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https://www.readbyqxmd.com/read/28212582/the-association-of-pretreatment-thrombocytosis-with-prognosis-and-clinicopathological-significance-in-cervical-cancer-a-systematic-review-and-meta-analysis
#1
Juan Cheng, Zhi Zeng, Qingjian Ye, Yu Zhang, Ronghua Yan, Changyan Liang, Jia Wang, Mengxiong Li, Mixuan Yi
Previous studies reported inconsistent findings about the relationship between pretreatment thrombocytosis and survival in patients with cervical cancer. This study aimed to evaluate the prognostic significance of thrombocytosis in cervical cancer. We searched databases to identify relevant articles. Pooled hazard ratios (HRs), odds ratios (ORs), and 95% confidence intervals (CIs) were calculated. Fourteen studies including 3,394 patients were eligible for the meta-analysis. Overall, an elevated platelet count was significantly associated with inferior overall survival (OS, hazard ratio [HR]: 1...
February 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28212531/msmb-gene-rs10993994-polymorphism-increases-the-risk-of-prostate-cancer
#2
Tao Peng, Lifeng Zhang, Lijie Zhu, Yuan-Yuan Mi
Genome-wide association studies (GWASs) identified microseminoprotein-β (MSMB) gene rs10993994 polymorphism was significantly associated with prostate cancer (PC) risk. However, the association between MSMB gene rs10993994 polymorphism and PC risk remains controversial. Therefore, we performed a systematic review and meta-analysis by searching in the databases of PubMed, and Embase. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by using fixed-effect or random-effect models. A total of 11 publications containing 13 case-control studies for rs10993994 polymorphism were included in our analysis...
February 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28212466/withdrawn-propranolol-for-migraine-prophylaxis
#3
REVIEW
Klaus Linde, Karin Rossnagel
BACKGROUND: Propranolol is one of the most commonly prescribed drugs for migraine prophylaxis. OBJECTIVES: We aimed to determine whether there is evidence that propranolol is more effective than placebo and as effective as other drugs for the interval (prophylactic) treatment of patients with migraine. SEARCH METHODS: Potentially eligible studies were identified by searching MEDLINE/PubMed (1966 to May 2003) and the Cochrane Central Register of Controlled Trials (Issue 2, 2003), and by screening bibliographies of reviews and identified articles...
February 17, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28212434/prognostic-and-clinicopathological-value-of-poly-adenosine-diphosphate-ribose-polymerase-expression-in-breast-cancer-a-meta-analysis
#4
Weiqiang Qiao, Linlin Pan, Changgui Kou, Ke Li, Ming Yang
BACKGROUND: Previous studies have shown that the poly (adenosine diphosphate-ribose) polymerase (PARP) level is a promising indicator of breast cancer. However, its prognostic value remains controversial. The present meta-analysis evaluated the prognostic value of PARP expression in breast cancer. MATERIALS AND METHODS: Eligible studies were retrieved from the PubMed, Web of Science, Embase, and Cochrane Library databases through July 20, 2016. Studies investigating PARP expression as well as reporting survival data in breast cancer were included...
2017: PloS One
https://www.readbyqxmd.com/read/28212414/decline-in-infection-related-morbidities-following-drug-mediated-reductions-in-the-intensity-of-schistosoma-infection-a-systematic-review-and-meta-analysis
#5
Gisele Andrade, David J Bertsch, Andrea Gazzinelli, Charles H King
BACKGROUND: Since 1984, WHO has endorsed drug treatment to reduce Schistosoma infection and its consequent morbidity. Cross-sectional studies suggest pre-treatment correlation between infection intensity and risk for Schistosoma-related pathology. However, evidence also suggests that post-treatment reduction in intensity may not reverse morbidity because some morbidities occur at all levels of infection, and some reflect permanent tissue damage. The aim of this project was to systematically review evidence on drug-based control of schistosomiasis and to develop a quantitative estimate of the impact of post-treatment reductions in infection intensity on prevalence of infection-associated morbidity...
