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https://www.readbyqxmd.com/read/29678320/care-of-the-patient-with-a-peripheral-nerve-block
#1
Oluwatobi O Hunter, T Edward Kim, Edward R Mariano, T Kyle Harrison
Long-acting peripheral nerve blocks provide effective postoperative pain management, but there are risks associated with rendering an extremity insensate. Perianesthesia nurses play a major role in anticipating and mitigating risks and carefully monitoring patients for potential complications. This article presents uncommon but important considerations related to the care of patients with a peripheral nerve block. These include compartment syndrome, local anesthetic systemic toxicity, thermal injuries, falls, and fractures as well as their management and prevention...
April 17, 2018: Journal of Perianesthesia Nursing: Official Journal of the American Society of PeriAnesthesia Nurses
https://www.readbyqxmd.com/read/29669947/anti-cd19-car-t-cells-with-high-dose-melphalan-and-autologous-stem-cell-transplantation-for-refractory-multiple-myeloma
#2
Alfred L Garfall, Edward A Stadtmauer, Wei-Ting Hwang, Simon F Lacey, Jan Joseph Melenhorst, Maria Krevvata, Martin P Carroll, William H Matsui, Qiuju Wang, Madhav V Dhodapkar, Kavita Dhodapkar, Rituparna Das, Dan T Vogl, Brendan M Weiss, Adam D Cohen, Patricia A Mangan, Emily C Ayers, Selene Nunez-Cruz, Irina Kulikovskaya, Megan M Davis, Anne Lamontagne, Karen Dengel, Naseem Ds Kerr, Regina M Young, Donald L Siegel, Bruce L Levine, Michael C Milone, Marcela V Maus, Carl H June
BACKGROUND: Multiple myeloma is usually fatal due to serial relapses that become progressively refractory to therapy. CD19 is typically absent on the dominant multiple myeloma cell population but may be present on minor subsets with unique myeloma-propagating properties. To target myeloma-propagating cells, we clinically evaluated autologous T cells transduced with a chimeric antigen receptor (CAR) against CD19 (CTL019). METHODS: Subjects received CTL019 following salvage high-dose melphalan and autologous stem cell transplantation (ASCT)...
April 19, 2018: JCI Insight
https://www.readbyqxmd.com/read/29666748/mass-gathering-enhanced-syndromic-surveillance-for-the-8th-micronesian-games-in-2014-pohnpei-state-federated-states-of-micronesia
#3
Paul White, Salanieta Saketa, Eliaser Johnson, Sameer V Gopalani, Eliashib Edward, Charles Loney, Alize Mercier, Tebuka Toatu, Richard Wojcik, Sheri Lewis, Damian Hoy
Pohnpei State's Division of Primary Health Care implemented enhanced surveillance for early warning and detection of disease to support the 8th Micronesian Games (the Games) in July 2014. The surveillance comprised 11 point-of-care sentinel sites around Pohnpei, Federated States of Micronesia, collecting data daily for eight syndromes using standard case definitions. Each sentinel site reported total acute care encounters, total syndrome cases and the total for each syndrome. A public health response, including epidemiological investigation and laboratory testing, followed when syndrome counts reached predetermined threshold levels...
January 2018: Western Pacific Surveillance and Response Journal: WPSAR
https://www.readbyqxmd.com/read/29655716/colonic-fermentation-of-polyphenols-from-chilean-currants-ribes-spp-and-its-effect-on-antioxidant-capacity-and-metabolic-syndrome-associated-enzymes
#4
Alberto Burgos-Edwards, Felipe Jiménez-Aspee, Cristina Theoduloz, Guillermo Schmeda-Hirschmann
The Chilean wild currants Ribes magellanicum and R. punctatum are a good source of polyphenols. Polyphenolic-enriched extracts (PEEs) from both species were submitted to in vitro colonic fermentation to assess the changes in phenolic composition, antioxidant capacity and inhibition of metabolic syndrome-associated enzymes. The phenolic profiles of the fermented samples showed significant changes after 24 h incubation. Nine metabolites, derived from the microbial fermentation, were tentatively identified, including dihydrocaffeic acid, dihydrocaffeoyl-, dihydroferuloylquinic acid, 1-(3,4-dihydroxyphenyl)-3-(2,4,6-trihydroxyphenyl)propan-2-ol (3,4-diHPP-2-ol), among others...
August 30, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29652981/-metabolic-syndrome-in-hiv-patients-an-opportunity-for-nutritional-supplementation
#5
Wendy Valdivia-Caramantín, Julca Malca, Edward Mezones-Holguín
No abstract text is available yet for this article.
