keyword
MENU ▼
Read by QxMD icon Read
search

human pregnancy

keyword
https://www.readbyqxmd.com/read/29168438/impact-of-sex-composition-of-living-children-and-couples-agreement-on-subsequent-fertility-in-india
#1
Anshul Kastor, Sayantani Chatterjee
The desire for children could be considered a reliable predictor of subsequent fertility. At the same time, the sex composition of surviving children, along with other demographic and socioeconomic factors, may affect a couple's fertility desire and, therefore, their subsequent fertility. This study examined the impact of the sex composition of living children and a couple's agreement on fertility desire on their subsequent fertility in India using data came from two rounds of nationally representative surveys: the India Human Development Survey (IHDS)-I (2004-05) and IHDS-II (2011-12)...
November 23, 2017: Journal of Biosocial Science
https://www.readbyqxmd.com/read/29165645/down-regulation-of-mir-378a-3p-induces-decidual-cell-apoptosis-a-possible-mechanism-for-early-pregnancy-loss
#2
Lihua Hong, Tiantian Yu, Haiyan Xu, Ningning Hou, Qi Cheng, Lihua Lai, Qingqing Wang, Jianzhong Sheng, Hefeng Huang
STUDY QUESTION: Do microRNAs (miRNAs) contribute to human early pregnancy loss (EPL)? SUMMARY ANSWER: miR-378a-3p expression is regulated by progesterone and is down-regulated in ducidua of EPL patients which may contribute to decidual apoptosis through Caspase-3 activation. WHAT IS KNOWN ALREADY: A variety of miRNAs have been demonstrated to be associated with the development of decidualization and placental formation. However, little has been reported on the roles of miRNA in the pathogenesis of EPL...
November 18, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29164748/maternal-protein-malnutrition-induced-hypertension-new-evidence-about-the-autonomic-and-respiratory-dysfunctions-and-epigenetic-mechanisms
#3
REVIEW
José Luiz de Brito Alves, João Henrique Costa-Silva
Maternal protein malnutrition during the critical stages of development (pregnancy, lactation and first infancy) can lead to adult hypertension. Studies have shown that renal and cardiovascular dysfunctions can be associated to the development of hypertension in humans and rats exposed to maternal protein malnutrition. The etiology of hypertension, however, includes a complex network involved in central and peripheral blood pressure control. Recently, the hyperactivity of the sympathetic nervous system in protein restricted rats has been reported...
November 22, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29164084/pretreatment-with-human-chorionic-gonadotropin-protects-the-neonatal-brain-against-the-effects-of-hypoxic-ischemic-injury
#4
Tammy Z Movsas, Rebecca L Weiner, M Banks Greenberg, David M Holtzman, Rafael Galindo
Introduction: Though the human fetus is exposed to placentally derived human chorionic gonadotropin (hCG) throughout gestation, the role of hCG on the fetal brain is unknown. Review of the available literature appears to indicate that groups of women with higher mean levels of hCG during pregnancy tend to have offspring with lower cerebral palsy (CP) risk. Given that newborn cerebral injury often precedes the development of CP, we aimed to determine whether hCG may protect against the neurodegenerative effects of neonatal brain injury...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29163791/abnormal-cyp11a1-gene-expression-induces-excessive-autophagy-contributing-to-the-pathogenesis-of-preeclampsia
#5
Tianying Pan, Guolin He, Meng Chen, Chenyi Bao, Yan Chen, Guangyu Liu, Mi Zhou, Shuying Li, Wenming Xu, Xinghui Liu
Objective: In this study, we investigated the exact mechanism by which excessive CYP11A1 expression impairs the placentation process and whether this causes preeclampsia (PE) in an in vivo model. Setting and Design: In order to study CYP11A1 overexpression, BeWo cells were transfected with CYP11A1. Pregnenolone, progesterone, and testosterone levels were measured by enzyme linked immunosorbent assays, and levels of autophagy markers were quantified by western blotting and immunofluorescence...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29163762/bmal1-facilitates-trophoblast-migration-and-invasion-via-sp1-dnmt1-dab2ip-pathway-in-recurrent-spontaneous-abortion
#6
Shang Li, Junyu Zhai, Jiansheng Liu, Yan Hong, Weixiu Zhao, Aimin Zhao, Kang Sun, Yanzhi Du, Zi-Jiang Chen