February 17, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28212307/antiretroviral-treatment-in-hiv-1-positive-mothers-neurological-implications-in-virus-free-children
#6
REVIEW
Antonio Victor Campos Coelho, Paola Maura Tricarico, Fulvio Celsi, Sergio Crovella
Since the worldwide introduction of antiretroviral therapy (ART) in human immunodeficiency virus type 1, HIV-1-positive mothers, together with HIV-1 testing prior to pregnancy, caesarian birth and breastfeeding cessation with replacement feeding, a reduction of HIV-1 mother-to-child transmission (MTCT) has been observed in the last few years. As such, an increasing number of children are being exposed in utero to ART. Several questions have arisen concerning the neurological effects of ART exposure in utero, considering the potential effect of antiretroviral drugs on the central nervous system, a structure which is in continuous development in the fetus and characterized by great plasticity...
February 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28212260/laparoscopic-approach-in-colonic-diverticulitis-dispelling-myths-and-misperceptions
#7
Panagiota Gralista, Demetrios Moris, Michail Vailas, Anastasios Angelou, Athanasios Petrou, Evangelos Felekouras, Alexandros Papalampros
BACKGROUND/AIM: Diverticular disease is a first-class health care problem and one of the most common gastrointestinal disorders in western industrialized countries, causing significant morbidity and mortality. In this review of the literature, we aim to assess the feasibility and effectiveness of the laparoscopic approach in both elective and emergency setting of diverticular disease. MATERIALS AND METHODS: A bibliographic search of articles was performed using the electronic database Medline from PubMed...
February 16, 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/28212192/genetic-control-of-erythropoiesis
#8
Laxminath Tumburu, Swee Lay Thein
PURPOSE OF REVIEW: The discovery of several genetic variants associated with erythroid traits and subsequent elucidation of their functional mechanisms are exemplars of the power of the new genetic and genomic technology. The present review highlights findings from recent genetic studies related to the control of erythropoiesis and dyserythropoiesis, and fetal hemoglobin, an erythroid-related trait. RECENT FINDINGS: Identification of the genetic modulators of erythropoiesis involved two approaches: genome-wide association studies (GWASs) using single nucleotide polymorphism (SNP) arrays that revealed the common genetic variants associated with erythroid phenotypes (hemoglobin, red cell count, MCV, MCH) and fetal hemoglobin; and massive parallel sequencing such as whole genome sequencing (WGS) and whole exome sequencing (WES) that led to the discovery of the rarer variants (GFI1B, SBDS, RPS19, PKLR, EPO, EPOR, KLF1, GATA1)...
February 15, 2017: Current Opinion in Hematology
https://www.readbyqxmd.com/read/28211819/improved-functions-and-reduced-length-of-stay-after-inpatient-rehabilitation-programs-in-older-adults-with-stroke-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#9
Saad M Bindawas, Vishal Vennu, Emad Moftah
BACKGROUND: to examine the effects of inpatient rehabilitation programs on function and length of stay in older adults with strokeMETHODS: A total of five electronic databases were searched for relevant randomized controlled trials that examined the effects of inpatient rehabilitation programs on functional recovery, as measured by the functional independence measure and length of stay, which was measured in days. We included full-text articles written in English, and no time limit. The methodological quality and risk of bias were assessed using the Physiotherapy Evidence Database Scale and the Cochrane collaboration tools respectively...
February 15, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28211818/comparison-of-the-effects-of-bilateral-and-unilateral-training-after-stroke-a-meta-analysis
#10
Yejin Lee, Moon Young Kim, Ji-Hyuk Park, Hae Yean Park
BACKGROUND: The differential effects of bilateral and unilateral training on upper extremity (UE) function remain unclear. OBJECTIVE: To compare the effectiveness of bilateral and unilateral training on UE function and activities of daily living (ADL) after stroke. METHODS: Randomized controlled trials (RCTs) were selected for inclusion by two reviewers after searching the following databases: MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), and KoreaMed...
