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N-acetylaspartate AND glutamine

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https://www.readbyqxmd.com/read/29904952/baicalin-effects-on-rats-with-spinal-cord-injury-by-anti-inflammatory-and-regulating-the-serum-metabolic-disorder
#1
Shufeng Kang, Shizhao Liu, Hongzhu Li, Dapeng Wang, Xiangbei Qi
Baicalin had neuroprotective effects on inhibiting neuronal cell apoptosis induced by spinal cord ischemic injury. This study aimed to explore the protective effects of Baicalin on rats with spinal cord injury (SCI) and its mechanism of action. The recovery of spinal cord nerve function in rats was evaluated by the Basso, Beattie, and Bresnahan (BBB) score and the combine behavioral score (CBS). The expressions of cytokines tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β), and IL-6 were detected by the enzyme-linked immunosorbent assay method...
June 15, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29893645/changes-in-brain-metabolite-concentrations-after-neonatal-hypoxic-ischemic-encephalopathy
#2
Jun Shibasaki, Noriko Aida, Naho Morisaki, Moyoko Tomiyasu, Yuri Nishi, Katsuaki Toyoshima
Purpose To investigate the time-course changes and predictive utility of brain metabolite concentrations in neonatal hypoxic-ischemic encephalopathy (HIE). Materials and Methods Sixty-eight neonates (age, 35-41 gestational weeks) with HIE were admitted to a neonatal intensive care unit between September 2009 and March 2016 and examined by using proton MR spectroscopy at 18-96 hours (n = 25) and 7-14 days (n = 64) after birth (35-43 postmenstrual weeks) to estimate metabolite concentrations in the deep gray matter...
June 12, 2018: Radiology
https://www.readbyqxmd.com/read/29860500/intralipid-heparin-infusion-alters-the-brain-metabolites-assessed-with-1h-mrs-spectroscopy-in-young-healthy-men
#3
Monika Karczewska-Kupczewska, Agnieszka Nikolajuk, Remigiusz Filarski, Radoslaw Majewski, Eugeniusz Tarasów
Context: We previously demonstrated that insulin infusion altered the metabolite concentrations in cerebral tissues, assessed with proton magnetic resonance spectroscopy (1H-MRS) in young subjects with high insulin sensitivity, but not with low insulin sensitivity. Fat overload is an important factor leading to insulin resistance. Objective: The purpose of the present study was to examine the effect of circulating free fatty acids (FFA) elevation on the metabolites in cerebral tissues, assessed with 1H-MRS...
April 20, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29773892/metabolite-cycled-density-weighted-concentric-rings-k-space-trajectory-dw-crt-enables-high-resolution-1-h-magnetic-resonance-spectroscopic-imaging-at-3-tesla
#4
Adam Steel, Mark Chiew, Peter Jezzard, Natalie L Voets, Puneet Plaha, Michael Albert Thomas, Charlotte J Stagg, Uzay E Emir
Magnetic resonance spectroscopic imaging (MRSI) is a promising technique in both experimental and clinical settings. However, to date, MRSI has been hampered by prohibitively long acquisition times and artifacts caused by subject motion and hardware-related frequency drift. In the present study, we demonstrate that density weighted concentric ring trajectory (DW-CRT) k-space sampling in combination with semi-LASER excitation and metabolite-cycling enables high-resolution MRSI data to be rapidly acquired at 3 Tesla...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29752742/j-difference-edited-mrs-measures-of-%C3%AE-aminobutyric-acid-before-and-after-acute-caffeine-administration
#5
Georg Oeltzschner, Helge J Zöllner, Marc Jonuscheit, Rotem S Lanzman, Alfons Schnitzler, Hans-Jörg Wittsack
PURPOSE: The aim of this study was to investigate potential effects of acute caffeine intake on J-difference-edited MRS measures of the primary inhibitory neurotransmitter γ-aminobutyric acid (GABA). METHODS: J-difference-edited Mescher-Garwood PRESS (MEGA-PRESS) and conventional PRESS data were acquired at 3T from voxels in the anterior cingulate and occipital area of the brain in 15 healthy subjects, before and after oral intake of a 200-mg caffeine dose. MEGA-PRESS data were analyzed with the MATLAB-based Gannet tool to estimate GABA+ macromolecule (GABA+) levels, while PRESS data were analyzed with LCModel to estimate levels of glutamate, glutamate+glutamine, N-acetylaspartate, and myo-inositol...
