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placental oxidative stress

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https://www.readbyqxmd.com/read/29129240/maternal-methyl-donor-supplementation-during-gestation-counteracts-bisphenol-a-induced-oxidative-stress-in-sows-and-offspring
#1
Daolin Mou, Jun Wang, Hong Liu, Yuling Chen, Lianqiang Che, Zhengfeng Fang, Shengyu Xu, Yan Lin, Bin Feng, Jian Li, De Wu
OBJECTIVE: Maternal oxidative stress is harmful for embryonic, fetal, and placental development. The aim of this study was to investigate whether methyl donor supplementation during gestation effectively ameliorates maternal and placenta oxidative stress up to offspring. METHODS: Fifty-six Landrace × Yorkshire sows were randomly allocated to receive one of the following four diets during gestation: control diet (CON); control diet supplemented with methyl donor (MET); control diet supplemented with bisphenol A (BPA); and control diet supplemented with BPA and MET (BPA + MET)...
January 2018: Nutrition
https://www.readbyqxmd.com/read/29127866/placental-hypoxia-inducible-factor-1%C3%AE-chop-immuno-histochemical-expression-relative-to-maternal-circulatory-syncytiotrophoblast-micro-vesicles-in-preeclamptic-and-normotensive-pregnancies
#2
S Verma, P Pillay, T Naicker, J Moodley, I Mackraj
OBJECTIVES: Preeclampsia (PE) occurs as a result placental hypoxia-induced oxidative and endoplasmic reticulum stress, and is associated with the activation of hypoxia inducible factor-1α (HIF-1α) and apoptotic CHOP pathways with the consequential shedding of syncytiotrophoblast microvesicles which may be central in mediating the maternal systemic immune response. The aim of this study was to immune-localise and morphometrically analyse CHOP and HIF-1α within the placenta of normotensive and pre-eclamptic pregnancies and concomitantly quantify syncytiotrophoblast released microvesicles in maternal circulation...
November 7, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29117333/oleic-acid-stimulation-of-motility-of-human-extravillous-trophoblast-cells-is-mediated-by-stearoyl-coa-desaturase-1-activity
#3
Changwon Yang, Whasun Lim, Fuller W Bazer, Gwonhwa Song
STUDY QUESTION: Do fatty acids regulate development and motility of human extravillous trophoblast cells (EVTs)? SUMMARY ANSWER: Oleic acid is a promising lipid molecule that has beneficial effects on motility and development of human EVTs. WHAT IS KNOWN ALREADY: Fatty acid uptake into trophoblast cells is important for maintaining cellular events during pregnancy, but the molecular mechanisms of action of various fatty acids, including trans fatty acids, saturated fatty acids and monounsaturated fatty acids, in EVT cell lines are not clear...
November 1, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/29109771/selective-targeting-of-a-novel-vasodilator-to-the-uterine-vasculature-to-treat-impaired-uteroplacental-perfusion-in-pregnancy
#4
Natalie Cureton, Iana Korotkova, Bernadette Baker, Susan Greenwood, Mark Wareing, Venkata R Kotamraju, Tambet Teesalu, Francesco Cellesi, Nicola Tirelli, Erkki Ruoslahti, John D Aplin, Lynda K Harris
Fetal growth restriction (FGR) in pregnancy is commonly caused by impaired uteroplacental blood flow. Vasodilators enhance uteroplacental perfusion and fetal growth in humans and animal models; however, detrimental maternal and fetal side effects have been reported. We hypothesised that targeted uteroplacental delivery of a vasodilator would enhance drug efficacy and reduce the risks associated with drug administration in pregnancy. Phage screening identified novel peptides that selectively accumulated in the uteroplacental vasculature of pregnant mice...
2017: Theranostics
https://www.readbyqxmd.com/read/29109760/influence-of-serum-hmw-adiponectin-level-in-patients-with-pregnancy-induced-hypertension-syndrome-on-the-occurrence-of-eclampsia-in-secondary-pregnancy
#5
Qian Xu, Dongmei Fan, Fahong Li, Zhanhong Zhang
In the present study, we studied the influence of serum high-molecular weight adiponectin (HMWA) levels in patients with pregnancy-induced hypertension (PIH) on the occurrence of eclampsia in secondary pregnancy and its related mechanisms. In total, 130 patients who were diagnosed with PIH for the first time were selected for this study; the median interval of the secondary pregnancy was 28.5 months. The serum HMWA and leptin levels both times were detected, and the insulin resistance indexes (HOMA-IR) were calculated...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29103803/cd39-and-cd73-activity-are-protective-in-a-mouse-model-of-antiphospholipid-antibody-induced-miscarriages
#6
Anushka N Samudra, Karen M Dwyer, Carly Selan, Susanna Freddi, Lisa Murray-Segal, Mandana Nikpour, Michael J Hickey, Karlheinz Peter, Simon C Robson, Maithili Sashindranath, Peter J Cowan, Harshal H Nandurkar
OBJECTIVE: Antiphospholipid syndrome (APS) is a systemic autoimmune disorder of young adults associated with devastating pregnancy complications (recurrent miscarriages, preeclampsia and low birth weight) and vascular complications including thrombosis. The key components implicated in pathogenesis of APS are the complement cascade and tissue factor (TF) activity causing inflammation and coagulation. Purinergic signalling involving catabolism of ATP to adenosine by cell-surface enzymes CD39 and CD73 has anti-inflammatory and anti-thrombotic effects...
