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Retinal occlusion

Kelsey A Roelofs, Dean Eliott, Suzanne K Freitag
No abstract text is available yet for this article.
October 2018: Ophthalmology
Bekir Selim Bagli, Sadik Görkem Çevik, Mediha Tok Çevik
Background: Central retinal artery occlusion (CRAO) is a rare and serious ophthalmologic emergency with a bad prognosis. Hyperbaric oxygen (HBO2) treatment has been reported to improve visual acuity of CRAO patients. However, there are unknown variables for HBO2 treatment such as initiation period, number of sessions and efficacy. In this study, we aimed to investigate efficacy of HBO2 treatment in CRAO patients. Methods: Patients who had been diagnosed with CRAO and referred to our Hyperbaric Oxygen Treatment Unit with the indication of HBO2 treatment were included in the study...
July 2018: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
Ke Xu, Lingling Wu, Zhizhong Ma, Yuling Liu, Fang Qian
PURPOSE: To investigate the frequency of primary angle closure (PAC) and primary angle closure glaucoma (PACG) in patients with retinal vein occlusion (RVO) based on a hospital population. METHODS: A total of 375 consecutive cases newly diagnosed with RVO by fluorescein fundus angiography at a single eye centre in Peking were reviewed. Gonioscopy was performed in all patients. Glaucoma was diagnosed according to the criteria of the International Society of Geographical and Epidemiological Ophthalmology...
September 21, 2018: Acta Ophthalmologica
Rie Osaka, Koichiro Manabe, Saki Manabe, Yuki Nakano, Yukari Takasago, Chieko Shiragami, Kazuyuki Hirooka, Yuki Muraoka, Akitaka Tsujikawa
PURPOSE: To investigate longitudinal changes in metamorphopsia associated with branch retinal vein occlusion. METHODS: In this prospective observational case series, we included 32 eyes (32 patients) with branch retinal vein occlusion and acute macular edema. Eyes were treated as needed with intravitreal ranibizumab injections for 12 months. At baseline and 1, 6, and 12 months after initiating treatment, metamorphopsia was quantified using M-CHARTS. Retinal morphology was examined through optical coherence tomography...
2018: PloS One
Michael J Venincasa, Ajay E Kuriyan, Jayanth Sridhar
PURPOSE: To examine the relationship between industry funding and outcome reporting bias in high-quality studies investigating the use of intravitreal anti-vascular endothelial growth factor (VEGF) agents for patients with macular oedema secondary to branch or central retinal vein occlusion (RVO). METHODS: This systematic review in PubMed and Ovid MEDLINE examined all randomized clinical trials and meta-analyses published in journals with impact factor of ≥2 that investigated effectiveness of intravitreal anti-VEGF therapy in patients with RVO...
September 19, 2018: Acta Ophthalmologica
Jonathan Naysan, Kunal K Dansingani, Chandrakumar Balaratnasingam, Sarah Mrejen, Steven Levasseur, Andrew Merkur, Lawrence A Yannuzzi
PURPOSE: To report the posterior segment and retinal vascular manifestations of calcific uremic arteriolopathy (calciphylaxis). Clinical findings are correlated with multimodal imaging results. METHODS: Observational case report. RESULTS: A 65-year-old white woman on hemodialysis was referred for assessment of poor vision bilaterally. Clinical examination demonstrated a crystalline retinopathy with stigma of previous retinal arterial occlusion...
October 2018: Retinal Cases & Brief Reports
Xue-Li Du, Wen-Bo Li, Bo-Jie Hu
Artificial intelligence is a general term that means to accomplish a task mainly by a computer, with the least human beings participation, and it is widely accepted as the invention of robots. With the development of this new technology, artificial intelligence has been one of the most influential information technology revolutions. We searched these English-language studies relative to ophthalmology published on PubMed and Springer databases. The application of artificial intelligence in ophthalmology mainly concentrates on the diseases with a high incidence, such as diabetic retinopathy, age-related macular degeneration, glaucoma, retinopathy of prematurity, age-related or congenital cataract and few with retinal vein occlusion...
