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Troponin and exercise

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https://www.readbyqxmd.com/read/28096042/acute-effect-of-intermittent-and-continuous-aerobic-exercise-on-release-of-cardiac-troponin-t-in-sedentary-men
#1
Rouhollah Ranjbar, Mohammad Amin Ahmadi, Abdossaleh Zar, Peter Krustrup
BACKGROUND: Studies have shown that acute exercise can increase serum concentrations of cardiac biomarkers, including cardiac troponin T (cTnT). We investigated the acute effects of intermittent (IE) and continuous (CE) exercise at the same cardiac workload on myocardial necrosis biomarkers in sedentary men. METHODS: Eleven sedentary healthy men aged 22.3±1.9years completed the study. The subjects were divided into two groups and performed, in random order, IE (intensity alternating between 50% (2min) and 80% (1min) HRreserve) or CE (60% HRreserve)...
January 9, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28087154/evaluation-of-serial-high-sensitivity-troponin-t-levels-in-individuals-without-overt-coronary-heart-disease-following-exercise-stress-testing
#2
Yousef M E Saad, Hanan Idris, Ibrahim M Shugman, Krishna K Kadappu, Rohan Rajaratnam, Liza Thomas, Christian Mussap, Dominic Y C Leung, Craig P Juergens, John K French
BACKGROUND: Detectable levels of high sensitivity (cardiac) troponin T (HsTnT), occur in the majority of patients with stable coronary heart disease (CHD), and often in 'healthy' individuals. Extreme physical activity may lead to marked elevations in creatine kinase MB and TnT levels. However, whether HsTnT elevations occur commonly after exercise stress testing (EST), and if so, whether this has clinical significance, needs clarification. METHODS: To determine whether HsTnT levels become elevated after EST (Bruce protocol) to ≥95% of predicted maximum heart rate in presumed healthy subjects without overt CHD, we assayed HsTnT levels for ∼5h post-EST in 105 subjects (median age 37 years)...
December 9, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28027073/value-of-the-coronary-artery-disease-consortium-rule-in-patients-with-acute-chest-pain-and-negative-troponins-referred-for-exercise-stress-testing
#3
Alberto Bouzas-Mosquera, Jesús Peteiro, Francisco J Broullón, Ramón Calviño-Santos, Víctor X Mosquera, Dolores Martínez, Juan C Yáñez, Nemesio Álvarez-García, José M Vázquez-Rodríguez
OBJECTIVE: To assess the value of the pretest probability (PTP) of coronary artery disease (CAD) for predicting stress testing results and coronary events in patients with acute chest pain and negative troponins. PATIENTS AND METHODS: A total of 3527 patients without a history of CAD referred to our chest pain unit with suspected acute coronary syndromes, nondiagnostic ECGs, and negative troponin levels underwent exercise stress testing. PTP was estimated with the CAD consortium prediction rule, and was categorized as low (<15%), low-intermediate (15-65%), intermediate-high (66-85%), and high (>85%)...
December 23, 2016: European Journal of Emergency Medicine: Official Journal of the European Society for Emergency Medicine
https://www.readbyqxmd.com/read/28003565/histological-evidence-for-reversible-cardiomyocyte-changes-and-serum-cardiac-troponin-t-elevation-after-exercise-in-rats
#4
Jinlei Nie, Keith George, Fei Duan, Tomas K Tong, Ye Tian
This study characterized cardiac troponin T (cTnT) appearance and associated histological evidence of reversible or irreversible changes in myocardial ultrastructure, determined via electron microscopy, in rats undertaking isoproterenol (ISO) infusion or an endurance exercise challenge. Male rats were randomized into ISO and exercise groups. In ISO trials rats were killed 5 h (ISO-5H) and 24 h (ISO-REC19H) after a single ISO or saline injection (SAL-5H; SAL-REC19H). In the exercise trials rats were killed before, as a control (EXE-CON), immediately after (EXE-END5H) and 19 h after (EXE-REC19H) a 5-h bout of swimming with 5% body weight attached to their tail...