2018: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/29651678/performance-of-the-2015-us-preventive-services-task-force-screening-criteria-for-prediabetes-and-undiagnosed-diabetes
#6
Matthew J O'Brien, Kai McKeever Bullard, Yan Zhang, Edward W Gregg, Mercedes R Carnethon, Namratha R Kandula, Ronald T Ackermann
BACKGROUND: In 2015, The US Preventive Services Task Force (USPSTF) recommended screening for prediabetes and undiagnosed diabetes (collectively called dysglycemia) among adults aged 40-70 years with overweight or obesity. The recommendation suggests that clinicians consider screening earlier in people who have other diabetes risk factors. OBJECTIVE: To compare the performance of limited and expanded screening criteria recommended by the USPSTF for detecting dysglycemia among US adults...
April 12, 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29622695/administration-of-mesenchymal-stem-cells-during-ecmo-results-in-a-rapid-decline-in-oxygenator-performance
#7
Jonathan Edward Millar, Viktor von Bahr, Maximillian V Malfertheiner, Katrina K Ki, Meredith A Redd, Nicole Bartnikowski, Jacky Y Suen, Danny Francis McAuley, John F Fraser
Mesenchymal stem cells (MSCs) have attracted attention as a potential therapy for Acute Respiratory Distress Syndrome (ARDS). At the same time, the use of extracorporeal membrane oxygenation (ECMO) has increased among patients with severe ARDS. To date, early clinical trials of MSCs in ARDS have excluded patients supported by ECMO. Here we provide evidence from an ex-vivo model of ECMO to suggest that the intravascular administration of MSCs during ECMO may adversely impact the function of a membrane oxygenator...
April 5, 2018: Thorax
https://www.readbyqxmd.com/read/29622165/respiratory-syncytial-virus-and-associations-with-cardiovascular-disease-in-adults
#8
REVIEW
Kelsey S Ivey, Kathryn M Edwards, H Keipp Talbot
Respiratory syncytial virus (RSV) is historically known for causing respiratory illness in young children, but the appreciation of its impact on older adults is growing. Studies have shown that hospitalization for respiratory illness due to RSV is complicated by cardiovascular events in 14% to 22% of adult patients, including worsening congestive heart failure, acute coronary syndrome, and arrhythmias. Additionally, underlying cardiovascular disease is associated with hospitalization in 45% to 63% of adults with confirmed RSV...
April 10, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29608398/a-high-throughput-flow-cytometry-screen-identifies-molecules-that-inhibit-hantavirus-cell-entry
#9
Tione Buranda, Catherine Gineste, Yang Wu, Virginie Bondu, Dominique Perez, Kaylin R Lake, Bruce S Edwards, Larry A Sklar
Hantaviruses cause hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS), which infects more than 200,000 people worldwide. Sin Nombre virus (SNV) and Andes virus (ANDV) cause the most severe form of HCPS, with case fatality ratios of 30%-40%. There are no specific therapies or vaccines for SNV. Using high-throughput flow cytometry, we screened the Prestwick Chemical Library for small-molecule inhibitors of the binding interaction between UV-inactivated and fluorescently labeled SNVR18 particles, and decay-accelerating factor (DAF) expressed on Tanoue B cells...
April 1, 2018: SLAS Discovery
https://www.readbyqxmd.com/read/29607552/pathophysiology-and-management-of-glaucoma-associated-with-phakomatoses
#10
REVIEW
Alisa T Thavikulwat, Deepak P Edward, Abdulrahman AlDarrab, Thasarat S Vajaranant
The phakomatoses, encephalotrigeminal angiomatosis (ETA; Sturge-Weber Syndrome), neurofibromatosis type 1 (NF1 or von Recklinghausen disease), Von Hippel-Lindau (VHL) disease, tuberous sclerosis (TSC), oculodermal melanocytosis (ODM), and phakomatosis pigmentovascularis are a group of neurocutaneous disorders that have characteristic systemic and ocular manifestations. Through many different mechanisms, they may cause glaucomatous damage of the optic nerve and subsequent vision loss varying from mild to severe...
