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Troponin and exercise

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https://www.readbyqxmd.com/read/27879166/sex-differences-in-release-of-cardiac-troponin-t-after-endurance-exercise
#1
Zhaowei Kong, Jinlei Nie, Hua Lin, Keith George, Gang Zhao, Haifeng Zhang, Tomas K Tong, Qingde Shi
CONTEXT: Post-exercise cardiac troponin release has been extensively described in athletic groups but little attention has been given to any role of sex in mediating this phenomnenon. OBJECTIVE: We compared the release of cardiac troponin T (cTnT) after endurance running in training-experience, biological-age and maturity-matched young male and female runners. MATERIALS AND METHODS: Nineteen male (training history: 2.3±1.0 yr; mean age: 16...
November 23, 2016: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/27865641/canadian-cardiovascular-society-guidelines-on-perioperative-cardiac-risk-assessment-and-management-for-patients-who-undergo-noncardiac-surgery
#2
Emmanuelle Duceppe, Joel Parlow, Paul MacDonald, Kristin Lyons, Michael McMullen, Sadeesh Srinathan, Michelle Graham, Vikas Tandon, Kim Styles, Amal Bessissow, Daniel I Sessler, Gregory Bryson, P J Devereaux
The Canadian Cardiovascular Society Guidelines Committee and key Canadian opinion leaders believed there was a need for up to date guidelines that used the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system of evidence assessment for patients who undergo noncardiac surgery. Strong recommendations included: 1) measuring brain natriuretic peptide (BNP) or N-terminal fragment of proBNP (NT-proBNP) before surgery to enhance perioperative cardiac risk estimation in patients who are 65 years of age or older, are 45-64 years of age with significant cardiovascular disease, or have a Revised Cardiac Risk Index score ≥ 1; 2) against performing preoperative resting echocardiography, coronary computed tomography angiography, exercise or cardiopulmonary exercise testing, or pharmacological stress echocardiography or radionuclide imaging to enhance perioperative cardiac risk estimation; 3) against the initiation or continuation of acetylsalicylic acid for the prevention of perioperative cardiac events, except in patients with a recent coronary artery stent or who will undergo carotid endarterectomy; 4) against α2 agonist or β-blocker initiation within 24 hours before surgery; 5) withholding angiotensin-converting enzyme inhibitor and angiotensin II receptor blocker starting 24 hours before surgery; 6) facilitating smoking cessation before surgery; 7) measuring daily troponin for 48 to 72 hours after surgery in patients with an elevated NT-proBNP/BNP measurement before surgery or if there is no NT-proBNP/BNP measurement before surgery, in those who have a Revised Cardiac Risk Index score ≥1, age 45-64 years with significant cardiovascular disease, or age 65 years or older; and 8) initiating of long-term acetylsalicylic acid and statin therapy in patients who suffer myocardial injury/infarction after surgery...
October 4, 2016: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/27864509/loss-of-%C3%AE-adrenergic-stimulated-phosphorylation-of-cav1-2-channels-on-ser1700-leads-to-heart-failure
#3
Linghai Yang, Dao-Fu Dai, Can Yuan, Ruth E Westenbroek, Haijie Yu, Nastassya West, Horacio O de la Iglesia, William A Catterall
L-type Ca(2+) currents conducted by voltage-gated calcium channel 1.2 (CaV1.2) initiate excitation-contraction coupling in the heart, and altered expression of CaV1.2 causes heart failure in mice. Here we show unexpectedly that reducing β-adrenergic regulation of CaV1.2 channels by mutation of a single PKA site, Ser1700, in the proximal C-terminal domain causes reduced contractile function, cardiac hypertrophy, and heart failure without changes in expression, localization, or function of the CaV1.2 protein in the mutant mice (SA mice)...
November 18, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27701829/the-vhot-vindaloo-hastens-outpouring-of-troponins-study
#4
Alan S Tankel, Yusuf Nagree, Peter Jones, David Mountain, Stephen Pj Macdonald, Paul Hill, Martin Than
BACKGROUND: Multiple cardiac and non-cardiac processes may cause an elevated highly sensitive troponin (hsTn). We postulated that the consumption of a seriously hot vindaloo could cause an increase in hsTn levels in seemingly healthy volunteers. OBJECTIVE: To determine whether eating a very hot curry can cause elevated hsTn. METHODS: This was a prospective observational cohort study. Participants had blood drawn for hsTn pre-ingestion and at 2 and 4 h post-ingestion of, first, a rather mild butter chicken and, 2 weeks later, a seriously hot lamb vindaloo...
