keyword
MENU ▼
Read by QxMD icon Read
search

b lactamics

keyword
https://www.readbyqxmd.com/read/28078559/empirical-combination-of-a-%C3%AE-lactam-to-vancomycin-may-not-improve-outcomes-of-methicillin-susceptible-staphylococcus-aureus-bacteremia-compared-to-vancomycin-monotherapy
#1
G E Park, J-H Ko, S Y Cho, Y E Ha, N Y Lee, C-I Kang, D R Chung, J-H Song, K R Peck
To evaluate effect of empirical combination of a β-lactam to vancomycin and vancomycin monotherapy in Staphylococcus aureus bacteremia (MSSA-B), we conducted a retrospective cohort study. Electronic medical records of individuals who were diagnosed with MSSA-B between January 2005 and February 2015 at a tertiary care center were reviewed. Patients were classified into three groups according to empirical antibiotic regimen (BL group, β-lactam; VAN group, vancomycin; BV group, combination of β-lactam and vancomycin), and 30-day all-cause mortality of each group was compared...
January 11, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28077672/potentiation-of-ceftazidime-by-avibactam-against-%C3%AE-lactam-resistant-pseudomonas-aeruginosa-in-an-in-vitro-infection-model
#2
Sherwin K B Sy, Luning Zhuang, Marie-Eve Beaudoin, Philipp Kircher, Maria A M Tabosa, Noely C T Cavalcanti, Christian Grunwitz, Sebastian Pieper, Virna J Schuck, Wright W Nichols, Hartmut Derendorf
OBJECTIVES: This study evaluated the in vitro pharmacodynamics of combinations of ceftazidime and the non-β-lactam β-lactamase inhibitor, avibactam, against ceftazidime-, piperacillin/tazobactam- and meropenem-multiresistant Pseudomonas aeruginosa by a quantitative time-kill method. METHODS: MICs of ceftazidime plus 0-16 mg/L avibactam were determined against eight isolates of P. aeruginosa Single-compartment, 24 h time-kill kinetics were investigated for three isolates at 0-16 mg/L avibactam with ceftazidime at 0...
January 10, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28056274/-serotype-identification-and-antibiotic-susceptibility-of-shiga-toxin-producing-escherichia-coli-in-the-weishan-area-in-shandong-province-china
#3
C C Shao, B Hu, Z W Bi, Z Q Kou, M Fang, B L Chen, Z Q Bi
Objective: To determine the serotypes and drug resistance profiles of Shiga toxin-producing Escherichia coli (STEC) in animal stools from the Weishan area in Shandong Province, China. To provide the basis for further study. Methods: Five hundred animal stool samples (from pigs, cattle, sheep, dogs and birds) were collected from the Weishan area and STEC strains were isolated from these samples. Strains were serotyped by a serum agglutination test, and their drug resistance profiles were determined through antimicrobial sensitivity experiments...
January 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28052449/new-iminophosphorane-au-i-complexes-as-efficient-catalysts-for-the-cycloisomerization-of-alkynyl-amides-under-air-room-temperature-and-in-aqueous-or-eutectic-mixture-solutions
#4
Joaquin García-Álvarez, María Jesús Rodríguez-Álvarez, Cristian Vidal, Javier Borge, Sören Schumacher
New iminophosphorane-phosphine Au(I) complexes [AuCl(κ1-P-Ph2PCH2P{=NP(=S)(OR)2}Ph2)] (3a-b) and [Au2Cl2(μ2-P,S-Ph2PCH2P{=NP(=S)(OR)2}Ph2)] (4a-b) probed to be general, very efficient and recyclable (up to four consecutive runs) catalysts for the cycloisomerization of alkynyl amides using water or choline chloride-based eutectic mixtures as green solvents. Remarkably, this cycloisomerization reaction took place under mild conditions (small catalyst loading, at room temperature and in the absence of co-catalysts or protecting atmosphere) giving rise to the corresponding alkylidene lactams by employing an efficient and sustainable methodology...
January 3, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28040165/antimicrobial-susceptibility-and-genetic-characterization-of-escherichia-coli-recovered-from-frozen-game-meat
#5
Rafael H Mateus-Vargas, Viktoria Atanassova, Felix Reich, Günter Klein
The increasing number of antimicrobial resistant Enterobacteriaceae both in veterinary and human medicine, the dissemination of these bacteria in several environments and their possible repercussions on human health is causing concern. Game meat is usually seen as free of antimicrobial resistant bacteria. The objective of this study was to evaluate the current antimicrobial susceptibility status in generic Escherichia coli isolated from packed frozen game meat from a game handling establishment in Germany. A total of 229 E...