December 2016: Physiological Reports
https://www.readbyqxmd.com/read/27987278/clozapine-associated-cardiac-dysfunction-during-a-gastroenteritis-outbreak
#5
Anthony M Szema, Charles Marboe, Paul Fritz, Tram N B Nguyen
We report that two young adult patients who were initiated with clozapine for severe psychosis during a hospital-wide gastroenteritis outbreak went into severe shock. Neither patient had troponin elevation. Each required left ventricular assist device support for myocarditis. Endomyocardial biopsy revealed lymphocytic myocarditis in one patient and eosinophilic myocarditis in the other. The former patient expired. Polymerase chain reaction testing was negative for Coxsackie virus. These two patients illustrate that myocarditis can occur at usual incipient doses and that there may be an epidemiologic risk associated with gastroenteritis...
2016: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/27942149/the-effects-of-the-intake-of-an-isotonic-sports-drink-before-orienteering-competitions-on-skeletal-muscle-damage
#6
Filiz Fatma Colakoglu, Banu Cayci, Metin Yaman, Selma Karacan, Suleyman Gonulateş, Gökhan Ipekoglu, Fatmanur Er
[Purpose] The purpose of this study was to investigate the effects of the intake of an isotonic sports drink (500 ml water, 32 gr carbonhydrate, 120 mg calcium, 248 mg chloride, 230 mg sodium) the level of the skeletal muscle damage of orienteering athletes. [Subjects and Methods] The study was carried out on 21 male elite orienteering athletes. The athletes were divided into two groups by randomized double-blind selection. The experimental group (n=11) was given the isotonic sports drink, while the placebo group (n=10) was given 500 ml pure water...
November 2016: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/27930383/effect-of-e-oj-01-on-cardiac-conditioning-in-young-exercising-adults-a-randomized-controlled-trial
#7
Robert N Girandola, Shalini Srivastava
BACKGROUND AND AIM: Cardiac health is a determinant of athletic performance. A body of data suggests that in healthy young adults, an increase in maximal cardiac output leads to an increase in endurance. Terminalia arjuna (TA) has been studied for multiple benefits in cardiovascular health although its effects as a cardioprotective ergogenic aid require further exploration. The current trial was planned to study the effect of the proprietary TA extract (E-OJ-01) on the markers of cardiac conditioning in healthy young adults...
November 29, 2016: American Journal of Therapeutics
https://www.readbyqxmd.com/read/27879166/sex-differences-in-release-of-cardiac-troponin-t-after-endurance-exercise
#8
Zhaowei Kong, Jinlei Nie, Hua Lin, Keith George, Gang Zhao, Haifeng Zhang, Tomas K Tong, Qingde Shi
CONTEXT: Post-exercise cardiac troponin release has been extensively described in athletic groups but little attention has been given to any role of sex in mediating this phenomenon. OBJECTIVE: We compared the release of cardiac troponin T (cTnT) after endurance running in training-experience, biological-age and maturity-matched young male and female runners. MATERIALS AND METHODS: Nineteen male (training history: 2.3 ± 1.0 years; mean age: 16...
