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https://www.readbyqxmd.com/read/30221717/protective-effect-of-berberine-on-aconite%C3%A2-induced-myocardial-injury-and-the-associated-mechanisms
#1
Xueyan Chen, Huicai Guo, Qing Li, Yu Zhang, Huanlong Liu, Xiaofei Zhang, Kerang Xie, Zhongning Zhu, Qingfeng Miao, Suwen Su
Aconitum plants, which have analgesic, diuretic and anti‑inflammatory effects, have been widely used to treat various types of disease. However, the apparent toxicity of Aconitum‑derived agents, particularly in the cardiovascular system, has largely limited their clinical use. Thus, the present study investigated whether berberine (Ber), an isoquinoline alkaloid, may reduce myocardial injury induced by aconitine (AC) in rats and the underlying mechanisms. Rats (n=40) were randomly divided into four groups: Control, Chuan‑wu and Chuan‑wu + Ber (8 and 16 mg/kg doses)...
September 12, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/30217478/efficacy-of-atropine-sulfate-obidoxime-chloride-co-formulation-against-sarin-exposure-in-guinea-pigs
#2
Marloes Ja Joosen, Steven D Klaassen, Elwin Verheij, Tomas van Groningen, Alex S Cornelissen, Mario H Skiadopoulos, Laura Cochrane, Jeff D Shearer
The efficacy and pharmacokinetics of the aqueous co-formulation contents of the TROBIGARD™ (atropine sulfate, obidoxime chloride) auto-injector were evaluated in a sarin exposed guinea pig model. Two subcutaneous (sc) sarin challenge doses were evaluated in guinea pigs instrumented with brain and heart electrodes for electroencephalogram (EEG) and electrocardiogram (ECG). Sarin challenge doses were chosen to reflect exposure subclasses with sublethal (moderate to severe clinical signs) and lethal consequences...
September 11, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/30214268/received-care-compared-to-adp-guided-care-of-patients-admitted-to-hospital-with-chest-pain-of-possible-cardiac-origin
#3
Michael Perera, Leena Aggarwal, Ian A Scott, Bentley Logan
Purpose: To assess the extent to which accelerated diagnostic protocols (ADPs), compared to traditional care, identify patients presenting to emergency departments (EDs) with chest pain who are at low cardiac risk and eligible for early ED discharge. Patients and methods: Retrospective study of 290 patients admitted to hospital for further evaluation of chest pain following negative ED workup (no acute ischemic electrocardiogram [ECG] changes or elevation of initial serum troponin assay)...
2018: International Journal of General Medicine
https://www.readbyqxmd.com/read/30196932/usefulness-of-serial-12-lead-electrocardiograms-in-predicting-30-day-outcomes-in-patients-with-undifferentiated-chest-pain-the-asap-cath-study
#4
Robert F Riley, Chadwick D Miller, Gregory B Russell, Elsayed Z Soliman, Brian C Hiestand, David M Herrington, Simon A Mahler
An initial electrocardiogram (ECG) and serial troponin measurements are both independently and incrementally predictive of acute coronary syndrome in patients presenting with undifferentiated chest pain in the Emergency Department (ED). However, it is unclear if serial (ECGs) add significant to the contemporary diagnostic evaluation of this patient group. The ASAP CATH study was a single center, prospective study that enrolled patients presenting to an ED with undifferentiated chest pain. In addition to standard clinical evaluation, serial ECGs were performed at 90-minute intervals to evaluate whether serial changes suggestive of ischemia developed (Q waves, ST elevation or depression, or T-wave inversion)...
August 1, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/30190759/levels-of-serum-thyroxine-triidothyronine-and-thyrotropin-in-patients-with-acute-myocardial-infarction
#5
Rukhsana Gulzar, Mulazim Hussain Bukhari, Rehma Dar, Hira Sajjad
Objective: To determine the levels of serum thyroxine (T3, T4), triiodothyronine and thyrotropin in patients with acute myocardial infarction (AMI). Methods: It was an observational prospective study and 60 patients (both males and females) of AMI, (diagnosed by ECG & cardiac enzymes.) were included. Serum thyroid stimulating hormone (TSH), Free T3 and Free T4 were measured and relevant data was entered into a predesigned proforma. Results: FT3 levels were below the reference range in 56...
