver cirrhosis is a rare clinical condition. Usually, treatment of colon cancer is prioritized, with cirrhosis dealt with later. CASE REPORT: We present a case of end-stage liver disease due to nonalcoholic steatohepatitis evaluated for living donor liver transplant. During the pretransplant examination, an ascending colon cancer was detected. Liver function was too poor to perform colon resection first. Simultaneous living donor liver transplant and colonic resection were carried out...
September 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28811718/chronic-liver-failure-consortium-acute-on-chronic-liver-failure-and-acute-decompensation-scores-predict-mortality-in-brazilian-cirrhotic-patients
#17
Rafael Veiga Picon, Franciele Sabadin Bertol, Cristiane Valle Tovo, Ângelo Zambam de Mattos
AIM: To validate prognostic scores for acute decompensation of cirrhosis and acute-on-chronic liver failure in Brazilian patients. METHODS: This is a prospective cohort study designed to assess the prognostic performance of the chronic liver failure-consortium (CLIF-C) acute decompensation score (CLIF-C AD) and CLIF-C acute-on-chronic liver failure score (CLIF-C ACLF), regarding 28-d and 90-d mortality, as well as to compare them to other prognostic models, such as Model for End-Stage Liver Disease (MELD), MELD Sodium (MELD-Na), Child-Pugh (CP) score, and the CLIF-C Organ Failure score (CLIF-C OF)...
July 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28809733/circulating-levels-of-pentraxin-3-ptx3-in-patients-with-liver-cirrhosis
#18
Janaína L Narciso-Schiavon, Jéssica G Pereira, Telma Erotides Silva, Emília T O Bansho, Edelton F Morato, José T Pinheiro, Letícia Muraro-Wildner, Maria Luiza Bazzo, Esther Buzaglo Dantas-Corrêa, Leonardo L Schiavon
BACKGROUND: Despite the circulating levels of PTX3 were related to the severity of various diseases, there are no studies investigating its role in patients with liver cirrhosis. We aimed to study PTX3 levels in patients with liver cirrhosis. MATERIAL AND METHODS: A prospective cohort study included 130 patients hospitalized for acute decompensation of liver cirrhosis, 29 stable cirrhotic outpatients and 32 healthy controls evaluated in a tertiary hospital in Southern Brasil...
August 8, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28803953/fibrosis-stage-but-not-nash-predicts-mortality-and-time-to-development-of-severe-liver-disease-in-biopsy-proven-nafld
#19
Hannes Hagström, Patrik Nasr, Mattias Ekstedt, Ulf Hammar, Per Stål, Rolf Hultcrantz, Stergios Kechagias
BACKGROUND AND AIMS: Non-alcoholic fatty liver disease (NAFLD) is highly common in the general population, but identifying patients with increased risk for mortality and liver-specific morbidity remains a challenge. Non-alcoholic steatohepatitis (NASH) is thought to enhance this risk; therefore, resolution of NASH is a major endpoint in current pharmacologic studies. METHODS: We conducted a retrospective cohort study of 646 biopsy-proven NAFLD patients. Each case was matched for age, sex and municipality to ten controls...
August 10, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28802062/modeling-the-epidemic-of-nonalcoholic-fatty-liver-disease-demonstrates-an-exponential-increase-in-burden-of-disease
#20
Chris Estes, Homie Razavi, Rohit Loomba, Zobair Younossi, Arun J Sanyal
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) and resulting nonalcoholic steatohepatitis (NASH) are highly prevalent in the US, where they are a growing cause of cirrhosis and hepatocellular carcinoma (HCC), and increasingly, an indicator for liver transplantation. METHODS: A Markov model was used to forecast NAFLD disease progression. Incidence of NAFLD was based on historical and projected changes in adult prevalence of obesity and type 2 diabetes mellitus (DM)...
August 12, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
keyword
keyword
108576
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"