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Ilana Katz Sand, Michelle T Fabian, Russell Telford, Thomas A Kraus, Mirna Chehade, Madhan Masilamani, Thomas Moran, Colleen Farrell, Shelly Ebel, Lawrence J Cook, John Rose, Fred D Lublin
Objective: This pilot study preliminarily examined the efficacy and tolerability of cetirizine as an add-on to standard therapy for neuromyelitis optica (NMO). Methods: Eligible participants met the Wingerchuk 2006 diagnostic criteria or had a single typical episode along with positive NMO immunoglobulin G. After baseline clinical and laboratory assessments, participants began treatment with cetirizine 10 mg orally daily, in addition to their usual disease-modifying therapy for NMO, and continued for 1 year...
March 2018: Neurology® Neuroimmunology & Neuroinflammation
Elina Peltola, Päivi Hannula, Heini Huhtala, Saara Metso, Ulla Kiviniemi, Martine Vornanen, Juhani Sand, Johanna Laukkarinen, Mirja Tiikkainen, Camilla Schalin-Jäntti, Johanna Arola, Jukka Sirén, Antti Piiroinen, Minna Soinio, Pirjo Nuutila, Mirva Söderström, Hanna Hämäläinen, Leena Moilanen, David Laaksonen, Elina Pirinen, Fia Sundelin, Tapani Ebeling, Pasi Salmela, Markus J Mäkinen, Pia Jaatinen
Objective: Insulinomas are rare pancreatic tumours. Population-based data on their incidence, clinical picture, diagnosis, and treatment are almost nonexistent. The aim of this study was to clarify these aspects in a nationwide cohort of insulinoma patients diagnosed during three decades. Design and Methods: Retrospective analysis on all adult patients diagnosed with insulinoma in Finland during 1980-2010. Results: Seventy-nine patients were diagnosed with insulinoma over the research period...
2018: International Journal of Endocrinology
Wilko Reents, Sebastian Barth, Daniel P Griese, Sebastian Winkler, Jörg Babin-Ebell, Sebastian Kerber, Anno Diegeler, Michael Zacher, Karsten Hamm
OBJECTIVES: Transapical transcatheter aortic valve implantation (TAVI) is associated with increased mortality as compared to the transfemoral (TF) access. Possible mechanisms include different patient risk profiles as well as an intrinsic injury caused by the access route itself. METHODS: All consecutive patients scheduled for TAVI between January 2009 and June 2016 at a single centre were evaluated. A comparison of 30-day mortality and morbidity rates for patients undergoing TF or transapical (TA) TAVI was performed according to the criteria of the Valve Academic Research Consortium 2...
November 9, 2018: European Journal of Cardio-thoracic Surgery
Andrea Giustina, Robert A Adler, Neil Binkley, Roger Bouillon, Peter R Ebeling, Marise Lazaretti-Castro, Claudio Marcocci, Rene Rizzoli, Christopher T Sempos, John P Bilezikian
Context: Vitamin D is classically recognized as a regulator of calcium and phosphorus metabolism. Recent advances in the measurement of vitamin D metabolites, diagnosis of vitamin D deficiency, and clinical observations have led to an appreciation that along with its role in skeletal metabolism, vitamin D may well have an important role in non-classical settings. Measurement of the circulating form of vitamin D that best describes total body stores, namely 25-hydroxyvitamin D, can be unreliable despite many sophisticated methodologies that have been proposed and implemented...
October 31, 2018: Journal of Clinical Endocrinology and Metabolism
U Reinhold, H Petering, T Dirschka, A Rozsondai, J Gille, H Kurzen, R Ostendorf, A Ebeling, M Stocker, P Radny
BACKGROUND: It is important to collect data about the risk of transformation of an actinic keratosis (AK) lesion into squamous cell carcinoma (SCC) after a single photodynamic therapy (PDT) with 5-ALA patch for a longer follow-up period under daily routine. QUESTIONS ADDRESSED: The purpose of this non-interventional study (NIS) was to collect data on the frequency of occurrence of SCCs in the treated area during an interval of two years after a single 5-ALA patch-PDT...