February 15, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28211499/the-prognostic-value-of-cytotoxic-t-lymphocyte-antigen-4-in-cancers-a-systematic-review-and-meta-analysis
#11
Pingping Hu, Qiqi Liu, Guodong Deng, Jingxin Zhang, Ning Liang, Jian Xie, Jiandong Zhang
The outcomes of studies analyzing the prognostic role of CTLA-4 in cancers are controversial. Therefore, the aim of our meta-analysis was to clarify the correlation between CTLA-4 expression and OS in different cancer cases. Relevant literature was searched using PubMed, EMBASE, Web of Science, and the Cochrane Library. The clinicopathological features, hazard ratio (HR) and 95% confidence intervals (CI) were collected from these studies and were analyzed using Stata version 12.0 software. The pooled HR values showed no significant correlation between CTLA-4 expression levels and OS in relation to tumors (HR: 1...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28211286/systematic-review-on-risk-factors-of-rotator-cuff-tears
#12
Andrew Arjun Sayampanathan, Tan Hwee Chye Andrew
PURPOSE: Rotator cuff tears (RCTs) occur commonly, especially among certain groups of individuals. In this meta-analysis, we aim to identify risk factors for RCTs. METHODS: We searched MEDLINE for 210 articles. Seventeen articles were selected for systematic review, of which 10 were eligible for meta-analysis. Data was analysed with Review Manager 5.3, using Mantel-Haenszel statistics and random effect models. RESULTS: A total of 6653 individuals were analysed...
January 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28211200/the-interrelation-between-hypothyroidism-and-glaucoma-a-critical-review-and-meta-analyses
#13
REVIEW
Marianne Thvilum, Frans Brandt, Thomas Heiberg Brix, Laszlo Hegedüs
Data on the association between hypothyroidism and glaucoma are conflicting. We sought to shed light on this by conducting a critical review and meta-analyses. The meta-analyses were conducted in adherence with the widely accepted MOOSE guidelines. Using the Medical Subject Heading (MeSH) terms: hypothyroidism, myxoedema and glaucoma or intraocular pressure, case-control studies, cohort studies and cross-sectional studies were identified (PubMed) and reviewed. Using meta-analysis, the relative risk (RR) of coexistence of glaucoma and hypothyroidism was calculated...
February 16, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28211175/systematic-review-and-meta-analysis-of-the-association-of-autism-spectrum-disorder-in-visually-or-hearing-impaired-children
#14
Belinda Do, Paige Lynch, Elena-Marie Macris, Brianna Smyth, Stephanie Stavrinakis, Stephen Quinn, Paul A Constable
PURPOSE: To determine whether there is an association with a congenital visual or hearing impairment (VI or HI) and Autism Spectrum Disorder (ASD) in children. METHODS: A systematic literature review was performed using nine relevant databases limited to peer reviewed articles in English between 1994 and January 2016. The search identified 1248 articles after duplicates were removed with subsequent screening of the abstracts excluding a further 1199, resulting in 49 full-text articles that were then independently assessed by five of the authors with a final 15 articles meeting the inclusion criteria...
March 2017: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
https://www.readbyqxmd.com/read/28210547/nipple-areolar-complex-reconstruction-and-patient-satisfaction-a-systematic-review-and-meta-analysis
#15
Ellen S Satteson, Benjamin J Brown, Maurice Y Nahabedian
BACKGROUND: Nipple-areola complex (NAC) reconstruction transforms a mound of soft tissue into a breast and often marks the final stage of breast reconstruction after mastectomy. METHODS: A systematic review and meta-analysis were conducted in accordance with the preferred reporting items for systematic reviews and meta-analysis (PRISMA) guidelines. Articles were classified based on the nipple reconstructive technique-either composite nipple sharing or local flap with nipple-sparing mastectomy (NSM) used as a control...
