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Retinal occlusion

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https://www.readbyqxmd.com/read/28916115/-retinal-vein-occlusions
#1
REVIEW
A Pierru, J-F Girmens, E Héron, M Paques
Retinal venous occlusions comprise central retinal vein occlusion, hemiretinal vein occlusions, and branch retinal vein occlusions. They are associated with arterial hypertension and glaucoma. Retinal vein occlusions occur more frequently in males, at a median age of 55. The pathogenesis of retinal venous occlusions remains obscure. The clinical presentation of the disease is variable. In most cases, there is a unilateral visual loss over days with a painless, white and quiet eye. However, retinal venous occlusions may also present as an abrupt and profound loss of vision, or be asymptomatic...
September 12, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28914687/prevention-of-macular-edema-after-cataract-surgery
#2
Laura H P Wielders, Jan S A G Schouten, Rudy M M A Nuijts
PURPOSE OF REVIEW: Although cataract surgery can effectively restore visual function in many patients with cataract, pseudophakic cystoid macular edema (PCME) remains an important cause of suboptimal visual acuity. The present review provides an overview of the current literature on the prevention and treatment of PCME. RECENT FINDINGS: Optimal prevention of PCME starts preoperatively with a personalized risk assessment. Diabetes mellitus, retinal vein occlusion, epiretinal membrane, macular hole, and uveitis are the most important risk factors for developing cystoid macular edema after cataract surgery...
September 12, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28913517/intravitreal-injection-of-ziv-aflibercept-in-the-treatment-of-choroidal-and-retinal-vascular-diseases
#3
Kamran HodjatJalali, Shiva Mehravaran, Hooshang Faghihi, Hassan Hashemi, Pegah Kazemi, Hadith Rastad
PURPOSE: To investigate the short-term outcomes after intravitreal injection of ziv-aflibercept in the treatment of choroidal and retinal vascular diseases. METHODS: Thirty-four eyes of 29 patients with age-related macular degeneration (AMD), diabetic retinopathy, and retinal vein occlusion (RVO) received a single dose intravitreal injection of 0.05 ml ziv-aflibercept (1.25 mg). Visual acuity, spectral domain optical coherence tomography (SD-OCT) activity, and possible side effects were assessed before and at 1 week and 1 month after the intervention...
September 2017: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/28911993/ocular-manifestations-of-familial-transthyretin-amyloidosis
#4
Margaret M Reynolds, Kevin K Veverka, Morie A Gertz, Angela Dispenzieri, Steven R Zeldenrust, Nelson Leung, Jose S Pulido
PURPOSE: Among patients with familial amyloidosis, mutation in the transthyretin (TTR) protein is the most common type. Patients with TTR amyloidosis have been noted to have ocular, especially vitreous, involvement. In this report, an analysis of the types and frequency of ocular manifestations in TTR amyloidosis is presented. DESIGN: Observational case series. METHODS: Two hundred and sixty-three patients who presented to Mayo Clinic with TTR amyloidosis between January 1, 1970, and November 1, 2014, consented to be included in the Mayo Clinic amyloidosis database maintained by the Department of Hematology...
September 11, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28910435/repeatability-and-reproducibility-of-superficial-macular-retinal-vessel-density-measurements-using-optical-coherence-tomography-angiography-en-face-images
#5
Jianqin Lei, Mary K Durbin, Yue Shi, Akihito Uji, Siva Balasubramanian, Elmira Baghdasaryan, Mayss Al-Sheikh, Srinivas R Sadda
Importance: The repeatability and reproducibility of quantitative metrics from optical coherence tomographic angiography (OCTA) must be assessed before these data can be confidently interpreted in clinical research and practice. Objective: To evaluate the repeatability and reproducibility of OCTA-derived retinal vascular quantitative metrics. Design, Setting and Participants: In this cross-sectional study, 21 healthy volunteers (42 eyes) and 22 patients with retinal disease (22 eyes), including 14 with age-related macular degeneration, 3 with epiretinal membrane, 2 with diabetic retinopathy, 2 with myopic macular degeneration, and 1 with retinal vein occlusion, were enrolled...
