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head and neck pathology journal

Gabriele Corda, Arturo Sala
Cutaneous cylindroma is a rare benign tumour that occasionally turns into malignant cylindrocarcinoma. The cancer can be sporadic or emerge in the context of Brooke-Spiegler syndrome (BSS), an inheritable condition characterized by mutation of the gene CYLD, encoding a tumour suppressor protein that controls the activity of the transcription factor NF-kB. Sporadic cylindromas present histological features shared with adenoid cystic carcinoma (ACC), a head and neck cancer originating from salivary or other exocrine glands...
August 2016: Journal of Pathology
Wen-Bo Zhang, Xin Peng
Cervical treatment of oral maxillary squamous cell carcinoma (SCC) remains controversial. We determined the metastases incidence and evaluated its predictive factors. Systematic review and meta-analysis was conducted of 23 Chinese and English-language articles retrieved from PubMed, Ovid, Embase, Cochrane Library, China National Knowledge Infrastructure, and Chinese Scientific and Technological Journal databases. Total cervical metastases and occult metastases rate was 32% and 21%, respectively. Positive lymph node detection was likeliest from levels I to III...
April 2016: Head & Neck
Diane L Carlson
Andrew G. Huvos was born in communist Budapest, Hungary, in March of 1934. At twenty-four he immigrated to New York City, working as a cytotechnologist at Delafield Hospital. Dr. Huvos attended the University of Gottingen Medical School in Germany, where he was awarded his MD degree. He completed a 1-year internship at New York Hospital, going on to Residency at Delafield Hospital and Fellowship at Presbyterian Hospital. Dr. Huvos ascended through the ranks to Attending Pathologist and Member at Memorial Hospital for Cancer and Allied diseases, at Memorial Sloan-Kettering Cancer Center (MSKCC) in New York City...
March 2013: Head and Neck Pathology
Hilla Solomon, Shalom Madar, Varda Rotter
Cancer is viewed as being governed by several aberrant biological events defined by Weinberg and Hanahan as 'hallmarks'. In most human cancers the tumour suppressor p53 is mutated, leading to its malfunction and to the acquirement of oncogenic activities, termed 'gain of function'. This commentary links mutant p53 activities to the hallmarks of cancer, describing its involvement in resistance to apoptosis, genomic instability, aberrant cell cycle, invasion and metastasis, tumour microenvironment, and inflammation...
December 2011: Journal of Pathology
Jing Jing Wang, Tessa A Goldsmith, Allison S Holman, Marco Cianchetti, Annie W Chan
BACKGROUND: The purpose of this study was to report the risk of pharyngoesophageal stricture after treatment for head and neck cancer. METHODS: Human studies on radiation therapy with or without chemotherapy for head and neck cancer published in peer-reviewed journals with assessment of pharyngoesophageal stricture with barium swallow or endoscopy were included. RESULTS: A total of 4727 patients from 26 studies treated between 1989 and 2008 were eligible for analysis...
July 2012: Head & Neck
David Arnott, Michael R Emmert-Buck
The article by Roesch-Ely and colleagues in a recent issue of The Journal of Pathology describes the use of proteomic techniques to examine mucosal biopsies in patients with head and neck squamous cell cancer (HNSCC) and in corresponding control samples. The authors were able to determine the anatomical site of origin of the biopsies based on modelling of multiplex protein datasets, and to use the information to analyse field cancerization as a means of predicting tumour recurrence. Although the study included only a relatively small number of cases, and will require future validation in a larger patient cohort, the results point to the potential of proteomics to increase our understanding of cancer biology, and in this instance to offer clinical value...
September 2010: Journal of Pathology
Vishal U S Rao, Ashok M Shenoy, B Karthikeyan
Angiogenesis plays a key role in the initiation of growth and metastatic process in cancers. The angiogenic switch may be one of the earliest events in conferring a metastatic potential to the tumor. Further evolution in this multi-step cascade is controlled by the positive and negative regulators of angiogenesis. Recent advances in molecular biology have given a better insight into the mechanisms governing head neck cancer with promising data elaborating the role of angiogenesis. Metastasis to neck nodes is a very important determinant of prognosis, and is more frequently encountered than distant metastasis in head and neck cancers...
April 2010: Journal of Cancer Research and Therapeutics
P A Brennan, D A Mitchell, T W Walker, L Cascarini, R S Oeppen
The British Journal of Oral and Maxillofacial Surgery (BJOMS) accepts many types of papers that include leading articles, reviews, full length articles, and short communications. Many of the latter are isolated case reports of rare or interesting pathology, or personal experience of a difficult or unexpected complication. Case reports are considered to have a relatively low value in the advancement of medical knowledge, and with increasing pressure for space in paper publications, many journals now limit them to online publication only...
