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https://www.readbyqxmd.com/read/28634302/structure-of-human-fe-s-assembly-subcomplex-reveals-unexpected-cysteine-desulfurase-architecture-and-acyl-acp-isd11-interactions
#1
Seth A Cory, Jonathan G Van Vranken, Edward J Brignole, Shachin Patra, Dennis R Winge, Catherine L Drennan, Jared Rutter, David P Barondeau
In eukaryotes, sulfur is mobilized for incorporation into multiple biosynthetic pathways by a cysteine desulfurase complex that consists of a catalytic subunit (NFS1), LYR protein (ISD11), and acyl carrier protein (ACP). This NFS1-ISD11-ACP (SDA) complex forms the core of the iron-sulfur (Fe-S) assembly complex and associates with assembly proteins ISCU2, frataxin (FXN), and ferredoxin to synthesize Fe-S clusters. Here we present crystallographic and electron microscopic structures of the SDA complex coupled to enzyme kinetic and cell-based studies to provide structure-function properties of a mitochondrial cysteine desulfurase...
June 20, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28632769/combining-omics-and-microscopy-to-visualize-interactions-between-the-asian-citrus-psyllid-vector-and-the-huanglongbing-pathogen-candidatus-liberibacter-asiaticus-in-the-insect-gut
#2
Angela Kruse, Somayeh Fattah-Hosseini, Surya Saha, Richard Johnson, EricaRose Warwick, Kasie Sturgeon, Lukas Mueller, Michael J MacCoss, Robert G Shatters, Michelle Cilia Heck
Huanglongbing, or citrus greening disease, is an economically devastating bacterial disease of citrus. It is associated with infection by the gram-negative bacterium Candidatus Liberibacter asiaticus (CLas). CLas is transmitted by Diaphorina citri, the Asian citrus psyllid (ACP). For insect transmission to occur, CLas must be ingested during feeding on infected phloem sap and cross the gut barrier to gain entry into the insect vector. To investigate the effects of CLas exposure at the gut-pathogen interface, we performed RNAseq and mass spectrometry-based proteomics to analyze the transcriptome and proteome, respectively, of ACP gut tissue...
2017: PloS One
https://www.readbyqxmd.com/read/28632406/tailored-pharmacophore-model-to-enhance-virtual-screening-and-drug-discovery-a-case-study-on-the-identification-of-potential-inhibitors-against-drug-resistant-mycobacterium-tuberculosis-3r-hydroxyacyl-acp-dehydratases
#3
Kgothatso E Machaba, Ndumiso N Mhlongo, Yussif M Dokurugu, Mahmoud Es Soliman
AIM: Virtual screening (VS) is powerful tool in discovering molecular inhibitors that are most likely to bind to drug targets of interest. Herein, we introduce a novel VS approach, so-called 'tailored-pharmacophore', in order to explore inhibitors that overcome drug resistance. Methodology & results: The emergence and spread of drug resistance strains of tuberculosis is one of the most critical issues in healthcare. A tailored-pharmacophore approach was found promising to identify in silico predicted hit with better binding affinities in case of the resistance mutations in MtbHadAB as compared with thiacetazone, a prodrug used in the clinical treatment of tuberculosis...
June 20, 2017: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/28631959/advance-care-planning-for-patients-with-amyotrophic-lateral-sclerosis
#4
Benjamin H Levi, Zachary Simmons, Courtney Hanna, Allyson Brothers, Erik Lehman, Elana Farace, Megan Bain, Renee Stewart, Michael J Green
PURPOSE: To determine whether an advance care planning (ACP) decision-aid could improve communication about end-of-life treatment wishes between patients with amyotrophic lateral sclerosis (ALS) and their clinicians. METHODS: Forty-four patients with ALS (>21, English-speaking, without dementia) engaged in ACP using an interactive computer based decision-aid. Before participants completed the intervention, and again three months later, their clinicians reviewed three clinical vignettes, and made treatment decisions (n = 18) for patients...
March 5, 2017: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
https://www.readbyqxmd.com/read/28627352/-acute-cor-pulmonale-in-acute-respiratory-distress-syndrome
#5
Feng Zhang, Quan Cao, Xiangrong Zuo
Acute respiratory distress syndrome (ARDS) is a severe respiratory condition that is characterized by rapidly progressive hypoxemia with noncardiogenic pulmonary edema. Despite the improvement of therapeutic methods, the mortality of ARDS is in the range of 40%-50% all over the world. Some studies have shown that a significant number of patients with ARDS had acute cor pulmonale (ACP), and ACP is independently associated with the mortality of patients with ARDS, which has attracted wide attention in recent years...
