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Nicholas J Bradshaw, Mirian A F Hayashi
NDE1 (Nuclear Distribution Element 1, also known as NudE) and NDEL1 (NDE-Like 1, also known as NudEL) are the mammalian homologues of the fungus nudE gene, with important and at least partially overlapping roles for brain development. While a large number of studies describe the various properties and functions of these proteins, many do not directly compare the similarities and differences between NDE1 and NDEL1. Although sharing a high degree structural similarity and multiple common cellular roles, each protein presents several distinct features that justify their parallel but also unique functions...
October 14, 2016: Cellular and Molecular Life Sciences: CMLS
Adama Diouf, Mbeugué Thiam, Nicole Idohou-Dossou, Ousmane Diongue, Ndé Mégné, Khady Diallo, Pape Malick Sembène, Salimata Wade
Background: Physical inactivity and sedentary lifestyles are major risk factors of childhood obesity. This study aimed to measure physical activity (PA) levels by accelerometer and Physical Activity Questionnaire for Older Children (PAQ-C) among Senegalese school children and the relation with Body Mass Index (BMI) and body composition. Methodology: 156 pupils 8-11 years old were randomly selected in four elementary public schools of Dakar. BMI z-score was used to categorize children according to their weight status...
October 10, 2016: International Journal of Environmental Research and Public Health
Qiana L Matthews, Anitra L Farrow, Girish Rachakonda, Linlin Gu, Pius Nde, Alexandre Krendelchtchikov, Siddharth Pratap, Shruti S Sakhare, Steffanie Sabbaj, Maria F Lima, Fernando Villalta
BACKGROUND: Previously we reported that a hexon-modified adenovirus (Ad) vector containing the invasive neutralizing epitope of Trypanosoma cruzi (T. cruzi) trypomastigote gp83 (Ad5-gp83) provided immunoprotection against T. cruzi infection. The purpose of this work was to design an improved vaccine for T. cruzi using a novel epitope capsid incorporation strategy. Thus, we evaluated the immunoprotection raised by co-immunization with Ad5-gp83 and an Ad vector containing an epitope (ASP-M) of the T...
October 2016: Pathogens & Immunity
Liang Zeng, Jing Lin, Liping Huang, Ming Zhao
Besides the phase and group velocities, the amplitude of guided wave mode is also frequency dependent. This amplitude dispersion also influences the performance of guided wave methods in nondestructive evaluation (NDE) and structural health monitoring (SHM). In this paper, the effects of amplitude dispersion to the spectrum and waveform of a propagating wave-packet are investigated. It is shown that the amplitude dispersion results in distortion in the spectrum of guided wave response, and thus influences the waveform of the wave-packet...
September 30, 2016: Sensors
Nicolas Quaegebeur, Nidhal Bouslama, Maxime Bilodeau, Robin Guitel, Patrice Masson, Ahmed Maslouhi, Philippe Micheau
Validation of guided-wave based systems for Non-Destructive Evaluation (NDE) and Structural Health Monitoring (SHM) under realistic conditions or environment requires complex setups. For this purpose, numerical or theoretical approaches are useful to save time and cost associated with experiential tests. However, the interaction with realistic geometrical (rivets, thickness changes, stiffeners, extrusions) or damage features (fatigue cracks, fillet cracks, delaminations, disbonds) must be accurately captured in order to be representative...
September 14, 2016: Ultrasonics
Edward J Goetzl, Dimitrios Kapogiannis, Janice B Schwartz, Iryna V Lobach, Laura Goetzl, Erin L Abner, Gregory A Jicha, Anna M Karydas, Adam Boxer, Bruce L Miller
Synaptic dysfunction occurs early in senile dementias, presumably as a result of decreased levels of functional synaptic proteins as found in autopsied brains of patients with Alzheimer's disease (AD) or frontotemporal dementia (FTD). Plasma neuronal-derived exosomes (NDEs) were recovered by precipitation and immunoabsorption from 12 patients with AD, 16 with FTD, and 28 controls in a cross-sectional study, and from 9 patients with AD, 10 with FTD, and 19 controls in a longitudinal study. Six synaptic proteins in NDE extracts were quantified by ELISAs and normalized for exosome amounts...
September 6, 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Dickson Shey Nsagha, Innocent Lange, Peter Nde Fon, Jules Clement Nguedia Assob, Elvis Asangbeng Tanue
BACKGROUND: HIV and AIDS are major public health problems in the world and Africa. In Cameroon, the HIV prevalence is 5.1%. Cellphones have been found to be useful in the provision of modern health care services using short message services (SMS). This study assessed the effectiveness of SMS in improving the adherence of people living with HIV and AIDS to their treatment and care in Cameroon. METHODS: This intervention study used a randomized controlled trial design...