April 1, 2018: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/29606355/fetal-neuropathology-in-zika-virus-infected-pregnant-female-rhesus-monkeys
#11
Amanda J Martinot, Peter Abbink, Onur Afacan, Anna K Prohl, Roderick Bronson, Jonathan L Hecht, Erica N Borducchi, Rafael A Larocca, Rebecca L Peterson, William Rinaldi, Melissa Ferguson, Peter J Didier, Deborah Weiss, Mark G Lewis, Rafael A De La Barrera, Edward Yang, Simon K Warfield, Dan H Barouch
The development of interventions to prevent congenital Zika syndrome (CZS) has been limited by the lack of an established nonhuman primate model. Here we show that infection of female rhesus monkeys early in pregnancy with Zika virus (ZIKV) recapitulates many features of CZS in humans. We infected 9 pregnant monkeys with ZIKV, 6 early in pregnancy (weeks 6-7 of gestation) and 3 later in pregnancy (weeks 12-14 of gestation), and compared findings with uninfected controls. 100% (6 of 6) of monkeys infected early in pregnancy exhibited prolonged maternal viremia and fetal neuropathology, including fetal loss, smaller brain size, and histopathologic brain lesions, including microcalcifications, hemorrhage, necrosis, vasculitis, gliosis, and apoptosis of neuroprogenitor cells...
March 28, 2018: Cell
https://www.readbyqxmd.com/read/29590444/extremely-delayed-diagnosis-of-type-ii-hereditary-angioedema-case-report-and-review-of-the-literature
#12
Jeremy Berger, Michael P Carroll, Edward Champoux, Christopher A Coop
We present a case with extremely late diagnosis of type II hereditary angioedema (HAE). Given recent advances in HAE treatment, we want to bring physician awareness to this condition and aid in earlier detection. HAE is a disorder associated with episodes of angioedema of the face, larynx, lips, abdomen, or extremities. Late diagnosis of HAE can lead to significant morbidity and is severely impairing due to recurring attacks. The diagnosis of HAE is ordinarily made during childhood and adolescence. Delayed diagnoses in early and middle adulthood have been documented in the literature...
March 26, 2018: Military Medicine
https://www.readbyqxmd.com/read/29582897/dietary-restriction-ameliorates-age-related-increase-in-dna-damage-senescence-and-inflammation-in-mouse-adipose-tissuey
#13
A Ishaq, J Schröder, N Edwards, T von Zglinicki, G Saretzki
Ageing is associated with redistribution of fat around the body and saturation of visceral adipose depots. Likewise, the presence of excess fat in obesity or during ageing places extra stress on visceral depots, resulting in chronic inflammation and increased senescence. This process can contribute to the establishment of the metabolic syndrome and accelerated ageing. Dietary restriction (DR) is known to alleviate physiological signs of inflammation, ageing and senescence in various tissues including adipose tissue...
2018: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29581889/non-traumatic-myelopathy-associated-with-prolonged-hyperextension-during-swimming-an-unusual-variation-of-surfer-s-myelopathy
#14
Edward Green, Umme Sara Zishan, Nicola Robertson, Joseph Papanikitas, Sarah Yanny, Richard Hughes, David McKean
Introduction: Surfer's myelopathy (SM) is a rare cause on non-traumatic acute myelopathy. This has classically been described in novice surfers however has been reported in other scenarios. Case presentation: We present a case of non-traumatic paraparesis associated with prolonged cervical hyperextension during swimming with imaging characteristics consistent with an unusual variation of SM in a swimmer. Discussion: SM and its variants should be considered in the differential diagnosis of any patient presenting with an anterior spinal cord syndrome with a history of either sustained or repeated spinal hyperextension...
2018: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/29580790/recognition-of-neonatal-lymphatic-flow-disorder-fetal-mr-findings-and-postnatal-mr-lymphangiogram-correlation
#15
David M Biko, Jordan A Johnstone, Yoav Dori, Teresa Victoria, Edward R Oliver, Maxim Itkin
RATIONALE AND OBJECTIVES: This study aimed to describe prenatal and postnatal imaging features and outcomes of neonates with neonatal lymphatic disorders (NLDs). MATERIALS AND METHODS: An institutional review board-approved search of the radiology database for patients with NLD identified five patients. Inclusion criteria include prenatal imaging (fetal magnetic resonance [MR] imaging and ultrasound) and postnatal three-dimensional T2 Sampling Perfection with Application optimized Contrasts using different flip angle Evolution (SPACE) and dynamic contrast-enhanced MR lymphangiography within 6 months of life...