February 2017: Gland Surgery
https://www.readbyqxmd.com/read/28210482/delayed-interval-delivery-can-save-the-second-twin-evidence-from-a-systematic-review
#16
REVIEW
S Feys, Y Jacquemyn
BACKGROUND: In case of preterm birth in twins, it is not well established if the second twin benefits from a delayed-interval delivery. OBJECTIVE: The main objective of this systematic review is to evaluate survival benefit of the second twin from delayed interval delivery compared to the first twin. Secondly, we will evaluate the survival benefit of the procedure when performed equal to or after 24 weeks gestational age of the first born. METHODS: Delayed interval delivery was defined as every attempt to perform a delayed interval delivery with at minimum placement of a high ligature of the umbilical cord and a delay of delivery of at least 24 hours...
December 2016: Facts, Views & Vision in ObGyn
https://www.readbyqxmd.com/read/28209944/impact-of-contact-force-technology-on-reducing-the-recurrence-and-major-complications-of-atrial-fibrillation-ablation-a-systematic-review-and-meta-analysis
#17
Xianhui Zhou, Wenkui Lv, Wenhui Zhang, Yuanzheng Ye, Yaodong Li, Qina Zhou, Qiang Xing, Jianghua Zhang, Yanmei Lu, Ling Zhang, Hongli Wang, Wen Qin, Baopeng Tang
Contact force (CF) monitoring can be useful in accomplishing circumferential pulmonary vein (PV) isolation for atrial fibrillation (AF). This meta-analysis aimed to assess the efficacy and safety of a CF-sensing catheter in treating AF. Randomized controlled trials or non-randomized observational studies comparing AF ablation using CF-sensing or standard non-CF (NCF)-sensing catheters were identified from PubMed, EMBASE, Cochrane Library, Wanfang Data, and China National Knowledge Infrastructure (January 1, 1998-2016)...
February 2017: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/28209623/access-to-contraception-and-sexual-and-reproductive-health-information-post-abortion-a-systematic-review-of-literature-from-low-and-middle-income-countries
#18
REVIEW
Claire Rogers, Jaya A R Dantas
AIM: This systematic literature review documented, analysed and critiqued the accessibility of contraception and sexual and reproductive health (SRH) information for women living in low- and middle-income countries who have undergone medical or surgical abortion. METHODOLOGY: This review systematically collated relevant and recent empirical evidence regarding women's access to contraception and SRH information post-abortion within low- and middle-income countries...
February 16, 2017: Journal of Family Planning and Reproductive Health Care
https://www.readbyqxmd.com/read/28209592/comparison-of-diagnostic-performance-of-two-question-screen-and-15-depression-screening-instruments-for-older-adults-systematic-review-and-meta-analysis
#19
REVIEW
Kelvin K F Tsoi, Joyce Y C Chan, Hoyee W Hirai, Samuel Y S Wong
BackgroundScreening for depression in older adults is recommended.AimsTo evaluate the diagnostic accuracy of the Two-Question Screen for older adults and compare it with other screening instruments for depression.MethodWe undertook a literature search for studies assessing the diagnostic performance of depression screening instruments in older adults. Combined diagnostic accuracy including sensitivity and specificity were the primary outcomes. Potential risks of bias and the quality of studies were also assessed...
February 16, 2017: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/28209591/psychosocial-therapies-for-the-adjunctive-treatment-of-bipolar-disorder-in-adults-network-meta-analysis
#20
REVIEW
Mary Lou Chatterton, Emily Stockings, Michael Berk, Jan J Barendregt, Rob Carter, Cathrine Mihalopoulos
BackgroundFew trials have compared psychosocial therapies for people with bipolar affective disorder, and conventional meta-analyses provided limited comparisons between therapies.AimsTo combine evidence for the efficacy of psychosocial interventions used as adjunctive treatment of bipolar disorder in adults, using network meta-analysis (NMA).MethodSystematic review identified studies and NMA was used to pool data on relapse to mania or depression, medication adherence, and symptom scales for mania, depression and Global Assessment of Functioning (GAF)...
February 16, 2017: British Journal of Psychiatry: the Journal of Mental Science
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