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Hanh H Nguyen, Phillip Wong, Boyd J Strauss, Peter R Ebeling, Frances Milat, Amanda Vincent
Context: Turner Syndrome (TS) is associated with short stature, gonadal failure, and fractures. Spinal trabecular bone score (TBS) is a novel bone imaging modality that has not been evaluated in TS. Objective: To evaluate TBS in TS, and its association with BMD, prevalent fracture and its risk factors. Design and setting: Longitudinal study of TS from a single tertiary hospital between 2006-2017. Patients or Other Participants: Fifty-eight TS subjects aged 20-49 years who underwent DXA...
July 17, 2018: Journal of Clinical Endocrinology and Metabolism
Ebele Onuigbo, Joy Iseghohimhen, Kennedy Chah, Moses Gyang, Anthony Attama
Oral fowl typhoid (FT) vaccine is necessary for improved flock vaccinations and economic growth. This study was undertaken to evaluate the immune responses of birds given oral fowl typhoid vaccine coated with chitosan/alginate microparticles and comparing it with the conventional subcutaneous route of administration. Preliminary studies were done to evaluate the particle size, encapsulation efficiency and agglutination. Sixty day-old chicks were divided into three groups of twenty birds each. This comprised a negative control group NEG 451 (non-vaccinated and non-challenged used as control for cytokine quantification), SC 634 (live 9R vaccine by the injection route) and OCV 567 (live 9R vaccine coated with chitosan/alginate microparticles)...
July 12, 2018: Vaccine
Ashish K Sharma, Nigel D Toussaint, Grahame J Elder, Chamith S Rajapakse, Stephen G Holt, Paul Baldock, Patricia L Robertson, Peter R Ebeling, Olivia R Sorci, Rosemary Masterson
Bone disease in kidney transplant recipients (KTRs) is characterised by bone mineral density (BMD) loss but bone microarchitecture changes are poorly defined. In this prospective cohort study, we evaluated bone microarchitecture using non-invasive imaging modalities; high-resolution magnetic resonance imaging (MRI), peripheral quantitative computed tomography (pQCT), dual energy X-ray absorptiometry (DXA) and the trabecular bone score (TBS) following kidney transplantation. Eleven KTRs (48.3±11.2 years) underwent MRI (tibia), pQCT (radius) and DXA at baseline and 12 months post-transplantation...
July 8, 2018: Clinical Transplantation
Jeffrey P Jacobs, Christo I Tchervenkov, Giovanni Stellin, Hiromi Kurosawa, Constantine Mavroudis, Marcelo B Jatene, Zohair Al-Halees, Sertac M Cicek, Nestor F Sandoval, Carl L Backer, Jorge Cervantes, Joseph A Dearani, Tjark Ebels, Frank Edwin, Kirsten Finucane, Jose Fragata, Krishna S Iyer, Robin H Kinsley, James K Kirklin, Christian Kreutzer, Jinfen Liu, Bohdan Maruszewski, James D St Louis, George E Sarris, Richard A Jonas
The World Society for Pediatric and Congenital Heart Surgery (WSPCHS) is the largest professional organization in the world dedicated to pediatric and congenital heart surgery. The purpose of this article is to document the first decade of the history of WSPCHS from its formation in 2006, to summarize the current status of WSPCHS, and to consider the future of WSPCHS. The WSPCHS was incorporated in Canada on April 7, 2011, with a head office in Montreal, Canada. The vision of the WSPCHS is that every child born anywhere in the world with a congenital heart defect should have access to appropriate medical and surgical care...
July 2018: World Journal for Pediatric & Congenital Heart Surgery
Jennifer F Hoy, Robyn Richardson, Peter R Ebeling, Jhon Rojas, Nicholas Pocock, Stephen J Kerr, Esteban Martinez, Andrew Carr
OBJECTIVE: To compare the effects of switching tenofovir disoproxil fumarate (TDF) or treatment with an intravenous bisphosphonate on bone mineral density (BMD) in HIV-positive adults with low bone mass. DESIGN: Two-year, randomised, open-label study at 10 sites in Australia and Spain. PARTICIPANTS: Of 112 adults on TDF-based antiretroviral therapy (ART) screened, 87 with low BMD (T-score < -1.0 at hip or spine by dual-energy x-ray absorptiometry) and undetectable plasma HIV viral load were randomised to either switch TDF to another active antiretroviral drug or to continue TDF-based ART and receive intravenous zoledronic acid (ZOL) 5 mg annually for 2 years...
June 20, 2018: AIDS
Daniel Ebeling, Marina Šekutor, Marvin Stiefermann, Jalmar Tschakert, Jeremy E P Dahl, Robert M K Carlson, André Schirmeisen, Peter R Schreiner
Deciphering absolute configuration of a single molecule by direct visual inspection is the next step in compound identification, with far-reaching implications for medicinal chemistry, pharmacology, and natural product synthesis. We demonstrate the feasibility of this approach utilizing low temperature atomic force microscopy (AFM) with a CO-functionalized tip to determine the absolute configuration and orientation of a single, adsorbed [123]tetramantane molecule, the smallest chiral diamondoid. We differentiate between single enantiomers on Cu(111) by direct visual inspection, and furthermore identify molecular dimers and molecular clusters...