October 16, 2018: Experimental Dermatology
Hanh H Nguyen, Denise M van de Laarschot, Annemieke Jmh Verkerk, Frances Milat, M Carola Zillikens, Peter R Ebeling
Atypical femoral fractures (AFFs) are uncommon and have been associated particularly with long-term antiresorptive therapy, including bisphosphonates. Although the pathogenesis of AFFs is unknown, their identification in bisphosphonate-naïve individuals and in monogenetic bone disorders has led to the hypothesis that genetic factors predispose to AFF. Our aim was to review and summarize the evidence for genetic factors in individuals with AFF. We conducted structured literature searches and hand-searching of conference abstracts/reference lists for key words relating to AFF and identified 2566 citations...
January 2018: JBMR Plus
D Alex Quistberg, Leah L Thompson, James Curtin, Frederick P Rivara, Beth E Ebel
OBJECTIVE: Measure the impact of automated photo speed enforcement in school zones on motorist speed and speeding violation rates during school travel. METHODS: Automated enforcement cameras, active during school commuting hours, were installed around four elementary schools in Seattle, Washington, USA in 2012. We examined the effect of automated enforcement on motorist speeds and speed violation rates during the citation period (10 December 2012 to 15 January 2015) compared with the 'warning' period (1 November to 9 December 2012)...
October 2, 2018: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
Bastian Ebeling, Khaled Belal, François Stoffelbach, Patrice Woisel, Muriel Lansalot, Franck D'Agosto
A robust and straightforward synthesis of waterborne polymer nanospheres bearing the supramolecular association unit dialkoxynapthalene at their surface is presented using polymerization-induced self-assembly (PISA). A RAFT agent bearing this unit is first employed to produce poly(acrylic acid) chains, which are then chain-extended with styrene (S) to spontaneously form the nano-objects via RAFT aqueous emulsion polymerization. The particular challenge posed by the dialkoxynapthalene hydrophobicity can be overcome by the use of PISA and the deprotonation of the poly(acrylic acid)...
September 10, 2018: Macromolecular Rapid Communications
A Trinh, P Wong, M C Fahey, P R Ebeling, P J Fuller, F Milat
CONTEXT: Bone fragility in cerebral palsy (CP) is secondary to a complex interplay of functional, hormonal, and nutritional factors that affect bone remodelling. A greater understanding of bone microarchitectural changes seen in CP should assist therapeutic decision making. OBJECTIVE: To examine the relationship between trabecular bone score (TBS), BMD and fractures in adults with CP; the influence of clinical factors and body composition on bone microarchitecture were explored...
December 2018: Bone
D L Kendler, J J Body, M L Brandi, R Broady, J Cannata-Andia, M J Cannata-Ortiz, A El Maghraoui, G Guglielmi, P Hadji, D D Pierroz, T J de Villiers, R Rizzoli, P R Ebeling
Autologous and allogeneic hematopoietic stem cell transplantation (HSCT) is the treatment of choice for patients with some malignant and non-malignant hematological diseases. Advances in transplantation techniques and supportive care measures have substantially increased the number of long-term HSCT survivors. This has led to an increasing patient population suffering from the late effects of HSCT, of which, bone loss and its consequent fragility fractures lead to substantial morbidity. Altered bone health, with consequent fragility fractures, and chronic graft-versus-host disease (GVHD) are factors affecting long-term quality of life after HSCT...
September 3, 2018: Osteoporosis International
Lewan Parker, Xuzhu Lin, Andrew Garnham, Glenn McConell, Nigel K Stepto, David L Hare, Elizabeth Byrnes, Peter R Ebeling, Ego Seeman, Tara C Brennan-Speranza, Itamar Levinger
In mice, glucocorticoid-induced insulin resistance occurs largely through impaired osteoblast function and decreased circulating undercarboxylated osteocalcin (ucOC). Whether these mechanisms contribute to glucocorticoid-induced insulin resistance in humans has yet to be established. In addition, the effects of glucocorticoids on the exercise-induced increase in circulating ucOC and insulin sensitivity are also unknown. We hypothesized that acute glucocorticoid treatment would lead to basal and postexercise insulin resistance in part through decreased circulating ucOC and ucOC-mediated skeletal muscle protein signaling...