September 14, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28904960/mystery-of-retinal-vein-occlusion-vasoactivity-of-the-vein-and-possible-involvement-of-endothelin-1
#6
REVIEW
Teruyo Kida
Retinal vein occlusion (RVO) is a common vascular disease of retina; however, the pathomechanism leading to RVO is not yet clear. In general, increasing age, hypertension, arteriosclerosis, diabetes mellitus, dyslipidemia, cardiovascular disorder, and cerebral stroke are systemic risk factors of RVO. However, RVO often occur in the unilateral eye and sometimes develop in young subjects who have no arteriosclerosis. In addition, RVO show different variations on the degrees of severity; some RVO are resolved without any treatment and others develop vision-threatening complications such as macular edema, combined retinal artery occlusion, vitreous hemorrhage, and glaucoma...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28902097/retinal-microvasculature-and-visual-acuity-after-intravitreal-aflibercept-in-eyes-with-central-retinal-vein-occlusion-an-optical-coherence-tomography-angiography-study
#7
Andrew Winegarner, Taku Wakabayashi, Chikako Hara-Ueno, Tatsuhiko Sato, Caleb Busch, Yoko Fukushima, Kaori Sayanagi, Kentaro Nishida, Hirokazu Sakaguchi, Kohji Nishida
PURPOSE: To investigate vascular perfusion and foveal avascular zone area in the superficial capillary plexus (SCP) and deep capillary plexus (DCP) after intravitreal aflibercept therapy in central retinal vein occlusion eyes and their association with best-corrected visual acuity. METHODS: Thirty-five subjects with central retinal vein occlusion and macular edema were evaluated. After macular edema resolution following intravitreal aflibercept, subjects underwent optical coherence tomography angiography to measure SCP and DCP perfusion and the foveal avascular zone within a 3 × 3-mm area...
September 7, 2017: Retina
https://www.readbyqxmd.com/read/28898259/association-between-retinal-vein-occlusion-and-an-increased-risk-of-acute-myocardial-infarction-a-nationwide-population-based-follow-up-study
#8
Yu-Yen Chen, Shwu-Jiuan Sheu, Hsiao-Yun Hu, Dachen Chu, Pesus Chou
OBJECTIVE: To investigate a possible association between retinal vein occlusion (RVO) and an increased risk of developing acute myocardial infarction (AMI). DESIGN: A population-based retrospective cohort study using the entire population of the Taiwan National Health Insurance Research Database (NHIRD) from 1st January, 2001 to 31st December, 2013. METHODS: A total of 37921 subjects with RVO were enrolled in the RVO group, and 113763 subjects without RVO were enrolled in the comparison group...
2017: PloS One
https://www.readbyqxmd.com/read/28895629/-novel-examination-procedures-for-the-assessment-of-retinal-artery-occlusion-by-oct-angiography
#9
Max Loidl, Christian Enders, Jens Ulrich Werner, Gerhard K Lang, Gabriele E Lang
Background Retinal artery occlusion (RAO) is the most common primary angiopathy of the retina. With an incidence of 0.01 - 0.15%, this it is a rather rare disease, but is associated with irreversible damage to the retina and a poor prognosis for visual acuity. Since the 1960s - when fluorescence angiography (FA) was developed -, there has been little change in diagnostic investigations. FA is still the standard procedure for the assessment of retinal artery occlusions. With the development of OCT angiography (OCT-A), new multimodal imaging procedures have become possible...
September 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28885997/susac-syndrome-the-first-case-report-in-peru
#10
Carolina Rivadeneira-Sotelo, María Meza Vega, Darwin Segura-Chávez, Sheila Castro-Suarez
Susac Syndrome is a rare entity, characterized by a triad of subacute encephalopathy, retinal artery occlusion and sensorineural hearing loss. It is more common in women and the age of onset fluctuates between 9-58 years of age. The pathogenesis is presented as microangiopathic changes at the cerebral, retinal and cochlear levels associated with an autoimmune mechanism. We present the case of a 31-year-old woman who started with a diffuse headache, puerile behavior, bradylalia and somnolence. As the disease progressed, she had auditory deficit and arterial obstruction of the right temporal retinal branch in retinal fluorescein angiography...