June 20, 2018: Nature Communications
Anna-Maria Kuivalainen, Freja Ebeling, Per Rosenberg
Background and purpose Local infiltration anaesthesia is frequently painful due to low pH of the used anaesthetics, such as lidocaine. Usually pH of the solution is near 4.0, which causes tissue irritation and excitation of the pain mediating nerve endings. Warming and buffering the local anaesthetic solution have been shown to reduce the patient's experience of pain and unpleasantness during infiltration. Buffering reduces the dissociation of the local anaesthetic molecule and may enhance the anaesthetic's entrance into nerve cells...
December 29, 2017: Scandinavian Journal of Pain
Anna-Maria Kuivalainen, Freja Ebeling, Eira Poikonen, Per H Rosenberg
Background and aims Bone marrow aspiration and/or biopsy (BMAB), performed under local anaesthesia in adults, is a common and often painful procedure. Anxiety is known to intensify pain during the procedure. Nitrous oxide (N2O), known for its sedative and analgesic benefit in various short medical procedures and labour pain, could be advantageous also for pain relief during bone marrow examination. N2O acts rapidly and is eliminated in a couple of minutes once the inhalation is stopped, and occasional side effects (e...
December 29, 2017: Scandinavian Journal of Pain
Anne Fünfhaus, Josefine Göbel, Julia Ebeling, Henriette Knispel, Eva Garcia-Gonzalez, Elke Genersch
American Foulbrood is a worldwide distributed, fatal disease of the brood of the Western honey bee (Apis mellifera). The causative agent of this fatal brood disease is the Gram-positive, spore-forming bacterium Paenibacillus larvae, which can be classified into four different genotypes (ERIC I-IV), with ERIC I and II being the ones isolated from contemporary AFB outbreaks. P. larvae is a peritrichously flagellated bacterium and, hence, we hypothesized that P. larvae is capable of coordinated and cooperative multicellular behaviors like swarming motility and biofilm formation...
June 11, 2018: Scientific Reports
N H Ebel, P Rosenthal
No abstract text is available yet for this article.
June 2018: Alimentary Pharmacology & Therapeutics
Eleanor P Thong, Madhuni Herath, David R Weber, Sanjeeva Ranasinha, Peter R Ebeling, Frances Milat, Helena Teede
BACKGROUND: Type 1 diabetes mellitus (T1DM) is associated with skeletal fragility. While previous meta-analyses have demonstrated an increased risk of fracture in individuals with T1DM, little is known about fracture risk in T1DM, in the absence of age-related confounders. AIMS: To determine the risk of fracture in young and middle-aged adults with T1DM aged 18-50 years old. DESIGN: Systematic review and meta-analysis. DATA SOURCES: Ovid MEDLINE, PubMed, EMBASE, EBM reviews and relevant conference abstracts...
June 7, 2018: Clinical Endocrinology
Ashish K Sharma, Nigel D Toussaint, Grahame J Elder, Rosemary Masterson, Stephen G Holt, Patricia L Robertson, Peter R Ebeling, Paul Baldock, Rhiannon C Miller, Chamith S Rajapakse
BACKGROUND: Chronic kidney disease (CKD) adversely affects bone microarchitecture and increases fracture risk. Historically, bone biopsy has been the 'gold standard' for evaluating renal bone disease but is invasive and infrequently performed. High-resolution magnetic resonance imaging (MRI) quantifies bone microarchitecture noninvasively. In patients with CKD, it has not been compared with results derived from bone biopsy or with imaging using dual energy X-ray absorptiometry (DXA). METHODS: Fourteen patients with end-stage kidney disease (ESKD) underwent MRI at the distal tibia, bone mineral density (BMD) by dual energy X-ray absorptiometry (DXA; hip and spine) and transiliac bone biopsies with histomorphometry and microcomputed tomography (micro-CT)...
May 31, 2018: Bone
M Ebeling, W Lüdemann, J Frisius, M Karst, I Schedel, V Gerganov, A Samii, R Fahlbusch
OBJECTIVE: To evaluate the effectiveness of intraoperative and postoperative intermittent pneumatic compression (IPC) as a method used to decrease the incidence of deep venous thrombosis (DVT), in comparison to the standard use of graduated compression stockings, low-molecular weight heparin (LMWH) and physiotherapy during the hospital stay. All patients in this study underwent intracranial surgery for glioblastoma multiforme (GBM) using intraoperative magnetic resonance imaging (MRI) guidance...
