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Keywords
(Intracranial OR cerebral) AND...
(Intracranial OR cerebral) AND (athersclerosis OR stenosis OR occlusion)
#21
JOURNAL ARTICLE
Akihiro Hirayama, Azusa Sunaga, Kazuma Yokota, Hideaki Shigematsu, Takatoshi Sorimachi
Herein, we report three cases of cerebellar hemorrhage due to a ruptured small aneurysm located on a collateral artery compensating for one or more stenotic or occluded major cerebellar arteries. In each case, endovascular distant parent artery occlusion of both the collateral artery and aneurysm was performed to prevent rebleeding. A ruptured small aneurysm in a collateral artery may be observed in patients with hemorrhage in an atypical cerebellar region, especially in cases of stenosis or occlusion of the vertebral artery or posterior inferior cerebellar artery...
April 19, 2024: Acta Neurochirurgica
#22
JOURNAL ARTICLE
Cornelius Deuschl, Lukas Goertz, Christoph Kabbasch, Martin Köhrmann, Christoph Kleinschnitz, Ansgar Berlis, Christoph Johannes Maurer, Iris Mühlen, Bernd Kallmünzer, Matthias Gawlitza, Daniel P O Kaiser, Joachim Klisch, Donald Lobsien, Daniel Behme, Maximilian Thormann, Fabian Flottmann, Laurens Winkelmeier, Elke Ruth Gizewski, Lukas Mayer-Suess, Markus Holtmannspoetter, Christoph Moenninghoff, Martin Schlunz-Hendann, Dominik Grieb, Christophe T Arendt, Ferdinand O Bohmann, Jens Altenbernd, Yan Li, Ulrich Sure, Ruben Mühl-Benninghaus, Thomas Rodt, Kai Kallenberg, Alexandru Durutya, Mohamed Elsharkawy, Christian-Paul Stracke, Mathias Gerhard Schumann, Alexander Bock, Omid Nikoubashman, Martin Wiesmann, Hans Henkes, Sebastian Dolff, Aydin Demircioglu, Michael Forsting, Hanna Styczen
BACKGROUND: Data on impact of COVID-19 vaccination and outcomes of patients with COVID-19 and acute ischemic stroke undergoing mechanical thrombectomy are scarce. Addressing this subject, we report our multicenter experience. METHODS AND RESULTS: This was a retrospective analysis of patients with COVID-19 and known vaccination status treated with mechanical thrombectomy for acute ischemic stroke at 20 tertiary care centers between January 2020 and January 2023. Baseline demographics, angiographic outcome, and clinical outcome evaluated by the modified Rankin Scale score at discharge were noted...
April 19, 2024: Journal of the American Heart Association
#23
JOURNAL ARTICLE
Min-Qiang Bao, Yi-Nong Chen, Ji-Wei Jin, Dong-Dong Gui, Jie Wang, Shuang-Shuang Chen, Xiao-Ning Sheng, Zhang-Long Cheng, Yu Wang
BACKGROUND: Carotid duplex ultrasonography (DUS) is the primary screening tool for carotid artery stenosis, but has low reliability. MHR, which is the ratio of monocytes to high-density lipoprotein cholesterol (HDL-C), can be a marker for the degree and distribution of extracranial and intracranial atherosclerotic stenosis. OBJECTIVE: We determined the diagnostic value of DUS+MHR for internal carotid artery (ICA) stenosis. METHODS: We divided 273 hospitalized patients into non-stenosis (<50%) and ICA stenosis (≥50%) groups based on Digital Subtraction Angiography (DSA)...
April 18, 2024: Current medical imaging
#24
JOURNAL ARTICLE
Ziyan Jin, Zihong Shen, Siyang Yan, Guolei Chen, Yalong Yin, You Zhang, Xingui Wu
BACKGROUND: The use of proton pump inhibitors in the acute phase of cerebral infarction may lead to adverse long-term outcomes, this study aims to explore the potential of electroacupuncture (EA) in replacing omeprazole in exerting post-stroke gastrointestinal protection. METHODS: A permanent middle cerebral artery infarction model was established using the modified Longa thread occlusion technique. Gastrointestinal motility, gastrointestinal mucosal damage, cerebral infarct volume, and alterations in choline acetyltransferase (ChAT)-positive neurons within the dorsal motor nucleus of the vagus nerve (DMV) were assessed after 7 days of EA at Zusanli (ST36) or omeprazole intervention...
