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https://www.readbyqxmd.com/read/28941356/computational-approaches-to-identify-genetic-interactions-for-cancer-therapeutics
#1
Graeme Benstead-Hume, Sarah K Wooller, Frances M G Pearl
The development of improved cancer therapies is frequently cited as an urgent unmet medical need. Here we describe how genetic interactions are being therapeutically exploited to identify novel targeted treatments for cancer. We discuss the current methodologies that use 'omics data to identify genetic interactions, in particular focusing on synthetic sickness lethality (SSL) and synthetic dosage lethality (SDL). We describe the experimental and computational approaches undertaken both in humans and model organisms to identify these interactions...
September 23, 2017: Journal of Integrative Bioinformatics
https://www.readbyqxmd.com/read/28938620/pathological-expression-of-tissue-factor-confers-promising-antitumor-response-to-a-novel-therapeutic-antibody-sc1-in-triple-negative-breast-cancer-and-pancreatic-adenocarcinoma
#2
Xuesai Zhang, Qingrou Li, Hui Zhao, Lanping Ma, Tao Meng, Jianchang Qian, Rui Jin, Jingkang Shen, Ker Yu
The pathological presence of tissue factor (TF) in cancer cells promotes tumor-initiated thrombosis and cancer metastasis. We found that TF is aberrantly present in large percentage of aggressive triple negative breast cancer (TNBC) and pancreatic adenocarcinoma (PaC), two most lethal forms of malignancy that urgently need effective treatment. TF expression in TNBC clustered with higher levels of vimentin, basal-type keratins KRT5/14 and caveolin-1 but lower levels of luminal-type biomarkers. We developed a novel and specific anti-TF therapeutic antibody SC1, which displayed an exceedingly high potency against TF extracellular domain (EC50: 0...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938508/-angina-pectoris-in-a-young-woman-with-lupus-erythematosus
#3
Simon Braumann, Malte P Bartram, Roman Pfister, Guido Michels
History and clinical findings We present a 31-year old woman with a 6-year history of cutaneous lupus erythematosus (CLE) who presented to the emergency room with typical chest pain. ECG and transthoracic echocardiography were normal. Her working diagnosis of pericarditis was made due to systemic progression of her lupus erythematosus (LE). Treatment with NSAIDs was initiated and her immunosuppressive regimen intensified. The patient was discharged after resolution of her symptoms. A week later, the patient was seen at the rheumatology clinic with recurrence and aggravation of her symptoms...
September 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28938024/perspectives-on-invasive-amphibians-in-brazil
#4
Lucas Rodriguez Forti, C Guilherme Becker, Leandro Tacioli, Vânia Rosa Pereira, André Cid F A Santos, Igor Oliveira, Célio F B Haddad, Luís Felipe Toledo
Introduced species have the potential to become invasive and jeopardize entire ecosystems. The success of species establishing viable populations outside their original extent depends primarily on favorable climatic conditions in the invasive ranges. Species distribution modeling (SDM) can thus be used to estimate potential habitat suitability for populations of invasive species. Here we review the status of six amphibian species with invasive populations in Brazil (four domestic species and two imported species)...
2017: PloS One
https://www.readbyqxmd.com/read/28937908/relationship-between-dental-procedures-and-shunt-infections-in-hydrocephalic-patients-a-narrative-review
#5
Chidambaram Ramasamy
Oral physicians frequently encounter medically compromised patients in their everyday practice and a sizable number of these patients are in urgent need of specialized care. One such medically specialized category is that of patients suffering from hydrocephalus. A large number of medical reports and citations in support of surgical care of the hydrocephalic disorder are available in literature. However, reports on dental studies offer contradictory statements on the relationship between hydrocephalic shunts and oral manoeuvres...
September 22, 2017: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28937886/effectiveness-of-biology-based-methods-for-inhibiting-orthodontic-tooth-movement-a-systematic-review
#6
M Cadenas de Llano-Pérula, R M Yañez-Vico, E Solano-Reina, J C Palma-Fernandez, A Iglesias-Linares
INTRODUCTION: Several experimental studies in the literature have tested different biology-based methods for inhibiting or decreasing orthodontic tooth movement (OTM) in humans. This systematic review investigated the effects of these interventions on the rate of tooth movement. STUDY DESIGN: Electronic [MedLine; SCOPUS; Cochrane Library; OpenGrey;Web of Science] and manual searches were conducted up to January 26th, 2016 in order to identify publications of clinical trials that compared the decreasing or inhibiting effects of different biology-based methods over OTM in humans...
September 22, 2017: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28937445/cervical-cancer-posttreatment-follow-up-critical-analysis
#7
Ingrid Hillesheim, Gabriel Augusto Limone, Lucia Klimann, Heleusa Monego, Marcia Appel, Alessandra de Souza, Ricardo Dos Reis
OBJECTIVE: The aim of this study was to evaluate the role of follow-up tests and examinations in diagnosing symptomatic and asymptomatic relapses after treatment for cervical cancer. METHODS: Data were collected from medical records for all patients diagnosed as having cervical cancer from January 1985 to June 2010. The significance level was P < 0.005. RESULTS: Sixty-four (17.8%) of the 358 patients investigated suffered tumor relapse...
