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Bone turnover markers

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https://www.readbyqxmd.com/read/29149352/prognostic-potential-of-markers-of-bone-turnover-in-delayed-healing-tibial-diaphyseal-fractures
#1
Malhar Kumar, Dnyaneshwar Shelke, Saumil Shah
INTRODUCTION: Clinical and radiographic examinations detect delayed or nonunion only after the event has occurred. Biochemical markers of bone turnover (BTMs) are promising laboratory tools that offer an early insight into the likelihood of delayed union. We hypothesized that BTMs display temporal variations following fractures and the behavior of BTMs differ between normal and delayed union of fractures. METHODS: This was a prospective study of patients with closed fracture of tibia treated with intramedullary, interlocking nailing...
November 17, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/29144812/increased-bone-turnover-in-type-2-diabetes-patients-randomized-to-bariatric-surgery-vs-medical-therapy-at-5-years
#2
Megan R Crawford, Nathan Pham, Leila Khan, James F Bena, Philip R Schauer, Sangeeta R Kashyap
OBJECTIVE: The aim of our study was to determine the 5 year outcomes of bariatric surgery vs. intensive medical therapy on bone turnover in patients with type 2 diabetes (T2DM) from the STAMPEDE trial. METHODS: This is an ancillary investigation of a 5 year randomized control trial at a single tertiary care center involving 95 patients aged 48.5 ± 8 years with obesity (BMI: 36.5±3.6 kg/m(2)) and uncontrolled T2DM (HbA1C: 9.3 ±1.6%). Patients were randomized to intensive medical therapy (IMT; N=25), Roux-en-Y gastric bypass (RYGB; N=37), or sleeve gastrectomy (SG; N=33) for diabetes treatment...
November 16, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29144808/osteoporotic-fractures-during-bisphosphonate-drug-holiday-fractures-bisphosphonate-drug-holidays
#3
Brittany Bindon, William Adams, Neelam Balasubramanian, Jasmin Sandhu, Pauline Camacho
OBJECTIVE: Bisphosphonate (BP) drug holidays are recommended to lower the risk of rare adverse events, such as atypical femoral fractures and osteonecrosis of the jaw. However, there are minimal data on the optimal duration of these holidays. Our aim was to determine the clinical and laboratory parameters associated with increased fracture risk in patients on BP drug holiday. METHODS: A retrospective chart review was conducted of 401 patients with osteopenia or osteoporosis who began a BP drug holiday from 2004 to 2013...
November 16, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29143804/telomeres-and-telomerase-in-hematopoietic-dysfunction-prognostic-implications-and-pharmacological-interventions
#4
REVIEW
Theresa Vasko, Andrea Kaifie, Matthias B Stope, Thomas Kraus, Patrick Ziegler
Leukocyte telomere length (TL) has been suggested as a marker of biological age in healthy individuals, but can also reflect inherited and acquired hematopoietic dysfunctions or indicate an increased turnover of the hematopoietic stem and progenitor cell compartment. In addition, TL is able to predict the response rate of tyrosine kinase inhibitor therapy in chronic myeloid leukemia (CML), indicates clinical outcomes in chronic lymphocytic leukemia (CLL), and can be used as screening tool for genetic sequencing of selected genes in patients with inherited bone marrow failure syndromes (BMFS)...
October 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29143140/impact-of-conventional-medical-therapy-on-bone-mineral-density-and-bone-turnover-in-adult-patients-with-x-linked-hypophosphatemia-a-6-year-prospective-cohort-study
#5
Vikram Vinod Shanbhogue, Stinus Hansen, Niklas Rye Jørgensen, Signe Sparre Beck-Nielsen
X-linked hypophosphatemia (XLH) is a rare, inheritable disorder manifesting as rickets in children and osteomalacia in adults. While conventional medical treatment with oral phosphate and alfacalcidol is recommended in childhood, it is undecided whether adults should continue therapy. The aim of this 6-year prospective study was to determine the impact of conventional medical treatment on areal bone mineral density (aBMD), bone turnover markers (BTMs) and measures of calcium homeostasis in 27 adult patients with XLH, 11 of whom received medical treatment...
November 15, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/29138210/what-happens-after-menopause-wham-protocol-for-a-prospective-multicentre-age-matched-cohort-trial-of-risk-reducing-bilateral-salpingo-oophorectomy-in-high-risk-premenopausal-women
#6
Martha Hickey, Alison Trainer, Sabine Braat, Mary-Ann Davey, Efrosinia Krejany, John Wark
INTRODUCTION: Women at high inherited risk of ovarian cancer are advised to undergo risk-reducing bilateral salpingo-oophorectomy (RRBSO) at age 40-45 years or when their families are complete. Most women are premenopausal at this age, so RRBSO will induce surgical menopause. Despite the clear benefits of RRBSO for cancer risk reduction, much less is known about the impact on non-cancer outcomes that contribute to health and well-being and inform surveillance and management strategies...
