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https://www.readbyqxmd.com/read/29908280/lncrna-uca1-sponges-mir-26a-to-regulate-the-migration-and-proliferation-of-vascular-smooth-muscle-cells
#1
Shigang Tian, Yuan Yuan, Zhuo Li, Ming Gao, Ying Lu, Haiying Gao
BACKGROUND: Recent studies have shown that the long non-coding RNA urothelial carcinoma-associated (UCA1) plays a key role in cardiovascular injury. However, the potential biological role of UCA1 in progression of atherosclerosis (AS) remains unclear. The aim of the present study is to identify the regulation of lncRNA UCA1 on atherosclerosis-related vascular dysfunction via miR-26a targeting phosphatase and tensin homolog (PTEN), and investigate the underlying mechanisms in the development of atherosclerosis...
June 13, 2018: Gene
https://www.readbyqxmd.com/read/29907363/critical-roles-of-inflammation-in-atherosclerosis
#2
REVIEW
Junji Moriya
There is accumulating evidence that vascular inflammation plays critical roles in pathophysiology of atherosclerosis. It is widely accepted that both innate and adaptive immune responses are important for initiation and progression of atherosclerosis, which mainly consist of monocytes, macrophages, neutrophils, T lymphocytes, and B lymphocytes. Moreover, inflammatory biomarkers such as high-sensitivity C-reactive protein and interleukin-6 are known to predict future cardiovascular events, as well as conventional low-density or high-density lipoprotein cholesterol...
June 12, 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29907101/cardiovascular-disease-lifestyle-risk-factors-in-people-with-psychosis-a-cross-sectional-study
#3
Doreen Mucheru, Mary-Claire Hanlon, Linda E Campbell, Mark McEvoy, Lesley MacDonald-Wicks
BACKGROUND: People with psychosis die on average 25 years earlier than those in the general population, with cardiovascular disease (CVD) contributing to much of the excess mortality. This cross-sectional study aimed to identify the relationship between lifestyle risk factors for CVD - poor nutrition, smoking and low physical activity levels - and dyslipidaemia, hypertension and hyperglycaemia while controlling for potential confounders in 1825 people from the Survey of High Impact Psychosis (SHIP) in Australia...
June 15, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29906479/evaluating-several-biomarkers-as-predictors-of-aortic-stiffness-in-young-and-older-africans-not-consuming-alcohol-based-on-self-report
#4
Melissa Maritz, Carla Mt Fourie, Johannes M VAN Rooyen, Aletta E Schutte
AIMS: Black populations from sub-Saharan Africa have a high prevalence of cardiovascular disease, which places significant strain on public health systems. Aortic stiffness is a prominent risk factor for cardiovascular disease development. We reported earlier that excessive alcohol use predicts aortic stiffness. However, we require a better understanding of other biomarkers involved in stiffness development, beyond alcohol use. Therefore, we determined which biomarkers (metabolic, inflammatory, endothelial activation and oxidative stress) relate to aortic stiffness in young and older black South Africans, self-reporting no alcohol-use...
June 12, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29906227/blood-pressure-predicts-endothelial-function-and-the-effects-of-ethinyl-estradiol-exposure-in-young-women
#5
Tessa E Adler, Charlotte W Usselman, Akira Takamata, Nina S Stachenfeld
Hypertension, obesity, and endothelial function predict cardiovascular disease in women and these factors are interrelated. We hypothesized that hypertension and obesity are associated with endothelial dysfunction in young women, and that short-term ethinyl estradiol exposure mitigates this dysfunction. We examined flow-mediated dilation responses before and during 7 days of oral ethinyl estradiol (30 µg/day) in 19 women (25 {plus minus} 5, 18-35 yrs). We divided our sample into two groups based on two criteria: blood pressure and obesity...
June 15, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29905827/predictors-of-residual-tricuspid-regurgitation-after-percutaneous-closure-of-atrial-septal-defect
#6
Martina Nassif, Frank van der Kley, Mohammad Abdelghani, Deborah N Kalkman, Rianne H A C M de Bruin-Bon, Berto J Bouma, Martin J Schalij, David R Koolbergen, Jan G P Tijssen, Barbara J M Mulder, Robbert J de Winter
Aims: Functional tricuspid regurgitation (TR) associated with atrial septal defects (ASDs) is frequently present due to right-sided volume-overload. Tricuspid valve (TV) repair is often considered in candidates for surgical ASD closure, and percutaneous TV repair is currently under clinical investigation. In this study, we develop a prediction model to identify patients with residual moderate/severe TR after percutaneous ASD closure. Methods and results: In this observational study, 172 adult patients (26% male, age 49 ± 17 years) with successful percutaneous ASD closure had pre- and post-procedural echocardiography...
