keyword
https://read.qxmd.com/read/38492731/predicting-30-day-mortality-after-ruptured-abdominal-aortic-aneurysms-validation-of-the-harborview-risk-score-in-a-single-center-dutch-study-population
#21
JOURNAL ARTICLE
Shanti-Devi Maria Khargi, Annemijne Nelle Nelissen, Arvind Oemrawsingh, Hugo Thomas Christian Veger, Jan J Wever, Jeroen Johannes Wilhelmus Maria Brouwers, Randolph George Statius van Eps
OBJECTIVE: The Harborview Risk Score (HRS) was recently proposed as scoring tool to predict 30-day mortality in patients with ruptured abdominal aortic aneurysms (rAAA). The HRS assigns one point for each of the following preoperative characteristics: age >76 years, pH <7.2, creatinine level >2mg/dL (>176.8 μmol/L) and systolic blood pressure <70mmHg, resulting in scores from 0 to 4. The 30-day mortality risk increases with every point. Primarily, we aimed to validate the HRS for the first time in a Dutch study population...
March 14, 2024: Annals of Vascular Surgery
https://read.qxmd.com/read/38492689/identification-and-characterization-of-chitinase-producing-marine-microorganism-unleashing-the-potential-of-chitooligosaccharides-for-bioethanol-synthesis
#22
JOURNAL ARTICLE
P V Atheena, K M Rajesh, Keyur Raval, Subbalaxmi Selvaraj, Ritu Raval
The dwindling supply of the petroleum product and its carbon footprint has initiated search for a sustainable fuel and alternate feed-stocks. One such underexplored feedstock is chitin, a waste derived from sea food processing. The limitation of insolubility and crystallinity inherent in chitin is addressed with the chitin hydrolysates. In the present study, a chitinases producing marine isolate was isolated from the sediments of Arabian Sea from a depth of 20 m. In order to increase the expression of the chitinases, sequential optimisation using one factor at a time and Taguchi experimental designs were employed which resulted in a yield of 13...
March 14, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38492669/microrna-regulation-of-islet-and-enteroendocrine-peptides-physiology-and-therapeutic-implications-for-type-2-diabetes
#23
JOURNAL ARTICLE
E R Carr, P B Higgins, N H McClenaghan, P R Flatt, A G McCloskey
The pathogenesis of type 2 diabetes (T2D) is associated with dysregulation of glucoregulatory hormones, including both islet and enteroendocrine peptides. Microribonucleic acids (miRNAs) are short noncoding RNA sequences which post transcriptionally inhibit protein synthesis by binding to complementary messenger RNA (mRNA). Essential for normal cell activities, including proliferation and apoptosis, dysregulation of these noncoding RNA molecules have been linked to several diseases, including diabetes, where alterations in miRNA expression within pancreatic islets have been observed...
March 14, 2024: Peptides
https://read.qxmd.com/read/38492538/influence-of-copper-source-and-dietary-inclusion-level-on-growth-performance-of-weaned-pigs-and-expression-of-trace-element-related-genes-in-the-small-intestine
#24
JOURNAL ARTICLE
J van Baal, L Kruijt, G P Binnendijk, S Durosoy, A Romeo, P Bikker
Copper is routinely supplemented to weanling pig diets at concentrations above nutritional requirements to enhance growth performance. We hypothesised that this effect depends on the source of Cu and its dietary concentration. We tested this in weaned pigs (26 d of age) over a 35-d period using a 2 × 3 factorial arrangement with two Cu-sources (CuSO4 and Cu2 O, monovalent copper oxide, CoRouge®) and three supplementary dietary Cu-levels (15, 80 and 160 mg Cu/kg) as respective factors...
February 15, 2024: Animal
https://read.qxmd.com/read/38492537/human-in-the-loop-optimization-of-rocker-shoes-via-different-cost-functions-during-walking
#25
JOURNAL ARTICLE
Thijs Tankink, Juha M Hijmans, Raffaella Carloni, Han Houdijk
Personalised footwear could be used to enhance the function of the foot-ankle complex to a person's maximum. Human-in-the-loop optimization could be used as an effective and efficient way to find a personalised optimal rocker profile (i.e., apex position and angle). The outcome of this process likely depends on the selected optimization objective and its responsiveness to the rocker parameters being tuned. This study aims to explore whether and how human-in-the-loop optimization via different cost functions (i...
