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(Intracranial OR cerebral) AND (athersclerosis OR stenosis OR occlusion)

Yi Fang, Daoli Jiang, Yitong Wang, Qian Wang, Dongmei Lv, Jichao Liu, Chang Liu
Preclinical Research & Development The purpose of the present study is to evaluate the neuroprotective effect of recombinant human glucagon-like peptide-1 (rhGLP-1) as well as to explore corresponding mechanisms in diabetic rats with cerebral ischemia/reperfusion injury induced by middle cerebral artery occlusion (MCAO). Diabetes mellitus was induced by intraperitoneal injection of streptozotocin. The rats were pretreated with rhGLP-1 (20 μg/kg intraperitoneally, thrice a day) for 14 days. Thereafter, the rats were subjected to MCAO 90 min/reperfusion 24 hr...
September 17, 2018: Drug Development Research
Jordan C Patik, Wesley J Tucker, Bryon M Curtis, Michael D Nelson, Aida Nasirian, Suwon Park, Robert M Brothers
Consumption of a representative fast-food meal (FFMeal) acutely impairs peripheral conduit artery vascular function; however, the effect on cerebral vascular function remains unknown. This study tested the hypothesis that a FFMeal would impair cerebral vascular function as indexed by an attenuated increase in cerebral vascular conductance (CVCI) in the middle cerebral artery (MCA) during a hypercapnic challenge. Ten healthy men (age: 24 ± 3 years, BMI: 24.3 ± 3.8 kg/m2 ) were studied under two conditions; a standardized FFMeal (990 kcals, 50% fat, 36% carbohydrate, 14% protein, and 2120 mg sodium) and a fasting control condition...
September 2018: Physiological Reports
Tao Wen, Xiufeng Zhang, Shengxiang Liang, Zuanfang Li, Xuemei Xing, Weilin Liu, Jing Tao
BACKGROUND: To evaluate whether electroacupuncture (EA) at Baihui (DU20) and Shenting (DU24) acupoints could improve cognitive function and enhance spontaneous low-frequency brain activity in rats with ischemic stroke. METHODS: Total 36 rats were randomly divided into 3 groups-the sham surgery (Sham) group, the middle cerebral artery occlusion induced cognitive deficit (MICD) group, and the MICD with EA (MICD + EA) treatment group. The rats in MICD + EA group received EA treatment at DU20 and DU24 acupoints for 14 consecutive days after the surgery...
October 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Elena Jiménez-Xarrié, Belén Pérez, Ana Paula Dantas, Lídia Puertas-Umbert, Joan Martí-Fabregas, Ángel Chamorro, Anna Maria Planas, Elisabet Vila, Francesc Jiménez-Altayó
Hypertension is the most important modifiable risk factor for stroke and is associated with poorer post-stroke outcomes. The antioxidant uric acid is protective in experimental normotensive ischaemic stroke. However, it is unknown whether this treatment exerts long-term protection in hypertension. We aimed to evaluate the impact of transient intraluminal middle cerebral artery (MCA) occlusion (90 min)/reperfusion (1-15 days) on brain and vascular damage progression in adult male Wistar-Kyoto (WKY; n = 36) and spontaneously hypertensive (SHR; n = 37) rats treated (i...
September 15, 2018: Translational Stroke Research
Srikanth R Boddu, Y Pierre Gobin, Marc Dinkin, Cristiano Oliveira, Athos Patsalides
PURPOSE: The impact of venous sinus stenting (VSS) on vein of Labbé (VOL) drainage is poorly understood. The purpose of the study is to examine the incidence and potential high risk factors of impaired VOL drainage among idiopathic intracranial hypertension (IIH) patients following VSS. MATERIALS AND METHODS: Institutional review board approved prospective evaluation of all IIH patients who underwent VSS over a 5 year period (January 2012 to December 2017) at Weill Cornell Medical Center constituted the study population...
September 15, 2018: Journal of Neurointerventional Surgery
Boehme J, Wenz H, Al-Zghloul M, Alonso A, Groden C, Förster A
PURPOSE: Aim of this study was to evaluate the collateral blood flow between more distal branches of the middle cerebral artery (MCA) in the case of peripheral MCA branch occlusion on dynamic 4D angiograms. We sought to individually predict the finally resulting infarction volume with regard to the extent of collateral blood flow. METHODS: Overall, 35 acute ischemic stroke patients with peripheral MCA branch occlusion were included. Volumes of the ischemic infarctions and perfusion deficits were measured on diffusion weighted images DWI and time-to-peak TTP (>4S)...
September 13, 2018: Journal of Neuroradiology. Journal de Neuroradiologie
S W English, L McIntyre, V Saigle, M Chassé, D A Fergusson, A F Turgeon, F Lauzier, D Griesdale, A Garland, R Zarychanski, A Algird, C van Walraven
BACKGROUND: Conducting prospective epidemiological studies of hospitalized patients with rare diseases like primary subarachnoid hemorrhage (pSAH) are difficult due to time and budgetary constraints. Routinely collected administrative data could remove these barriers. We derived and validated 3 algorithms to identify hospitalized patients with a high probability of pSAH using administrative data. We aim to externally validate their performance in four hospitals across Canada. METHODS: Eligible patients include those ≥18 years of age admitted to these centres from January 1, 2012 to December 31, 2013...