June 13, 2018: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29905470/ultrasensitive-plasmonic-biosensors-for-real-time-parallel-detection-of-alpha-l-fucosidase-and-cardiac-troponin-i-in-whole-human-blood
#7
Xu Han, Hossein Shokri Kojori, Roger M Leblanc, Sung Jin Kim
Cancers and many other diseases, such as hepatocellular carcinoma (HCC) and cardiovascular diseases (CVD), have threatened human lives for centuries. Therefore, a novel technique for such disease prediction, therefore, is in an urgent demand for timely treatment. Biomarkers - alpha-L-fucosidase (AFU) for HCC and cardiac troponin I (cTnI) for CVD - have proven to be essential in the role of disease detection. Herein, we report on an ultrasensitive plasmonic biosensor that converts plasmonic absorption to electrical current in order to detect AFU and cTnI using whole human blood in a real-time and parallel fashion...
June 15, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29904123/response-inhibition-on-the-stop-signal-task-improves-during-cardiac-contraction
#8
Charlotte L Rae, Vanessa E Botan, Cassandra D Gould van Praag, Aleksandra M Herman, Jasmina A K Nyyssönen, David R Watson, Theodora Duka, Sarah N Garfinkel, Hugo D Critchley
Motor actions can be facilitated or hindered by psychophysiological states of readiness, to guide rapid adaptive action. Cardiovascular arousal is communicated by cardiac signals conveying the timing and strength of individual heartbeats. Here, we tested how these interoceptive signals facilitate control of motor impulsivity. Participants performed a stop signal task, in which stop cues were delivered at different time points within the cardiac cycle: at systole when the heart contracts (T-wave peak, approximately 300 ms following the R-wave), or at diastole between heartbeats (R-wave peak)...
June 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29903731/plasma-ceramides-a-novel-predictor-of-major-adverse-cardiovascular-events-after-coronary-angiography
#9
Jeffrey W Meeusen, Leslie J Donato, Sandra C Bryant, Linnea M Baudhuin, Peter B Berger, Allan S Jaffe
OBJECTIVE: Ceramides are sphingolipids involved with cellular signaling. Synthesis of ceramides occurs in all tissues. Ceramides accumulate within tissues and the blood plasma during metabolic dysfunction, dyslipidemia, and inflammation. Elevations of ceramides are predictive of cardiovascular mortality. We sought to verify the utility of plasma concentrations of 4 ceramides: N-palmitoyl-sphingosine [Cer(16:0)], N-stearoyl-sphingosine [Cer(18:0)], N-nervonoyl-sphingosine [Cer(24:1)], and N-lignoceroyl-sphingosine [Cer(24:0)] in predicting major adverse cardiovascular events in a diverse patient population referred for coronary angiography...
June 14, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29903515/the-nonalcoholic-fatty-liver-disease-nafld-fibrosis-score-cardiovascular-risk-stratification-and-a-strategy-for-secondary-prevention-with-ezetimibe
#10
Tracey G Simon, Kathleen E Corey, Christopher P Cannon, Michael Blazing, Jeong-Gun Park, Michelle L O'Donoghue, Raymond T Chung, Robert P Giugliano
OBJECTIVE: The nonalcoholic fatty liver disease fibrosis score (NFS) is comprised of unique metabolic risk indicators that may accurately predict residual cardiovascular (CV) risk in patients with established coronary disease and metabolic dysfunction. METHODS: We applied the NFS prospectively to 14,819 post-ACS patients randomized to ezetimibe/simvastatin (E/S) or placebo/simvastatin (P/S), in the IMPROVE-IT trial, using validated NFS cutoffs. The primary endpoint included CV death, myocardial infarction, unstable angina, revascularization or stroke...
May 26, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29903478/non-invasive-detection-of-coronary-artery-disease-in-high-risk-patients-based-on-the-stenosis-prediction-of-separate-coronary-arteries
#11
Roohallah Alizadehsani, Mohammad Javad Hosseini, Abbas Khosravi, Fahime Khozeimeh, Mohamad Roshanzamir, Nizal Sarrafzadegan, Saeid Nahavandi
BACKGROUND AND OBJECTIVE: Cardiovascular diseases are an extremely widespread sickness and account for 17 million deaths in the world per annum. Coronary artery disease (CAD) is one of such diseases with an annual mortality rate of about 7 million. Thus, early diagnosis of CAD is of vital importance. Angiography is currently the modality of choice for the detection of CAD. However, its complications and costs have prompted researchers to seek alternative methods via machine learning algorithms...