August 30, 2017: Medwave
https://www.readbyqxmd.com/read/28883712/integrated-results-from-the-copernicus-and-galileo-studies
#11
Amelie Pielen, W Lloyd Clark, David S Boyer, Yuichiro Ogura, Frank G Holz, Jean-Francois Korobelnik, Brigitte Stemper, Friedrich Asmus, Kay D Rittenhouse, Christiane Ahlers, Robert Vitti, Namrata Saroj, Oliver Zeitz, Julia A Haller
OBJECTIVES: To report on the efficacy and safety of intravitreal aflibercept in patients with macular edema secondary to central retinal vein occlusion (CRVO) in an integrated analysis of COPERNICUS and GALILEO. PATIENTS AND METHODS: Patients were randomized to receive intravitreal aflibercept 2 mg every 4 weeks or sham injections until week 24. From week 24 to week 52, all intravitreal aflibercept-treated patients in both studies and sham-treated patients in COPERNICUS were eligible to receive intravitreal aflibercept based on prespecified criteria...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28882392/fundus-autofluorescence-in-retinal-artery-occlusion-a-more-precise-diagnosis
#12
J-L Bacquet, M Sarov-Rivière, C Denier, G Querques, B Riou, L Bonin, E Barreau, M Labetoulle, A Rousseau
IMPORTANCE: Retinal artery occlusion (RAO) is a medical emergency associated with a high risk of cerebral vascular accident and other cardiovascular events. Among patients with non-arteritic RAO, a retinal embolus is observed in approximately 40% of cases. Fundus examination and retinography are not reliable to predict the nature of the emboli. OBSERVATIONS: We report three consecutive cases of central and branch RAO that were investigated with fundus autofluorescence, fluorescein angiography and color retinal photographs...
September 4, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28878627/optic-nerve-degeneration-after-retinal-ischemia-reperfusion-in-a-rodent-model
#13
Marina Renner, Gesa Stute, Mohammad Alzureiqi, Jacqueline Reinhard, Susanne Wiemann, Heiko Schmid, Andreas Faissner, H Burkhard Dick, Stephanie C Joachim
Retinal ischemia is a common pathomechanism in many ocular disorders such as age-related macular degeneration (AMD), diabetic retinopathy, glaucoma or retinal vascular occlusion. Several studies demonstrated that ischemia/reperfusion (I/R) leads to morphological and functional changes of different retinal cell types. However, little is known about the ischemic effects on the optic nerve. The goal of this study was to evaluate these effects. Ischemia was induced by raising the intraocular pressure (IOP) in one eye of rats to 140 mmHg for 1 h followed by natural reperfusion...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28865424/prevalence-pattern-and-risk-factors-of-retinal-vein-occlusion-in-an-elderly-population-in-nepal-the-bhaktapur-retina-study
#14
Raba Thapa, Sanyam Bajimaya, Govinda Paudyal, Shankar Khanal, Stevie Tan, Suman S Thapa, Ger van Rens
BACKGROUND: This study aims to explore the prevalence, pattern and risk factors of retinal vein occlusion (RVO) in an elderly population of Nepal. METHOD: One thousand eight hundred sixty subjects of age 60 years and above were enrolled in a population-based, cross-sectional study. Detailed history, visual acuity, anterior segment and posterior segment examinations were done. Blood pressure, non-fasting blood sugar, body mass index and abdominal girth were measured...
September 2, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28862735/author-s-reply-to-comments-to-real-world-outcomes-of-anti-vegf-treatment-for-retinal-vein-occlusion-in-portugal
#15
Sara Vaz-Pereira, Inês P Marques, Rita Flores
No abstract text is available yet for this article.