September 15, 2018: BMC Medical Research Methodology
Anastasia Plotkin, Matthew G Bartley, Kathryn E Bowser, Jeniann A Yi, Gregory A Magee
The search for etiology of stroke in a young patient may present a diagnostic challenge. In rare cases, chronic trauma to the carotid artery may be the cause of cerebral thromboembolic events. The hyoid bone lies in close proximity to the carotid artery bifurcation, and anatomic variants have been implicated in carotid compression, stenosis, dissection, and pseudoaneurysm. We report a case of recurrent strokes in a 32 year-old woman due to an elongated hyoid bone causing thrombus formation in her right internal carotid artery (ICA) resulting in recurrent embolic strokes confirmed on diffusion-weighted magnetic resonance imaging (MRI)...
September 12, 2018: Annals of Vascular Surgery
Lukas Goertz, Christoph Kabbasch, Jan Borggrefe, Christina Hamisch, Sergej Telentschak, Niklas von Spreckelsen, Pantelis Stavrinou, Marco Timmer, Gerrit Brinker, Roland Goldbrunner, Boris Krischek
OBJECTIVE: Microsurgical clipping of aneurysms demands precise spatial understanding of aneurysm morphology and vascular geometry. We analyzed the impact of preoperative three-dimensional (3D) angiographic imaging on clinical and angiographic outcome after clipping of ruptured intracranial aneurysms (RIAs). METHODS: This is a retrospective analysis of consecutive patients that underwent microsurgical clipping during the acute phase of subarachnoid hemorrhage between 2010 and 2017...
September 12, 2018: World Neurosurgery
Xiaoyan Jiang, Jun Suenaga, Hongjian Pu, Zhishuo Wei, Amanda D Smith, Xiaoming Hu, Yejie Shi, Jun Chen
Post-stroke treatment with omega-3 polyunsaturated fatty acids (n-3 PUFAs) may be a promising therapy in young animals but this has not been tested in aged subjects, a population at most risk of ischemic stroke. Herein we examined the therapeutic efficacy of n-3 PUFAs after distal middle cerebral artery occlusion (dMCAO) in young (10-12 weeks old) and aged (18 months old) mice. Post-ischemic mice were randomly assigned to 4 groups that received: 1) regular food with low content of n-3 PUFAs, 2) intraperitoneal docosahexaenoic acid (DHA, a major component of n-3 PUFAs) injections, 3) Fish oil (FO, containing high concentration of n-3 PUFAs) dietary supplement, or 4) combined treatment with DHA and FO dietary supplement...
September 12, 2018: Neurobiology of Disease
Ralph Weber, Jens Minnerup, Hannes Nordmeyer, Jens Eyding, Christos Krogias, Jeffrie Hadisurya, Klaus Berger
BACKGROUND: In contrast to anterior circulation stroke (ACS), there is no evidence from randomized trials that mechanical thrombectomy (MT) with modern stent retrievers or thromboaspiration is safe and effective in posterior circulation stroke (PCS). METHODS: The present analysis was based on the prospective multicenter Registry on Revascularization in Ischemic Stroke Patients (REVASK) in Germany. We compared demographic data, periprocedural times and complications, recanalization rates, and functional outcome at discharge and after 3 months between 139 consecutive patients with PCS (84...
September 15, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
Ami P Raval, Marc Schatz, Pallab Bhattacharya, Nathan d'Adesky, Tatjana Rundek, W Dalton Dietrich, Helen M Bramlett
A risk of ischemic stroke increases exponentially after menopause. Even a mild-ischemic stroke can result in increased frailty. Frailty is a state of increased vulnerability to adverse outcomes, which subsequently increases risk of cerebrovascular events and severe cognitive decline, particularly after menopause. Several interventions to reduce frailty and subsequent risk of stroke and cognitive decline have been proposed in laboratory animals and patients. One of them is whole body vibration (WBV). WBV improves cerebral function and cognitive ability that deteriorates with increased frailty...
September 13, 2018: International Journal of Molecular Sciences
Libor Šimůnek, Antonín Krajina, Roman Herzig, Martin Vališ
INTRODUCTION: Causality of marijuana abuse with development of ischemic stroke has been indicated by numerous case reports and epidemiological studies. As a possible pathophysiological mechanism, the most common consideration is cardiac embolization during paroxysmal atrial fibrillation, systemic hypotension or multifocal intracerebral vasoconstriction. CASE REPORTS: We present three case reports of marijuana consumers who were admitted to our comprehensive stroke center due to ischemic stroke within 18-month period of our investigation...