November 2, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/29093562/glucocorticoid-exposure-induces-preeclampsia-via-dampening-1-25-dihydroxyvitamin-d3
#7
Dongxin Zhang, Ji Zeng, Xili Miao, Haojing Liu, Liangfang Ge, Wei Huang, Jinyu Jiao, Duyun Ye
The pathogenesis of preeclampsia (PE) involves a number of biological processes that may be directly or indirectly affected by glucocorticoid (GC) and vitamin D. GC exposure increases the risk of PE, and 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) deficiency may result in PE. The purpose of the present study was to confirm the involvement of GC/1,25-(OH)2D3 axis in the pathogenesis of PE. In the study, cortisol levels of PE patients were found to be higher than that of non-complicated pregnancies, while 1,25-(OH)2D3 were decreased in both PE women and GC-induced PE rats...
November 2, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29069462/sexually-dimorphic-impact-of-chromium-accumulation-on-human-placental-oxidative-stress-and-apoptosis
#8
Sakhila K Banu, Jone A Stanley, Robert J Taylor, Kirthiram K Sivakumar, Joe A Arosh, Lixia Zeng, Subramaniam Pennathur, Vasantha Padmanabhan
Environmental contamination with CrVI is a growing problem both in the U.S and developing countries. CrVI is widely used in numerous industries. Environmental exposure to hexavalent chromium (CrVI) adversely affects pregnancy outcomes and subsequent health of two generations, resulting in higher pregnancy loss, spontaneous abortion and low birth rate. Pregnant women exposed to CrVI through occupational settings experience increased risk of spontaneous abortion, stillbirth, preterm birth, and neonatal death...
October 23, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29049509/prenatal-air-pollution-and-newborns-predisposition-to-accelerated-biological-aging
#9
Dries S Martens, Bianca Cox, Bram G Janssen, Diana B P Clemente, Antonio Gasparrini, Charlotte Vanpoucke, Wouter Lefebvre, Harry A Roels, Michelle Plusquin, Tim S Nawrot
Importance: Telomere length is a marker of biological aging that may provide a cellular memory of exposures to oxidative stress and inflammation. Telomere length at birth has been related to life expectancy. An association between prenatal air pollution exposure and telomere length at birth could provide new insights in the environmental influence on molecular longevity. Objective: To assess the association of prenatal exposure to particulate matter (PM) with newborn telomere length as reflected by cord blood and placental telomere length...
October 16, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/29022011/placental-extract-ameliorates-non-alcoholic-steatohepatitis-nash-by-exerting-protective-effects-on-endothelial-cells
#10
Akihiro Yamauchi, Akiko Kamiyoshi, Teruhide Koyama, Nobuyoshi Iinuma, Shumpei Yamaguchi, Hiroyuki Miyazaki, Eiichi Hirano, Taiichi Kaku, Takayuki Shindo
Non-alcoholic steatohepatitis (NASH) is a severe form of fatty liver disease that is defined by the presence of inflammation and fibrosis, ultimately leading to cirrhosis and hepatocellular carcinoma. Treatment with human placental extract (HPE) reportedly ameliorates the hepatic injury. We evaluated the effect of HPE treatment in a mouse model of NASH. In the methione- and choline-deficient (MCD) diet-induced liver injury model, fibrosis started from regions adjacent to the sinusoids. We administered the MCD diet with high-salt loading (8% NaCl in the drinking water) to mice deficient in the vasoprotective molecule RAMP2 for 5 weeks, with or without HPE...
