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https://www.readbyqxmd.com/read/30004233/cu-i-catalyzed-coupling-and-cycloisomerization-of-diazo-compounds-with-terminal-yne-alkylidenecyclopropanes-synthesis-of-functionalized-cyclopenta-b-naphthalene-derivatives
#1
Peng-Hua Li, Liu-Zhu Yu, Xiao-Yu Zhang, Min Shi
A Cu(I)-catalyzed coupling and cycloisomerization of diazo compounds with terminal yne-alkylidenecyclopropanes (ACPs) has been presented. This reaction starts from the formation of an allenic intermediate in the Cu(I)-catalyzed cross-coupling reaction of a diazo compound with terminal alkyne in yne-tethered ACP and then undergoes a domino cycloisomerization of a 6π-electrocyclization and cyclopropane ring-opening rearrangement to give functionalized cyclopenta[ b]naphthalene derivatives in moderate to excellent yields under mild conditions...
July 13, 2018: Organic Letters
https://www.readbyqxmd.com/read/29996365/-electronic-probe-analysis-of-enamel-remineralization-effect-of-casein-phosphopeptide-amorphous-calcium-phosphate-promoted-by-different-concentrations-of-fluorine
#2
L Liu, M Zou
Objective: To evaluate the remineralization effect and mechanism of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) with different concentrations of fluorine on demineralized enamel using electronic probe. Methods: Extracted premolar teeth for orthodontic purpose were immersed into lactic acid gel to prepare artificial white spot lesions (10 teeth in each group). Then the specimens were randomly assigned to three groups: Control group, with 5% of the CPP-ACP+deionized water; Group A with 5% CPP-ACP+500 mg/L F(-) and Group B with 5% CPP-ACP+900 mg/L F(-)...
July 9, 2018: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/29995983/biosynthesis-of-the-yellow-xanthomonadin-pigments-involves-an-atp-dependent-3-hba-acp-ligase-and-an-unusual-type-ii-polyketide-synthase-pathway
#3
Xue-Qiang Cao, Jia-Yuan Wang, Lian Zhou, Bo Chen, Yu Jin, Ya-Wen He
Xanthomonadins are yellow pigments that are produced by the phytopathogen Xanthomonas campestris pv. campestris (Xcc). A pig cluster is responsible for xanthomonadin biosynthesis. Previously, Xcc4014 of the cluster was characterized as a bifunctional chorismatase that produces 3-hydroxybenzoic acid (3-HBA) and 4-HBA. In this study, genetic analysis identified 11 genes within the pig cluster to be essential for xanthomonadin biosynthesis. Biochemical and bioinformatics analysis suggest that xanthomonadins are synthesized via an unusual type II polyketide synthase pathway...
July 11, 2018: Molecular Microbiology
https://www.readbyqxmd.com/read/29988235/efficacy-of-erbium-doped-yttrium-aluminum-garnet-laser-with-casein-phosphopeptide-amorphous-calcium-phosphate-with-and-without-fluoride-for-remineralization-of-white-spot-lesions-around-orthodontic-brackets
#4
Sogra Yassaei, Hossein Aghili, Neda Shahraki, Isa Safari
Objective: This study aimed to assess the efficacy of erbium-doped yttrium aluminum garnet (Er:YAG) laser, pastes containing casein phosphopeptide amorphous calcium phosphate (CPP-ACP) with and without fluoride and their combination for prevention of white spot lesions in the enamel. Materials and Methods: This in vitro experimental study was conducted on 90 extracted sound premolars. The teeth were then randomly divided into six groups of 15: (1) Control, (2) laser, (3) CPP-ACP with fluoride (GC MI Paste, Recaldent™ 900 ppm as NaF), (4) CPP-ACP without fluoride (GC Tooth Mousse Recaldent™), (5) laser + CPP-ACP with fluoride, and (6) laser + CPP-ACP without fluoride...
April 2018: European Journal of Dentistry
https://www.readbyqxmd.com/read/29986828/successes-challenges-and-impact-of-a-large-cohort-preclinical-interprofessional-curriculum-a-four-year-reflection
#5
Leslie Woltenberg, Stacy Taylor
BACKGROUND: Accreditation Council for Pharmacy Education (ACPE) Standards 2016 established a new standard on interprofessional education (IPE) to place specific emphasis on developing interprofessional competence among pharmacy graduates. INTERPROFESSIONAL EDUCATION ACTIVITY: Interprofessional Collaboration And Team Skills (iCATS) serves as the core interprofessional curriculum for nearly 700 first-year students in seven participating health professional programs...