2018: Acta Medica (Hradec Králové)
Jonathan A Norton, Lissa Peeling, Kotoo Meguro, Mike Kelly
Objective: To describe the changes in the shape and topology of the somatosensory evoked potential (SSEP) during carotid endarterectomy, with particular reference to the time of clamping. Methods: Routine intraoperative monitoring was performed on 30 patients undergoing carotid endarterectomy (15) or undergoing stenting (15) using median nerve SSEPs. Post-operatively the first and second derivatives of the potential were examined. Separate analysis of the SSEP using wavelets was also performed...
2018: Clinical Neurophysiology Practice
Anxin Liu, Weiwei Zhu, Lirui Sun, Guangming Han, Huiping Liu, Zhaoyu Chen, Li Zhuang, Wen Jiang, Xia Xue
High-mobility group box 1 (HMGB1) is released after focal cerebral ischemia/reperfusion (I/R), and aggravates brain tissue damage. Ginsenoside Rb1 (Rb1), isolated from Panax ginseng , has been reported to inhibit I/R-induced cell death in the brain. The present study aimed to investigate the protective ability of GRb1 on focal cerebral I/R rats and to explore its further mechanisms. A middle cerebral artery occlusion (MCAO) rat model was established and treated with different doses of Rb1. The neurological deficits were examined after reperfusion, and TTC staining was applied to assess the infarct volume...
October 2018: Experimental and Therapeutic Medicine
S S Lu, M Qi, X Zhang, X H Mu, M Schmidt, Y Sun, C Forman, P Speier, X N Hong
BACKGROUND AND PURPOSE: Time-of-flight MR angiography is the preferred imaging technique to assess intracranial arterial stenosis but is limited by a relatively long acquisition time. Compressed sensing provides an innovative approach in undersampling k -space to minimize the data-acquisition time. We aimed to evaluate the diagnostic accuracy of compressed sensing TOF for detecting intracranial arterial stenosis by comparison with conventional parallel imaging TOF-MRA. MATERIALS AND METHODS: Compressed sensing TOF and parallel imaging TOF were performed in 22 patients with intracranial arterial stenosis...
September 13, 2018: AJNR. American Journal of Neuroradiology
Zhanqin Zhang, Zhi Ma, Chaoying Yan, Kairui Pu, Meiyan Wu, Juan Bai, Yansong Li, Qiang Wang
The available evidence showed that mitochondrial transfer by releasing the extracellular vesicles containing mitochondria from astrocytes to neurons exerted a neuroprotective effect after stroke. Whether extracellular mitochondrial replenishment could rescue the tissues from cerebral ischemic injury still needs to be explored completely. It was hypothesized that the augmentation of mitochondrial damage after cerebral ischemia could be resolved by timely replenishment of exogenous mitochondria. A stroke model of middle cerebral artery occlusion (MCAO) was used in this study to verify this hypothesis...
September 10, 2018: Behavioural Brain Research
Jianbang Han, Zhiming Feng, Yu Xie, Feng Li, Bingke Lv, Tian Hua, Zhongfei Zhang, Chengmei Sun, Dazhuang Su, Qian Ouyang, Yingqian Cai, Yuxi Zou, Yanping Tang, Haitao Sun, Xiaodan Jiang
Bone marrow-derived mesenchymal stem cells (BMSCs) exhibit potential regenerative effects on the injured brain. However, these effects are constrained by their limited ability to migrate to the injured site. Oncostatin M (OSM) has been shown to affect the proliferation and migration of mesenchymal stem cells. Therefore, in the present study, we explored whether OSM improves BMSC migration and secretion of growth factors and cytokines in a rat middle cerebral artery occlusion (MCAO) stroke model. The effect of OSM on the proliferation and apoptosis of rat BMSCs was first assessed in vitro, and the gene and secretion levels of factors related to cell nutrition and migration, such as SDF-1 and VEGF, were detected...
September 10, 2018: Experimental Neurology
Benjamin Maïer, Perrine Boursin, Mikael Mazighi
Cerebral infarction (CI) is caused by intracranial artery occlusion. The main treatment approach is recanalisation, which is performed either medically, by intravenous thrombolysis within 4 hours and a half of the event, or by mechanical thrombectomy, which is possible up to 24 hours after CI.
September 2018: Soins; la Revue de Référence Infirmière
Elisabeth Bründl, Martin Proescholdt, Petra Schödel, Sylvia Bele, Julius Höhne, Florian Zeman, Eva-Maria Stoerr, Alexander Brawanski, Karl-Michael Schebesch
OBJECTIVES: Neuropsychological dysfunction after treatment of spontaneous subarachnoid haemorrhage (sSAH) is common but underreported. The vasoconstrictor neuropeptide Y (NPY) is excessively released after sSAH and in psychiatric disorders. We prospectively analysed the treatment-specific differences in the secretion of endogenous cerebrospinal fluid (CSF) NPY during the acute stage after sSAH and its impact on cognitive processing. METHODS: A total of 26 consecutive patients (f:m = 13:8; mean age 50...
September 14, 2018: Neurological Research
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