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https://www.readbyqxmd.com/read/29055166/drug-monitoring-of-sunitinib-in-patients-with-advanced-solid-tumors-a-monocentric-observational-french-study
#1
Luc Cabel, Benoit Blanchet, Audrey Thomas-Schoemann, Olivier Huillard, Audrey Bellesoeur, Anatole Cessot, Julie Giroux, Pascaline Boudou-Rouquette, Romain Coriat, Michel Vidal, Nathaniel E B Saidu, Lisa Golmard, Jérome Alexandre, Francois Goldwasser
Therapeutic drug monitoring (TDM) could be helpful in oral targeted therapies. Data are sparse to evaluate its impact on treatment management. This study aimed to determine a threshold value of plasma drug exposure associated with the occurrence of grade 3-4 toxicity, then the potential impact of TDM on clinical decision. Consecutive outpatients treated with sunitinib were prospectively monitored between days 21-28 of the first cycle, then monthly until disease progression. At each consultation, the composite AUCƬ,ss (sunitinib + active metabolite SU12662) was assayed...
October 21, 2017: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/29054778/validation-of-prognostic-models-to-predict-early-mortality-in-spontaneous-intracerebral-hemorrhage-a-cross-sectional-evaluation-of-a-singapore-stroke-database
#2
Julian Xinguang Han, Angela An Qi See, Nicolas Kon Kam King
OBJECTIVE: Numerous scores have been developed for prognostication of outcomes in intracerebral hemorrhage (ICH). Prediction models must be validated internally and externally before they are considered widely applicable. We aim to independently externally validate and compare three prediction models (ICH score, ICH grading scale (ICH-GS) and simplified ICH (sICH)) in our population, which has not been previously done. METHODS: We reviewed 1338 patients with spontaneous ICH consecutively admitted to the National Neuroscience Institute (NNI), Singapore, between January 2009 and November 2013...
October 17, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29054250/using-anchors-from-free-text-in-electronic-health-records-to-diagnose-postoperative-delirium
#3
Karl Øyvind Mikalsen, Cristina Soguero-Ruiz, Kasper Jensen, Kristian Hindberg, Mads Gran, Arthur Revhaug, Rolv-Ole Lindsetmo, Stein Olav Skrøvseth, Fred Godtliebsen, Robert Jenssen
OBJECTIVES: Postoperative delirium is a common complication after major surgery among the elderly. Despite its potentially serious consequences, the complication often goes undetected and undiagnosed. In order to provide diagnosis support one could potentially exploit the information hidden in free text documents from electronic health records using data-driven clinical decision support tools. However, these tools depend on labeled training data and can be both time consuming and expensive to create...
December 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29054189/development-of-a-diagnosis-model-for-coronary-artery-disease
#4
Hongzeng Xu, Zhiying Duan, Chi Miao, Song Geng, Yuanzhe Jin
BACKGROUND: The purpose of this study was to develop a coronary artery disease (CAD) prediction model that optimally estimates the pre-test probability of CAD for patients suspected of CAD. METHODS AND RESULTS: This retrospective, multi-centre study included 7360 consecutive patients (4678 men, 57.87±11.42 years old; 2682 women, 61.60±9.58 years old) who underwent coronary angiography for evaluation of CAD. A prediction model was fitted for diagnosis of CAD with the help of eight significant risk factors including sex, age, smoking status, diabetes, hypertension, dyslipidaemia, serum creatinine and angina...
September 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/29052956/meta-analysis-of-full-roc-curves-using-bivariate-time-to-event-models-for-interval-censored-data
#5
Annika Hoyer, Stefan Hirt, Oliver Kuss
Systematic reviews and meta-analyses are the cornerstones of evidence based medicine and inform treatment, diagnosis, or prevention of individual patients as well as policy decisions in health care. Statistical methods for the meta-analysis of intervention studies are well established today. Meta-analysis for diagnostic accuracy trials has also been a vivid research area in recent years which is especially due to the increased complexity of their bivariate outcome of sensitivity and specificity. The situation is even more challenging when single studies report a full ROC curve with several pairs of sensitivity and specificity, each pair for a different threshold...