2016: Open AIDS Journal
Divine B Nde, Dorin Boldor, Carlos Astete, Pranjali Muley, Zhimin Xu
Shea butter, is highly solicited in cosmetics, pharmaceuticals, chocolates and biodiesel formulations. Microwave assisted extraction (MAE) of butter from sheanut kernels was carried using the Doehlert's experimental design. Factors studied were microwave heating time, temperature and solvent/solute ratio while the responses were the quantity of oil extracted and the acid number. Second order models were established to describe the influence of experimental parameters on the responses studied. Under optimum MAE conditions of heating time 23 min, temperature 75 °C and solvent/solute ratio 4:1 more than 88 % of the oil with a free fatty acid (FFA) value less than 2, was extracted compared to the 10 h and solvent/solute ratio of 10:1 required for soxhlet extraction...
March 2016: Journal of Food Science and Technology
Iraklis Vastardis, Brigitte Pajic-Eggspühler, Jörg Müller, Zeljka Cvejic, Bojan Pajic
PURPOSE: To report the visual outcomes of the femtosecond laser-assisted multifocal aspheric corneal ablation profile using a mini-monovision approach and to evaluate if corneal multifocality was effective, and to report the relative benefits of this approach. PATIENTS AND METHODS: Bilateral femtosecond laser-assisted in situ keratomileusis using a multifocal aspheric corneal ablation profile was performed on 19 hyperopic patients (38 eyes). They were divided into two groups based on eye dominance: dominant eye (DE) group targeting emmetropia and the nondominant eye (NDE) group targeting -0...
2016: Clinical Ophthalmology
Buh Amos Wung, Nde Fon Peter, Julius Atashili
BACKGROUND: Clients have explicit desires or requests for services when visiting hospitals; inadequate discovery of their needs may result in dissatisfaction. Patient satisfaction influences retention in HIV care, adherence to HAART and serves as determinant to HIV suppression. This study's objectives were to quantify clients' satisfaction with HIV services in Bamenda and determine relationship between satisfaction and clients' socio-demographic/structural characteristics. METHODS: A cross-sectional study was conducted on HIV-positive patients followed-up, on treatment and who consulted in the Bamenda Regional Hospital treatment centre between July and August 2014...
2016: BMC Health Services Research
Charisse N Winston, Edward J Goetzl, Johnny C Akers, Bob S Carter, Edward M Rockenstein, Douglas Galasko, Eliezer Masliah, Robert A Rissman
INTRODUCTION: Levels of Alzheimer's disease (AD)-related proteins in plasma neuronal derived exosomes (NDEs) were quantified to identify biomarkers for prediction and staging of mild cognitive impairment (MCI) and AD. METHODS: Plasma exosomes were extracted, precipitated, and enriched for neuronal source by anti-L1CAM antibody absorption. NDEs were characterized by size (Nanosight) and shape (TEM) and extracted NDE protein biomarkers were quantified by ELISAs. Plasma NDE cargo was injected into normal mice, and results were characterized by immunohistochemistry to determine pathogenic potential...
2016: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
Floren Rubio, Edward D Blandford, Leonard J Bond
Ultrasonics has been used in many industrial applications for both sensing at low power and processing at higher power. Generally, the high power applications fall within the categories of liquid stream degassing, impurity separation, and sonochemical enhancement of chemical processes. Examples of such industrial applications include metal production, food processing, chemical production, and pharmaceutical production. There are many nuclear process streams that have similar physical and chemical processes to those applications listed above...
September 2016: Ultrasonics
Christopher W Kahler, Tao Liu, Patricia A Cioe, Vaughn Bryant, Megan M Pinkston, Erna M Kojic, Nur Onen, Jason V Baker, John Hammer, John T Brooks, Pragna Patel
In a cohort of patients receiving care for HIV, we examined longitudinally the impact of past 30-day frequency of heavy drinking (consuming 5+ drinks on one occasion) on HIV-related (detectable viral load and CD4+ T cell count) and non-HIV-related (hemoglobin and biomarkers of kidney function and liver fibrosis) clinical outcomes and the extent to which these effects were due to reduced antiretroviral therapy (ART) adherence. Data came from the Study to Understand the Natural History of HIV/AIDS in the Era of Effective Therapy...
July 8, 2016: AIDS and Behavior
Gui Yun Tian, Yunlai Gao, Kongjing Li, Yizhe Wang, Bin Gao, Yunze He
This paper reviews recent developments of eddy current pulsed thermography (ECPT) for material characterization and nondestructive evaluation (NDE). Due to the fact that line-coil-based ECPT, with the limitation of non-uniform heating and a restricted view, is not suitable for complex geometry structures evaluation, Helmholtz coils and ferrite-yoke-based excitation configurations of ECPT are proposed and compared. Simulations and experiments of new ECPT configurations considering the multi-physical-phenomenon of hysteresis losses, stray losses, and eddy current heating in conjunction with uniform induction magnetic field have been conducted and implemented for ferromagnetic and non-ferromagnetic materials...
