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https://www.readbyqxmd.com/read/29054876/the-canonical-biotin-synthesis-enzyme-8-amino-7-oxononanoate-synthase-biof-utilizes-different-acyl-chain-donors-in-bacillus-subtilis-and-escherichia-coli
#1
Miglena Manandhar, John E Cronan
BioF (8-amino-7-oxononanoate synthase) is a strictly conserved enzyme that catalyzes the first step in assembly of the fused heterocyclic rings of biotin. The BioF acyl chain donor has long been thought to be pimeloyl-CoA. Indeed, in vitro the Escherichia coli and Bacillus sphaericus enzymes have been shown to condense pimeloyl-CoA with L-alanine in a pyridoxal 5' -phosphate-dependent reaction with concomitant CoA release and decarboxylation of L-alanine. However, recent in vivo studies of E. coli and Bacillus subtilis suggested that the BioF proteins of the two bacteria could have different specificities for pimelate thioesters in that E...
October 20, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29054754/structure-high-affinity-and-negative-cooperativity-of-the-escherichia-coli-holo-acyl-carrier-protein-holo-acyl-carrier-protein-synthase-complex
#2
Aaron M Marcella, Sannie J Culbertson, Michael A Shogren-Knaak, Adam W Barb
The Escherichia coli holo-(acyl carrier protein) synthase (ACPS) catalyzes the coenzyme A-dependent activation of apo-ACPP to generate holo-(acyl carrier protein) (holo-ACPP) in an early step of fatty acid biosynthesis. E. coli ACPS is sufficiently different from the human fatty acid synthase to justify the development of novel ACPS-targeting antibiotics. Models of E. coli ACPS in unliganded and holo-ACPP-bound forms solved by X-ray crystallography to 2.05Å and 4.10Å, respectively, revealed ACPS bound three product holo-ACPP molecules to form a 3:3 hexamer...
October 17, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29050283/omeprazole-promotes-carcinogenesis-of-fore-stomach-in-mice-with-co-stimulation-of-nitrosamine
#3
Lei Huang, Dong-Jiang Qi, Wei He, A-Man Xu
OBJECTIVES: To investigate if oral omeprazole application induces cancers of fore and glandular stomach in mice. METHODS: A total of 66 eligible male mice were randomly divided into 6 groups, which were treated with control reagent, low (6 mg/kg) and high dose omeprazole (30 mg/kg), N-methyl-N'-nitro-N-nitrosoguanidine (MNNG, 100 mg/L water), and MNNG plus low and high dose omeprazole, respectively. After 24 weeks, concentrations of acid phosphatase (ACP) and N-acetyl-β-D-glucosaminidase(NAG) in serum and spleen was examined, and p21 and mTOR levels in stomach were detected...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29045631/implementation-of-advance-care-planning-in-israel-a-convergence-of-top-down-and-bottom-up-processes
#4
Netta Bentur, Shelley Sternberg
Although public health has traditionally been concerned with primary, secondary, and tertiary prevention, more attention needs to be focused on patient-centered care at the end of life. Improved access to quality end-of-life care can be achieved by advance care planning (ACP). In this article, we present an example of the processes of change regarding ACP and preparing advance directives (ADs) that have begun to take place in Israel in recent years. We argue that these processes derive from the synergy between legislation on the one hand, and initiatives and action by health organizations on the other...
October 13, 2017: Gerontologist
https://www.readbyqxmd.com/read/29045609/stakeholder-perspectives-on-the-optimizing-patient-transfers-impacting-medical-quality-and-improving-symptoms-transforming-institutional-care-optimistic-project
#5
Mary Ersek, Susan E Hickman, Anne C Thomas, Brittany Bernard, Kathleen T Unroe, Suzanne Meeks
Background and Objectives: The need to reduce burdensome and costly hospitalizations of frail nursing home residents is well documented. The Optimizing Patient Transfers, Impacting Medical Quality, and Improving Symptoms: Transforming Institutional Care (OPTIMISTIC) project achieved this reduction through a multicomponent collaborative care model. We conducted an implementation-focused project evaluation to describe stakeholders' perspectives on (a) the most and least effective components of the intervention; (b) barriers to implementation; and (c) program features that promoted its adoption...