March 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28625421/insights-into-the-anticancer-properties-of-the-first-antimicrobial-peptide-from-archaea
#6
Rosa Gaglione, Luciano Pirone, Biancamaria Farina, Salvatore Fusco, Giovanni Smaldone, Martina Aulitto, Eliana Dell'Olmo, Emanuela Roscetto, Annarita Del Gatto, Roberto Fattorusso, Eugenio Notomista, Laura Zaccaro, Angela Arciello, Emilia Pedone, Patrizia Contursi
BACKGROUND: The peptide VLL-28, identified in the sequence of an archaeal protein, the transcription factor Stf76 from Sulfolobus islandicus, was previously identified and characterized as an antimicrobial peptide, possessing a broad-spectrum antibacterial activity. METHODS: Through a combined approach of NMR and Circular Dichroism spectroscopy, Dynamic Light Scattering, confocal microscopy and cell viability assays, the interaction of VLL-28 with the membranes of both parental and malignant cell lines has been characterized and peptide mechanism of action has been studied...
June 15, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28622978/the-evolution-and-nomenclature-of-gnrh-type-and-corazonin-type-neuropeptide-signaling-systems
#7
REVIEW
Meet Zandawala, Shi Tian, Maurice R Elphick
Gonadotropin-releasing hormone (GnRH) was first discovered in mammals on account of its effect in triggering pituitary release of gonadotropins and the importance of this discovery was recognized forty years ago in the award of the 1977 Nobel Prize for Physiology or Medicine. Investigation of the evolution of GnRH revealed that GnRH-type signaling systems occur throughout the chordates, including agnathans (e.g. lampreys) and urochordates (e.g. sea squirts). Furthermore, the discovery that adipokinetic hormone (AKH) is the ligand for a GnRH-type receptor in the arthropod Drosophila melanogaster provided evidence of the antiquity of GnRH-type signaling...
June 13, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28616770/protective-effect-of-origanum-oil-on-alterations-of-some-trace-elements-and-antioxidant-levels-induced-by-mercuric-chloride-in-male-rats
#8
Naglaa El-Shahat Mohamed
In the current study, 48 male rats were classified into four groups (12 rats/group): 1-control group received 1 ml distilled water, 2-origanum oil group treated daily with oral dose of origanum oil (5 mg/kg) for 30 and 60 days, 3-mercuric chloride group treated daily with oral dose of mercuric chloride (4 mg/kg) for 30 and 60 days, and 4-origanum oil + mercuric chloride group treated with both origanum oil and mercuric chloride (5 and 4 mg/kg, respectively) for 30 and 60 days. All treatments were carried out by stomach tube...
June 14, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28612910/percutaneous-left-atrial-appendage-occlusion-procedures-in-patients-with-heart-failure
#9
Magdalena Szymała, Witold Streb, Katarzyna Mitręga, Tomasz Podolecki, Grzegorz Mencel, Tomasz Kukulski, Zbigniew Kalarus
BACKGROUND: Atrial fibrillation (AF) is the most common supraventricular tachyarrhythmia. The percutaneous left atrial appendage occlusion (LAAO) may be considered for the stroke prophylaxis in patients with nonvalvular AF (NVAF), especially in contraindications for oral anticoagulants (OAC) or high risk of bleeding. The data about implantation, safety, efficacy and follow-up are limited. Moreover, there are no studies on patients with NVAF and heart failure with severe left ventricular systolic dysfunction (left ventricular ejection fraction - LVEF ≤ 35%)...
June 14, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28610838/bcl-2-expression-is-essential-for-development-and-normal-physiological-properties-of-tooth-hard-tissue-and-saliva-production
#10
Mohammad Ali Saghiri, Armen Asatourian, Zafer Gurel, Christine M Sorenson, Nader Sheibani
BACKGROUND: Apoptosis plays a fundamental role in appropriate tissue development and function. Although expression of Bcl-2 has been reported during tooth and submandibular gland (SMG) development, the physiological role Bcl-2 plays during these processes has not been addressed. This study was performed to evaluate the impact of Bcl-2 expression on the formation and properties of tooth hard tissue, and saliva production. METHODS: Twenty-four mice (12 males and 12 females) were divided into three groups of eight (n=8): group A (Bcl-2 +/+), group B (Bcl-2 +/-), and group C (Bcl-2 -/-) and subjected to micro-CT analyses...
