Jing Ye, Xiaoqian Li, Zhihao Pan, Zhuoya Wu, Yanyun Zhu, Wei Zhang, Juntai Lu, Shuangshuang Xu, Ping Qin, Ya Liu, Yunsheng Li, Yinghui Ling, Fugui Fang
The study aimed to investigate the effect of Grid1, encoding the glutamate ionotropic receptor delta type subunit 1(GluD1), on puberty onset in female rats. Grid1 mRNA and protein expression was detected in the hypothalamus of female rats at prepuberty and puberty. Additionally, the expression of Grid1 was suppressed in primary hypothalamus cells and prepubertal rat. Finally, investigated the effect of Grid1 knockdown on puberty onset and reproductive performance. The levels of Grid1 mRNA in the hypothalamus, the fluorescence intensity in the arcuate nucleus and paraventricular nucleus of the prepubertal rats was significantly lower than pubertal...
March 14, 2024: Journal of Veterinary Medical Science