August 11, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28860707/widening-use-of-dexamethasone-implant-for-the-treatment-of-macular-edema
#16
REVIEW
Vincenza Bonfiglio, Michele Reibaldi, Matteo Fallico, Andrea Russo, Alessandra Pizzo, Stefano Fichera, Carlo Rapisarda, Iacopo Macchi, Teresio Avitabile, Antonio Longo
Sustained-release intravitreal 0.7 mg dexamethasone (DEX) implant is approved in Europe for the treatment of macular edema related to diabetic retinopathy, branch retinal vein occlusion, central retinal vein occlusion, and non-infectious uveitis. The implant is formulated in a biodegradable copolymer to release the active ingredient within the vitreous chamber for up to 6 months after an intravitreal injection, allowing a prolonged interval of efficacy between injections with a good safety profile. Various other ocular pathologies with inflammatory etiopathogeneses associated with macular edema have been treated by DEX implant, including neovascular age-related macular degeneration, Irvine-Gass syndrome, vasoproliferative retinal tumors, retinal telangiectasia, Coats' disease, radiation maculopathy, retinitis pigmentosa, and macular edema secondary to scleral buckling and pars plana vitrectomy...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28860042/oct-angiography-and-ultra-widefield-fluorescein-angiography-for-early-detection-of-adolescent-sickle-retinopathy
#17
Daniel A Pahl, Nancy S Green, Monica Bhatia, Margaret T Lee, Jonathan S Chang, Maureen Licursi, Courtney Briamonte, Elana Smilow, Royce W S Chen
PURPOSE: Using standard screening techniques, sickle retinopathy reportedly occurs in 10% of adolescents with sickle cell disease (SCD). We performed a prospective, observational clinical study to determine if ultra-widefield fluorescein angiography (UWFA), spectral-domain optical coherence tomography (SD-OCT) and optical coherence tomography angiography (OCT-A) detect more frequent retinopathy in adolescents with SCD. DESIGN: Cross-sectional study. METHODS: Setting: Institutional...
August 28, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28856036/optical-coherence-tomography-angiography-of-retinal-vascular-occlusions-produced-by-imaging-guided-laser-photocoagulation
#18
Brian T Soetikno, Xiao Shu, Qi Liu, Wenzhong Liu, Siyu Chen, Lisa Beckmann, Amani A Fawzi, Hao F Zhang
Retinal vascular occlusive diseases represent a major form of vision loss worldwide. Rodent models of these diseases have traditionally relied upon a slit-lamp biomicroscope to help visualize the fundus and subsequently aid delivery of high-power laser shots to a target vessel. Here we describe a multimodal imaging system that can produce, image, and monitor retinal vascular occlusions in rodents. The system combines a spectral-domain optical coherence tomography system for cross-sectional structural imaging and three-dimensional angiography, and a fluorescence scanning laser ophthalmoscope for Rose Bengal monitoring and high-power laser delivery to a target vessel...
August 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28853639/acute-vision-loss-in-systemic-lupus-erythematosus-bilateral-combined-retinal-artery-and-vein-occlusion-as-a-catastrophic-form-of-clinical-flare
#19
M Akhlaghi, B Abtahi-Naeini, M Pourazizi
Presentation of a combination of branch retinal artery occlusion (BRAO)/central retinal artery occlusion (CRAO) and central retinal vein occlusion (CRVO) in systemic lupus erythematosus (SLE) is extremely rare. Herein, we have presented the case of a 29-year-old female with SLE, who simultaneously developed bilateral CRVO and BRAO/CRAO in the absence of antiphospholipid syndrome (APS) as a catastrophic form of clinical flare. A combinatorial diagnosis of CRVO and BRAO/CRAO should be considered during clinical flare-up in a patient with SLE who presents with rapidly progressive visual loss...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28840855/comments-on-treatment-patterns-of-ranibizumab-intravitreal-injection-and-dexamethasone-intravitreal-implant-for-retinal-vein-occlusion-in-the-usa
#20
M A Williams, C Shute, S Wright
No abstract text is available yet for this article.
August 25, 2017: Eye
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