May 12, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29713308/-in-vivo-multimodal-magnetic-resonance-imaging-changes-after-n-methyl-d-aspartate-triggered-spasms-in-infant-rats
#6
Minyoung Lee, Mi-Sun Yum, Dong-Cheol Woo, Woo-Hyun Shim, Tae-Sung Ko, Libor Velíšek
Objective: Despite the serious neurodevelopmental sequelae of epileptic encephalopathy during infancy, the pathomechanisms involved remain unclear. To find potential biomarkers that can reflect the pathogenesis of epileptic encephalopathy, we explored the neurometabolic and microstructural sequelae after infantile spasms using a rat model of infantile spasms and in vivo magnetic resonance imaging techniques. Methods: Rats prenatally exposed to betamethasone were subjected to three rounds of intraperitoneal N -methyl-d-aspartate (NMDA) triggering of spasms or received saline injections (controls) on postnatal days (P) 12, 13, and 15...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29706886/lower-choline-and-myo-inositol-in-temporo-parietal-cortex-is-associated-with-apathy-in-amnestic-mci
#7
Shankar Tumati, Esther M Opmeer, Jan-Bernard C Marsman, Sander Martens, Fransje E Reesink, Peter P De Deyn, André Aleman
Apathy is a common symptom in patients with amnestic mild cognitive impairment (aMCI) and is associated with an increased risk of progression to Alzheimer's disease (AD). The neural substrates underlying apathy in aMCI may involve multiple brain regions, including the anterior cingulate cortex and the temporo-parietal region. Here we investigated neurometabolites in brain regions that may underlie apathy in aMCI patients using proton magnetic resonance spectroscopy (1 H-MRS). Twenty-eight aMCI patients with varying degrees of apathy and 20 matched controls underwent 1 H-MRS...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29651419/management-of-glioblastoma-multiforme-in-a-patient-treated-with-ketogenic-metabolic-therapy-and-modified-standard-of-care-a-24-month-follow-up
#8
Ahmed M A Elsakka, Mohamed Abdel Bary, Eman Abdelzaher, Mostafa Elnaggar, Miriam Kalamian, Purna Mukherjee, Thomas N Seyfried
Few advances have been made in overall survival for glioblastoma multiforme (GBM) in more than 40 years. Here, we report the case of a 38-year-old man who presented with chronic headache, nausea, and vomiting accompanied by left partial motor seizures and upper left limb weakness. Enhanced brain magnetic resonance imaging revealed a solid cystic lesion in the right partial space suggesting GBM. Serum testing revealed vitamin D deficiency and elevated levels of insulin and triglycerides. Prior to subtotal tumor resection and standard of care (SOC), the patient conducted a 72-h water-only fast...
2018: Frontiers in Nutrition
https://www.readbyqxmd.com/read/29587752/alzheimer-like-brain-metabolic-and-structural-features-in-cholesterol-fed-rabbit-detected-by-magnetic-resonance-imaging
#9
Ping Jin, Yongming Pan, Zhiyong Pan, Jianqin Xu, Min Lin, Zhichao Sun, Minli Chen, Maosheng Xu
BACKGROUND: Hypercholesterolemia is known to increase the risk of AD in later life, the purpose of this study is to illustrate brain metabolic and structural changes in a cholesterol-fed rabbit model of Alzheimer's Disease (AD) by using clinical 3 T Magnetic Resonance Imaging (MRI). METHODS: The Institutional Animal Care and Use Committee of Zhejiang Chinese Medical University approved the study. Totally 16 Japanese White Rabbits (JWR) were randomly divided into 2 groups including normal control group fed with routine diet (group NC) and high cholesterol diet group (group CD) fed a 2% cholesterol diet with 0...
March 27, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29580804/neurometabolite-levels-in-antipsychotic-na%C3%A3-ve-free-patients-with-schizophrenia-a-systematic-review-and-meta-analysis-of-1-h-mrs-studies
#10
REVIEW
Yusuke Iwata, Shinichiro Nakajima, Eric Plitman, Yukiko Mihashi, Fernando Caravaggio, Jun Ku Chung, Julia Kim, Philip Gerretsen, Masaru Mimura, Gary Remington, Ariel Graff-Guerrero
BACKGROUND: Studies using proton magnetic resonance spectroscopy (1 H-MRS) have reported altered neurometabolite levels in patients with schizophrenia. However, results are possibly confounded by the influence of antipsychotic (AP). Thus, this meta-analysis aimed to examine neurometabolite levels in AP-naïve/free patients with schizophrenia. METHODS: A literature search was conducted using Embase, Medline, and PsycINFO to identify studies that compared neurometabolite levels in AP-naïve/free patients with schizophrenia to healthy controls (HCs)...
