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https://www.readbyqxmd.com/read/29216968/gender-trouble-the-world-health-organization-the-international-statistical-classification-of-diseases-and-related-health-problems-icd-11-and-the-trans-kids
#1
Sam Winter
The World Health Organization (WHO) is revising its diagnostic manual, the International Statistical Classification of Diseases and Related Health Problems (ICD). At the time of writing, and based on recommendations from its ICD Working Group on Sexual Disorders and Sexual Health, WHO is proposing a new ICD chapter titled Conditions Related to Sexual Health, and that the gender incongruence diagnoses (replacements for the gender identity disorder diagnoses used in ICD-10) should be placed in that chapter. WHO is proposing that there should be a Gender incongruence of childhood (GIC) diagnosis for children below the age of puberty...
October 2017: Sexual Health
https://www.readbyqxmd.com/read/29216318/reproducibility-of-objectively-measured-physical-activity-and-sedentary-time-over-two-seasons-in-children-comparing-a-day-by-day-and-a-week-by-week-approach
#2
Eivind Aadland, Lars Bo Andersen, Turid Skrede, Ulf Ekelund, Sigmund Alfred Anderssen, Geir Kåre Resaland
INTRODUCTION: Knowledge of reproducibility of accelerometer-determined physical activity (PA) and sedentary time (SED) estimates are a prerequisite to conduct high-quality epidemiological studies. Yet, estimates of reproducibility might differ depending on the approach used to analyze the data. The aim of the present study was to determine the reproducibility of objectively measured PA and SED in children by directly comparing a day-by-day and a week-by-week approach to data collected over two weeks during two different seasons 3-4 months apart...
2017: PloS One
https://www.readbyqxmd.com/read/29207322/identification-of-a-vte-rich-population-in-pediatrics-critically-ill-children-with-central-venous-catheters
#3
Minh Tran, Steven L Shein, Xinge Ji, Sanjay P Ahuja
BACKGROUND: The incidence of venous thromboembolism (VTE) is rising among inpatients in US hospitals, especially among kids with central venous catheters (CVCs) in the pediatric intensive care unit (PICU). OBJECTIVES: To identify a sub-group of "VTE-rich" population among PICU children, and to assess the effect of VTE on morbidity and mortality. METHODS: Data was extracted from a multicenter Virtual PICU Database, or VPS, for children with a CVC and presence of a VTE...
November 22, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/29202090/joint-spatial-modelling-of-disease-risk-using-multiple-sources-an-application-on-hiv-prevalence-from-antenatal-sentinel-and-demographic-and-health-surveys-in-namibia
#4
D Ntirampeba, I Neema, L N Kazembe
Background: In disease mapping field, researchers often encounter data from multiple sources. Such data are fraught with challenges such as lack of a representative sample, often incomplete and most of which may have measurement errors, and may be spatially and temporally misaligned. This paper presents a joint model in the effort to deal with the sampling bias and misalignment. Methods: A joint (bivariate) spatial model was applied to estimate HIV prevalence using two sources: 2014 National HIV Sentinel survey (NHSS) among pregnant women aged 15-49 years attending antenatal care (ANC) and the 2013 Namibia Demographic and Health Surveys (NDHS)...
2017: Global Health Research and Policy
https://www.readbyqxmd.com/read/29199837/psychometric-evaluation-of-the-mini-international-neuropsychiatric-interview-for-children-and-adolescents-mini-kid
#5
Laura Duncan, Kathy Georgiades, Li Wang, Ryan J Van Lieshout, Harriet L MacMillan, Mark A Ferro, Ellen L Lipman, Peter Szatmari, Kathryn Bennett, Anna Kata, Magdalena Janus, Michael H Boyle
The goals of the study were to examine test-retest reliability, informant agreement and convergent and discriminant validity of nine DSM-IV-TR psychiatric disorders classified by parent and youth versions of the Mini International Neuropsychiatric Interview for Children and Adolescents (MINI-KID). Using samples drawn from the general population and child mental health outpatient clinics, 283 youth aged 9 to 18 years and their parents separately completed the MINI-KID with trained lay interviewers on two occasions 7 to 14 days apart...
December 4, 2017: Psychological Assessment
https://www.readbyqxmd.com/read/29198537/healthcare-utilization-and-comorbidities-associated-with-anorectal-malformations-in-the-united-states
#6
Karlo Kovacic, Sravan R Matta, Katja Kovacic, Casey Calkins, Ke Yan, Manu R Sood
OBJECTIVE: To determine nationwide prevalence and healthcare utilization in children with anorectal malformations and associated anomalies over a 6-year period. STUDY DESIGN: We used the Kids' Inpatient Database for the years 2006, 2009, and 2012 for data collection. International Classification of Diseases, Ninth Revision codes were used to identify patients with anorectal malformations and associated anomalies. RESULTS: A total of 2396 children <2 years of age with anorectal malformations were identified using weighted analysis; 54...
