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https://read.qxmd.com/read/34910332/european-recommendations-for-management-of-immune-checkpoint-inhibitors-derived-dermatologic-adverse-events-the-eadv-task-force-dermatology-for-cancer-patients-position-statement
#1
JOURNAL ARTICLE
Z Apalla, V Nikolaou, D Fattore, G Fabbrocini, A Freites-Martinez, P Sollena, M Lacouture, L Kraehenbuehl, A Stratigos, K Peris, E Lazaridou, B Richert, E Vigarios, J Riganti, B Baroudjian, A Filoni, R Dodiuk-Gad, C Lebbé, V Sibaud
The introduction of immune checkpoint inhibitors (ICIs) opened a new era in oncologic therapy. The favourable profile of ICIs in terms of efficacy and safety can be overshadowed by the development of immune-related adverse events (irAEs). Dermatologic irAEs (dirAEs) appear in about 40% of patients undergoing immunotherapy and mainly include maculopapular, psoriasiform, lichenoid and eczematous rashes, auto-immune bullous disorders, pigmentary disorders, pruritus, oral mucosal lesions, hair and nail changes, as well as a few rare and potentially life-threatening toxicities...
March 2022: Journal of the European Academy of Dermatology and Venereology: JEADV
https://read.qxmd.com/read/34713494/psoriasiform-dermatitis-following-intravenous-immunoglobulin-therapy-a-case-series
#2
Tyler J Willenbrink, India S Robinson, Jessica S Connett, Lara Wine Lee
Intravenous immunoglobulin (IVIg) is a frequently used treatment modality in the pediatric inpatient population for acute diseases such as Kawasaki disease and Stevens-Johnson syndrome. There are few reported cutaneous adverse events after IVIg in the pediatric population. Here, we present two patients with psoriasiform dermatitis appearing after IVIg treatment for two different disease processes, Kawasaki disease and mycoplasma-associated mucositis, suggesting an association with the treatment instead of the disease process...
November 2021: Pediatric Dermatology
https://read.qxmd.com/read/33715172/five-year-survival-with-nivolumab-in-previously-untreated-japanese-patients-with-advanced-or-recurrent-malignant-melanoma
#3
MULTICENTER STUDY
Hisashi Uhara, Yoshio Kiyohara, Jiro Uehara, Yasuhiro Fujisawa, Tatsuya Takenouchi, Masaki Otsuka, Hiroshi Uchi, Satoshi Fukushima, Hironobu Minami, Masahiro Hatsumichi, Naoya Yamazaki
We report the 5-year follow-up results from a single-arm, open-label, multicenter phase II study (ONO-4538-08) conducted in Japan. Twenty-four patients with treatment-naïve, recurrent, or unresectable stage III/IV malignant melanoma received 3 mg/kg nivolumab every 2 weeks until progressive disease or unacceptable toxicity occurred. The 5-year overall survival (OS) rate was 26.1%. Five years after the start of nivolumab treatment, there were six survivors. The 5-year OS rate was 66.7% for patients with a superficial spreading type, 14...
May 2021: Journal of Dermatology
https://read.qxmd.com/read/33442352/an-intriguing-case-of-ectopic-benign-migratory-glossitis-resembling-secondary-syphilis-a-case-report
#4
Corolina Leone, Norberto Sugaya, Dante Migliari
Oral mucosal lesions presenting as erythematous patches usually pose difficulties for a clinical diagnosis. They elicit an array of differential diagnosis that mainly includes oral candidosis, contact mucosal reaction, oral lichenoid lesion, oral psoriasiform, autoimmune disease, and, not to forget, secondary syphilis. In this present case, all those above-mentioned possibilities were ruled out, while secondary syphilis stood as the main diagnosis. As this was also later excluded by a negative serological treponemal test, the final diagnosis rested on an ectopic manifestation of benign migratory glossitis (BMG), whose diagnosis was based on the clinical aspects of the lesions, along with their spontaneous disappearance in a short period of time (a hallmark of this condition) and the presence of fissured tongue, a manifestation that occurs very often in concomitance with BMG...
