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See Yenn Chong, Michael D Todd
Numerous Lamb wave dispersion curve estimation methods have been developed to support damage detection and localization strategies in non-destructive evaluation/structural health monitoring (NDE/SHM) applications. In this paper, the covariance matrix is used to extract features from an ultrasonic wavefield imaging (UWI) scan in order to estimate the phase and group velocities of S0 and A0 modes. A laser ultrasonic interrogation method based on a Q-switched laser scanning system was used to interrogate full-field ultrasonic signals in a 2-mm aluminum plate at five different frequencies...
May 1, 2018: Ultrasonics
Sergey Vinogradov, Adam Cobb, Jay Fisher
Magnetostrictive transduction has been widely utilized in nondestructive evaluation (NDE) applications, specifically for the generation and reception of guided waves for the long-range inspection of components such as pipes, vessels, and small tubes. Transverse-motion guided wave modes (e.g., torsional vibrations in pipes) are the most common choice for long-range inspection applications, because the wave motion is in the plane of the structure surface, and therefore does not couple well to the surrounding material...
May 8, 2018: Materials
Hua Wang, Anzari Atik, Tessandra Stewart, Carmen Ginghina, Patrick Aro, Kathleen F Kerr, John Seibyl, Danna Jennings, Poul Henning Jensen, Kenneth Marek, Min Shi, Jing Zhang
Plasma total and nervous system derived exosomal (NDE) α-synuclein have been determined as potential biomarkers of Parkinson's disease (PD). To explore the utility of plasma α-synuclein in the prodromal phase of PD, plasma total and NDE α-synuclein were evaluated in baseline and 2-year follow-up samples from 256 individuals recruited as part of the Parkinson's Associated Risk Syndrome (PARS) study. The results demonstrated that baseline and longitudinal increases in total α-synuclein predicted progression of cognitive decline in hyposmic individuals with dopamine transporter (DAT) binding reduction...
April 26, 2018: Neurobiology of Disease
Dana Chesney
Individual differences in the ability to compare and evaluate nonsymbolic numerical magnitudes-approximate number system (ANS) acuity-are emerging as an important predictor in many research areas. Unfortunately, recent empirical studies have called into question whether a historically common ANS-acuity metric-the size of the numerical distance effect (NDE size)-is an effective measure of ANS acuity. NDE size has been shown to frequently yield divergent results from other ANS-acuity metrics. Given these concerns and the measure's past popularity, it behooves us to question whether the use of NDE size as an ANS-acuity metric is theoretically supported...
April 12, 2018: Attention, Perception & Psychophysics
Francesco Simonetti, Isaak L Satow, Alex J Brath, Kaden C Wells, John Porter, Brian Hayes, Kenneth Davis
Recent advances in computational methods, materials science, and new manufacturing processes are resulting in an unprecedented design flexibility which is driving the geometrical complexity of the components found in modern structures and machines. For safety-critical components, the geometrical complexity poses a significant challenge to the sensitivity of the existing nondestructive evaluation (NDE) methods available for the detection of manufacturing defects or damage that develops while a component is in service...
April 2018: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
Jaydeep Yadav, Ken Korzekwa, Swati Nagar
Time-dependent inactivation (TDI) of CYPs is a leading cause of clinical drug-drug interactions (DDIs). Current methods tend to over-predict DDIs. In this study, a numerical approach was used to model complex CYP3A TDI in human liver microsomes. Inhibitors evaluated include troleandomycin (TAO), erythromycin (ERY), verapamil (VER) and diltiazem (DTZ) along with primary metabolites N-demethyl erythromycin (NDE), norverapamil (NV), and N-desmethyl diltiazem (NDD). Complexities incorporated in the models included multiple binding kinetics, quasi-irreversible inactivation, sequential metabolism, inhibitor depletion, and membrane partitioning...
April 2, 2018: Molecular Pharmaceutics
Sajan Shrestha, Sourav Banerjee
In this article, a generalized computational method to simulate virtual nondestructive evaluation (NDE) of anisotropic composite plates is presented. The ultrasonic wave fields were computed using a modified and generalized version of Distributed Point Source Method (DPSM), a semi-analytical mesh-free technique. The anisotropic Green's functions required for DPSM implementation were calculated using Fourier transform method and Radon transform method and compared. It is established that the Green's functions obtained from two different methods are identical...