May 2018: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29985748/do-patients-with-advanced-cancer-have-the-ability-to-make-informed-decisions-for-participation-in-phase-i-clinical-trials
#6
Fay J Hlubocky, Greg A Sachs, Eric R Larson, Halla S Nimeiri, David Cella, Kristen E Wroblewski, Mark J Ratain, Jeffery M Peppercorn, Christopher K Daugherty
Purpose Patients with advanced cancer (ACPs) participating in phase I clinical trials inadequately understand many elements of informed consent (IC); however, the prevalence and impact of cognitive impairment has not been described. Patients and Methods ACPs enrolled onto phase I trials underwent neuropsychological assessment to evaluate cognitive functioning (CF) covering the following domains: memory (Hopkins Verbal Learning Test), executive functioning (Trail Making Test B), language (Boston Naming Test-Short Version and Controlled Oral Word Association Test), attention (Trail Making Test A and Wechsler Adult Intelligenence Scale-IV Digit Span), comprehension (Wechsler Adult Intelligence Scale-IV), and quality of life (Functional Assessment of Cancer Therapy-Cognitive Function)...
July 9, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29985728/associations-of-circulating-cell-free-microrna-with-vasculopathy-and-vascular-events-in-systemic-lupus-erythematosus-patients
#7
S D Kay, A L Carlsen, A Voss, M Burton, Acp Diederichsen, M K Poulsen, Nhh Heegaard
OBJECTIVE: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a high risk of atherosclerosis and cardiovascular disease (CVD). MicroRNAs (miRNAs) are small non-coding RNAs that modulate protein translation, and dysregulation is seen in autoimmunity, atherosclerosis, and CVD. We investigate associations between circulating miRNAs and markers of atherosclerosis in SLE patients. METHOD: A group (n = 121) of well-characterized SLE patients were screened for atherosclerosis by cardiac computed tomography and carotid ultrasound...
July 9, 2018: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/29979678/factors-associated-with-advance-directives-completion-among-patients-with-advance-care-planning-communication-in-taipei-taiwan
#8
Dachen Chu, Yung-Feng Yen, Hsiao-Yun Hu, Yun-Ju Lai, Wen-Jung Sun, Ming-Chung Ko, Li-Ying Huang, Chu-Chieh Chen, J Randall Curtis, Ya-Ling Lee, Sheng-Jean Huang
BACKGROUND: Although advance directives (AD) have been implemented for years in western countries, the concept of AD is not promoted extensively in eastern countries. In this study we evaluate a program to systematically conduct advance care planning (ACP) communication for hospitalized patients in Taiwan and identify the factors associated with AD completion. METHODS: In this retrospective evaluation of a clinical ACP program, we identified adult patients with chronic life-limiting illness admitted to Taipei City Hospital between April 2015 and January 2016...
2018: PloS One
https://www.readbyqxmd.com/read/29978629/legal-and-ethical-issues-surrounding-advance-care-directives-in-australia-implications-for-the-advance-care-planning-document-in-the-australian-my-health-record
#9
Shaun McCarthy, Jacqueline Meredith, Lucy Bryant, Bronwyn Hemsley
This article reviews legal and scientific literature relating to Advance Care Planning (ACP) and Advance Care Directives (ACDs) in Australia, for information about (a) opportunities or benefits of ACP and ACDs and (b) risks, barriers or difficulties in relation to ACP and ACDs. These are discussed in relation to
November 2017: Journal of Law and Medicine
https://www.readbyqxmd.com/read/29975784/slic-is-a-surface-displayed-lipoprotein-that-is-required-for-the-anti-lysozyme-strategy-during-neisseria-gonorrhoeae-infection
#10
Ryszard A Zielke, Adriana Le Van, Benjamin I Baarda, Marco F Herrera, Christopher J Acosta, Ann E Jerse, Aleksandra E Sikora
Lysozymes are nearly omnipresent as the first line of immune defense against microbes in animals. They exert bactericidal action through antimicrobial peptide activity and peptidoglycan hydrolysis. Gram-negative bacteria developed several weapons to battle lysozymes, including inhibitors of c-type lysozymes in the MliC/PliC family and the Neisseria adhesin complex protein (ACP). Until the recent discovery of ACP, no proteinaceous lysozyme inhibitors were reported for the genus Neisseria, including the important human pathogen N...