December 8, 2016: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/27865641/canadian-cardiovascular-society-guidelines-on-perioperative-cardiac-risk-assessment-and-management-for-patients-who-undergo-noncardiac-surgery
#9
Emmanuelle Duceppe, Joel Parlow, Paul MacDonald, Kristin Lyons, Michael McMullen, Sadeesh Srinathan, Michelle Graham, Vikas Tandon, Kim Styles, Amal Bessissow, Daniel I Sessler, Gregory Bryson, P J Devereaux
The Canadian Cardiovascular Society Guidelines Committee and key Canadian opinion leaders believed there was a need for up to date guidelines that used the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system of evidence assessment for patients who undergo noncardiac surgery. Strong recommendations included: 1) measuring brain natriuretic peptide (BNP) or N-terminal fragment of proBNP (NT-proBNP) before surgery to enhance perioperative cardiac risk estimation in patients who are 65 years of age or older, are 45-64 years of age with significant cardiovascular disease, or have a Revised Cardiac Risk Index score ≥ 1; 2) against performing preoperative resting echocardiography, coronary computed tomography angiography, exercise or cardiopulmonary exercise testing, or pharmacological stress echocardiography or radionuclide imaging to enhance perioperative cardiac risk estimation; 3) against the initiation or continuation of acetylsalicylic acid for the prevention of perioperative cardiac events, except in patients with a recent coronary artery stent or who will undergo carotid endarterectomy; 4) against α2 agonist or β-blocker initiation within 24 hours before surgery; 5) withholding angiotensin-converting enzyme inhibitor and angiotensin II receptor blocker starting 24 hours before surgery; 6) facilitating smoking cessation before surgery; 7) measuring daily troponin for 48 to 72 hours after surgery in patients with an elevated NT-proBNP/BNP measurement before surgery or if there is no NT-proBNP/BNP measurement before surgery, in those who have a Revised Cardiac Risk Index score ≥1, age 45-64 years with significant cardiovascular disease, or age 65 years or older; and 8) initiating of long-term acetylsalicylic acid and statin therapy in patients who suffer myocardial injury/infarction after surgery...
January 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/27864509/loss-of-%C3%AE-adrenergic-stimulated-phosphorylation-of-cav1-2-channels-on-ser1700-leads-to-heart-failure
#10
Linghai Yang, Dao-Fu Dai, Can Yuan, Ruth E Westenbroek, Haijie Yu, Nastassya West, Horacio O de la Iglesia, William A Catterall
L-type Ca(2+) currents conducted by voltage-gated calcium channel 1.2 (CaV1.2) initiate excitation-contraction coupling in the heart, and altered expression of CaV1.2 causes heart failure in mice. Here we show unexpectedly that reducing β-adrenergic regulation of CaV1.2 channels by mutation of a single PKA site, Ser1700, in the proximal C-terminal domain causes reduced contractile function, cardiac hypertrophy, and heart failure without changes in expression, localization, or function of the CaV1.2 protein in the mutant mice (SA mice)...
December 6, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27701829/the-vhot-vindaloo-hastens-outpouring-of-troponins-study
#11
Alan S Tankel, Yusuf Nagree, Peter Jones, David Mountain, Stephen Pj Macdonald, Paul Hill, Martin Than
BACKGROUND: Multiple cardiac and non-cardiac processes may cause an elevated highly sensitive troponin (hsTn). We postulated that the consumption of a seriously hot vindaloo could cause an increase in hsTn levels in seemingly healthy volunteers. OBJECTIVE: To determine whether eating a very hot curry can cause elevated hsTn. METHODS: This was a prospective observational cohort study. Participants had blood drawn for hsTn pre-ingestion and at 2 and 4 h post-ingestion of, first, a rather mild butter chicken and, 2 weeks later, a seriously hot lamb vindaloo...
December 2016: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/27686126/relationship-between-hstni-and-coronary-stenosis-in-asymptomatic-women-with-rheumatoid-arthritis
#12
Milan Hromádka, Jitka Seidlerová, Jan Baxa, David Suchý, Daniel Rajdl, Jakub Šedivý, Richard Rokyta
BACKGROUND: Rheumatoid arthritis (RA) is a condition associated with accelerated progression of atherosclerosis in affected individuals. Myocardial assessment using exercise testing in such patients, however, is often difficult to perform. Our objective was to determine the factors associated with severe coronary stenosis using computed tomography (CT) angiography of the coronary arteries in asymptomatic patients with RA. METHODS: Forty-four women with RA were examined using CT angiography to detect atherosclerotic involvement and significant coronary stenosis (>50 %)...
