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https://www.readbyqxmd.com/read/29679696/effect-of-neuromonitor-guided-titrated-care-on-brain-tissue-hypoxia-after-opioid-overdose-cardiac-arrest
#1
Jonathan Elmer, Katharyn L Flickinger, Maighdlin W Anderson, Allison Koller, Matthew Sundermann, Cameron Dezfulian, David O Okonkwo, Lori A Shutter, David Salcido, Clifton W Callaway, James J Menegazzi
INTRODUCTION: Brain tissue hypoxia may contribute to preventable secondary brain injury after cardiac arrest. We developed a porcine model of opioid overdose cardiac arrest and post-arrest care including invasive, multimodal neurological monitoring of regional brain physiology. We hypothesized brain tissue hypoxia is common with usual post-arrest care and can be prevented by modifying mean arterial pressure (MAP) and arterial oxygen concentration (PaO2 ). METHODS: We induced opioid overdose and cardiac arrest in sixteen swine, attempted resuscitation after 9 minutes of apnea, and randomized resuscitated animals to three alternating 6-hour blocks of standard or titrated care...
April 18, 2018: Resuscitation
https://www.readbyqxmd.com/read/29679508/motion-compensated-image-reconstruction-vs-post-reconstruction-correction-in-respiratory-binned-spect-with-standard-and-reduced-dose-acquisitions
#2
Chao Song, Yongyi Yang, Wenyuan Qi, Miles N Wernick, P Hendrik Pretorius, Michael A King
PURPOSE: Cardiac perfusion images in single photon emission computed tomography (SPECT) can suffer from respiratory motion blur. We investigated a reconstruction approach for correcting respiratory motion in respiratory-binned acquisitions and assessed the benefit of this approach in both standard dose and reduced dose. METHODS: We modeled the acquired data from different respiratory bins by a joint probability distribution which was parameterized with respect to a common reference bin...
April 21, 2018: Medical Physics
https://www.readbyqxmd.com/read/29674616/quantifying-mri-frequency-shifts-due-to-structures-with-anisotropic-magnetic-susceptibility-using-pyrolytic-graphite-sheet
#3
Matthew J Cronin, Richard Bowtell
Magnetic susceptibility is an important source of contrast in magnetic resonance imaging (MRI), with spatial variations in the susceptibility of tissue affecting both the magnitude and phase of the measured signals. This contrast has generally been interpreted by assuming that tissues have isotropic magnetic susceptibility, but recent work has shown that the anisotropic magnetic susceptibility of ordered biological tissues, such as myelinated nerves and cardiac muscle fibers, gives rise to unexpected image contrast...
April 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29670885/integrative-bioinformatics-approaches-for-identification-of-drug-targets-in-hypertension
#4
Daiane Hemerich, Jessica van Setten, Vinicius Tragante, Folkert W Asselbergs
High blood pressure or hypertension is an established risk factor for a myriad of cardiovascular diseases. Genome-wide association studies have successfully found over nine hundred loci that contribute to blood pressure. However, the mechanisms through which these loci contribute to disease are still relatively undetermined as less than 10% of hypertension-associated variants are located in coding regions. Phenotypic cell-type specificity analyses and expression quantitative trait loci show predominant vascular and cardiac tissue involvement for blood pressure-associated variants...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29669504/atrial-fibrillation-in-autoimmune-rheumatic-diseases-from-the-pathogenesis-to-the-treatment
#5
Giuseppe Ciconte, Manuel Conti, Martina Evangelista, Carlo Pappone
BACKGROUND: Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia in the general population and is associated with an increased number of adverse outcomes. The onset and maintenance of this arrhythmia requires a trigger event and the presence of a predisposing substrate. Atrial fibrosis, a major characteristic of AF-related structural remodeling, represents a process closely related to inflammation as demonstrated by emerging evidence. Aim of this article is to review the evidence linking AF to systemic autoimmune diseases...
April 17, 2018: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/29668909/effect-of-ephedrine-on-gastric-conduit-perfusion-measured-by-laser-speckle-contrast-imaging-after-esophagectomy-a-prospective-in-vivo-cohort-study
#6
S M Jansen, D M de Bruin, M I van Berge Henegouwen, P R Bloemen, S D Strackee, D P Veelo, T G van Leeuwen, S S Gisbertz
Compromised perfusion due to ligation of arteries and veins in esophagectomy with gastric tube reconstruction often (5-20%) results in necrosis and anastomotic leakage, which relate to high morbidity and mortality (3-4%). Ephedrine is used widely in anesthesia to treat intraoperative hypotension and may improve perfusion by the increase of cardiac output and mean arterial pressure (MAP). This study tests the effect of ephedrine on perfusion of the future anastomotic site of the gastric conduit, measured by laser speckle contrast imaging (LSCI)...
