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Bone turnover markers

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https://www.readbyqxmd.com/read/28640843/metabolic-milieu-associates-with-impaired-skeletal-characteristics-in-obesity
#1
Heli T Viljakainen, Heikki A Koistinen, Taina Tervahartiala, Timo Sorsa, Sture Andersson, Outi Mäkitie
High leptin concentration, low-grade inflammation, and insulin resistance often coexist in obese subjects; this adverse metabolic milieu may be the main culprit for increased fracture risk and impaired bone quality seen in patients with type 2 diabetes. We examined the associations of leptin, hs (high sensitivity)- CRP and insulin resistance with bone turnover markers (BTMs) and bone characteristics in 55 young obese adults (median BMI 40 kg/m2) and 65 non-obese controls. Mean age of the subjects was 19.5 ± 2...
2017: PloS One
https://www.readbyqxmd.com/read/28640230/total-flavonoids-of-drynariae-rhizoma-prevent-bone-loss-induced-by-hindlimb-unloading-in-rats
#2
Shuanghong Song, Ziyang Gao, Xujun Lei, Yinbo Niu, Yuan Zhang, Cuiqin Li, Yi Lu, Zhezhi Wang, Peng Shang
Drynariae Rhizoma is a kidney-tonifying herb that has a long history in clinical practice for the treatment of bone fractures and joint diseases in China. Flavonoids are considered to be its major active ingredients and are reported to ease bone loss in ovariectomized rats. However, the beneficial effects of the total flavonoids of Drynariae Rhizoma on osteoporosis caused by microgravity or mechanical inactivity remain unknown. This study assessed the effects of total Drynariae Rhizoma flavonoids (DRTF, Qihuang, Beijing, China, national medicine permit No...
June 22, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28638864/protective-effect-of-vanillic-acid-on-ovariectomy-induced-osteoporosis-in-rats
#3
Yong Gui Wang, Liang Bo Jiang, Bo Gou
BACKGROUND: The need for an anti-osteoporotic agent is in high demand since osteoporosis contributes to high rates of disability or impairment (high osteoporotic fracture), morbidity and mortality. Hence, the present study is designed to evaluate the protective effects of vanillic acid (VA) against bilateral ovariectomy-induced osteoporosis in female Sprague-Dawley (SD) rats. MATERIALS AND METHODS: Forty healthy female adult SD rats were separated in to four groups with sham-operated control with bilateral laprotomy (Sham; n = 10), bilateral overiectomy (OVX; n = 10) group, OVX rats were orallay administrated with 50 mg/kg b...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28634697/in-psoriatic-arthritis-dkk-1-and-pth-are-lower-than-in-rheumatoid-arthritis-and-healthy-controls
#4
Angelo Fassio, Luca Idolazzi, Ombretta Viapiana, Camilla Benini, Elisabetta Vantaggiato, Francesco Bertoldo, Maurizio Rossini, Davide Gatti
Psoriatic Arthritis (PsA) is characterized by bone erosive damage often associated with exuberant bone formation especially in enthesial sites. Dkk-1 and sclerostin are the main inhibitors of the WNT/β-catenin signaling pathway and play a key role in the regulation of both bone formation and resorption. We performed this study in order to compare the serum levels of the WNT-pathway regulators along with bone turnover markers (BTM) and parathyroid hormone (PTH) between three different groups: one group of female patients affected by PsA, one group of female patients affected by rheumatoid arthritis (RA), and healthy female controls (HC)...
June 20, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28631236/use-of-ctx-i-and-pinp-as-bone-turnover-markers-national-bone-health-alliance-recommendations-to-standardize-sample-handling-and-patient-preparation-to-reduce-pre-analytical-variability
#5
P Szulc, K Naylor, N R Hoyle, R Eastell, E T Leary
N-terminal propeptide of type I procollagen and C-terminal telopeptide of type I collagen are the reference standards for bone turnover markers for monitoring osteoporosis treatment. We provide recommendations for standardized sample handling and encompassing aspects of preanalytical variability to improve the reproductibility of their measurements, their reliability, and clinical interpretation. The International Osteoporosis Foundation and International Federation of Clinical Chemistry bone turnover marker standards working group have identified N-terminal propeptide of type I procollagen (PINP) and C-terminal telopeptide of type I collagen (CTX-I) in the blood to be the international reference standards for bone turnover markers for the prediction of fracture risk and monitoring of osteoporosis treatment...