October 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28936609/a-hierarchical-testing-strategy-for-micropollutants-in-drinking-water-regarding-their-potential-endocrine-disrupting-effects-towards-health-related-indicator-values
#8
Jochen Kuckelkorn, Regine Redelstein, Timon Heide, Jennifer Kunze, Sibylle Maletz, Petra Waldmann, Tamara Grummt, Thomas-Benjamin Seiler, Henner Hollert
In Germany, micropollutants that (may) occur in drinking water are assessed by means of the health-related indicator value (HRIV concept), developed by the German Federal Environment Agency. This concept offers five threshold values (≤ 0.01 to ≤ 3 μg l(-1)) depending on availability and completeness of data regarding genotoxicity, neurotoxicity, and germ cell-damaging potential. However, the HRIV concept is yet lacking integration of endocrine disruptors as one of the most prominent toxicological concerns in water bodies, including drinking water...
September 21, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28936545/open-tracheostomy-training-a-nationwide-survey-among-otolaryngology-head-and-neck-surgery-residents
#9
Limor Muallem-Kalmovich, Jacob Pitaro, Ayman Asaly, Alex Kessler, Ephraim Eviatar, Moran Shteiner, Tal Marom
The aim of this study was to examine the training methods and needs of Otolaryngology-Head and Neck Surgery (OTO-HNS) residents to independently perform open tracheostomy (OT). An anonymous 26-items questionnaire pertaining to OT teaching aspects was distributed to all 93 Israeli OTO-HNS residents during March-June 2016. Residents were categorized as 'juniors,' if they were in their post-graduate year (PGY)-1 and PGY-2; 'mid-residency' (PGY-3 and PGY-4); or 'seniors' (PGY-5 and PGY-6). Response rate was 74% (n = 69)...
September 21, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28936377/not-a-common-rectosigmoid-perforation
#10
Rizwan Ishtiaq, Khurram Niaz, Darakshan Masood, Daniyal Ishtiaq, Shafay Yasin, Umer H Chaudhry, Anam Ashraf
Gastrointestinal perforation is a common complication arising due to homicidal injuries, trauma or intake of medications like aspirin. Intestinal perforation caused by chronic intake of mud, clay or soil is a rare phenomenon and very few cases have been reported in the literature. We hereby present the first case of rectosigmoid perforation from Pakistan which was caused by chronic mud intake in a female patient. Diagnosis of this condition in its early stage is important because it can be fatal if not addressed urgently...
July 13, 2017: Curēus
https://www.readbyqxmd.com/read/28936070/traumatic-cerrebral-fungus-experience-from-an-institution-in-north-east-india
#11
Binoy Kumar Singh, Abinash Dutta, Shameem Ahmed, Zakir Hussain, Rajib Hazarika, Bineta Singh
BACKGROUND: Traumatic brain fungus is manifestation of neglected head injury. Although rare it is not uncommon. The patients are usually intact with good Glasgow coma (GCS) score inspite of complex injuries and exposed brain parenchyma but morbidity and mortality is very high with time if no proper and timely management is offered. There is very less study on traumatic brain fungus with no defined management protocols. So an attempt was made to explain in details the surgical strategies and other management techniques in patients with traumatic brain fungus...
August 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28935938/an-engineered-bispecific-dna-encoded-igg-antibody-protects-against-pseudomonas-aeruginosa-in-a-pneumonia-challenge-model
#12
Ami Patel, Antonio DiGiandomenico, Ashley E Keller, Trevor R F Smith, Daniel H Park, Stephanie Ramos, Katherine Schultheis, Sarah T C Elliott, Janess Mendoza, Kate E Broderick, Megan C Wise, Jian Yan, Jingjing Jiang, Seleeke Flingai, Amir S Khan, Kar Muthumani, Laurent Humeau, Lily I Cheng, Leslie Wachter-Rosati, C Kendall Stover, Niranjan Y Sardesai, David B Weiner
The impact of broad-spectrum antibiotics on antimicrobial resistance and disruption of the beneficial microbiome compels the urgent investigation of bacteria-specific approaches such as antibody-based strategies. Among these, DNA-delivered monoclonal antibodies (DMAbs), produced by muscle cells in vivo, potentially allow the prevention or treatment of bacterial infections circumventing some of the hurdles of protein IgG delivery. Here, we optimize DNA-delivered monoclonal antibodies consisting of two potent human IgG clones, including a non-natural bispecific IgG1 candidate, targeting Pseudomonas aeruginosa...