June 10, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28608692/galactomannan-from-antrodia-cinnamomea-enhances-the-phagocytic-activity-of-macrophages
#11
Namal Perera, Feng-Ling Yang, Ching-Ming Chang, Yueh-Tung Lu, Shih-Hao Zhan, Yi-Ting Tsai, Jung-Feng Hsieh, Lan-Hui Li, Kuo-Feng Hua, Shih-Hsiung Wu
Galactomannan with an octasaccharide-repeating unit (ACP) was isolated from Taiwan medicinal mushroom Antrodia cinnamomea, and its chemical structure was determined herein. ACP significantly enhanced the phagocytosis and bactericidal activity of J774A.1 murine macrophages against Escherichia coli, with prospects for developing a new immunomodulatory compound or adjuvant in immunotherapy and vaccination.
June 13, 2017: Organic Letters
https://www.readbyqxmd.com/read/28607153/2017-acc-aha-hfsa-ishlt-acp-advanced-training-statement-on-advanced-heart-failure-and-transplant-cardiology-revision-of-the-accf-aha-acp-hfsa-ishlt-2010-clinical-competence-statement-on-management-of-patients-with-advanced-heart-failure-and-cardiac-transplant
#12
REVIEW
Mariell Jessup, Mark H Drazner, Wendy Book, Joseph C Cleveland, Ira Dauber, Susan Farkas, Mahazarin Ginwalla, Jason N Katz, Peggy Kirkwood, Michelle M Kittleson, Joseph E Marine, Paul Mather, Alanna A Morris, Donna M Polk, Antoine Sakr, Kelly H Schlendorf, Esther E Vorovich
No abstract text is available yet for this article.
June 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28606860/effects-of-partial-replacement-of-fish-meal-by-yeast-hydrolysate-on-complement-system-and-stress-resistance-in-juvenile-jian-carp-cyprinus-carpio-var-jian
#13
Xiang-Yang Yuan, Wen-Bin Liu, Chao Liang, Cun-Xin Sun, Yun-Fei Xue, Zu-De Wan, Guang-Zhen Jiang
A 10-week feeding trial was carried out to investigate the effects of dietary fish meal replacement by yeast hydrolysate (YH) on growth performance, complement system and stress resistance of juvenile Jian carp (Cyprinus carpio var. Jian) (initial average weight 19.44 ± 0.06 g). In the study, there were five groups: one control group was fed with a basal diet (YH0), and four treatment groups were fed with dietary fish meal replaced by 1% YH (YH1), 3% (YH3), 5% (YH5) and 7% (YH7), respectively. Each group had four replicates...
June 9, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28601820/axillary-versus-innominate-artery-cannulation-for-antegrade-cerebral-perfusion-in-aortic-surgery-design-of-the-aortic-surgery-cerebral-protection-evaluation-ace-cardiolink-3-randomised-trial
#14
Vinay Garg, Mark D Peterson, Michael Wa Chu, Maral Ouzounian, Roderick Gg MacArthur, John Bozinovski, Ismail El-Hamamsy, F Victor Chu, Ankit Garg, Judith Hall, Kevin E Thorpe, Natasha Dhingra, Hwee Teoh, Thomas R Marotta, David A Latter, Adrian Quan, Muhammad Mamdani, Peter Juni, C David Mazer, Subodh Verma
INTRODUCTION: Neurological injury remains the major cause of morbidity and mortality following open aortic arch repair. Systemic hypothermia along with antegrade cerebral perfusion (ACP) is the accepted cerebral protection approach, with axillary artery cannulation being the most common technique used to establish ACP. More recently, innominate artery cannulation has been shown to be a safe and efficacious method for establishing ACP. Inasmuch as there is a lack of high-quality data comparing axillary and innominate artery ACP, we have designed a randomised, multi-centre clinical trial to compare both cerebral perfusion strategies with regards to brain morphological injury using diffusion-weighted MRI (DW-MRI)...
