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angiodysplasia

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https://www.readbyqxmd.com/read/28503284/arteriovenous-malformations-of-the-colon-a-report-of-two-cases-and-review-of-the-literature
#1
Ghodratollah Maddah, Abbas Abdollahi, Omid Rouhbakhshfar, Shirin Taraz Jamshidi, Masoumeh Hassanpour
BACKGROUND: Arteriovenous malformations are one of the most common vascular disorders of the colon. Vascular disorders present as painless, high-volume rectal bleeding. CASE PRESENTATION: This study elucidates two rare cases of vascular disorders that are diagnosed as angiodysplasia of the left colon and cavernous hemangioma of the colon and rectum. The chief complaint in two patients was rectorrhagia. The patients who were diagnosed of ulcerative colitis were treated with sulfadiazine and prednisone...
2017: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/28489838/-diagnostic-and-therapeutic-approach-to-small-bowel-disorders-through-capsule-endoscopy-and-double-balloon-endoscopy
#2
Federico De Simone, Pablo Machado, Edson Guzmán Calderon
Many small bowel disorders represent a great challenge for gastroenterologists and endoscopists due to the very low rates of success showed by the different agnosis techniques. The advent of the capsule endoscopy and double-balloon endoscopy has allowed a total, secure and efficient examination of the small bowel, which represents a real impact in diagnosis, treatment, and prognosis of our patients. The capsule endoscopy is a safe, minimally invasive procedure, which does not need sedation, does not cause pain, and allows the observation of the totality of the small bowel...
January 2017: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/28476066/angiodysplasia-in-von-willebrand-disease-understanding-the-clinical-and-basic-science
#3
Soundarya Selvam, Paula James
Severe and intractable gastrointestinal bleeding caused by angiodysplasia is a debilitating problem for up to 20% of patients with von Willebrand disease (VWD). Currently, the lack of an optimal treatment for this recurrent problem presents an ongoing challenge for many physicians in their management of affected patients. Over the past few years, studies have pointed to a regulatory role for the hemostatic protein, von Willebrand factor (VWF), in angiogenesis, providing a novel target for the modulation of vessel development...
May 5, 2017: Seminars in Thrombosis and Hemostasis
https://www.readbyqxmd.com/read/28467190/risk-of-gastrointestinal-bleeding-during-anticoagulant-treatment
#4
Aitor Lanas-Gimeno, Angel Lanas
Gastrointestinal bleeding (GIB) is a major problem in patients on oral anticoagulation therapy. This issue has become even more pressing since the introduction of direct oral anticoagulants (DOACs) in 2009. Areas covered: Here we review current evidence related to GIB associated with oral anticoagulants, focusing on randomized controlled trials, meta-analyses, and post-marketing observational studies. Dabigatran 150 mg twice daily and rivaroxaban 20 mg once daily increase the risk of GIB compared to warfarin...
June 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/28406792/image-diagnosis-unusual-cause-of-gastrointestinal-bleeding-in-a-young-man-isolated-gastric-angiodysplasias
#5
Sandeep Lamoria, Arka De, Vishal Sharma
No abstract text is available yet for this article.
2017: Permanente Journal
https://www.readbyqxmd.com/read/28395783/review-on-gastrointestinal-angiodysplasia-throughout-the-gastrointestinal-tract
#6
REVIEW
Sabina Beg, Krish Ragunath
Gastrointestinal angiodysplasia are rare but clinically important vascular aberrations found within the gastrointestinal mucosa and submucosa. Their clinical impact varies from being an asymptomatic incidental finding, to causing life threatening bleeding. In this review we critically appraise the key findings from the current literature on the pathology, clinical presentation and management of these lesions.
February 2017: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/28362648/abnormal-angiogenesis-in-blood-outgrowth-endothelial-cells-derived-from-von-willebrand-disease-patients
#7
Soundarya N Selvam, Lara J Casey, Mackenzie L Bowman, Lindsey G Hawke, Avery J Longmore, Jeffrey Mewburn, Mark L Ormiston, Stephen L Archer, Donald H Maurice, Paula James
Bleeding associated with angiodysplasia is a common, often intractable complication in patients with von Willebrand disease (VWD). von Willebrand factor (VWF), the protein deficient or defective in VWD, is a negative regulator of angiogenesis, which may explain the pathologic blood vessel growth in VWD. This study explores the normal range of angiogenesis in blood outgrowth endothelial cells (BOECs) derived from healthy donors and compares this to angiogenesis in BOECs from VWD patients of all types and subtypes...
March 30, 2017: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/28341559/-moyamoya-disease-associated-with-kidney-angiodysplasia-in-a-child
#8
A Dibi, Z Maana, F Jabourik, A Bentahila
INTRODUCTION: Moyamoya disease is a progressive, chronic occlusive vascular disease of the circle of Willis arteries leading to the development of collateral circulation to compensate the occlusion. CASE REPORT: An 11-year-old girl presented an abrupt loss of consciousness and a right-sided motor deficit. Clinical examination found hypertension with 220/120mmHg arterial blood pressure. Brain magnetic resonance imaging showed a large left hemispheric ischemic lesion...