May 30, 2018: Neuro-Chirurgie
Heleen Lameijer, Ymkje J van Slooten, Monique R M Jongbloed, Martijn A Oudijk, Marlies A M Kampman, Arie P van Dijk, Marco C Post, Barbara J Mulder, Krystyna M Sollie, Dirk J van Veldhuisen, Tjark Ebels, Joost P van Melle, Petronella G Pieper
BACKGROUND: We evaluate pregnancy outcome and anticoagulation regimes in women with mechanical and biological prosthetic heart valves (PHV) for congenital heart disease. METHODS: Retrospective multicenter cohort studying pregnancy outcomes in an existing cohort of patients with PHV. RESULTS: 52 women had 102 pregnancies of which 78 pregnancies (46 women) ≥20 weeks duration (59 biological, 19 mechanical PHV). Miscarriages (n = 19, ≤20 weeks) occurred more frequently in women using anticoagulation (P < ...
May 23, 2018: International Journal of Cardiology
Ashish K Sharma, Nigel D Toussaint, Rosemary Masterson, Stephen G Holt, Chamith S Rajapakse, Peter R Ebeling, Sindhu T Mohanty, Paul Baldock, Grahame J Elder
BACKGROUND: Cortical bone is a significant determinant of bone strength and its deterioration contributes to bone fragility. Thin cortices and increased cortical porosity have been noted in patients with chronic kidney disease (CKD), but the "Turnover Mineralization Volume" classification of renal osteodystrophy does not emphasize cortical bone as a key parameter. We aimed to assess trabecular and cortical bone microarchitecture by histomorphometry and micro-CT in patients with CKD G5 and 5D (dialysis)...
May 23, 2018: American Journal of Nephrology
Alicia K Heath, Elizabeth J Williamson, Allison M Hodge, Peter R Ebeling, Darryl W Eyles, David Kvaskoff, Kerin O'Dea, Graham G Giles, Dallas R English
AIMS: Inverse associations between vitamin D status and risk of type 2 diabetes observed in epidemiological studies could be biased by confounding and reverse causality. We investigated the prospective association between vitamin D status and type 2 diabetes and the possible role of reverse causality. METHODS: We conducted a case-cohort study within the Melbourne Collaborative Cohort Study (MCCS), including a random sample of 628 participants who developed diabetes and a sex-stratified random sample of the cohort (n=1,884)...
May 18, 2018: Diabetes Research and Clinical Practice
Jasna Aleksova, Samantha Kurniawan, Mirna Vucak-Dzumhur, Peter Kerr, Peter R Ebeling, Frances Milat, Grahame J Elder
INTRODUCTION: Progressive chronic kidney disease (CKD) confers a marked increase in risk for vascular calcification, cardiovascular disease, fracture and mortality, with likely contributing factors including dysregulated bone metabolism and mineral homeostasis. In general population studies, increased vascular calcification is directly related to mortality and inversely related to bone mineral density (BMD) measured by dual-energy X-ray absorptiometry (DXA). In patients with CKD, abnormalities in turnover, mineralization and bone volume reduce the ability of DXA to predict fracture...
August 2018: Bone
Stephen J Mooney, Caroline Magee, Kolena Dang, Julie C Leonard, Jingzhen Yang, Frederick P Rivara, Beth E Ebel, Ali Rowhani-Rahbar, D Alex Quistberg
"Complete Streets" policies require transportation engineers to make provisions for pedestrians, cyclists and transit users. These policies may make bicycling safer for individual cyclists while increasing overall bicycle fatalities if more individuals cycle due to improved infrastructure. We merged county-level records of Complete Streets policies with Fatality Analysis Reporting System counts of cyclist fatalities occurring between January 2000 and December 2015. Because comprehensive county cycling estimates were not available, we used bicycle commute estimates from the American Community Survey and US Census as a proxy for the cycling population, and limited analysis to 183 counties (accounting for over half the US population) for which cycle commute estimates were consistently non-zero...
May 14, 2018: American Journal of Epidemiology
Seyedmojtaba Seyedmousavi, Sandra de M G Bosco, Sybren de Hoog, Frank Ebel, Daniel Elad, Renata R Gomes, Ilse D Jacobsen, Henrik E Jensen, An Martel, Bernard Mignon, Frank Pasmans, Elena Piecková, Anderson Messias Rodrigues, Karuna Singh, Vania A Vicente, Gudrun Wibbelt, Nathan P Wiederhold, Jacques Guillot
No abstract text is available yet for this article.
April 17, 2018: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
Ronald J Teufel, Anita B Shuler, Myla D Ebeling, Kristen Morella, Annie L Andrews
BACKGROUND AND OBJECTIVES: Asthma is a common reason for hospital readmission. The majority of children are not receiving adequate preventive care after discharge. Our objective is to decrease return visits to the emergency department (ED) or hospital for asthma through a series of interventions (eg, access to real-time claims data and structured follow-up phone calls) designed to increase preventive care. METHODS: We performed a single-site quality improvement project for children 2 to 17 years old discharged with asthma from January 2010 to March 2014...
May 2018: Hospital Pediatrics
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