September 2020: Case Reports in Dermatology
https://read.qxmd.com/read/32568824/syphilis-a-contemporary-clinicopathologic-assessment
#5
JOURNAL ARTICLE
Jerome B Taxy, Thomas Cibull
Syphilis is a sexually transmitted disease caused by the spirochetal bacterium Treponema pallidum that has been of public health concern for centuries. In the United States, it is currently a reportable disease and one which is recently generating increasing case numbers especially in at risk populations of immune deficiency and men who have sex with men. The present series examines biopsies from 13 patients collected over a 12-year period from a general hospital network in north suburban Cook County, Illinois...
September 2020: American Journal of Surgical Pathology
https://read.qxmd.com/read/32433498/pivotal-role-of-cd103-in-the-development-of-psoriasiform-dermatitis
#6
JOURNAL ARTICLE
Takehito Fukui, Tomohiro Fukaya, Tomofumi Uto, Hideaki Takagi, Junta Nasu, Noriaki Miyanaga, Yotaro Nishikawa, Haruhiko Koseki, Narantsog Choijookhuu, Yoshitaka Hishikawa, Yoshihiro Yamashita, Katsuaki Sato
The integrin αE known as CD103 binds integrin β7 to form the complete heterodimeric integrin molecule αEβ7. CD103 is mainly expressed by lymphocytes within epithelial tissues of intestine, lung, and skin as well as subsets of mucosal and dermal conventional dendritic cells (cDCs). CD103 has been originally implicated in the attachment of lymphocytes to epithelium in the gut and skin through the interaction with E-cadherin expressed on intestinal epithelial cells, keratinocytes, and Langerhans cells (LCs)...
May 20, 2020: Scientific Reports
https://read.qxmd.com/read/31989432/palatal-erythema-with-histological-psoriasiform-pattern-an-enigmatic-oral-finding-shared-by-a-range-of-conditions
#7
JOURNAL ARTICLE
Ayelet Zlotogorski Hurvitz, Yehuda Zadik, Leon Gillman, Ori Platner, Tali Shani, Yuli Goldman, Gavriel Chaushu, Ilana Kaplan, Aviv Barzilai, Nadav Astman, Shoshana Reiter, Marilena Vered
Long standing, asymptomatic, well-demarcated erythema of the hard palate with a histopathological psoriasiform pattern comprises a challenging diagnosis. We present a series of patients with such clinical and histological findings and discuss the possible diagnoses. We collected all patients with palatal erythematous lesions that had well-documented clinical examination. Excluded were patients with definitive diagnosis of oral infections (e.g. candidiasis), neoplastic/pre-neoplastic lesions, auto-immune diseases, reactive lesions, blood disorders and vascular malformations...
January 27, 2020: Head and Neck Pathology
https://read.qxmd.com/read/31867207/laryngeal-mucous-membrane-plasmacytosis-with-15-year-follow-up-case-report-and-literature-review
#8
Vladislav V Makarenko, Alec E Vaezi, Doreen B Brettler, Lloyd Hutchinson, Bruce A Woda, Benjamin J Chen
Mucous membrane plasmacytosis (MMP) is an uncommon variant of mucositis represented by a polyclonal plasma cell infiltration of mucosal tissue. Various clinical presentations in the upper airway have been reported ranging from erythematous mucosa to fungating masses. Histologic features include mucosal epithelial hyperplasia or psoriasiform changes with a dense submucosal infiltrate of polytypic plasma cells. Molecular studies for immunoglobulin gene rearrangement should be performed in all cases of MMP to rule out clonal neoplastic expansion of plasma cells...
2020: Leukemia Research Reports
https://read.qxmd.com/read/29527027/palmoplantar-lesions-of-lichen-planus
#9
JOURNAL ARTICLE
Surabhi Sinha, Rashmi Sarkar, Vijay Kumar Garg
INTRODUCTION: Palmoplantar lesions of lichen planus (LP) are uncommon and may not always have classical clinical features of LP. A variety of morphological types has been described in literature. AIM AND OBJECTIVES: The aim was to study and classify the clinical variants into distinct easily recognisable categories for quick recognition and early treatment initiation. METHODS: All patients diagnosed with LP over a period of 5 years were evaluated for palmoplantar lesions in our hospital...
