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Jessica L Chitty, Mark S Butler, Azzah Suboh, David J Edwards, Matthew A Cooper, James A Fraser, Avril A B Robertson
Resistance to antimicrobials is a growing problem in both developed and developing countries. In nations where AIDS is most prevalent, the human fungal pathogen Cryptococcus neoformans is a significant contributor to mortality, and its growing resistance to current antifungals is an ever-expanding threat. We investigated octapeptin C4, from the cationic cyclic lipopeptide class of antimicrobials, as a potential new antifungal. Octapeptin C4 was a potent, selective inhibitor of this fungal pathogen with an MIC of 1...
February 2018: Antimicrobial Agents and Chemotherapy
Bakar Fakih, Azzah A S Nofly, Ali O Ali, Abdallah Mkopi, Ali Hassan, Ali M Ali, Kate Ramsey, Theopista John Kabuteni, Godfrey Mbaruku, Mwifadhi Mrisho
BACKGROUND: It is estimated that 287,000 women worldwide die annually from pregnancy and childbirth-related conditions, and 6.9 million under-five children die each year, of which about 3 million are newborns. Most of these deaths occur in sub-Saharan Africa. The maternal health situation in Tanzania mainland and Zanzibar is similar to other sub-Saharan countries. This study assessed the availability, accessibility and quality of emergency obstetric care services and essential resources available for maternal and child health services in Zanzibar...
June 3, 2016: BMC Pregnancy and Childbirth
Ghaleb Elyamany, Azzah Alzahrani, Huda Elfaraidi, Omar Alsuhaibani, Nada Othman, Eman Al Mussaed, Fahad Alabbas
Hemophagocytic lymphohistiocytosis (HLH) is a rare but potentially fatal disease that commonly appears in infancy, although it has been reported in adults. Chemoimmunotherapy-based treatments have improved the survival of patients with HLH; however, overall survival is still poor. We retrospectively analyzed the data of 12 HLH patients who were admitted between 2005 and 2014. All patients were Saudi Arabia in origin with a female predominance (75%) and a median age of onset of 9.5 months. The consanguinity rates were significantly high (75%) with a positive family history in 41% of cases...
2016: Clinical Medicine Insights. Pediatrics
Mohamed H Al-Hamed, Fatma AlBatniji, Ghadah A AlDakheel, Huda El-Faraidi, Azzah Al-Zahrani, Fahed Al-Abbass, Faiqa Imtiaz
Congenital protein C deficiency is an inherited coagulation disorder associated with an elevated risk of venous thromboembolism. A Saudi Arabian male from a consanguineous family was admitted to neonatal intensive care unit in his first days of life because of transient tachypnea and hematuria. Laboratory investigations determined low platelet and protein C deficiency. Direct sequencing of PROC gene and RNA analysis were performed. Analysis of factor V Leiden (G1691A) and factor II (G20210A) mutations was also done...
July 2016: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
Ahmad Aidil Arafat Dzulkarnain, Wan Mahirah Wan Mhd Pandi, Sarah Rahmat, Nur 'Azzah Zakaria
OBJECTIVE: To systematically review the relevant peer-review literature investigating the outcome of simulated learning environment (SLE) training in audiology education. DESIGN: A systematic review research design. STUDY SAMPLE: Fifteen databases were searched with four studies meeting the inclusion criteria. RESULTS: Three of the four studies revealed positive findings for the use of an SLE (that is, the SLE group showed a higher post-training score compared to the traditional training group or a significantly higher post-training score than the non-training groups)...
2015: International Journal of Audiology
Tetsuya Kida, Hiromasa Furuso, Kota Kumamoto, Azzah Dyah Pramata, Masayoshi Yuasa, Kengo Shimanoe
Recently, the process by which energy is transferred from photoexcited semiconductor nanocrystals, called quantum dots (QDs), to other semiconductors has attracted much attention and has potential application in solar energy conversion (i.e., QD-sensitized solar cells). Sensitization of wide band gap polyoxometalates (POMs) to visible light by using CuInS2 QDs dispersed in an organic solution is demonstrated herein. Photoluminescence quenching and lifetime studies revealed efficient electron transfer from the CuInS2 QDs to POMs, such as SiW12 O40 and W10 O32 , that were hybridized with a cationic surfactant...
