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https://www.readbyqxmd.com/read/29655692/effects-of-xin-ji-er-kang-on-heart-failure-induced-by-myocardial-infarction-role-of-inflammation-oxidative-stress-and-endothelial-dysfunction
#1
Juan Hu, Pan Cheng, Guang-Yao Huang, Guo-Wei Cai, Feng-Zhen Lian, Xiao-Yun Wang, Shan Gao
BACKGROUND: Xin-Ji-Er-Kang (XJEK) is a Chinese herbal formula, which has been reported to exert effective protection on cardiovascular diseases like hypertension and myocarditis. PURPOSE: To elucidate the protective effects of XJEK on heart failure (HF) induced by myocardial infarction (MI) through the amelioration of inflammation, oxidative stress (OS) and endothelial dysfunction(ED). MATERIALS AND METHODS: Fifty-seven male KM mice were randomized into the following six groups (n = 9-10 for each): control group, model group, MI+XJEK low dose group(XJEKL) group, MI+XJEK middle dose group(XJEKM), MI+XJEK high dose group(XJEKH), and MI+fosinopril group (positive control group)...
March 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29652902/relations-between-right-ventricular-morphology-and-clinical-electrical-and-genetic-parameters-in-brugada-syndrome
#2
Belinda Gray, Ganesh Kumar Gnanappa, Richard D Bagnall, Giuseppe Femia, Laura Yeates, Jodie Ingles, Charlotte Burns, Rajesh Puranik, Stuart M Grieve, Christopher Semsarian, Raymond W Sy
BACKGROUND: Increasing evidence suggests the presence of structural changes affecting the right ventricular outflow tract (RVOT) in patients with Brugada Syndrome (BrS). The aim of this study was to characterise the RV morphology in BrS and explore associations between morphologic, clinical, electrical, and genetic parameters using non-invasive multimodality testing. METHODS: Consecutive BrS patients (recruited 2013-2015) underwent clinical assessment, dedicated RV imaging using cardiac magnetic resonance (CMR) imaging (unless contra-indicated), electrical assessment (electrocardiogram, Holter monitoring, signal-averaged ECG[SAECG]) and genotyping...
2018: PloS One
https://www.readbyqxmd.com/read/29645285/cardiovascular-safety-of-the-%C3%AE-3-adrenoceptor-agonist-mirabegron-and-the-antimuscarinic-agent-solifenacin-in-the-synergy-trial
#3
William B White, Christopher Chapple, Christian Gratzke, Sender Herschorn, Dudley Robinson, Jeffrey Frankel, Arwin Ridder, Matthias Stoelzel, Asha Paireddy, Robert van Maanen, Michael A Weber
There have been concerns that treatment of overactive bladder with β3 -adrenoceptor agonists may potentially have detrimental cardiovascular (CV) side effects. We evaluated the CV safety of mirabegron, a β3 -adrenoceptor agonist, alone and in combination therapy with the antimuscarinic agent solifenacin. The SYNERGY trial was a multinational, multicenter, randomized, double-blind, parallel-group, placebo and active-controlled phase 3 trial. Patients were randomized to receive solifenacin 5 mg + mirabegron 50 mg (combination 5 + 50 mg), solifenacin 5 mg + mirabegron 25 mg (combination 5 + 25 mg), solifenacin 5 mg monotherapy, mirabegron 25 mg monotherapy, mirabegron 50 mg monotherapy, or placebo for a 12-week double-blind treatment period...
April 12, 2018: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29643700/evaluation-of-the-accuracy-of-ecg-captured-by-cardiochip-through-comparison-of-lead-i-recording-to-a-standard-12-lead-ecg-recording-device
#4
Chi-In Lo, Sheng-Shiung Chang, Jui-Peng Tsai, Jen-Yuan Kuo, Ying-Ju Chen, Ming-Yuan Huang, Chao-Hsiung Lee, Kuo-Tzu Sung, Chung-Lieh Hung, Charles Jia-Yin Hou, Edward Lai, Hung-I Yeh, Wen-Ling Chang, Wen-Han Chang
Background: Remote cardiac rhythm monitoring and recording, using hand-carried electrocardiogram (ECG) device had been widely used in telemedicine. The feasibility and accuracy analysis on the data recorded by a new miniature ECG system-on-chip (SoC) system has not been explored before. Methods: This study evaluated the accuracy of the ECG recordings captured by CardioChip - a single-channeled, low-powered, miniature ECG SoC designed for mobile applications; comparing against Philips Pagewriter Trim III - a Food and Drug Administration certified, widely-used standard 12-lead ECG recording device, within Mackay Memorial Hospital in Taiwan...