November 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/29134242/serum-parathyroid-hormone-is-associated-with-increased-cortical-porosity-of-the-inner-transitional-zone-at-the-proximal-femur-in-postmenopausal-women-the-troms%C3%A3-study
#7
M Osima, T T Borgen, M Lukic, G Grimnes, R M Joakimsen, E F Eriksen, Å Bjørnerem
Serum parathyroid hormone (PTH) was associated with increased bone turnover markers and cortical porosity of the inner transitional zone at the proximal femur. These results suggest that PTH through increased intracortical bone turnover leads to trabecularisation of inner cortical bone in postmenopausal women. INTRODUCTION: Vitamin D deficiency leads to secondary hyperparathyroidism and increased risk for fractures, whereas its association with cortical porosity is less clear. We tested (i) whether serum 25-hydroxyvitamin D (25(OH)D) and PTH were associated with cortical porosity and (ii) whether the associations of 25(OH)D) and PTH with fracture risk are dependent on cortical porosity...
November 14, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29133976/bisphosphonates-atherosclerosis-and-vascular-calcification-update-and-systematic-review-of-clinical-studies
#8
REVIEW
Carla Caffarelli, Andrea Montagnani, Ranuccio Nuti, Stefano Gonnelli
Background: Epidemiologic and clinical data have suggested the existence of a biologic linkage between the bone system and the vascular system. Bisphosphonates (BPs) are effective inhibitors of bone resorption and are currently considered the drugs of choice for the prevention and treatment of osteoporosis and related fractures. Data from several publications have suggested that BPs may also be effective in reducing the atherosclerotic process and vascular calcification, but the results of these studies are contrasting...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29133833/effect-of-soy-on-bone-turn-over-markers-in-men-with-type-2-diabetes-and-hypogonadism-a-randomised-controlled-study
#9
T Sathyapalan, M Aye, A S Rigby, W D Fraser, E S Kilpatrick, S L Atkin
Type 2 diabetes (T2DM) is associated with increased risk of fractures. Soy supplementation has been shown to have a beneficial effect on bone turnover markers (BTM) in postmenopausal women. However, the effect of soy supplementation on BTM in T2DM and particularly in men is unclear. We performed an analysis of a randomized double blind parallel study of 200 men with T2DM treated with soy, either with or without isoflavones. Outcome measures were type I collagen crosslinked beta C-telopeptide (βCTX), and type 1 procollagen-N-propeptide (P1NP)...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29129760/the-key-role-of-proinflammatory-cytokines-matrix-proteins-rankl-opg-and-wnt-%C3%AE-catenin-in-bone-healing-of-hip-arthroplasty-patients
#10
Jean Cassuto, Agnetha Folestad, Jan Göthlin, Henrik Malchau, Johan Kärrholm
INTRODUCTION: We still lack understanding of why some implants fail while most remain stable after decades of use. Proinflammatory cytokines, matrix proteins and bone regulating cytokines of the RANKL/OPG (receptor activator of nuclear factor kappa B ligand/osteoprotegerin) and Wnt/β-catenin pathways are mandatory for normal bone repair but their spatial and temporal role in the healing of primary total hip arthroplasties (THA) has not been previously shown. MATERIALS AND METHODS: Twenty-four osteoarthritis patients with one-sided well-fixed primary THA were prospectively monitored during 18years (18Y) with repeated blood samples, clinical variables and radiographs...
November 9, 2017: Bone
https://www.readbyqxmd.com/read/29124433/positive-association-between-serum-uric-acid-and-bone-mineral-density-in-chinese-type-2-diabetes-mellitus-stratified-by-gender-and-bmi
#11
Mingxin Xu, Junlei Su, Jie Hao, Ni Zhong, Zhiyin Zhang, Ran Cui, Feng Li, Chunjun Sheng, Ge Zhang, Hui Sheng, Shen Qu
Accumulating evidence has demonstrated that serum uric acid (UA), a natural powerful antioxidant, plays a beneficial role in bone health in the general population. However, few reports are available on the association between serum UA and bone in patients with type 2 diabetes mellitus (T2DM). We therefore investigated whether the benefit of serum UA for bone health was still present in those patients. 626 males and 609 postmenopausal females with T2DM were enrolled in this cross-sectional study. Serum UA concentrations and bone mineral density (BMD) measured at lumbar spine, femoral neck and total hip by dual-energy X-ray absorptiometry were obtained from all subjects...