May 11, 2015: Chemistry: a European Journal
Azzah M Bannunah, Driton Vllasaliu, Jennie Lord, Snjezana Stolnik
This study investigated the effect of nanoparticle size (50 and 100 nm) and surface charge on their interaction with Caco-2 monolayers as a model of the intestinal epithelium, including cell internalization pathways and the level of transepithelial transport. Initially, toxicity assays showed that cell viability and cell membrane integrity were dependent on the surface charge and applied mass, number, and total surface area of nanoparticles, as tested in two epithelial cell lines, colon carcinoma Caco-2 and airway Calu-3...
December 1, 2014: Molecular Pharmaceutics
Stine Lund, Vibeke Rasch, Maryam Hemed, Ida Marie Boas, Azzah Said, Khadija Said, Mkoko Hassan Makundu, Birgitte Bruun Nielsen
BACKGROUND: Mobile phones are increasingly used in health systems in developing countries and innovative technical solutions have great potential to overcome barriers of access to reproductive and child health care. However, despite widespread support for the use of mobile health technologies, evidence for its role in health care is sparse. OBJECTIVE: We aimed to evaluate the association between a mobile phone intervention and perinatal mortality in a resource-limited setting...
March 26, 2014: JMIR MHealth and UHealth
Stine Lund, Birgitte B Nielsen, Maryam Hemed, Ida M Boas, Azzah Said, Khadija Said, Mkoko H Makungu, Vibeke Rasch
BACKGROUND: Applying mobile phones in healthcare is increasingly prioritized to strengthen healthcare systems. Antenatal care has the potential to reduce maternal morbidity and improve newborns' survival but this benefit may not be realized in sub-Saharan Africa where the attendance and quality of care is declining. We evaluated the association between a mobile phone intervention and antenatal care in a resource-limited setting. We aimed to assess antenatal care in a comprehensive way taking into consideration utilisation of antenatal care as well as content and timing of interventions during pregnancy...
January 17, 2014: BMC Pregnancy and Childbirth
Mohamad H Qari, Yasser Wali, Muneer H Albagshi, Mohammad Alshahrani, Azzah Alzahrani, Ibrahim A Alhijji, Abdulkareem Almomen, Abdullah Aljefri, Hussain H Al Saeed, Shaker Abdullah, Ahmad Al Rustumani, Khoutir Mahour, Shaker A Mousa
Thalassemia syndrome has diverse clinical presentations and a global spread that has far exceeded the classical Mediterranean basin where the mutations arose. The mutations that give rise to either alpha or beta thalassemia are numerous, resulting in a wide spectrum of clinical severity ranging from carrier state to life-threatening, inherited hemolytic anemia that requires regular blood transfusion. Beta thalassemia major constitutes a remarkable challenge to health care providers. The complications arising due to the anemia, transfusional iron overload, as well as other therapy-related complications add to the complexity of this condition...
September 17, 2013: Orphanet Journal of Rare Diseases
Hind M Alkatan, Azzah Maktabi
Retinoblastoma is one of the most important childhood tumors with genetic implications and necessity for family counseling and long term follow up. We are presenting a 22 year-old Saudi male with history of bilateral retinoblastoma, who was initially treated by enucleation of his left eye. The histopathology showed a moderately differentiated tumor with vitreous seeding and he received chemotherapy in addition to radiotherapy to his right eye. He presented 20 years later with a right orbital tumor, frozen globe and proptosis...
