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https://www.readbyqxmd.com/read/29223389/a-multi-institutional-prospective-trial-in-the-veterans-affairs-health-system-confirms-the-4kscore-maintains-its-predictive-value-among-african-american-men
#1
Sanoj Punnen, Stephen J Freedland, Thomas J Polascik, Stacy Loeb, Michael C Risk, Stephen Savage, Sharad C Mathur, Edward Uchio, Yan Dong, Jonathan L Silberstein
PURPOSE: The 4Kscore test accurately detects aggressive prostate cancer and reduces unnecessary biopsies, however, its performance in African American (AA) men is unknown. This study assessed the performance of the 4Kscore test in a cohort of men with a large AA representation. MATERIALS AND METHODS: Men referred for a biopsy of the prostate at eight Veteran's Affairs Medical centers were prospectively enrolled. All men underwent phlebotomy for 4Kscore test assessment prior to biopsy of the prostate...
December 6, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29223190/educational-effects-on-ascertain-dementia-8-item-informant-questionnaire-to-detect-dementia-in-the-taiwanese-population
#2
Sz-Fan Chen, Ming-Hsiung Liu, Nai-Ching Chen, Horng-Dean Horng, Wen-Lung Tsao, Chiung-Chih Chang, Ya-Ting Chang
BACKGROUND: Dementia screening is a public health priority in Taiwan, where the prevalence of dementia is increasing because of an aging population. However, the reasons affect community-dwelling people to accept a referral to memory specialist clinic after dementia screening was still unclear. To investigate the feasibility, acceptability, sensitivity, and specificity of the ascertain dementia 8-item informant questionnaire (AD8) to screen for patients with cognitive impairments in Taiwan's primary healthcare system...
December 10, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/29220407/respiratory-resistance-and-reactance-in-adults-with-sickle-cell-anemia-correlation-with-functional-exercise-capacity-and-diagnostic-use
#3
Cirlene de Lima Marinho, Maria Christina Paixão Maioli, Jorge Luis Machado do Amaral, Agnaldo José Lopes, Pedro Lopes de Melo
BACKGROUND: The improvement in sickle cell anemia (SCA) care resulted in the emergence of a large population of adults living with this disease. The mechanisms of lung injury in this new population are largely unknown. The forced oscillation technique (FOT) represents the current state-of-the-art in the assessment of lung function. The present work uses the FOT to improve our knowledge about the respiratory abnormalities in SCA, evaluates the associations of FOT with the functional exercise capacity and investigates the early detection of respiratory abnormalities...
2017: PloS One
https://www.readbyqxmd.com/read/29217447/early-experience-with-fenestrated-endovascular-compared-to-open-repair-of-complex-abdominal-aortic-aneurysms-in-a-high-volume-open-aortic-center
#4
Sarah E Deery, Robert T Lancaster, Anna M Gubala, Thomas F X O'Donnell, Christopher J Kwolek, Mark F Conrad, Richard P Cambria, Virendra I Patel
OBJECTIVE: Early data suggest that FEVAR is feasible but may have higher morbidity and unclear durability compared to open surgical repair (OSR) of complex abdominal aortic aneurysms (CAAA). We compared the early experience following elective FEVAR to traditional OSR of CAAA in a high-volume open aortic center. METHODS: All patients undergoing FEVAR and OSR for elective CAAA from 1/2010-7/2015 were identified. Univariate, multivariable logistic, and Cox hazards modeling were used to compare perioperative and intermediate outcomes...
December 4, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29216923/supervised-learning-for-infection-risk-inference-using-pathology-data
#5
Bernard Hernandez, Pau Herrero, Timothy Miles Rawson, Luke S P Moore, Benjamin Evans, Christofer Toumazou, Alison H Holmes, Pantelis Georgiou
BACKGROUND: Antimicrobial Resistance is threatening our ability to treat common infectious diseases and overuse of antimicrobials to treat human infections in hospitals is accelerating this process. Clinical Decision Support Systems (CDSSs) have been proven to enhance quality of care by promoting change in prescription practices through antimicrobial selection advice. However, bypassing an initial assessment to determine the existence of an underlying disease that justifies the need of antimicrobial therapy might lead to indiscriminate and often unnecessary prescriptions...