November 9, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29123427/effect-of-age-and-estrogen-on-biochemical-markers-of-bone-turnover-in-postmenopausal-women-a-population-based-study-from-nepal
#12
Bashu Dev Pardhe, Sabala Pathak, Anjeela Bhetwal, Sumitra Ghimire, Shreena Shakya, Puspa Raj Khanal, Sujan Babu Marahatta
Background: Osteoporosis, a common disease worldwide, is characterized by low bone mass and architectural deterioration of bone tissue, leading to enhanced bone fragility and increase in fracture risks. Both menopause and aging are related factors leading to greater risk of bone disease, particularly among postmenopausal women. Hence, the main purpose of this study was to investigate the differences in biochemical markers of bone turnover and to evaluate the association of hormones and age-related factors with biochemical markers between pre- and postmenopausal women...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/29120659/-antidiabetic-drugs-and-their-effect-on-bone
#13
Peter Jackuliak, Martin Kužma, Juraj Payer
It is well established that osteoporosis and diabetes are prevalent diseases with significant associated morbidity and mortality. Patients with diabetes mellitus are at an increased risk of bone fractures. Today we have several groups of effective and save antidiabetic drugs, which are very given often in combination. Although diabetes-related complications are important in the etiology, the effects of medications on bone metabolism and fracture risk should not be neglected, because the diabetes medication may affect also bone health and fracture risk...
2017: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29120655/-bone-quality-in-patients-with-acromegaly
#14
Martin Kužma, Ivana Ságová, Dušan Pavai, Peter Jackuliak, Zdenko Killinger, Peter Vaňuga, Juraj Payer
The impact of acromegaly on bone and the risk of fractures has not been sufficiently investigated. GH hypersecretion stimulates bone turnover, leading to an increase in bone turnover markers. Normal or even increased bone mineral density (BMD) in comparison to healthy controls have been reported, but there are some works where decreased BMD was observed among acromegaly patients with hypogonadism, particularly at lumbar spine. Less pronounced effect of GH overproduction was observed at the femoral neck, as explained by the positive effect of hypersecretion on the cortical bone (due to periosseal ossification)...
2017: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29120134/bone-mineral-density-in-relation-to-metabolic-syndrome-components-in-postmenopausal-women-with-diabetes-mellitus-type-2
#15
Ines Bilić-Ćurčić, Sandra Makarović, Ivan Mihaljević, Maja Franceschi, Tomislav Jukić
Diabetes mellitus type 2 is associated with greater bone mineral density (BMD) due to obesity, although rapid bone loss observed over time could be explained by elevated chronic inflammation. The objective of this study was to investigate the relationship between central adiposity and hyperinsulinemia, as well as inflammation markers with vertebral and femoral BMD and bone turnover markers in postmenopausal women with type 2 diabetes. Femoral and vertebral BMD, osteocalcin, pyrilinks D, beta-CrossLaps (B-CTx), insulin, C-reactive protein (CRP), fibrinogen and plasminogen activator inhibitor-1 (PAI-1) were measured in 114 postmenopausal female patients with diabetes type 2...
March 2017: Acta Clinica Croatica
https://www.readbyqxmd.com/read/29112186/connection-between-bone-remodeling-and-inflammatory-markers-in-obstructive-sleep-apnea-in-relation-to-disease-severity
#16
Barbara Bromińska, Ewa Cyrańska-Chyrek, Barbara Kuźnar-Kamińska, Magdalena Kostrzewska, Hanna Winiarska, Nadia Sawicka-Gutaj, Ariadna Zybek-Kocik, Aleksandra Hernik, Elżbieta Wrotkowska, Zbigniew Krasiński, Marek Ruchała, Halina Batura-Gabryel
INTRODUCTION    There is growing evidence that obstructive sleep apnea (OSA) influences both bone metabolism and structure. Chitinase-3-like protein 1 (YKL-40) is a novel inflammatory and remodeling marker, which was shown to increase in OSA. YKL-40 can probably alter the bone turnover.   OBJECTIVES    Assessment of a possible interplay between YKL-40 and bone turnover markers in patients with different stages of OSA. Evaluation of the relation among bone mass, OSA severity, and YKL-40 level. PATIENTS AND METHODS    The study is based on 72 male OSA patients divided into three groups according to disease severity using apnea-hypopnea index (AHI): OSA 1 n = 18 (5 ≤ AHI < 15), OSA 2 n = 25 (15 ≤ AHI < 30), OSA 3 n = 29 (AHI ≥ 30)...
