keyword
https://read.qxmd.com/read/38619737/antibiotics-not-associated-with-shorter-duration-or-reduced-severity-of-acute-lower-respiratory-tract-infection
#1
JOURNAL ARTICLE
Daniel J Merenstein, Bruce Barrett, Mark H Ebell
BACKGROUND: Antibiotic use remains common for the treatment of lower respiratory tract infections. The objective of this study was to evaluate the impact of antibiotic use on the duration and severity of acute lower respiratory tract infection (LRTI). PARTICIPANTS: Adult patients presenting to US primary or urgent care sites with a chief complaint of cough and symptoms consistent with LRTI. MAIN MEASURES: Collected data included demographics, comorbidities, symptoms, and 48 viral and bacterial respiratory pathogens by PCR...
April 15, 2024: Journal of General Internal Medicine
https://read.qxmd.com/read/38584736/the-unanti-cipated-oxidation-of-a-tertiary-amine-in-a-tetra-cyclic-glyoxal-cyclam-condensate-yielding-zinc-ii-coordinated-to-a-sterically-hindered-amine-oxide
#2
JOURNAL ARTICLE
Daniel J Hubin, Blue M Cunningham, Timothy J Hubin, Jonathan P Ebel, Jeanette A Krause, Allen G Oliver
The complex, tri-chlorido-(1,4,11-tri-aza-8-azonia-tetra-cyclo-[6.6.2.04,16 .011,15 ]hexa-decane 1-oxide-κ O )zinc(II) monohydrate, [ZnCl3 (C12 H23 N4 O)]·H2 O, ( I ), has monoclinic symmetry (space group P 21 / n ) at 120 K. The zinc(II) center adopts a slightly distorted tetra-hedral coordination geometry and is coordinated by three chlorine atoms and the oxygen atom of the oxidized tertiary amine of the tetra-cycle. The amine nitro-gen atom, inside the ligand cleft, is protonated and forms a hydrogen bond to the oxygen of the amine oxide...
March 1, 2024: Acta Crystallographica. Section E, Crystallographic Communications
https://read.qxmd.com/read/38533939/impact-of-prosthesis-patient-mismatch-after-surgical-aortic-valve-replacement-systematic-review-and-meta-analysis-of-reconstructed-time-to-event-data-of-122%C3%A2-989-patients-with-592%C3%A2-952-patient-years
#3
JOURNAL ARTICLE
Michel Pompeu Sá, Xander Jacquemyn, Jef Van den Eynde, Danny Chu, Derek Serna-Gallegos, Tjark Ebels, Marie-Annick Clavel, Philippe Pibarot, Ibrahim Sultan
BACKGROUND: It remains controversial whether prosthesis-patient mismatch (PPM) impacts long-term outcomes after surgical aortic valve replacement. We aimed to evaluate the association of PPM with mortality, rehospitalizations, and aortic valve reinterventions. METHODS AND RESULTS: We performed a systematic review with meta-analysis of reconstructed time-to-event data of studies published by March 2023 (according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses)...
March 27, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38529428/novel-use-of-clonidine-patch-to-treat-tizanidine-withdrawal
#4
Aaron B Deutsch, Clare F Hartman, Curtis P Flaherty, Natalie E Ebeling-Koning, Gillian A Beauchamp, Kenneth D Katz
Tizanidine is commonly prescribed for muscle spasticity and pain. Yet, withdrawal is rarely reported. Tizanidine stimulates presynaptic α-2 adrenergic and imidazoline receptors decreasing norepinephrine release. Abrupt cessation can cause withdrawal. Current treatment strategies include tapering oral tizanidine or substituting oral clonidine. A 52-year-old male with a history of hypertension, diabetes, coronary artery disease, and chronic back pain presented with altered mental status, agitation, hypertensive emergency (blood pressure: 250/145 mmHg), and tachycardia...