October 4, 2016: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/27686126/relationship-between-hstni-and-coronary-stenosis-in-asymptomatic-women-with-rheumatoid-arthritis
#5
Milan Hromádka, Jitka Seidlerová, Jan Baxa, David Suchý, Daniel Rajdl, Jakub Šedivý, Richard Rokyta
BACKGROUND: Rheumatoid arthritis (RA) is a condition associated with accelerated progression of atherosclerosis in affected individuals. Myocardial assessment using exercise testing in such patients, however, is often difficult to perform. Our objective was to determine the factors associated with severe coronary stenosis using computed tomography (CT) angiography of the coronary arteries in asymptomatic patients with RA. METHODS: Forty-four women with RA were examined using CT angiography to detect atherosclerotic involvement and significant coronary stenosis (>50 %)...
September 29, 2016: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/27634411/a-33-year-old-man-with-atypical-chest-pain
#6
Alastair J Moss, Marc R Dweck, Andrew D Flapan
CLINICAL INTRODUCTION: A 33-year-old man with no history of coronary artery disease presented to the rapid access cardiology clinic with an episode of atypical anginal chest pain. He had a 15 pack-year history of smoking and a family history of myocardial infarction under the age of 55. Physical examination and exercise ECG testing were unremarkable. On assessment in the cardiology clinic, blood sampling was notable for an elevated high-sensitivity troponin I of 61 ng/L (99% upper reference level, 34 ng/L)...
September 15, 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/27609306/individual-responses-in-biomarkers-of-health-after-marathon-and-half-marathon-running-is-age-a-factor-in-troponin-changes
#7
Markus Niemelä, Päivikki Kangastupa, Onni Niemelä, Risto Bloigu, Tatu Juvonen
Although strenuous physical activity is known to cause notable perturbations in blood chemistries, only few studies exist observing exercise-induced simultaneous changes in biomarkers of health status. We compared markers of muscle, cardiovascular, renal, hepatic and inflammatory status at baseline and at 3-h and at 48-h postrace in recreational runners who successfully completed either a marathon (mean age 27 ± 13 years, finishing time 199 ± 8 min, n = 4) or half-marathon (mean age 38 ± 13 years, finishing time 131 ± 6 min, n = 6) race...
November 2016: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/27595690/impact-of-moderate-physical-activity-on-the-longitudinal-trajectory-of-a-cardiac-specific-biomarker-of-injury-results-from-a-randomized-pilot-study-of-exercise-intervention
#8
Christopher R deFilippi, James A de Lemos, Anne B Newman, Jack M Guralnik, Robert H Christenson, Marco Pahor, Timothy Church, Mark Espeland, Stephen B Krithevsky, Randall Stafford, Stephen L Seliger
BACKGROUND: In animal models, physical activity (PA) prevents cardiac myocyte cell death. Data for PA mitigating myocyte injury in humans are limited to observational studies. Using a randomized controlled trial design, we sought to determine if introducing moderate PA to previously sedentary older adults could reduce the trajectory of myocardial injury as measured by the high-sensitive cardiac troponin T (hs-cTnT) assay. METHODS: Participants (age ≥70 years) were assigned to a 1-year intervention of moderate PA or health education control...
September 2016: American Heart Journal
https://www.readbyqxmd.com/read/27585757/early-invasive-versus-non-invasive-treatment-in-patients-with-non-st-elevation-acute-coronary-syndrome-frisc-ii-15-year-follow-up-of-a-prospective-randomised-multicentre-study
#9
RANDOMIZED CONTROLLED TRIAL
Lars Wallentin, Lars Lindhagen, Elisabet Ärnström, Steen Husted, Magnus Janzon, Søren Paaske Johnsen, Frederic Kontny, Tibor Kempf, Lars-Åke Levin, Bertil Lindahl, Mats Stridsberg, Elisabeth Ståhle, Per Venge, Kai C Wollert, Eva Swahn, Bo Lagerqvist
BACKGROUND: The FRISC-II trial was the first randomised trial to show a reduction in death or myocardial infarction with an early invasive versus a non-invasive treatment strategy in patients with non-ST-elevation acute coronary syndrome. Here we provide a remaining lifetime perspective on the effects on all cardiovascular events during 15 years' follow-up. METHODS: The FRISC-II prospective, randomised, multicentre trial was done at 58 Scandinavian centres in Sweden, Denmark, and Norway...
