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https://www.readbyqxmd.com/read/28716615/development-of-a-protocol-for-successful-palliative-care-consultation-in-population-of-patients-receiving-mechanical-circulatory-support
#1
Shilpee Sinha, Carey Belcher, Alexia Torke, Joycelyn Howard, Marco Caccamo, James A Slaven, Irmina Gradus-Pizlo
BACKGROUND: In 2014, Joint Commission recommended palliative care (PC) engagement in ventricular assist device (VAD) implantation as destination therapy. Limited information is available on established PC protocols in the mechanical circulatory support (MCS) population. MEASURES: The goals of our PC consultation were to document advance care planning (ACP) discussions and designate a surrogate decision maker (SDM) prior to MCS implantation. A retrospective analysis compared the frequency of PC consults, ACP discussion, and SDM before and after protocol implementation...
July 14, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28715001/structural-evidence-for-the-covalent-modification-of-fabh-by-4-5-dichloro-1-2-dithiol-3-one-hr45
#2
Alexander G Ekström, Van Kelly, Jon Marles-Wright, Scott L Cockroft, Dominic J Campopiano
We use mass spectrometry analysis and molecular modelling to show the established antimicrobial inhibitor 4,5-dichloro-1,2-dithiol-3-one (HR45) acts by forming a covalent adduct with the target β-ketoacyl-ACP synthase III (FabH). The 5-chloro substituent directs attack of the essential active site thiol (C112) via a Michael-type addition elimination reaction mechanism.
July 17, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28714907/genetic-contribution-to-alcohol-dependence-investigation-of-a-heterogeneous-german-sample-of-individuals-with-alcohol-dependence-chronic-alcoholic-pancreatitis-and-alcohol-related-cirrhosis
#3
Jens Treutlein, Josef Frank, Fabian Streit, Céline S Reinbold, Dilafruz Juraeva, Franziska Degenhardt, Liz Rietschel, Stephanie H Witt, Andreas J Forstner, Monika Ridinger, Jana Strohmaier, Norbert Wodarz, Helene Dukal, Jerome C Foo, Per Hoffmann, Stefan Herms, Stefanie Heilmann-Heimbach, Michael Soyka, Wolfgang Maier, Wolfgang Gaebel, Norbert Dahmen, Norbert Scherbaum, Bertram Müller-Myhsok, Susanne Lucae, Marcus Ising, Felix Stickel, Thomas Berg, Ulla Roggenbuck, Karl-Heinz Jöckel, Henrike Scholz, Ulrich S Zimmermann, Stephan Buch, Wolfgang H Sommer, Rainer Spanagel, Benedikt Brors, Sven Cichon, Karl Mann, Falk Kiefer, Jochen Hampe, Jonas Rosendahl, Markus M Nöthen, Marcella Rietschel
The present study investigated the genetic contribution to alcohol dependence (AD) using genome-wide association data from three German samples. These comprised patients with: (i) AD; (ii) chronic alcoholic pancreatitis (ACP); and (iii) alcohol-related liver cirrhosis (ALC). Single marker, gene-based, and pathway analyses were conducted. A significant association was detected for the ADH1B locus in a gene-based approach (puncorrected = 1.2 × 10(-6); pcorrected = 0.020). This was driven by the AD subsample...
July 17, 2017: Genes
https://www.readbyqxmd.com/read/28713112/effect-of-casein-phosphopeptide-amorphous-calcium-phosphate-and-three-calcium-phosphate-on-enamel-microhardness
#4
En Hr Haghgou, Roza Haghgoo, Mohamad R Roholahi, Zahra Ghorbani
AIM: This study aims to investigate the effect of casein phos-phopeptide-amorphous calcium phosphate and three calcium phosphate (CPP-ACP and TCP) on increasing the microhardness of human enamel after induction of erosion. MATERIALS AND METHODS: A total of 26 healthy human-impacted third molar teeth were chosen, and their hardness measured using a microhardness testing machine. The samples were immersed in Coca Cola (pH = 4.7) for 8 minutes. Then, micro-hardness was measured again, and these samples were randomly divided into four groups (two control groups and two experimental groups)...
July 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28708339/-advance-directives-and-advance-care-planning
#5
Petra Vayne-Bossert, Christiane Vailloud, Dominique Ducloux, Caroline Matis, Laurence Déramé
Advance directives (AD) and Advance Care Planning (ACP) are two measures a person may undertake to assure that their treatment preferences will be respected until the end of his / her life. Anticipation is based on an open and honest communication between the patient, the durable medical power of attorney and the health care professionals. ADs and ACPs are based on a person's values and beliefs that are important to his quality of life. ACP is a continuing process, initiated by health care professionals and integrated into the health care plan of a person...