February 2024: Curēus
https://read.qxmd.com/read/38502455/correction-vitamin-d-status-and-supplementation-before-and-after-bariatric-surgery-recommendations-based-on-a-systematic-review-and-meta%C3%A2-analysis
#5
Andrea Giustina, Luigi di Filippo, Antonio Facciorusso, Robert A Adler, Neil Binkley, Jens Bollerslev, Roger Bouillon, Felipe F Casanueva, Giulia Martina Cavestro, Marlene Chakhtoura, Caterina Conte, Lorenzo M Donini, Peter R Ebeling, Angelo Fassio, Stefano Frara, Claudia Gagnon, Giovanni Latella, Claudio Marcocci, Jeffrey I Mechanick, Salvatore Minisola, René Rizzoli, Ferruccio Santini, Joseph L Shaker, Christopher Sempos, Fabio Massimo Ulivieri, Jyrki K Virtanen, Nicola Napoli, Anne L Schafer, John P Bilezikian
No abstract text is available yet for this article.
April 2024: Reviews in Endocrine & Metabolic Disorders
https://read.qxmd.com/read/38479897/the-effect-of-three-years-of-vitamin-d-supplementation-on-erectile-dysfunction-results-from-the-randomized-placebo-controlled-d-health-trial
#6
RANDOMIZED CONTROLLED TRIAL
Briony Duarte Romero, Mary Waterhouse, Catherine Baxter, Donald S A McLeod, Dallas R English, Bruce K Armstrong, Eric Chung, Peter R Ebeling, Gunter Hartel, Jolieke C van der Pols, Matthew Roberts, Alison J Venn, Penelope M Webb, David C Whiteman, Rachel E Neale
BACKGROUND & AIMS: Erectile dysfunction is common among older men and has been associated with low serum 25-hydroxy vitamin D concentration. However, this association may be due to uncontrolled confounding, and there is a paucity of evidence from interventional studies. We aimed to examine the effect of vitamin D supplementation on the prevalence of erectile dysfunction, in an exploratory analysis using data from a large randomized controlled trial. METHODS: The D-Health Trial recruited Australians aged 60-84 years between January 2014 and May 2015 and randomly assigned them to supplementation with 60,000 IU of vitamin D or placebo per month for up to 5 years...
April 2024: Clinical Nutrition ESPEN
https://read.qxmd.com/read/38453933/effects-of-plant-diversity-on-productivity-strengthen-over-time-due-to-trait-dependent-shifts-in-species-overyielding
#7
JOURNAL ARTICLE
Liting Zheng, Kathryn E Barry, Nathaly R Guerrero-Ramírez, Dylan Craven, Peter B Reich, Kris Verheyen, Michael Scherer-Lorenzen, Nico Eisenhauer, Nadia Barsoum, Jürgen Bauhus, Helge Bruelheide, Jeannine Cavender-Bares, Jiri Dolezal, Harald Auge, Marina V Fagundes, Olga Ferlian, Sebastian Fiedler, David I Forrester, Gislene Ganade, Tobias Gebauer, Josephine Haase, Peter Hajek, Andy Hector, Bruno Hérault, Dirk Hölscher, Kristin B Hulvey, Bambang Irawan, Hervé Jactel, Julia Koricheva, Holger Kreft, Vojtech Lanta, Jan Leps, Simone Mereu, Christian Messier, Florencia Montagnini, Martin Mörsdorf, Sandra Müller, Bart Muys, Charles A Nock, Alain Paquette, William C Parker, John D Parker, John A Parrotta, Gustavo B Paterno, Michael P Perring, Daniel Piotto, H Wayne Polley, Quentin Ponette, Catherine Potvin, Julius Quosh, Boris Rewald, Douglas L Godbold, Jasper van Ruijven, Rachel J Standish, Artur Stefanski, Leti Sundawati, Jon Urgoiti, Laura J Williams, Brian J Wilsey, Baiyu Yang, Li Zhang, Zhao Zhao, Yongchuan Yang, Hans Sandén, Anne Ebeling, Bernhard Schmid, Markus Fischer, Martyna M Kotowska, Cecilia Palmborg, David Tilman, Enrong Yan, Yann Hautier
Plant diversity effects on community productivity often increase over time. Whether the strengthening of diversity effects is caused by temporal shifts in species-level overyielding (i.e., higher species-level productivity in diverse communities compared with monocultures) remains unclear. Here, using data from 65 grassland and forest biodiversity experiments, we show that the temporal strength of diversity effects at the community scale is underpinned by temporal changes in the species that yield. These temporal trends of species-level overyielding are shaped by plant ecological strategies, which can be quantitatively delimited by functional traits...
