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https://www.readbyqxmd.com/read/28102965/isotope-probing-of-the-udp-apiose-udp-xylose-synthase-reaction-evidence-of-a-mechanism-via-a-coupled-oxidation-and-aldol-cleavage
#1
Thomas Eixelsberger, Doroteja Horvat, Alexander Gutmann, Hansjörg Weber, Bernd Nidetzky
The C-branched sugar d-apiose (Api) is essential for plant cell-wall development. An enzyme-catalyzed decarboxylation/pyranoside ring-contraction reaction leads from UDP-α-d-glucuronic acid (UDP-GlcA) to the Api precursor UDP-α-d-apiose (UDP-Api). We examined the mechanism of UDP-Api/UDP-α-d-xylose synthase (UAXS) with site-selectively (2) H-labeled and deoxygenated substrates. The analogue UDP-2-deoxy-GlcA, which prevents C-2/C-3 aldol cleavage as the plausible initiating step of pyranoside-to-furanoside conversion, did not give the corresponding Api product...
January 19, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28102845/h19-let-7-lin28-reciprocal-negative-regulatory-circuit-promotes-breast-cancer-stem-cell-maintenance
#2
Fei Peng, Ting-Ting Li, Kai-Li Wang, Guo-Qing Xiao, Ju-Hong Wang, Hai-Dong Zhao, Zhi-Jie Kang, Wen-Jun Fan, Li-Li Zhu, Mei Li, Bai Cui, Fei-Meng Zheng, Hong-Jiang Wang, Eric W-F Lam, Bo Wang, Jie Xu, Quentin Liu
Long noncoding RNA-H19 (H19), an imprinted oncofetal gene, has a central role in carcinogenesis. Hitherto, the mechanism by which H19 regulates cancer stem cells, remains elusive. Here we show that breast cancer stem cells (BCSCs) express high levels of H19, and ectopic overexpression of H19 significantly promotes breast cancer cell clonogenicity, migration and mammosphere-forming ability. Conversely, silencing of H19 represses these BCSC properties. In concordance, knockdown of H19 markedly inhibits tumor growth and suppresses tumorigenesis in nude mice...
January 19, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28102834/basis-of-catalytic-assembly-of-the-mitotic-checkpoint-complex
#3
Alex C Faesen, Maria Thanasoula, Stefano Maffini, Claudia Breit, Franziska Müller, Suzan van Gerwen, Tanja Bange, Andrea Musacchio
Accurate genome inheritance by daughter cells requires that sister chromatids in the mother attach to microtubules emanating from opposite poles of the mitotic spindle (bi-orientation). A surveillance mechanism named the spindle assembly checkpoint (SAC) monitors the microtubule attachment process, temporarily halting sister chromatid separation and mitotic exit until completion of bi-orientation1. SAC failure results in abnormal chromosome numbers (aneuploidy), a hallmark of many tumours. The HORMA domain protein MAD2 is a subunit of the SAC effector mitotic checkpoint complex (MCC)...
January 19, 2017: Nature
https://www.readbyqxmd.com/read/28102520/us-fda-perspective-on-elbasvir-grazoprevir-treatment-for-patients-with-chronic-hepatitis-c-virus-genotype-1-or-4-infection
#4
Sarita D Boyd, LaRee Tracy, Takashi E Komatsu, Patrick R Harrington, Prabha Viswanathan, Jeff Murray, Adam Sherwat
Elbasvir/grazoprevir demonstrated high sustained virologic response rates 12 weeks after the end of treatment (SVR12) across five clinical trials in subjects infected with chronic hepatitis C virus (HCV) genotype 1, including those with advanced chronic kidney disease (CKD), and GT4. Despite favorable results overall, the US Food and Drug Administration (FDA) encountered challenging regulatory issues due to the limitations of clinical trial data in certain subpopulations. In GT1a-infected subjects, baseline NS5A resistance-associated polymorphisms emerged as the strongest baseline characteristic associated with diminished SVR12 rates following 12 weeks of elbasvir/grazoprevir treatment...
January 19, 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/28102391/enhancement-in-catalytic-proton-reduction-by-an-internal-base-in-a-diiron-pentacarbonyl-complex-its-synthesis-characterisation-inter-conversion-and-electrochemical-investigation
#5
Zhimei Li, Zhiyin Xiao, Fenfen Xu, Xianghua Zeng, Xiaoming Liu
The reaction of a tripodal ligand (H2L) with a {S2N} donor-set with tri-iron dodecacarbonyl in toluene leads to the isolation of a diiron pentacarbonyl complex 1 as a model for the sub-site of the [FeFe]-hydrogenase. Protonation of this complex under CO (1 atm.) forms quantitatively the hexacarbonyl complex 2H+ with a pendant pyridinium group. Infrared spectroscopic investigations indicate that its pendant pyridinium group dissociates to give hexacarbonyl complex 2 which forms subsequently the pentacarbonyl complex 1...