September 29, 2016: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/27634411/a-33-year-old-man-with-atypical-chest-pain
#13
Alastair J Moss, Marc R Dweck, Andrew D Flapan
CLINICAL INTRODUCTION: A 33-year-old man with no history of coronary artery disease presented to the rapid access cardiology clinic with an episode of atypical anginal chest pain. He had a 15 pack-year history of smoking and a family history of myocardial infarction under the age of 55. Physical examination and exercise ECG testing were unremarkable. On assessment in the cardiology clinic, blood sampling was notable for an elevated high-sensitivity troponin I of 61 ng/L (99% upper reference level, 34 ng/L)...
September 15, 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/27609306/individual-responses-in-biomarkers-of-health-after-marathon-and-half-marathon-running-is-age-a-factor-in-troponin-changes
#14
Markus Niemelä, Päivikki Kangastupa, Onni Niemelä, Risto Bloigu, Tatu Juvonen
Although strenuous physical activity is known to cause notable perturbations in blood chemistries, only few studies exist observing exercise-induced simultaneous changes in biomarkers of health status. We compared markers of muscle, cardiovascular, renal, hepatic and inflammatory status at baseline and at 3-h and at 48-h postrace in recreational runners who successfully completed either a marathon (mean age 27 ± 13 years, finishing time 199 ± 8 min, n = 4) or half-marathon (mean age 38 ± 13 years, finishing time 131 ± 6 min, n = 6) race...
November 2016: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/27595690/impact-of-moderate-physical-activity-on-the-longitudinal-trajectory-of-a-cardiac-specific-biomarker-of-injury-results-from-a-randomized-pilot-study-of-exercise-intervention
#15
Christopher R deFilippi, James A de Lemos, Anne B Newman, Jack M Guralnik, Robert H Christenson, Marco Pahor, Timothy Church, Mark Espeland, Stephen B Krithevsky, Randall Stafford, Stephen L Seliger
BACKGROUND: In animal models, physical activity (PA) prevents cardiac myocyte cell death. Data for PA mitigating myocyte injury in humans are limited to observational studies. Using a randomized controlled trial design, we sought to determine if introducing moderate PA to previously sedentary older adults could reduce the trajectory of myocardial injury as measured by the high-sensitive cardiac troponin T (hs-cTnT) assay. METHODS: Participants (age ≥70 years) were assigned to a 1-year intervention of moderate PA or health education control...
September 2016: American Heart Journal
https://www.readbyqxmd.com/read/27585757/early-invasive-versus-non-invasive-treatment-in-patients-with-non-st-elevation-acute-coronary-syndrome-frisc-ii-15-year-follow-up-of-a-prospective-randomised-multicentre-study
#16
RANDOMIZED CONTROLLED TRIAL
Lars Wallentin, Lars Lindhagen, Elisabet Ärnström, Steen Husted, Magnus Janzon, Søren Paaske Johnsen, Frederic Kontny, Tibor Kempf, Lars-Åke Levin, Bertil Lindahl, Mats Stridsberg, Elisabeth Ståhle, Per Venge, Kai C Wollert, Eva Swahn, Bo Lagerqvist
BACKGROUND: The FRISC-II trial was the first randomised trial to show a reduction in death or myocardial infarction with an early invasive versus a non-invasive treatment strategy in patients with non-ST-elevation acute coronary syndrome. Here we provide a remaining lifetime perspective on the effects on all cardiovascular events during 15 years' follow-up. METHODS: The FRISC-II prospective, randomised, multicentre trial was done at 58 Scandinavian centres in Sweden, Denmark, and Norway...
