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Bone turnover markers

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https://www.readbyqxmd.com/read/28448762/bone-turnover-in-osteoporotic-women-during-long-term-oral-bisphosphonates-treatment-implications-for-treatment-failure-and-drug-holiday-in-the-real-world
#1
Yair Liel, Ygal Plakht, Muhammad Abu-Tailakh
OBJECTIVE: Little data exists to support concerns over bone turnover suppression during prolonged oral bisphosphonates treatment and on consequences of the recommended "drug holiday". This study was set to assess bone resorption rates in postmenopausal osteoporotic women on prolonged oral bisphosphonates treatment, and in response to switching to "drug holiday", intravenous bisphosphonate or continuation of oral bisphosphonates. METHODS: Frequency distribution of the bone resorption marker urinary deoxypyridinoline cross-links (uDPD), was obtained retrospectively from 211 osteoporotic women attended at an academic hospital endocrine clinic, treated for >2 years with oral bisphosphonates...
April 27, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28448457/effects-of-vitamin-d-supplementation-on-bone-turnover-markers-a-randomized-controlled-trial
#2
Verena Schwetz, Christian Trummer, Marlene Pandis, Martin R Grübler, Nicolas Verheyen, Martin Gaksch, Armin Zittermann, Winfried März, Felix Aberer, Angelika Lang, Gerlies Treiber, Claudia Friedl, Barbara Obermayer-Pietsch, Thomas R Pieber, Andreas Tomaschitz, Stefan Pilz
Bone turnover markers (BTMs) are used to evaluate bone health together with bone mineral density and fracture assessment. Vitamin D supplementation is widely used to prevent and treat musculoskeletal diseases but existing data on vitamin D effects on markers of bone resorption and formation are inconsistent. We therefore examined the effects of vitamin D supplementation on bone-specific alkaline phosphatase (bALP), osteocalcin (OC), C-terminal telopeptide (CTX), and procollagen type 1 N-terminal propeptide (P1NP)...
April 27, 2017: Nutrients
https://www.readbyqxmd.com/read/28444666/markers-of-bone-and-cartilage-turnover
#3
Henning W Woitge, Markus J Seibel
Over the past few decades, scientists have been trying to identify tissue-specific markers that would help to better understand the pathogenesis of bone and cartilage diseases and could be used clinically for the screening, diagnosis and follow-up of bone or joint diseases. Historically, only a few components known to be involved in bone, mineral or cartilage turnover were available for this purpose (e. g., urine hydroxyproline, serum and urine calcium and phosphate levels). However, since most if not all of these substances have wider biological functions beyond bone, mineral and cartilage metabolism, their clinical value as tissue-specific markers was limited...
April 25, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28440741/standardized-rat-model-testing-effects-of-inflammation-and-grafting-on-extraction-healing
#4
Emily S Willett, Jingpeng Liu, Molly Berke, Peter J Giannini, Marian Schmid, Zhenshan Jia, Xiaobei Wang, Xiaoyan Wang, Kaeli Samson, Fang Yu, Dong Wang, Ali Nawshad, Richard A Reinhardt
BACKGROUND: Loss of the alveolar ridge width and height following tooth extraction is well-documented, but models to evaluate ridge preservation are neither standardized nor cost-effective. This rat model characterizes the pattern of bone turnover and inflammation after extraction and bone grafting with or without local simvastatin (SIM). METHODS: Fifty retired-breeder rats underwent extraction of the right maxillary first molar and standard surgical defect creation under inhalation/local anesthesia...
April 25, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28439619/association-between-bone-mineral-density-muscle-strength-and-vitamin-d-status-in-patients-with-myasthenia-gravis-a-cross-sectional-study
#5
Y Guan, F Lv, Y Meng, D Ma, X Xu, Y Song, O Wang, Y Jiang, W Xia, X Xing, J Zhang, M Li
Myasthenia gravis (MG) patients had low proximal hip BMD, which could be explained by reduced muscle strength, elevated bone resorption markers, vitamin D deficiency, and increased PTH levels in those with MG compared to controls. INTRODUCTION: Muscle strength is closely correlated with bone mineral density (BMD) and vitamin D status. Here, we evaluated muscle strength, BMD, and vitamin D status in a large sample of Chinese patients with MG. METHODS: In this cross-sectional survey, 86 patients with MG without glucocorticoid treatment and 86 healthy controls were included...
