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https://www.readbyqxmd.com/read/29156422/syndecan-1-in-mechanosensing-of-nanotopological-cues-in-engineered-materials
#1
Victoria Le, Jason Lee, Somali Chaterji, Adrianne Spencer, Yen-Liang Liu, Peter Kim, Hsin-Chih Yeh, Deok-Ho Kim, Aaron B Baker
The cells of the vascular system are highly sensitive to biophysical cues from their local cellular microenvironment. To engineer improved materials for vascular devices and delivery of cell therapies, a key challenge is to understand the mechanisms that cells use to sense biophysical cues from their environment. Syndecans are heparan sulfate proteoglycans (HSPGs) that consist of a protein core modified with heparan sulfate glycosaminoglycan chains. Due to their presence on the cell surface and their interaction with cytoskeletal and focal adhesion associated molecules, cell surface proteoglycans are well poised to serve as mechanosensors of the cellular microenvironment...
November 9, 2017: Biomaterials
https://www.readbyqxmd.com/read/29153638/%C3%AE-1-anti-trypsin-improves-function-of-porcine-donor-lungs-during-ex-vivo-lung-perfusion
#2
Huiqing Lin, Manyin Chen, Feng Tian, Jussi Tikkanen, Lei Ding, Hei Yu Andrew Cheung, Daisuke Nakajima, Zhe Wang, Andrea Mariscal, David Hwang, Marcelo Cypel, Shaf Keshavjee, Mingyao Liu
BACKGROUND: Ex-vivo lung perfusion (EVLP), a technique for donor lung assessment, also represents a platform for donor lung repair and immunomodulation. α1-Anti-trypsin (A1AT), a medication used to treat emphysema in A1AT-deficient patients, has anti-inflammatory properties and has been shown to attenuate ischemia-reperfusion injury in rat and pig lung transplants. The objective of this study was to determine whether administration of A1AT during EVLP can improve donor lung quality after prolonged hypothermic preservation...
October 2, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29153055/routine-colonoscopy-diabetic-eye-care-mammogram-and-pap-smear-screening-in-vascular-surgery-patients
#3
Young Lee, Afsha Aurshina, Aaron J Lee, Israel M Ackerman, Michael Chait, Daniel Novak, Anil Hingorani, Enrico Ascher, Natalie Marks
Objective An increasing emphasis on preventive medicine has been supported by the recent reforms in United States health care system. Majority of the patients seen in vascular surgery clinics are elderly with more extensive medical comorbidities compared to the general population. Thus, these patients would be expected at higher risk for common malignant pathologies such as colon, breast and cervical cancer, and nonmalignant diseases such as diabetic retinopathy. This study looked at the screening compliance of vascular patients compared to data provided by Centers for Disease Control on the national and state levels...
January 1, 2017: Vascular
https://www.readbyqxmd.com/read/29152859/deletion-of-the-egf-receptor-in-vascular-smooth-muscle-cells-prevents-chronic-angiotensin-ii-induced-arterial-wall-stiffening-and-media-thickening
#4
Barbara Schreier, Mirja Hünerberg, Sigrid Mildenberger, Sindy Rabe, Daniel Bethmann, Claudia Wickenhauser, Michael Gekle
AIM: In vivo vascular smooth muscle cell (VSMC) EGF receptor (EGFR) contributes to acute angiotensin II (AII) effects on vascular tone and blood pressure. The ubiquitously expressed EGFR has been implicated in vascular remodeling preceding end-organ damage by pharmacological inhibition, and AII signaling in cultured vascular cells is partly EGFR dependent. However the role of VSMC-EGFR in vivo during AII-induced pathophysiological processes is not known. METHODS: The present study assesses the in vivo relevance of VSMC-EGFR during chronic AII challenge without further stressors, using a mouse model with inducible, VSMC-specific EGFR knock out (VSMC-EGFR-KO)...
November 20, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/29150946/lncrna-tcons_00034812-in-cell-proliferation-and-apoptosis-of-pulmonary-artery-smooth-muscle-cells-and-its-mechanism
#5
Yun Liu, Zengxian Sun, Jinquan Zhu, Bingxin Xiao, Jie Dong, Xiaomin Li
Long noncoding RNAs (lncRNAs) have been discovered to be playing important role in various biological processes. However, the contribution of lncRNAs to pulmonary artery hypertension (PAH) remains largely unknown. Pulmonary vascular remodeling is an important pathological feature of PAH, leading to increased vascular resistance and reduced compliance. Here, we investigated the biological role of lncRNAs in PAH. Differences in the lncRNAs and mRNAs between hypoxia PAH rats and normoxia rats were screened using microarray analysis...