March 7, 2024: Nature Communications
https://read.qxmd.com/read/38443188/egfr-and-her-2-oncogenes-expression-in-an-experimental-model-of-two-stage-chemically-induced-carcinogenesis-in-mouse-skin
#8
JOURNAL ARTICLE
Stavroula Diamantopoulou, Christos Yapijakis, Veronica Papakosta, Marcel Ebeling, Andreas C Lazaris, Spyridoula Derka, Antonis Vylliotis, Pantelis Diamantopoulos, Georgia Vairaktari, Stavros Vassiliou
The aim of the study was to investigate the expression of EGFR and HER-2 oncogenes using an experimental two stage chemically induced carcinogenesis protocol on the dorsal skin in FVB/N mice. Forty female FVB/N mice 4 weeks old, were grouped into one control (n = 8) and two experimental groups (Group A: n = 16, Group B: n = 16) following a randomization process. Two-stage carcinogenesis protocol, was implicated, including an initial treatment with 97.4 nmol DMBA on their shaved dorsal skin and subsequent treatments of 32...
January 5, 2024: Journal of Cranio-maxillo-facial Surgery
https://read.qxmd.com/read/38396142/bone-health-in-women-with-premature-ovarian-insufficiency-early-menopause-a-23-year-longitudinal-analysis
#9
JOURNAL ARTICLE
A R Jones, J Enticott, P R Ebeling, G D Mishra, H T Teede, A J Vincent
STUDY QUESTION: What is the frequency of, and predictors for, osteoporosis, fractures, and osteoporosis management (investigation, treatment) in women with premature ovarian insufficiency (POI; menopause <40 years) and early menopause (EM; menopause 40-44years)? SUMMARY ANSWER: Over the 23-year follow-up duration, at a mean age of 68 years, women with POI/EM had higher osteoporosis/fracture risk and prevalence, higher osteoporosis screening and anti-osteoporosis medication use compared to women with usual age menopause; increasing age was predictive of increased risk of osteoporosis/fracture and menopause hormone therapy (MHT) prior to or at study entry (aged 45-50 years) was protective...
February 23, 2024: Human Reproduction
https://read.qxmd.com/read/38360961/identifying-the-best-initial-oral-antibiotics-for-adults-with-community-acquired-pneumonia-a-network-meta-analysis
#10
Peter K Kurotschka, Michelle Bentivegna, Cassie Hulme, Mark H Ebell
BACKGROUND: The objective of this network meta-analysis was to compare rates of clinical response and mortality for empiric oral antibiotic regimens in adults with mild-moderate community-acquired pneumonia (CAP). METHODS: We searched PubMed, Cochrane, and the reference lists of systematic reviews and clinical guidelines. We included randomized trials of adults with radiologically confirmed mild to moderate CAP initially treated orally and reporting clinical cure or mortality...
February 15, 2024: Journal of General Internal Medicine
https://read.qxmd.com/read/38321800/impact-of-binet-staging-versus-tumour-bulk-on-treatment-outcome-in-chronic-lymphocytic-leukaemia
#11
JOURNAL ARTICLE
Anazoeze Jude Madu, Helen Chioma Okoye, Ebele Adaobi Muoghalu, Angela Ogechukwu Ugwu, Augustine Nwakuche Duru, Charles Emeka Nonyelu, Ikechukwu Okwudili Anigbogu, Chinedu Anthony Ezekekwu
BACKGROUND: Most of the predictive tools put up to prognosticate treatment outcomes in patients with chronic lymphocytic leukaemia (CLL) are not easily available and affordable in our resource-constrained environment. AIM: The aim of this study was to evaluate the impact of staging and some tumour bulk on treatment outcomes of persons with CLL, Enugu, Nigeria. PATIENTS AND METHODS: This is a 10-year review of the CLL data from the haemato-oncology unit of a Nigerian tertiary hospital to evaluate the impact of staging and tumour bulk indicators...