January 19, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28102356/unlocking-the-potential-of-sns2-transition-metal-catalyzed-utilization-of-reversible-conversion-and-alloying-reactions
#6
Zhi Xiang Huang, Ye Wang, Bo Liu, Dezhi Kong, Jun Zhang, Tupei Chen, Hui Ying Yang
The alloying-dealloying reactions of SnS2 proceeds with the initial conversion reaction of SnS2 with lithium that produces Li2S. Unfortunately, due to the electrochemical inactivity of Li2S, the conversion reaction of SnS2 is irreversible, which significantly limit its potential applications in lithium-ion batteries. Herein, a systematic understanding of transition metal molybdenum (Mo) as a catalyst in SnS2 anode is presented. It is found that Mo catalyst is able to efficiently promote the reversible conversion of Sn to SnS2...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28102336/differential-effects-of-phytotherapic-preparations-in-the-hsod1-drosophila-melanogaster-model-of-als
#7
Francescaelena De Rose, Roberto Marotta, Giuseppe Talani, Tiziano Catelani, Paolo Solari, Simone Poddighe, Giuseppe Borghero, Francesco Marrosu, Enrico Sanna, Sanjay Kasture, Elio Acquas, Anna Liscia
The present study was aimed at characterizing the effects of Withania somnifera (Wse) and Mucuna pruriens (Mpe) on a Drosophila melanogaster model for Amyotrophic Lateral Sclerosis (ALS). In particular, the effects of Wse and Mpe were assessed following feeding the flies selectively overexpressing the wild human copper, zinc-superoxide dismutase (hSOD1-gain-of-function) in Drosophila motoneurons. Although ALS-hSOD1 mutants showed no impairment in life span, with respect to GAL4 controls, the results revealed impairment of climbing behaviour, muscle electrophysiological parameters (latency and amplitude of ePSPs) as well as thoracic ganglia mitochondrial functions...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28102320/polarization-conversion-in-plasmonic-nanoantennas-for-metasurfaces-using-structural-asymmetry-and-mode-hybridization
#8
Peter R Wiecha, Leo-Jay Black, Yudong Wang, Vincent Paillard, Christian Girard, Otto L Muskens, Arnaud Arbouet
Polarization control using single plasmonic nanoantennas is of interest for subwavelength optical components in nano-optical circuits and metasurfaces. Here, we investigate the role of two mechanisms for polarization conversion by plasmonic antennas: Structural asymmetry and plasmon hybridization through strong coupling. As a model system we investigate L-shaped antennas consisting of two orthogonal nanorods which lengths and coupling strength can be independently controlled. An analytical model based on field susceptibilities is developed to extract key parameters and to address the influence of antenna morphology and excitation wavelength on polarization conversion efficiency and scattering intensities...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28102229/the-neurosteroidogenic-enzyme-5%C3%AE-reductase-mediates-psychotic-like-complications-of-sleep-deprivation
#9
Roberto Frau, Valentina Bini, Alessio Soggiu, Simona Scheggi, Alessandra Pardu, Silvia Fanni, Paola Roncada, Monica Puligheddu, Francesco Marrosu, Donatella Caruso, Paola Devoto, Marco Bortolato
Acute sleep deprivation (SD) can trigger or exacerbate psychosis- and mania-related symptoms; the neurobiological basis of these complications, however, remains elusive. Given the extensive involvement of neuroactive steroids in psychopathology, we hypothesized that the behavioral complications of SD may be contributed by 5α-reductase (5αR), the rate-limiting enzyme in the conversion of progesterone into the neurosteroid allopregnanolone. We first tested whether rats exposed to SD may exhibit brain-regional alterations in 5αR isoenzymes and neuroactive steroid levels; then, we assessed whether the behavioral and neuroendocrine alterations induced by SD may be differentially modulated by the administration of the 5αR inhibitor finasteride, as well as progesterone and allopregnanolone...
January 19, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28101986/size-dependent-activity-of-palladium-nanoparticles-pd-nps-efficient-conversion-of-co2-into-formate-at-low-overpotentials
#10
Motiar Rahaman, Abhijit Dutta, Peter Broekmann
We report a remarkable size-dependent activity of palladium nanoparticles towards formate production at very low overpotentials (-0.1 V to -0.5 V vs RHE). Size-selective Pd-NPs have been chemically synthesized in the range from 3.8nm to 10.7nm. Electrochemical CO₂ reduction reaction was carried out in aqueous 0.5M NaHCO₃ solution. The Faradaic efficiency of formate production (FE/formate) exceeds more than 86% at E = -0.1 V vs RHE on 3.8nm Pd-NPs whereas on 6.5 nm Pd-NPs an even higher FEformate of 98% is observed...