October 15, 2016: Lancet
https://www.readbyqxmd.com/read/27572505/the-impact-of-intermittent-exercise-in-a-hypoxic-environment-on-redox-status-and-cardiac-troponin-release-in-the-serum-of-well-trained-marathon-runners
#10
Feifei Li, Jinlei Nie, Yifan Lu, Tom Kwok Keung Tong, Longyan Yi, Huiping Yan, Frank Hoo Kin Fu, Shengxia Ma
PURPOSE: To investigate the effects of hypoxic training on redox status and cardiac troponin (cTn) release after intermittent exercise. METHOD: Nine well-trained male marathon runners (age, 21.7 ± 2.3 year; body mass, 64.7 ± 4.8 kg; height, 177.9 ± 3.8 cm; and VO2max, 64.3 ± 6.7 ml kg(-1) min(-1)) completed intermittent exercise under normoxic [trial N; fraction of inspiration oxygen (FIO2), 21.0 %] and hypoxic (trial H; FIO2, 14.4 %) conditions in random order...
October 2016: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/27538864/antemortem-screening-for-left-ventricular-hypertrophy-in-rhesus-macaques-macaca-mulatta
#11
Andrew J Haertel, Joshua A Stern, J Rachel Reader, Abigail Spinner, Jeffrey A Roberts, Kari L Christe
Concentric left ventricular hypertrophy (LVH) is a hallmark finding in hypertrophic cardiomyopathy that leads to diastolic dysfunction and variable cardiac consequences as severe as congestive heart failure and sudden cardiac death. LVH was diagnosed postmortem in a large colony of rhesus macaques (Macaca mulatta), but methods to screen and diagnose LVH in living animals are desired. We hypothesized that targeted echocardiography of macaques with a familial association of LVH would yield antemortem LVH diagnoses...
2016: Comparative Medicine
https://www.readbyqxmd.com/read/27530134/the-impact-of-moderate-distance-recreational-running-and-ageing-on-cardiac-physiology
#12
Jonathan H Kim, Yi-An Ko, Jeff Hedley, James MacNamara, Mosaab Awad, William Taylor, Sean Healy, Hiroshi Aida, Ngoc-Anh Le, Peter W Wilson, Melissa White, Laurence S Sperling, Joseph S Wilson, Aaron L Baggish
OBJECTIVE: Exercise-induced cardiac dysfunction and corollary biomarker release have been documented following long-distance running events. To what degree these processes occur during shorter distance running events is unknown. METHODS: 72 healthy recreational runners (54% male/46% female) recruited by age (group 1 (18-20 years old, N=19); group 2 (45-50 years old, N=27); group 3 (70-75 years old, N=26)) were studied with echocardiography and biochemical profiling during participation in a 10 km running race...
August 16, 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/27494731/no-evidence-of-adverse-cardiac-remodeling-in-former-elite-endurance-athletes
#13
Fabian Sanchis-Gomar, Marta López-Ramón, Rafael Alis, Nuria Garatachea, Helios Pareja-Galeano, Alejandro Santos-Lozano, Pilar Catalán, Veronica Sansoni, Silvia Perego, Giovanni Lombardi, Herbert Löllgen, Hector Bueno, Enrique Serrano-Ostáriz, Alejandro Lucia
BACKGROUND: The impact of high exercise loads on a previously healthy heart remains controversial. We examined the consequences of decades of strenuous endurance exercise at the highest competition level on heart dimensions and volumes as well as on serum biomarkers of cardiac fibrosis/remodeling. METHODS AND RESULTS: We compared echocardiographic measurements and serum biomarkers of cardiac fibrosis/remodeling [troponin I, galectin-3, matrix metallopeptidase-2 and -9, N-terminal pro-brain natriuretic peptide, carboxy-terminal propeptide of type I procollagen, and soluble suppressor of tumorigenicity-2 (sST-2)/interleukin(IL)-1R4] in 53 male athletes [11 former professional ('elite') and 42 amateur-level ('sub-elite') cyclists or runners, aged 40-70years] and 18 aged-matched controls...
November 1, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27430157/the-impact-of-remote-ischemic-preconditioning-on-cardiac-biomarker-and-functional-response-to-endurance-exercise
#14
S Cocking, T Landman, M Benson, R Lord, H Jones, D Gaze, D H J Thijssen, K George
Remote ischemic preconditioning (RIPC; repeated short reversible periods of ischemia) protects the heart against subsequent ischemic injury. We explored whether RIPC can attenuate post-exercise changes in cardiac troponin T (cTnT) and cardiac function in healthy individuals. In a randomized, crossover design, 14 participants completed 1-h cycling time trials (TT) on two separate visits; preceded by RIPC (arms/legs, 4 × 5-min 220 mmHg), or SHAM-RIPC (20 mmHg). Venous blood was sampled before and 0-, 1-, and 3-h post-exercise to assess high sensitivity (hs-)cTnT and brain natriuretic peptide (NT-proBNP)...