December 8, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/29214458/the-effects-of-uninvolved-side-epiphysiodesis-for-limb-length-equalization-in-children-with-unilateral-cerebral-palsy-clinical-evaluation-with-the-edinburgh-visual-gait-score
#6
Marco Corradin, Roberto Schiavon, Andrea Borgo, Jacques Deslandes, Antonella Cersosimo, Federico Canavese
PURPOSE: Hemiplegic cerebral palsy patient may present a shorten leg on the hemiplegic side that afflicts negatively the kinematic of the uninvolved limb. Thus, the aim of this study was to investigate the modification of gait kinematic after epiphysiodesis for limb equalization and secondary to verify the prediction of correction. METHODS: Skeletally immature hemiplegic patients with a minimum limb leg discrepancy (LLD) of 2.5 cm were treated with epiphysiodesis of the unaffected knee and clinically evaluated with Edinburgh visual gait score (EVGS)...
December 6, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29213105/preoperative-prostate-health-index-predicts-poor-pathologic-outcomes-of-radical-prostatectomy-in-patients-with-biopsy-detected-low-risk-patients-prostate-cancer-results-from-a-chinese-prospective-cohort
#7
Bo Tang, Cheng-Tao Han, Xiao-Lin Lu, Fang-Ning Wan, Cui-Zhu Zhang, Yao Zhu, Ding-Wei Ye
OBJECTIVE: To determine the performance of the prostate health index (PHI) in predicting pathologic outcomes of radical prostatectomy (RP) in Chinese patients with low-risk prostate cancer (PCa). METHODS: Of all consecutive patients who underwent RP in one tertiary center from September 2013 to January 2017, we prospectively examined the data of 140 patients with low-risk PCa based on the Prostate Cancer Research International: Active Surveillance (PRIAS) criteria...
December 6, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29212699/rapid-microarray-based-detection-of-rifampicin-isoniazid-and-fluoroquinolone-resistance-in-mycobacterium-tuberculosis-using-a-single-cartridge
#8
Juliane Havlicek, Beatrice Dachsel, Peter Slickers, Sönke Andres, Patrick Beckert, Silke Feuerriegel, Stefan Niemann, Matthias Merker, Ines Labugger
Rapid and robust identification of mutations in Mycobacterium tuberculosis complex (MTBC) strains mediating multidrug and extensively drug-resistant (M/XDR) phenotypes is crucial to combat the MDR tuberculosis (TB) epidemic. Currently available molecular TB drug susceptibility tests are either restricted to single targets/drugs (i.e. Xpert MTB/RIF) or aid the risk of cross-contaminations due to the design limitations of the open platform (i.e. line probe assays).With a good understanding of the technical and commercial boundaries we designed a test cartridge with an introduction of dried reagents, based on an oligonucleotide array, which has the ability to identify MTBC strains resistant to isoniazid, rifampicin and the fluoroquinolones...
December 6, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29212522/a-systematic-review-of-neonatal-treatment-intensity-scores-and-their-potential-application-in-low-resource-setting-hospitals-for-predicting-mortality-morbidity-and-estimating-resource-use
#9
Jalemba Aluvaala, Gary S Collins, Michuki Maina, James A Berkley, Mike English
BACKGROUND: Treatment intensity scores can predict mortality and estimate resource use. They may therefore be of interest for essential neonatal care in low resource settings where neonatal mortality remains high. We sought to systematically review neonatal treatment intensity scores to (1) assess the level of evidence on predictive performance in predicting clinical outcomes and estimating resource utilisation and (2) assess the applicability of the identified models to decision making for neonatal care in low resource settings...
December 7, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29211800/diagnostic-test-strategies-in-children-at-increased-risk-of-inflammatory-bowel-disease-in-primary-care
#10
Gea A Holtman, Yvonne Lisman-van Leeuwen, Boudewijn J Kollen, Obbe F Norbruis, Johanna C Escher, Laurence C Walhout, Angelika Kindermann, Yolanda B de Rijke, Patrick F van Rheenen, Marjolein Y Berger
BACKGROUND: In children with symptoms suggestive of inflammatory bowel disease (IBD) who present in primary care, the optimal test strategy for identifying those who require specialist care is unclear. We evaluated the following three test strategies to determine which was optimal for referring children with suspected IBD to specialist care: 1) alarm symptoms alone, 2) alarm symptoms plus c-reactive protein, and 3) alarm symptoms plus fecal calprotectin. METHODS: A prospective cohort study was conducted, including children with chronic gastrointestinal symptoms referred to pediatric gastroenterology...