May 2017: Food Microbiology
https://www.readbyqxmd.com/read/28017793/narrow-spectrum-%C3%A3-lactam-monotherapy-in-hospital-treatment-of-community-acquired-pneumonia-a-register-based-cohort-study
#6
Samuel Rhedin, Ilias Galanis, Fredrik Granath, Anders Ternhag, Jonas Hedlund, Carl Spindler, Pontus Naucler
OBJECTIVES: To assess the clinical effect of empirical treatment with narrow-spectrum ß-lactam monotherapy (NSBM) versus broad-spectrum ß-lactam monotherapy (BSBM) in non-severe community-acquired pneumonia (CAP). METHODS: Hospitalised patients ≥18 years with CAP that received initial NSBM or BSBM, with a severity score according to CRB-65≤2 (C=confusion, R=respiratory rate >30/min, B=systolic blood pressure <90 mmHg or diastolic blood pressure ≤60 mmHg, 65= ≥65 years), in the Swedish Pneumonia Register from 2008-11 were included...
December 22, 2016: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/27980845/crystal-structures-of-three-bicyclic-carbohydrate-derivatives
#7
Uwe Schilde, Alexandra Kelling, Sumaira Umbreen, Torsten Linker
The title compounds, [(1R,3R,4R,5R,6S)-4,5-bis-(acet-yloxy)-7-oxo-2-oxabi-cyclo[4.2.0]octan-3-yl]methyl acetate, C14H18O8, (I), [(1S,4R,5S,6R)-5-acet-yloxy-7-hy-droxy-imino-2-oxobi-cyclo-[4.2.0]octan-4-yl acetate, C11H15NO6, (II), and [(3aR,5R,6R,7R,7aS)-6,7-bis-(acet-yloxy)-2-oxo-octa-hydro-pyrano[3,2-b]pyrrol-5-yl]methyl acetate, C14H19NO8, (III), are stable bicyclic carbohydrate derivatives. They can easily be synthesized in a few steps from commercially available glycals. As a result of the ring strain from the four-membered rings in (I) and (II), the conformations of the carbohydrates deviate strongly from the ideal chair form...
December 1, 2016: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/27956267/intravenous-fosfomycin-back-to-the-future-systematic-review-and-meta-analysis-of-the-clinical-literature
#8
REVIEW
B Grabein, W Graninger, J Rodríguez Baño, A Dinh, D B Liesenfeld
OBJECTIVES: We conducted a systematic review and meta-analysis to summarise the clinical evidence and usage patterns of intravenous fosfomycin from its development to the present time. METHODS: PubMed, the Cochrane Library and local journals were searched for relevant studies reporting aggregated data of intravenous fosfomycin use in adults and children, with no restrictions regarding study design. Single case reports were excluded. Data were systematically abstracted for all included studies...
December 9, 2016: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/27935180/management-of-early-onset-neonatal-sepsis-differs-in-the-north-and-south-of-scandinavia
#9
Martin Drageset, Jon Widding Fjalstad, Sven Mortensen, Claus Klingenberg
AIM: This study compared the management and outcomes of early-onset neonatal sepsis (EONS) in two tertiary neonatal units in Denmark and Norway. METHODS: We retrospectively studied all infants diagnosed with EONS between April 2010 and March 2013 and managed at Odense University Hospital, Denmark, and the University Hospital of North Norway, Norway. Clinical and laboratory data were collected from patient records. RESULTS: We identified 137 EONS cases in Denmark and 101 in Norway...
December 9, 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27934490/mechanism-and-stereoselectivity-in-an-asymmetric-n-heterocyclic-carbene-catalyzed-carbon-carbon-bond-activation-reaction
#10
Monika Pareek, Raghavan B Sunoj
The mechanism and origin of stereoinduction in a chiral N-heterocyclic carbene (NHC) catalyzed C-C bond activation of cyclobutenone has been established using B3LYP-D3 density functional theory computations. The activation of cyclobutenone as an NHC-bound vinyl enolate and subsequent reaction with the electrophilic sulfonyl imine leads to the lactam product. The most preferred stereocontrolling transition state exhibits a number of noncovalent interactions rendering additional stabilization. The computed enantio- and diastereoselectivities are in good agreement with the previous experimental observations...