October 17, 2017: Gerontologist
https://www.readbyqxmd.com/read/29041464/down-conversion-rf-photonic-link-with-a-monolithically-integrated-acp-opll-phase-demodulator
#6
Longtao Xu, Shilei Jin, Yifei Li
We present a frequency down conversion RF/photonic link with an attenuation-counter-propagating optical phase lock loop (ACP-OPLL) photonic integrated circuit (PIC) receiver. Frequency down conversion was accomplished by nonlinear optical phase modulation in a 2.5mm long transmitter (TX) multi-quantum-well (MQW) phase modulator. The down-conversion link demonstrated RF to IF conversion loss of ~9dB and spurious free dynamic range (SFDR) of ~118dB∙Hz(2/3).
September 4, 2017: Optics Express
https://www.readbyqxmd.com/read/29034688/end-of-life-characteristics-and-palliative-care-provision-for-patients-with-motor-neuron-disease
#7
Hon Wai Benjamin Cheng, Oi Man Iman Chan, Chun Hung Red Chan, Wan Hung Chan, Koon Sim Fung, Kar Yin Wong
Motor neuron disease (MND) is a neurodegenerative disease and manifested as progressive decline in physical, respiratory, swallowing and communication function, and ultimately death. Traditional model of care was fragmented and did not match with multifacet needs of patients and carers. Furthermore, there could be lack of integrated care at end of life for patients with MND in most lower- and middle-income countries or in places with inadequate palliative care (PC) coverage. In view of this, a special workgroup for patients with MND, which includes neurologist, respiratory physician, rehabilitation specialist, and PC physician was formed in Hong Kong since year 2011...
January 1, 2017: American Journal of Hospice & Palliative Care
https://www.readbyqxmd.com/read/29033560/proactive-palliative-care-for-patients-with-copd-prolong-a-pragmatic-cluster-controlled-trial
#8
R G Duenk, C Verhagen, E M Bronkhorst, Pjwb van Mierlo, Meac Broeders, S M Collard, Pnr Dekhuijzen, Kcp Vissers, Y Heijdra, Y Engels
BACKGROUND AND AIM: Patients with advanced chronic obstructive pulmonary disease (COPD) have poor quality of life. The aim of this study was to assess the effects of proactive palliative care on the well-being of these patients. TRIAL REGISTRATION: This trial is registered with the Netherlands Trial Register, NTR4037. PATIENTS AND METHODS: A pragmatic cluster controlled trial (quasi-experimental design) was performed with hospitals as cluster (three intervention and three control) and a pretrial assessment was performed...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29032217/preoperative-prediction-of-the-necessity-for-anterior-clinoidectomy-during-microsurgical-clipping-of-ruptured-posterior-communicating-artery-aneurysms
#9
Tomoya Kamide, Jan-Karl Burkhardt, Halima Tabani, Michael Safaee, Michael T Lawton
BACKGROUND: Although most posterior communicating artery (PCoA) aneurysms can be clipped easily with excellent results, some require anterior clinoidectomy for safe and complete clipping. OBJECTIVE: To review our microsurgical series of ruptured PCoA aneurysms and identify the preoperative predictors for anterior clinoidectomy during microsurgical clipping for PCoA aneurysms METHODS: Results from microsurgical clipping of 104 patients with ruptured PCoA aneurysms were retrospectively reviewed...
October 11, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29025982/appropriate-use-criteria-for-somatostatin-receptor-pet-imaging-in-neuroendocrine-tumors
#10
Thomas A Hope, Emily Bergsland, Murat Fani Bozkurt, Michael M Graham, Anthony P Heaney, Ken Herrmann, James R Howe, Matthew H Kulke, Pamela L Kunz, Josh Mailman, Lawrence May, David C Metz, Corina Millo, Sue O'Dorisio, Diane L Reidy-Lagunes, Michael C Soulen, Jonathan R Strosberg
Somatostatin receptor positron emission tomography (SSTR-PET) is an imaging modality for patients with neuroendocrine tumors (NETs) that has demonstrated a significant improvement over conventional imaging (CI). SSTR-PET should replace In-111 pentetreotide scintigraphy (OctreoScan) in all indications in which SSTR scintigraphy is currently being used. These appropriate use criteria (AUC) are intended to aid referring medical practitioners in the appropriate use of SSTR-PET for imaging of patients with NETs, and the indications were evaluated in well-differentiated NETs...