2017: PloS One
https://www.readbyqxmd.com/read/29209139/bayes-theorem-the-roc-diagram-and-reference-values-definition-and-use-in-clinical-diagnosis
#11
REVIEW
Anders Kallner
Medicine is diagnosis, treatment and care. To diagnose is to consider the probability of the cause of discomfort experienced by the patient. The physician may face many options and all decisions are liable to uncertainty to some extent. The rational action is to perform selected tests and thereby increase the pre-test probability to reach a superior post-test probability of a particular option. To draw the right conclusions from a test, certain background information about the performance of the test is necessary...
February 15, 2018: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://www.readbyqxmd.com/read/29208919/robust-method-for-identification-of-prognostic-gene-signatures-from-gene-expression-profiles
#12
Woogwang Sim, Jungsul Lee, Chulhee Choi
In the last decade, many attempts have been made to use gene expression profiles to identify prognostic genes for various types of cancer. Previous studies evaluating the prognostic value of genes suffered by failing to solve the critical problem of classifying patients into different risk groups based on specific gene expression threshold levels. Here, we present a novel method, called iterative patient partitioning (IPP), which was inspired by the receiver operating characteristic (ROC) curve, is based on the log-rank test and overcomes the threshold decision problem...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29205428/power-doppler-ultrasonography-and-shear-wave-elastography-as-complementary-imaging-methods-for-suspected-local-breast-cancer-recurrence
#13
Rodrigo Menezes Jales, Maira Teixeira Dória, Kátia Piton Serra, Mila Meneguelli Miranda, Carlos Alberto Menossi, Klaus Schumacher, Luis Otávio Sarian
OBJECTIVES: To prospectively investigate the diagnostic accuracy and clinical consequences of power Doppler morphologic criteria and shear wave elastography (SWE) as complementary imaging methods for evaluation of suspected local breast cancer recurrence in the ipsilateral breast or chest wall. METHODS: Thirty-two breast masses with a suspicion of local breast cancer recurrence on B-mode ultrasonography underwent complementary power Doppler and SWE evaluations. Power Doppler morphologic criteria were classified as avascular, hypovascular, or hypervascular...
December 4, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29198576/influencing-factors-of-domestic-waste-characteristics-in-rural-areas-of-developing-countries
#14
REVIEW
Zhiyong Han, Yong Liu, Min Zhong, Guozhong Shi, Qibin Li, Dan Zeng, Yu Zhang, Yongqiang Fei, Yanhua Xie
Waste management in rural areas has become a major challenge for governments of developing countries. The success of waste management decisions directly lies in the accuracy and reliability of the data on which choices are based; many factors influence these data. Here, we examined the factors influencing domestic waste in rural areas of developing countries (RADIC), using both field surveys and by reviewing previous literature. The social factors included population, education and culture. There was a positive linear relationship between waste generation amount and population size (R2 = 0...
November 29, 2017: Waste Management
https://www.readbyqxmd.com/read/29198096/prognostic-factors-and-decision-tree-for-long-term-survival-in-metastatic-uveal-melanoma
#15
Daniel Lorenzo, María Ochoa, Josep Maria Piulats, Cristina Gutiérrez, Luis Arias, Jaum Català, María Grau, Judith Peñafiel, Estefanía Cobos, Pere Garcia-Bru, Marcos Javier Rubio, Noel Padrón-Pérez, Bruno Dias, Joan Pera, Josep Maria Caminal
Purpose: The purpose of this study was to demonstrate the existence of a bimodal survival pattern in metastatic uveal melanoma. Secondary aims were to identify the characteristics and prognostic factors associated with long-term survival and to develop a clinical decision tree. Materials and Methods: The medical records of 99 metastatic uveal melanoma patients were retrospectively reviewed. Patients were classified as either short (≤ 12 months) or long-term survivors (> 12 months) based on a graphical interpretation of the survival curve after diagnosis of the first metastatic lesion...