October 15, 2016: Lancet
https://www.readbyqxmd.com/read/27572505/the-impact-of-intermittent-exercise-in-a-hypoxic-environment-on-redox-status-and-cardiac-troponin-release-in-the-serum-of-well-trained-marathon-runners
#17
Feifei Li, Jinlei Nie, Yifan Lu, Tom Kwok Keung Tong, Longyan Yi, Huiping Yan, Frank Hoo Kin Fu, Shengxia Ma
PURPOSE: To investigate the effects of hypoxic training on redox status and cardiac troponin (cTn) release after intermittent exercise. METHOD: Nine well-trained male marathon runners (age, 21.7 ± 2.3 year; body mass, 64.7 ± 4.8 kg; height, 177.9 ± 3.8 cm; and VO2max, 64.3 ± 6.7 ml kg(-1) min(-1)) completed intermittent exercise under normoxic [trial N; fraction of inspiration oxygen (FIO2), 21.0 %] and hypoxic (trial H; FIO2, 14.4 %) conditions in random order...
October 2016: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/27538864/antemortem-screening-for-left-ventricular-hypertrophy-in-rhesus-macaques-macaca-mulatta
#18
Andrew J Haertel, Joshua A Stern, J Rachel Reader, Abigail Spinner, Jeffrey A Roberts, Kari L Christe
Concentric left ventricular hypertrophy (LVH) is a hallmark finding in hypertrophic cardiomyopathy that leads to diastolic dysfunction and variable cardiac consequences as severe as congestive heart failure and sudden cardiac death. LVH was diagnosed postmortem in a large colony of rhesus macaques (Macaca mulatta), but methods to screen and diagnose LVH in living animals are desired. We hypothesized that targeted echocardiography of macaques with a familial association of LVH would yield antemortem LVH diagnoses...
2016: Comparative Medicine
https://www.readbyqxmd.com/read/27530134/the-impact-of-moderate-distance-recreational-running-and-ageing-on-cardiac-physiology
#19
Jonathan H Kim, Yi-An Ko, Jeff Hedley, James MacNamara, Mosaab Awad, William Taylor, Sean Healy, Hiroshi Aida, Ngoc-Anh Le, Peter W Wilson, Melissa White, Laurence S Sperling, Joseph S Wilson, Aaron L Baggish
OBJECTIVE: Exercise-induced cardiac dysfunction and corollary biomarker release have been documented following long-distance running events. To what degree these processes occur during shorter distance running events is unknown. METHODS: 72 healthy recreational runners (54% male/46% female) recruited by age (group 1 (18-20 years old, N=19); group 2 (45-50 years old, N=27); group 3 (70-75 years old, N=26)) were studied with echocardiography and biochemical profiling during participation in a 10 km running race...
August 16, 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/27494731/no-evidence-of-adverse-cardiac-remodeling-in-former-elite-endurance-athletes
#20
Fabian Sanchis-Gomar, Marta López-Ramón, Rafael Alis, Nuria Garatachea, Helios Pareja-Galeano, Alejandro Santos-Lozano, Pilar Catalán, Veronica Sansoni, Silvia Perego, Giovanni Lombardi, Herbert Löllgen, Hector Bueno, Enrique Serrano-Ostáriz, Alejandro Lucia
BACKGROUND: The impact of high exercise loads on a previously healthy heart remains controversial. We examined the consequences of decades of strenuous endurance exercise at the highest competition level on heart dimensions and volumes as well as on serum biomarkers of cardiac fibrosis/remodeling. METHODS AND RESULTS: We compared echocardiographic measurements and serum biomarkers of cardiac fibrosis/remodeling [troponin I, galectin-3, matrix metallopeptidase-2 and -9, N-terminal pro-brain natriuretic peptide, carboxy-terminal propeptide of type I procollagen, and soluble suppressor of tumorigenicity-2 (sST-2)/interleukin(IL)-1R4] in 53 male athletes [11 former professional ('elite') and 42 amateur-level ('sub-elite') cyclists or runners, aged 40-70years] and 18 aged-matched controls...
November 1, 2016: International Journal of Cardiology
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