November 18, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29150159/diagnostic-performance-of-pulmonary-capacitance-at-rest-and-during-exercise-in-idiopathic-pulmonary-arterial-hypertension
#6
Pankaj Jain, Sriram Rao, Peter Macdonald, Eugene Kotlyar, Andrew Jabbour, Christopher Hayward, Anne Keogh
BACKGROUND: Reliable markers of early disease are needed in pulmonary arterial hypertension (PAH). As measures of the contribution of abnormal vascular compliance to overall vascular resistance, resting and exercise pulmonary capacitance-defined as the stroke volume divided by the change in pulmonary pulse pressure-may be sensitive markers of early disease. METHODS: We examined all patients in our pulmonary hypertension database with idiopathic PAH, who had undergone rest and exercise right heart catheterisation in one sitting...
November 8, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29148140/haemodynamic-effects-of-an-acute-vasodilator-challenge-in-heart-failure-patients-with-reduced-ejection-fraction-and-different-forms-of-post-capillary-pulmonary-hypertension
#7
Stefano Ghio, Gabriele Crimi, Pier Luigi Temporelli, Egidio Traversi, Maria Teresa La Rovere, Antonia Cannito, Dario Vizza, Laura Scelsi, Claudia Raineri, Marco Guazzi, Luigi Oltrona Visconti
AIMS: The most recent European guidelines have proposed new definitions of pulmonary hypertension (PH) in left heart disease, to better approach the characteristics required to reflect the presence of pulmonary vascular disease. The purpose of this study was to assess whether different haemodynamic definitions of post-capillary PH imply a different reversibility of PH in response to acute vasodilator administration in heart failure patients with reduced ejection fraction and PH (HFrEF-PH)...
November 16, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29118115/computational-tools-for-clinical-support-a-multi-scale-compliant-model-for-haemodynamic-simulations-in-an-aortic-dissection-based-on-multi-modal-imaging-data
#8
Mirko Bonfanti, Stavroula Balabani, John P Greenwood, Sapna Puppala, Shervanthi Homer-Vanniasinkam, Vanessa Díaz-Zuccarini
Aortic dissection (AD) is a vascular condition with high morbidity and mortality rates. Computational fluid dynamics (CFD) can provide insight into the progression of AD and aid clinical decisions; however, oversimplified modelling assumptions and high computational cost compromise the accuracy of the information and impede clinical translation. To overcome these limitations, a patient-specific CFD multi-scale approach coupled to Windkessel boundary conditions and accounting for wall compliance was developed and used to study a patient with AD...
November 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/29116271/stereolithographic-hydrogel-printing-of-3d-culture-chips-with-biofunctionalized-complex-3d-perfusion-networks
#9
Rujing Zhang, Niels B Larsen
Three-dimensional (3D) in vitro models capturing both the structural and dynamic complexity of the in vivo situation are in great demand as an alternative to animal models. Despite tremendous progress in engineering complex tissue/organ models in the past decade, approaches that support the required freedom in design, detail and chemistry for fabricating truly 3D constructs have remained limited. Here, we report a stereolithographic high-resolution 3D printing technique utilizing poly(ethylene glycol) diacrylate (PEGDA, MW 700) to manufacture diffusion-open and mechanically stable hydrogel constructs as self-contained chips, where confined culture volumes are traversed and surrounded by perfusable vascular-like networks...
November 8, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/29107453/longitudinal-trends-and-predictors-of-statin-use-among-patients-with-diabetes
#10
Meghan B Brennan, Elbert S Huang, Jennifer M Lobo, Hyojung Kang, Marylou Guihan, Anirban Basu, Min-Woong Sohn
AIM: Statins reduce morbidity and mortality among patients with diabetes, but their use remains suboptimal. Understanding trends in statin use may inform strategies for improvement. METHODS: We enrolled a national, retrospective cohort of 899,664 veterans aged≥40years with diabetes in 2003. We followed them through 2011, dividing the nine-year follow-up into 90-day periods. For each period, we determined statin use, defined as possession of ≥30-day supply. We examine factors associated with statin uptake among baseline non-users with a multivariate model...