June 19, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28629592/measurement-and-clinical-utility-of-%C3%AE-ctx-in-serum-and-plasma
#6
Stephen A P Chubb, Samuel D Vasikaran
Biochemical markers of bone turnover (BTM) are released during bone remodeling and can be measured in blood or urine as noninvasive surrogate markers for the bone remodeling rate. The C-terminal cross-linked telopeptide of type I collagen (βCTX) is released during bone resorption and is specific to bone tissue. Assays have been developed to measure βCTX in blood and in urine; most current use of βCTX measurement for research and in clinical practice is performed on a blood sample. Method-specific differences for serum and plasma βCTX have led to initiatives to standardize or harmonize βCTX commercial assays...
2017: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/28627829/mir-29a-and-messenger-rna-expression-of-bone-turnover-markers-in-canonical-wnt-pathway-in-patients-with-ankylosing-spondylitis
#7
Jinxian Huang, Guoxiang Song, Zhihua Yin, Zhongchao Fu, Zhizhong Ye
BACKGROUND: Recent studies showed that the canonical Wnt pathway and miR-29a play important roles in the pathogenesis of bone formation. We studied the levels of miR-29a and messenger RNA (mRNA) of bone turnover markers in the canonical Wnt pathway in ankylosing spondylitis (AS). METHODS: The levels of miR-29a and mRNA of bone turnover markers in canonical Wnt pathway from peripheral blood mononuclear cells were determined by real-time quantitative polymerase chain reaction in 38 patients with AS and 32 healthy controls...
May 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28624935/eldecalcitol-an-active-vitamin-d3-derivative-prevents-trabecular-bone-loss-and-bone-fragility-in-type-i-diabetic-model-rats
#8
Satoshi Takeda, Mitsuru Saito, Sadaoki Sakai, Kenji Yogo, Keishi Marumo, Koichi Endo
Diabetes mellitus is known to adversely affect the bones and be associated with increased fracture risk. We examined whether eldecalcitol (ELD), an active vitamin D3 derivative, could inhibit the diabetic bone loss in streptozotocin-induced type I diabetic rats. ELD (10, 20, or 40 ng/kg), alfacalcidol (ALF; 25, 50, or 100 ng/kg), or vehicle was administered 5 times per week for 12 weeks from 1 week after diabetes induction. Normal control rats received the vehicle. Bone turnover markers, bone mineral density (BMD), and biomechanical strength of the lumbar spine and femur were measured, and bone histomorphometry was performed...
June 17, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28608802/enhanced-osteogenic-differentiation-in-zoledronate-treated-osteoporotic-patients
#9
Luca Dalle Carbonare, Monica Mottes, Giovanni Malerba, Antonio Mori, Martina Zaninotto, Mario Plebani, Alessandra Dellantonio, Maria Teresa Valenti
Bisphosphonates are well known inhibitors of osteoclast activity and thus may be employed to influence osteoblast activity. The present study was designed to evaluate the in vivo effects of zoledronic acid (ZA) on the proliferation and osteoblastic commitment of mesenchymal stem cells (MSC) in osteoporotic patients. We studied 22 postmenopausal osteoporotic patients. Densitometric, biochemical, cellular and molecular data were collected before as well as after 6 and 12 months of ZA treatment. Peripheral blood MSC-like cells were quantified by colony-forming unit fibroblastic assay; their osteogenic differentiation potential was evaluated after 3 and 7 days of induction, respectively...
June 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28606219/dietary-calcium-intake-and-rate-of-bone-loss-in-men
#10
Sarah M Bristow, Gregory D Gamble, Anne M Horne, Ian R Reid
A high Ca intake has been recommended for osteoporosis prevention; however, little research has examined the relationship between dietary Ca and bone health in men. We examined associations between dietary Ca intake, bone mineral density (BMD) and change in BMD at the total body, hip and spine over 2 years in a cohort of men (mean age 57 years, BMI 26 kg/m2) from a trial. Data from the total cohort (n 323) were used in the analysis of Ca intake and BMD at baseline, and data from the placebo group (n 99) were used in the longitudinal analysis of Ca intake and change in BMD...
June 13, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28603900/mitochondrial-point-mutation-m-3243a%C3%A2-%C3%A2-g-associates-with-lower-bone-mineral-density-thinner-cortices-and-reduced-bone-strength-a-case-control-study
#11
Jakob Høgild Langdahl, Anja Lisbeth Frederiksen, Stinus Jørn Hansen, Per Heden Andersen, Knud Bonnet Yderstraede, Morten Dunø, John Vissing, Morten Frost
Mitochondrial dysfunction is associated with several clinical manifestations including diabetes, neurological disorders, renal and hepatic diseases and myopathy. While mitochondrial dysfunction is associated with increased bone resorption and decreased bone formation in mouse models, effects of alterations in mitochondrial function on bone remodelling and mass have not been investigated in humans. We recruited 45 carriers (29 females, 16 males) with the m.3243A > G mutation and healthy controls matched for gender, age, height and menopausal status...