November 18, 2016: Organic Letters
https://www.readbyqxmd.com/read/27934260/long-term-impact-of-field-applications-of-sewage-sludge-on-soil-antibiotic-resistome
#11
Wan-Ying Xie, Steve P McGrath, Jian-Qiang Su, Penny R Hirsch, Ian M Clark, Qirong Shen, Yong-Guan Zhu, Fang-Jie Zhao
Land applications of municipal sewage sludge may pose a risk of introducing antibiotic resistance genes (ARGs) from urban environments into agricultural systems. However, how the sewage sludge recycling and application method influence soil resistome and mobile genetic elements (MGEs) remains unclear. In the present study, high through-put quantitative PCR was conducted on the resistome of soils from a field experiment with past (between 1994 and 1997) and annual (since 1994) applications of five different sewage sludges...
December 6, 2016: Environmental Science & Technology
https://www.readbyqxmd.com/read/27934011/a-mechanistic-model-for-colibactin-induced-genotoxicity
#12
Alan R Healy, Herman Nikolayevskiy, Jaymin R Patel, Jason M Crawford, Seth B Herzon
Precolibactins and colibactins represent a family of natural products that are encoded by the clb gene cluster and are produced by certain commensal, extraintestinal, and probiotic E. coli. clb(+) E. coli induce megalocytosis and DNA double-strand breaks in eukaryotic cells, but paradoxically, this gene cluster is found in the probiotic Nissle 1917. Evidence suggests precolibactins are converted to genotoxic colibactins by colibactin peptidase (ClbP)-mediated cleavage of an N-acyl-d-Asn side chain, and all isolation efforts have employed ΔclbP strains to facilitate accumulation of precolibactins...
December 7, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27927163/phenotypic-and-molecular-detection-of-the-bla-kpc-gene-in-clinical-isolates-from-inpatients-at-hospitals-in-s%C3%A3-o-luis-ma-brazil
#13
Patricia Cristina Saldanha Ribeiro, Andrea Souza Monteiro, Sirlei Garcia Marques, Sílvio Gomes Monteiro, Valério Monteiro-Neto, Martina Márcia Melo Coqueiro, Ana Cláudia Garcia Marques, Rosimary de Jesus Gomes Turri, Simone Gonçalves Santos, Maria Rosa Quaresma Bomfim
BACKGROUND: Bacteria that produce Klebsiella pneumoniae carbapenemases (KPCs) are resistant to broad-spectrum β-lactam antibiotics. The objective of this study was to phenotypically and genotypically characterize the antibiotic susceptibility to carbapenems of 297 isolates recovered from clinical samples obtained from inpatients at 16 hospitals in São Luis (Maranhão, Brazil). METHODS: The study was conducted using phenotypic tests and molecular methods, including polymerase chain reaction (PCR), sequencing and enterobacterial repetitive intergenic consensus (ERIC)-PCR...
December 7, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27920760/prevalence-of-the-antibiotic-resistance-genes-in-coagulase-positive-and-negative-staphylococcus-in-chicken-meat-retailed-to-consumers
#14
Kamelia Osman, Jihan Badr, Khalid S Al-Maary, Ihab M I Moussa, Ashgan M Hessain, Zeinab M S Amin Girah, Usama H Abo-Shama, Ahmed Orabi, Aalaa Saad
The use of antibiotics in farm management (growing crops and raising animals) has become a major area of concern. Its implications is the consequent emergence of antibiotic resistant bacteria (ARB) and accordingly their access into the human food chain with passage of antibiotic resistance genes (ARG) to the normal human intestinal microbiota and hence to other pathogenic bacteria causative human disease. Therefore, we pursued in this study to unravel the frequency and the quinolone resistance determining region, mecA and cfr genes of methicillin-susceptible Staphylococcus aureus (MSSA), methicillin-resistant S...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27919894/carbapenemase-producing-enterobacteriaceae-recovered-from-the-environment-of-a-swine-farrow-to-finish-operation-in-the-united-states
#15
Dixie F Mollenkopf, Jason W Stull, Dimitria A Mathys, Andrew S Bowman, Sydnee M Feicht, Susan V Grooters, Joshua B Daniels, Thomas E Wittum
Carbapenem-resistant Enterobacteriaceae (CRE) present an urgent threat to public health. While carbapenem antimicrobials are restricted in food-producing animals, other β-lactams, such as ceftiofur, are used in livestock. This use may provide selection pressure favoring the amplification of carbapenem resistance but this relationship has not been established. Previously unreported from US livestock, plasmid-mediated CREs have been reported from livestock in Europe and Asia.Environmental and fecal samples were collected from a 1,500 sow, US farrow-to-finish operation during 4 visits over a 5 month period, 2015...
