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Bastian Ebeling, Khaled Belal, François Stoffelbach, Patrice Woisel, Muriel Lansalot, Franck D'Agosto
A robust and straightforward synthesis of waterborne polymer nanospheres bearing the supramolecular association unit dialkoxynapthalene at their surface is presented using polymerization-induced self-assembly (PISA). A RAFT agent bearing this unit is first employed to produce poly(acrylic acid) chains, which are then chain-extended with styrene (S) to spontaneously form the nano-objects via RAFT aqueous emulsion polymerization. The particular challenge posed by the dialkoxynapthalene hydrophobicity can be overcome by the use of PISA and the deprotonation of the poly(acrylic acid)...
September 10, 2018: Macromolecular Rapid Communications
A Trinh, P Wong, M C Fahey, P R Ebeling, P J Fuller, F Milat
CONTEXT: Bone fragility in cerebral palsy (CP) is secondary to a complex interplay of functional, hormonal, and nutritional factors that affect bone remodelling. A greater understanding of bone microarchitectural changes seen in CP should assist therapeutic decision making. OBJECTIVE: To examine the relationship between trabecular bone score (TBS), BMD and fractures in adults with CP; the influence of clinical factors and body composition on bone microarchitecture were explored...
September 5, 2018: Bone
D L Kendler, J J Body, M L Brandi, R Broady, J Cannata-Andia, M J Cannata-Ortiz, A El Maghraoui, G Guglielmi, P Hadji, D D Pierroz, T J de Villiers, R Rizzoli, P R Ebeling
Autologous and allogeneic hematopoietic stem cell transplantation (HSCT) is the treatment of choice for patients with some malignant and non-malignant hematological diseases. Advances in transplantation techniques and supportive care measures have substantially increased the number of long-term HSCT survivors. This has led to an increasing patient population suffering from the late effects of HSCT, of which, bone loss and its consequent fragility fractures lead to substantial morbidity. Altered bone health, with consequent fragility fractures, and chronic graft-versus-host disease (GVHD) are factors affecting long-term quality of life after HSCT...
September 3, 2018: Osteoporosis International
Lewan Parker, Xuzhu Lin, Andrew Garnham, Glenn McConell, Nigel K Stepto, David L Hare, Elizabeth Byrnes, Peter R Ebeling, Ego Seeman, Tara C Brennan-Speranza, Itamar Levinger
In mice, glucocorticoid-induced insulin resistance occurs largely through impaired osteoblast function and decreased circulating undercarboxylated osteocalcin (ucOC). Whether these mechanisms contribute to glucocorticoid-induced insulin resistance in humans has yet to be established. In addition, the effects of glucocorticoids on the exercise-induced increase in circulating ucOC and insulin sensitivity are also unknown. We hypothesized that acute glucocorticoid treatment would lead to basal and postexercise insulin resistance in part through decreased circulating ucOC and ucOC-mediated skeletal muscle protein signaling...
August 23, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Peter Ebeling, Robert Adler, Glenville Jones, Uri A Liberman, Gherando Mazziotti, Salvatore Minisola, Craig Munns, Nicola Napoli, Anastassios Pittas, Andrea Giustina, John P Bilezikian, Rene Rizzoli
Objective The central role of vitamin D in bone health is well recognized. However, controversies regarding its clinical application remain. We therefore aimed to review the definition of hypovitaminosis D, the skeletal and extra-skeletal effects of vitamin D, and the available therapeutic modalities. Design Narrative and systematic literature review. Methods An international working group that reviewed the current evidence linking bone and extra-skeletal health and vitamin D therapy to identify knowledge gaps for future research...
August 21, 2018: European Journal of Endocrinology
Qigang Zhong, Daniel Ebeling, Jalmar Tschakert, Yixuan Gao, Deliang Bao, Shixuan Du, Chen Li, Lifeng Chi, André Schirmeisen
Site-selective functionalization of only one of two identical chemical groups within one molecule is highly challenging, which hinders the production of complex organic macromolecules. Here we demonstrate that adsorption of 4,4″-diamino-p-terphenyl on a metal surface leads to a dissymmetric binding affinity. With low temperature atomic force microscopy, using CO-tip functionalization, we reveal the asymmetric adsorption geometries of 4,4″-diamino-p-terphenyl on Cu(111), while on Au(111) the symmetry is retained...
August 16, 2018: Nature Communications
Niek E G Beurskens, Quint A J Hagdorn, Thomas M Gorter, Rolf M F Berger, Karin M Vermeulen, Joost P van Melle, Tjark E Ebels, George K Lui, Scott R Ceresnak, Frandics P Chan, Tineke P Willems
Cardiac tachyarrhythmias are the leading cause of morbidity and mortality in patients with repaired tetralogy of Fallot (TOF). We evaluated risk factors for sustained ventricular tachyarrhythmia (VT) and atrial tachyarrhythmia (ATA) in these patients. Patients (n = 319) who underwent cardiac magnetic resonance (CMR) imaging at two tertiary centers between 2007 and 2016 were assessed. Potential risk markers, based on history, cardiac magnetic resonance imaging (CMR), electrocardiography (ECG) and echocardiography, were analyzed for prediction of the primary endpoint of VT, and the secondary endpoint of ATA...
