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Retinal occlusion

Allison Low, Ambar Faridi, Kavita V Bhavsar, Glenn C Cockerham, Michele Freeman, Rochelle Fu, Robin Paynter, Karli Kondo, Devan Kansagara
Intravitreal antivascular endothelial growth factor (VEGF) agents are widely used to treat ocular conditions but the benefits and harms of these treatments are uncertain. We conducted a systematic review to compare the effects of aflibercept, bevacizumab and ranibizumab on best-corrected visual acuity (BCVA) changes, quality of life and ocular or systemic adverse events in patients with neovascular age-related macular degeneration (NVAMD), diabetic macular oedema (DME) and central or branch retinal vein occlusion (RVO)...
November 8, 2018: British Journal of Ophthalmology
Jose Garcia-Arumi, Francisco Gómez-Ulla, Navea Amparo, Enrique Cervera, Alex Fonollosa, Luis Arias, Javier Araiz, Juan Donate, Marta Suárez de Figueroa, Lucia Manzanas, Jaume Crespí, Roberto Gallego
Objectives: To evaluate efficacy and safety of an aflibercept treat-and-extend (TAE) regimen in patients with macular oedema (MO) secondary to central retinal vein occlusion (CRVO). Design Setting and Patients: Phase IV, prospective, open-label, single-arm trial in 11 Spanish hospitals. Treatment-naïve patients with <6 month diagnosis of MO secondary to CRVO and best-corrected visual acuity (BCVA) of 73-24 ETDRS letters were included between 23 January 2015 and 17 March 2016...
2018: Journal of Ophthalmology
Li Hui Li, Hou Bin Huang, Zhi Ye Chen
Conventional contrast-enhanced T1WI is a useful tool for evaluating the choroid but can not be used to evaluate the retina due to its small blood supply. Contrast-enhanced T2 fluid-attenuated inversion recovery imaging(CE-T2FLAIR)is sensitive to low-concentration MRI contrast;however,its role in the diagnosis of macular edema has not been described. A patient with macular edema caused by retinal vein occlusion was diagnosed by CE-T2FLAIR in the Hainan Branch of Chinese PLA General Hospital from July 20,2017 to August 4,2017,and our findings confirmed that CE-T2FLAIR could provide valuable imaging evidence for the diagnosis and evaluation of macular edema...
October 30, 2018: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
Isabeau Houben, Julie De Zaeytijd, Catherine Deghislage, N Andrew Frost, Ivo Nijs, Joachim Van Calster
PURPOSE: To evaluate the efficacy of dexamethasone intravitreal implants (DEX implant) in patients with treatment-resistant macular edema (ME) owing to branch and central retinal vein occlusion (BRVO/CRVO), and the influence of prior vitrectomy on this treatment. METHODS: Multicenter retrospective chart review was performed on 40 CRVO and 32 BRVO eyes with persistent ME despite intravitreal anti-vascular endothelial growth factor agents and/or intravitreal triamcinolone, and/or laser therapy...
November 7, 2018: Journal of Ocular Pharmacology and Therapeutics
Gal Antman, Shay Keren, Shimon Kurtz, Amir Rosenblatt, Rony Rachmiel
PURPOSE: The aim of this study was to evaluate pseudoexfoliation (PXF) as an independent risk factor for the occurrence of retinal vein occlusion (RVO). METHODS: This is a retrospective cohort study on the records of 300 PXF glaucoma patients (PXF group), 300 non-PXF glaucoma patients, and 599 nonglaucoma non-PXF (nGnP group) patients. RESULTS: Multivariate analysis resulted in a significant probability for RVO in the PXF (p = 0.005; OR 2...
November 2, 2018: Ophthalmologica. Journal International D'ophtalmologie
Yijun Hu, Yang Yu, Zhanyun Bu, Biyun Cun, Yi Gong, Dongli Li, Jianhua Li, Li Lu, Guodong Li, Ling Yuan
PURPOSE: To investigate the levels of systemic heparanase, inflammatory markers, and coagulation factor activities in patients with retinal vein occlusion (RVO). METHODS: This prospective study included 18 patients with central RVO, 22 patients with branch RVO, and 40 patients with age-related cataract as the control group. Serum heparanase protein levels and activities were measured by ELISA and a heparan degrading enzyme assay kit, respectively. Serum levels of MMP-2, MMP-9, TLR-2, and TLR-4 were measured by ELISA kits...