March 5, 2018: Ultrasonics
Samuel Che Nde, Manny Mathuthu
The concentration of potential toxic elements (PTEs) in the Upper Crocodile river catchment area in North-west Province, South Africa, was investigated. Water and sediment samples were collected among different land uses in the upper Crocodile River catchment area and analysed using inductively-coupled plasma-mass spectrometry (ICP-MS). Several guidelines were used to gauge the level of contamination and possible toxic effect of PTEs. The physicochemical analysis showed that electrical conductivity (EC), pH, and total dissolved solids (TDS) values complied with the recommended values of Department of Water and Forestry (DWAF) guidelines for South Africa...
March 23, 2018: International Journal of Environmental Research and Public Health
E Nji Nde Aboringong, Alain M Dikandé
The amide-I [Formula: see text] -helix protein is a long molecular chain made up of regularly spaced peptide groups interacting via C=O bonds. According to the current theory the energy released by hydrolyzed adenosine triphosphate is carried across the protein via vibration modes, caused by C=O bond stretchings which, in the presence of anharmonic molecular vibrations, can promote nonlinear localized excitations called excitons. In this work the effects of long-range interactions between amide-I molecules on the modulational instability of small-amplitude excitons, and on characteristic parameters of soliton wavetrain-type excitons, are investigated with emphasis on long-range interactions saturating at finite intermolecular interaction ranges...
March 21, 2018: European Physical Journal. E, Soft Matter
Chantal Beatrice Magne Nde, Gloria Casas Gimeno, Maria Docanto, Kevin C Knower, Morag J Young, Jakob Buehn, Edris Sayed, Colin D Clyne
Activation of oestrogen receptor α (ERα) stimulates cell division and tumour growth by modulating the expression of ERα target genes. This activation involves the recruitment of specific proteins with activities that are still not fully understood. Timeless, the human homologue of the Drosophila gene involved in circadian rhythm, was previously shown to be a strong predictor of tamoxifen relapse, and is involved in genomic stability and cell cycle control. In this study, we investigated the interplay between Timeless and ERα, and showed that human Timeless is an ERα coactivator...
March 16, 2018: Journal of Molecular Biology
Rachel A Hoopsick, D Lynn Homish, Paul T Bartone, Gregory G Homish
Background: Much research has focused on stress related to deployments; however, a substantial proportion of soldiers never deploy. In a study of 1.3 million veterans, suicide risk was higher among veterans who had never deployed. Thus, not being deployed may have an impact on soldiers' well-being; however, no measures exist to assess emotions regarding non-deployment. We aimed to develop and test an original measure of non-deployment emotions. Methods: We examined the Non-Deployment Emotions (NDE) questionnaire, a novel four-item measure of guilt, unit value, unit camaraderie, and unit connectedness in a sample of never-deployed male and female US Army Reserve/National Guard (USAR/NG) soldiers (N = 174)...
March 14, 2018: Military Medicine
Francesca Pistoia, Giulia Mattiacci, Marco Sarà, Luca Padua, Claudio Macchi, Simona Sacco
Near-death experiences (NDEs) have been defined as any conscious perceptual experience occurring in individuals pronounced clinically dead or who came very close to physical death. They are frequently reported by patients surviving a critical injury and, intriguingly, they show common features across different populations. The tool traditionally used to assess NDEs is the NDE Scale, which is available in the original English version. The aim of this study was to develop the Italian version of the NDE Scale and to assess its reliability in a specific clinical setting...
2018: Frontiers in Human Neuroscience
Joyce B Foryoung, Chobufo Ditah, Peter Nde Fon, Yannick Mboue-Djieka, Daniel N Nebongo, Noel D Mbango, Vanessa Balla, Simeon-Pierre Choukem
OBJECTIVES: There are limited data on mortality in patients with type 2 diabetes mellitus (T2DM) in Sub-Saharan Africa. We aimed at determining the mortality rate, and the causes and the predictors of death in patients with T2DM followed as outpatients in a reference hospital in Cameroon. DESIGN: Retrospective cohort study. SETTING: A reference hospital in Cameroon. PARTICIPANTS: From December 2015 to March 2016, patients with T2DM aged 18 years and older and who consulted between January 2009 and December 2014, were contacted directly or through their next of kin, and included in this study...
February 22, 2018: BMJ Open
Kristen P Morie, Jia Wu, Nicole Landi, Marc N Potenza, Linda C Mayes, Michael J Crowley
Impaired cognitive control is a consequence of cocaine exposure. Difficulty with feedback processing may underlie this impairment. We examined neural correlates of feedback processing using event-related potentials (ERPs) in 49 prenatally cocaine-exposed (PCE) and 34 nondrug exposed (NDE) adolescents. Adolescents performed a reward-feedback task with win/no-win feedback in a chance-based task. We investigated amplitude and latency of the feedback-related negativity (FRN) and P300 ERP components and source-based estimates elicited during feedback processing...