March 2018: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/29629998/predictive-and-prognostic-value-of-left-ventricular-mechanical-dyssynchrony-assessed-by-myocardial-perfusion-single-photon-emission-computed-tomography-in-asymptomatic-patients-under-hemodialysis
#5
Federico Caobelli, Cristina E Popescu, Riccardo Laudicella, Alessio Comis, Salvatore A Pignata, Roberto Sara, Claudio Rossetti
BACKGROUND: Patients under hemodialysis (HD) have an increased risk of major adverse cardiac events (MACEs). In these patients, myocardial perfusion scintigraphy (MPS) provides useful prognostic information. Left ventricular mechanical dyssynchrony (LVD) has been proven to predict all-cause death in patients under HD. It remains unclear, whether the same prognostic value pertains also to the prediction of MACEs. PATIENTS AND METHODS: Ninety patients under HD (duration range: 2-216 months) with neither history nor symptoms of coronary artery disease at the time of MPS were retrospectively evaluated...
May 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29627347/trpa1-mediates-the-cardiac-effects-of-acrolein-through-parasympathetic-dominance-but-also-sympathetic-modulation-in-mice
#6
Nicole Kurhanewicz, Allen Ledbetter, Aimen Farraj, Mehdi Hazari
Numerous studies have demonstrated that short-term air pollution exposure causes cardiac autonomic imbalance as measured by heart rate variability (HRV). We previously showed that a single exposure to acrolein, a ubiquitous gaseous component of air pollution, not only causes autonomic imbalance, but also increases arrhythmia through transient receptor potential A1 (TRPA1) cation channels. Thus, the goal of this study was to characterize acrolein-induced autonomic changes in both normal and TRPA1-knockout mice (KO)...
April 5, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29626346/propofol-for-implantable-cardioverter-defibrillator-implantation-in-patients-with-brugada-syndrome
#7
Hye-Mee Kw On, Sung-Hoon Kim, Se-Ung Pa Rk, Jin-Ho Rh Im, Hee-Su N Park, Wook-Jong Kim, Gi-Byou Ng Nam
AIMS: Avoiding propofol in patients with Brugada syndrome has been suggested because of the theoretical risk of provoking ventricular arrhythmias, although propofol may be selected for conscious sedation during electrophysiological procedures in catheterization laboratories. This study aimed to document peri-procedural electrocardiographic changes and adverse events in patients with Brugada syndrome undergoing implantable cardioverter defibrillator (ICD) implantation using propofol sedation...
April 6, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29623770/atypical-presentation-of-acute-coronary-syndrome-acs-a-case-report
#8
Axel Van Damme, Philippe Vanderheeren, Tine De Backer, Françine Desimpel
Case A 45-year-old man presented at the emergency department (ED) with stomach pain since eight days. The patient was not worried about his symptoms and requested only pain relief. The emergency physician requested a consult of the gastroenterologist. Clinical examination was unremarkable. However, 12-lead ECG and ischemic markers were suggestive of acute coronary syndrome (ACS) which led to admission at the cardiology department. Despite delayed presentation, the patient was still referred for urgent coronary angiogram after receiving heparin, ticagrelor and acetylsalicylic acid because of persistent pain...
April 6, 2018: Acta Clinica Belgica
https://www.readbyqxmd.com/read/29623413/no-effect-of-season-on-the-electrocardiogram-of-long-eared-bats-nyctophilus-gouldi-during-torpor
#9
Shannon E Currie
Heterothermic animals regularly undergo profound alterations of cardiac function associated with torpor. These animals have specialised tissues capable of withstanding fluctuations in body temperature > 30 °C without adverse effects. In particular, the hearts of heterotherms are able to resist fibrillation and discontinuity of the cardiac conduction system common in homeotherms during hypothermia. To investigate the patterns of cardiac conduction in small insectivorous bats which enter torpor year round, I simultaneously measured ECG and subcutaneous temperature (Tsub ) of 21 Nyctophilus gouldi (11 g) during torpor at a range of ambient temperatures (Ta 1-28 °C)...
April 5, 2018: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/29622996/clinical-profile-management-and-outcome-of-pulmonary-embolism-in-shahid-gangalal-national-heart-centre-kathmandu-nepal
#10
Chandra Mani Adhikari, K C Bishal, Sobita Khadka
Background and aims: Pulmonary embolism (PE) is associated with a significant mortality and morbidity. We aim to study clinical profile, management and outcome of PE at Shahid Gangalal National heart Centre, Kathmandu, Nepal. Methods: It was a retrprospective, single centre study, conducted from January 2015 to December 2016. Haemodynamics was used for risk Simplified, PESI score, predisposing factors, symptoms, clinical features at the time of admission, ECG features, echocardiogram, treatment received and the outcome were reviewed...