February 28, 2024: Journal of Biomechanics
https://read.qxmd.com/read/38492520/inhibition-of-pedv-viral-entry-upon-blocking-n-glycan-elaboration
#26
JOURNAL ARTICLE
Yong Zhao, Tao Tang, Wenchang Zhao, Weiguang Fu, Tao Li
Porcine Epidemic Diarrhea Virus (PEDV) poses a significant threat to the global swine industry, demanding a thorough understanding of its cellular invasion mechanism for effective interventions. This study meticulously investigates the impact of O- and N-linked glycans on PEDV proteins and host cell interaction, shedding light on their influence on the virus's invasion process. Utilizing CRISPR-Cas9 technology to inhibit cell surface O- and N-linked glycan synthesis demonstrated no discernible impact on virus infection...
March 12, 2024: Virology
https://read.qxmd.com/read/38492478/mechanism-of-organic-phosphorus-transformation-and-its-impact-on-the-primary-production-in-a-deep-oligotrophic-plateau-lake-during-stratification
#27
JOURNAL ARTICLE
Xiaotong Han, Fan Xun, Xianlong Zhu, Cheng Zhao, Wenlei Luo, Yanru Liu, Man Wang, Di Xu, Shiqiang Wan, Qinglong L Wu, Peng Xing
Global warming is leading to extended stratification in deep lakes, which may exacerbate phosphorus (P) limitation in the upper waters. Conversion of labile dissolved organic P (DOP) is a possible adaptive strategy to maintain primary production. To test this, the spatiotemporal distributions of various soluble P fractions and phosphomonesterase (PME)/phosphodiesterase (PDE) activities were investigated in Lake Fuxian during the stratification period and the transition capacity of organic P and its impact on primary productivity were evaluated...
March 7, 2024: Water Research
https://read.qxmd.com/read/38492423/beach-wrack-discussing-ecological-roles-risks-and-sustainable-bioenergy-and-agricultural-applications
#28
REVIEW
Maria Martins, Filipa Sousa, Cristiano Soares, Bruno Sousa, Ruth Pereira, Marcos Rubal, Fernanda Fidalgo
The equilibrium of the marine ecosystem is currently threatened by several constraints, among which climate change and anthropogenic activities stand out. Indeed, these factors favour the growth of macroalgae, which sometimes end up stranded on the beaches at the end of their life cycle, forming what is known as beach wrack. Despite its undeniable important ecological role on beaches, as it is an important source of organic matter (OM), and provides food and habitat for several invertebrates, reptiles, small mammals, and shorebirds, the overaccumulation of beach wrack is often associated with the release of greenhouse gases, negatively impacting tourist activities, and generating economic expenses for its removal...
March 15, 2024: Journal of Environmental Management
https://read.qxmd.com/read/38492413/eudragit-s100-coated-nanodiamond-based-nanoparticles-as-an-oral-chemo-photothermal-delivery-system-for-local-treatment-of-colon-cancer
#29
JOURNAL ARTICLE
Yupei Su, Hao Pan, Jiahui Wang, Dandan Liu, Weisan Pan
Oral colonic nano-drug delivery system has received more and more attention in the treatment of colon cancer due to local precision treatment and reduction of drug system distribution. However, the complex and harsh gastrointestinal environment and the retention of nanoparticles in the colon limit its development. To this end, we designed Eudragit S100 (ES) coated nanoparticles (ES@PND-PEG-TPP/DOX). Polydopamine coated nanodiamond (PND) was modified with amino-functionalized polyethylene glycol (NH2 -PEG-NH2 ) and triphenylphosphine (TPP) successively...
March 13, 2024: Colloids and Surfaces. B, Biointerfaces
https://read.qxmd.com/read/38492388/ratiometric-fluoroprobe-based-on-eu-mof-tb-3-for-detecting-tetracycline-hydrochloride-in-freshwater-fish-and-its-application-in-rapid-visual-detection
#30
JOURNAL ARTICLE
Longtian Chen, Zhongjie Li, Yuemao Dou, Huili Wang, Chunyang Chen, Xuedong Wang
Tetracycline hydrochloride (TCH), a prevalent antibiotic in aquaculture for treating bacterial infections, poses challenges for on-site detection. This study employed the reversed-phase microemulsion method to synthesize a uniform nano metal-organic framework (MOF) material, europium-benzene-p-dicarboxylic acid (Eu-BDC), doped with Tb3+ to form a dual-emission fluorescence probe. By leveraging the combined a-photoinduced electron-transfer (a-PET) and inner filter effect (IFE) mechanisms, high-sensitivity TCH detection in Carassius auratus and Ruditapes philippinarum was achieved...