September 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/28935918/host-directed-therapies-for-bacterial-and-viral-infections
#13
REVIEW
Stefan H E Kaufmann, Anca Dorhoi, Richard S Hotchkiss, Ralf Bartenschlager
Despite the recent increase in the development of antivirals and antibiotics, antimicrobial resistance and the lack of broad-spectrum virus-targeting drugs are still important issues and additional alternative approaches to treat infectious diseases are urgently needed. Host-directed therapy (HDT) is an emerging approach in the field of anti-infectives. The strategy behind HDT is to interfere with host cell factors that are required by a pathogen for replication or persistence, to enhance protective immune responses against a pathogen, to reduce exacerbated inflammation and to balance immune reactivity at sites of pathology...
September 22, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28935900/antibacterial-and-immunomodulatory-activities-of-insect-defensins-dlp2-and-dlp4-against-multidrug-resistant-staphylococcus-aureus
#14
Zhanzhan Li, Ruoyu Mao, Da Teng, Ya Hao, Huixian Chen, Xiumin Wang, Xiao Wang, Na Yang, Jianhua Wang
Methicillin-resistant Staphylococcus aureus (MRSA), are the most frequent cause of sepsis, which urgently demanding new drugs for treating infection. Two homologous insect CSαβ peptides-DLP2 and DLP4 from Hermetia illucens were firstly expressed in Pichia pastoris, with the yields of 873.5 and 801.3 mg/l, respectively. DLP2 and DLP4 displayed potent antimicrobial activity against Gram-positive bacteria especially MRSA and had greater potency, faster killing, and a longer postantibiotic effect than vancomycin...
September 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28935860/secular-trends-in-overweight-and-obesity-among-urban-children-and-adolescents-2003-2012-a-serial-cross-sectional-study-in-guangzhou-china
#15
Yinan Zong, Runsheng Xie, Nali Deng, Li Liu, Weiqing Tan, Yanhui Gao, Jiewen Yang, Yi Yang
Childhood and adolescent overweight and obesity are increasing in China, but limited information is available on its secular trends in Guangzhou. In this cross-sectional study, ten-wave successive data were obtained from the physical fitness surveillance for students in Guangzhou from 2003 to 2012. A total of 2,619,154 urban students aged 7-18 years were included. The age-standardized prevalence of overweight and obesity increased significantly over the period: overweight rose from 10.15% to 14.07% in boys and 6...
September 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28935858/modular-fluorescence-complementation-sensors-for-live-cell-detection-of-epigenetic-signals-at-endogenous-genomic-sites
#16
Cristiana Lungu, Sabine Pinter, Julian Broche, Philipp Rathert, Albert Jeltsch
Investigation of the fundamental role of epigenetic processes requires methods for the locus-specific detection of epigenetic modifications in living cells. Here, we address this urgent demand by developing four modular fluorescence complementation-based epigenetic biosensors for live-cell microscopy applications. These tools combine engineered DNA-binding proteins with domains recognizing defined epigenetic marks, both fused to non-fluorescent fragments of a fluorescent protein. The presence of the epigenetic mark at the target DNA sequence leads to the reconstitution of a functional fluorophore...
September 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/28935631/cultural-crossings-of-care-an-appeal-to-the-medical-humanities
#17
Julia Kristeva, Marie Rose Moro, John Ødemark, Eivind Engebretsen
Modern medicine is confronted with cultural crossings in various forms. In facing these challenges, it is not enough to simply increase our insight into the cultural dimensions of health and well-being. We must, more radically, question the conventional distinction between the 'objectivity of science' and the 'subjectivity of culture'. This obligation creates an urgent call for the medical humanities but also for a fundamental rethinking of their grounding assumptions.Julia Kristeva (JK) has problematised the biomedical concept of health through her reading of the anthropogony of Cura (Care), who according to the Roman myth created man out of a piece of clay...
September 21, 2017: Medical Humanities
https://www.readbyqxmd.com/read/28935282/the-prudent-layperson-s-complicated-and-uncertain-road-to-urgent-care
#18
EDITORIAL
Michael L Callaham
No abstract text is available yet for this article.
September 18, 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/28935277/comparing-freestanding-emergency-departments-hospital-based-emergency-departments-and-urgent-care-in-texas-apples-oranges-or-lemons
#19
EDITORIAL
Jeremiah D Schuur, Donald M Yealy, Michael L Callaham
No abstract text is available yet for this article.
September 18, 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/28935107/glycoengineered-outer-membrane-vesicles-as-a-platform-for-vaccine-development
#20
Ezequiel Valguarnera, Mario F Feldman
As we enter into the postantibiotic era, vaccines to prevent bacterial infections previously treatable with antibiotics are urgently needed. Most successful antibacterial vaccines are glycoconjugates, composed of cell surface carbohydrates chemically attached to a carrier protein. Glycoconjugate vaccines provide a safe and consistent strategy against polysaccharide-encapsulated pathogens. The best examples are the conjugate vaccines against Haemophilus influenzae type b, Streptococcus pneumoniae, and Neisseria meningitidis, all based on capsular polysaccharides...
2017: Methods in Enzymology
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