November 7, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/29105864/study-of-bone-metabolism-and-angiogenesis-in-patients-undergoing-high-dose-chemotherapy-autologous-hematopoietic-stem-cell-transplantation
#17
Georgios Boutsikas, Evangelos Terpos, Athanasios Papatheodorou, Pantelis Tsirkinidis, Panayiotis Tsirigotis, Anastasia Meletiou, Eleni Lalou, Vasileios Telonis, Anna Zannou, Alexander Kanellopoulos, Zacharoula Galani, Angeliki Stefanou, Panayiotis Tsaftaridis, Nora-Athina Viniou, Panayiotis Panayiotidis, Marie-Christine Kyrtsonis, John Meletis, Theodoros P Vassilakopoulos, Maria K Angelopoulou
OBJECTIVES: Since the interaction between Hematopoietic Stem Cells (HSCs) and endosteal and endothelial niches in HSCs homing is essential, we aimed to study bone turnover and angiogenesis in 29 patients with lymphoma/multiple myeloma undergoing Hematopoietic Stem Cell Transplantation (HSCT). METHODS: Serum samples were collected before High Dose Chemotherapy (HDT), at the end of HDT, after HSC infusion, at the nadir of myelotoxicity and at engraftment. Bone metabolism (CTX, TRACP-5b, bALP, OC, DKK1, RANKL, OPG) and angiogenesis (Ang1, Ang2) markers were measured...
November 6, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/29093789/bone-mineral-density-and-physical-performance-of-female-patients-27-years-or-longer-after-surgery-for-adolescent-idiopathic-scoliosis
#18
Tsutomu Akazawa, Toshiaki Kotani, Tsuyoshi Sakuma, Takehide Katogi, Shohei Minami, Hisateru Niki, Yoshiaki Torii, Shigeta Morioka, Sumihisa Orita, Kazuhide Inage, Kazuki Fujimoto, Yasuhiro Shiga, Kazuhisa Takahashi, Seiji Ohtori
Study Design: Retrospective cohort study. Purpose: To assess bone mineral density (BMD) and bone metabolism ≥27 years after surgery in female patients who underwent spinal fusion for adolescent idiopathic scoliosis (AIS) during adolescence and to determine their associations with physical performance. Overview of Literature: There are no studies investigating postsurgical BMD in middle-aged AIS patients. Methods: This study included 23 patients who provided informed consent among 229 female patients with AIS who underwent spinal fusion from 1968 until 1988...
October 2017: Asian Spine Journal
https://www.readbyqxmd.com/read/29084147/caffeine-at-a-moderate-dose-did-not-affect-the-skeletal-system-of-rats-with-streptozotocin-induced-diabetes
#19
Joanna Folwarczna, Aleksandra Janas, Urszula Cegieła, Maria Pytlik, Leszek Śliwiński, Magdalena Matejczyk, Anna Nowacka, Karolina Rudy, Zora Krivošíková, Kornélia Štefíková, Martin Gajdoš
Diabetes may lead to the development of osteoporosis. Coffee drinking, apart from its health benefits, is taken into consideration as an osteoporosis risk factor. Data from human and animal studies on coffee and caffeine bone effects are inconsistent. The aim of the study was to investigate effects of caffeine at a moderate dose on the skeletal system of rats in two models of experimental diabetes induced by streptozotocin. Effects of caffeine administered orally (20 mg/kg aily for four weeks) were investigated in three-month-old female Wistar rats, which, two weeks before the start of caffeine administration, received streptozotocin (60 mg/kg, intraperitoneally) alone or streptozotocin after nicotinamide (230 mg/kg, intraperitoneally)...
October 30, 2017: Nutrients
https://www.readbyqxmd.com/read/29080972/the-proteasome-and-myeloma-associated-bone-disease
#20
REVIEW
Fabrizio Accardi, Denise Toscani, Federica Costa, Franco Aversa, Nicola Giuliani
Bone disease is the hallmark of multiple myeloma (MM), a hematological malignancy characterized by osteolytic lesions due to a severe uncoupled and unbalanced bone remodeling with pronounced osteoblast suppression. Bone metastasis is also a frequent complication of solid tumors including advanced breast or prostate cancer. In the past years, the ubiquitin-proteasome pathway has been proved critical in regulating the balance between bone formation and bone resorption. Proteasome inhibitors (PIs) are a new class of drugs, currently used in the treatment of MM, that affect both tumor cells and bone microenvironment...
October 28, 2017: Calcified Tissue International
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