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female genital

Xi Lu, Chunmeng Li, Wangping Li, Xiaoheng Long, Yanfeng Fang, Ruilin Sun, Faguang Jin, Enqing Fu, Yonghong Xie
BACKGROUND: Female genital tuberculosis (FGTB) is one of the major causes of infertility. However, nonspecific manifestations and the lack of easy access to gold-standard diagnostic test render a diagnostic difficult for FGTB. The objective of this study was to determine T-SPOT.TB (an interferon-γ release assay, IGRA) performance in patients with FGTB. METHODS: A total of 213 female patients with validated T-SPOT.TB results were recruited in this retrospective study...
July 13, 2018: Journal of Clinical Laboratory Analysis
Farhad Shahram, Abdolhadi Nadji, Massoomeh Akhlaghi, Seyyedeh Tahereh Faezi, Cheyda Chams-Davatchi, Hormoz Shams, S Zahra Ghodsi, Fereydoun Davatchi
OBJECTIVES: This study proposed to report the characteristics of paediatric Behçet's disease (PED-BD) in a cohort of patients from Iran's registry and compare them with different reports throughout the world. METHODS: From a cohort of 7504 Iranian patients with Behçet's disease those diagnosed before the age of 16 years were included in this study. Data were collected on a standard protocol comprising 105 items, including demographic features, type of presentation, and different clinical and laboratory findings...
June 19, 2018: Clinical and Experimental Rheumatology
Ercan Yilmaz, Mehmet Gul, Rauf Melekoglu, Ebru Inci Coskun, Nurhan Sahin, Semir Gul, Ayse Gulcin Bastemur, Baris Ciplak
Objectives Endometrial cancer is the most frequent tumor of the female genital tract. Ubiquitin is a small protein (8.5 kDa) found in all eukaryotic cells, binds to substrate proteins via a three-phase enzymatic pathway referred to as ubiquitination and plays an important role in cellular stability. Neural precursor cell-expressed developmentally down-regulated 4-like (NEDD4L) functions in the last phase of this enzymatic process. In this study, we investigated NEDD4L protein expression in endometrial cancer...
January 1, 2018: Journal of International Medical Research
Jordan Ari Schwartz, Hongliang Zhang, Zachary Ende, Martin J Deymier, Terry Lee, Joel Singer, Tony Mazzulli, Eric Hunter, Mario A Ostrowski
HIV-1 infection often arises from a single transmitted/founder (TF) viral variant, amongst a large pool of viruses in the quasispecies in the transmitting partner. TF variants are typically non-dominant in blood and genital secretions, indicating unique traits. The plasmacytoid dendritic cell (pDC) is the primary IFN-α producing cell in response to viral infections, and is rapidly recruited to the female genital tract upon exposure to HIV-1. The impact of the pDC on transmission is unknown. We investigated whether evasion of pDC responses was a trait of TF viruses...
July 11, 2018: Journal of Virology
Oscar J Manrique, Kian Adabi, Andres A Maldonado, Tony C Huang, Jorys Martinez-Jorge, Pierre Brassard, Ricardo Galan, Pedro Ciudad, Mohamed Diya Sabbagh
PURPOSE: The lack of erogenous sensitivity in the neovagina is one of the major shortcomings for patients undergoing male-to-female genital confirmation surgery. Remnant fibers of the dorsal nerve of the penis (DNP) after clitroplasty can potentially be used for a second neurovascular pedicle flap for intravaginal erogenous sensation. METHODS: An anatomic dissection of the DNP was performed in 10 male frozen pelvises to identify major trunks and their branches. Lateral branches of DNP were preserved for a sensate "O" pedicle flap for the vagina...
July 10, 2018: Annals of Plastic Surgery
Pedro Vieira-Baptista, Gutemberg Almeida, Fabrizio Bogliatto, Tanja Gizela Bohl, Matthé Burger, Bina Cohen-Sacher, Karen Gibbon, Andrew Goldstein, Debra Heller, Wendy Likes, Celene Longo da Silva, Claudia Marchitelli, Micheline Moyal-Barracco, Kathleen Posey, Maria Celeste Sluga, Colleen Kennedy Stockdale, Gisele Vissoci Marquini, Kamil Zalewski
Female genital cosmetic surgeries (FGCSs) and procedures are increasingly being advertised as common, simple, and complication-free, capable of not only improving aesthetic appearance but also increasing self-esteem and sexual pleasure.Guidelines for physicians and clear, scientifically correct information for patients must be made available, to minimize the number of ineffective or deleterious procedures.The International Society for the Study of Vulvovaginal Disease positions/recommendations regarding FGCS are as follows:1...