March 23, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29541417/metabolic-profiling-of-the-three-neural-derived-embryonal-pediatric-tumors-retinoblastoma-neuroblastoma-and-medulloblastoma-identifies-distinct-metabolic-profiles
#11
Sarah E Kohe, Christopher D Bennett, Simrandip K Gill, Martin Wilson, Carmel McConville, Andrew C Peet
The rare pediatric embryonal tumors retinoblastoma, medulloblastoma and neuroblastoma derive from neuroectodermal tissue and share similar histopathological features despite different anatomical locations and diverse clinical outcomes. As metabolism can reflect genetic and histological features, we investigated whether the metabolism of embryonal tumors reflects their similar histology, shared developmental and neural origins, or tumor location. We undertook metabolic profiling on 50 retinoblastoma, 39 medulloblastoma and 70 neuroblastoma using high resolution magic angle spinning magnetic resonance spectroscopy (1H-MRS)...
February 16, 2018: Oncotarget
https://www.readbyqxmd.com/read/29530754/investigating-the-metabolic-alterations-in-a-depressive-like-rat-model-of-chronic-forced-swim-stress-an-in-vivo-proton-magnetic-resonance-spectroscopy-study-at-7t
#12
Chi-Hyeon Yoo, Song-I Lim, Kyu-Ho Song, Dong-Cheol Woo, Bo-Young Choe
Although recent investigations of major depressive disorder (MDD) have focused on the monoaminergic system, accumulating evidences suggest that alternative pathophysiological models of MDD and treatment options for patients with MDD are needed. Animals subjected to chronic forced swim stress (CFSS) develop behavioral despair. The purpose of this study was to investigate the in vivo effects of CFSS on systems other than the monoamine system in the rat prefrontal cortex (PFC) with 7T and short-echo-time (16...
June 2018: Neurochemistry International
https://www.readbyqxmd.com/read/29515360/metabolic-disturbances-in-the-striatum-and-substantia-nigra-in-the-onset-and-progression-of-mptp-induced-parkinsonism-model
#13
Yi Lu, Xiaoxia Zhang, Liangcai Zhao, Changwei Yang, Linlin Pan, Chen Li, Kun Liu, Guanghui Bai, Hongchang Gao, Zhihan Yan
Metabolic confusion has been linked to the pathogenesis of Parkinson's disease (PD), while the dynamic changes associated with the onset and progression of PD remain unclear. Herein, dynamic changes in metabolites were detected from the initiation to the development of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) -induced Parkinsonism model to elucidate its potential metabolic mechanism. Ex vivo 1 H nuclear magnetic resonance (NMR) spectroscopy was used to measure metabolite changes in the striatum and substantia nigra (SN) of mice at 1, 7, and 21 days after injection of MPTP...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29511334/psychostimulant-drug-effects-on-glutamate-glx-and-creatine-in-the-anterior-cingulate-cortex-and-subjective-response-in-healthy-humans
#14
Tara L White, Mollie A Monnig, Edward G Walsh, Adam Z Nitenson, Ashley D Harris, Ronald A Cohen, Eric C Porges, Adam J Woods, Damon G Lamb, Chelsea A Boyd, Sinda Fekir
Prescription psychostimulants produce rapid changes in mood, energy, and attention. These drugs are widely used and abused. However, their effects in human neocortex on glutamate and glutamine (pooled as Glx), and key neurometabolites such as N-acetylaspartate (tNAA), creatine (tCr), choline (Cho), and myo-inositol (Ins) are poorly understood. Changes in these compounds could inform the mechanism of action of psychostimulant drugs and their abuse potential in humans. We investigated the acute impact of two FDA-approved psychostimulant drugs on neurometabolites using magnetic resonance spectroscopy (1 H MRS)...
June 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29506576/effects-of-isoflurane-sevoflurane-propofol-and-alfaxalone-on-brain-metabolism-in-dogs-assessed-by-proton-magnetic-resonance-spectroscopy-1-h-mrs
#15
Franz Josef Söbbeler, Inés Carrera, Kirby Pasloske, Millagahamada Gedara Ranasinghe, Patrick Kircher, Sabine Beate Rita Kästner
BACKGROUND: The purpose of this study was to determine the effects of isoflurane, sevoflurane, propofol and alfaxalone on the canine brain metabolite bioprofile, measured with single voxel short echo time proton magnetic resonance spectroscopy at 3 Tesla. Ten adult healthy Beagle dogs were assigned to receive isoflurane, sevoflurane, propofol and alfaxalone at 3 different dose rates each in a randomized cross-over study design. Doses for isoflurane, sevoflurane, propofol and alfaxalone were FE 'Iso 1...