April 2010: British Journal of Oral & Maxillofacial Surgery
Yi-Shing Lisa Cheng, Harvey Kessler, David Watkins, Stephen Watson
Deep penetrating nevus is a cutaneous pigmented lesion first reported by Seab et al. in 1989. The skin of the face and neck region is one of the most common sites for deep penetrating nevus. Despite this prevalence in the head and neck region, deep penetrating nevus has not previously been discussed in journals emphasizing oral and maxillofacial pathology. The purpose of this case report is to present this rare entity to the oral pathology community, emphasizing its common presenting histologic features of a combined nevus...
July 2007: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
L S Gaspar
The syndrome of pneumomediastinum and subcutaneous emphysema is a rare and interesting complication of labour. The first case was recorded in 1784 and since that time some 200 other cases have been published. However, very little has appeared in the anaesthetic journals. This case concerns a patient who required general anaesthesia for manual removal of the placenta following a seemingly normal labour and delivery. The procedure was carried out without incident. However, as anaesthesia was being terminated it was noted that there was extensive subcutaneous emphysema over the head and neck...
January 1997: International Journal of Obstetric Anesthesia
Robert E Fechner
Surgical pathology had its beginnings in the late 1800s. A biopsy that gained much attention was from the larynx of Crown Prince Frederick in 1887. The tissue was seen by Rudolph Virchow and the clinical management of the Prince eventuated in a highly publicized furor. During the first half of the twentieth century, numerous entities in the head and neck were described by dozens of pathologists worldwide. The information was scattered in clinical journals for radiotherapists, general surgeons, and otolaryngologists...
March 2002: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
M L Gillison, K V Shah
There is increasing molecular and epidemiologic evidence that human papillomavirus (HPV) is associated with a distinct subset of head and neck squamous cell carcinomas. The strength and consistency of HPV DNA presence in oropharyngeal cancers bolster the argument that this association is likely causal. HPV-positive tonsillar cancer in particular is emerging as a specific disease entity with distinct molecular, pathologic, and clinical characteristics. Recent data suggest that the incidence of tonsillar carcinoma in the United States is increasing, despite a decline in tobacco use, supporting the existence of other important risk factors such as HPV infection...
May 2001: Current Opinion in Oncology
J Lloreta-Trull, L Ferrer, T Ribalta, M Pavesi, S Serrano
Electron microscopy (EM) is a valuable standard tool in basic research and teaching. However, its use in diagnosis is limited, either for strategic reasons or budgetary constraints. This means that its many potential applications are more often neglected, either as an ancillary tool, quality control method, or gold standard, to complement, support, or confirm results of pathological studies. To evaluate the use of EM in this setting, the authors analyzed all articles (n = 2,531) in the three top indexed diagnostic pathology journals for a period of 60 months from July 1993 to June 1998...
March 2000: Ultrastructural Pathology
D P Archer, P Ravussin
The prone position is commonly used for surgery of the spine and the posterior fossa, and is well tolerated by the majority of patients. As long as the abdomen is not compressed, the physiologic impact of this position on cardiorespiratory function is minor, in some cases even less than with the supine position. However extremes of position, particularly of the head and neck, are poorly tolerated and may lead to a variety of severe neurological complications. In addition, several specific forms of pre-existing pathology may predispose the prone patient to major cardiorespiratory complications...
1998: Annales Françaises D'anesthèsie et de Rèanimation
B Vikram
Many challenges remain, but considerable progress has been made in this field since 1983, when we published in this journal an article titled "Adjuvant Radiation Therapy in Locally Advanced Head and Neck Cancer." Several clinical and pathologic features have been identified that can stratify patients according to the risk of relapse (whether at the primary site, in the neck, or at distant sites) or the risk of second cancers, so that additional adjuvant treatment might be administered only to patients who are the most likely to benefit from it...
July 1998: CA: a Cancer Journal for Clinicians
A B Akosa, D V Nield, M N Saad
Merkel cell carcinomas are rare. The head and neck are the commonest sites of presentation. They are slightly more common in females and are frequently misdiagnosed. This tumour has had little coverage in the surgical journals which accounts for the low index of suspicion. Three cases, which were successfully treated surgically, are presented in order to increase awareness. It is a diagnosis that one should have in mind when examining an atypical skin lesion.
April 1994: British Journal of Oral & Maxillofacial Surgery
G S Hanna, M H Ali, A B Akosa, E J Maher
Merkel-Cell carcinoma is a rare malignant skin tumour. It was first described as 'Trabecular Carcinoma' by Toker in 1972. Since then many reports have appeared in the literature, mainly in the dermatology, pathology and to a lesser extent, in the plastic surgery journals. Surprisingly, the topic is rarely discussed in the otolaryngology literature, though nearly fifty per cent of these tumours arise in the head and neck.
July 1988: Journal of Laryngology and Otology
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