June 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/28599915/multiplex-polymerase-chain-reaction-for-identification-of-escherichia-coli-escherichia-albertii-and-escherichia-fergusonii
#15
Rebecca L Lindsey, L Garcia-Toledo, D Fasulo, L M Gladney, N Strockbine
Escherichia coli, Escherichia albertii, and Escherichia fergusonii are closely related bacteria that can cause illness in humans, such as bacteremia, urinary tract infections and diarrhea. Current identification strategies for these three species vary in complexity and typically rely on the use of multiple phenotypic and genetic tests. To facilitate their rapid identification, we developed a multiplex PCR assay targeting conserved, species-specific genes. We used the Daydreamer™ (Pattern Genomics, USA) software platform to concurrently analyze whole genome sequence assemblies (WGS) from 150 Enterobacteriaceae genomes (107 E...
June 6, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/28596151/survey-on-advance-care-planning-of-italian-outpatients-on-chronic-haemodialysis
#16
Nicola Panocchia, Giuseppe Tonnara, Roberta Minacori, Dario Sacchini, Maurizio Bossola, Luigi Tazza, Giovanni Gambaro, Antonio Gioacchino Spagnolo
OBJECTIVES: The clinical practice guidelines published by the Renal Physicians Association (USA) recommend instituting advance care planning (ACP) for patients with end-stage renal disease. Studies on this issue are lacking in Italy. Our aim was to determine the attitudes of patients on ACP in our dialysis centre. METHODS: We performed a cross-sectional survey. We recruited patients on maintenance haemodialysis (HD) at Hemodialysis Center of Università Cattolica del Sacro Cuore, from 1 March 2014 to 31 March 2015...
June 8, 2017: BMJ Supportive & Palliative Care
https://www.readbyqxmd.com/read/28592584/utilising-advance-care-planning-videos-to-empower-perioperative-cancer-patients-and-families-a-study-protocol-of-a-randomised-controlled-trial
#17
Rebecca A Aslakson, Sarina R Isenberg, Norah L Crossnohere, Alison M Conca-Cheng, Ting Yang, Matthew Weiss, Angelo E Volandes, John F P Bridges, Debra L Roter
INTRODUCTION: Despite positive health outcomes associated with advance care planning (ACP), little research has investigated the impact of ACP in surgical populations. Our goal is to evaluate how an ACP intervention video impacts the patient centredness and ACP of the patient-surgeon conversation during the presurgical consent visit. We hypothesise that patients who view the intervention will engage in a more patient-centred communication with their surgeons compared with patients who view a control video...
June 6, 2017: BMJ Open
https://www.readbyqxmd.com/read/28589971/on-the-structures-spin-states-and-optical-properties-of-titanium-platinum-and-iron-azacalixphyrins-a-dft-study
#18
Gabriel Marchand, Olivier Siri, Denis Jacquemin
Azacalixphyrins (ACP) constitute a new class of macrocycles isoelectronic and isostructural to porphyrins. Herein, we report the first theoretical investigation of the properties of the ACP macrocycles metallated at their centre by titanium, platinum, and iron ions. We considered both the original phenyl-type ACP and new pyridyl-type forms. Our results indicate that the metallation greatly impacts the global structure of the macrocycle through pseudo Jahn-Teller effects, giving rise to a possible conformational transition between D2d and S4 structures...
June 21, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28586906/irritable-bowel-syndrome
#19
REVIEW
Shahnaz Sultan, Ashish Malhotra
This issue provides a clinical overview of irritable bowel syndrome, focusing on diagnosis, treatment, and practice improvement. The content of In the Clinic is drawn from the clinical information and education resources of the American College of Physicians (ACP), including MKSAP (Medical Knowledge and Self-Assessment Program). Annals of Internal Medicine editors develop In the Clinic in collaboration with the ACP's Medical Education and Publishing divisions and with the assistance of additional science writers and physician writers...
June 6, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28586259/implementation-of-advance-care-planning-in-oncology-a-review-of-the-literature
#20
Christine M Bestvina, Blase N Polite
Advance care planning (ACP) should be initiated early and be readdressed often for patients with cancer. This directive is expressed in the Institute of Medicine's report, "Dying in America," and is a component of several quality metrics, including ASCO's Quality Oncology Practice Initiative and the Centers for Medicare & Medicaid Services Oncology Care Model. Although simple in concept, implementation in practice is challenging. A variety of patient education tools exist in several different forms, including pamphlets, guidebooks, and question prompt lists, with the strongest data supporting the use of video decision aids that depict cardiopulmonary resuscitation...
June 6, 2017: Journal of Oncology Practice
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