April 24, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28439050/-calcium-and-bone-metabolism-across-women-s-life-stages-changes-of-biochemical-markers-of-bone-turnover-in-life-cycle-of-women
#6
Osamu Chaki
Development of bone metabolism markers began about 35 years ago. Current by the osteoporosis and bone metabolism diseases diagnosis and treatment efficacy. In childhood and adolescence, bone formation and resorption were increased, but formation rate was exceeded resorption rate. To keep strength of bone, bone formation and resorption are balanced(remodeling)in the period of maturity, Bone mineral density greatly decreases and biochemical markers of bone turnover markedly increase in postmenopausal women, indicating accelerated bone remodeling because of estrogen withdrawal...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28429554/is-there-a-practical-role-for-bone-biopsy-in-chronic-kidney-disease
#7
Terrence Diamond, Grahame J Elder
Bone biopsy is currently the only means to accurately assess renal osteodystrophy and responses to therapeutic interventions. With sedation, the technique is relatively painless, and complications are uncommon. Bone biopsy should be considered when the aetiology of symptoms or biochemical abnormalities is in question, and results may lead to changes in therapy. Although it remains prudent to use antiresorptive drugs cautiously in patients with chronic kidney disease (CKD) stages 3a-4 and low bone mineral density, bone biopsy may not be warranted before commencing therapy in these patients...
March 2017: Nephrology
https://www.readbyqxmd.com/read/28429547/the-use-of-bone-turnover-markers-in-chronic-kidney-disease-mineral-and-bone-disorders
#8
Cherie Chiang
Bone turnover markers assist in fracture risk prediction, management and monitoring of osteoporosis in patients without chronic kidney disease (CKD). The use in CKD-mineral bone disorder (MBD) has been limited as many of these markers and breakdown products are renally excreted, including the most commonly used and well standardized procollagen type I N propeptide and C-terminal cross-linking telopeptide of type I collagen. Of the markers unaffected by renal function, bone specific alkaline phosphatase is associated with mortality and fracture rate in CKD subjects and is now available on several automated analysers...
March 2017: Nephrology
https://www.readbyqxmd.com/read/28425581/clinical-biochemical-and-genetic-features-of-41-han-chinese-families-with-primary-hypertrophic-osteoarthropathy-and-their-therapeutic-response-to-etoricoxib-results-from-a-6-months-prospective-clinical-intervention
#9
Shan-Shan Li, Jin-We He, Wen-Zhen Fu, Yu-Juan Liu, Yun-Qiu Hu, Zhen-Lin Zhang
Primary hypertrophic osteoarthropathy (PHO) is a rare inherited disease caused by genetic defects in prostaglandin metabolism pathway; disturbed prostaglandin E2 (PGE2 ) catabolism resulting in increased PGE2 levels is suggested in the pathogenesis. Forty-three Han Chinese patients with PHO were studied and 41 of them were treated. Mutations in HPGD gene, causing hypertrophic osteoarthropathy, primary, autosomal recessive 1 (PHOAR1; OMIM 259100), were identified in 7 patients, and mutations in SLCO2A1 gene, causing hypertrophic osteoarthropathy, primary, autosomal recessive 2 (PHOAR2; OMIM 614441), were identified in 36 patients...
April 20, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28414058/assessment-of-bone-turnover-markers-to-predict-mineral-and-bone-disorder-in-men-with-pre-dialysis-non-diabetic-chronic-kidney-disease
#10
Joseph Jessy Davina, M Priyadarssini, Medha Rajappa, Sreejith Parameswaran, Jayaprakash Sahoo, P S Mohan Raj, G Revathy, C Palanivel, Marie Gilbert Marella
BACKGROUND: Chronic kidney disease (CKD) is commonly associated with disturbances in mineral metabolism and bone disease. Bone biopsy is the gold standard in diagnosing mineral bone disorder. Hence the search for non-invasive assessment of bone health gains importance. We undertook to assess the bone health in men with stage 4 and 5 chronic kidney Disease. METHODS: We recruited 32 male subjects with Stage 4 and 5 chronic kidney disease and 32 age-matched healthy male controls...
April 14, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28408276/low-serum-concentrations-of-irisin-are-associated-with-increased-risk-of-hip-fracture-in-chinese-older-women
#11
Jun Yan, Hai-Juan Liu, Wei-Chun Guo, Jian Yang
OBJECTIVE: Irisin derived from muscle in response to exercise may be the molecular entity responsible for muscle wasting-osteoporosis connectivity in the elderly. The objective of the study was to determine whether serum Irisin (sIrisin) provides information on hip fracture prediction which were independent of bone mineral density (BMD) and the fracture risk assessment tool (FRAX) algorithm. METHODS: This study enrolled 160 older women (ages, 70-90 y) with minimal trauma hip fractures (MTHFs) and 160 age-matched women without fracture serving as controls...