August 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29903472/is-chocolate-consumption-associated-with-health-outcomes-an-umbrella-review-of-systematic-reviews-and-meta-analyses
#12
Nicola Veronese, Jacopo Demurtas, Stefano Celotto, Maria Gabriella Caruso, Stefania Maggi, Francesco Bolzetta, Joseph Firth, Lee Smith, Patricia Schofield, Ai Koyanagi, Lin Yang, Marco Solmi, Brendon Stubbs
BACKGROUND & AIMS: The literature regarding the potential health benefits of chocolate consumption are unclear and the epidemiological credibility has not been systematically scrutinized, while the strength of the evidence is undetermined. We therefore aimed to map and grade the diverse health outcomes associated with chocolate consumption using an umbrella review of systematic reviews. METHODS: Umbrella review of systematic reviews of observational and intervention studies (randomized placebo-controlled trials, RCTs)...
June 1, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29902702/ankle-brachial-index-measured-by-oscillometry-is-predictive-for-cardiovascular-disease-and-premature-death-in-the-japanese-population-an-individual-participant-data-meta-analysis
#13
Toshiaki Ohkuma, Toshiharu Ninomiya, Hirofumi Tomiyama, Kazuomi Kario, Satoshi Hoshide, Yoshikuni Kita, Toyoshi Inoguchi, Yasutaka Maeda, Katsuhiko Kohara, Yasuharu Tabara, Motoyuki Nakamura, Takayoshi Ohkubo, Hirotaka Watada, Masanori Munakata, Mitsuru Ohishi, Norihisa Ito, Michinari Nakamura, Tetsuo Shoji, Charalambos Vlachopoulos, Victor Aboyans, Akira Yamashina
BACKGROUND AND AIMS: The ankle-brachial index (ABI) is a predictor of cardiovascular disease (CVD) and premature death. However, few studies on this marker are available in the general Asian populations. This study aimed to investigate the association between ABI measured with oscillometry and the risk of these outcomes. METHODS: We conducted an individual participant data meta-analysis in 10,679 community-dwelling Japanese individuals without a history of CVD. The primary outcome was a composite of CVD events and all-cause mortality...
May 31, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29902229/mir-146a-deficiency-in-hematopoietic-cells-is-not-involved-in-the-development-of-atherosclerosis
#14
Alberto Del Monte, Ana B Arroyo, María J Andrés-Manzano, Nuria García-Barberá, María S Caleprico, Vicente Vicente, Vanessa Roldán, Rocío González-Conejero, Constantino Martínez, Vicente Andrés
BACKGROUND: Atherosclerosis involves activation of the IRAK1/TRAF6/NF-κB inflammatory cascade, which is negatively regulated by miR146a. Previous studies showed that the TT genotype of rs2431697, located near the miR-146a gene, drives lower miR-146a transcription and predicts adverse cardiovascular events in anticoagulated atrial fibrillation patients. Moreover, systemic miR-146a administration protects mice from atherosclerosis. Here we evaluated the ability of miR-146a expression in the hematopoietic component to regulate atherosclerosis in low-density lipoprotein receptor-null mice (Ldlr-/-)...
2018: PloS One
https://www.readbyqxmd.com/read/29902218/assessment-of-the-clinical-efficacy-of-the-heart-spectrum-blood-pressure-monitor-for-diagnosis-of-atrial-fibrillation-an-unblinded-clinical-trial
#15
Wei-Fong Kao, Sen-Kuang Hou, Chun-Yao Huang, Chun-Chieh Chao, Chung-Chih Cheng, Yi-Jung Chen
Atrial fibrillation (AF) is the most common arrhythmia. The most common diagnostic method, 12-lead electrocardiogram (ECG), can record episodes of arrhythmia from which the type and severity can be determined. The Heart Spectrum Blood Pressure Monitor (P2; OSTAR Meditech Corp., New Taipei City, Taiwan) is used to measure cardiovascular pressure change with fast Fourier transform (FFT) analysis to obtain heart rate frequency variability and accurate blood pressure data. We compared the diagnostic efficacy of the Heart Spectrum Blood Pressure Monitor to a 12-lead ECG (gold standard) for patients with AF...