November 30, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29194392/a-cluster-randomized-trial-to-promote-healthy-menu-items-for-children-the-kids-choice-restaurant-program
#7
Guadalupe X Ayala, Iana A Castro, Julie L Pickrel, Shih-Fan Lin, Christine B Williams, Hala Madanat, Hee-Jin Jun, Michelle Zive
Evidence indicates that restaurant-based interventions have the potential to promote healthier purchasing and improve the nutrients consumed. This study adds to this body of research by reporting the results of a trial focused on promoting the sale of healthy child menu items in independently owned restaurants. Eight pair-matched restaurants that met the eligibility criteria were randomized to a menu-only versus a menu-plus intervention condition. Both of the conditions implemented new healthy child menu items and received support for implementation for eight weeks...
December 1, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29194282/frequency-and-characterization-of-tracheal-intubation-adverse-events-in-pediatric-sepsis
#8
Sarah K Schmidt, Lina Brou, Sara J Deakyne, Rakesh D Mistry, Halden F Scott
OBJECTIVES: Intubation in critically ill pediatric patients is associated with approximately 20% rate of adverse events, but rates in the high-risk condition of sepsis are unknown. Our objectives were to describe the frequency and characteristics of tracheal intubation adverse events in pediatric sepsis. DESIGN: Retrospective cohort study of a sepsis registry. SETTING: Two tertiary care academic emergency departments and four affiliated urgent cares within a single children's hospital health system...
November 30, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29192218/magnesium-uptake-by-connecting-fluid-phase-endocytosis-to-an-intracellular-inorganic-cation-filter
#9
Sandra H Klompmaker, Kid Kohl, Nicolas Fasel, Andreas Mayer
Cells acquire free metals through plasma membrane transporters. But, in natural settings, sequestering agents often render metals inaccessible to transporters, limiting metal bioavailability. Here we identify a pathway for metal acquisition, allowing cells to cope with this situation. Under limited bioavailability of Mg2+, yeast cells upregulate fluid-phase endocytosis and transfer solutes from the environment into their vacuole, an acidocalcisome-like compartment loaded with highly concentrated polyphosphate...
December 1, 2017: Nature Communications
https://www.readbyqxmd.com/read/29191351/how-issues-of-autonomy-and-consent-differ-between-children-and-adults-kids-are-not-just-little-people
#10
Sean Reynolds, Jane M Grant-Kels, Lionel Bercovitch
Decision making in dermatology practice with adult patients is in most cases a relatively straightforward process, involving a back-and-forth exchange of information, ideas and opinions between the physician and patient. This process is more complex in the field of pediatric dermatology. It involves the triad of the patient, parent or guardian, and physician. It utilizes a model, common to many fields in pediatrics, whereby the physician seeks to obtain informed permission from the parent with the assent of the child, all the while endeavoring to act in the best interests of the child...
November 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/29191350/teledermatology-kids-are-not-just-little-people
#11
Fludiona Naka, Hanspaul Makkar, Jun Lu
Teledermatology has emerged as a promising solution for pediatric and adult patients accessing dermatologic care in a health care environment fraught with barriers to access. Teledermatology has been extensively evaluated in terms of diagnostic accuracy, clinical outcomes, patient and provider satisfaction, and costs, relative to traditional health care delivery models. Current research indicates that teledermatology is effective and efficient in diagnosis and management of skin diseases. The majority of studies on the subject, however, rely on adult patient data...
November 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/29191349/clinical-trials-kids-are-not-just-little-people
#12
Fludiona Naka, Bruce Strober, Mona Shahriari
Clinical trials are the backbone of modern evidence-based medicine. They are the vital bridge between research-based discovery and cutting edge patient care. Randomized, controlled clinical trials are the gold standard of medical research, providing a method for evaluation and discovery of novel therapies that improve and even save lives. Despite an increase in the number of pediatric and adult clinical trials over recent decades, this growth has not been equal among these populations. The volume of clinical trials involving children lags substantially behind their adult counterparts...
November 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/29191348/cutaneous-adverse-drug-reactions-kids-are-not-just-little-people
#13
Reid Waldman, Diane Whitaker-Worth, Jane M Grant-Kels
Cutaneous adverse drug reactions are a common complication of drug therapy and affect patients of all ages. Despite the daunting frequency at which these reactions occur, there are no scientific contributions comparing cutaneous adverse drug reactions in adults to those occurring in children. Literature delineating such differences is important given that there are significant age-related differences in the pharmacokinetics of many drugs and that most of the package-insert data on adverse drug reactions are based on preclinical trials that do not include children as participants...