October 20, 2017: Research Synthesis Methods
https://www.readbyqxmd.com/read/29051222/development-and-validation-of-a-predictive-model-for-functional-outcome-after-stroke-rehabilitation-the-maugeri-model
#6
Domenico Scrutinio, Bernardo Lanzillo, Pietro Guida, Filippo Mastropasqua, Vincenzo Monitillo, Monica Pusineri, Roberto Formica, Giovanna Russo, Caterina Guarnaschelli, Chiara Ferretti, Gianluigi Calabrese
BACKGROUND AND PURPOSE: Prediction of outcome after stroke rehabilitation may help clinicians in decision-making and planning rehabilitation care. We developed and validated a predictive tool to estimate the probability of achieving improvement in physical functioning (model 1) and a level of independence requiring no more than supervision (model 2) after stroke rehabilitation. METHODS: The models were derived from 717 patients admitted for stroke rehabilitation...
October 19, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29049205/using-a-novel-t-lymph-node-ratio-model-to-evaluate-the-prognosis-of-nonmetastatic-breast-cancer-patients-who-received-preoperative-radiotherapy-followed-by-mastectomy-an-observational-study
#7
Yang Wang, Yuanyuan Zhao, Song Liu, Weifang Tang, Hong Gao, Xucai Zheng, Shikai Hong, Shengying Wang
We aimed to investigate the prognostic value of postpathological characters in nonmetastatic breast cancer (NMBC) patients who received preoperative radiotherapy (PRT) followed by mastectomy (MAST).We conducted retrospective analyses using the data collected from the Surveillance, Epidemiology, and End Results program of the National Cancer Institute. Univariate and multivariate analyses were performed to identify prognostic factors. Disease-specific survival was calculated by the Kaplan-Meier curve and validated by log rank test...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29048801/-determination-of-thyreostats-in-bovine-urine-using-ultra-high-performance-liquid-chromatography-tandem-mass-spectrometry
#8
Rodziewicz Lech, MasŁOwiecka Jolanta, Sadowska Anna, Car Halina
Five thyreostats (TSs), namely tapazole, thiouracil, methylthiouracil, propylthiouracil, and phenylthiouracil, were determined in bovine urine using ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) in positive electrospray ionization mode. Extraction and clean-up were achieved using a ChemElut cartridge with tert-butyl methyl ether, without a derivatization step. Separation was achieved on an Acquity UPLC SS T3 column. The mobile phase was acetonitrile and water containing 0...
October 8, 2017: Se Pu, Chinese Journal of Chromatography
https://www.readbyqxmd.com/read/29048710/correlations-among-ultrasound-guided-diffuse-optical-tomography-microvessel-density-and-breast-cancer-prognosis
#9
Sihua Niu, Qingli Zhu, Yuxin Jiang, Jiaan Zhu, Mengsu Xiao, Shanshan You, Weixun Zhou, Yu Xiao
OBJECTIVES: To investigate the correlation among ultrasound-guided diffuse optical tomography (DOT), microvessel density, and breast cancer prognosis. METHODS: Before surgery, the total hemoglobin (Hb) concentrations of 184 female patients with breast cancer with only a single lesion were measured. During follow-up, 23 patients had recurrence or metastatic disease after surgery. Among these patients, 18 with recurrence or metastatic disease within 3 years after surgery were paired with 18 patients without recurrence or metastatic disease...
October 19, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29047033/characterization-of-pulmonary-nodules-based-on-features-of-margin-sharpness-and-texture
#10
José Raniery Ferreira, Marcelo Costa Oliveira, Paulo Mazzoncini de Azevedo-Marques
Lung cancer is the leading cause of cancer-related deaths in the world, and one of its manifestations occurs with the appearance of pulmonary nodules. The classification of pulmonary nodules may be a complex task to specialists due to temporal, subjective, and qualitative aspects. Therefore, it is important to integrate computational tools to the early pulmonary nodule classification process, since they have the potential to characterize objectively and quantitatively the lesions. In this context, the goal of this work is to perform the classification of pulmonary nodules based on image features of texture and margin sharpness...