February 1, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28707994/do-craniopharyngioma-molecular-signatures-correlate-with-clinical-characteristics
#6
Sacit Bulent Omay, Yu-Ning Chen, Joao Paulo Almeida, Armando Saul Ruiz-Treviño, John A Boockvar, Philip E Stieg, Jeffrey P Greenfield, Mark M Souweidane, Ashutosh Kacker, David J Pisapia, Vijay K Anand, Theodore H Schwartz
OBJECTIVE Exome sequencing studies have recently demonstrated that papillary craniopharyngiomas (PCPs) and adamantinomatous craniopharyngiomas (ACPs) have distinct genetic origins, each primarily driven by mutually exclusive alterations: either BRAF ( V600E), observed in 95% of PCPs, or CTNNB1, observed in 75%-96% of ACPs. How the presence of these molecular signatures, or their absence, correlates with clinical, radiographic, and outcome variables is unknown. METHODS The pathology records for patients who underwent surgery for craniopharyngiomas between May 2000 and March 2015 at Weill Cornell Medical College were reviewed...
July 14, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28706493/protein-phosphorylation-and-mineral-binding-affect-the-secondary-structure-of-the-leucine-rich-amelogenin-peptide
#7
Hajime Yamazaki, Elia Beniash, Yasuo Yamakoshi, James P Simmer, Henry C Margolis
Previously, we have shown that serine-16 phosphorylation in native full-length porcine amelogenin (P173) and the Leucine-Rich Amelogenin Peptide (LRAP(+P)), an alternative amelogenin splice product, affects protein assembly and mineralization in vitro. Notably, P173 and LRAP(+P) stabilize amorphous calcium phosphate (ACP) and inhibit hydroxyapatite (HA) formation, while non-phosphorylated counterparts (rP172, LRAP(-P)) guide the growth of ordered bundles of HA crystals. Based on these findings, we hypothesize that the phosphorylation of full-length amelogenin and LRAP induces conformational changes that critically affect its capacity to interact with forming calcium phosphate mineral phases...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28705009/palliative-care-and-advance-care-planning-for-pancreas-and-other-cancers
#8
Rajiv Agarwal, Andrew S Epstein
The principles of palliative care are fundamental to support and treat the physical, mental, and psychosocial health of patients living with pancreatic cancer. In addition to its proven advantages to help manage disease-related symptoms, improve accurate illness understanding, and enhance the quality of life and survival outcomes for patients with advanced disease, the inclusion of palliative care principles (whether by a specialist or by the primary oncology team) with standard oncologic care strengthens timely and quality advance care planning (ACP)...
June 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28702672/chitosan-stabilized-platinum-nanoparticles-as-effective-oxidase-mimics-for-colorimetric-detection-of-acid-phosphatase
#9
Hao-Hua Deng, Xiu-Ling Lin, Yin-Huan Liu, Ke-Lin Li, Qiong-Qiong Zhuang, Hua-Ping Peng, Ai-Lin Liu, Xing-Hua Xia, Wei Chen
Capping molecules on the surface of nanomaterials not only enhance the dispersion and stability of nanomaterials but also greatly facilitate their surface modification and biological applications. However, most capping molecules can severely block the active sites of the catalytic core, thereby decreasing the enzymatic activity of nanomaterial-based enzyme mimics. This work demonstrates the superiority of chitosan (Ch) as a capping molecule for synthesizing catalytic platinum nanoparticles (PtNPs). The experimental results show that Ch simultaneously exhibits an excellent stabilizing effect and enhances the oxidase-like activity of PtNPs...
July 12, 2017: Nanoscale
https://www.readbyqxmd.com/read/28701843/incidence-proportion-of-acute-cor-pulmonale-in-patients-with-acute-respiratory-distress-syndrome-subjected-to-lung-protective-ventilation-a-systematic-review-and-meta-analysis
#10
Saurabh Kumar Das, Nang Sujali Choupoo, Priyam Saikia, Amitabh Lahkar
INTRODUCTION: Reported incidence of acute cor pulmonale (ACP) in patients with acute respiratory distress syndrome (ARDS) varies from 10% to 84%, despite being subjected to lung protective ventilation according to the current guidelines. The objective of this review is to find pooled cumulative incidence of ACP in patients with ARDS undergoing lung protective ventilation. MATERIALS AND METHODS: We searched MEDLINE, EMBASE, Cochrane Library, KoreaMed, LILACS, and WHO Clinical Trial Registry...