December 4, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29197965/progress-of-statistical-analysis-in-biomedical-research-through-the-historical-review-of-the-development-of-the-framingham-score
#16
Aleksandra Ignjatović, Miodrag Stojanović, Zoran Milošević, Marija Anđelković Apostolović
BACKGROUND: The interest in developing risk models in medicine not only is appealing, but also associated with many obstacles in different aspects of predictive model development. Initially, the association of biomarkers or the association of more markers with the specific outcome was proven by statistical significance, but novel and demanding questions required the development of new and more complex statistical techniques. METHODS: Progress of statistical analysis in biomedical research can be observed the best through the history of the Framingham study and development of the Framingham score...
December 2, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29194703/development-and-psychometric-evaluation-of-a-rapid-intimate-partner-violence-perpetration-screening-tool
#17
Cory A Crane, Samara L Rice, Robert C Schlauch
Current methods of identifying intimate partner violence (IPV) perpetration rely upon lengthy screening instruments, partner injury, and legal involvement. There exist no viable, brief screening tools to facilitate the rapid and early identification of IPV perpetration. The development of a brief IPV screening tool would reduce participant burden and compensation in research as well as aid in self-identification and appropriate consultation for treatment. Three samples were recruited and administered an IPV assessment measure...
November 30, 2017: Aggressive Behavior
https://www.readbyqxmd.com/read/29193683/prognostic-value-of-urinary-11-dehydro-thromboxane-b2-for-mortality-a-cohort-study-of-stable-coronary-artery-disease-patients-treated-with-aspirin
#18
Anupama Vasudevan, Kristen M Tecson, Jeanna Bennett-Firmin, Teodoro Bottiglieri, Luis R Lopez, Margarita Peterson, Mohanakrishnan Sathyamoorthy, Raphael Schiffmann, Jeffrey M Schussler, Caren Swift, Carlos E Velasco, Peter A McCullough
AIM: There is a variable cardiovascular risk reduction attributable to aspirin because of individual differences in the suppression of thromboxane A2 and its downstream metabolite 11-dehydro-thromboxane B2 (11dhTxB2 ). The aim of this study is to evaluate the optimal cut point of urinary 11dhTxB2 for the risk of mortality in aspirin-treated coronary artery disease (CAD) patients. METHODS AND RESULTS: This was a prospective cohort study including stable CAD patients who visited the Baylor Heart and Vascular Hospital in Dallas or the Texas Heart Hospital Baylor Plano, TX between 2010 and 2013...
November 29, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29191094/potential-of-predictive-computer-models-for-preoperative-patient-selection-to-enhance-overall-quality-adjusted-life-years-gained-at-2-year-follow-up-a-simulation-in-234-patients-with-adult-spinal-deformity
#19
Taemin Oh, Justin K Scheer, Justin S Smith, Richard Hostin, Chessie Robinson, Jeffrey L Gum, Frank Schwab, Robert A Hart, Virginie Lafage, Douglas C Burton, Shay Bess, Themistocles Protopsaltis, Eric O Klineberg, Christopher I Shaffrey, Christopher P Ames
OBJECTIVE Patients with adult spinal deformity (ASD) experience significant quality of life improvements after surgery. Treatment, however, is expensive and complication rates are high. Predictive analytics has the potential to use many variables to make accurate predictions in large data sets. A validated minimum clinically important difference (MCID) model has the potential to assist in patient selection, thereby improving outcomes and, potentially, cost-effectiveness. METHODS The present study was a retrospective analysis of a multiinstitutional database of patients with ASD...
December 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/29186185/cost-effectiveness-of-different-strategies-for-diagnosis-of-uncomplicated-urinary-tract-infections-in-women-presenting-in-primary-care
#20
Judith E Bosmans, Veerle M H Coupé, Bart J Knottnerus, Suzanne E Geerlings, Eric P Moll van Charante, Gerben Ter Riet
BACKGROUND: Uncomplicated Urinary Tract Infections (UTIs) are common in primary care resulting in substantial costs. Since antimicrobial resistance against antibiotics for UTIs is rising, accurate diagnosis is needed in settings with low rates of multidrug-resistant bacteria. OBJECTIVE: To compare the cost-effectiveness of different strategies to diagnose UTIs in women who contacted their general practitioner (GP) with painful and/or frequent micturition between 2006 and 2008 in and around Amsterdam, The Netherlands...
2017: PloS One
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