Bingli Zhang, Yizhou Zhong, Jiaxin Du, Rongyi Ye, Bingchi Fan, Yanhong Deng, Ruobing Bai, Yu Feng, Xiaohong Yang, Yuji Huang, Boxuan Liang, Jiewei Zheng, Weifeng Rong, Xingfen Yang, Zhenlie Huang
1,2-Dichloroethane (1,2-DCE) is a prevalent environmental contaminant, and our study revealed its induction of testicular toxicity in mice upon subacute exposure. Melatonin, a prominent secretory product of the pineal gland, has been shown to offer protection against pyroptosis in male reproductive toxicity. However, the exact mechanism underlying 1,2-DCE-induced testicular toxicity and the comprehensive extent of melatonin's protective effects in this regard remain largely unexplored. Therefore, we sequenced testis piRNAs in mice exposed to environmentally relevant concentrations of 1,2-DCE by 28-day dynamic inhalation, and investigated the role of key piRNAs using GC-2 spd cells...
February 9, 2024: Environment International