January 2018: Indian Journal of Dermatology
https://read.qxmd.com/read/26845824/oral-and-maxillofacial-pathology-case-of-month-keratitic-psoriasiform-mucositis
#10
JOURNAL ARTICLE
Laith Mahmood, Ashley N Neuman-Clark, Shawn Adibi, Afshan Kaviani, Jerry E Bouquot
No abstract text is available yet for this article.
November 2015: Texas Dental Journal
https://read.qxmd.com/read/25875052/occurrence-of-psoriasiform-eruption-during-nivolumab-therapy-for-primary-oral-mucosal-melanoma
#11
JOURNAL ARTICLE
Mikio Ohtsuka, Takako Miura, Tatsuhiko Mori, Masato Ishikawa, Toshiyuki Yamamoto
No abstract text is available yet for this article.
July 2015: JAMA Dermatology
https://read.qxmd.com/read/25033289/chronic-granulomatous-otitis-externa-as-an-initial-presentation-of-cutaneous-crohn-disease
#12
JOURNAL ARTICLE
Eileen M Raynor
IMPORTANCE: In the limited number of Crohn disease cases involving the head and neck, there is a predilection for mucosal surfaces and rare reports of involvement in the postauricular region. To our knowledge, in all previously reported cases involving the head and neck, the patients had a known diagnosis of Crohn disease. OBSERVATIONS: This case describes a 10-year-old boy with a history of psoriasis and psoriasiform dermatitis who presented with bilateral chronic granulomatous otitis externa, obliteration of the external auditory canal, and fissuring, resulting in separation of the lobule from the preauricular skin...
August 2014: JAMA Otolaryngology—Head & Neck Surgery
https://read.qxmd.com/read/23221488/acute-mucocutaneous-methotrexate-toxicity-associated-with-interface-dermatitis-and-numerous-eosinophils
#13
JOURNAL ARTICLE
Nkanyezi N Ferguson, Adam Asarch, Marta VanBeek, Brian L Swick
Acute mucocutaneous methotrexate toxicity is not classically associated with prominent tissue eosinophilia. We present a case of acute methotrexate toxicity associated with pancytopenia and mucocutaneous erosion with interface dermatitis and numerous eosinophils. A 79-year-old male, with a history of psoriasis vulgaris on methotrexate therapy, presented with blisters of the oral mucosa, groin, sacrum, and extremities after daily consumption of methotrexate. Examination revealed blisters and erosions localized to psoriatic plaques, the perineum, and the oral mucosa...
June 2013: American Journal of Dermatopathology
https://read.qxmd.com/read/23106553/dermatopathology-of-the-foreskin-an-institutional-experience-of-over-400-cases
#14
JOURNAL ARTICLE
Dava S West, John A Papalas, Maria A Selim, Robin T Vollmer
BACKGROUND: Diseases of the foreskin may manifest with an array of pathologic findings, including potentially under-recognized dermatologic conditions. Herein, we summarize an institutional experience in foreskin dermatopathology. METHODS: Diagnoses rendered on foreskin specimens between 1982 and April 2009 were obtained through a computer-based keyword search. Cases given normal, non-specific or descriptive diagnoses were reviewed by a dermatopathologist. RESULTS: Keyword search yielded 414 foreskin diagnoses...
January 2013: Journal of Cutaneous Pathology
https://read.qxmd.com/read/22612595/psoriasiform-eruption-and-oral-ulcerations-as-adverse-effects-of-topical-5-imiquimod-treatment-in-children-a-report-of-four-cases
#15
JOURNAL ARTICLE
Wallace A Smith, Dawn Siegel, Valerie B Lyon, Kristen E Holland
Imiquimod 5% cream is a topical immune-response modifier indicated in the treatment of multiple cutaneous conditions including actinic keratoses, superficial basal cell carcinoma, and condylomata acuminata. In children, it has been approved only for ages 12 and older in the treatment of external genital and perianal warts. It has also been used off label for a variety of pediatric skin disorders, including molluscum contagiosum (MC), trichoepitheliomas, verrucae plana, and verrucae vulgaris. Local and systemic adverse reactions have been reported, with the most frequently reported events being application site reactions including itching, burning, erythema, and erosion...