March 5, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29414127/striatal-neurometabolite-levels-in-patients-with-schizophrenia-undergoing-long-term-antipsychotic-treatment-a-proton-magnetic-resonance-spectroscopy-and-reliability-study
#16
Eric Plitman, Sofia Chavez, Shinichiro Nakajima, Yusuke Iwata, Jun Ku Chung, Fernando Caravaggio, Julia Kim, Youssef Alshehri, M Mallar Chakravarty, Vincenzo De Luca, Gary Remington, Philip Gerretsen, Ariel Graff-Guerrero
Previous proton magnetic resonance spectroscopy (1 H-MRS) studies have reported disrupted levels of various neurometabolites in patients with schizophrenia. An area of particular interest within this patient population is the striatum, which is highly implicated in the pathophysiology of schizophrenia. The present study examined neurometabolite levels in the striatum of 12 patients with schizophrenia receiving antipsychotic treatment for at least 1 year and 11 healthy controls using 3-Tesla 1 H-MRS (PRESS, TE = 35 ms)...
March 30, 2018: Psychiatry research. Neuroimaging
https://www.readbyqxmd.com/read/29414126/proton-magnetic-resonance-spectroscopy-changes-after-lithium-treatment-systematic-review
#17
REVIEW
Agata Szulc, Magdalena Wiedlocha, Napoleon Waszkiewicz, Beata Galińska-Skok, Piotr Marcinowicz, Jacek Gierus, Anna Mosiolek
1H MRS is widely used in the research of mental disorders. It enables evaluation of concentration or ratios of several metabolites, which play important roles in brain metabolism: N-acetylaspartate (NAA), choline containing compounds, myo-inositol and glutamate, glutamine and GABA (together as Glx complex or separately). Specifically in bipolar disorder brain metabolite abnormalities include mostly NAA reduces and Glx increases in different brain regions. Bipolar disorder is associated with impairment in neurotrophic and cellular plasticity, resilience pathways and in neuroprotective processes...
March 30, 2018: Psychiatry research. Neuroimaging
https://www.readbyqxmd.com/read/29391242/sex-and-sex-hormone-related-variations-in-energy-metabolic-frontal-brain-asymmetries-a-magnetic-resonance-spectroscopy-study
#18
Helene Hjelmervik, Markus Hausmann, Alexander R Craven, Marco Hirnstein, Kenneth Hugdahl, Karsten Specht
Creatine is a key regulator of brain energy homeostasis, and well-balanced creatine metabolism is central in healthy brain functioning. Still, the variability of brain creatine metabolism is largely unattended in magnetic resonance spectroscopy (MRS) research. In the human brain, marginal sex differences in creatine levels have been found in the prefrontal cortex. It is however not known to what degree these sex differences are stable or change with varying gonadal hormone levels. The current study therefore investigated creatine in the prefrontal cortex across the menstrual cycle...
May 15, 2018: NeuroImage
https://www.readbyqxmd.com/read/29385594/7t-proton-magnetic-resonance-spectroscopy-of-the-anterior-cingulate-cortex-in-first-episode-schizophrenia
#19
Meredith A Reid, Nouha Salibi, David M White, Timothy J Gawne, Thomas S Denney, Adrienne C Lahti
Recent magnetic resonance spectroscopy (MRS) studies suggest that abnormalities of the glutamatergic system in schizophrenia may be dependent on illness stage, medication status, and symptomatology. Glutamatergic metabolites appear to be elevated in the prodromal and early stages of schizophrenia but unchanged or reduced below normal in chronic, medicated patients. However, few of these studies have measured metabolites with high-field 7T MR scanners, which offer higher signal-to-noise ratio and better spectral resolution than 3T scanners and facilitate separation of glutamate and glutamine into distinct signals...
January 29, 2018: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29377412/high-fat-diet-induces-a-neurometabolic-state-characterized-by-changes-in-glutamate-and-n-acetylaspartate-pools-associated-with-early-glucose-intolerance-an-in-vivo-multimodal-mri-study
#20
Mário Ribeiro, João Castelhano, Lorena I Petrella, José Sereno, Tiago Rodrigues, Christian Neves, Liliana Letra, Filipa I Baptista, Raquel Seiça, Paulo Matafome, Miguel Castelo-Branco
BACKGROUND: Type-2 diabetes mellitus (T2DM) is a metabolic disorder with a broad range of complications in the brain that depend on the conditions that precede its onset, such as obesity and metabolic syndromes. It has been suggested that neurotransmitter and metabolic perturbations may emerge even before the early stages of T2DM and that high-caloric intake could adversely influence the brain in such states. Notwithstanding, evidence for neurochemical and structural alterations in these conditions are still sparse and controversial...
January 26, 2018: Journal of Magnetic Resonance Imaging: JMRI
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