October 12, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29023621/bond-strength-of-self-adhering-materials-effect-of-dentin-desensitizing-treatment-with-a-cpp-acp-paste
#11
Fereshteh Shafiei, Reza Derafshi, Mahtab Memarpour
This study investigated the effect of dentin-desensitizing treatment with a casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) paste on shear bond strength (SBS) of two types of self-adhering (SA) restorative materials: resin-modified glass-ionomer (Fuji II LC, GC) and self-adhering flowable composite resin (Vertise Flow, Kerr). Flat and smear layer-free dentin surfaces from 48 extracted molars were prepared and divided into four groups (n = 12 per group) according to Fuji II LC or Vertise Flow and CPP-ACP pretreatment or not...
November 2017: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/29023002/dynamics-of-huanglongbing-associated-bacterium-candidatus-liberibacter-asiaticus-in-citrus-aurantifolia-swingle-mexican-lime
#12
Jose Abel Lopez-Buenfil, Jose Abrahan Ramirez-Pool, Roberto Ruiz-Medrano, Maria Del Carmen Montes-Horcasitas, Claudio Chavarin-Palacio, Jesus Moya-Hinojosa, Francisco Javier Trujillo-Arriaga, Rosalia Lira Carmona, Beatriz Xoconostle-Cazares
BACKGROUND: The bacterial disease citrus huanglongbing (HLB), associated with "Candidatus Liberibacter asiaticus" (C.Las) has severely impacted the citrus industry, causing a significant reduction in production and fruit quality. In the present study, it was monitored the C.Las population dynamics in symptomatic, HLB-positive Mexican lime trees (Citrus aurantifolia Swingle) in a tropical, citrus-producing area of Mexico. The objective of this study was to identify the dynamics of the population of huanglongbing-associated bacterium Candidatus Liberibacter asiaticus and its insect vector in Citrus aurantifolia Swingle (Mexican lime)...
2017: Pakistan Journal of Biological Sciences: PJBS
https://www.readbyqxmd.com/read/29017021/chemical-composition-of-the-essential-oils-isolated-from-peel-of-three-citrus-species-and-their-mosquitocidal-activity-against-culex-pipiens
#13
Mohamed E I Badawy, Nehad E M Taktak, Ahmed F El-Aswad
Three essential oils (EOs) were isolated from the peel of citrus fruits Citrus reticulata L., Citrus reticulata chinase Blanco and Citrus sinensis (L.) Osbeck (Family: Rutaceae) and evaluated against Culex pipiens L.1758 (Family: Culicidae). Chemical composition indicated that the EOs were rich in essential phytochemicals including hydrocarbons, monoterpenes and sesquiterpenes. These constituents revealed some variability among the oils displaying interesting chemotypes limonene (35-51%), 1R-α-pinene (1.04-2...
October 10, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28993286/spirit-trial-a-phase-iii-pragmatic-trial-of-an-advance-care-planning-intervention-in-esrd
#14
Mi-Kyung Song, Mark L Unruh, Amita Manatunga, Laura C Plantinga, Janice Lea, Manisha Jhamb, Abhijit V Kshirsagar, Sandra E Ward
Advance care planning (ACP) is a central tenet of dialysis care, but the vast majority of dialysis patients report never engaging in ACP discussions with their care providers. Over the last decade, we have developed and iteratively tested SPIRIT (Sharing Patient's Illness Representation to Increase Trust), a theory-based, patient- and family-centered advance care planning intervention. SPIRIT is a six-step, two-session, face-to-face intervention to promote cognitive and emotional preparation for end-of-life decision making for patients with ESRD and their surrogates...
October 6, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28992715/-my-future-is-now-a-qualitative-study-of-persons-living-with-advanced-cancer
#15
Ann H Cottingham, Larry D Cripe, Kevin L Rand, Richard M Frankel
OBJECTIVES: Advance care planning (ACP) enables individuals to deliberate about future preferences for care based upon their values and beliefs about what is important in life. For many patients with advanced cancer, however, these critical conversations do not occur. A growing body of literature has examined the end-of-life wishes of seriously ill patients. Few studies have explored what is important to persons as they live with advanced cancer. The aim of the current study was to address this gap and to understand how clinicians can support patients' efforts to live in the present and plan for the future...
