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Retinal occlusion

Wilai Thanasarnaksorn, Sebastian Cotofana, Christina Rudolph, Patcharahatai Kraisak, Nongsak Chanasumon, Atchima Suwanchinda
Hyaluronic acid (HA) injection is a popular nonsurgical, facial rejuvenating procedure. Due to the rapidly expanding use of HA injections, significant potential complications have also increased in frequency. Among these complications, the rare but most devastating one is arterial occlusion, which can result in skin necrosis or blindness. To describe the mechanisms behind vision loss secondary to hyaluronic acid injection and the efficacy of treatments to restore vision and associated ocular functionality. We reviewed six cases of patients from October 2011 to December 2017 who experienced vision loss after receiving facial HA injections and the subsequent treatments undertaken to attempt to reverse the vision loss and additional eye complications...
July 13, 2018: Journal of Cosmetic Dermatology
Frederick T Fraunfelder, Frederick W Fraunfelder
PURPOSE: To evaluate possible associations between oral anti-vascular endothelial growth factor (VEGF) drugs and ocular side effects. METHODS: Spontaneous reports were collected and evaluated by the National Registry of Drug-Induced Ocular Side Effects on the three oral anti-VEGF drugs (pazopanib, sorafenib, and sunitinib) for possible ocular side effects. RESULTS: Reported side effects include blurred or decreased vision (389 cases); periocular or eyelid edema (273 cases); superficial anterior segment toxicity (270 cases); conjunctival, retinal, or vitreous bleeding (77 cases); retinal detachments (RDs) or retinal tears (RTs) (75 cases); extraocular muscle disorders, including ptosis (51 cases); discoloration of eyelashes (36 cases); retinal arterial or venous occlusions (26 cases); optic nerve disorders, including papilledema and ischemic optic neuropathy (21 cases); uveitis (10 cases); and macular edema (7 cases)...
July 13, 2018: Journal of Ocular Pharmacology and Therapeutics
Alessandro Arrigo, Adriano Carnevali, Riccardo Sacconi, Lea Querques, Giuseppe Querques, Francesco Bandello
Purpose: To report a case of a patient affected by branch retinal vein occlusion (BRVO) showing a possible spontaneous retinal-choroidal anastomosis (RCA) at the level of the fovea. Observations: A 72 years old male patient with diagnosis of BRVO of left eye (LE) one year before came to our observation for a follow-up visit.The patient underwent a complete ophthalmologic examination, including fluorescein angiography, structural optical coherence tomography (OCT), OCT-Angiography (OCT-A)...
September 2018: American Journal of Ophthalmology Case Reports
Annie M Wu, Connie M Wu, Paul B Greenberg, Fei Yu, Flora Lum, Anne L Coleman
Purpose: To describe the frequency and variation of intravitreal bevacizumab and ranibizumab use for branch retinal vein occlusion (BVO) in the United States (US). Methods: We obtained a 5% random sample of Medicare beneficiaries from the Medicare Denominator and Physician/Supplier Part B claims files from 2010 to 2013 and identified all beneficiaries with an ICD-9-CM code for branch retinal vein occlusion (BVO, 362.36). Patient age, gender, race, state of residence and Charlson Comorbidity Index (CCI) scores were collected...
September 2018: American Journal of Ophthalmology Case Reports
Raval Vishal, Oli Avadesh, Rao Srinivas, Das Taraprasad
Purpose: To describe a rare case of retinal racemose hemangioma (RRH) with retinal artery macroaneurysm (RAM) and its optical coherence tomography angiography (OCT-A) finding before and after treatment. Observations: Congenital arteriovenous (AV) communications or RRH is a rare developmental anomaly associated with various ocular conditions. RRH alone is usually asymptomatic, and vision loss occurs when associated with other ocular complications like retinal vein occlusion, hemmorage, macular edema and macroaneurysm...
September 2018: American Journal of Ophthalmology Case Reports
Tuna Çelik, Feyza Bilen, Fatime Nilüfer Yalçındağ, Huban Atilla
Optical coherence tomography angiography (OCTA) is a non-invasive alternative method used in the diagnosis and follow-up of acute branch retinal artery occlusion to show changes secondary to ischemia. We report a case with acute branch retinal artery occlusion. A 52-year-old man presented with a complaint of sudden-onset visual loss in the right lower quadrant of the left eye for the previous three days. Best-corrected visual acuity was 0.4 temporally. Inferonasal visual field deficit was detected with confrontation...
June 2018: Turkish Journal of Ophthalmology
Rupesh Agrawal, Bryan Ang, Praveen Kumar Balne, Christopher Richards, Thomas Smart, João Cardoso, David Shima, Philip H Jones, Carlos Pavesio
PURPOSE: To investigate differences in red blood cell (RBC) deformability between birdshot chorioretinopathy (BCR) subjects and matched controls, and to postulate its relationship with lack of vascular occlusion in BCR. METHODS: In a single center, prospective, non-randomized mechanistic study, blood samples were collected from eight healthy controls and nine BCR patients, and subjected to biochemical and hematological tests, as well as RBC indices assessment using dual-beam optical tweezers...