July 19, 2016: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/27420587/troponin-and-exercise
#15
REVIEW
T Gresslien, S Agewall
Cardiac troponins are the preferred biomarkers in diagnostic of myocardial infarction, but these markers also can rise in response to exercise. Multiple studies have assessed troponins post-exercise, but the results have varied and there have been disagreements about the mechanism of troponin release. The aim of this paper was to review the literature, and to consider factors and mechanisms regarding exercise-induced increase of troponin. 145 studies were found after a search in pubmed and inclusion of additional articles found in the reference list of the first articles...
October 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27380998/biomarkers-of-cardiovascular-stress-in-obstructive-sleep-apnea
#16
REVIEW
Micha T Maeder, Christian Mueller, Otto D Schoch, Peter Ammann, Hans Rickli
Obstructive sleep apnea (OSA) is a common sleep-related breathing disorder associated with "cardiovascular stress", i.e. cardiovascular risk factors, cardiovascular diseases, and an increased risk of heart failure, stroke, and death. Experimental and clinical studies have characterized potential underlying mechanisms including biventricular dysfunction, atherosclerosis, and arrhythmia. Assessment of these cardiovascular features of OSA requires a spectrum of clinical tools including ECG, echocardiography, exercise testing, and angiography...
September 1, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27364992/plasma-macrophage-migration-inhibitor-factor-is-elevated-in-response-to-myocardial-ischemia
#17
Fenling Fan, Lu Fang, Xiao-Lei Moore, Xuegang Xie, Xiao-Jun Du, David A White, Jessica O'Brien, Helen Thomson, Jun Wang, Hans G Schneider, Andris Ellims, Thomas W Barber, Anthony M Dart
BACKGROUND: Macrophage migration inhibitory factor (MIF) is a key regulator of inflammatory responses, including in the heart. Plasma MIF is elevated early in the course of acute myocardial infarction. In this study, we hypothesized that plasma MIF may also be increased in acute myocardial ischemia. METHODS AND RESULTS: Patients undergoing cardiac stress test (stress nuclear myocardial perfusion scan or stress echocardiography) were recruited. Twenty-two patients had a stress test indicative of myocardial ischemia and were compared with 62 patients who had a negative stress test...
July 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27305095/left-ventricular-function-after-prolonged-exercise-in-equine-endurance-athletes
#18
M Flethøj, C C Schwarzwald, M M Haugaard, H Carstensen, J K Kanters, L H Olsen, R Buhl
BACKGROUND: Prolonged exercise in human athletes is associated with transient impairment of left ventricular (LV) function, known as cardiac fatigue. Cardiac effects of prolonged exercise in horses remain unknown. OBJECTIVES: To investigate the effects of prolonged exercise on LV systolic and diastolic function in horses. ANIMALS: Twenty-six horses competing in 120-160 km endurance rides. METHODS: Cross-sectional field study...
July 2016: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/27282835/cardiac-troponin-t-and-i-release-after-a-30-km-run
#19
Lieke J J Klinkenberg, Peter Luyten, Noreen van der Linden, Kim Urgel, Daniëlle P C Snijders, Christian Knackstedt, Robert Dennert, Bastiaan L J H Kietselaer, Alma M A Mingels, Eline P M Cardinaels, Frederique E C M Peeters, Jeroen D E van Suijlen, Joop Ten Kate, Elke Marsch, Thomas L Theelen, Judith C Sluimer, Kristiaan Wouters, Otto Bekers, Sebastiaan C A M Bekkers, Luc J C van Loon, Marja P van Dieijen-Visser, Steven J R Meex
Prolonged endurance-type exercise is associated with elevated cardiac troponin (cTn) levels in asymptomatic recreational athletes. It is unclear whether exercise-induced cTn release mirrors a physiological or pathological underlying process. The aim of this study was to provide a direct comparison of the release kinetics of high-sensitivity cTnI (hs-cTnI) and T (hs-cTnT) after endurance-type exercise. In addition, the effect of remote ischemic preconditioning (RIPC), a cardioprotective strategy that limits ischemia-reperfusion injury, was investigated in a randomized controlled crossover manner...
July 15, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27170173/a-case-of-an-unexplained-eosinophilic-myocarditis-in-a-dog
#20
T P Keeshen, M Chalkley, C Stauthammer
An 8-year-old spayed female Munsterlander was evaluated for a chronic low grade fever and a two month history of exercise intolerance. On physical examination, tachycardia and a grade II/VI right systolic heart murmur were detected. Echocardiography revealed marked thickening of the atrial and ventricular walls with mixed echogenicity and concentric hypertrophy of the left and right ventricles and equivocal systolic dysfunction. Serum cardiac troponin I level was markedly elevated. Endomyocardial biopsy was attempted; however, the patient arrested during the procedure and resuscitation was unsuccessful...
September 2016: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
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