January 1, 2024: Nigerian Postgraduate Medical Journal
https://read.qxmd.com/read/38319485/the-galad-score-and-the-balad-2-score-correlate-with-transarterial-and-systemic-treatment-response-and-survival-in-patients-with-hepatocellular-carcinoma
#12
JOURNAL ARTICLE
Anne Olbrich, Johannes Niemeyer, Hendrik Seiffert, Sebastian Ebel, Olga Gros, Florian Lordick, Dirk Forstmeyer, Daniel Seehofer, Sebastian Rademacher, Timm Denecke, Madlen Matz-Soja, Thomas Berg, Florian van Bömmel
PURPOSE: The GALAD score and the BALAD-2 score are biomarker-based scoring systems used to detect hepatocellular carcinoma (HCC). Both incorporate levels of alpha-fetoprotein (AFP), lens culinaris agglutinin-reactive AFP (AFP-L3), and des-gamma-carboxy prothrombin (DCP). Our objective was to examine the relationship between the GALAD score as well as the BALAD-2 score and treatment response to transarterial or systemic treatments in patients with HCC. METHODS: A total of 220 patients with HCC treated with either transarterial (n = 121) or systemic treatments (n = 99; mainly Sorafenib) were retrospectively analyzed...
February 6, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38317335/anti-spike-antibody-durability-after-sars-cov-2-vaccination-in-adolescent-solid-organ-transplant-recipients
#13
MULTICENTER STUDY
John McAteer, Divya D Kalluri, Rivka R Abedon, Caroline X Qin, Scott R Auerbach, Olga Charnaya, Lara A Danziger-Isakov, Noelle H Ebel, Amy G Feldman, Evelyn K Hsu, Saeed Mohammad, Emily R Perito, Ashley M Thomas, Teresa P Y Chiang, Jacqueline M Garonzik-Wang, Dorry L Segev, William A Werbel, Douglas B Mogul
BACKGROUND: Adolescent solid organ transplant recipients (aSOTRs) who received three doses of the COVID-19 mRNA vaccine experience high seroconversion rates and antibody persistence for up to 3 months. Long-term antibody durability beyond this timeframe following three doses of the SARS-CoV-2 mRNA vaccine remains unknown. We describe antibody responses 6 months following the third vaccine dose (D3) of the BNT162b2 mRNA vaccination among aSOTRs. METHODS: Participants in a multi-center, observational cohort who received the third dose of the vaccine were analyzed for antibodies to the SARS-CoV-2 spike protein receptor-binding domain (Roche Elecsys anti-SARS-CoV-2-S positive: ≥0...
February 2024: Pediatric Transplantation
https://read.qxmd.com/read/38233483/inpp5a-phosphatase-is-a-synthetic-lethal-target-in-gnaq-and-gna11-mutant-melanomas
#14
JOURNAL ARTICLE
Ahmed M O Elbatsh, Ali Amin-Mansour, Anne Haberkorn, Claudia Textor, Nicolas Ebel, Emilie Renard, Lisa M Koch, Femke C Groenveld, Michelle Piquet, Ulrike Naumann, David A Ruddy, Vincent Romanet, Julia M Martínez Gómez, Matthew D Shirley, Peter Wipfli, Christian Schnell, Markus Wartmann, Martin Rausch, Martine J Jager, Mitchell P Levesque, Sauveur-Michel Maira, Eusebio Manchado
Activating mutations in GNAQ/GNA11 occur in over 90% of uveal melanomas (UMs), the most lethal melanoma subtype; however, targeting these oncogenes has proven challenging and inhibiting their downstream effectors show limited clinical efficacy. Here, we performed genome-scale CRISPR screens along with computational analyses of cancer dependency and gene expression datasets to identify the inositol-metabolizing phosphatase INPP5A as a selective dependency in GNAQ/11-mutant UM cells in vitro and in vivo. Mutant cells intrinsically produce high levels of the second messenger inositol 1,4,5 trisphosphate (IP3) that accumulate upon suppression of INPP5A, resulting in hyperactivation of IP3-receptor signaling, increased cytosolic calcium and p53-dependent apoptosis...