2018: PloS One
https://www.readbyqxmd.com/read/29901483/poor-oral-health-predicts-higher-10-year-cardiovascular-risk-a-propensity-score-matching-analysis
#16
Seon Young Hwang, Jae Lan Shim, Dayun Kang, Jungsoon Choi
BACKGROUND: Although the association between periodontitis and cardiovascular disease (CVD) has been reported, whether periodontitis and poor oral health behavior influence CVD risk remains unclear. OBJECTIVE: The aim of this study was to examine whether periodontal disease and poor oral health behavior predict 10-year general CVD risk using the Framingham Risk Score. METHODS: Patients older than 30 years with no CVD history (n = 8370) were selected using cross-sectional study data from the Korean National Health and Nutrition Examination Survey in 2013 and 2014...
June 12, 2018: Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/29901123/screening-genes-associated-with-elevated-neutrophil%C3%A2-to%C3%A2-lymphocyte-ratio-in-chronic-heart-failure
#17
Guoxing Wan, Lihua Ji, Wenbin Xia, Lan Cheng, Yonggang Zhang
Neutrophil‑to‑lymphocyte ratio (NLR) is commonly considered a useful prognostic index for many cardiovascular diseases; however, it has limited sensitivity and specificity. Factors associated with elevated NLR may aid in the prediction of prognosis with heart failure (HF) in combination with NLR. The present study sought to identify decisive factors associated with NLR in HF patients and investigate their association with elevated NLR. The gene expression profile for blood samples from 197 individuals with chronic heart failure (CHF), with corresponding hematological parameters and clinical data were obtained from the public database, GSE77343...
June 5, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29900795/evaluating-allostatic-load-a-new-approach-to-measuring-long-term-stress-in-wildlife
#18
Ashley N Edes, Barbara A Wolfe, Douglas E Crews
  Animal welfare, conservation, and stress assessment are all critical components of species survival. As organisms experience stressors, they accumulate physiologic dysregulation, leading to multiple negative health outcomes. This brief review suggests measuring the degree of stress-induced damage, known as allostatic load, and then using allostatic load to evaluate changes implemented to improve animal welfare and conservation efforts. Over the past two decades, human clinical research has developed multiple allostatic load indices constructed from composites of neuroendocrine, cardiovascular, metabolic, and immune biomarkers...
June 2018: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/29898850/prognosis-in-relation-to-high-sensitivity-cardiac-troponin-t-levels-in-patients-with-myocardial-infarction-and-non-obstructive-coronary-arteries
#19
Marcus Hjort, Bertil Lindahl, Tomasz Baron, Tomas Jernberg, Per Tornvall, Kai M Eggers
BACKGROUND: Myocardial infarction (MI) with non-obstructive coronary arteries (MINOCA) is a recently recognized condition where biomarkers and prognosis are less well studied than in MI with obstructive coronary artery disease (MI-CAD). We therefore aimed to investigate the one-year prognostic value of high-sensitivity cardiac troponin T (hs-cTnT) levels in MINOCA in comparison to MI-CAD. METHODS: In this registry-based cohort study, we used data from patients with a discharge diagnosis of MI, admitted between 2009 and 2013 to Swedish hospitals using the hs-cTnT assay...
June 2018: American Heart Journal
https://www.readbyqxmd.com/read/29898839/does-clinician-reported-lipid-guideline-adoption-translate-to-guideline-adherent-care-an-evaluation-of-the-patient-and-provider-assessment-of-lipid-management-palm-registry
#20
Angela Lowenstern, Shuang Li, Ann Marie Navar, Salim Virani, L Veronica Lee, Michael J Louie, Eric D Peterson, Tracy Y Wang
BACKGROUND: The 2013 American College of Cardiology (ACC)/American Heart Association (AHA) cholesterol guideline recommends statin treatment based on patients' predicted atherosclerotic cardiovascular disease (ASCVD) risk. Whether clinician-reported guideline adoption translates to implementation into practice is unknown. OBJECTIVES: We aimed to compare clinician lipid management in hypothetical scenarios versus observed practice. METHODS: The PALM Registry asked 774 clinicians how they would treat 4 hypothetical scenarios of primary prevention patients with: (1) diabetes; (2) high 10-year ASCVD risk (≥7...
June 2018: American Heart Journal
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