April 10, 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/28407138/calcium-and-bone-turnover-markers-in-acromegaly-a-prospective-controlled-study
#12
Tina Constantin, Vin Tangpricha, Reshma Shah, Nelson M Oyesiku, Octavian C Ioachimescu, James Ritchie, Adriana G Ioachimescu
Context: Acromegaly has been associated with calcium-phosphate and bone turnover alterations. Controlled studies of these interactions are sparse. Objective: To evaluate calcium and bone metabolism in active and treated acromegaly. Design/Setting/Patients: We conducted a controlled prospective study at a tertiary referral center. We studied 22 patients with acromegaly referred for surgical or medical therapy (ACM) and 22 with nonfunctioning pituitary adenomas referred for surgery (control)...
April 12, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28406904/relationship-between-bone-turnover-and-left-ventricular-function-in-primary-hyperparathyroidism-the-epath-trial
#13
Nicolas Verheyen, Astrid Fahrleitner-Pammer, Evgeny Belyavskiy, Martin R Gruebler, Hans Peter Dimai, Karin Amrein, Klemens Ablasser, Johann Martensen, Cristiana Catena, Elisabeth Pieske-Kraigher, Caterina Colantonio, Jakob Voelkl, Florian Lang, Ioana Alesutan, Andreas Meinitzer, Winfried März, Helmut Brussee, Burkert Pieske, Stefan Pilz, Andreas Tomaschitz
Observational studies suggested a link between bone disease and left ventricular (LV) dysfunction that may be pronounced in hyperparathyroid conditions. We therefore aimed to test the hypothesis that circulating markers of bone turnover correlate with LV function in a cohort of patients with primary hyperparathyroidism (pHPT). Cross-sectional data of 155 subjects with pHPT were analyzed who participated in the "Eplerenone in Primary Hyperparathyroidism" (EPATH) Trial. Multivariate linear regression analyses with LV ejection fraction (LVEF, systolic function) or peak early transmitral filling velocity (e', diastolic function) as dependent variables and N-terminal propeptide of procollagen type 1 (P1NP), osteocalcin (OC), bone-specific alkaline phosphatase (BALP), or beta-crosslaps (CTX) as the respective independent variable were performed...
2017: PloS One
https://www.readbyqxmd.com/read/28397581/comparison-of-the-effects-of-denosumab-with-either-active-vitamin-d-or-native-vitamin-d-on-bone-mineral-density-and-bone-turnover-markers-in-postmenopausal-osteoporosis
#14
Takako Suzuki, Yukio Nakamura, Mizue Tanaka, Mikio Kamimura, Shota Ikegami, Shigeharu Uchiyama, Hiroyuki Kato
Osteoporosis is a worldwide health concern. Although treatment with denosumab plus the active vitamin D alfacalcidol has been found to improve femoral neck (FN) and distal forearm bone mineral density (BMD), there have been no reports on the efficacy or adverse effects of denosumab plus eldecalcitol (ELD) in primary osteoporosis patients. Fifty-six treatment-naïve post-menopausal women with primary osteoporosis were recruited and divided into denosumab plus native vitamin D or denosumab plus ELD. Ultimately, 26 subjects in the native vitamin D group and 24 in the ELD group were analyzed...
April 11, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28388781/effects-of-hypertrophy-exercise-in-bone-turnover-markers-and-structure-in-growing-male-rats
#15
Elena Nebot, Virginia A Aparicio, Peter Pietschmann, Daniel Camiletti-Moirón, Garyfallia Kapravelou, Reinhold G Erben, Rosario Martínez, Cristina Sánchez-González, Jesús M Porres, Juan Llopis, María López-Jurado, Pilar Aranda
The benefits of exercise on bone density, structure and turnover markers are rather controversial. The present study aimed to examine the effects of hypertrophy exercise (HE) on bone. 20 male Wistar rats were randomly distributed in 2 experimental groups, one performing HE and the other untrained over 12 weeks. Plasma parameters, bone mineral content, bone mineral density (BMD), structure, and trabecular and cortical microarchitecture were measured. Femur Mg content was 12% higher (p<0.001), whereas femur length, dry weight, P content, and aminoterminal propeptides of type I procollagen were lower in the HE group (all, p<0...