October 18, 2017: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/29046647/east-london-modified-broset-as-decision-making-tool-to-predict-seclusion-in-psychiatric-intensive-care-units
#11
Felice Loi, Karl Marlowe
Seclusion is a last resort intervention for management of aggressive behavior in psychiatric settings. There is no current objective and practical decision-making instrument for seclusion use on psychiatric wards. Our aim was to test the predictive and discriminatory characteristics of the East London Modified-Broset (ELMB), to delineate its decision-making profile for seclusion of adult psychiatric patients, and second to benchmark it against the psychometric properties of the Broset Violence Checklist (BVC)...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29046111/eeg-classification-with-a-sequential-decision-making-method-in-motor-imagery-bci
#12
Rong Liu, Yongxuan Wang, Geoffrey I Newman, Nitish V Thakor, Sarah Ying
To develop subject-specific classifier to recognize mental states fast and reliably is an important issue in brain-computer interfaces (BCI), particularly in practical real-time applications such as wheelchair or neuroprosthetic control. In this paper, a sequential decision-making strategy is explored in conjunction with an optimal wavelet analysis for EEG classification. The subject-specific wavelet parameters based on a grid-search method were first developed to determine evidence accumulative curve for the sequential classifier...
September 7, 2017: International Journal of Neural Systems
https://www.readbyqxmd.com/read/29045700/prediction-model-of-critical-weight-loss-in-cancer-patients-during-particle-therapy
#13
Zhihong Zhang, Y Zhu, Lijuan Zhang, Ziying Wang, Hongwei Wan
Background and purpose: The objective of this study is to investigate the predictors of critical weight loss in cancer patients receiving particle therapy, and build a prediction model based on its predictive factors. Materials and methods: Patients receiving particle therapy were enroled between June 2015 and June 2016. Body weight was measured at the start and end of particle therapy. Association between critical weight loss (defined as >5%) during particle therapy and patients' demographic, clinical characteristic, pre-therapeutic nutrition risk screening (NRS 2002) and BMI were evaluated by logistic regression and decision tree analysis...
October 17, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29044908/tumor-radiomic-heterogeneity-multiparametric-functional-imaging-to-characterize-variability-and-predict-response-following-cervical-cancer-radiation-therapy
#14
Stephen R Bowen, William T C Yuh, Daniel S Hippe, Wei Wu, Savannah C Partridge, Saba Elias, Guang Jia, Zhibin Huang, George A Sandison, Dennis Nelson, Michael V Knopp, Simon S Lo, Paul E Kinahan, Nina A Mayr
BACKGROUND: Robust approaches to quantify tumor heterogeneity are needed to provide early decision support for precise individualized therapy. PURPOSE: To conduct a technical exploration of longitudinal changes in tumor heterogeneity patterns on dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI), diffusion-weighted imaging (DWI) and FDG positron emission tomography / computed tomography (PET/CT), and their association to radiation therapy (RT) response in cervical cancer...
October 16, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29040007/probing-birth-order-effects-on-narrow-traits-using-specification-curve-analysis
#15
Julia M Rohrer, Boris Egloff, Stefan C Schmukle
The idea that birth-order position has a lasting impact on personality has been discussed for the past 100 years. Recent large-scale studies have indicated that birth-order effects on the Big Five personality traits are negligible. In the current study, we examined a variety of more narrow personality traits in a large representative sample ( n = 6,500-10,500 in between-family analyses; n = 900-1,200 in within-family analyses). We used specification-curve analysis to assess evidence for birth-order effects across a range of models implementing defensible yet arbitrary analytical decisions (e...
October 1, 2017: Psychological Science
https://www.readbyqxmd.com/read/29037174/vitamin-d-supplementation-as-a-potential-cause-of-u-shaped-associations-between-vitamin-d-levels-and-negative-health-outcomes-a-decision-tree-analysis-for-risk-of-frailty
#16
Gotaro Kojima, Steve Iliffe, Marianne Tanabe
BACKGROUND: A recent controversy in vitamin D research is a "U-shaped association", with elevated disease risks at both high and low 25-hydroxyvitamin D (25 (OH) D) levels. METHODS: This is a cross-sectional study of 238 male nursing home veterans in Hawaii. Classification and regression tree (CART) analysis identified groups based on 25 (OH) D and vitamin D supplementation for frailty risk. Characteristics were examined and compared across the groups using logistic regression and receiver operating characteristic (ROC) curve analyses...