September 25, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29104545/the-adenosine-hypothesis-revisited-modulation-of-coupling-between-myocardial-perfusion-and-arterial-compliance
#11
Geoffrey P Dobson, Aryadi Arsyad, Hayley L Letson
For over four decades the thoracic aortic ring model has become one of the most widely used methods to study vascular reactivity and electromechanical coupling. A question that is rarely asked, however, is what function does a drug-mediated relaxation (or contraction) in this model serve in the intact system? The physiological significance of adenosine relaxation in rings isolated from large elastic conduit arteries from a wide range of species remains largely unknown. We propose that adenosine relaxation increases aortic compliance in acute stress states and facilitates ventricular-arterial (VA) coupling, and thereby links compliance and coronary artery perfusion to myocardial energy metabolism...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29097172/beyond-250-a-comprehensive-strategy-to-maximize-the-operative-experience-for-junior-residents
#12
James M Healy, Mark W Maxfield, Daniel G Solomon, Walter E Longo, Peter S Yoo
OBJECTIVES: Among surgical educators, duty-hour restrictions led to concern regarding the adequacy of operative experience during residency, especially for junior residents. The American Board of Surgery recently instituted guidelines mandating "a minimum of 250 operations by the end of the PGY-2 year". A series of programmatic and institutional changes were implemented at our institution to augment the junior resident operative experience and to exceed compliance with this mandate. METHODS: Operative data from Accreditation Council for Graduate Medical Education case logs for categorical and nondesignated preliminary interns from our large academic surgical residency were identified for 5 consecutive academic years, 2011 until 2016...
October 30, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/29082816/pilot-study-to-evaluate-the-potential-use-of-the-renal-resistive-index-as-a-preliminary-diagnostic-tool-for-chronic-kidney-disease-in-cats
#13
Ines Matos, Pedro Azevedo, L Miguel Carreira
Objectives Chronic kidney disease (CKD) is the most common renal pathology diagnosed in geriatric cats, and its prevalence increases with age. The arterial resistive index (RI) is important when evaluating vascular resistance and compliance, and can be applied in the kidney (renal RI [RRI]), allowing the evaluation of its vascular haemodynamics. The present study aimed to: (1) investigate in cats with CKD the relationships between the RRI and the following parameters: age, sex, body weight, plasmatic creatinine, blood urea nitrogen, potassium, urine specific gravity, urine protein:creatinine ratio, systolic arterial pressure; and (2) evaluate the potential use of the RRI as a preliminary diagnostic tool in cats with CKD...
October 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29079564/attenuated-superoxide-dismutase-2-activity-induces-atherosclerotic-plaque-instability-during-aging-in-hyperlipidemic-mice
#14
Aleksandr E Vendrov, Mark D Stevenson, Samthosh Alahari, Hua Pan, Samuel A Wickline, Nageswara R Madamanchi, Marschall S Runge
BACKGROUND: Atherosclerosis progression during aging culminates in the development of vulnerable plaques, which may increase the risk of cardiovascular events. Increased generation and/or decreased scavenging of reactive oxygen species in the vascular wall are major contributors to atherogenesis. We previously showed that superoxide dismutase 2 deficiency increased vascular oxidative stress and reduced aortic compliance in aged wild-type mice and that young Apoe(-/-)/Sod2(+/-) had increased mitochondrial DNA damage and atherosclerosis versus young Apoe(-/-) mice...
October 27, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29074714/potential-for-non-invasive-assessment-of-lung-inhomogeneity-using-highly-precise-highly-time-resolved-measurements-of-gas-exchange
#15
James E Mountain, Peter Santer, David Patrick O'Neill, Nicholas M J Smith, Luca Ciaffoni, John H Couper, Grant A D Ritchie, Gus Hancock, Jonathan P Whiteley, Peter A Robbins
Inhomogeneity in the lung impairs gas exchange and can be an early marker of lung disease. We hypothesised that highly precise measurements of gas exchange contain sufficient information to quantify many aspects of the inhomogeneity non-invasively. Our aim was to explore whether one parameterization of lung inhomogeneity could both fit such data and provide reliable parameter estimates. A mathematical model of gas exchange in an inhomogeneous lung was developed, containing inhomogeneity parameters for compliance, vascular conductance and deadspace, all relative to lung volume...