April 7, 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28384008/high-dietary-alpha-tocopherol-or-mixed-tocotrienols-have-no-effect-on-bone-mass-density-or-turnover-in-male-rats-during-skeletal-maturation
#16
Katherine G Tennant, Scott W Leonard, Carmen P Wong, Urszula T Iwaniec, Russell T Turner, Maret G Traber
High levels of alpha-tocopherol, the usual vitamin E supplement, are reported to decrease bone mass in rodents; however, the effects of other vitamin E forms on the skeleton are unknown. To test the hypothesis that high intakes of various vitamin E forms or the vitamin E metabolite, carboxyethyl hydroxy chromanol, were detrimental to bone status, Sprague-Dawley rats (n = 6 per group, 11-week males) for 18 weeks consumed semipurified diets that contained adequate alpha-tocopherol, high alpha-tocopherol (500 mg/kg diet), or 50% Tocomin (250 mg mixed tocopherols and tocotrienols/kg diet)...
April 6, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28382553/circulating-periostin-levels-increase-in-association-with-bone-density-loss-and-healing-progression-during-the-early-phase-of-hip-fracture-in-chinese-older-women
#17
J Yan, H J Liu, H Li, L Chen, Y Q Bian, B Zhao, H X Han, S Z Han, L R Han, D W Wang, X F Yang
The present study shows that hip fracture women had higher serum periostin (sPostn) levels. The elevation of sPostn is associated with bone density loss, yet fracture itself may even increase sPostn levels during early healing phase. INTRODUCTION: The study aims to quantify the associations of sPostn levels with bone density loss and the possible effect on the fracture healing. METHODS: This study enrolled 261 older women with osteoporotic hip fracture and 106 age-matched women without fracture serving as controls...
April 5, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28378291/vibrational-spectroscopic-techniques-to-assess-bone-quality
#18
REVIEW
E P Paschalis, S Gamsjaeger, K Klaushofer
Although musculoskeletal diseases such as osteoporosis are diagnosed and treatment outcome is evaluated based mainly on routine clinical outcomes of bone mineral density (BMD) by DXA and biochemical markers, it is recognized that these two indicators, as valuable as they have proven to be in the everyday clinical practice, do not fully account for manifested bone strength. Thus, the term bone quality was introduced, to complement considerations based on bone turnover rates and BMD. Bone quality is an "umbrella" term that incorporates the structural and material/compositional characteristics of bone tissue...
April 5, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28378072/interleukin-6-gene-polymorphism-in-patients-with-degenerative-lumbar-scoliosis-a-cohort-study
#19
Jung Sub Lee, Jong Ki Shin, Tae Sik Goh
PURPOSE: Low bone mass and a female gender increase susceptibility to the development of degenerative lumbar scoliosis (DLS), which suggests the potential involvement of an osteoporosis-related gene in the pathogenesis of DLS. In the present study, the authors studied the relations between polymorphisms of interleukin 6 (IL-6) gene and DLS in a patient cohort. METHODS: In 184 patients with a diagnosis of DLS, the authors determined the presence of the -597 G/A, -572 G/C, and -174 G/C polymorphisms, measured bone mineral densities at the lumbar spine (LSBMD) and femoral neck (FNBMD), assessed radiological findings including lumbar scoliosis and lateral listhesis, investigated biochemical markers of bone turnover, and compared these results obtained with those of 220 healthy normal controls...
April 4, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28373598/raccoon-dog-model-shows-preservation-of-bone-during-prolonged-catabolism-and-reduced-physical-activity
#20
Anne-Mari J Mustonen, Mikko A J Finnilä, Katri S Puukka, Timo J Jämsä, Simo Saarakkala, Juha K Tuukkanen, T Petteri Nieminen
The raccoon dog (Nyctereutes procyonoides) is a promising animal model capable of preventing disuse-induced osteoporosis. Previous data suggest that this species resembles bears in the preservation of bone mass and biomechanical properties during prolonged passivity and catabolism. This longitudinal study examined the osteological properties of tibiae in farm-bred raccoon dogs that were either fed or fasted (n=6/group) for a 10-week period. Peripheral quantitative computed tomography was utilized and plasma markers of bone turnover measured before fasting and at 9 weeks followed by mechanical testing (three-point bending), micro-computed tomography and Fourier transform infrared imaging at 10 weeks...
April 3, 2017: Journal of Experimental Biology
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