July 9, 2018: Journal of Lower Genital Tract Disease
K Katharina Rall, Birgitt Schoenfisch, Dorit Schoeller, Diana Stefanescu, Andrina Koelle, Melanie Henes, Markus Huebner, Florin Andrei Taran, Harald Seeger, Angelika Iftner, Thomas Iftner, Sara Yvonne Brucker
OBJECTIVE: To study vaginal as opposed to cervical HPV acquisition with regard to true prevalence, HPV types, and the role of co-factors in virgins and after their sexual debut. DESIGN: Prospective epidemiological observational study. SETTING: University hospital specialized in genital malformations. POPULATION: Women diagnosed with MRKHS and undergoing neovaginoplasty between November 2011 and July 2017. METHODS: This is a prospective study including 186 MRKH patients before and after sexual debut...
July 10, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
A F Silva, P J A Farias, M L C R Silva, J P Araújo Júnior, C D Malossi, L S Ullmann, D F Costa, S S S Higino, S S Azevedo, C J Alves
Although some studies in sheep have indicated leptospire colonization of the genital tract, further studies are needed to clarify the role of genital carriers in this species. Thus, this study aimed to evaluate the colonization of pathogenic leptospires in the genital and urinary tract of slaughtered sheep. Fifty-seven adult, female woolless sheep destined for slaughter were used. Renal (n = 57), bladder (n = 57), ovary (n = 34), uterine tube (n = 44), and uterus (n = 33) samples were collected for molecular detection of Leptospira sp...
July 9, 2018: Tropical Animal Health and Production
Elisabeth McClymont, Marette Lee, Janet Raboud, François Coutlée, Sharon Walmsley, Nancy Lipsky, Mona Loutfy, Sylvie Trottier, Fiona Smaill, Marina B Klein, Marianne Harris, Jeffrey Cohen, Mark H Yudin, Wendy Wobeser, Deborah Money
Background: Human papillomavirus (HPV) vaccination is safe and efficacious in women without HIV. While good immunogenicity has been observed in women living with HIV (WLWH), efficacy data in this population are needed. Methods: We enrolled 420 females aged ≥9 years (range: 9-65) living with HIV. Participants were to receive 3 doses of qHPV vaccine (0/2/6 months). The main endpoint was vaccine failure (i.e., incident persistent qHPV infection, cervical intraepithelial neoplasia of grade 2 or higher (CIN2+), or genital warts)...
July 7, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
P de Graaf, R Ramadan, E C Linssen, N A Staller, A P A Hendrickx, G L S Pigot, E J H Meuleman, M Bouman, M Özer, J L H R Bosch, L M O de Kort
PURPOSE: Urethral reconstruction is performed in patients with urethral strictures or for correction of congenital disorders. In the case of shortage of tissue, engineered tissue may enhance urethral reconstruction. As the corpus spongiosum (CS) is important in supporting the function of the urethra, tissue engineering of the urethra should be combined with reconstruction of a CS. For that purpose, detailed knowledge of the composition of the CS, more specifically its extracellular matrix (ECM) and vascularization is needed for scaffold design...
July 9, 2018: Histology and Histopathology
Yoshimi Ishii, Shin Fujisawa, Taiki Ando, Taisei Suzuki, Yasufumi Ishiyama, Kumiko Kishimoto, Yukako Hattori, Yuki Nakajima, Takuya Miyazaki, Hirotaka Takasaki, Kenji Matsumoto, Hideyuki Koharazawa, Jun Taguchi, Katsumichi Fujimaki, Rika Sakai, Hideaki Nakajima
AIM: Primary malignant lymphomas arising from the female genital tract are very rare, with an incidence rate of 0.5%. Because of its rarity, its clinical characteristics, prognosis and optimal treatment are still unclear. Here, we retrospectively evaluated female patients with uterine lymphoma. METHODS: Between January 2000 and October 2016, 4362 patients were newly diagnosed with malignant lymphoma by the participating institutions of YACHT. Among these 4362 patients, we retrospectively evaluated 14 adult patients with primary uterine lymphoma...
July 8, 2018: Asia-Pacific Journal of Clinical Oncology
Maurizio Serati, Stefano Salvatore, Diaa Rizk
No abstract text is available yet for this article.
July 7, 2018: International Urogynecology Journal
Elke Smith, Jessica Junger, Katharina Pauly, Thilo Kellermann, Joseph Neulen, Christiane Neuschaefer-Rube, Birgit Derntl, Ute Habel
The phenomenon of gender incongruence is hypothesized to arise from a discrepant sexual development of the brain and the genitals, contingent on genetic and hormonal mechanisms. We aimed at visualizing transgender identity on a neurobiological level, assuming a higher functional similarity to individuals of the aspired rather than assigned sex. Implementing a gender perception paradigm featuring male and female voice stimuli, behavioral and functional imaging data of transmen were compared to men and women, and to transwomen, respectively...