April 30, 2024: Heliyon
#25
Yasir Ilyas, Kıvanç Öncü, Kübra İlyas, Ahmet Beşi R
Moyamoya disease (MMD) is a rare non-inflammatory cerebral vasculopathy characterized by progressive stenosis of the internal carotid arteries, often bilaterally, and the formation of abnormal collateral vascular structures at the cranial base. A patient who underwent elective cesarean section (C/S) twice under spinal anesthesia and was diagnosed with MMD as a result of recurrent intracranial hemorrhage in the postpartum periods is presented. A 41-year-old female patient without any systemic comorbidity, gravida 2, parity 2, had her second cesarean section (C/S) operation under spinal anesthesia and was discharged on the third postoperative day without any problems...
March 2024: Curēus
#26
JOURNAL ARTICLE
Claudio Rodríguez-Fernández, Pedro Ruiz-Garcia, Maria Jesús Garcia-Sanchez, Martiel Manrique-Zegarra, Carlos Toledano-Illán, Jorge Escartin, Miguel Angel Vences, Luis Angel Rubio, Alex Luttich, José Manuel Pumar
BACKGROUND: Long-term follow-up of cerebral aneurysms treated with the Silk Vista Baby (SVB) flow diverter is lacking. This study aimed to assess the technical success, procedural safety, and efficacy of the SVB (Balt, Montmorency, France) for the treatment of intracranial aneurysms in small cerebral vessels over a mid-to long-term follow-up. METHODS: We retrospectively analyzed a prospectively maintained database of patients treated with the SVB between September 2018 and June 2021...
2024: Frontiers in Neurology
#27
JOURNAL ARTICLE
Adriana Knezic, Elena Budusan, Natalie J Saez, Brad R S Broughton, Lachlan D Rash, Glenn F King, Robert E Widdop, Claudia A McCarthy
Activation of acid-sensing ion channel 1a (ASIC1a) plays a major role in mediating acidosis-induced neuronal injury following a stroke. Therefore, the inhibition of ASIC1a is a potential therapeutic avenue for the treatment of stroke. Venom-peptide Hi1a, a selective and highly potent ASIC1a inhibitor, reduces the infarct size and functional deficits when injected into the brain after stroke in rodents. However, its efficacy when administered using a clinically relevant route of administration remains to be established...
April 12, 2024: ACS Pharmacology & Translational Science
#28
JOURNAL ARTICLE
Xue Xia, Xinsheng Han, Guangxin Xia, Xingquan Zhao, Anxin Wang
BACKGROUND: Obesity and metabolic syndrome (MetS) have been acknowledged to commonly co-exist and lead to increased risks of stroke, whereas the association between various BMI-based metabolic phenotypes and development of intracranial atherosclerotic stenosis (ICAS) remained controversial. METHODS: A total of 5355 participants were included from the Asymptomatic Polyvascular Abnormalities Community (APAC) study. Participants were categorized into six groups according to their body mass index (BMI) and MetS status...
April 18, 2024: International Journal of Obesity
#29
JOURNAL ARTICLE
T F Yu, X Ye, C Zeng, X L Chen, Yuanli Zhao
Objective: To investigate the imaging factors associated with postoperative cerebral infarction in adult patients aged 18 and above with ischemic Moyamoya disease. Methods: The clinical data of adult patients who underwent surgeries for ischemic Moyamoya disease in the Department of Neurosurgery at Peking University International Hospital from October 2015 to October 2020 were retrospectively analyzed. Of the 239 patients, 120 were male and 119 were female, with ages ranging from 18 to 63 (41.7±10.3) years...