May 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28340821/incidence-management-and-risk-factors-for-lower-gastrointestinal-bleeding-in-renal-transplant-recipients
#9
A Rencuzogullari, S Binboga, E Aytac, J Rabets, L Stocchi, G Ozuner
BACKGROUND: There are limited convincing data regarding management and outcomes of lower gastrointestinal bleeding (LGB) in renal transplant recipients (RTR). The aim of this study was to evaluate incidence, management strategies, and risk factors associated with LGB in RTR. METHODS: Between January 2004 and December 2013, RTR with LGB were analyzed. LGB was defined as having clinical evidence of hemorrhage after upper gastrointestinal etiology was ruled out. RESULTS: There were 1578 RTR with a mean age of 50 ± 14 years at the time of transplantation...
April 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28280628/multiple-angiodysplasia-diagnosed-by-capsule-endoscopy
#10
Giulia Diamantini, Giovanni Battista Levi Sandri, Fabio Procacciante
A 28-year-old Caucasian man was admitted in our unit for acute massive rectal bleeding. Past medical and family history was unremarkable. Hemoglobin was 7.6 g/dL. Blood transfusions were required. Computed tomography and gastrointestinal endoscopy were negative for active bleeding. When patient's hemoglobin was normalized and stable, a video capsule endoscopy was performed. Video relieved the presence of multiple digiunal and ileal angiodysplastic lesions. A double endoscopic argon plasma coagulation procedure was planned on general anaesthesia...
February 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28268536/segmentation-of-angiodysplasia-lesions-in-wce-images-using-a-map-approach-with-markov-random-fields
#11
Pedro M Vieira, Bruno Goncalves, Carla R Goncalves, Carlos S Lima
This paper deals with the segmentation of angiodysplasias in wireless capsule endoscopy images. These lesions are the cause of almost 10% of all gastrointestinal bleeding episodes, and its detection using the available software presents low sensitivity. This work proposes an automatic selection of a ROI using an image segmentation module based on the MAP approach where an accelerated version of the EM algorithm is used to iteratively estimate the model parameters. Spatial context is modeled in the prior probability density function using Markov Random Fields...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28258930/the-impact-of-hospitalization-on-the-performance-of-capsule-endoscopy-ce
#12
Heinz Albrecht, Marcel Vetter, Wolfgang Dauth, Flavius Zoicas, Markus Friedrich Neurath, Alexander Fritzkarl Hagel
BACKGROUND: For proper evaluation of capsule endoscopy (CE), a complete examination is necessary. AIM: We evaluated risk factors of an incomplete CE with focus on patient hospitalization. METHODS: We retrospectively evaluated 161 consecutive patients who underwent CE between 01.07.2013 and 13.03.2016. Main indications were active bleeding, iron deficiency anemia (IDA), inflammatory bowel disease (IBD), abdominal pain, and familial adenomatous polyposis (FAP)...
February 20, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28226712/segmentation-of-angiodysplasia-lesions-in-wce-images-using-a-map-approach-with-markov-random-fields
#13
Pedro M Vieira, Bruno Goncalves, Carla R Goncalves, Carlos S Lima, Pedro M Vieira, Bruno Goncalves, Carla R Goncalves, Carlos S Lima, Pedro M Vieira, Carla R Goncalves, Bruno Goncalves, Carlos S Lima
This paper deals with the segmentation of angiodysplasias in wireless capsule endoscopy images. These lesions are the cause of almost 10% of all gastrointestinal bleeding episodes, and its detection using the available software presents low sensitivity. This work proposes an automatic selection of a ROI using an image segmentation module based on the MAP approach where an accelerated version of the EM algorithm is used to iteratively estimate the model parameters. Spatial context is modeled in the prior probability density function using Markov Random Fields...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28209098/the-predictive-value-of-negative-capsule-endoscopy-for-the-indication-of-obscure-gastrointestinal-bleeding-no-reassurance-in-the-long-term
#14
C Van de Bruaene, P Hindryckx, C Snauwaert, D Dooremont, B Vanduyfhuys, L Vandenabeele, M De Vos, D De Looze
BACKGROUND: Capsule Endoscopy (CE) has become the first-line tool to identify an underlying etiology for Obscure Gastrointestinal Bleeding (OGIB) in the small bowel (SB). This study aims to investigate the long-term outcome of patients with a negative CE. METHODS: Retrospective review of standardized application forms of all patients who underwent CE for OGIB at the Ghent University Hospital between 2002 and 2013. Follow-up data on patients with a negative CE result (n=263) were collected by contacting the referring physician...
September 2016: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/28198025/haemoglobin-responses-to-transfusion-in-severe-iron-deficiency-anaemia-potential-impact-of-gastrointestinal-disorders
#15
X Bosch, E Montori, M Guerra-García, J Costa-Rodríguez, M H Quintanilla, P E Tolosa-Chapasian, P Moreno, N Guasch, A López-Soto
BACKGROUND AND OBJECTIVES: Red blood cell (RBC) transfusion may be justified in iron deficiency anaemia (IDA) when an increase in oxygen delivery is needed, as sometimes occurs in subjects with haemoglobin <8·0 mg/dL, serious comorbidities or at risk of cardiovascular instability. Earlier investigations showed that some patients with severe IDA requiring transfusion had lower than expected post-transfusion haemoglobin levels with poorer clinical outcomes than other patients. After hypothesizing that haemoglobin responses to transfusion were different and that the underlying gastrointestinal (GI) disorders causing IDA could be a confounder explaining this association, these responses were analysed in a prospective cohort of IDA adults referred for outpatient GI investigation...