August 23, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Peter Ebeling, Robert Adler, Glenville Jones, Uri A Liberman, Gherando Mazziotti, Salvatore Minisola, Craig Munns, Nicola Napoli, Anastassios Pittas, Andrea Giustina, John P Bilezikian, Rene Rizzoli
Objective: The central role of vitamin D in bone health is well recognized. However, controversies regarding its clinical application remain. We therefore aimed to review the definition of hypovitaminosis D, the skeletal and extra-skeletal effects of vitamin D and the available therapeutic modalities. Design: Narrative and systematic literature review. Methods: An international working group that reviewed the current evidence linking bone and extra-skeletal health and vitamin D therapy to identify knowledge gaps for future research...
October 12, 2018: European Journal of Endocrinology
Qigang Zhong, Daniel Ebeling, Jalmar Tschakert, Yixuan Gao, Deliang Bao, Shixuan Du, Chen Li, Lifeng Chi, André Schirmeisen
Site-selective functionalization of only one of two identical chemical groups within one molecule is highly challenging, which hinders the production of complex organic macromolecules. Here we demonstrate that adsorption of 4,4″-diamino-p-terphenyl on a metal surface leads to a dissymmetric binding affinity. With low temperature atomic force microscopy, using CO-tip functionalization, we reveal the asymmetric adsorption geometries of 4,4″-diamino-p-terphenyl on Cu(111), while on Au(111) the symmetry is retained...
August 16, 2018: Nature Communications
Niek E G Beurskens, Quint A J Hagdorn, Thomas M Gorter, Rolf M F Berger, Karin M Vermeulen, Joost P van Melle, Tjark E Ebels, George K Lui, Scott R Ceresnak, Frandics P Chan, Tineke P Willems
Cardiac tachyarrhythmias are the leading cause of morbidity and mortality in patients with repaired tetralogy of Fallot (TOF). We evaluated risk factors for sustained ventricular tachyarrhythmia (VT) and atrial tachyarrhythmia (ATA) in these patients. Patients (n = 319) who underwent cardiac magnetic resonance (CMR) imaging at two tertiary centers between 2007 and 2016 were assessed. Potential risk markers, based on history, cardiac magnetic resonance imaging (CMR), electrocardiography (ECG) and echocardiography, were analyzed for prediction of the primary endpoint of VT, and the secondary endpoint of ATA...
August 9, 2018: International Journal of Cardiovascular Imaging
Alexander J Rodríguez, Joshua R Lewis, David S Scott, Douglas P Kiel, John T Schousboe, Peter R Ebeling, Richard L Prince
The objective of the study was to determine the association between AAC and neuromuscular function over 5 years. Participants in this study were ambulant women over 70 years old residing in Perth, Western Australia who participated in the Calcium Intake Fracture Outcomes Study, a randomised controlled trial of calcium supplementation. 1046 women (mean age = 74.9 ± 2.6 years; BMI = 27.1 ± 4.4 kg/m2 ) were included. Lateral spine images captured during bone density testing were scored for AAC (AAC24; 0-24) at baseline...
December 2018: Calcified Tissue International
Hanh H Nguyen, Phillip Wong, Boyd J Strauss, Peter R Ebeling, Frances Milat, Amanda Vincent
Context: Turner Syndrome (TS) is associated with short stature, gonadal failure, and fractures. Spinal trabecular bone score (TBS) is a novel bone imaging modality that has not been evaluated in TS. Objective: To evaluate TBS in TS, and its association with BMD, prevalent fracture and its risk factors. Design and setting: Longitudinal study of TS from a single tertiary hospital between 2006-2017. Patients or Other Participants: Fifty-eight TS subjects aged 20-49 years who underwent DXA...