January 2010: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
Jihan Turkistani, Azzah Hanno
One of the commonly encountered dental emergencies is dentoalveolar traumatic injuries (DTIs). Unfortunately, DTIs result in fractured, displaced, or lost anterior teeth and this could have significant negative functional, esthetic, speech, and psychological effects on children thus affecting their quality of life. Although it is impossible to guarantee permanent retention of a traumatized tooth, patient age, severity of injury, and timely treatment and follow up of the tooth using recommended procedures can maximize the chances for success...
February 2011: Dental Traumatology: Official Publication of International Association for Dental Traumatology
Devorah C Goldman, Alexis S Bailey, Dana L Pfaffle, Azzah Al Masri, Jan L Christian, William H Fleming
Bone morphogenetic protein 4 (BMP4) is required for mesoderm commitment to the hematopoietic lineage during early embryogenesis. However, deletion of BMP4 is early embryonically lethal and its functional role in definitive hematopoiesis is unknown. Consequently, we used a BMP4 hypomorph to investigate the role of BMP4 in regulating hematopoietic stem cell (HSC) function and maintaining steady-state hematopoiesis in the adult. Reporter gene expression shows that Bmp4 is expressed in cells associated with the hematopoietic microenvironment including osteoblasts, endothelial cells, and megakaryocytes...
November 12, 2009: Blood
Azzah Al Masri, Sandra J Gendler
MUC1 is an integral membrane mucin glycoprotein that is normally expressed on the apical surface of most simple, secretory epithelia and hematopoietic cells. Overexpression of aberrantly glycosylated MUC1 is a hallmark of many carcinomas including 90% of breast carcinomas. MUC1 has been shown to bind to c-Src tyrosine kinase in vitro, whereby c-Src phosphorylates the MUC1 cytoplasmic domain at a YEKV motif. c-Src is an extensively studied nonreceptor tyrosine kinase implicated in mammary tumorigenesis. Previously, mouse mammary tumor virus-driven polyoma middle T-antigen (MMTV-PyV MT) transgenic mice crossed onto a Muc1 null background exhibited a significant delay in tumor progression...
September 1, 2005: Oncogene
Joyce A Schroeder, Azzah Al Masri, Melissa C Adriance, Jennifer C Tessier, Kari L Kotlarczyk, Melissa C Thompson, Sandra J Gendler
MUC1 is a transmembrane mucin that was initially cloned from malignant mammary epithelial cells as a tumor antigen. More than 90% of human breast carcinomas overexpress MUC1. Numerous studies have demonstrated an interaction between MUC1 and other oncogenic proteins such as beta-catenin, erbB receptors and c-Src, but a functional role for MUC1 in transformation has not been identified. We previously reported the development of transgenic mice that overexpress human MUC1 in the mouse mammary gland (MMTV-MUC1)...
July 29, 2004: Oncogene
Azzah S Jeddy, Brenda L Gleason
OBJECTIVE: To review data concerning combined aspirin/warfarin versus aspirin alone for secondary prevention after myocardial infarction (MI). DATA SOURCES: Literature was accessed through MEDLINE (1966-September 2002). Search terms included aspirin, warfarin, secondary prevention, and myocardial infarction. DATA SYNTHESIS: Despite use of low-dose aspirin after an MI, risk of subsequent death and ischemic events remains high, making strategies for secondary prevention imperative...
October 2003: Annals of Pharmacotherapy
Molly A Accola, Bing Huang, Azzah Al Masri, Mark A McNiven
Mx proteins are induced by type I interferon and inhibit a broad range of viruses by undefined mechanisms. They are included within the dynamin family of large GTPases, which are involved in vesicle trafficking and share common biophysical features. These properties include the propensity to self-assemble, an affinity for lipids, and the ability to tubulate membranes. In this report we establish that human MxA, despite sharing only 30% homology with conventional dynamin, possesses many of these properties. We demonstrate for the first time that MxA self-assembles into rings that tubulate lipids in vitro, and associates with a specific membrane compartment in cells, the smooth endoplasmic reticulum...
June 14, 2002: Journal of Biological Chemistry
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