November 2013: Pediatric Dermatology
https://read.qxmd.com/read/21929814/oral-mucosal-lesions-in-skin-diseased-patients-attending-a-dermatologic-clinic-a-cross-sectional-study-in-sudan
#16
JOURNAL ARTICLE
Nada M Suliman, Anne N Astrøm, Raouf W Ali, Hussein Salman, Anne C Johannessen
BACKGROUND: So far there have been no studies focusing on the prevalence of a wide spectrum of oral mucosal lesions (OML) in patients with dermatologic diseases. This is noteworthy as skin lesions are strongly associated with oral lesions and could easily be neglected by dentists. This study aimed to estimate the frequency and socio-behavioural correlates of OML in skin diseased patients attending outpatient's facility of Khartoum Teaching Hospital - Dermatology Clinic, Sudan. METHODS: A cross-sectional hospital-based study was conducted in Khartoum from October 2008 to January 2009...
September 19, 2011: BMC Oral Health
https://read.qxmd.com/read/17243950/sensitization-to-acrylates-is-a-common-adverse-reaction-to-artificial-fingernails
#17
JOURNAL ARTICLE
A Lazarov
BACKGROUND: Although precise figures for adverse reactions to nail-care products are not available, it is thought that one of the main risks from artificial nails (ANs) is contact allergy. OBJECTIVE: To evaluate the role of allergic contact dermatitis (ACD) as a cause of adverse reactions related to the use of ANs. METHOD: A 4-year retrospective study of patients with suspected ACD from ANs was conducted. Patients tested with the methacrylate artificial nail (MAAN) series were evaluated clinically and patch test results were analysed...
February 2007: Journal of the European Academy of Dermatology and Venereology: JEADV
https://read.qxmd.com/read/16325063/syphilis-uncommon-presentations-in-adults
#18
REVIEW
Lyubomir A Dourmishev, Assen L Dourmishev
The clinical manifestations of syphilis are variable in appearance and have been described for centuries. The disease has been arbitrarily divided mainly into three stages. Uncommon presentations of syphilis in adults include (a) primary syphilis-atypical forms of chancre vary in size, shape, morphology, and color. Small ulcus durum is single or multiple, grouped, or herpetiform. Giant necrotic and phagedenic chancres are resolved with scar formation. In intratriginous areas, ulcus durum is rhagadiform, linear, "rocket type," or bilateral...
November 2005: Clinics in Dermatology
https://read.qxmd.com/read/16086741/hereditary-mucoepithelial-dysplasia-clinical-ultrastructural-and-genetic-study-of-eight-patients-and-literature-review
#19
REVIEW
F Boralevi, M Haftek, P Vabres, S Lepreux, C Goizet, C Leaute-Labreze, A Taieb
BACKGROUND: Hereditary mucoepithelial dysplasia is a dominantly inherited disease, mainly characterized by chronic mucosal lesions associated with keratitis, non-scarring alopecia, keratosis pilaris and perineal intertrigo. Since the original report by Witkop, this condition has been considered to be a disorder of desmosome/gap junction formation, but there has been no ex vivo investigation of these components using genetic and immunolabelling techniques. OBJECTIVES: To perform light and immunoelectron microscopic studies, and partial genetic analysis on five patients in a family and three sporadic cases and to point out similarities of this rare disorder with chronic mucocutaneous candidiasis and other follicular keratosis syndromes, i...
August 2005: British Journal of Dermatology
https://read.qxmd.com/read/15670173/complicated-lichenoid-drug-eruption
#20
JOURNAL ARTICLE
Katherine Armour, Patricia Lowe
We report a case of severe lichenoid drug eruption with multiple possible causative agents. A hepatitis C-positive male presented with a short history of painful erosions of the vermilion, lichenoid lesions on the buccal mucosa and glans penis, and erosions and lichenification of the scrotum. In addition, he had a pruritic polymorphic eruption over the scalp, trunk and limbs, comprising psoriasiform and eczematous lesions. He had received combination therapy of pegylated interferon-alpha-2a and ribavirin, along with granulocyte colony-stimulating factor for interferon-induced leucopenia, and propranolol for portal hypertension...
February 2005: Australasian Journal of Dermatology
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