April 16, 2024: Zhonghua Yi Xue za Zhi [Chinese medical journal]
#30
JOURNAL ARTICLE
Mengru Ge, Lingting Jin, Can Cui, Yingying Han, Hongxia Li, Xue Gao, Gang Li, Hongxiang Yu, Bei Zhang
Recent studies have highlighted the involvement of pyroptosis-mediated cell death and neuroinflammation in ischemic stroke (IS) pathogenesis. DL-3-n-butylphthalide (NBP), a synthesized compound based on an extract from seeds of Apium graveolens, possesses a broad range of biological effects. However, the efficacy and the underlying mechanisms of NBP in IS remain contentious. Herein, we investigated the therapeutic effects of NBP and elucidated its potential mechanisms in neuronal cell pyroptosis and microglia inflammatory responses...
April 16, 2024: European Journal of Pharmacology
#31
JOURNAL ARTICLE
Lihua Wang, Mingjie Li, Bing Liu, Ruihan Zheng, Xinyi Zhang, Shuoyi Yu
OBJECTIVE: Chronic cerebral hypoperfusion (CCH) is a common cause of brain dysfunction. As a microRNA (also known as miRNAs or miRs), miR-30a-5p participates in neuronal damage and relates to ferroptosis. We explored the in vivo and in vitro effects and functional mechanism of miR-30a-5p in CCH-triggered cognitive impairment through the silent information regulator 1 (SIRT1)/nuclear factor erythroid 2-related factor 2 (NRF2) pathway. METHODS: After 1 month of CCH modeling through bilateral common carotid artery stenosis, mice were injected with 2μL antagomir (also known as anti-miRNAs) miR-30a-5p, with cognitive function evaluated by Morris water maze and novel object recognition tests...
April 16, 2024: Brain Research Bulletin
#32
JOURNAL ARTICLE
Xiaozhu Hao, Luyi Lin, Chengfeng Sun, Chanchan Li, Jing Wang, Min Jiang, Zhenwei Yao, Yanmei Yang
BACKGROUND: Notch1 signaling inhibiton with N-[N-(3,5-difluorophenacetyl)-1-alanyl]-S-phenylglycine t-butylester] (DAPT) treatment could promote brain recovery and the intervention effect is different between striatum (STR) and cortex (CTX), which might be accounted for different changes of glial activities, but the in-depth mechanism is still unknown. The purpose of this study was to identify whether DAPT could modulate microglial subtype shifts and astroglial-endfeet aquaporin-4 (AQP4) mediated waste solute drainage...
April 17, 2024: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
#33
JOURNAL ARTICLE
Lin-Yan Huang, Yi-de Zhang, Yi-Ning Liu, Zhi-Yan Liang, Jie Chen, Bin Wang, Qi-Long Yin, Pei-Pei Wang, Wan Wang, Su-Hua Qi
Neuronal death resulting from ischemic stroke is the primary cause of adult mortality and disability, and effective neuroprotective agents for poststroke intervention are still lacking. Remote ischemic postconditioning (RIPostC) has demonstrated significant protective effects against ischemia in various organs; however, the specific mechanisms are not fully understood. This study investigated the potential neuroprotective mechanisms of RIPostC in the context of ischemic stroke. Using a rat model of middle cerebral artery occlusion, we found that RIPostC mitigated neurological damage, improved movement in the open-field test, and protected against neuronal apoptosis...
April 18, 2024: ACS Chemical Neuroscience
#34
JOURNAL ARTICLE
Sara Mazzucco, Linxin Li, Maria Assuncao Tuna, Peter M Rothwell
INTRODUCTION: Cerebral blood flow (CBF) declines with age and abnormalities in CBF are associated with age-related cerebrovascular disease and neurodegeneration. Women have higher CBF than men, although this sex-difference diminishes to some extent with age in healthy subjects. The physiological drivers of these age/sex differences are uncertain, but might be secondary to age and sex-differences in haemoglobin (Hb) level. Hb levels are inversely correlated with CBF, are lower in women, and decline with age in men, but the interrelations between these factors have not been explored systematically either in healthy subjects or across the full age-range in patients with vascular risk factors...