January 1, 2017: American Journal of Hospice & Palliative Care
https://www.readbyqxmd.com/read/28991437/structural-insight-into-acyl-acp-thioesterase-towards-substrate-specificity-design
#16
Yanbin Feng, Yayue Wang, Jiao Liu, Yinghui Liu, Xupeng Cao, Song Xue
Acyl-ACP thioesterase (TE) catalyzes the hydrolysis of thioester bonds during type II fatty acid synthesis and directly determines fatty acid chain length. Most TEs are responsible for recognition of 16:0 and 18:1 substrates, while specific TEs interrupt acyl-ACP elongation at C8-C14. However, the acyl selection mechanism of TE has not been thoroughly elucidated to date. In this study, the crystal structure of the C12-specific thioesterase FatB from Umbellularia californica, which consists of two independent hotdog domains, was determined...
October 9, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28989848/biomechanical-stability-of-a-stand-alone-interbody-spacer-in-two-level-and-hybrid-cervical-fusion-constructs
#17
Daniel G Kang, Scott C Wagner, Robert W Tracey, John P Cody, Rachel E Gaume, Ronald A Lehman
STUDY DESIGN: In vitro human cadaveric biomechanical analysis. OBJECTIVE: To evaluate the segmental stability of a stand-alone spacer (SAS) device compared with the traditional anterior cervical plate (ACP) construct in the setting of a 2-level cervical fusion construct or as a hybrid construct adjacent to a previous 1-level ACP construct. METHODS: Twelve human cadaveric cervical spines (C2-T1) were nondestructively tested with a custom 6-degree-of-freedom spine simulator under axial rotation (AR), flexion-extension (FE), and lateral bending (LB) at 1...
October 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28988561/discussing-advance-care-planning-insights-from-older-people-living-in-nursing-homes-and-from-family-members
#18
Francesca Ingravallo, Veronica Mignani, Elena Mariani, Giovanni Ottoboni, Marie Christine Melon, Rabih Chattat
BACKGROUND: Evidence concerning when and in which manner older people living in nursing homes (NHs) would prefer to discuss advance care planning (ACP) is still scarce. This study explored the attitudes of NH residents and family members toward ACP and their opinions as to the right time to broach the subject, the manner in which it should be approached, and the content of ACP. METHODS: This was a qualitative study using face-to-face interviews with 30 residents (age range 66-94), and 10 family members from 4 Italian NHs...
October 9, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28986226/internal-carotid-artery-and-its-relationship-with-structures-in-sellar-region-anatomy-study-and-its-clinical-applications
#19
Yishui Zhang, Wen Yang
BACKGROUND: Complications of the ICA in surgeries are rare but severe. This study aims to locate the ICA with 5 stationary bony structures in the sellar region: the anterior clinoid process (ACP), the tuberculum sellae, the bottom of the hypophyseal fossa, the posterior edge of the hypophyseal fossa and the post clinoid process and do measurements to determine their anatomic relationship with the ICA. METHODS: After multiple planar reconstructions on computer tomographic angiography images of 120 ICA in 60 individuals, we defined the 5 bony structures as 5 origins in horizontal, sagittal and vertical planes with the 3D coordinate system and got the cross-sections of bilateral ICA on the coronal plane passing through each origin...
October 3, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28984614/progression-of-duchenne-cardiomyopathy-presenting-with-chest-pain-and-troponin-elevation
#20
Kan N Hor, Pace Johnston, Kathi Kinnett, May Ling Mah, Corey Stiver, Larry Markham, Linda Cripe
BACKGROUND: Improved neuromuscular and respiratory therapies have altered the natural history of Duchenne muscular dystrophy (DMD) such that the most common cause of mortality is progressive cardiomyopathy. Despite imaging evidence of progressive cardiomyopathy, troponin I (cTn) is not significantly elevated in asymptomatic DMD patients. RESULTS: We describe eight boys with DMD evaluated for acute chest pain (ACP) and found to have acute cTn elevation with depressed left ventricular ejection fraction (LVEF)...
October 5, 2017: Journal of Neuromuscular Diseases
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