March 2018: The Egyptian heart journal: (EHJ): official bulletin of the Egyptian Society of Cardiology
https://www.readbyqxmd.com/read/29622376/mahaim-fiber-mediated-tachycardia
#11
Gustavo Lima da Silva, Nuno Cortez-Dias, Ana Bernardes, João Sousa
We present the case of a previously healthy 42-year-old man who attended the emergency department due to a sudden onset of rapid and regular palpitations. The ECG showed 190 bpm, wide QRS with left bundle branch block tachycardia. He was started on amiodarone with progression to 230 bpm, wide QRS tachycardia with multiple morphologies, followed by spontaneous conversion to sinus rhythm, normal PR interval and rS pattern in LIII. The echocardiogram was negative for structural heart disease. The electrophysiological study demonstrated the presence of an accessory pathway with anterograde decremental conduction and no retrograde conduction...
April 2, 2018: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29621571/ecg-changes-during-resuscitation-of-patients-with-initial-pulseless-electrical-activity-are-associated-with-return-of-spontaneous-circulation
#12
Gunnar Waage Skjeflo, Trond Nordseth, Jan Pål Loennechen, Daniel Bergum, Eirik Skogvoll
BACKGROUND: Pulseless electrical activity (PEA) is a frequent initial rhythm in cardiac arrest, and ECG characteristics have been linked to prognosis. The aim of this study was to examine the development of ECG characteristics during advanced life support (ALS) and cardiopulmonary resuscitation (CPR) in initial PEA, and to assess any association with survival. METHODS: Patients with in-hospital cardiac arrest with initial PEA at St. Olav Hospital (Trondheim, Norway) over a three-year period were included...
April 2, 2018: Resuscitation
https://www.readbyqxmd.com/read/29609921/a-comparison-of-the-cardiovascular-effects-of-simulated-and-spontaneous-laughter
#13
Mikaela M Law, Elizabeth A Broadbent, John J Sollers
OBJECTIVES: Laughter has long been regarded as beneficial for health, but the mechanisms are not clearly understood. The current study aimed to compare the acute cardiovascular effects of spontaneous and simulated laughter. DESIGN: A mixed factorial experiment was performed to examine changes in cardiovascular variables in response to experimental tasks across conditions. INTERVENTIONS: A sample of 72 participants were randomised to one of three 6 min interventions...
April 2018: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/29608997/the-beneficial-effects-of-electroacupuncture-at-pc6-acupoints-neiguan-on-myocardial-ischemia-in-asic3-mice
#14
Ying-Wang, Wan-Shuang Zhao, Di Li, Ya-Han Xu, Meng-di Li, Jin Chen, Zhi-Jun Kou, Qi-Ge Wang, Yi-Guo Chen, Nsoa Dimitri Joseph
This study aims to investigate the possible mechanisms of electroacupuncture (EA) at PC6 to improve myocardial ischemia (MI) by regulating the cardiac transient outward potassium current channel (Ito). According to the random number table, the mice were divided into 6 groups of 6 mice each: control group, MI group, PC6, LU7 (Lieque-point), ST36 (Zusanli-point), and nonacupoint group. Mice in the control group were injected with saline (20mg/kg, 24 hours interval), and the other ASIC3 -/- mice were injected subcutaneously twice with isoproterenol (ISO) (20mg/kg, 24 hours interval)...
March 30, 2018: Journal of Acupuncture and Meridian Studies
https://www.readbyqxmd.com/read/29605703/variability-in-the-time-to-initiation-of-cpr-in-continuously-monitored-pediatric-icus
#15
M Olson, E Helfenbein, L Su, M Berg, L Knight, L Troy, L Sacks, D Sakai, F Su
AIM: To study the influence of patient characteristics and unit ergonomics and human factors on the time to initiation of CPR. METHODS: A single center study of children, 0 to 21 years old, admitted to an ICU who experienced cardiopulmonary arrest (CPA) requiring >1 minute of chest compressions. Time of CPA was determined by analysis of continuous ECG, plethysmography, arterial blood pressure, and end-tidal CO2 (EtCO2 ) waveforms. Initiation of CPR was identified by the onset of cyclic artifact in the ECG waveform...