November 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/29191347/granulomatous-diseases-kids-are-not-just-little-people
#14
Nikita Lakdawala, Katalin Ferenczi, Jane M Grant-Kels
Granulomatous diseases represent a heterogeneous group of conditions characterized by histiocytic inflammation that affect patients of any age. These diseases differ widely in their pathogenesis and include infectious and noninfectious conditions. This review focuses on noninfectious granulomatous conditions, with particular emphasis on age-related differences in the onset, epidemiology, clinical manifestations, prognosis, and age-specific management of specific granulomatous disorders. Knowledge of age-specific aspects of granulomatous conditions in adults and children improves both the extent of the diagnostic workup and the management of these patients...
November 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/29191346/neutrophilic-dermatoses-kids-are-not-just-little-people
#15
Grace L Lee, Amy Y-Y Chen
Neutrophilic dermatoses are a group of inflammatory skin disorders characterized by an overactive innate immune system with dysregulation of neutrophils without underlying infectious etiology. The major representative conditions discussed are Sweet syndrome; pyoderma gangrenosum; neutrophilic eccrine hidradenitis; palmoplantar eccrine hidradenitis; subcorneal pustular dermatoses; bowel-associated dermatosis arthritis syndrome; and synovitis, acne, pustulosis, hyperostosis, and osteitis. We will also discuss other neutrophilic conditions present almost exclusively in the pediatric population, including congenital erosive and vesicular dermatosis with reticulated supple scarring and the recently described group of autoinflammatory diseases...
November 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/29191345/vasculitis-kids-are-not-just-little-people
#16
Nikita Lakdawala, Flavia Fedeles
Cutaneous vasculitis, inflammatory destruction of blood vessels, can present with a wide range of clinical and pathologic findings across a number of heterogeneous conditions. Although some vasculitides are present in both children and adults, some important differences exist in clinical presentation, etiology, management, and prognosis in childhood vasculitis versus adult vasculitis. Cutaneous vasculitis is rare in children, and most childhood vasculitides, of which Henoch-Schönlein purpura is the most common, histologically are small vessel leukocytoclastic vasculitis...
November 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/29191344/malignant-skin-tumors-kids-are-not-just-little-people
#17
Reid A Waldman, Jane M Grant-Kels
Skin tumors are a clinically heterogeneous group of dermatologic conditions that affect both children and adults. Although similar types of skin tumors can affect both children and adults, the epidemiology, pathogenesis, and treatment of these skin neoplasms can vary drastically in children compared with adults. Despite the clear need for literature elucidating the differences of skin tumors in children compared with adults, there is a serious dearth of scientific contributions addressing this area. This contribution highlights the types of differences that can occur between adults and children with skin neoplasms, as well as the special considerations that need to be recognized when managing skin tumors in children by providing a comparative analysis of basal cell carcinoma, squamous cell carcinoma, and Kaposi sarcoma occurring in adults with these same tumors occurring in children...
November 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/29191343/an-age-based-approach-to-dermatologic-surgery-kids-are-not-just-little-people
#18
Breton Yates, James Whalen, Hanspaul Makkar
Surgical dermatologic procedures in children pose unique challenges that differ from those in adults. Child and parental anxiety, along with procedural anxiety in adults, necessitate different approaches. Special considerations are reviewed in the application of topical anesthesia and administration of local anesthesia in children as opposed to adults, and the use and safety of general anesthesia in children is highlighted. In addition, management of postprocedural analgesia differs in children, largely due to concern for safety of opioids in children...
November 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/29191342/cutaneous-sign-of-abuse-kids-are-not-just-little-people
#19
Sphoorthi Jinna, Nina Livingston, Rebecca Moles
Skin injury is the most common form of child physical abuse. Although the pattern and visual appearance of skin injury and the treatment needed for the injury is similar in children and adults, characteristics of infant and childhood skin may complicate the diagnosis of injury. A good understanding of normal developmental presentation of accidental injury from infancy to adulthood, locations for injury that should trigger consideration of abuse, and cutaneous mimics of abuse across the lifespan are critical to the identification of suspected abuse...
November 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/29191341/approach-to-the-total-body-skin-examination-in-adults-and-children-kids-are-not-just-little-people
#20
Caroline LaRosa, Hanspaul Makkar, Jane M Grant-Kels
The indications, evidence for, and approach to performing a total body skin examination differs for adult versus pediatric patients. To provide optimal care to all of our patients, dermatologists should recognize these differences and feel comfortable and competent in performing a total body skin examination in patients of all ages.
November 2017: Clinics in Dermatology
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