July 5, 2018: Hormones and Behavior
J-B Schaff, E Fontaine, C Dariane, A Mejean, L Lantieri, M Hivelin
Classical bladder exstrophy (CBE), affecting 1 birth out of 30,000, is characterized by an evaginated bladder plate through a defect in the lower abdominal wall, multiple abdominal wall anomalies including a pubic bone arch dehiscence. Numerous approaches from childhood to adulthood are thus required, depending on the severity of the deformity, including the associated genital anomalies. We report the case of a 19-year-old woman with CBE with a history of three-failed primary closure. We performed a secondary neck closure with a concomitant suspension of the bladder neck and reconstruction of the lower abdominal wall using a bilateral gracilis muscle flap transposition...
July 3, 2018: Annales de Chirurgie Plastique et Esthétique
Janine Medeiros da Silva, Emily Ramos Calife, João Victor de Sousa Cabral, Hildemárzio Pinheiro Falcão de Andrade, Ana Katherine Gonçalves
Hemangioma is a benign neoplasm that may affect the vulva, and it can cause functional or emotional disability. This article reports the case of a 52-year-old female patient with a history of a genital ulcer for the past 3 years and who had undergone various treatments with creams and ointments. The patient was biopsied and diagnosed with vulvar hemangioma and was subsequently submitted to surgical excision of the lesion. We emphasize the importance of following the steps of the differential diagnosis and proceeding with a surgical approach only if necessary...
June 2018: Revista Brasileira de Ginecologia e Obstetrícia
Sophie Duchesne, Marie Seyller, Patrick Chariot
BACKGROUND: Male sexual assaults were long ignored, possibly because of the myth acceptance that a man can only be the perpetrator of sexual assaults. It is increasingly admitted that all males can be victims of rape. We described the characteristics of a series of male adolescent and adult victims of sexual assault who had a forensic medical examination. METHODS: We conducted an observational study over 8 years. RESULTS: We included 98 male patients aged 15 years and older (range 15-66, median 25) at the time of a reported sexual assault...
June 23, 2018: Forensic Science International
Shiro Takamatsu, Kosuke Murakami, Hisamitsu Takaya, Takako Tobiume, Hidekatsu Nakai, Ayako Suzuki, Masaki Mandai, Noriomi Matsumura
Malignant psoas syndrome (MPS) is a rare and unique cancer-associated syndrome caused by the malignant involvement of the psoas major muscle, and is characterized by ipsilateral lumbosacral plexopathy and painful hip flexion. The pain in MPS is often distressing and intractable, and there is no established effective treatment approach. Herein, the present study reports on three cases of MPS associated with gynecological malignancies, wherein symptom improvement was observed following chemotherapy or radiotherapy...
July 2018: Molecular and Clinical Oncology
Sileshi Abdissa, Tamrat Abebe, Gobena Ameni, Sisay Teklu, Yonas Bekuretsion, Markos Abebe, Adane Mihret
BACKGROUND: Female genital tuberculosis (FGTB) is known to cause severe tubal disease leading to infertility and its incidence closely parallels with the overall prevalence of tuberculosis (TB) in a community. Its magnitude is underreported because diagnosis is difficult and requires invasive techniques. In this study we determined the prevalence of endometrial tuberculosis and characterized isolates among women who underwent endometrial biopsy for evaluation of various conditions at a Tikur Anbessa Specialized Hospital (TAHS), Addis Ababa, Ethiopia...
July 5, 2018: BMC Infectious Diseases
Jackson A Tomlinson, Ivan G Horak, Dmitry A Apanaskevich
Haemaphysalis (Rhipistoma) muhsamae Santos Dias, 1954 (Acari: Ixodidae) and H. (R.) subterra Hoogstraal, El Kammah & Camicas, 1992, are redescribed based on males and females. Adults of H. muhsamae were mostly collected from various mongooses (Carnivora: Herpestidae) but also from the striped polecat, Ictonyx striatus (Perry) (Carnivora: Mustelidae), serval, Leptailurus serval (Schreber) (Carnivora: Felidae), red veld rat, Aethomys chrysophilus (de Winton) and Selinda veld rat, Aethomys silindensis Roberts (Rodentia: Muridae) in Botswana, Kenya, Mozambique, South Africa, Tanzania and Zimbabwe...
July 4, 2018: Systematic Parasitology
Dejan Nikolić, Miroslav Granić, Nebojša Ivanović, Darko Zdravković, Aleksandra Nikolić, Violeta Stanimirović, Marija Zdravković, Srdjan Dikić, Marko Nikolić, Miroslav Djordjević
INTRODUCTION: Lesbian, gay, and bisexuals have unique healthcare needs. Breast cancer is leading cancer in women, worldwide, accounting for 25% of all cases. Annual incidence rates increased significantly in all countries and age groups. The occurrence of breast cancer is rare in transgender population. As they have very limited access to medical care, it is much less likely to pursue breast cancer screening than in other individuals not identified as transgender. REVIEW OF THE CASES FROM LITERATURE: Up to date, only 13 cases of the breast cancer transsexuals (female to male) have been reported in six published papers worldwide...
July 5, 2018: Breast Cancer Research and Treatment
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