March 23, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29578632/a-case-of-hereditary-fibrosing-poikiloderma-with-tendon-contractures-myopathy-and-pulmonary-fibrosis-poiktmp-with-the-emphasis-on-cutaneous-histopathological-findings
#16
Viktoryia Kazlouskaya, Eleanor J Feldman, Jeanette Jakus, Edward Heilman, Sharon Glick
POIKTMP (POIKiloderma, Tendon contractures, Myopathy and Pulmonary fibrosis) is a recently described autosomal dominant genetic syndrome caused by mutation of FAM111B gene, encoding a protein with unknown function1 . The syndrome is confirmed in 4 families and nine sporadic cases1-6 . Skin lesions of POIKTMP are rarely biopcied2,3,5 . Most consistent histopathological findings include scleroderma-like fibrosis and degradation of elastic fibers with globule formation seen with elastic special stain2,3 . This article is protected by copyright...
March 26, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29575684/new-mutations-and-an-updated-database-for-the-patched-1-ptch1-gene
#17
Marie G Reinders, Antonius F van Hout, Betûl Cosgun, Aimée D Paulussen, Edward M Leter, Peter M Steijlen, Klara Mosterd, Michel van Geel, Johan J Gille
BACKGROUND: Basal cell nevus syndrome (BCNS) is an autosomal dominant disorder characterized by multiple basal cell carcinomas (BCCs), maxillary keratocysts, and cerebral calcifications. BCNS most commonly is caused by a germline mutation in the patched-1 (PTCH1) gene. PTCH1 mutations are also described in patients with holoprosencephaly. METHODS: We have established a locus-specific database for the PTCH1 gene using the Leiden Open Variation Database (LOVD). We included 117 new PTCH1 variations, in addition to 331 previously published unique PTCH1 mutations...
March 25, 2018: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/29575631/biallelic-loss-of-function-wnt5a-mutations-in-an-infant-with-severe-and-atypical-manifestations-of-robinow-syndrome
#18
Johannes Birgmeier, Edward D Esplin, Karthik A Jagadeesh, Harendra Guturu, Aaron M Wenger, Hassan Chaib, Julia A Buckingham, Gill Bejerano, Jonathan A Bernstein
Robinow syndrome (RS) is a well-recognized Mendelian disorder known to demonstrate both autosomal dominant and autosomal recessive inheritance. Typical manifestations include short stature, characteristic facies, and skeletal anomalies. Recessive inheritance has been associated with mutations in ROR2 while dominant inheritance has been observed for mutations in WNT5A, DVL1, and DVL3. Through trio whole genome sequencing, we identified a homozygous frameshifting single nucleotide deletion in WNT5A in a previously reported, deceased infant with a unique constellation of features comprising a 46,XY disorder of sex development with multiple congenital malformations including congenital diaphragmatic hernia, ambiguous genitalia, dysmorphic facies, shortened long bones, adactyly, and ventricular septal defect...
April 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29572158/a-phase-i-ii-trial-of-the-combination-of-azacitidine-and-gemtuzumab-ozogamicin-for-treatment-of-relapsed-acute-myeloid-leukemia
#19
Bruno C Medeiros, Tiffany N Tanaka, Larisa Balaian, Asad Bashey, Amy Guzdar, Hongying Li, Karen Messer, Edward D Ball
INTRODUCTION: Treatment with hypomethylating agent therapy might enhance anti-CD33 monoclonal antibody-mediated cytotoxicity against acute myeloid leukemia (AML) blasts through epigenetic effects on Syk and SHP-1 expression. PATIENTS AND METHODS: In the present phase I/II study, we treated patients with relapsed or refractory AML with azacitidine, followed by 2 doses of gemtuzumab ozogamicin (GO) at 6 mg/m2 , the Food and Drug Administration-approved dose and schedule at study initiation...
March 2, 2018: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/29571046/the-contributions-of-dr-kathleen-k-sulik-to-fetal-alcohol-spectrum-disorders-research-and-prevention
#20
REVIEW
Scott E Parnell, Edward P Riley, Kenneth R Warren, Kathleen T Mitchell, Michael E Charness
Dr. Kathleen Sulik (Kathy) has spent 35 years studying fetal alcohol syndrome (FAS) and fetal alcohol spectrum disorders (FASD). Beginning with her landmark 1981 Science paper describing the early gestational window when alcohol can cause the craniofacial malformations characteristic of FAS, Kathy has contributed a vast amount of research furthering our knowledge of FASD. After her seminal work that definitively demonstrated that alcohol is the causative factor in FAS, she and her lab went on to explore and define the stage-dependent effects of early gestational alcohol exposure on the face and brain in numerous different ways throughout her career...
March 20, 2018: Alcohol
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