Lia C M J Goltstein, Karina V Grooteman, Lucas H P Bernts, Robert C H Scheffer, Robert J F Laheij, Lennard P L Gilissen, Ruud W M Schrauwen, Nynke C Talstra, Abraham T Zuur, Henri Braat, Muhammed Hadithi, Johannes T Brouwer, Wouter B Nagengast, Frank A Oort, Jacco Tenthof van Noorden, Wietske Kievit, Erwin J M van Geenen, Joost P H Drenth
BACKGROUND AND AIMS: Gastrointestinal angiodysplasias are vascular anomalies that may result in transfusion-dependent anemia despite endoscopic therapy. An individual patient data meta-analysis of cohort studies suggests that octreotide decreases rebleeding rates, but component studies possessed a high risk of bias. We aimed to investigate the efficacy of octreotide in reducing the transfusion requirements of patients with angiodysplasia-related anemia in a clinical trial setting. METHODS: The study was designed as a multicenter, open-label, randomized controlled trial...
December 27, 2023: Gastroenterology