July 9, 2018: Ocular Immunology and Inflammation
Ichiro Kawashima, Katsuhiro Takano, Takuma Kumagai, Megumi Koshiishi, Saori Oishi, Yuki Sueki, Kei Nakajima, Toru Mitsumori, Keita Kirito
Coagulation abnormalities are a rare but critical complication associated with plasma cell diseases. We herein present a case of multiple myeloma (MM) with complicated coagulopathy. Initially, the patient showed severe bleeding tendency due to concomitant acquired hemophilia A and acquired von Willebrand syndrome. Interestingly, the patient also exhibited hyperactivation of factor IX. During treatment for MM, the bleeding complications were ameliorated; however, the patient had central retinal vein occlusion...
July 6, 2018: Internal Medicine
Yoshifumi Hida, Shinsuke Nakamura, Anri Nishinaka, Yuki Inoue, Masamitsu Shimazawa, Hideaki Hara
Rho-associated coiled-coil containing protein kinase (ROCK) inhibitors are used to treat glaucoma patients and have protective effects on ischemic states. However, it is poorly understood how the ROCK pathway affects the pathological signs of retinal vein occlusion (RVO). In this study, we evaluated the effects of ripasudil, a ROCK inhibitor, on a murine RVO model. In vivo, RVO was induced by retinal vein laser irradiation in mice, and evaluated with ripasudil. In vitro, the effects of ripasudil were examined on tight junction protein integrity in human retinal microvascular endothelial cells (HRMECs)...
June 19, 2018: Journal of Pharmacological Sciences
M Aymonier, A Mazzioto, L Gaigne, L Swiader, J-M Durand
INTRODUCTION: Retinal vein occlusion presents as an acute, painless and unilateral sight loss. We report two cases of retinal vein occlusion (CRVO) in which the etiology was unusual. CASE REPORTS: Case 1. A 54-year-old woman without any significant past medical history presented with an acute loss of vision. Medical history taking revealed the practice of yoga with headstand posture like "Sirsana". Case 2. A 35-year-old woman presented with an acute loss of vision related to a retinal vein occlusion...
July 5, 2018: La Revue de Médecine Interne
J L Lauermann, A K Woetzel, M Treder, M Alnawaiseh, C R Clemens, N Eter, Florian Alten
PURPOSE: To assess the prevalences of segmentation errors and motion artifacts in optical coherence tomography angiography (OCT-A) in different retinal diseases METHODS: In a retrospective analysis, multimodal retinal imaging including OCT-A was performed in one eye of 57 healthy controls (50.96 ± 22.4 years) and 149 patients (66.42 ± 14.1 years) affected by different chorioretinal diseases: early/intermediate age-related macular degeneration (AMD; n = 26), neovascular AMD (nAMD; n = 22), geographic atrophy due to AMD (GA; n = 6), glaucoma (n = 28), central serous chorioretinopathy (CSC; n = 14), epiretinal membrane (EM; n = 26), retinal vein occlusion (RVO; n = 11), and retinitis pigmentosa (RP; n = 16)...
July 7, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Durga S Borkar, Anthony Obeid, Daniel C Su, Philip P Storey, Xinxiao Gao, Carl D Regillo, Richard S Kaiser, Sunir J Garg, Jason Hsu
PURPOSE: To evaluate practice patterns for bilateral same day intravitreal anti- vascular endothelial growth factor (VEGF) injections and determine the rate of unilateral and bilateral post-injection endophthalmitis after bilateral same day intravitreal anti-VEGF injections. DESIGN: Retrospective cohort study METHODS: The records of a large academic private practice were electronically queried for all office visits during which bilateral intravitreal anti-VEGF injections were performed between April 1, 2012 and August 21, 2017 for patients with a diagnosis of neovascular age-related macular degeneration, diabetic macular edema, or retinal vein occlusion...
July 5, 2018: American Journal of Ophthalmology
Makinderjit Dulai, Mohamed Elsherif, Wael Tawfick, Edel P Kavanagh, Niamh Hynes, Sherif Sultan
Carotid stump syndrome is defined as the persistence of retinal or cerebral ischaemic events with complete occlusion of the ipsilateral internal carotid artery. The aim of this retrospective cases series was to assess the outcomes for patients with carotid stump syndrome managed with surgical intervention. A series of 11 cases of carotid stump syndrome in nine patients presented to our tertiary vascular centre from October 2004 to February 2016. Indications for intervention were amaurosis fugax, transient ischaemic attacks and stroke...