The underlying mechanism about rhythms and epigenetics leading to aberrant trophoblast migration and invasion in recurrent spontaneous abortion (RSA) remains unknown. Brain and muscle ARNT-like protein 1 (BMAL1) is considered as a crucial role in fertility, and polymorphism of BMAL1 gene has been reported to be associated with risk of miscarriage. However, the functional role of BMAL1 in RSA is not fully understood. Previous study shows the descended expression of DNA 5'-cytosine-methyltransferases 1 (DNMT1) in the villous of early pregnancy loss...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29163373/placental-nutrient-transport-in-gestational-diabetic-pregnancies
#7
REVIEW
Marisol Castillo-Castrejon, Theresa L Powell
Maternal obesity during pregnancy is rising and is associated with increased risk of developing gestational diabetes mellitus (GDM), defined as glucose intolerance first diagnosed in pregnancy (1). Fetal growth is determined by the maternal nutrient supply and placental nutrient transfer capacity. GDM-complicated pregnancies are more likely to be complicated by fetal overgrowth or excess adipose deposition in utero. Infants born from GDM mothers have an increased risk of developing cardiovascular and metabolic disorders later in life...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29163363/human-prolactin-point-mutations-and-their-projected-effect-on-vasoinhibin-generation-and-vasoinhibin-related-diseases
#8
Jakob Triebel, Christin J Friedrich, Andreas Leuchs, Gonzalo Martínez de la Escalera, Carmen Clapp, Thomas Bertsch
Background: A dysregulation of the generation of vasoinhibin hormones by proteolytic cleavage of prolactin (PRL) has been brought into context with diabetic retinopathy, retinopathy of prematurity, preeclampsia, pregnancy-induced hypertension, and peripartum cardiomyopathy. Factors governing vasoinhibin generation are incompletely characterized, and the composition of vasoinhibin isoforms in human tissues or compartments, such as the circulation, is unknown. The aim of this study was to determine the possible contribution of PRL point mutations to the generation of vasoinhibins as well as to project their role in vasoinhibin-related diseases...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29161966/altered-downstream-target-gene-expression-of-the-placental-vitamin-d-receptor-in-human-idiopathic-fetal-growth-restriction
#9
Thy Ph Nguyen, Hannah Ej Yong, Tejasvy Chollangi, Shaun P Brennecke, Susan J Fisher, Euan M Wallace, Peter R Ebeling, Padma Murthi
Fetal growth restriction (FGR) affects up to 5% of pregnancies and is associated with significant perinatal complications. Maternal deficiency of vitamin D, a secosteroid hormone, is common in FGR-affected pregnancies. We recently demonstrated that decreased expression of the vitamin D receptor (VDR) in idiopathic FGR placentae could impair trophoblast growth. As strict regulation of cell-cycle genes in trophoblast cells is critical for optimal feto-placental growth, we hypothesised that pathologically decreased placental VDR contributes to aberrant regulation of cell-cycle genes...
November 22, 2017: Cell Cycle
https://www.readbyqxmd.com/read/29161658/reproductive-performance-of-lactating-dairy-cows-after-inducing-ovulation-using-hcg-in-a-five-day-progesterone-based-fixed-time-ai-protocol
#10
I Garcia-Ispierto, F De Rensis, X Casas, F Caballero, R Mur-Novales, F López-Gatius
This study compares the effects of inducing ovulation using human chorionic gonadotropin (hCG) or gonadotropin releasing hormone (GnRH) at the end of a 5-day progesterone(P4)-based protocol for fixed-time artificial insemination (FTAI) in lactating dairy cows on ovarian dynamics and fertility. A P4 intravaginal device (PRID) was fitted for five days and GnRH administered upon PRID insertion and a double dose (24 h apart) of prostaglandin F2α upon PRID removal. Cows received either GnRH (GnRH group; n = 98), 1000 IU hCG (hCG-1 group; n = 97), or 3000 IU hCG (hCG-2 group; n = 104) 36 h after PRID removal and were inseminated 50-56 h after PRID removal...
November 15, 2017: Theriogenology
https://www.readbyqxmd.com/read/29161633/urinary-concentrations-of-biomarkers-of-phthalates-and-phthalate-alternatives-and-ivf-outcomes
#11
Ronit Machtinger, Audrey J Gaskins, Catherine Racowsky, Abdallah Mansur, Michal Adir, Andrea A Baccarelli, Antonia M Calafat, Russ Hauser
Phthalates are a class of chemicals found in a large variety of consumer products. Available experimental and limited human data show adverse effects of some phthalates on ovarian function, which has raised concerns regarding potential effects on fertility. The aim of the current study was to determine whether urinary concentrations of metabolites of phthalates and phthalate alternatives are associated with intermediate and clinical in vitro fertilization (IVF) outcomes. We enrolled 136 women undergoing IVF in a Tertiary University Affiliated Hospital...