August 9, 2018: International Journal of Cardiovascular Imaging
Alexander J Rodríguez, Joshua R Lewis, David S Scott, Douglas P Kiel, John T Schousboe, Peter R Ebeling, Richard L Prince
The objective of the study was to determine the association between AAC and neuromuscular function over 5 years. Participants in this study were ambulant women over 70 years old residing in Perth, Western Australia who participated in the Calcium Intake Fracture Outcomes Study, a randomised controlled trial of calcium supplementation. 1046 women (mean age = 74.9 ± 2.6 years; BMI = 27.1 ± 4.4 kg/m2 ) were included. Lateral spine images captured during bone density testing were scored for AAC (AAC24; 0-24) at baseline...
July 23, 2018: Calcified Tissue International
Hanh H Nguyen, Phillip Wong, Boyd J Strauss, Peter R Ebeling, Frances Milat, Amanda Vincent
Context: Turner Syndrome (TS) is associated with short stature, gonadal failure, and fractures. Spinal trabecular bone score (TBS) is a novel bone imaging modality that has not been evaluated in TS. Objective: To evaluate TBS in TS, and its association with BMD, prevalent fracture and its risk factors. Design and setting: Longitudinal study of TS from a single tertiary hospital between 2006-2017. Patients or Other Participants: Fifty-eight TS subjects aged 20-49 years who underwent DXA...
July 17, 2018: Journal of Clinical Endocrinology and Metabolism
Ebele Onuigbo, Joy Iseghohimhen, Kennedy Chah, Moses Gyang, Anthony Attama
Oral fowl typhoid (FT) vaccine is necessary for improved flock vaccinations and economic growth. This study was undertaken to evaluate the immune responses of birds given oral fowl typhoid vaccine coated with chitosan/alginate microparticles and comparing it with the conventional subcutaneous route of administration. Preliminary studies were done to evaluate the particle size, encapsulation efficiency and agglutination. Sixty day-old chicks were divided into three groups of twenty birds each. This comprised a negative control group NEG 451 (non-vaccinated and non-challenged used as control for cytokine quantification), SC 634 (live 9R vaccine by the injection route) and OCV 567 (live 9R vaccine coated with chitosan/alginate microparticles)...
August 9, 2018: Vaccine
Ashish K Sharma, Nigel D Toussaint, Grahame J Elder, Chamith S Rajapakse, Stephen G Holt, Paul Baldock, Patricia L Robertson, Peter R Ebeling, Olivia R Sorci, Rosemary Masterson
Bone disease in kidney transplant recipients (KTRs) is characterized by bone mineral density (BMD) loss but bone microarchitecture changes are poorly defined. In this prospective cohort study, we evaluated bone microarchitecture using non-invasive imaging modalities; high-resolution magnetic resonance imaging (MRI), peripheral quantitative computed tomography (pQCT), dual energy X-ray absorptiometry (DXA), and the trabecular bone score (TBS) following kidney transplantation. Eleven KTRs (48.3 ± 11.2 years) underwent MRI (tibia), pQCT (radius) and DXA at baseline and 12 months post-transplantation...
July 8, 2018: Clinical Transplantation
Jeffrey P Jacobs, Christo I Tchervenkov, Giovanni Stellin, Hiromi Kurosawa, Constantine Mavroudis, Marcelo B Jatene, Zohair Al-Halees, Sertac M Cicek, Nestor F Sandoval, Carl L Backer, Jorge Cervantes, Joseph A Dearani, Tjark Ebels, Frank Edwin, Kirsten Finucane, Jose Fragata, Krishna S Iyer, Robin H Kinsley, James K Kirklin, Christian Kreutzer, Jinfen Liu, Bohdan Maruszewski, James D St Louis, George E Sarris, Richard A Jonas
The World Society for Pediatric and Congenital Heart Surgery (WSPCHS) is the largest professional organization in the world dedicated to pediatric and congenital heart surgery. The purpose of this article is to document the first decade of the history of WSPCHS from its formation in 2006, to summarize the current status of WSPCHS, and to consider the future of WSPCHS. The WSPCHS was incorporated in Canada on April 7, 2011, with a head office in Montreal, Canada. The vision of the WSPCHS is that every child born anywhere in the world with a congenital heart defect should have access to appropriate medical and surgical care...
July 2018: World Journal for Pediatric & Congenital Heart Surgery
Jennifer F Hoy, Robyn Richardson, Peter R Ebeling, Jhon Rojas, Nicholas Pocock, Stephen J Kerr, Esteban Martinez, Andrew Carr
OBJECTIVE: To compare the effects of switching tenofovir disoproxil fumarate (TDF) or treatment with an intravenous bisphosphonate on bone mineral density (BMD) in HIV-positive adults with low bone mass. DESIGN: Two-year, randomized, open-label study at 10 sites in Australia and Spain. PARTICIPANTS: Of 112 adults on TDF-based antiretroviral therapy (ART) screened, 87 with low BMD (T-score < -1.0 at hip or spine by dual-energy X-ray absorptiometry) and undetectable plasma HIV viral load were randomized to either switch TDF to another active antiretroviral drug or to continue TDF-based ART and receive intravenous zoledronic acid (ZOL) 5 mg annually for 2 years...