July 17, 2018: Journal of Clinical Endocrinology and Metabolism
Ebele Onuigbo, Joy Iseghohimhen, Kennedy Chah, Moses Gyang, Anthony Attama
Oral fowl typhoid (FT) vaccine is necessary for improved flock vaccinations and economic growth. This study was undertaken to evaluate the immune responses of birds given oral fowl typhoid vaccine coated with chitosan/alginate microparticles and comparing it with the conventional subcutaneous route of administration. Preliminary studies were done to evaluate the particle size, encapsulation efficiency and agglutination. Sixty day-old chicks were divided into three groups of twenty birds each. This comprised a negative control group NEG 451 (non-vaccinated and non-challenged used as control for cytokine quantification), SC 634 (live 9R vaccine by the injection route) and OCV 567 (live 9R vaccine coated with chitosan/alginate microparticles)...
August 9, 2018: Vaccine
Ashish K Sharma, Nigel D Toussaint, Grahame J Elder, Chamith S Rajapakse, Stephen G Holt, Paul Baldock, Patricia L Robertson, Peter R Ebeling, Olivia R Sorci, Rosemary Masterson
Bone disease in kidney transplant recipients (KTRs) is characterized by bone mineral density (BMD) loss but bone microarchitecture changes are poorly defined. In this prospective cohort study, we evaluated bone microarchitecture using non-invasive imaging modalities; high-resolution magnetic resonance imaging (MRI), peripheral quantitative computed tomography (pQCT), dual energy X-ray absorptiometry (DXA), and the trabecular bone score (TBS) following kidney transplantation. Eleven KTRs (48.3 ± 11.2 years) underwent MRI (tibia), pQCT (radius) and DXA at baseline and 12 months post-transplantation...
July 8, 2018: Clinical Transplantation
Jeffrey P Jacobs, Christo I Tchervenkov, Giovanni Stellin, Hiromi Kurosawa, Constantine Mavroudis, Marcelo B Jatene, Zohair Al-Halees, Sertac M Cicek, Nestor F Sandoval, Carl L Backer, Jorge Cervantes, Joseph A Dearani, Tjark Ebels, Frank Edwin, Kirsten Finucane, Jose Fragata, Krishna S Iyer, Robin H Kinsley, James K Kirklin, Christian Kreutzer, Jinfen Liu, Bohdan Maruszewski, James D St Louis, George E Sarris, Richard A Jonas
The World Society for Pediatric and Congenital Heart Surgery (WSPCHS) is the largest professional organization in the world dedicated to pediatric and congenital heart surgery. The purpose of this article is to document the first decade of the history of WSPCHS from its formation in 2006, to summarize the current status of WSPCHS, and to consider the future of WSPCHS. The WSPCHS was incorporated in Canada on April 7, 2011, with a head office in Montreal, Canada. The vision of the WSPCHS is that every child born anywhere in the world with a congenital heart defect should have access to appropriate medical and surgical care...
July 2018: World Journal for Pediatric & Congenital Heart Surgery
Jennifer F Hoy, Robyn Richardson, Peter R Ebeling, Jhon Rojas, Nicholas Pocock, Stephen J Kerr, Esteban Martinez, Andrew Carr
OBJECTIVE: To compare the effects of switching tenofovir disoproxil fumarate (TDF) or treatment with an intravenous bisphosphonate on bone mineral density (BMD) in HIV-positive adults with low bone mass. DESIGN: Two-year, randomized, open-label study at 10 sites in Australia and Spain. PARTICIPANTS: Of 112 adults on TDF-based antiretroviral therapy (ART) screened, 87 with low BMD (T-score < -1.0 at hip or spine by dual-energy X-ray absorptiometry) and undetectable plasma HIV viral load were randomized to either switch TDF to another active antiretroviral drug or to continue TDF-based ART and receive intravenous zoledronic acid (ZOL) 5 mg annually for 2 years...
September 10, 2018: AIDS
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