2016: Sensors
Nallely Mora, William H Adams, Stephanie Kliethermes, Lara Dugas, Neelam Balasubramanian, Jasmin Sandhu, Helen Nde, Christina Small, Joanne Jose, Steven Scaglione, Jennifer E Layden
BACKGROUND: Hepatitis C (HCV) is a deleterious virus that can be cured with new, highly effective anti-viral treatments, yet more than 185 million individuals worldwide remain HCV positive (with the vast majority un-diagnosed or untreated). Of importance, HCV is a leading cause of chronic liver disease and liver cancer, especially in Sub-Saharan Africa (SSA) where the prevalence remains high but uncertain due to little population-based evidence of the epidemic. We aimed to synthesize available data to calculate and highlight the HCV disease burden in SSA...
2016: BMC Infectious Diseases
Jules Kehbila, Cyril Jabea Ekabe, Leopold Ndemnge Aminde, Jean Jacques N Noubiap, Peter Nde Fon, Gottlieb Lobe Monekosso
BACKGROUND: Tuberculosis (TB) remains a global health challenge and depression is a significant contributor to the global burden of disease. Current evidence suggests that there is an association between depressive symptoms and TB, lower adherence to treatment, and increased morbidity and mortality. However, there is paucity of data regarding these associations in Cameroon. This study aimed to determine the prevalence and correlates of depression in adult patients with pulmonary TB (PTB) in the Southwest Region of Cameroon...
2016: Infectious Diseases of Poverty
Stéphane Zingue, Julia Cisilotto, Alain Brice Tueche, Anupam Bishayee, Francine Azegha Mefegue, Louis Pergaud Sandjo, Chantal Beatrice Magne Nde, Evelyn Winter, Thomas Michel, Derek Tantoh Ndinteh, Charline Florence Awounfack, Kevine Kamga Silihe, Tito Tresor Melachio Tanekou, Tânia Beatriz Creczynski-Pasa, Dieudonné Njamen
ETHNOPHARMACOLOGICAL RELEVANCE: Crateva adansonii DC is a plant traditionally used in Cameroon to treat constipation, asthma, snakebites, postmenopausal complaints and cancers. AIM: The anticancer potential of the dichloromethane/methanol extract of C. adansonii stem barks was investigated using human breast cancer cell and 7,12 dimethylbenz(a)anththracene (DMBA)-induced mammary tumorigenesis model in rats. MATERIAL AND METHODS: The cytotoxicity of C...
August 22, 2016: Journal of Ethnopharmacology
Yun Lu, Hongwei Li, Shi-Wei Shen, Zhen-Hai Shen, Ming Xu, Cheng-Jian Yang, Feng Li, Yin-Bo Feng, Jing-Ting Yun, Ling Wang, Hua-Jin Qi
BACKGROUND: It has been shown that irisin levels are reduced in skeletal muscle and plasma of obese rats; however, the effect of exercise training on irisin level remains controversial. We aim to evaluate the association of swimming exercise with serum irisin level and other obesity-associated parameters. METHODS: Forty healthy male Wistar rats were randomly assigned to 4 groups: a normal diet and sedentary group (ND group), normal diet and exercise group (NDE group), high-fat diet and sedentary group (HFD group), and high-fat diet and exercise group (HFDE group...
2016: Lipids in Health and Disease
Yanfeng Shen, Victor Giurgiutiu
Lamb waves have been widely explored as a promising inspection tool for non-destructive evaluation (NDE) and structural health monitoring (SHM). This article presents a combined analytical finite element model (FEM) approach (CAFA) for the accurate, efficient, and versatile simulation of 2-D Lamb wave propagation and interaction with damage. CAFA used a global analytical solution to model wave generation, propagation, scattering, mode conversion, and detection, while the wave-damage interaction coefficients (WDICs) were extracted from harmonic analysis of local FEM with non-reflective boundaries (NRB)...
July 2016: Ultrasonics
Andrews Marques do Nascimento, Ewelyne Miranda de Lima, Girlandia Alexandre Brasil, Izabela Facco Caliman, Josiane Fernandes da Silva, Virgínia Soares Lemos, Tadeu Uggere de Andrade, Nazaré Souza Bissoli
UNLABELLED: Anabolic-androgenic steroids are misused, including by women, but little is known about the cardiovascular effects of these drugs on women. AIM: To evaluated the effects of nandrolone decanoate (ND) and resistive physical exercise on cardiac contractility in young female rats. MAIN METHODS: Female Wistar rats were separated into 4 groups: C (untrained animals); E (animals were submitted to resistance exercise by jumping in water 5 times per week); ND (animals were treated with ND, 20mg/kg/week for 4weeks); and NDE (trained and treated)...
June 15, 2016: Toxicology and Applied Pharmacology
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