July 2018: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/30190643/assessment-of-right-ventricular-function-by-echocardiography-in-patients-with-chronic-heart-failure
#6
Viola William, Wael El Kilany
Background: The main focus of most of the studies in heart failure (HF) is the assessment of the left ventricular functions, while the right ventricle was much less studied. Much of this neglect is due to the complexity of anatomy and physiology of the right ventricle which are considered challenges during assessment of RV. Objective: [1] To review the alterations of right ventricular dimensions & function associated with chronic heart failure. [2] To predict the prevalence of right ventricular systolic dysfunction in patients with chronic heart failure, based on echocardiographic parameters...
September 2018: The Egyptian heart journal: (EHJ): official bulletin of the Egyptian Society of Cardiology
https://www.readbyqxmd.com/read/30188809/a-wearable-multi-modal-bio-sensing-system-towards-real-world-applications
#7
Siddharth Siddharth, Aashish Patel, Tzyy-Ping Jung, Terry Sejnowski
Multi-modal bio-sensing has recently been used as effective research tools in affective computing, autism, clinical disorders, and virtual reality among other areas. However, none of the existing bio-sensing systems support multi-modality in a wearable manner outside well-controlled laboratory environments with research-grade measurements. This work attempts to bridge this gap by developing a wearable multi-modal bio-sensing system capable of collecting, synchronizing, recording and transmitting data from multiple bio-sensors: PPG, EEG, eye-gaze headset, body motion capture, GSR, etc...
September 4, 2018: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/30183676/changes-in-f-wave-characteristics-during-cryoballoon-catheter-ablation
#8
Mikael Henriksson, Arcadi Garcıa-Alberola, Rebeca Goya, Alba Vadillo, Francisco-Manuel Melgarejo-Meseguer, Frida Sandberg, Leif Sörnmo
Changes in ECG-derived parameters are studied in atrial fibrillation (AF) patients undergoing cryoballoon catheter ablation. 
 Approach: Parameters characterizing f-wave frequency, morphology by phase dispersion, and amplitude are estimated using a model-based statistical approach. These parameters are studied before, during, and after ablation, as well as for AF type (paroxysmal/persistent). Seventy-seven (49/28 paroxysmal/persistent) AF patients undergoing de novo catheter ablation are included in the study, out of which 31 (16/15 paroxysmal/persistent) were in AF during the whole procedure...
September 5, 2018: Physiological Measurement
https://www.readbyqxmd.com/read/30181428/identifying-causal-relationships-between-eeg-activity-and-intracranial-pressure-changes-in-neurocritical-care-patients
#9
Ancor Sanz-Garcia, Miriam Perez-Romero, Jesus Pastor, Rafael G Sola, Lorena Vega-Zelaya, Fernando Monasterio, Carmen Torrecilla, Gema Vega, Paloma Pulido, Guillermo J Ortega
To exploring and assessing the relationship between the electroencephalography (EEG) activity with the intracranial pressure (ICP) in patients suffering from Traumatic Brain Injury (TBI) and Subarachnoid Hemorrhage (SAH) during their stay at the Intensive Care Unit (ICU)
 Methods: We performed an observational prospective cohort study of adult patients suffered from TBI or SAH. Continuous EEG-ECG was performed during ICP monitoring. In every patient, derived variables from the EEG were calculated and the Granger Causality (GC) methodology was employed to assess whether, and in which direction, any relationship between EEG and ICP exists...
September 5, 2018: Journal of Neural Engineering
https://www.readbyqxmd.com/read/30178333/impact-of-changes-in-systemic-physiology-on-fnirs-nirs-signals-analysis-based-on-oblique-subspace-projections-decomposition
#10
Nassim Nasseri, Alexander Caicedo, Felix Scholkmann, Hamoon Zohdi, Ursula Wolf
Measurements of cerebral and muscle oxygenation (StO2 ) and perfusion ([tHb]) with functional near-infrared spectroscopy (fNIRS) and near infrared spectroscopy (NIRS), respectively, can be influenced by changes in systemic physiology. The aim of our study was to apply the oblique subspace projections signal decomposition (OSPSD) to find the contribution from systemic physiology, i.e. heart rate (HR), electrocardiography (ECG)-derived respiration (EDR) and partial pressure of carbon dioxide (pCO2 ) to StO2 and [tHb] signals measured on the prefrontal cortex (PFC) and calf muscle...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/30177366/criteria-for-ecg-detection-of-acute-myocardial-ischemia-sensitivity-versus-specificity
#11
John J Wang, Olle Pahlm, James W Warren, John L Sapp, B Milan Horáček
BACKGROUND: Criteria for electrocardiographic detection of acute myocardial ischemia recommended by the Consensus Document of ESC/ACCF/AHA/WHF consist of two parts: The ST elevation myocardial infarction (STEMI) criteria based on ST elevation (ST↑) in 10 pairs of contiguous leads and the other on ST depression (ST↓) in the same 10 contiguous pairs. Our aim was to assess sensitivity (SE) and specificity (SP) of these criteria-and to seek their possible improvements-in three databases of 12‑lead ECGs...