2018: SAGE Open Medical Case Reports
Min-Woo Lee, Kyeung-Min Kim, Hyung-Bin Lim, Young-Joon Jo, Jung-Yeul Kim
AIM: To analyse the repeatability of vessel density (VD) measurements using optical coherence tomography angiography (OCTA) in patients with retinal diseases. METHODS: Two consecutive VD measurements using OCTA were analysed prospectively in patients with retinal diseases (diabetic macular oedema (DME), retinal vein occlusion (RVO) with macular oedema, epiretinal membrane (ERM), wet age-related macular degeneration (AMD)). The intraclass correlation coefficient (ICC), coefficient of variation (CV) and test-retest SD of VD measurements were assessed, and linear regression analyses were conducted to identify factors related to repeatability...
July 4, 2018: British Journal of Ophthalmology
Kang Wang, Khalil Ghasemi Falavarjani, Muneeswar G Nittala, Min Sagong, Charles C Wykoff, Jano van Hemert, Michael Ip, SriniVas R Sadda
Purpose: The purpose of this study was to compare the use of central and montaged ultra-wide-field fluorescein angiography (UWFFA) images for calculating the area of nonperfusion (NP) and ischemic index (ISI) in patients with retinal vein occlusion (RVO) and macular edema (ME) and to correlate these measurements with best-corrected visual acuity (BCVA) and central macular thickness (CMT). Methods: Thirty eyes of 30 RVO patients with recurrent ME were enrolled. Baseline UWFA images were sent to the Doheny Image Reading Center for quantitative analysis by certified graders...
July 2, 2018: Investigative Ophthalmology & Visual Science
Raphaelle Prevost, Guillaume Feugueur, Hervé Moizan, Pierre Keribin, Jihane Kimakhe, Alexis Veyssiere
Sickle cell disease, the most common genetic disease in the world, is a chronic hemolytic disease that can be complicated by severe vaso-occlusive pain crises resulting in tissue necrosis and even death. Due to its increasing incidence, oral surgeons will inevitably be faced with the management of these patients. To limit the risk of crises, our goal is to share recommendations for the management of sickle cell patients in oral surgery. The vaso-occlusive crises (VOC), heart attacks and chronic anemia endured by these patients cause chronic lesions in various organs...
June 27, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
Shashikant Sharma, Mujtaba A Khan, Alok Chaturvedi
BACKGROUND: This subgroup analysis of the RE-ENACT study evaluates the effectiveness of Razumab® (the world's first biosimilar of ranibizumab by Intas Pharmaceuticals Ltd.) in Indian patients with retinal vein occlusion (RVO). METHODS: The data on patients with RVO who had received ≥3 injections of Razumab® between January and August 2016 were analyzed. Endpoints were: improvement in best corrected visual acuity (BCVA), and a decrease in central macular thickness (CMT), intraretinal fluid (IRF), and subretinal fluid (SRF) from baseline at weeks 4, 8, and 12...
June 26, 2018: Ophthalmologica. Journal International D'ophtalmologie
Alberto Galvez-Ruiz, Alicia Galindo-Ferreiro, Anthony J Lehner, Igor Kozac
Cardiac myxomas are benign tumors of endocardial origin that usually occur in the left atrium. Trans-thoracic echocardiography is the diagnostic method of choice, and early surgical removal is the preferred method of treatment. We present a patient whose history of cerebral emboli and central retinal artery occlusion (CRAO) led to a diagnosis of cardiac myxoma. Neuroimaging studies showed multiple infarcts in the region of the left middle and anterior cerebral arteries. Ophthalmic examination showed gross retinal pallor compatible with left central retinal artery occlusion (CRAO)...
April 2018: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
Jian Chen, Weiqi Chen, Honghe Xia, Chuang Jin, Xuehui Lu, Haoyu Chen
Branch retinal vein occlusion (BRVO) may be complicated with retinal ischemia in some cases. The purpose of the current study is to investigate the relationship between optical intensity on optical coherence tomography (OCT) and retinal ischemia in BRVO. Twenty-seven eyes diagnosed with BRVO without macular edema were classified into two groups based on the presence or absence of retinal ischemia. The optical intensity of inner retinal layers and photoreceptor inner segment ellipsoid zone/retinal pigment epithelium layer (ISe/RPE) in the affected and unaffected regions were measured on OCT...
June 25, 2018: Scientific Reports
Isha Lohmror, Maya Hada, Vishal Agarwal, Kamlesh Khilnani
Avulsion of the optic nerve head is a rare and severe complication of ocular blunt trauma. Herein, we describe a case of 16-year-old boy, who presented with a rare combination of optic nerve avulsion associated with central retinal artery occlusion, following blunt trauma with a leather ball. This report highlights the potential blinding complication following rotational injury.
July 2018: Indian Journal of Ophthalmology
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