January 19, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28101949/highly-active-three-dimensional-nife-cu2o-nanowires-cu-foam-electrode-for-water-oxidation
#11
Yan Gao, Hu Chen, Licheng Sun
Water splitting is of paramount importance for exploiting renewable energy conversion and storage systems, but is greatly hindered by the kinetically sluggish oxygen evolution reaction. Here, we develop a three-dimensional, greatly efficient and durable NiFe/Cu2O nanowires/Cu foam anode (NiFe/Cu2O NWs/CF) for water oxidation in 1.0 M KOH. The obtained electrode exhibited a current density of 10 mA/cm2 at a uniquely low overpotential of 215 mV and can keep a steady current density of 100 mA/cm2 for 50 h at an overpotential of 260 mV...
January 18, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28101795/locally-advanced-pancreatic-cancer-successfully-treated-by-distal-pancreatectomy-with-celiac-axis-resection-dp-car-after-s-1-with-radiation-therapy-followed-by-gemcitabine-nab-paclitaxel-therapy-a-case-report
#12
Kyohei Ariake, Fuyuhiko Motoi, Masamichi Mizuma, Keigo Murakami, Tatsuyuki Takadate, Hideo Ohtsuka, Koji Fukase, Kunihiro Masuda, Hiroki Hayashi, Kei Nakagawa, Naoaki Sakata, Takanori Morikawa, Shimpei Maeda, Takeshi Naitoh, Shinichi Egawa, Michiaki Unno
BACKGROUND: The prognosis for pancreatic cancer remains dismal because many patients are diagnosed with unresectable cancer at the initial diagnosis. Recently, conversion surgery was reported as an effective treatment for initially unresectable pancreatic cancer with a favorable response to non-surgical treatment lasting over 240 days. Here, we describe a case of locally advanced pancreatic cancer (LAPC) successfully resected after treatment with S-1 and radiation followed by gemcitabine/nab-paclitaxel therapy...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28101733/3d-absorbed-dose-distribution-estimated-by-monte-carlo-simulation-in-radionuclide-therapy-with-a-monoclonal-antibody-targeting-synovial-sarcoma
#13
David Sarrut, Jean-Noël Badel, Adrien Halty, Gwenaelle Garin, David Perol, Philippe Cassier, Jean-Yves Blay, David Kryza, Anne-Laure Giraudet
BACKROUND: Radiolabeled OTSA101, a monoclonal antibody targeting synovial sarcoma (SS) developed by OncoTherapy Science, was used to treat relapsing SS metastases following a theranostic procedure: in case of significant (111)In-OTSA101 tumor uptake and favorable biodistribution, patient was randomly treated with 370/1110 MBq (90)Y-OTSA101. Monte Carlo-based 3D dosimetry integrating time-activity curves in VOI was performed on (111)In-OTSA101 repeated SPECT/CT. Estimated absorbed doses (AD) in normal tissues were compared to biological side effects and to the admitted maximal tolerated absorbed dose (MTD) in normal organs...
December 2017: EJNMMI Physics
https://www.readbyqxmd.com/read/28101711/catalytic-performance-of-graphene-bimetallic-composite-for-heterogeneous-oxidation-of-acid-orange-7-from-aqueous-solution
#14
Jiebing Li, Asif Hussain, Dengxin Li, Ming Yang, Shihong Xu
In this study, reduced graphene oxide (rGO) embedded with bimetallic nanoparticles of cobalt-manganese oxide (CoMn2O4) was fabricated by hydrothermal treatment. The obtained product was characterized and applied for the heterogeneous activation of peroxymonosulfate (PMS) to degrade acid orange 7 (AO7). The characterization results revealed that 10-20 nm nanosized CoMn2O4 was homogenously decorated on the surface of rGO. The effect of different CoMn2O4 loadings showed that catalyst with a CoMn2O4 contents higher than 20% performs stronger capability for catalytic degradation of AO7 compared to pure CoMn2O4...
January 18, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28101665/feasibility-and-psychometric-properties-of-the-adjusted-dswal-qol-questionnaire-for-dysphagic-patients-with-additional-language-and-or-cognitive-impairment-part-i
#15
Ingeborg S Simpelaere, Jan Vanderwegen, Kristien Wouters, Marc De Bodt, Gwen Van Nuffelen
The Swallowing Quality-of-Life questionnaire (SWAL-QoL) is considered the gold standard for assessing health-related quality of life in people with dysphagia. However, many dysphagic patients struggle to complete this questionnaire because of additional functional sequelae such as language impairment and cognitive disorders. In this study, we sought to develop an adjusted Dutch version of the SWAL-QoL (aDSWALQoL) and to evaluate its psychometric properties and feasibility compared with the original questionnaire...