2018: International Journal of Ophthalmology
Alper Halil Bayat, Akın Çakır, Şeyma Gülcenur Özturan, Selim Bölükbaşı, Burak Erden, Mustafa Nuri Elçioğlu
AIM: To compare three initial monthly intravitreal ranibizumab (IVR) injections followed by pro re nata (PRN) dosing with one initial monthly IVR injections followed by PRN dosing for macular edema (ME) secondary to branch retinal vein occlusion (BRVO). METHODS: Forty-two eyes of 42 patients who had IVR injections for BRVO were retrospectively studied. Eighteen eyes received 1 initial IVR injection (1+PRN group) and 24 eyes received 3 monthly IVR injections (3+PRN)...
2018: International Journal of Ophthalmology
Nikolaus Feucht, Daniel Zapp, Lukas Reznicek, Chris P Lohmann, Mathias Maier, Christian S Mayer
AIM: To describe retinal findings of various imaging modalities in acute retinal ischemia. METHODS: Fluorescein angiography (FA), spectral domain optical coherence tomography (SD-OCT), OCT-angiography (OCT-A) and fundus autofluorescence (FAF) images of 13 patients (mean age 64y, range 28-86y) with acute retinal ischemia were evaluated. Six suffered from branch arterial occlusion, 2 had a central retinal artery occlusion, 2 had a combined arteriovenous occlusions, 1 patient had a retrobulbar arterial compression by an orbital haemangioma and 2 patients showed an ocular ischemic syndrome...
2018: International Journal of Ophthalmology
Sawsan S Bakri, Deema Jomar, Sulaiman M Alsulaiman, Marwan A Abouammoh
A 9-year-old boy with the diagnosis of Sturge-Weber Syndrome, and port-wine stain involving the right side of the face, presented with acute visual loss of the right eye. Examination revealed a high intraocular pressure and a combined cilioretinal artery and inferior hemi-retinal vein occlusion in the right eye. Systemic work-up was negative. After controlling the intraocular pressure, gradual improvement of vision was noticed with simultaneous disappearance of signs of vascular occlusion.
July 2018: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
Xinyue Yang, Yan Cheng, Guanfang Su
Angiopoietin-like protein 4 is a multifunctional cytokine regulating vascular permeability, angiogenesis, and inflammation. Dysregulations on these responses contribute to the pathogenesis of ischemic retinopathies such as diabetic retinopathy, age-related macular degeneration, retinal vein occlusion and sickle cell retinopathy. However, the role of ANGPTL4 in these diseases remains controversial. Here, we summarize the functional mechanisms of ANGPTL4 in several diseases. We highlight original studies that provide detailed data about the mechanisms of action for ANGPTL4, its applications as a diagnostic or prognostic biomarker, and its use as a potential therapeutic target...
September 17, 2018: Bioscience Reports
Felipe F Conti, Jason M Young, Fabiana Q Silva, Eduardo B Rodrigues, Rishi P Singh
BACKGROUND AND OBJECTIVE: To evaluate the repeatability of retinal thickness and vascular density measurements using split-spectrum amplitude-decorrelation angiography (SSADA) with optical coherence tomography (OCT). PATIENTS AND METHODS: Forty patients were divided into seven categories according to their diagnosis: no retinopathy (control), retinal vein occlusion, diabetes with no retinopathy, diabetes with retinopathy, non-exudative age-related macular degeneration (AMD), exudative AMD, and epiretinal membrane...
September 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
Kornwipa Hemarat, Jacquelyn D Kemmer, Travis C Porco, Alexander M Eaton, Rahul N Khurana, Jay M Stewart
BACKGROUND AND OBJECTIVES: To determine the rate of ocular hypertension (OHT) after dexamethasone intravitreal implant in routine clinical practice and identify patient characteristics associated with a risk for glaucoma surgery. PATIENTS AND METHODS: The charts of 260 eyes from 221 patients with diabetic macular edema, retinal vein occlusion, uveitis, and macular edema secondary to various causes treated with one or more dexamethasone implants were reviewed. Intraocular pressure (IOP), medications, and glaucoma interventions were collected before and after implantation...
September 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
Touka Banaee, Rishi P Singh, Kathryn Champ, Felipe F Conti, Karen Wai, Jim Bena, Lucas Beven, Justis P Ehlers
Purpose: To evaluate the association of baseline ellipsoid zone (EZ) parameters on optical coherence tomography (OCT) as calculated by a semi-automated computer algorithm with baseline visual acuity in eyes with retinal vein occlusion (RVO). Design: Retrospective consecutive case series. Subjects: Patients affected by RVO presenting from January 2011 to December 2014. Methods: Baseline demographics, clinical characteristics, and SD-OCT data at presentation were collected...