June 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28699722/antinociceptive-anti-inflammatory-and-antiarthritic-activities-of-bungarus-fasciatus-venom-in-experimental-animal-models
#11
Susmita Ghosh, Partha Pratim Saha, Subir C Dasgupta, Antony Gomes
Pain and inflammation are intimately associated with rheumatoid arthritis, a growing bone-joint related problem of the modern society. Though several therapeutic managements are available for arthritis, their side effects not only limit their use, but also advocate the quest for natural therapies. In this study, we explored the antinociceptive, anti-inflammatory and antiarthritic activities of Bungarus fasciatus venom (BFV) in experimental animal models. Rheumatoid arthritis was induced by Freund’s complete adjuvant (FCA) in male Wistar albino rats...
September 2016: Indian Journal of Experimental Biology
https://www.readbyqxmd.com/read/28698127/dietary-protein-levels-regulated-antibacterial-activity-inflammatory-response-and-structural-integrity-in-the-head-kidney-spleen-and-skin-of-grass-carp-ctenopharyngodon-idella-after-challenged-with-aeromonas-hydrophila
#12
Wei-Dan Jiang, Jing Xu, Xiao-Qiu Zhou, Pei Wu, Yang Liu, Jun Jiang, Sheng-Yao Kuang, Ling Tang, Wu-Neng Tang, Yong-An Zhang, Lin Feng
This study investigated the effects of dietary protein levels on disease resistance, immune function and structural integrity in the head kidney, spleen and skin of grass carp (Ctenopharyngodon idella). A total of 540 grass carp (264.11 ± 0.76 g) were fed six diets containing graded levels of protein (143.1, 176.7, 217.2, 257.5, 292.2 and 322.8 g digestible protein kg(-1) diet) for 8 weeks. After the growth trial, fish were challenged with Aeromonas hydrophila for 14 days. The results indicated that optimal levels of dietary protein: (1) (1) increased the lysozyme (LA) and acid phosphatase (ACP) activities and the complement 3 (C3) and C4 contents, up-regulated antimicrobial peptides, anti-inflammatory cytokines, inhibitor of κBα, target of rapamycin and ribosomal protein S6 kinases 1 mRNA levels, whereas down-regulated pro-inflammatory cytokines, nuclear factor kappa B (NF-κB) P65, IKKβ, IKKγ, eIF4E-binding proteins (4E-BP) 1 and 4E-BP2 mRNA levels in the head kidney, spleen and skin of grass carp (P < 0...
July 8, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28693951/gene-silencing-of-stearoyl-acp-desaturase-enhances-the-stearic-acid-content-in-chlamydomonas-reinhardtii
#13
L de Jaeger, J Springer, E J H Wolbert, D E Martens, G Eggink, R H Wijffels
In this study, stearoyl-ACP desaturase (SAD), the enzyme that converts stearic acid into oleic acid, is silenced by artificial microRNA in the green microalga Chlamydomonas reinhardtii. Two different constructs, which target different positions on the mRNA of stearoyl-ACP desaturase, were tested. The mRNA levels for SAD were reduced after the silencing construct was induced. In one of the strains, the reduction in SAD mRNA resulted in a doubling of the stearic acid content in triacylglycerol molecules, which shows that stearic acid production in microalgae is possible...
June 30, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28693654/cut-and-rip-and-cut-alone-techniques-versus-usual-practice-in-the-removal-of-trauma-patient-clothing
#14
Aaron K Sibley, Trevor N Jain, Brent Nicholson, Paul Atkinson
Introduction Rapid exposure of a trauma patient is an essential component of the primary survey. No gold standard exists regarding the best technique to remove clothing from a trauma patient. The purpose of this study is to compare two techniques of clothing removal versus usual practice using standard trauma shears. METHODS: Advanced Care Paramedic (ACP) students were randomized to either the Cut and Rip (CAR) or Cut Alone (CAL) techniques to remove clothing from a standardized trauma mannequin...