August 13, 2018: Journal of Electrocardiology
https://www.readbyqxmd.com/read/30177330/long-term-favorable-cardiovascular-risk-profile-and-39-year-development-of-major-and-minor-electrocardiographic-abnormalities-the-chicago-healthy-aging-study-chas
#12
Thanh-Huyen T Vu, Martha L Daviglus, Kiang Liu, Norrina B Allen, Daniel B Garside, Donald M Lloyd-Jones
BACKGROUND: Data are limited on long-term associations of favorable cardiovascular risk profile (i.e., low-risk) and changes in risk profile with ECG abnormality development. METHODS: The Chicago Healthy Aging Study (CHAS) involved re-examination of 1395 participants, ages 65-84 years in 2007-10, free of baseline major ECG abnormalities or MI in 1967-1973. Stratified sampling method was used to recruit participants based on their baseline risk profile (low-risk and not low-risk)...
September 2018: Journal of Electrocardiology
https://www.readbyqxmd.com/read/30177325/ecg-parameters-to-predict-left-ventricular-electrical-delay
#13
Maria P Bonomini, Daniel F Ortega, Luis D Barja, Emilio Logarzo, Nicolás Mangani, Analía Paolucci
AIMS: Left ventricular (LV) dyssynchrony lengthens the left ventricular electrical delay (LVED), measured from QRS onset to the first peak of the LV electrogram. We constructed an ECG model to predict LVED noninvasively. METHODS: Intrapatient LVED was measured during a baseline vs nonselective His bundle pacing (nHBP) protocol. This setup provided paired synchronic/non-synchronic LVEDs, allowing intrapatient comparisons. Crosscorrelation of leads II and V6 was accomplished and extracted features together with age and gender fed a linear mixed effects model to predict LVED...
September 2018: Journal of Electrocardiology
https://www.readbyqxmd.com/read/30177313/impact-of-cardiac-rehabilitation-on-ventricular-repolarization-indexes-in-patients-with-rheumatid-arthritis
#14
Sinan Cerşit, Hülya Peynirci Cerşit
OBJECTIVE: Abnormalities in ventricular repolarization (VR) parameters have been associated with sudden cardiac death (SCD) in patients with rheumatoid arthritis (RA). The benefits of cardiac rehabilitation (CR) in patients with RA are well recognized. We aimed to assess its impact on VR indexes in patients with RA. METHODS: This study included 45 patients with RA (36 female, age 58 ± 5.5 years) and 50 age- and sex-matched otherwise healthy controls. Baseline electrocardiogram (ECG) recordings were used to compare VR parameters such as maximum and minimum QT intervals, and corrected, and dispersion (QTmax, QTmin, cQTmax, cQTmin, QTd, cQTd, respectively), JT and cJT intervals, Tp-e and cTp-e intervals, and Tp-e/QT and Tp-e/cQT ratios in patients with RA and healthy individuals...
September 2018: Journal of Electrocardiology
https://www.readbyqxmd.com/read/30174531/monotherapy-of-experimental-metabolic-syndrome-ii-study-of-cardiovascular-effects
#15
Vladimír Knezl, Ružena Sotníková, Zuzana Brnoliaková, Tatiana Stankovičová, Viktor Bauer, Štefan Bezek
Metabolic syndrome belongs to the most important risk factors of cardiovascular diseases. The aim of this study was to investigate changes in cardiovascular system induced by high cholesterol and high fat diet (HCHF) in HTG rats and their influence by a pyridoindole antioxidant - SMe1EC2 (S). The effects of S were compared with those of atorvastatin (A). Male HTG rats were fed HCHF (1% cholesterol + 7.5% lard) for 4 weeks. S and A were administered p.o., 50 mg/kg b.w. Following experimental groups were used: Wistar rats (W), hypertriglyceridemic rats (HTG), HTG rats fed HCHF (CHOL), HTG+S (S-HTG), CHOL+S (S-CHOL), and CHOL+A (A-CHOL)...