October 29, 2018: Retina
Limin Liu, Chunmei Hu, Lei Chen, Yuedong Hu
The purpose of this study is to describe the effects and complications of photodynamic therapy (PDT) on Chinese patients with circumscribed choroidal hemangioma (CCH). In this retrospective study, 22 CCH patients who underwent PDT performed 15 min after the injection of intravenous verteporfin (6 mg/m2)with multiple 83-second laser spots at 689 nm (50 J/cm2) were studied. Fluorescein angiography and/or indocyanine green angiography, B-scan ultrasonography and optical coherence tomography were performed in all patients...
October 28, 2018: Photodiagnosis and Photodynamic Therapy
Yen-Lin Chen, Yi Ren, Wenjuan Xu, Robert H Rosa, Lih Kuo, Travis W Hein
Purpose: Endothelin-1 (ET-1) is a potent vasoconstrictor peptide implicated in retinal venous pathologies such as diabetic retinopathy and retinal vein occlusion. However, underlying mechanisms contributing to venular constriction remain unknown. Thus, we examined the roles of ET-1 receptors, extracellular calcium (Ca2+), L-type voltage-operated calcium channels (L-VOCCs), Rho kinase (ROCK), and protein kinase C (PKC) in ET-1-induced constriction of retinal venules. Methods: Porcine retinal venules were isolated and pressurized for vasoreactivity study using videomicroscopic techniques...
October 1, 2018: Investigative Ophthalmology & Visual Science
Christian K Brinkmann, Petrus Chang, Tina Schick, Britta Heimes, Jessica Vögeler, Birgit Haegele, Bernd Kirchhof, Frank G Holz, Daniel Pauleikhoff, Focke Ziemssen, Sandra Liakopoulos, Georg Spital, Steffen Schmitz-Valckenberg
BACKGROUND: The ORCA module of the non-interventional OCEAN study investigated the use of retinal imaging diagnostics in the clinical treatment of patients undergoing vascular endothelial growth factor (VEGF) inhibitor treatment as part of routine clinical care. This article analyzes the agreement between the diagnosis documented by the treating ophthalmologist and the evaluation of reading centers at baseline as well as the effect on the response to treatment during the course. METHODS: A total of 396 patients (age 75...
October 26, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
Lasse Jørgensen Cehofski, Anders Kruse, Svend Kirkeby, Alexander Nørgård Alsing, Jonas Ellegaard Nielsen, Kentaro Kojima, Bent Honoré, Henrik Vorum
Retinal vein occlusion (RVO) is a common retinal vascular disease. RVO may be complicated by pronounced ischemia that often leads to severe loss of visual function. The present work aimed at studying the retinal proteome of RVO complicated by ischemia. In six Danish Landrace pigs RVO was induced with argon laser in the right eye of each animal. As four retinal veins were occluded, the RVO best corresponded to a central retinal vein occlusion (CRVO). Left control eyes received a similar laser treatment without inducing occlusion...
October 25, 2018: International Journal of Molecular Sciences
Jonathan F Russell, Nathan L Scott, Luis J Haddock, Alexander M Eaton, Harry W Flynn
Purpose: To report two cases of central retinal artery occlusion (CRAO) associated with vitreoretinal surgery. Observations: Two patients underwent vitreoretinal surgery and were diagnosed with CRAO on postoperative day one. Both had received retrobulbar anesthetic blocks, followed by pars plana vitrectomy in one patient and scleral buckling in the other patient. Best-corrected visual acuity at last follow-up was 20/40 and 20/400. Conclusions/Importance: CRAO is a rare but serious adverse event after vitreoretinal surgery...
December 2018: American Journal of Ophthalmology Case Reports
Yih-Jing Lee, Chia-Ying Ke, Ni Tien, Po-Kang Lin
Hyperhomocysteinemia is a risk factor for atherosclerosis, which may also be associated with retinal vascular disease, diabetic retinopathy, retinal vein occlusion, and glaucoma. For this study, we established a hyperhomocysteinemia animal model to explore homocysteine (hcy)-related choroidal angiogenesis and possible related factors. We injected Sprague Dawley (SD) rats with different concentrations of hcy and performed color fundus imaging, fluorescein angiography, image-guided optical coherence tomography, and retinal histology to observe the retinal and choroidal changes...
October 25, 2018: Scientific Reports
F Kaya, I Kocak, A Aydin, H Baybora, H Koc, Y Karabela
PURPOSE: To evaluate the efficacy of switching treatment from intravitreal ranibizumab to intravitreal aflibercept on the treatment of refractory macular edema secondary to central retinal vein occlusion (CRVO). METHODS: In this retrospective study; 12 eyes with refractory macular edema secondary to CRVO after multiple monthly repeated intravitreal 0.5mg/0.05mL ranibizumab injections prior to switching therapy to intravitreal 2mg/0.05mL aflibercept, between March 2012 and April 2016 were reviewed...