January 17, 2024: Nature Cancer
https://read.qxmd.com/read/38190514/extreme-drought-impacts-have-been-underestimated-in-grasslands-and-shrublands-globally
#15
JOURNAL ARTICLE
Melinda D Smith, Kate D Wilkins, Martin C Holdrege, Peter Wilfahrt, Scott L Collins, Alan K Knapp, Osvaldo E Sala, Jeffrey S Dukes, Richard P Phillips, Laura Yahdjian, Laureano A Gherardi, Timothy Ohlert, Claus Beier, Lauchlan H Fraser, Anke Jentsch, Michael E Loik, Fernando T Maestre, Sally A Power, Qiang Yu, Andrew J Felton, Seth M Munson, Yiqi Luo, Hamed Abdoli, Mehdi Abedi, Concepción L Alados, Juan Alberti, Moshe Alon, Hui An, Brian Anacker, Maggie Anderson, Harald Auge, Seton Bachle, Khadijeh Bahalkeh, Michael Bahn, Amgaa Batbaatar, Taryn Bauerle, Karen H Beard, Kai Behn, Ilka Beil, Lucio Biancari, Irmgard Blindow, Viviana Florencia Bondaruk, Elizabeth T Borer, Edward W Bork, Carlos Martin Bruschetti, Kerry M Byrne, James F Cahill, Dianela A Calvo, Michele Carbognani, Augusto Cardoni, Cameron N Carlyle, Miguel Castillo-Garcia, Scott X Chang, Jeff Chieppa, Marcus V Cianciaruso, Ofer Cohen, Amanda L Cordeiro, Daniela F Cusack, Sven Dahlke, Pedro Daleo, Carla M D'Antonio, Lee H Dietterich, Tim S Doherty, Maren Dubbert, Anne Ebeling, Nico Eisenhauer, Felícia M Fischer, T'ai G W Forte, Tobias Gebauer, Beatriz Gozalo, Aaron C Greenville, Karlo G Guidoni-Martins, Heather J Hannusch, Siri Vatsø Haugum, Yann Hautier, Mariet Hefting, Hugh A L Henry, Daniela Hoss, Johannes Ingrisch, Oscar Iribarne, Forest Isbell, Yari Johnson, Samuel Jordan, Eugene F Kelly, Kaitlin Kimmel, Juergen Kreyling, György Kröel-Dulay, Alicia Kröpfl, Angelika Kübert, Andrew Kulmatiski, Eric G Lamb, Klaus Steenberg Larsen, Julie Larson, Jason Lawson, Cintia V Leder, Anja Linstädter, Jielin Liu, Shirong Liu, Alexandra G Lodge, Grisel Longo, Alejandro Loydi, Junwei Luan, Frederick Curtis Lubbe, Craig Macfarlane, Kathleen Mackie-Haas, Andrey V Malyshev, Adrián Maturano-Ruiz, Thomas Merchant, Daniel B Metcalfe, Akira S Mori, Edwin Mudongo, Gregory S Newman, Uffe N Nielsen, Dale Nimmo, Yujie Niu, Paola Nobre, Rory C O'Connor, Romà Ogaya, Gastón R Oñatibia, Ildikó Orbán, Brooke Osborne, Rafael Otfinowski, Meelis Pärtel, Josep Penuelas, Pablo L Peri, Guadalupe Peter, Alessandro Petraglia, Catherine Picon-Cochard, Valério D Pillar, Juan Manuel Piñeiro-Guerra, Laura W Ploughe, Robert M Plowes, Cristy Portales-Reyes, Suzanne M Prober, Yolanda Pueyo, Sasha C Reed, Euan G Ritchie, Dana Aylén Rodríguez, William E Rogers, Christiane Roscher, Ana M Sánchez, Bráulio A Santos, María Cecilia Scarfó, Eric W Seabloom, Baoku Shi, Lara Souza, Andreas Stampfli, Rachel J Standish, Marcelo Sternberg, Wei Sun, Marie Sünnemann, Michelle Tedder, Pål Thorvaldsen, Dashuan Tian, Katja Tielbörger, Alejandro Valdecantos, Liesbeth van den Brink, Vigdis Vandvik, Mathew R Vankoughnett, Liv Guri Velle, Changhui Wang, Yi Wang, Glenda M Wardle, Christiane Werner, Cunzheng Wei, Georg Wiehl, Jennifer L Williams, Amelia A Wolf, Michaela Zeiter, Fawei Zhang, Juntao Zhu, Ning Zong, Xiaoan Zuo
Climate change is increasing the frequency and severity of short-term (~1 y) drought events-the most common duration of drought-globally. Yet the impact of this intensification of drought on ecosystem functioning remains poorly resolved. This is due in part to the widely disparate approaches ecologists have employed to study drought, variation in the severity and duration of drought studied, and differences among ecosystems in vegetation, edaphic and climatic attributes that can mediate drought impacts. To overcome these problems and better identify the factors that modulate drought responses, we used a coordinated distributed experiment to quantify the impact of short-term drought on grassland and shrubland ecosystems...