2018: Developmental Neuropsychology
Helena Cassol, Benoît Pétré, Sophie Degrange, Charlotte Martial, Vanessa Charland-Verville, François Lallier, Isabelle Bragard, Michèle Guillaume, Steven Laureys
Near-death experiences (NDEs) refer to profound psychological events that can have an important impact on the experiencers' (NDErs) lives. Previous studies have shown that NDEs memories are phenomenologically rich. In the present study, we therefore aimed to extract the common themes (referred to as "features" in the NDE literature) reported by NDErs by analyzing all the concepts stored in the narratives of their experiences. A qualitative thematic analysis has been carried out on 34 cardiac arrest survivors' NDE narratives...
2018: PloS One
Chathurani Ranathunge, Gregory L Wheeler, Melody E Chimahusky, Meaghan M Kennedy, Jesse I Morrison, Brian S Baldwin, Andy D Perkins, Mark E Welch
The mechanisms by which natural populations generate adaptive genetic variation are not well understood. Some studies propose that microsatellites can function as drivers of adaptive variation. Here, we tested a potentially adaptive role for transcribed microsatellites with natural populations of the common sunflower (Helianthus annuus L.) by assessing the enrichment of microsatellites in genes that show expression divergence across latitudes. Seeds collected from six populations at two distinct latitudes in Kansas and Oklahoma were planted and grown in a common garden...
March 2018: Molecular Ecology
Francisco Hernando Quintanilla, Cara A C Leckey
The growing use of composite materials for aerospace applications has resulted in a need for quantitative nondestructive evaluation (NDE) methods appropriate for characterizing damage in composite components. NDE simulation tools, such as ultrasound models, can aid in enabling optimized inspection methods and establishing confidence in inspection capabilities. In this paper a mathematical approach using the Lebedev Finite Difference (LFD) method is presented for ultrasonic wave simulation in composites. Boundary condition equations for implementing stress-free boundaries (necessary for simulation of NDE scenarios) are also presented...
May 2018: Ultrasonics
Pei Wang, Peng Zhang, Gui-Wen Wu, Shang-Qing Hu, Jing Li, Jun-Jun Sun, Ya-Feng Wang, Min-Yi Zhao, Ni-Juan Hu, Jiang Zhu
OBJECTIVE: To observe the analgesic effect of deqi induced by needling at Sanyinjiao (SP 6) on primary dysmenorrheal (PD) patients with cold damp stagnation syndrome (CDSS). METHODS: A total of 64 PD patients with CDSS experiencing abdominal pain (≥40 mm in visual analogue scale ,VAS) were randomly assigned into deqi -expectation(DE) group( n =15) and no- deqi -expectation(NDE) group( n =49). On the first day of abdominal pain attack, bilateral SP 6 were punctured respectively with thicker needles with deeper insertion for deqi -expectation patients and thin filiform needles with shallow insertion for no- deqi -expectation patients...
January 25, 2018: Zhen Ci Yan Jiu, Acupuncture Research
David Royse, Karen Badger
Persons who come close to death but survive catastrophic accidents sometimes report very vivid experiences during times when their survival was in doubt, when they were believed to be dead, and during resuscitation efforts. This qualitative study builds upon existing research on near-death experiences (NDEs) by focusing on the oral accounts from a sample of individuals with large and life-threatening burns. The NDE accounts were obtained from burn survivors attending the Phoenix Society's World Burn Congress and are similar to reports by notable researchers ( Greyson, 2003 ; Moody, 1975 ; Ring, 1980 ) while reflecting the uniqueness of the individual survivor's experiences...
January 1, 2018: Omega
Subir Patra, Hossain Ahmed, Sourav Banerjee
Peridynamic based elastodynamic computation tool named Peri-elastodynamics is proposed herein to simulate the three-dimensional (3D) Lamb wave modes in materials for the first time. Peri-elastodynamics is a nonlocal meshless approach which is a scale-independent generalized technique to visualize the acoustic and ultrasonic waves in plate-like structure, micro-electro-mechanical systems (MEMS) and nanodevices for their respective characterization. In this article, the characteristics of the fundamental Lamb wave modes are simulated in a sample plate-like structure...
January 18, 2018: Sensors
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