October 22, 2018: Journal Français D'ophtalmologie
Taneto Tomiyasu, Yoshio Hirano, Norihiro Suzuki, Yuya Esaki, Yusuke Yasuda, Akiyoshi Uemura, Tsutomu Yasukawa, Munenori Yoshida, Yuichiro Ogura
PURPOSE: To study the structural and functional changes of retinal ischemia and investigate their association with macular edema (ME) or microaneurysm (MA) formation in eyes with retinal vein occlusion (RVO). METHODS: Sixty eyes of 30 patients (27 eyes with branch [b]RVO, 3 with central RVO, and 30 fellow eyes) were retrospectively reviewed. Optical coherence tomography (OCT), OCT angiography (OCTA), and microperimetry were performed simultaneously to measure retinal thickness and sensitivity...
October 25, 2018: Ophthalmic Research
Errol W Chan, Vincent Sun, Mohab Eldeeb, Michael A Kapusta
PURPOSE: To describe a case of Epstein-Barr virus (EBV)-associated acute retinal necrosis (ARN) in an immunocompetent patient and to summarize the clinical features of published molecularly confirmed EBV-ARN cases. METHODS: Case report and literature review. RESULTS: An 83-year-old immunocompetent woman with unilateral ARN presented with visual acuity of light perception. Oral valacyclovir was started. One week later, vitrectomy was conducted for worsening inflammation...
October 23, 2018: Retinal Cases & Brief Reports
Francesco Romano, Giorgia Carlotta Albertini, Alessandro Arrigo, Maurizio Battaglia Parodi, Francesco Bandello
INTRODUCTION: Disorders of vitreoretinal interface represent a rare complication of intravitreal dexamethasone implant injection. Our report describes a new mechanism resulting in cystic roof collapse and emphasizes the importance of a strict optical coherence tomography evaluation during therapy with dexamethasone injection in order to prevent this rare complication. PURPOSE: To describe the rupture of the cystic roof following treatment with sustained-release dexamethasone implant intravitreal injection (Ozurdex; Allergan, Irvine) for macular edema...
October 24, 2018: European Journal of Ophthalmology
K Bailey Freund, David Sarraf, Belinda C S Leong, Sean Thomas Garrity, Kiran K Vupparaboina, Kunal K Dansingani
Importance: Analysis of collateral vessel formation following retinal vein occlusion may advance our understanding of the venous outflow anatomy in the macula. Objective: To determine the location of collateral vessels with optical coherence tomography (OCT) angiography imaging. Design, Setting, and Participants: Observational retrospective cohort study. Collateral vessel formation was studied with OCT angiography (OCTA) in patients with retinal vein occlusion (RVO)...
November 1, 2018: JAMA Ophthalmology
Ian L McAllister, Lynne A Smithies, Fred K Chen, David A Mackey, Paul G Sanfilippo
Importance: Adding a laser-induced chorioretinal anastomosis (L-CRA) to current treatments for central retinal vein occlusion (CRVO) may improve outcomes and lessen therapy burdens. Objective: To determine the 2-year efficacy of intravitreal ranibizumab with an L-CRA vs ranibizumab alone for patients with macular edema caused by CRVO. Design, Setting, and Participants: In this randomized clinical trial conducted at a single university clinic from March 2012 to June 2015, 58 participants with macular edema caused by CRVO were randomized 1:1 to either an L-CRA or sham procedure at baseline...
October 18, 2018: JAMA Ophthalmology
Michael S Ip
No abstract text is available yet for this article.
October 18, 2018: JAMA Ophthalmology
Lior Lipsky, Graham Barrett
Postoperative endophthalmitis is a severe complication which may result in loss of vision. Intracameral antibiotics have been shown to reduce the risk of this complication and are extensively used worldwide, with vancomycin, cefuroxime and moxifloxacin most commonly used. Choices in Australia are currently limited to vancomycin and cefazolin, since cefuroxime and moxifloxacin are not available. Vancomycin has been safely and effectively used in our department for more than two decades. Recent publications have risen concerns regarding the association of Haemorrhagic Occlusive Retinal Vasculitis a potentially blinding complication with intracameral vancomycin...
October 21, 2018: Clinical & Experimental Ophthalmology
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