January 18, 2017: Dysphagia
https://www.readbyqxmd.com/read/28101639/laparoscopic-hysteropexy-10%C3%A2-years-experience
#16
Helen Jefferis, Natalia Price, Simon Jackson
INTRODUCTION AND HYPOTHESIS: Uterine prolapse is common and has traditionally been treated by vaginal hysterectomy. Increasingly, women are seeking uterine-preserving alternatives. Laparoscopic hysteropexy offers resuspension of the uterus using polypropylene mesh. We report on 10 years' experience with this technique. METHODS: All hysteropexy procedures in our unit since 2006 were reviewed. Primary outcome was safety of hysteropexy, as assessed by intraoperative and major postoperative complications...
January 18, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28101579/role-of-trna-selenocysteine-1-associated-protein-1-in-the-proliferation-and-apoptosis-of-cardiomyocyte%C3%A2-like-h9c2-cells
#17
Meng-Di Li, Wan-Peng Cheng, Min-Xia Shi, Tang-Dong Ge, Xiao-Lin Zheng, Dong-Yuan Wu, Xiao-Yan Hu, Jin-Cheng Luo, Feng-Lan Li, Hui Li
Transfer RNA selenocysteine 1 associated protein 1 (Trnau1ap) serves an essential role in the synthesis of selenoproteins, which have critical functions in numerous biological processes. Selenium deficiency results in a variety of diseases, including cardiac disease. However, the mechanisms underlying myocardial injury induced by selenium deficiency remain unclear. The present study examined the effects of Trnau1ap under‑ and overexpression in cardiomyocyte‑like H9c2 cells, by transfection with small interfering RNA and an overexpression plasmid, respectively...
February 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28101451/laparoscopic-vs-open-donor-nephrectomy-lessons-learnt-from-single-academic-center-experience
#18
Georgios Tsoulfas, Polyxeni Agorastou, Dicken S C Ko, Martin Hertl, Nahel Elias, A B Cosimi, Tatsuo Kawai
AIM: To compare laparoscopic and open living donor nephrectomy, based on the results from a single center during a decade. METHODS: This is a retrospective review of all living donor nephrectomies performed at the Massachusetts General Hospital, Harvard Medical School, Boston, between 1/1998 - 12/2009. Overall there were 490 living donors, with 279 undergoing laparoscopic living donor nephrectomy (LLDN) and 211 undergoing open donor nephrectomy (OLDN). Demographic data, operating room time, the effect of the learning curve, the number of conversions from laparoscopic to open surgery, donor preoperative glomerular filtration rate and creatinine (Cr), donor and recipient postoperative Cr, delayed graft function and donor complications were analyzed...
January 6, 2017: World Journal of Nephrology
https://www.readbyqxmd.com/read/28101447/functional-coupling-of-v-atpase-and-clc-5
#19
REVIEW
Nobuhiko Satoh, Masashi Suzuki, Motonobu Nakamura, Atsushi Suzuki, Shoko Horita, George Seki, Kyoji Moriya
Dent's disease is an X-linked renal tubulopathy characterized by low molecular weight proteinuria, hypercalciuria and progressive renal failure. Disease aetiology is associated with mutations in the CLCN5 gene coding for the electrogenic 2Cl(-)/H(+) antiporter chloride channel 5 (CLC-5), which is expressed in the apical endosomes of renal proximal tubules with the vacuolar type H(+)-ATPase (V-ATPase). Initially identified as a member of the CLC family of Cl(-) channels, CLC-5 was presumed to provide Cl(-) shunt into the endosomal lumen to dissipate H(+) accumulation by V-ATPase, thereby facilitating efficient endosomal acidification...
January 6, 2017: World Journal of Nephrology
https://www.readbyqxmd.com/read/28101328/perceived-health-status-in-a-comparative-perspective-methodological-limitations-and-policy-implications-for-israel
#20
Baruch Levi
BACKGROUND: The perceived health status indicator included in the OECD Health Statistics suffers from severe methodological limitations related to data collection. Furthermore, this indicator is also included in the OECD's Better Life Index, thus distorting the total health score of some OECD countries, among them Israel. The purpose of this paper is to explore the erroneous use of OECD health data in Israel and to warn of its implications. METHODS: Analysis of data from the OECD Health Database, Better Life Index and the Israeli Central Bureau of Statistics, review of media reports and governmental documents concerning health measures, conversations and correspondence held with officials in the relevant organizations...
2017: Israel Journal of Health Policy Research
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