September 10, 2018: AIDS
Daniel Ebeling, Marina Šekutor, Marvin Stiefermann, Jalmar Tschakert, Jeremy E P Dahl, Robert M K Carlson, André Schirmeisen, Peter R Schreiner
Deciphering absolute configuration of a single molecule by direct visual inspection is the next step in compound identification, with far-reaching implications for medicinal chemistry, pharmacology, and natural product synthesis. We demonstrate the feasibility of this approach utilizing low temperature atomic force microscopy (AFM) with a CO-functionalized tip to determine the absolute configuration and orientation of a single, adsorbed [123]tetramantane molecule, the smallest chiral diamondoid. We differentiate between single enantiomers on Cu(111) by direct visual inspection, and furthermore identify molecular dimers and molecular clusters...
June 20, 2018: Nature Communications
Anna-Maria Kuivalainen, Freja Ebeling, Per Rosenberg
Background and purpose Local infiltration anaesthesia is frequently painful due to low pH of the used anaesthetics, such as lidocaine. Usually pH of the solution is near 4.0, which causes tissue irritation and excitation of the pain mediating nerve endings. Warming and buffering the local anaesthetic solution have been shown to reduce the patient's experience of pain and unpleasantness during infiltration. Buffering reduces the dissociation of the local anaesthetic molecule and may enhance the anaesthetic's entrance into nerve cells...
January 1, 2014: Scandinavian Journal of Pain
Anna-Maria Kuivalainen, Freja Ebeling, Eira Poikonen, Per H Rosenberg
Background and aims Bone marrow aspiration and/or biopsy (BMAB), performed under local anaesthesia in adults, is a common and often painful procedure. Anxiety is known to intensify pain during the procedure. Nitrous oxide (N2O), known for its sedative and analgesic benefit in various short medical procedures and labour pain, could be advantageous also for pain relief during bone marrow examination. N2O acts rapidly and is eliminated in a couple of minutes once the inhalation is stopped, and occasional side effects (e...
April 1, 2015: Scandinavian Journal of Pain
Anne Fünfhaus, Josefine Göbel, Julia Ebeling, Henriette Knispel, Eva Garcia-Gonzalez, Elke Genersch
American Foulbrood is a worldwide distributed, fatal disease of the brood of the Western honey bee (Apis mellifera). The causative agent of this fatal brood disease is the Gram-positive, spore-forming bacterium Paenibacillus larvae, which can be classified into four different genotypes (ERIC I-IV), with ERIC I and II being the ones isolated from contemporary AFB outbreaks. P. larvae is a peritrichously flagellated bacterium and, hence, we hypothesized that P. larvae is capable of coordinated and cooperative multicellular behaviors like swarming motility and biofilm formation...
June 11, 2018: Scientific Reports
N H Ebel, P Rosenthal
No abstract text is available yet for this article.
June 2018: Alimentary Pharmacology & Therapeutics
Eleanor P Thong, Madhuni Herath, David R Weber, Sanjeeva Ranasinha, Peter R Ebeling, Frances Milat, Helena Teede
BACKGROUND: Type 1 diabetes mellitus (T1DM) is associated with skeletal fragility. While previous meta-analyses have demonstrated an increased risk of fracture in individuals with T1DM, little is known about fracture risk in T1DM, in the absence of age-related confounders. AIMS: To determine the risk of fracture in young and middle-aged adults with T1DM aged 18-50 years old. DESIGN: Systematic review and meta-analysis. DATA SOURCES: Ovid MEDLINE, PubMed, EMBASE, EBM reviews and relevant conference abstracts...
September 2018: Clinical Endocrinology
Ashish K Sharma, Nigel D Toussaint, Grahame J Elder, Rosemary Masterson, Stephen G Holt, Patricia L Robertson, Peter R Ebeling, Paul Baldock, Rhiannon C Miller, Chamith S Rajapakse
BACKGROUND: Chronic kidney disease (CKD) adversely affects bone microarchitecture and increases fracture risk. Historically, bone biopsy has been the 'gold standard' for evaluating renal bone disease but is invasive and infrequently performed. High-resolution magnetic resonance imaging (MRI) quantifies bone microarchitecture noninvasively. In patients with CKD, it has not been compared with results derived from bone biopsy or with imaging using dual energy X-ray absorptiometry (DXA). METHODS: Fourteen patients with end-stage kidney disease (ESKD) underwent MRI at the distal tibia, bone mineral density (BMD) by dual energy X-ray absorptiometry (DXA; hip and spine) and transiliac bone biopsies with histomorphometry and microcomputed tomography (micro-CT)...
September 2018: Bone
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