December 5, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27902368/coagulase-negative-staphylococci-pathogenesis-occurrence-of-antibiotic-resistance-genes-and-in-vitro-effects-of-antimicrobial-agents-on-biofilm-growing-bacteria
#16
Ewa Szczuka, Lucyna Jabłońska, Adam Kaznowski
Coagulase-negative staphylococci (CoNS) are opportunistic pathogens that particularly cause infections in patients with implanted medical devices. The present research was performed to study the virulence potential of 53 clinical isolates of Staphylococcus capitis, Staphylococcus auricularis, Staphylococcus lugdunensis, Staphylococcus simulans, Staphylococcus cohnii and Staphylococcus caprae. All clinical strains were clonally unrelated. Isolates carried genes encoding resistance to β-lactam (mecA) (15 %), aminoglycoside [aac(6')/aph(2″)(11 %), aph (3')-IIIa (15 %), ant(4')-Ia (19 %)] and macrolide, lincosamide and streptogramin B (MLSB) [erm(A) (4 %), erm(B) (13 %), erm(C) (41 %), msr(A) (11 %)] antibiotics...
December 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27889169/characterization-of-biocide-tolerant-bacteria-isolated-from-cheese-and-dairy-small-medium-enterprises
#17
Ma Luisa Fernández Márquez, Ma José Grande Burgos, Ma Carmen López Aguayo, Rubén Pérez Pulido, Antonio Gálvez, Rosario Lucas
A collection of 120 bacterial isolates from small medium enterprises involved in the production of cow milk and the manufacture of goat cheese were screened for sensitivity to biocides benzalkonium chloride (BC), cetrimide (CT), hexadecylpyridinium chloride (HDP), triclosan (TC), hexachlorophene (CF) and poly-(hexamethylen guanidinium) hydrochloride (PHMG). Nineteen isolates were selected according to biocide tolerance and identified by 16S rDNA sequencing as Lactococcus sp. (6) Enterococcus sp. (1), Lactobacillus sp...
April 2017: Food Microbiology
https://www.readbyqxmd.com/read/27867083/trends-in-antimicrobial-resistance-among-bacteroides-species-and-parabacteroides-species-in-the-united-states-from-2010-2012-with-comparison-to-2008-2009
#18
REVIEW
D R Snydman, N V Jacobus, L A McDermott, E J C Goldstein, L Harrell, S G Jenkins, D Newton, R Patel, D W Hecht
The susceptibility trends for Bacteroides fragilis and related species against various antibiotics were determined using data from 3 years of surveillance (2010-2012) on 779 isolates referred by 7 medical centers. The antibiotic test panel included imipenem, ertapenem, meropenem, ampicillin-sulbactam, piperacillin-tazobactam, cefoxitin, clindamycin, moxifloxacin, tigecycline, linezolid, chloramphenicol and . MICs were determined using the agar dilution CLSI reference method. Carbapenem resistance remained low (range 1...
November 17, 2016: Anaerobe
https://www.readbyqxmd.com/read/27861994/detection-of-drug-responsive-b-lymphocytes-and-antidrug-igg-in-patients-with-%C3%AE-lactam-hypersensitivity
#19
M O Amali, A Sullivan, R E Jenkins, J Farrell, X Meng, L Faulkner, P Whitaker, D Peckham, B K Park, D J Naisbitt
BACKGROUND: Delayed-type β-lactam hypersensitivity develops in subset of patients. The cellular immunological processes that underlie the drug-specific response have been described; however, little is known about involvement of the humoral immune system. Thus, the aim of this study was to utilize piperacillin hypersensitivity as an exemplar to (i) develop cell culture methods for the detection of drug-specific B-cell responses, (ii) characterize drug-specific IgG subtypes and (iii) assess reactivity of IgG antibodies against proteins modified to different levels with piperacillin haptens...
November 15, 2016: Allergy
https://www.readbyqxmd.com/read/27847122/electrochemical-mineralization-of-cephalexin-using-a-conductive-diamond-anode-a-mechanistic-and-toxicity-investigation
#20
Douglas A C Coledam, Marília M S Pupo, Bianca F Silva, Adilson J Silva, Katlin I B Eguiluz, Giancarlo R Salazar-Banda, José M Aquino
The contamination of surface and ground water by antibiotics is of significant importance due to their potential chronic toxic effects to the aquatic and human lives. Thus, in this work, the electrochemical oxidation of cephalexin (CEX) was carried out in a one compartment filter-press flow cell using a boron-doped diamond (BDD) electrode as anode. During the electrolysis, the investigated variables were: supporting electrolyte (Na2SO4, NaCl, NaNO3, and Na2CO3) at constant ionic strength (0.1 M), pH (3, 7, 10, and without control), and current density (5, 10 and 20 mA cm(-2))...
February 2017: Chemosphere
keyword
keyword
108532
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"