September 2017: Heliyon
https://www.readbyqxmd.com/read/29017408/matrix-metalloproteinase-2-c-735t-and-its-interaction-with-matrix-metalloproteinase-7-a-181g-polymorphism-are-associated-with-the-risk-of-preeclampsia-influence-on-total-antioxidant-capacity-and-blood-pressure
#11
Ziba Rahimi, Sarah Lotfi, Abbas Ahmadi, Nasrin Jalilian, Ebrahim Shakiba, Asad Vaisi-Raygani, Zohreh Rahimi
Matrix metalloproteinase (MMP) -2 C-735 T and MMP-7 A-181 G genotypes were studied in 144 pregnant patients with mild and severe preeclampsia and 103 healthy pregnant women. Significantly higher frequencies of CT and TT genotypes in patients compared to controls increased the risk of preeclampsia by 2.42 and 3.13 times, respectively. In severe preeclamptic women in the presence of MMP-2 CT the level of total antioxidant capacity was significantly lower than MMP-2 CC genotype. Also, in the presence of MMP-2 CT + TT blood pressure was significantly increased compared to CC genotype in all the patients...
October 10, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28992178/tadalafil-improves-l-ng-nitroarginine-methyl-ester-induced-preeclampsia-with-fetal-growth-restriction-like-symptoms-in-pregnant-mice
#12
Kento Yoshikawa, Takashi Umekawa, Shintaro Maki, Michiko Kubo, Masafumi Nii, Kayo Tanaka, Hiroaki Tanaka, Kazuhiro Osato, Yuki Kamimoto, Eiji Kondo, Kenji Ikemura, Masahiro Okuda, Kan Katayama, Takekazu Miyoshi, Hiroshi Hosoda, Ning Ma, Toshimichi Yoshida, Tomoaki Ikeda
BACKGROUND: We investigated the efficacy and mechanisms of tadalafil, a selective phosphodiesterase 5 inhibitor, in treating preeclampsia (PE) with fetal growth restriction (FGR) using L-NG-nitroarginine methyl ester (L-NAME)-induced PE with FGR in pregnant mice as our experimental model. METHODS: C57BL/6 mice were divided into 2 groups 11 days postcoitum (d.p.c.). A control group of dams (C dam) received 0.5% carboxymethylcellulose (CMC). A L-NAME-treated group received 1 mg/ml L-NAME dissolved in CMC...
August 3, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28974763/maternal-gestational-diabetes-mellitus-increases-placental-and-foetal-lipoprotein-associated-phospholipase-a2-which-might-exert-protective-functions-against-oxidative-stress
#13
Carolin Schliefsteiner, Birgit Hirschmugl, Susanne Kopp, Sanja Curcic, Eva Maria Bernhart, Gunther Marsche, Uwe Lang, Gernot Desoye, Christian Wadsack
Increased Lipoprotein associated phospholipase A2 (LpPLA2) has been associated with inflammatory pathologies, including Type 2 Diabetes. Studies on LpPLA2 and Gestational Diabetes Mellitus (GDM) are rare, and have focused mostly on maternal outcome. In the present study, we investigated whether LpPLA2 activity on foetal lipoproteins is altered by maternal GDM and/or obesity (a major risk factor for GDM), thereby contributing to changes in lipoprotein functionality. We identified HDL as the major carrier of LpPLA2 activity in the foetus, which is in contrast to adults...
October 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28942512/altered-endothelial-nitric-oxide-signaling-as-a-paradigm-for-maternal-vascular-maladaptation-in-preeclampsia
#14
REVIEW
George Osol, Nga Ling Ko, Maurizio Mandalà
PURPOSE OF REVIEW: The goal of this review is to present the newest insights into what we view as a central failure of cardiovascular adaptation in preeclampsia (PE) by focusing on one clinically significant manifestation of maternal endothelial dysfunction: nitric oxide signaling. The etiology, symptoms, and current theories of the PE syndrome are described first, followed by a review of the available evidence, and underlying causes of reduced endothelial nitric oxide (NO) signaling in PE...
September 23, 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28916946/association-between-placental-polycyclic-aromatic-hydrocarbons-pahs-oxidative-stress-and-preterm-delivery-a-case-control-study
#15
Priyanka Agarwal, Laxmi Singh, Madhu Anand, Ajay Taneja
Polycyclic aromatic hydrocarbons are known to disturb the antioxidant defense system, which may indirectly contribute to induction of early pregnancy in women. Therefore, the present investigation was designed to offer preliminary information about exposure to PAHs by estimating their placental levels and its association with oxidative stress as well as with preterm birth. Placenta tissue samples were drawn after delivery from 84 healthy pregnant women, recruited at a local nursing home of Agra, India, and levels of PAHs were quantified by gas chromatograph equipped with flame ionization detector...