January 23, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38166123/caregivers-and-providers-perspectives-of-social-and-medical-care-after-pediatric-liver-transplant-results-from-the-multicenter-social-tx-study
#16
JOURNAL ARTICLE
Sharad I Wadhwani, Alejandra Alvarado, Holly P Shifman, Bethany Bautista, Jared Yalung, James E Squires, Kathleen Campbell, Noelle H Ebel, Evelyn Hsu, Jennifer Vittorio, Shannon Zielsdorf, Dev M Desai, John C Bucuvalas, Laura Gottlieb, Uma Kotagal, Courtney R Lyles, Sara L Ackerman, Jennifer C Lai
Disparities exist in pediatric liver transplant (LT). We characterized barriers and facilitators to providing transplant and social care within pediatric LT clinics. This was a multicenter qualitative study. We oversampled caregivers reporting household financial strain, material economic hardship, or demonstrating poor health literacy. We also enrolled transplant team members. We conducted semistructured interviews with participants. Caregiver interviews focused on challenges addressing transplant and household needs...
December 29, 2023: Liver Transplantation
https://read.qxmd.com/read/38159991/ibuprofen-reduces-5-year-overall-survival-of-head-and-neck-cancer-patients-with-immunotherapy-a-retrospective-case-controlled-real-world-data-analysis-of-10-000-patients
#17
JOURNAL ARTICLE
Marcel Ebeling, Spyridoula Derka, Josefine Baudrexl, Andreas Sakkas, Mario Scheurer, Frank Wilde, Alexander Schramm, Sebastian Pietzka
BACKGROUND/AIM: Resistance to immunotherapy can be explained by an abnormal microbiome of the gut. In Europe in particular, the use of ibuprofen, with or without proton-pump inhibitors to protect the gastric mucosa, is widespread. This study aimed to investigate the impact of ibuprofen use on the effectiveness of immunotherapy in patients with head and neck carcinoma. PATIENTS AND METHODS: Data from patients with head and neck carcinoma (ICD-10-Codes: C00-C14) receiving pembrolizumab, from the TriNetX network, were analyzed...
January 2024: Anticancer Research
https://read.qxmd.com/read/38146932/event-free-survival-of-maralixibat-treated-patients-with-alagille-syndrome-compared-to-a-real-world-cohort-from-gala
#18
JOURNAL ARTICLE
Bettina E Hansen, Shannon M Vandriel, Pamela Vig, Will Garner, Douglas B Mogul, Kathleen M Loomes, David A Piccoli, Elizabeth B Rand, Irena Jankowska, Piotr Czubkowski, Dorota Gliwicz-Miedzińska, Emmanuel M Gonzales, Emmanuel Jacquemin, Jérôme Bouligand, Lorenzo D'Antiga, Emanuele Nicastro, Henrik Arnell, Björn Fischler, Étienne Sokal, Tanguy Demaret, Susan Siew, Michael Stormon, Saul J Karpen, Rene Romero, Noelle H Ebel, Jeffrey A Feinstein, Amin J Roberts, Helen M Evans, Shikha S Sundaram, Alexander Chaidez, Winita Hardikar, Sahana Shankar, Ryan T Fischer, Florence Lacaille, Dominique Debray, Henry C Lin, M Kyle Jensen, Catalina Jaramillo, Palaniswamy Karthikeyan, Giuseppe Indolfi, Henkjan J Verkade, Catherine Larson-Nath, Ruben E Quiros-Tejeira, Pamela L Valentino, Maria Rogalidou, Antal Dezsőfi, James E Squires, Kathleen Schwarz, Pier Luigi Calvo, Jesus Quintero Bernabeu, Andréanne N Zizzo, Gabriella Nebbia, Pinar Bulut, Ermelinda Santos-Silva, Rima Fawaz, Silvia Nastasio, Wikrom Karnsakul, María Legarda Tamara, Cristina Molera Busoms, Deirdre Kelly, Thomas Damgaard Sandahl, Carolina Jimenez-Rivera, Jesus M