November 18, 2017: Environment International
https://www.readbyqxmd.com/read/29161409/transfer-and-metabolism-of-cortisol-by-the-isolated-perfused-human-placenta
#12
Laura I Stirrat, Bram G Sengers, Jane E Norman, Natalie Z M Homer, Ruth Andrew, Rohan M Lewis, Rebecca M Reynolds
Context: Fetal overexposure to glucocorticoids in utero is associated with fetal growth restriction and is postulated to be a key mechanism linking suboptimal fetal growth with cardiovascular disease in later life. Objective: To develop a model to predict maternal-fetal glucocorticoid transfer. We hypothesised placental 11β-HSD2 would be the major rate-limiting step in maternal cortisol transfer to the fetus. Design: We used a deuterated cortisol tracer in the ex vivo placental perfusion model, in combination with computational modelling, to investigate the role of interconversion of cortisol and its inactive metabolite cortisone on transfer of cortisol from mother to fetus...
November 16, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29160594/leptin-action-in-normal-and-pathological-pregnancies
#13
REVIEW
Antonio Pérez-Pérez, Ayelén Toro, Teresa Vilariño-García, Julieta Maymó, Pilar Guadix, José L Dueñas, Manuel Fernández-Sánchez, Cecilia Varone, Víctor Sánchez-Margalet
Leptin is now considered an important signalling molecule of the reproductive system, as it regulates the production of gonadotrophins, the blastocyst formation and implantation, the normal placentation, as well as the foeto-placental communication. Leptin is a peptide hormone secreted mainly by adipose tissue, and the placenta is the second leptin-producing tissue in humans. Placental leptin is an important cytokine which regulates placental functions in an autocrine or paracrine manner. Leptin seems to play a crucial role during the first stages of pregnancy as it modulates critical processes such as proliferation, protein synthesis, invasion and apoptosis in placental cells...
November 21, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29160431/classification-of-deaths-in-women-with-human-immunodeficiency-virus-acquired-immunodeficiency-syndrome-in-pregnancy-and-childbirth
#14
Manuella Coutinho Brayner, Sandra Valongueiro Alves
OBJECTIVE: To reclassify deaths of women infected with the human immunodeficiency virus/acquired immunodeficiency syndrome in pregnancy and childbirth in the State of Pernambuco, Brazil, from 2000 to 2010. METHODS: A descriptive exploratory study, developed from the following steps: translation to Portuguese of the item "HIV and aids" of the United Nations document "The WHO application of ICD-10 to deaths during pregnancy, childbirth and the puerperium: DCI MM 2012"; development of a classification algorithm of deaths of women living with the human immunodeficiency virus/acquired immunodeficiency syndrome in pregnancy and childbirth; and reclassification of deaths by a group of experts...
July 2017: Revista Brasileira de Epidemiologia, Brazilian Journal of Epidemiology
https://www.readbyqxmd.com/read/29158352/intracytoplasmic-sperm-injection-state-of-the-art-in-humans
#15
Gianpiero D Palermo, Claire L O'Neill, Stephen Chow, Stephanie Cheung, Alessandra Parrella, Nigel Pereira, Zev Rosenwaks
Amongst infertile couples, 25% involve both male and female factors, while male factor alone accounts for another 25% due to oligo-, astheno-, terato-zoospermia, a combination of the three, or even a complete absence of sperm cells in the ejaculate and can lead to a poor prognosis even with the help of assisted reproductive technology (ART). Intracytoplasmic sperm injection (ICSI) has been with us now for a quarter of a century and in spite of the controversy generated since its inception, it remains in the forefront of the techniques utilized in ART...
November 20, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29157995/in-the-ovine-pituitary-cxcr4-is-localized-in-gonadotropes-and-somatotropes-and-increases-with-elevated-serum-progesterone
#16
N S Sanchez, K E Quinn, A K Ashley, R L Ashley
The pituitary is the central endocrine regulator of reproduction and in addition to various hormones regulating its actions, other molecules, such as chemokines, influence pituitary physiology as well. Despite reports over 2 decades ago that chemokines regulate the pituitary, much of the basic biology discerning chemokine action in the pituitary is unclear. A small number of chemokines and their receptors have been localized to the pituitary, yet chemokine ligand 12 (CXCL12) and its receptor, CXCR4, have received the most attention as both are increased in human pituitary adenomas...
