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Kristie B Hadden, Connie L Arnold, Laura M Curtis, Jennifer M Gan, Scott Hur, Mary Kwasny, Jean C McSweeney, Latrina Y Prince, Michael S Wolf, Terry C Davis
Proper diabetes self-care requires patients to have considerable knowledge, a range of skills, and to sustain multiple health behaviors. Self-management interventions are needed that can be readily implemented and sustained in rural clinics with limited resources that disproportionately care for patients with limited literacy. Researchers on our team developed an evidence-based, patient-centered, low literacy intervention promoting diabetes self-care that includes: 1) the American College of Physicians (ACP) Diabetes Guide that uses plain language and descriptive photographs to teach core diabetes concepts and empower patients to initiate behavior change; 2) a brief counseling strategy to assist patients in developing short-term, explicit and attainable goals for behavior change ('action plans'); and 3) a training module for health coaches that prepares them to assume educator/counselor roles with the Diabetes Guide as a teaching tool...
September 19, 2018: Contemporary Clinical Trials
Woo Cheol Lee, Jungwoo Park, Pavithra K Balasubramanian, Yangmee Kim
Bacterial fatty acid synthesis (FAS) has been extensively studied as a potential target of antimicrobials. In FAS, FabD mediates transacylation of the malonyl group from malonyl-CoA to acyl-carrier protein (ACP). The mounting threat of nosocomial infection by multidrug-resistant Acinetobacter baumannii warrants a deeper understanding of its essential cellular mechanisms, which could lead to effective control of this highly competent pathogen. The molecular mechanisms involved in A. baumannii FAS are poorly understood, and recent research has suggested that Pseudomonas aeruginosa, a closely related nosocomial pathogen of A...
September 19, 2018: Biochemical and Biophysical Research Communications
Junguo Ma, Xinxin Li, Mengke Cui, Weiguo Li, Xiaoyu Li
This study aimed to determine the chronic toxicity of the ionic liquid (IL) 1-methyl-3-octylimidazolium bromide ([C8 mim]Br) on silver carp to further study the toxicological mechanism of ILs. For this purpose, 60-d chronic exposure at concentrations of 1.09 or 4.38 mg L-1 [C8 mim]Br in silver carp was conducted. The results of biochemical assays revealed that [C8 mim]Br-treatment remarkably promoted serum lactate dehydrogenase (LDH), aspartate aminotransferase (AST), alanine aminotransferase (ALT), acid phosphatase (ACP), and alkaline phosphatase (AKP) activities, indicating that [C8 mim]Br-exposure caused fish organ damage...
September 15, 2018: Chemosphere
Matthew R Aronson, Andrew W Simonson, Lindsey M Orchard, Manuel Llinás, Scott H Medina
Anticancer peptides (ACPs) are cationic amphiphiles that preferentially kill cancer cells through folding-dependent membrane disruption. Although ACPs represent attractive therapeutic candidates, particularly against drug-resistant cancers, their successful translation into clinical practice has gone unrealized due to their poor bioavailability, serum instability and, most importantly, severe hemolytic toxicity. Here, we exploit the membrane-specific interactions of ACPs to prepare a new class of peptide-lipid particle, we term a lipopeptisome (LP)...
September 18, 2018: Acta Biomaterialia
Yi Liu, Song-Tao Qi, Chao-Hu Wang, Jun Pan, Jun Fan, Jun-Xiang Peng, Xi'an Zhang, Yun Bao, Ya-Wei Liu
The aim of this study was to clarify pathological and anatomical relationships between adamantinomatous craniopharyngiomas (ACP) and their surrounding structures. We previously established a QST classification scheme based on the apparent anatomic origin of the tumors. According to this classification, 13 type Q tumors, 6 type S tumors, and 42 type T ACPs were analyzed. Type Q tumors, which are most likely to involve the pituitary gland, did not invade the area of contact with the adenohypophysis. Instead, tumor invasion was observed in areas where the tumor contacted the neurohypophysis...
September 14, 2018: Journal of Neuropathology and Experimental Neurology
Naomi N K Kreamer, Rajiv Chopra, Ruth E Caughlan, Doriano Fabbro, Eric Fang, Patricia Gee, Ian Hunt, Min Li, Barbara C Leon, Lionel Muller, Brian Vash, Angela L Woods, Travis Stams, Charles R Dean, Tsuyoshi Uehara
Phosphorylation of Pseudomonas aeruginosa lipopolysaccharide (LPS) is important for maintaining outer membrane integrity and intrinsic antibiotic resistance. We solved the crystal structure of the LPS heptose kinase WaaP, which is essential for growth of P. aeruginosa. WaaP was structurally similar to eukaryotic protein kinases and, intriguingly, was complexed with acylated-acyl carrier protein (acyl-ACP). WaaP produced by in vitro transcription-translation was insoluble unless acyl-ACP was present. WaaP variants designed to perturb the acyl-ACP interaction were less stable in cells and exhibited reduced kinase function...