March 14, 2024: Journal of Hazardous Materials
https://read.qxmd.com/read/38492383/boosting-the-reversibility-of-zn-anodes-via-synergistic-cation-anion-interface-adsorption-with-addition-of-multifunctional-potassium-polyacrylate
#31
JOURNAL ARTICLE
Kang Zhao, Jinhu Sheng, Nairui Luo, Junwei Ding, Hewei Luo, Xiaodong Jia, Shiwen Wang, Shaoming Fang
Rechargeable aqueous Zn batteries have the edge in resource reserve, cost, energy and conversion efficiency due to the inherent features of metal Zn anodes. However, the application of Zn-based batteries is being seriously hindered by Zn dendrites and water-induced side-reactions. Here, potassium polyacrylate (K-PAM) is proposed as the electrolyte additive to form a synergistic cation-anion interface on Zn surface. The carboxyl anions and K+ cations are preferentially adsorbed on the Zn surface due to the intrinsic surfactant characteristics, which could homogenize Zn plating and suppress parasitic reactions...
March 11, 2024: Journal of Colloid and Interface Science
https://read.qxmd.com/read/38492369/resolution-of-the-reciprocity-between-radical-species-from-precursor-and-closed-pore-formation-in-hard-carbon-for-sodium-storage
#32
JOURNAL ARTICLE
Bin Wang, Yazhen Yao, Wanli Wang, Yujie Xu, Yi Wan, Yi Sun, Qiang Li, Han Hu, Mingbo Wu
Hard carbon (HC) has emerged as a highly promising anode material for sodium ion batteries, drawing tremendous interest in producing this material with low-cost and easily accessible precursors. The determination of the crucial parameters of precursors influencing the formation of key structures, such as closed pores, in the HC is of paramount importance. Considering the potential role of free radicals in the structural evolution of the precursors, we, for the first time, delve into the impact of radical species on the development of closed pores by electron paramagnetic resonance spectroscopy, with petroleum asphalt as the model system...
March 11, 2024: Journal of Colloid and Interface Science
https://read.qxmd.com/read/38492231/co-design-of-an-intervention-to-improve-patient-participation-in-discharge-medication-communication
#33
JOURNAL ARTICLE
Georgia Tobiano, Sharon Latimer, Elizabeth Manias, Andrea P Marshall, Megan Rattray, Kim Jenkinson, Trudy Teasdale, Kellie Wren, Wendy Chaboyer
Patients can experience medication-related harm and hospital readmission because they do not understand or adhere to post-hospital medication instructions. Increasing patient medication literacy and, in turn, participation in medication conversations could be a solution. The purposes of this study were to co-design and test an intervention to enhance patient participation in hospital discharge medication communication. In terms of methods, co-design, a collaborative approach where stakeholders design solutions to problems, was used to develop a prototype medication communication intervention...
March 16, 2024: International Journal for Quality in Health Care
https://read.qxmd.com/read/38492212/monitoring-of-sprint-and-change-of-direction-velocity-vertical-jump-height-and-repeated-sprint-ability-in-sub-elite-female-football-players-throughout-their-menstrual-cycle
#34
JOURNAL ARTICLE
P H Igonin, F Cognasse, P Gonzalo, P Philippot, I Rogowski, T Sabot, N Boisseau, C Martin
AIMS: The aim of this study was to investigate the associations between the early follicular (EF, i.e., menstruation), late follicular (LF), and middle luteal (ML) phases of the menstrual cycle and different factors that may influence football performance. METHODS: To this end, 11 eumenorrheic sub-elite female football players underwent field tests to assess sprint speed, lower extremity power, repeated sprint ability, velocity on change of direction, and technical skills at each cycle phase...
March 16, 2024: Science & medicine in football
https://read.qxmd.com/read/38492182/environmental-enrichment-reverses-proulcerogenic-action-of-social-isolation-on-the-gastric-mucosa-and-positively-influences-pain-sensitivity-and-work-capacity
#35
REVIEW
Ludmila P Filaretova, Olga P Komkova, Olga Yu Morozova, Polina V Punina, Natalia I Yarushkina
The aim of the study was to investigate the effects of rat housing conditions-standard conditions, social isolation, environmental enrichment-and the subsequent reversal of these conditions on the vulnerability of the gastric mucosa to ulcerogenic stimuli, somatic pain sensitivity, and treadmill work capacity. Rats, aged 30 days, were placed in standard conditions (SC), social isolation (Is), and environmental enrichment (EE) for 4 weeks. Then half of each group underwent a reversal of housing conditions: SC rats were moved to Is, Is rats were placed in EE, EE rats were moved to Is, for 2 weeks...