June 11, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28601248/evaluation-of-bone-turnover-markers-and-serum-minerals-variations-for-predicting-fracture-healing-versus-non-union-processes-in-adult-sheep-as-a-model-for-orthopedic-research
#12
Cristina P Sousa, Mónica Lopez-Peña, Fernando M Guzón, Humberto V De Abreu, Maurino R Luís, Carlos A Viegas, José Camassa, Jorge T De Azevedo, António S Cabrita, Rui L Reis, Manuela E Gomes, Isabel R Dias
Bone turnover markers (BTMs) have been considered as an auxiliary method of following the fracture healing process and for early prediction of impaired bone healing. A better understanding of the potential of BTMs in this application could allow for earlier interventions and improved patient care. The aim of this study with a large animal experimental model was to assess the variation of bone formation markers - namely the total alkaline phosphatase (ALP) and its bone-specific isoform (BALP), serum concentration of intact osteocalcin (OC), N-terminal propeptide type III procollagen (PIIINP) and of bone resorption markers - namely tartrate resistant acid phosphatase (TRAP) and deoxypyridinoline crosslink (DPD) during the first stages of a normal fracture healing process and of a segmental critical size defect (CSD), which progresses to a non-union process...
May 17, 2017: Injury
https://www.readbyqxmd.com/read/28593655/vitamin-d-levels-strongly-influence-bone-mineral-density-and-bone-turnover-markers-during-weight-gain-in-female-patients-with-anorexia-nervosa
#13
Alessandro Giollo, Luca Idolazzi, Cristian Caimmi, Angelo Fassio, Francesco Bertoldo, Riccardo Dalle Grave, Marwan El Ghoch, Simona Calugi, Paola Vittoria Bazzani, Ombretta Viapiana, Maurizio Rossini, Davide Gatti
OBJECTIVE: The aim of the study was to investigate a potential role for vitamin D status on bone mineral density (BMD) during weight gain in patients with anorexia nervosa (AN). METHOD: Spine and hip BMD assessed by dual-energy X-ray absorptiometry (DXA), serum vitamin D (25-OH-D), N-propeptide of type I collagen (P1NP), C-terminal telopeptide of type I collagen (CTX), and intact parathyroid hormone (PTH) were measured before and after a 20-week intensive weight-restoration program in ninety-one female patients with AN and secondary amenorrhoea...
June 7, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/28587403/effects-of-1-25-dihydroxyvitamin-d3-on-the-local-bone-renin-angiotensin-system-in-a-murine-model-of-glucocorticoid-induced-osteoporosis
#14
Lin Shen, Chen Ma, Bo Shuai, Yanping Yang
Active vitamin D is closely related to the circulating renin-angiotensin system (RAS) in experimental animal models and humans; however, corresponding local bone data remain limited. The present study examined whether 1,25-dihydroxyvitamin D3 supplementation altered local bone RAS elements in a murine model of glucocorticoid-induced osteoporosis (GIOP). A total of 36 8-week-old mice were randomized into three equal-sized groups: The sham, GIOP and 1,25-dihydroxyvitamin D3 treatment groups. After 12 weeks, the cancellous bone microstructure of the third lumbar vertebra and left femur from the mice from each group were examined using micro-computed tomography...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28580511/effect-of-recent-spinal-cord-injury-on-the-opg-rankl-system-and-its-relationship-with-bone-loss-and-the-response-to-denosumab-therapy
#15
L Gifre, S Ruiz-Gaspà, J L Carrasco, E Portell, J Vidal, A Muxi, A Monegal, N Guañabens, P Peris
There is marked bone loss after spinal cord injury (SCI); however, its pathogenesis and clinical management remain unclear. The increased circulating levels of receptor activator of nuclear factor kB ligand (RANKL) associated with bone loss shortly after SCI and the prevention of bone loss with denosumab treatment suggest a contributory role of RANKL in SCI-induced osteoporosis. INTRODUCTION: Bone turnover and bone loss are markedly increased shortly after SCI. However, the pathogenesis and clinical management of this process remain unclear, especially the role of the osteoprotegerin (OPG)/RANKL system in this disorder...