July 11, 2017: CJEM
https://www.readbyqxmd.com/read/28691154/digestive-enzyme-ratios-are-good-indicators-of-hatchling-yolk-reserve-and-digestive-gland-maturation-in-early-life-stages-of-cuttlefish-sepia-officinalis-l-application-of-these-new-tools-in-ecology-and-aquaculture
#15
Georges Safi, A S Martinez, C Le Pabic, E Le Bihan, J P Robin, N Koueta
In Sepia officinalis (Linnaeus, 1758), the digestive gland matures during the first month post-hatching, while a shift from intracellular acid to extracellular alkaline digestion occurs. The purpose of this study was to investigate the possibility of using enzymatic ratios for the description of digestive system maturation in early life stages of S. officinalis. Second, it is intended to apply these new tools as eco-physiological indicators for understanding the impact of cuttlefish eggs' life history from different spawning sites of the English Channel on digestive performance of juveniles...
July 10, 2017: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/28690009/amorphous-surface-layer-versus-transient-amorphous-precursor-phase-in-bone-a-case-study-investigated-by-solid-state-nmr-spectroscopy
#16
Stanislas Von Euw, Widad Ajili, Tsou-Hsi-Camille Chan-Chang, Annette Delices, Guillaume Laurent, Florence Babonneau, Nadine Nassif, Thierry Azaïs
The presence of an amorphous surface layer that coats a crystalline core has been proposed for many biominerals, including bone mineral. In parallel, transient amorphous precursor phases have been proposed in various biomineralization processes, including bone biomineralization. Here we propose a methodology to investigate the origin of these amorphous environments taking the bone tissue as a key example. This study relies on the investigation of a bone tissue sample and its comparison with synthetic calcium phosphate samples, including a stoichiometric apatite, an amorphous calcium phosphate sample, and two different biomimetic apatites...
July 6, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28689366/micro-ct-and-fe-sem-enamel-analyses-of-calcium-based-agent-application-after-bleaching
#17
Mauricio Neves Gomes, Flávia Pires Rodrigues, Nick Silikas, Carlos Eduardo Francci
OBJECTIVES: The objective of the present study is to evaluate the effects of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) on bleached enamel. MATERIALS AND METHODS: A bleaching agent (35% hydrogen peroxide) was applied, 4 × 8 min on premolar teeth (n = 8). A CPP-ACP paste was applied for 7 days. Prior and post-treatment, microtomography images were obtained and 3D regions of interest (ROIs) were selected, from outer enamel, extending to 110...
July 8, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28687135/advance-care-planning-within-survivorship-care-plans-for-older-cancer-survivors-a-systematic-review
#18
REVIEW
Rónán O'Caoimh, Nicola Cornally, Ronan O'Sullivan, Ruth Hally, Elizabeth Weathers, Amanda H Lavan, Tara Kearns, Alice Coffey, Ciara McGlade, D William Molloy
Advances in the medical treatment of cancer have increased the number of survivors, particularly among older adults, who now represent the majority of these. Survivorship care plans (SCPs) are documents that cancer patients receive summarising their care, usually at the end of treatment but preferably from initial diagnosis. These may increase patient satisfaction and represent an opportunity to initiate preventative strategies and address future care needs. Advance care planning (ACP), incorporating advance healthcare decision-making, including formal written directives, increases satisfaction and end-of-life care...
June 23, 2017: Maturitas
https://www.readbyqxmd.com/read/28684840/prevention-of-secondary-caries-using-silver-diamine-fluoride-treatment-and-casein-phosphopeptide-amorphous-calcium-phosphate-modified-glass-ionomer-cement
#19
(no author information available yet)
Treatment of the cavity with silver diamine fluoride before placement of glass ionomer cement containing CPP-ACP enhances anticariogenic effect in vitro.
July 7, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28684702/phytosterols-from-dunaliella-tertiolecta-reduce-cell-proliferation-in-sheep-fed-flaxseed-during-post-partum
#20
Maria Giovanna Ciliberti, Matteo Francavilla, Simona Intini, Marzia Albenzio, Rosaria Marino, Antonella Santillo, Mariangela Caroprese
The post partum period is characterized by immunosuppression and increased disease susceptibility. Both phytosterols from microalga Dunaniella tertiolecta and dietary supplementation with n-3 polyunsaturated fatty acids (PUFA) influence cell proliferation and cytokine release during inflammation. The objective of this paper was the evaluation of the effects of physterols, extracted and purified from D. tertiolecta, on the in vitro immune responses of ewes supplemented with flaxseed during post partum. Twenty Comisana parturient ewes were divided in two balanced groups, and supplemented with flaxseed (FS, 250 g/day) or fed with a conventional diet (CON)...
July 6, 2017: Marine Drugs
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