October 28, 2017: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/29157955/development-of-a-goat-model-for-evaluation-of-withaferin-a-cervical-implants-for-the-treatment-of-cervical-intraepithelial-neoplasia
#17
Leslie C Sherwood, Farrukh Aqil, Manicka V Vadhanam, Jeyaprakash Jeyabalan, Radha Munagala, David Hoetker, Sanjay Srivastava, Inder P Singh, Scott Cambron, Martin O'Toole, Wendy Spencer, Lynn P Parker, Ramesh C Gupta
Cervical cancer is caused by human papillomavirus (HPV). The disease develops over many years through a series of precancerous lesions. Cervical cancer can be prevented by HPV-vaccination, screening and treatment of precancer before development of cervical cancer. The treatment of high-grade cervical dysplasia (CIN(2+)) has traditionally been by cervical conization. Surgical procedures are associated with increased risk of undesirable side effects including bleeding, infection, scarring (stenosis), infertility and complications in later pregnancies...
November 17, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/29157596/molecular-epidemiology-and-phylogenetic-analysis-of-human-papillomavirus-infection-in-women-with-cervical-lesions-and-cancer-from-the-coastal-region-of-ecuador
#18
Cesar H Bedoya-Pilozo, Lex G Medina Magües, Maylen Espinosa-García, Martha Sánchez, Johanna V Parrales Valdiviezo, Denisse Molina, María A Ibarra, María Quimis-Ponce, Karool España, Karla E Párraga Macias, Nancy V Cajas Flores, Solon A Orlando, Jorge A Robalino Penaherrera, Peter Chedraui, Saul Escobar, Rita D Loja Chango, Cecibel Ramirez-Morán, Jasson Espinoza-Caicedo, Sunny Sánchez-Giler, Celia M Limia, Yoan Alemán, Yudira Soto, Vivian Kouri, Andrés C A Culasso, Inés Badano
The aim of the present study was to gather information regarding the molecular epidemiology of Human papillomavirus (HPV) and related risk factors in a group of women with low- and high-grade cervical lesions and cancer from the coastal region of Ecuador. In addition, we studied the evolution of HPV variants from the most prevalent types and provided a temporal framework for their emergence, which may help to trace the source of dissemination within the region. We analyzed 166 samples, including 57 CIN1, 95 CIN2/3 and 14 cancer cases...
November 17, 2017: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/29156647/effects-of-nutritional-interventions-during-pregnancy-on-infant-and-child-cognitive-outcomes-a-systematic-review-and-meta-analysis
#19
REVIEW
Rachael M Taylor, Shanna M Fealy, Alessandra Bisquera, Roger Smith, Clare E Collins, Tiffany-Jane Evans, Alexis J Hure
BACKGROUND: Epidemiological studies have demonstrated that folate, iodine and iron intake during pregnancy impacts on foetal brain development and cognitive function. However, in human studies, the relationship with other dietary nutrients is less clear. OBJECTIVE: This systematic review aims to critically appraise the current literature and meta-analyses results from nutritional interventions during pregnancy that aimed to optimise infant and child cognitive outcomes...
November 20, 2017: Nutrients
https://www.readbyqxmd.com/read/29155939/group-b-streptococcus-activates-transcriptomic-pathways-related-to-premature-birth-in-human-extraplacental-membranes-in-vitro
#20
Hae-Ryung Park, Sean M Harris, Erica Boldenow, Richard C McEachin, Maureen Sartor, Mark Chames, Rita Loch-Caruso
Streptococcus agalactiae (group B streptococcus, GBS) infection in pregnant women is the leading cause of infectious neonatal morbidity and mortality in the United States. Although inflammation during infection has been associated with preterm birth, the contribution of GBS to preterm birth is less certain. Moreover, the early mechanisms by which GBS interacts with the gestational tissue to affect adverse pregnancy outcomes are poorly understood. We hypothesized that short term GBS inoculation activates pathways related to inflammation and premature birth in human extraplacental membranes...
November 16, 2017: Biology of Reproduction
keyword
keyword
108505
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"