March 16, 2024: Inflammopharmacology
https://read.qxmd.com/read/38492067/short-term-outcomes-of-robot-assisted-versus-conventional-minimally-invasive-esophagectomy-for-esophageal-cancer-a-systematic-review-and-meta-analysis-of-18-187-patients
#36
REVIEW
Rui Perry, José Pedro Barbosa, Isabel Perry, José Barbosa
The role of robotic surgery in the curative-intent treatment of esophageal cancer patients is yet to be defined. To compare short-term outcomes between conventional minimally invasive (cMIE) and robot-assisted minimally invasive esophagectomy (RAMIE) in esophageal cancer patients. PubMed, Web of Science and Cochrane Library were systematically searched. The included studies compared short-term outcomes between cMIE and RAMIE. Individual risk of bias was calculated using the MINORS and RoB2 scales. There were no statistically significant differences between RAMIE and cMIE regarding conversion to open procedure, mean number of harvested lymph nodes in the mediastinum, abdomen and along the right recurrent laryngeal nerve (RLN), 30- and 90-day mortality rates, chyle leakage, RLN palsy as well as cardiac and infectious complication rates...
March 16, 2024: Journal of Robotic Surgery
https://read.qxmd.com/read/38492064/clinical-outcomes-of-patellofemoral-arthroplasty-robotic-assistance-produces-superior-short-and-mid-term-outcomes
#37
JOURNAL ARTICLE
Jonathan L Katzman, Weston Buehring, Muhammad A Haider, Patrick Connolly, Ran Schwarzkopf, Ivan Fernandez-Madrid
INTRODUCTION: Patellofemoral arthroplasty (PFA) has been shown to provide symptomatic improvement for isolated patellofemoral osteoarthritis (PFOA). The efficacy of robotic-assisted PFA and the most suitable PFA implant design, however, remain ongoing matters of debate. This study sought to compare clinical outcomes between patients who underwent robotic-assisted versus conventional PFAs with inlay and onlay prosthetic designs. METHODS: A single-center retrospective review found 237 knees (211 patients) which underwent PFA between 2011 and 2021...
March 16, 2024: Archives of Orthopaedic and Trauma Surgery
https://read.qxmd.com/read/38492006/a-dynamic-model-of-growth-phase-of-bio-conversion-of-methane-to-polyhydroxybutyrate-using-dynamic-flux-balance-analysis
#38
JOURNAL ARTICLE
Mohadeseh Nasershariat, Mahmoud Reza Pishvaie, Ramin Bozorgmehry Boozarjomehry, Steffen Waldherr
Biological conversion of waste methane to biodegradable plastics is a way of reducing their production cost. This study addresses the computational modeling of the growth phase reactor of the process of polyhydroxybutyrate production. The model was used for investigating the effect of gas recycling and inlet gas retention time on the reactor performance. The model was run by the use of a genome-scale metabolic network of Methylocystis hirsuta in a dynamic flux balance analysis framework. The reactor has been modeled for two separate feeding scenarios: a pure methane feed and a biogas feed...
March 16, 2024: Bioprocess and Biosystems Engineering
https://read.qxmd.com/read/38491985/an-efficient-genetic-transformation-system-mediated-by-rhizobium-rhizogenes-in-fruit-trees-based-on-the-transgenic-hairy-root-to-shoot-conversion
#39
JOURNAL ARTICLE
Lin Liu, Jinghua Qu, Chunyan Wang, Miao Liu, Chunmeng Zhang, Xinyue Zhang, Cheng Guo, Changai Wu, Guodong Yang, Jinguang Huang, Kang Yan, Huairui Shu, Chengchao Zheng, Shizhong Zhang
Genetic transformation is a critical tool for gene editing and genetic improvement of plants. Although many model plants and crops can be genetically manipulated, genetic transformation systems for fruit trees are either lacking or perform poorly. We used Rhizobium rhizogenes to transfer the target gene into the hairy roots of Malus domestica and Actinidia chinensis. Transgenic roots were generated within 3 weeks, with a transgenic efficiency of 78.8%. Root to shoot conversion of transgenic hairy roots was achieved within 11 weeks, with a regeneration efficiency of 3...
March 16, 2024: Plant Biotechnology Journal
https://read.qxmd.com/read/38491922/new-insights-into-patterns-of-integration-in-the-femur-and-pelvis-among-catarrhines
#40
JOURNAL ARTICLE
Quentin Cosnefroy, Gilles Berillon, Emmanuel Gilissen, Pauline Brige, Kathia Chaumoître, Franck Lamberton, François Marchal
OBJECTIVES: Integration reflects the level of coordinated variation of the phenotype. The integration of postcranial elements can be studied from a functional perspective, especially with regards to locomotion. This study investigates the link between locomotion, femoral structural properties, and femur-pelvis complex morphology. MATERIALS AND METHODS: We measured (1) morphological integration between femoral and pelvic morphologies using geometric morphometrics, and (2) covariation between femoral/pelvic morphologies and femoral diaphyseal cross-sectional properties, which we defined as morpho-structural integration...
March 16, 2024: American journal of biological anthropology
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