October 26, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29073767/arterial-stiffness-is-associated-with-qtc-interval-prolongation-in-patients-with-heart-failure
#16
Salah Al-Zaiti, Samir Saba, Rodolfo Pike, Jennifer Williams, Fadi Khraim
BACKGROUND: A prolonged corrected QT (QTc) interval is a known risk factor for adverse cardiac events. Understanding the determinants and physiologic correlates of QTc is necessary for selecting proper strategies to reduce the risk of adverse events in high-risk patients. We sought to evaluate the role of arterial stiffness in heart failure as a determinant of QTc prolongation. METHOD: This was an observational study that recruited ambulatory heart failure patients (New York Heart Association Classes I-II) from an outpatient heart failure clinic...
January 1, 2017: Biological Research for Nursing
https://www.readbyqxmd.com/read/29072174/blood-lipid-tests-in-2017
#17
Rémy Couderc, Marianne Antar, Dominique Bonnefont-Rousselot, Jean-Louis Paul, Patrice Therond
Strong epidemiological evidence supports a causal relationship between dyslipidemia and atherosclerotic cardio-vascular disease, which remains the leading cause of death and morbidity worldwide. A lipid profile (total cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides) is recommended at the initial evaluation for the assessment of the cardio-vascular risk. A commentary of the lipid profile for the clinician and mostly for the patient should be stated on the lab report. Quantifying the cardio-vascular risk using the SCORE (systematic coronary risk estimation) system, as recommended by the Haute autorité de santé (HAS), is the starting point to establish therapeutic goals and treatment strategies...
October 26, 2017: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/29068914/compliance-and-adherence-of-patients-with-diabetic-macular-edema-to-intravitreal-anti-vascular-endothelial-growth-factor-therapy-in-daily-practice
#18
Maximilian Weiss, Dawn A Sim, Tina Herold, Ricarda G Schumann, Raffael Liegl, Christoph Kern, Thomas Kreutzer, Johannes Schiefelbein, Miriam Rottmann, Siegfried Priglinger, Karsten Ulrich KortUEm
PURPOSE: We assessed differences in compliance and adherence (lateness of patients, visual acuity, reasons for abstaining) between patients with diabetic macular edema (DME) and patients with age-related macular degeneration (AMD), both under anti-vascular endothelial growth factor therapy. METHODS: We included 136 patients with DME (36% women, 65 years, 22 visits, 13.9 injections, and 29.9 months of follow-up) and 109 patients with AMD (59% women, 76 years, 20 visits, 14...
October 24, 2017: Retina
https://www.readbyqxmd.com/read/29067771/arterial-stiffness-sex-and-age-difference-on-hypertensive-response-to-supine-bicycle-exercise
#19
Hyemoon Chung, Jong-Youn Kim, Byoung Kwon Lee, Pil-Ki Min, Young Won Yoon, Bum-Kee Hong, Se-Joong Rim, Hyuck Moon Kwon, Eui-Young Choi
Contributors to a hypertensive response to exercise (HTR) according to sex and age have not been fully evaluated. The authors analyzed a database of supine bicycle exercise stress echocardiography findings. HTR was defined as peak systolic blood pressure ≥210 mmHg for men and ≥190 mmHg for women during exercise. A total of 797 patients (306 [38%] women) were analyzed, with a mean age of 64 ± 10 years. Female sex, hypertension; higher left ventricular ejection fraction, effective arterial elastance, and pulse wave velocity; and lower total arterial compliance were significantly related to HTR...
October 25, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29064046/hla-infections-and-inflammation-in-early-stages-of-atherosclerosis-in-children-with-type-1-diabetes
#20
Michal Odermarsky, Erkki Pesonen, Timo Sorsa, Åke Lernmark, Pirkko J Pussinen, Petru Liuba
AIMS: This prospective study focuses on risk factors for arterial damage in children with type 1 diabetes (T1D). METHODS: Eighty children and adolescents with T1D were investigated twice, approximately 2 years apart, for carotid artery intima-media thickness (cIMT) and compliance (CAC), flow-mediated dilatation (FMD) of the brachial artery, and plasma levels of matrix metalloproteinase (MMP)-8. All subjects were genotyped for HLA. The number of respiratory tract infections (RTI) during the past year was obtained by a questionnaire in 56 patients...
October 24, 2017: Acta Diabetologica
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