April 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28076941/double-balloon-endoscopy-in-overt-and-occult-small-bowel-bleeding-results-complications-and-correlation-with-prior-videocapsule-endoscopy-in-a-tertiary-referral-center
#16
Carlijn Hermans, Arnold Stronkhorst, Annemarie Tjhie-Wensing, Jan Kamphuis, Bas van Balkom, Rob Dahlmans, Lennard Gilissen
BACKGROUND/AIMS: Videocapsule endoscopy (VCE) and double-balloon endoscopy (DBE) allow deep exploration in patients with suspected small bowel pathology. VCE is often performed as an initial small bowel examination to explore whether an intervention by DBE is indicated and to determine insertion route. The study aim was to evaluate the correlation between DBE and VCE in patients with obscure or overt bleeding or anemia, as well as intervention frequency, and complications. METHODS: Retrospective observational study...
January 2017: Clinical Endoscopy
https://www.readbyqxmd.com/read/28065528/a-comprehensive-evaluation-of-the-gastrointestinal-tract-in-iron-deficiency-anemia-with-predefined-hemoglobin-below-9mg-dl-a-prospective-cohort-study
#17
Xavier Bosch, Elisabet Montori, Mar Guerra-García, Jaime Costa-Rodríguez, Mariano H Quintanilla, Paula E Tolosa-Chapasian, Pedro Moreno, Neus Guasch, Alfons López-Soto
BACKGROUND: Anemia is defined as hemoglobin below the cutoff of normal in studies examining the gastrointestinal (GI) tract in iron-deficiency anemia (IDA). Although the risk of GI cancer (GIC) increases as hemoglobin decreases, guidelines do not usually recommend hemoglobin thresholds for IDA investigation. METHODS: To elucidate whether underlying GI disorders explain the different hemoglobin values and clinical outcomes observed initially in IDA patients referred for GI workup, we prospectively investigated the diagnostic yield of a thorough GI examination in consecutive IDA adults with predefined hemoglobin <9g/dL and no extraintestinal bleeding...
April 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28065527/iron-deficiency-anemia-despite-effective-gluten-free-diet-in-celiac-disease-diagnostic-role-of-small-bowel-capsule-endoscopy
#18
Konstantinos Efthymakis, Angelo Milano, Francesco Laterza, Mariaelena Serio, Matteo Neri
BACKGROUND & AIM: Iron deficiency anemia (IDA) is associated with celiac disease (CD). Although gluten-free diet (GFD) is an efficient treatment for CD, IDA remains an occasional finding during follow-up and correlates to inadequate gluten exclusion. Little is known regarding persistent IDA despite effective GFD. We aimed to evaluate the role of small bowel capsule endoscopy (SBCE) in this setting. METHODS: We prospectively included consecutive patients undergoing GFD for ≥24 months with persistent concomitant IDA...
April 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28003433/angiodysplasia-in-embryo-lacking-protein-arginine-methyltransferase-1-in-vascular-endothelial-cells
#19
Tomohiro Ishimaru, Junji Ishida, Jun-Dal Kim, Hayase Mizukami, Kanako Hara, Misuzu Hashimoto, Ken-Ichi Yagami, Fumihiro Sugiyama, Akiyoshi Fukamizu
Protein arginine methyltransferase 1 (PRMT1) is involved in multiple cellular functions including proliferation and differentiation. Although PRMT1 is expressed in vascular endothelial cells (ECs), which are responsible for angiogenesis during embryonic development, its role has remained elusive. In this study, we generated endothelial-specific prmt1-knockout (Prmt1-ECKO) mice, and found that they died before embryonic day 15. The superficial temporal arteries in these embryos were poorly perfused with blood, and whole-mount 3D imaging revealed dilated and segmentalized luminal structures in Prmt1-ECKO fetuses in comparison with those of controls...
March 1, 2017: Journal of Biochemistry
https://www.readbyqxmd.com/read/27908518/gastrointestinal-angiodysplasia-diagnosis-and-management
#20
REVIEW
Christian S Jackson, Richard Strong
Gastrointestinal angiodysplasia (GIAD) are red flat arborized lesions that are found throughout the entire gastrointestinal tract. GIAD can vary in size and have a range of presentation from occult to life-threatening bleeding. The typical presentation is intermittent bleeding in the setting of iron deficiency anemia. Endoscopy is the primary means of diagnosis and endoscopic therapy is noted to be initially effective. However, rebleeding can be as high as 40% to 50% in patients with small bowel GIAD. This review describes the pathophysiology for the development of GIAD and the current roles of endoscopic, medical, and surgical therapy in its treatment...
January 2017: Gastrointestinal Endoscopy Clinics of North America
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