September 20, 2018: Scientific Reports
Carol Motycka, Eric F Egelund, Jane Gannon, Frank Genuardi, Shiva Gautam, Shannon Stittsworth, Amanda Young, Leslie Simon
BACKGROUND: We developed and implemented a project incorporating ACPE Standard 11 and all Core IPEC competencies at a public University located at a medical center. The project was a collaboration between the colleges of nursing, pharmacy, and medicine at a distance campus location. INTERPROFESSIONAL EDUCATION ACTIVITY: Our Interprofessional Education Activity, which targeted all three elements of ACPE Standard 11, provided TeamSTEPPS® training followed by four medical error simulations...
July 2018: Currents in Pharmacy Teaching & Learning
Maria Miller Thurston, Jill Augustine, C Lea Bonner
BACKGROUND: Professionalism in pharmacy students is an area of great focus with the release of Accreditation Council for Pharmacy Education (ACPE) Standards 2016. This study assessed and compared student pharmacists' professionalism at one college of pharmacy to inform the implementation of a co-curricular professional engagement program. METHODS: Two validated instruments (Behavioral Professionalism Assessment Instrument [BPAI] and Pharmacy Professionalism Instrument [PPI]) were administered to assess baseline professionalism...
July 2018: Currents in Pharmacy Teaching & Learning
Nina Bendelin, Björn Gerdle, Gerhard Andersson
Purpose: Methods for delivering aftercare to help chronic pain patients to continue practice self-management skills after rehabilitation are needed. Internet-delivered cognitive behavioral therapy (ICBT) has the potential to partly fill this gap given its accessibility and emphasis on self-care. Methods for engaging and motivating patients to persist throughout the full length of treatment are needed. The aim of this study was to describe how chronic pain patients work in an ICBT program, through their descriptions of what is important when they initiate behavior change in aftercare and their descriptions of what is important for ongoing practice of self-management skills in aftercare...
2018: Journal of Pain Research
Victoria Wu, Sean Tang, Vuk Uskokovic
Cheap and simple to make, calcium phosphate (CP), thanks to its unusual functional pleiotropy, belongs to the new wave of abundant and naturally accessible nanomaterials applicable as a means to various technological ends. It is used in a number of industries, including the biomedical, but its intrinsic antibacterial activity in the nanoparticle form has not been sufficiently explored to date. In this study we report on this intrinsic antibacterial effect exhibited by two distinct CP phases: an amorphous CP (ACP) and hydroxyapatite (HAp)...
September 18, 2018: ACS Applied Materials & Interfaces
Shrinivas D Joshi, Sheshagiri R Dixit, Jeelan Basha, V H Kulkarni, Tejraj M Aminabhavi, Mallikarjuna N Nadagouda, Christian Lherbet
In an effort to produce new lead antimycobacterial compounds, herein we have reported the synthesis of a sequence of new pyrrolyl benzamide derivatives. The new chemical entities were screened to target enoyl-ACP reductase enzyme, which is one of the key enzymes of M. tuberculosis that are involved in type II fatty acid biosynthetic pathway. Compound 3q exhibited H-bonding interactions with Tyr158, Thr196 and co-factor NAD+ that binds the active site of InhA. All the pyrrolyl benzamide compounds were evaluated as inhibitors of M...
August 28, 2018: Bioorganic Chemistry
Richard E Leiter, Miryam Yusufov, Mohammad Adrian Hasdianda, Lauren A Fellion, Audrey C Reust, Susan D Block, James A Tulsky, Kei Ouchi
CONTEXT: Emergency Department (ED) visits provide opportunities to empower patients to discuss advance care planning (ACP) with their outpatient clinicians, but systematically developed, feasible interventions do not currently exist. Brief negotiated interview (BNI) interventions, which allow ED clinicians to efficiently motivate patients, have potential to meet this need. OBJECTIVES: We developed a BNI ED intervention to empower older adults with life-limiting illness to formulate and communicate medical care goals to their primary outpatient clinicians...