September 15, 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28890952/oxidative-stress-a-potential-therapeutic-target-in-placental-malaria
#16
Demba Sarr, Caitlin A Cooper, Tara C Bracken, Omar Martinez-Uribe, Tamas Nagy, Julie M Moore
Placental malaria, characterized by sequestration of Plasmodium falciparum in the maternal placental blood space and associated inflammatory damage, contributes to poor birth outcomes and ~200,000 infant deaths annually. Specific mechanisms that contribute to placental damage and dysfunction during malaria are not completely understood. To investigate a potential role for oxidative stress, antioxidant genes and markers for oxidative damage were assessed by quantitative PCR and immunohistochemistry in Plasmodium chabaudi AS-infected pregnant mice...
June 1, 2017: Immunohorizons
https://www.readbyqxmd.com/read/28883908/increased-levels-of-oxidative-stress-markers-soluble-cd40-ligand-and-carotid-intima-media-thickness-reflect-acceleration-of-atherosclerosis-in-male-patients-with-ankylosing-spondylitis-in-active-phase-and-without-the-classical-cardiovascular-risk-factors
#17
Agata Stanek, Armand Cholewka, Tomasz Wielkoszyński, Ewa Romuk, Karolina Sieroń, Aleksander Sieroń
OBJECTIVE: The primary aim of the study was to assess levels of oxidative stress markers, soluble CD40 ligand (sCD40L), serum pregnancy-associated plasma protein-A (PAPP-A), and placental growth factor (PlGF) as well as carotid intima-media thickness (IMT) in patients with ankylosing spondylitis (AS) with active phase without concomitant classical cardiovascular risk factors. MATERIAL AND METHODS: The observational study involved 96 male subjects: 48 AS patients and 48 healthy ones, who did not differ significantly regarding age, BMI, comorbid disorders, and distribution of classical cardiovascular risk factors...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28871018/early-life-exposure-to-air-pollutants-and-adverse-pregnancy-outcomes-protocol-for-a-prospective-cohort-study-in-beijing
#18
Jing Song, Yi Chen, Ling Wei, Ying Ma, Ning Tian, Shi Yun Huang, Yin Mei Dai, Li Hong Zhao, Yuan Yuan Kong
INTRODUCTION: The association between early exposure to ambient air pollution and adverse pregnancy outcomes in China is unclear. This study will assess the risk of early-life exposure to air pollutants in Beijing and explore the viability of 8-hydroxydeoxyguanosine (8-OHdG) as a biological indicator to assess oxidative stress induced by early-life exposure to air pollution. METHODS AND ANALYSIS: Here, 2500 women with singleton pregnancies and their infants will be recruited from the Beijing Obstetrics and Gynecology Hospital...
September 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/28864025/birth-weight-umbilical-and-placental-traits-in-relation-to-neonatal-loss-in-cloned-pigs
#19
Zheng Ao, Dewu Liu, Chengfa Zhao, Zhimin Yue, Junsong Shi, Rong Zhou, Gengyuan Cai, Enqin Zheng, Zicong Li, Zhenfang Wu
Cloned piglets generated through somatic cell nuclear transfer (SCNT) have a high rate of neonatal death. Postnatal loss is associated with low birth weight, umbilical status and placental parameters in fertilisation-derived piglets. To investigate whether or not this relationship also exists in cloned piglets, birth weight, umbilical status, placental parameters, placental morphology and gene expression pattern were compared among four piglet groups, namely, SCNT-derived male piglets that died within 4 days (SCNT-DW4), SCNT-derived male piglets that survived over 4 days (SCNT-SO4), artificial insemination (AI)-generated male piglets that died within 4 days (AI-DW4) and AI-generated male piglets that survived over 4 days (AI-SO4)...
September 2017: Placenta
https://www.readbyqxmd.com/read/28858979/mir-195-modulates-oxidative-stress-induced-apoptosis-and-mitochondrial-energy-production-in-human-trophoblasts-via-flavin-adenine-dinucleotide-dependent-oxidoreductase-domain-containing-protein-1-and-pyruvate-dehydrogenase-phosphatase-regulatory-subunit
#20
Hao Wang, Lanmei Zhang, Xuejiang Guo, Yang Bai, Yu-Xia Li, Jiahao Sha, Chun Peng, Yan-Ling Wang, Ming Liu
OBJECTIVE: Preeclampsia is a severe pregnancy-specific syndrome defined as newly onset hypertension and proteinuria. Abnormal placental development has been generally accepted as the initial cause of the disorder. Recently, miR-195 was identified as one of the downregulated small RNAs in preeclamptic placentas. METHODS: The potential targets of miR-195 in human trophoblast cells were screened by isobaric tags for relative and absolute quantification-based mass spectrum analysis...
August 30, 2017: Journal of Hypertension
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