March 29, 2018: Resuscitation
https://www.readbyqxmd.com/read/29604089/electrocardiographic-left-ventricular-hypertrophy-predicts-recurrence-of-atrial-arrhythmias-after-catheter-ablation-of-paroxysmal-atrial-fibrillation
#16
Song-Nan Li, Lu Wang, Jian-Zeng Dong, Rong-Hui Yu, De-Yong Long, Ri-Bo Tang, Cai-Hua Sang, Chen-Xi Jiang, Nian Liu, Rong Bai, Xin Du, Chang-Sheng Ma
AIMS: Left ventricular hypertrophy (LVH) is an independent predictor of new-onset atrial fibrillation. Whether LVH can predict the recurrence of arrhythmia after radiofrequency catheter ablation (RFCA) in patients with paroxysmal atrial fibrillation (PAF) remains unclear. METHODS: A total of 436 patients with PAF undergoing first RFCA were consecutively enrolled and clustered into 2 groups based on electrocardiogram (ECG) findings: non ECG LVH (218 patients), ECG LVH (218 patients)...
March 31, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29603015/effect-of-ulixertinib-a-novel-erk1-2-inhibitor-on-the-qt-qtc-interval-in-patients-with-advanced-solid-tumor-malignancies
#17
Boaz Mendzelevski, Georg Ferber, Filip Janku, Bob T Li, Ryan J Sullivan, Dean Welsch, Wei Chi, Jeanne Jackson, Onglee Weng, Philip T Sager
PURPOSE: The aim of this analysis was to investigate the potential for ulixertinib (BVD-523) to prolong cardiac repolarization. The mean prolongation of the corrected QT (QTc) interval was predicted at the mean maximum drug concentrations of the recommended phase 2 dose (RP2D; 600 mg BID) and of higher concentrations. In addition, the effect of ulixertinib on other quantitative ECG parameters was assessed. METHODS: In a two-part, phase 1, open-label study in adults with advanced solid tumors, 105 patients [24 in Part 1 (dose escalation) and 81 in Part 2 (cohort expansion)] were included in a QT prolongation analysis...
March 30, 2018: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29599341/radiotherapy-induced-early-ecg-changes-and-their-comparison-with-echocardiography-in-patients-with-early-stage-breast-cancer
#18
Suvi Sirkku Tuohinen, Konsta Keski-Pukkila, Tanja Skyttä, Heini Huhtala, Vesa Virtanen, Pirkko-Liisa Kellokumpu-Lehtinen, Pekka Raatikainen, Kjell Nikus
BACKGROUND: Early electrocardiogram (ECG) changes after breast cancer radiotherapy (RT) have been reported, but their characteristics and associated factors are largely unknown. This study aimed to explore early RT-induced ECG changes and to compare them with echocardiography changes. MATERIALS AND METHODS: Sixty eligible patients with chemotherapy-naïve left-sided and 20 with right-sided breast cancer were evaluated with echocardiography, blood samples and ECG before and after RT...
April 2018: Anticancer Research
https://www.readbyqxmd.com/read/29598986/rhythmical-massage-improves-autonomic-nervous-system-function-a-single-blind-randomised-controlled-trial
#19
Georg Seifert, Jenny-Lena Kanitz, Carolina Rihs, Ingrid Krause, Katharina Witt, Andreas Voss
BACKGROUND: Rhythmical massage therapy (RMT) is a massage technique used in anthroposophic medicine. OBJECTIVE: The authors aimed to investigate the physiological action of RMT on the cardiovascular system by analysing heart rate variability (HRV). DESIGN, SETTING, PARTICIPANTS AND INTERVENTION: This study was a randomised, controlled and single-blinded trial, involving 44 healthy women (mean age: (26.20 ± 4.71) years). The subjects were randomised to one of three arms: RMT with aromatic oil (RA), RMT without aromatic oil (RM) or standardised sham massage (SM)...
March 6, 2018: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29593797/factors-influencing-p-terminal-force-in-lead-v1-of-the-ecg-in-hemodialysis-patients
#20
Andrzej Jaroszyński, Anna Jaroszyńska, Wojciech Dąbrowski, Tomasz Zaborowski, Andrzej Stepulak, Marek Iłżecki, Tomasz Zubilewicz
Introduction: Atrial fibrillation (AF) is a highly prevalent arrhythmia in hemodialysis (HD) patients, and an HD session may be a trigger for AF episodes. An abnormal P-terminal force in lead V1 (PTFV1) may predict new-onset AF in HD patients. The aim of the study was to assess the influence of the HD process on PTFV1 and to evaluate possible factors influencing PTFV1 in a group of selected HD patients. Material and methods: One hundred and fifty-three selected HD patients entered the study...
March 2018: Archives of Medical Science: AMS
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