April 18, 2024: European Stroke Journal
#35
JOURNAL ARTICLE
Frederik Boxberg, Mohammad Al-Tibi, Katharina Schulz, Heinrich Lanfermann, Martin Schlunz-Hendann, Dominik Grieb
PURPOSE: We report our initial experience with endovascular embolization of intracranial aneurysms using this new self-expanding open-cell stent system (pEGASUS stent system) with the antithrombogenic hydrophilic polymer coating. MATERIALS AND METHODS: We retrospectively reviewed all patients treated with stent-assisted coiling or the Woven EndoBridge device using the pEGASUS stent system between September 2022 and June 2023. Demographic, clinical, and angiographic data were analyzed as well as short-term follow-up, including procedural complication rates and aneurysmal occlusion rates using the Raymond-Roy occlusion classification (RROC)...
April 18, 2024: Neurointervention
#36
JOURNAL ARTICLE
Yulong Huang, Xinsheng Xie, Guoqiang Huang, Weifeng Lu, Shichai Hong, Yihui Chen, Yue Lin, Weiguo Fu, Xiang Hong, Lixin Wang
OBJECTIVE: To review our multi-institutional experience with endovascular therapy for right subclavian artery occlusive disease and to evaluate the long-term outcomes. METHODS: We retrospectively evaluated all patients with right subclavian artery stenosis and occlusive disease who underwent endovascular therapy between March 2014 and September 2022 at two institutions. Patient baseline demographics, lesion characteristics, treatment strategies, and in-hospital and follow-up outcomes were prospectively collected and retrospectively analyzed...
April 17, 2024: Vascular
#37
Lei Zhang, Tianning Pu, Xiaotong Xu, Raynald, Shuai Zheng, Jingjing Fu, Qiang Yong, Wei Zhang, Wen He
No abstract text is available yet for this article.
April 16, 2024: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
#38
JOURNAL ARTICLE
Yun-An Lim, Li Si Tan, Wei Thye Lee, Wei Liang Sim, Yang Lv, Maki Takakuni, Satoshi Saito, Masafumi Ihara, Thiruma Valavan Arumugam, Christopher Chen, Fred Wai-Shiu Wong, Gavin Stewart Dawe
Vascular cognitive impairment (VCI) is the second leading cause of dementia with limited treatment options, characterised by cerebral hypoperfusion-induced white matter rarefaction (WMR). Subcortical VCI is the most common form of VCI, but the underlying reasons for region susceptibility remain elusive. Recent studies employing the bilateral cortical artery stenosis (BCAS) method demonstrate that various inflammasomes regulate white matter injury and blood-brain barrier dysfunction but whether caspase-1 inhibition will be beneficial remains unclear...
2024: PloS One
#39
JOURNAL ARTICLE
Visish M Srinivasan, Mohamed A Labib, Joshua S Catapano, Michael T Lawton
Galenic dural arteriovenous fistulas account for 1 of the 6 types of tentorial dural arteriovenous fistulas (type I). These fistulas are located around the great cerebral vein of Galen, with dural arterial supply through the tentorial arteries of Bernasconi and Cassinari or other posterior fossa branches, such as the posterior meningeal artery. In this case, a man in his 60s presented with a headache and was found to have this high-risk lesion, which was Borden grade III and Cognard grade IV. The lesion persisted despite embolization through the middle meningeal artery...
April 17, 2024: Operative Neurosurgery (Hagerstown, Md.)
#40
JOURNAL ARTICLE
Akshay Bhamidipati, Nishit Mummareddy, Seoiyoung Ahn, Gabriel Bendfeldt, Alexander T Lyons, Surya Gangavarapu, Jeffrey Chen, Jacob Jo, Naveed Kamal, Steven G Roth, Michael T Froehler, Rohan V Chitale, Matthew R Fusco
BACKGROUND: Post-mechanical thrombectomy (MT) intracranial hemorrhage (ICH) is a major source of morbidity in treated acute ischemic stroke patients with large vessel occlusion. ICH expansion may further contribute to morbidity. We sought to identify factors associated with ICH expansion on imaging evaluation post-MT. METHODS: We performed a retrospective cohort study of patients undergoing MT at a single comprehensive stroke center. Per protocol, patients underwent dual-energy head CT (DEHCT) post-MT followed by a 24-h interval non-contrast enhanced MRI...
April 17, 2024: Interventional Neuroradiology
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