August 2018: Ophthalmology Retina
Amir H Kashani, Kyle M Green, Julie Kwon, Zhongdi Chu, Qinqin Zhang, Ruikang K Wang, Sean Garrity, David Sarraf, Carl B Rebhun, Nadia K Waheed, Karen B Schaal, Marion R Munk, Sarra Gattoussi, K Bailey Freund, Fang Zheng, Guanghui Liu, Philip J Rosenfeld
Objective: To characterize features of extra-vascular optical coherence tomography angiography (OCTA) signals corresponding to hyperreflective intraretinal fluid across various exudative maculopathies. Design: Multicenter, retrospective, observational study. Participants: Eyes with various forms of exudative maculopathy including diabetic retinopathy (DR), retinal vein occlusion (RVO), and neovascular-age related macular degeneration (nvAMD)...
July 2018: Ophthalmology Retina
Jennifer Enright, Richard Schroeder, James R Waymack, Gregg Lueder, Rithwick Rajagopal
No abstract text is available yet for this article.
June 2018: Ophthalmology Retina
Cheng-Mao Lin, Paul M Titchenell, Jason M Keil, Adolfo Garcia-Ocaña, Mark T Bolinger, Steven F Abcouwer, David A Antonetti
Changes in permeability of retinal blood vessels contribute to macular edema and the pathophysiology of numerous ocular diseases, including diabetic retinopathy, retinal vein occlusions, and macular degeneration. Vascular endothelial growth factor (VEGF) induces retinal permeability and macular thickening in these diseases. However, inflammatory agents, such as tumor necrosis factor-α (TNF-α), also may drive vascular permeability, specifically in patients unresponsive to anti-VEGF therapy. Recent evidence suggests VEGF and TNF-α induce permeability through distinct mechanisms; however, both require the activation of atypical protein kinase C (aPKC)...
September 12, 2018: American Journal of Pathology
Alexander Böker, Ira Seibel, Anne Rübsam, Antonia M Joussen, Oliver Zeitz
BACKGROUND: In several diseases such as diabetic retinopathy and retinal vein occlusion, relevant pathophysiological changes take place in the retinal periphery. These changes may determine the prognosis and outcomes of therapy. Recent ultra-wide-angle camera systems promise improved and simplified visualisation of the outer periphery of the retina. This could potentially lead to novel clinical applications of these methods, with potential impact on therapy decisions. MATERIAL AND METHODS: Literature and database research on ultra-wide imaging for diabetic retinopathy and retinal vein occlusion...
September 2018: Klinische Monatsblätter Für Augenheilkunde
Lauren K Wareham, Ana C Dordea, Grigorij Schleifer, Vincent Yao, Annabelle Batten, Fei Fei, Joseph Mertz, Meredith Gregory-Ksander, Louis R Pasquale, Rebecca M Sappington, Emmanuel S Buys
The nitric oxide - guanylyl cyclase-1 - cyclic guanylate monophosphate (NO-GC-1-cGMP) pathway has emerged as a potential pathogenic mechanism for glaucoma, a common intraocular pressure (IOP)-related optic neuropathy characterized by the degeneration of retinal ganglion cells (RGCs) and their axons in the optic nerve. NO activates GC-1 to increase cGMP levels, which are lowered by cGMP-specific phosphodiesterase (PDE) activity. This pathway appears to play a role in both the regulation of IOP, where reduced cGMP levels in mice leads to elevated IOP and subsequent RGC degeneration...
September 10, 2018: Neurobiology of Disease
Peijie Huang, Ailin Liu, Hui Ren, Kang Xue
PURPOSE: This study aimed to evaluate the effects of retinal artery occlusions caused by cosmetic facial filler injections on the retrobulbar blood flow parameters. METHODS: This was a retrospective, noncomparative case series. Ten consecutive patients with fundus artery occlusions caused by facial filler injections were evaluated using color Doppler flow imaging (CDFI). The peak systolic velocity and end diastolic velocity of the ophthalmic artery, central retinal artery, and posterior ciliary arteries were determined...
September 4, 2018: Ophthalmic Plastic and Reconstructive Surgery
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