September 14, 2018: Journal of Pain and Symptom Management
José A B Bezerra, Andréia M Silva, Patrícia C Sousa, Lívia B Campos, Érica C G Praxedes, Luana G P Bezerra, Thibério S Castelo, Ana L P Souza, Alexandre R Silva
SummaryThe aim of this study was to establish a functional freezing-thawing protocol for epididymal sperm of collared peccaries (Pecari tajacu L., 1758) by comparing different extenders. The epididymal sperm from 12 sexually mature males was recovered by retrograde flushing using Tris-based or coconut water-based (ACP®-116c) extenders. After initial evaluation, samples were diluted and frozen with the same extenders to which 20% egg yolk and 6% glycerol were added. After 2 weeks, thawing was performed at 37°C/60 s and sperm motility, vigour, morphology, functional membrane integrity, sperm viability, sperm plasma membrane integrity, and a computer-assisted semen analysis (CASA) were assessed...
September 17, 2018: Zygote: the Biology of Gametes and Early Embryos
Katherine B Curtin, Yao I Cheng, Jichuan Wang, Rachel K Scott, Leah Squires, Debra A Benator, Maureen E Lyon
PURPOSE: Physicians and caregivers rate patient quality of life (QOL) lower than patients rate their own QOL. This study investigated discrepancies between self-assessments of patient QOL by adults with HIV and their surrogate decision-makers. METHODS: We collected baseline data from 223 adult dyads in the FAmily-CEntered (FACE) Advance Care Planning (ACP) clinical trial, consisting of HIV positive patients and their chosen surrogates. Participants independently completed the Medical Outcome Study-HIV Survey (MOS-HIV) and the Palliative care Outcome Scale (POS)...
September 15, 2018: Quality of Life Research
Maryland Pao, Margaret Rose Mahoney
This article describes the preparation, rationale, and benefits of talking with adolescents who have life-threatening or life-limiting illness about advance care planning (ACP) and end-of-life concerns in a developmentally sensitive manner. The first step is to ensure that a health care provider is ready to work with adolescents in ACP discussions by taking a self-inventory, learning communication skills, and understanding individual barriers. The authors then outline how to assess patient and family readiness, including developmental, cultural, personal, and psychosocial considerations...
October 2018: Child and Adolescent Psychiatric Clinics of North America
Ellen Slungaard, Nicholas D C Green, Di J Newham, Stephen D R Harridge
INTRODUCTION: The prevalence of flight-related neck pain in all Royal Air Force (RAF) aircrew is 66% and 70% in UK fast-jet aircrew. The RAF Aircrew Conditioning Programme (ACP) has been designed to enhance pilot performance through reducing fatigue and strain injuries, particularly to the neck. Content validity of the ACP was assessed to determine the appropriateness for delivery to aircrew. METHODS: Six international medical experts reviewed level two of the ACP, which is delivered to student aircrew who have completed basic instruction in cervical spine stability, core stability and initial technique instruction for strength training...
October 1, 2018: Aerospace Medicine and Human Performance
Jennifer Chow, Dominik Danso, Manuel Ferrer, Wolfgang R Streit
Biotin is an essential cofactor required for carboxylation and decarboxylation reactions in all domains of life. While biotin biosynthesis in most Bacteria and Eukarya is well studied, the complete pathway for this vitamer in Archaea is still not known. Detailed genome searches indicated the presence of possible bio gene clusters only in Methanococcales and Thaumarchaeota. Therefore, we analysed the functionality of the predicted genes bioA, bioB, bioD and bioF in the Thaumarchaeon Nitrososphaera gargensis Ga2...
September 14, 2018: Scientific Reports
Lisa Hauk
No abstract text is available yet for this article.
July 15, 2018: American Family Physician
Yang Yu, Zoltán Bacsik, Mattias Edén
Body-fluid-exposed bioactive glasses (BGs) integrate with living tissues due to the formation of a biomimetic surface layer of calcium hydroxy-carbonate apatite (HCA) with a close composition to bone mineral. Vast efforts have been spent to understand the mechanisms underlying in vitro apatite mineralization, as either formed by direct precipitation from supersaturated solutions, or from BG substrates in a simulated body fluid (SBF). Formally, these two scenarios are distinct and have hitherto been discussed as such...
September 12, 2018: Materials
Satoshi Matsuo, Noritaka Komune, Ryosuke Tsuchimochi, Yasutoshi Kai, Kenichi Matsumoto, Sei Haga, Takuya Inoue
Objective  This study aimed to review the anatomical and clinical characteristics of internal carotid-posterior communicating artery (IC-PC) aneurysms, especially those located close to the skull base. Methods  The microsurgical anatomy around the posterior communicating artery (PComA) was examined in a dry skull and five formalin-fixed human cadaveric heads. The clinical characteristics of 37 patients with 39 IC-PC aneurysms, who were treated microsurgically between April 2008 and July 2016, were retrospectively reviewed...
October 2018: Journal of Neurological Surgery. Part B, Skull Base
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