October 16, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/29036412/radiomic-subtyping-improves-disease-stratification-beyond-key-molecular-clinical-and-standard-imaging-characteristics-in-patients-with-glioblastoma
#17
Philipp Kickingereder, Ulf Neuberger, David Bonekamp, Paula L Piechotta, Michael Götz, Antje Wick, Martin Sill, Annekathrin Kratz, Russell T Shinohara, David T W Jones, Alexander Radbruch, John Muschelli, Andreas Unterberg, Jürgen Debus, Heinz-Peter Schlemmer, Christel Herold-Mende, Stefan Pfister, Andreas von Deimling, Wolfgang Wick, David Capper, Klaus H Maier-Hein, Martin Bendszus
Background: To analyze the potential of radiomics for disease stratification beyond key molecular, clinical and standard imaging features in patients with glioblastoma. Methods: Quantitative imaging features (n=1043) were extracted from the multiparametric MRI of 181 patients with newly-diagnosed glioblastoma prior to standard-of-care treatment (allocated to a discovery and validation set, 2:1 ratio). A subset of 386/1043 features were identified as reproducible (in an independent MRI-test-retest cohort) and selected for analysis...
September 28, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/29033559/pressure-injuries-in-elderly-with-acute-myocardial-infarction
#18
Klara Komici, Dino F Vitale, Dario Leosco, Angela Mancini, Graziamaria Corbi, Leonardo Bencivenga, Alessandro Mezzani, Bruno Trimarco, Carmine Morisco, Nicola Ferrara, Giuseppe Rengo
OBJECTIVES: To assess pressure injury (PI) incidence among patients hospitalized for acute myocardial infarction (AMI) in an intensive coronary care unit (ICCU) and to detect the impact of specific risk factors on the development of PI in this clinical setting. PATIENTS AND METHODS: Prospective cohort study in ICCU setting. Patients admitted for AMI: patients mean age 67.5±11.5 years (n=165). Norton Scale, Mini Nutritional Assessment (MNA), demographic, clinical and biochemical data collected at the time of ICCU admission have been tested in a logistic model to assess the odds ratios (ORs) of PI risk development...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29031415/usefulness-of-the-crt-score-for-shared-decision-making-in-cardiac-resynchronization-therapy-in-patients-with-a-left-ventricular-ejection-fraction-of-%C3%A2-35
#19
Ulas Höke, Bart Mertens, Mand J H Khidir, Martin J Schalij, Jeroen J Bax, Victoria Delgado, Nina Ajmone Marsan
Individualized estimation of prognosis after cardiac resynchronization therapy (CRT) remains challenging. Our aim was to develop a multiparametric prognostic risk score (CRT-SCORE) that could be used for patient-specific clinical shared decision making about CRT implantation. The CRT-SCORE was derived from an ongoing CRT registry, including 1,053 consecutive patients (age 67 ± 10 years, 76% male). Using preimplantation variables, 100 multiple imputed datasets were generated for model calibration. Based on multivariate Cox regression models, cross-validated linear prognostic scores were calculated, as well as survival fractions at 1 and 5 years...
August 30, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29030711/the-learning-curve-in-short-stem-tha-influence-of-the-surgeon-s-experience-on-intraoperative-adjustments-due-to-intraoperative-radiography
#20
Lennard Loweg, Karl Philipp Kutzner, Matthias Trost, Marlene Hechtner, Philipp Drees, Joachim Pfeil, Michael Schneider
INTRODUCTION: Short-stem THA has become increasingly popular over the last decade. However, implantation technique differs from conventional THA and thus possibly involves a distinct learning curve. The purpose of this study was to evaluate the value of intraoperative radiography and the influence of the surgeon's experience on intraoperative adjustments in short-stem THA. METHODS: A total of 287 consecutive short-stem THAs, operated by a total of 24 senior consultants, consultants and residents in training, were prospectively included...
October 13, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
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