June 4, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28580395/effects-of-total-flavonoids-from-drynariae-rhizoma-prevent-bone-loss-in-vivo-and-in-vitro
#16
Shuang-Hong Song, Yuan-Kun Zhai, Cui-Qin Li, Qian Yu, Yi Lu, Yuan Zhang, Wen-Ping Hua, Zhe-Zhi Wang, Peng Shang
Estrogen deficiency is one of the major causes of osteoporosis in postmenopausal women. Drynariae Rhizoma is a widely used traditional Chinese medicine for the treatment of bone diseases. In this study, we investigated the therapeutic effects of the total Drynariae Rhizoma flavonoids (DRTF) on estrogen deficiency-induced bone loss using an ovariectomized rat model and osteoblast-like MC3T3-E1 cells. Our results indicated that DRTF produced osteo-protective effects on the ovariectomized rats in terms of bone loss reduction, including decreased levels of bone turnover markers, enhanced biomechanical femur strength and trabecular bone microarchitecture deterioration prevention...
December 2016: Bone Reports
https://www.readbyqxmd.com/read/28573777/once-weekly-administration-of-a-long-acting-fgf21-analogue-modulates-lipids-bone-turnover-markers-blood-pressure-and-body-weight-differently-in-obese-hypertriglyceridemic-subjects-and-in-non-human-primates
#17
Albert M Kim, Veena R Somayaji, Jennifer Q Dong, Timothy P Rolph, Yan Weng, Jeffrey R Chabot, Kathryn E Gropp, Saswata Talukdar, Roberto A Calle
AIMS: To assess the safety, tolerability, pharmacokinetics and pharmacodynamics of PF-05231023, a long-acting FGF21 analogue, in obese, hypertriglyceridemic subjects on atorvastatin with or without type 2 diabetes. METHODS: Subjects received PF-05231023 or placebo intravenously once-weekly for 4 weeks. Safety (12-lead electrocardiogram [ECGs], vital signs, adverse events [AEs], laboratory tests) and longitudinal weight assessments were performed. Blood samples were collected for pharmacokinetic and pharmacodynamic analyses...
June 1, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28560474/vertebral-fracture-in-postmenopausal-chinese-women-a-population-based-study
#18
L Cui, L Chen, W Xia, Y Jiang, L Cui, W Huang, W Wang, X Wang, Y Pei, X Zheng, Q Wang, Z Ning, M Li, O Wang, X Xing, Q Lin, W Yu, X Weng, L Xu, S R Cummings
In a random sample of postmenopausal Chinese women, the prevalence of radiographic vertebral fractures increased from 13% between ages 50 and 59 to over 50% after age 80 years. A model with seven clinical risk factors predicted the probability of vertebral fractures as well with as without BMD and better than a model with only three risk factors. More than half an hour of outdoor activity per day might correlate with lower risk of vertebral fracture in this population. INTRODUCTION: We aimed to describe the prevalence and develop a model for prediction of radiographic vertebral fractures in a large random sample of postmenopausal Chinese women...
May 30, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28555718/bone-turnover-with-venlafaxine-treatment-in-older-adults-with-depression
#19
Kerri S Rawson, David Dixon, Roberto Civitelli, Tim R Peterson, Benoit H Mulsant, Charles F Reynolds, Eric J Lenze
OBJECTIVES: Epidemiologic data suggest older adults receiving serotonergic antidepressants may have accelerated bone loss. We examined bone turnover marker changes and patient-level variables associated with these changes in older adults receiving protocolized antidepressant treatment. DESIGN: Open-label, protocolized treatment study. SETTING: Medical centers in Pittsburgh, St Louis, and Toronto. PARTICIPANTS: Older adults with major depression (N = 168)...
May 26, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28555285/association-of-adiposity-indices-with-bone-density-and-bone-turnover-in-the-chinese-population
#20
J Wang, D Yan, X Hou, P Chen, Q Sun, Y Bao, C Hu, Z Zhang, W Jia
Associations of adiposity indices with bone mineral density (BMD) and bone turnover markers were evaluated in Chinese participants. Body mass index, fat mass, and lean mass are positively related to BMD in both genders. Subcutaneous fat area was proved to be negatively associated with BMD and positively correlated with osteocalcin in postmenopausal females. INTRODUCTION: Obesity is highly associated with osteoporosis, but the effect of adipose tissue on bone is contradictory. Our study aimed to assess the associations of adiposity indices with bone mineral density (BMD) and bone turnover markers (BTMs) in the Chinese population...
May 29, 2017: Osteoporosis International
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