Banales, Quais Mujawar, Li-Ting Li, Huiyu She, Jian-She Wang, Kyung Mo Kim, Seak Hee Oh, Maria Camila Sanchez, Maria Lorena Cavalieri, Way Seah Lee, Christina Hajinicolaou, Chatmanee Lertudomphonwanit, Orith Waisbourd-Zinman, Cigdem Arikan, Seema Alam, Elisa Carvalho, Melina Melere, John Eshun, Zerrin Önal, Dev M Desai, Sabina Wiecek, Raquel Borges Pinto, Victorien M Wolters, Jennifer Garcia, Marisa Beretta, Nanda Kerkar, Jernej Brecelj, Nathalie Rock, Eberhard Lurz, Niviann Blondet, Uzma Shah, Richard J Thompson, Binita M Kamath
BACKGROUND AND AIMS: Alagille syndrome (ALGS) is characterized by chronic cholestasis with associated pruritus and extrahepatic anomalies. Maralixibat, an ileal bile acid transporter inhibitor, is the first-approved pharmacologic therapy for cholestatic pruritus in ALGS. Since long-term placebo-controlled studies are not feasible or ethical in children with rare diseases, a novel approach was taken comparing 6-year outcomes from maralixibat trials with an aligned and harmonized natural history cohort from the Global ALagille Alliance (GALA) study...
December 25, 2023: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38132193/analysis-of-periprocedural-x-ray-exposure-in-transarterial-radioembolization-with-glass-or-resin-microspheres
#19
JOURNAL ARTICLE
Constantin Ehrengut, Johanna Vogt, Jakob Leonhardi, Emma Carabenciov, Felix Teske, Florian van Boemmel, Thomas Berg, Daniel Seehofer, Thomas Lincke, Osama Sabri, Holger Gößmann, Timm Denecke, Sebastian Ebel
Background : Transarterial Radioembolization (TARE) is an effective treatment option for both primary and secondary liver malignancies. However, challenging anatomical conditions can lead to prolonged fluoroscopy times (FT), elevated doses of periprocedural X-radiation (DAP), and increased use of contrast agents (CAs). In this study, we examined the influence of our radiologists' experience and the choice of microspheres on X-ray exposure and CA doses in TARE. Material and Methods : Datasets comprising 161 TARE and 164 preprocedural evaluation angiographies (TARE-EVA) were analyzed...
December 6, 2023: Diagnostics
https://read.qxmd.com/read/38106267/comparison-of-aortic-blood-flow-rotational-direction-in-healthy-volunteers-and-patients-with-bicuspid-aortic-valves-using-volumetric-velocity-sensitive-cardiovascular-magnetic-resonance-imaging
#20
JOURNAL ARTICLE
Sebastian Ebel, Benjamin Köhler, Abhinav Aggarwal, Bernhard Preim, Benjamin Behrendt, Bernd Jung, Robin F Gohmann, Boris Riekena, Michael Borger, Philipp Lurz, Timm Denecke, Matthias Grothoff, Matthias Gutberlet
BACKGROUND: The rotational direction (RD) of helical blood flow can be classified as either a clockwise (RD+ ) or counter-clockwise (RD- ) flow. We hypothesized that this simple classification might not be sufficient for analysis in vivo and a simultaneous existence of RD+/- may occur. We utilized volumetric velocity-sensitive cardiovascular magnetic resonance imaging (4D flow MRI) to analyze rotational blood flow in the thoracic aorta. METHODS: Forty volunteers (22 females; mean age, 41±16 years) and seventeen patients with bicuspid aortic valves (BAVs) (9 females; mean age, 42±14 years) were prospectively included...
December 1, 2023: Quantitative Imaging in Medicine and Surgery
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