November 2017: Interdisciplinary Toxicology
https://www.readbyqxmd.com/read/30170934/osborn-wave-in-hypothermia-and-relation-to-mortality
#16
Oguz Eroglu, Sancar Serbest, Tarkan Kufeciler, Asim Kalkan
BACKGROUND & AIM: The aim of this study was to compare hypothermia patients with and without an Osborn wave (OW) in terms of physical examination findings, laboratory results, and clinical survival. METHODS: The study was carried out retrospectively on hypothermic patients. The hypothermic patients were divided into two groups. Group 1 comprised patients with OW on electrocardiogram (ECG), and Group 2 comprised patients without OW on ECG. The Mann-Whitney U test was used to compare the two groups, and the relationships between the variables and the presence of OW and mortality were analyzed with ANOVA...
August 19, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/30167000/st-segment-elevation-myocardial-infarction-with-normal-coronary-arteries
#17
Siddharthan Deepti, Raghav Bansal, Sandeep Singh
Case presentation: A middle-aged patient presented to the emergency department with intermittent chest pain of 4-hour duration. The patient had been recently diagnosed with metastatic adenocarcinoma of the colon and was receiving 5-fluorouracil (5-FU)-based chemotherapy at the time of presentation. The ECG at presentation showed 1 mm ST segment elevation in leads II, III and aVF, with reciprocal changes in leads aVL, V1 and V2 (figure 1A). Serum cardiac troponin I level was elevated at 0...
2018: Heart Asia
https://www.readbyqxmd.com/read/30165874/lying-position-classification-based-on-ecg-waveform-and-random-forest-during-sleep-in-healthy-people
#18
Hongze Pan, Zhi Xu, Hong Yan, Yue Gao, Zhanghuang Chen, Jinzhong Song, Yu Zhang
BACKGROUND: Several different lying positions, such as lying on the left side, supine, lying on the right side and prone position, existed when healthy people fell asleep. This article explored the influence of lying positions on the shape of ECG (electrocardiograph) waveform during sleep, and then lying position classification based on ECG waveform features and random forest was achieved. METHODS: By means of de-noising the overnight sleep ECG data from ISRUC website dataset, as well as extracting the waveform features, we calculated a total of 30 ECG waveform features, including 2 newly proposed features, S/R and ∠QSR...
August 30, 2018: Biomedical Engineering Online
https://www.readbyqxmd.com/read/30156246/comparative-analysis-of-fecal-phenolic-content-between-normal-and-obese-rats-after-oral-administration-of-tea-polyphenols
#19
Bo Chen, Jie Zhou, Qilu Meng, Yang Zhang, Shihua Zhang, Liang Zhang
Tea polyphenols (TP) have many health benefits, but most are metabolized into low molecular-weight phenolic acids after oral administration. In the present study, the absorption, metabolism, and excretion of catechins in rats fed a normal chow diet and in obese rats fed a high-fat and high-sugar (HFHS) diet were compared. After a ten-day oral administration of TP (500 mg per kg bw), the plasma levels of (-)-epigallocatechin gallate (EGCG) and (-)-gallocatechin gallate (GCG) in obese rats were significantly lower than those in the normal group...
August 29, 2018: Food & Function
https://www.readbyqxmd.com/read/30153992/qualitative-and-quantitative-evaluation-of-a-new-wearable-device-for-ecg-and-respiratory-holter-monitoring
#20
Antonio Sarmento, Carlo Vignati, Stefania Paolillo, Carolina Lombardi, Alessandra Scoccia, Flavia Nicoli, Massimo Mapelli, Alessandra Leonardi, Dario Ossola, Rudy Rigoni, Piergiuseppe Agostoni, Andrea Aliverti
BACKGROUND: Recent advances in wearable technology make continuous cardiorespiratory monitoring possible, with potential applications in assessment of cardiopulmonary patients, healthy subjects and athletes. The aim of the present study was to qualitatively and quantitatively evaluate a new wearable device (Learn Inspire Free Entertain = L.I.F.E.) by embedding in a compression shirt a 12‑lead ECG system and 5 respiratory sensors. METHODS: Thirty cardiorespiratory patients and ten healthy subjects were studied for 24 h during their usual life activities...
June 13, 2018: International Journal of Cardiology
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