July 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29973066/health-care-provider-personal-religious-preferences-and-their-perspectives-on-advance-care-planning-with-patients
#11
Marjorie Bowman, Sarah St Cyr, Adrienne Stolf I
OBJECTIVE: To understand how health-care providers' (HCPs) religious preferences influence their willingness to undertake advance care planning (ACP) with patients and their acceptance of other HCP's involvement. METHODS: Online anonymous survey distributed to HCPs in hospital, ambulatory offices, and hospice settings in Dayton, Ohio. We evaluated the associations of HCP religion with their personal ACP, willingness to facilitate ACP, and acceptance of other HCPs' ACP participation...
January 1, 2018: American Journal of Hospice & Palliative Care
https://www.readbyqxmd.com/read/29972979/-effects-of-casein-phosphopeptide-amorphic-calcium-phosphate-on-enamel-erosion-an-in-situ-study
#12
X Y Ye, H Y Zheng, S L Cheng, H Cheng, H Yu
Objective: To evaluate the effects of casein phosphopeptide-amorphic calcium phosphate (CPP-ACP) on enamel erosion using an improved in situ experimental protocol. Methods: Forty-eight enamel blocks were prepared from fresh-extracted human premolars and further embedded in the acrylic resins. The present study was divided into 2 parts. In part 1 of the study, two volunteers were recruited to test the availability and safety of the in situ erosion protocol. Customized intraoral appliance was made with 4 reservoirs containing the specimens for each volunteer...
March 9, 2018: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/29971087/evidence-for-the-involvement-of-fatty-acid-biosynthesis-and-degradation-in-the-formation-of-insect-sex-pheromone-mimicking-chiloglottones-in-sexually-deceptive-chiloglottis-orchids
#13
Darren C J Wong, Ranamalie Amarasinghe, Eran Pichersky, Rod Peakall
Hundreds of orchid species secure pollination by sexually luring specific male insects as pollinators by chemical and morphological mimicry. Yet, the biochemical pathways involved in the synthesis of the insect sex pheromone-mimicking volatiles in these sexually deceptive plants remain poorly understood. Here, we explore the biochemical pathways linked to the chemical mimicry of female sex pheromones (chiloglottones) employed by the Australian sexually deceptive Chiloglottis orchids to lure their male pollinator...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29967162/an-aryl-homoserine-lactone-quorum-sensing-signal-produced-by-a-dimorphic-prosthecate-bacterium
#14
Lisheng Liao, Amy L Schaefer, Bruna G Coutinho, Pamela J B Brown, E Peter Greenberg
Many species of Proteobacteria produce acyl-homoserine lactone (AHL) compounds as quorum-sensing (QS) signals for cell density-dependent gene regulation. Most known AHL synthases, LuxI-type enzymes, produce fatty AHLs, and the fatty acid moiety is derived from an acyl-acyl carrier protein (ACP) intermediate in fatty acid biosynthesis. Recently, a class of LuxI homologs has been shown to use CoA-linked aromatic or amino acid substrates for AHL synthesis. By using an informatics approach, we found the CoA class of LuxI homologs exists primarily in α-Proteobacteria...
July 2, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29965745/is-there-a-precipitation-sequence-in-municipal-wastewater-induced-by-electrolysis
#15
Yang Lei, Jorrit Christiaan Remmers, Michel Saakes, Renata van der Weijden, Cees J N Buisman
Electrochemical wastewater treatment can induce calcium phosphate precipitation on the cathode surface. This provides a simple yet efficient way for extracting phosphorus from municipal wastewater without dosing chemicals. However, the precipitation of amorphous calcium phosphate (ACP) is accompanied by the precipitation of calcite (CaCO3) and brucite (Mg(OH)2). To increase the content of ACP in the products, it is essential to understand the precipitation sequence of ACP, calcite and brucite in electrochemical wastewater treatment...
July 2, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29959091/asian-citrus-psyllid-stylet-morphology-and-applicability-to-the-model-for-inter-instar-stylet-replacement-in-the-potato-psyllid
#16
Joseph M Cicero, Javier Alba-Tercedor, Wayne B Hunter, Liliana M Cano, S Saha, Lukas A Mueller, Susan J Brown
In Hemiptera, presumptive stylets for each consecutive postembryonic instar are manufactured prior to ecdysis to replace the ecdysial stylets discarded with the exuviae. With the discovery that the bacterium "Candidatus" Liberibacter solanacearum accesses the tissues involved in the stylet replacement process of the potato psyllid, a hypothesis was formed that the bacterium could adhere to the stylets of freshly emerged instars and hence gain access to the host plant when feeding is resumed. Although unproven, it was imperative that a model for stylet replacement be built...
June 26, 2018: Arthropod Structure & Development
https://www.readbyqxmd.com/read/29959041/coupling-xylitol-with-remineralizing-agents-improves-tooth-protection-against-demineralization-but-reduces-antibiofilm-effect
#17
Wafa Gargouri, Tarek Zmanter, Rym Kammoun, Nabil Kechaou, Sonia Ghoul-Mazgar
To explore the efficiency of xylitol chewing gum enriched or not with remineralizing agents to protect tooth against cariogenic biofilm formation and demineralization. Six groups of chewing gums were prepared; Group 1: isomalt (1.8%), Group 2: casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) (3%) + isomalt (1.8%), Group 3: hydroxyapatite (HAP) (2.5%) + isomalt (1.8%), Group 4: xylitol (1.8%), Group 5: CPP-ACP (3%) + xylitol (1.8%) and Group 6: HAP (2.5%) + xylitol (1.8%). The antibiofilm properties of different chewing gum extracts using six oral bacterial species including Streptococcus mutans, Streptococcus constellatus, Streptococcus Salivarius and Streptococcus oralis were explored via the crystal violet staining assay...
June 26, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29946330/identification-and-phenotypic-characterization-of-zebra-leaf16-encoding-a-%C3%AE-hydroxyacyl-acp-dehydratase-in-rice
#18
Ziwen Liu, Zhiyuan Wang, Han Gu, Jia You, Manman Hu, Yujun Zhang, Ze Zhu, Yihua Wang, Shijia Liu, Liangming Chen, Xi Liu, Yunlu Tian, Shirong Zhou, Ling Jiang, Linglong Liu, Jianmin Wan
The chloroplast is a self-independent organelle and contains its own transcription and translation systems. The establishment of genetic systems is vital for normal plant growth and development. We isolated a rice zebra leaf 16 ( zl16 ) mutant derived from rice cultivar 9311. The zl16 mutant showed chlorotic abnormalities in the transverse sectors of the young leaves of seedlings. The use of transmission electron microscopy (TEM) demonstrated that dramatic defects occurred in variegated zl16 leaves during the early development of a chloroplast...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29942808/assessment-of-canine-autologous-conditioned-plasma-tm-cellular-and-transforming-growth-factor-%C3%AE-1-content
#19
Samuel P Franklin, Kate E Birdwhistell
To evaluate (1) the cellular composition of canine ACP™ including using two different preparation protocols with variations on centrifugation time, (2) the effect of different activation protocols on the transforming growth factor (TGF)-β1 content in the ACP, and (3) patient factors that might influence platelet concentration of the ACP. ACP was made with blood from 15 dogs using a manufacturer-recommended protocol. Each ACP sample was divided into three aliquots that were activated with calcium chloride (CaCl2 ), human γ-thrombin (HGT), or not activated...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29941260/phosphine-production-in-anaerobic-wastewater-treatment-under-tetracycline-antibiotic-pressure
#20
Meiqing Lu, Xiaojun Niu, Weiyi Chen, Zhu Liang, Sheng You, Xiaohong Gu
The influence of tetracycline (TC) antibiotics on phosphine (PH3 ) production in the anaerobic wastewater treatment was studied. A lab-scale anaerobic baffled reactor with three compartments was employed to simulate this process. The reactor was operated in a TC-absence wastewater and 250μg/L TC-presence wastewater for three months after a start-up period, respectively. The responses of pH, oxidation-reduction potential (ORP), chemical oxygen demand (COD), total phosphorus (TP), enzymes activity (dehydrogenase and acid phosphatase), and microbial community were investigated to reveal the effect of TC on PH3 production...
July 2018: Journal of Environmental Sciences (China)
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