April 13, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29668674/the-influences-of-the-m2r-girk4-rgs6-dependent-parasympathetic-pathway-on-electrophysiological-properties-of-the-mouse-heart
#7
Kanchan Kulkarni, Xueyi Xie, Ezequiel Marron Fernandez de Velasco, Allison Anderson, Kirill A Martemyanov, Kevin Wickman, Elena G Tolkacheva
A large body of work has established the prominent roles of the atrial M2R-IKACh signaling pathway, and the negative regulatory protein RGS6, in modulating critical aspects of parasympathetic influence on cardiac function, including pace-making, heart rate (HR) variability (HRV), and atrial arrhythmogenesis. Despite increasing evidence of its innervation of the ventricles, and the expression of M2R, IKACh channel subunits, and RGS6 in ventricle, the effects of parasympathetic modulation on ventricular electrophysiology are less clear...
2018: PloS One
https://www.readbyqxmd.com/read/29667208/the-use-of-cardiac-ct-alone-to-exclude-left-atrial-thrombus-before-atrial-fibrillation-ablation-efficiency-safety-and-cost-analysis
#8
Wassim Mosleh, Ali Sheikh, Zaid Said, Mohamed A Abdel-Aal, Siri Gadde, Tanvi Shah, Michael F Wilson, Hiroko Beck, Chee Kim, Umesh C Sharma
BACKGROUND: Atrial fibrillation (AF) is a growing financial burden on the healthcare system. Cardiac computed tomographic angiography (CCTA) is needed for pulmonary vein mapping before AF ablation (AFA). CCTA has shown to be an alternative to transesophageal echocardiogram (TEE) to rule-out left atrial appendage thrombus (LAAT) pre-AFA. We aim to examine the safety, cost-effectiveness, and time-efficiency of utilizing CCTA alone to rule out LAAT before AFA. METHODS: We prospectively screened patients with paroxysmal AF undergoing cryoablation...
April 17, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29663562/atrial-fibrillation-ablation-using-cryoballoon-technology-recent-advances-and-practical-techniques
#9
REVIEW
Shaojie Chen, Boris Schmidt, Stefano Bordignon, Fabrizio Bologna, Laura Perrotta, Takahiko Nagase, K R Julian Chun
Atrial fibrillation (AF) affects 1-2% of the population, and its prevalence is estimated to double in the next 50 years as the population ages. AF results in impaired patients' life quality, deteriorated cardiac function and even increased mortality. Antiarrhythmic drugs frequently fail to restore sinus rhythm. Catheter ablation is a valuable treatment approach for AF, even as a first-line therapy strategy in selected patients. Effective electrical pulmonary vein isolation (PVI) is the cornerstone of all AF ablation strategies...
April 16, 2018: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29660191/in-vivo-human-sock-mapping-validation-of-a-simple-model-that-explains-unipolar-electrogram-morphology-in-relation-to-conduction-repolarization-dynamics
#10
Michele Orini, Peter Taggart, Pier D Lambiase
INTRODUCTION: The unipolar electrogram (UEG) provides local measures of cardiac activation and repolarization and is an important translational link between patient and laboratory. A simple theoretical model of the UEG was previously proposed and tested in-silico. METHOD AND RESULTS: The aim of this study was to use epicardial sock-mapping data to validate the simple model's predictions of unipolar electrogram morphology in the in-vivo human heart. The simple model conceptualizes the UEG as the difference between a local cardiac action potential and a position-independent component representing remote activity, which is defined as the average of all action potentials...
April 16, 2018: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29659631/the-hemodynamic-effects-of-intravenous-paracetamol-acetaminophen-vs-normal-saline-in-cardiac-surgery-patients-a-single-center-placebo-controlled-randomized-study
#11
Elizabeth Chiam, Rinaldo Bellomo, Leonid Churilov, Laurence Weinberg
The hemodynamic effects of intravenous (IV) paracetamol in patients undergoing cardiac surgery are unknown. We performed a prospective single center placebo controlled randomized study with parallel group design in adult patients undergoing elective cardiac surgery. Participants received paracetamol (1 gram) IV or placebo (an equal volume of 0.9% saline) preoperatively followed by two postoperative doses 6 hours apart. The primary endpoint was the absolute change in systolic (SBP) 30 minutes after the preoperative infusion, analysed using an ANCOVA model...
2018: PloS One
https://www.readbyqxmd.com/read/29657683/radiation-protection-knowledge-attitude-and-practice-kap-in-interventional-radiology
#12
Fatemeh Shabani, Hadi Hasanzadeh, Alireza Emadi, Majid Mirmohammadkhani, Ahmad Bitarafan-Rajabi, Ali Abedelahi, Mitra Bokharaeian, Hamed Masoumi, Danial Seifi, Tahereh Khani, Mohamad Sanchooli, Shima Moshfegh, Abbas Ziari
Objectives: Due to increasing cardiac disease and its mortality rate, the frequency of cardiac imaging has grown and, as a result, interventional cardiologists potentially receive high radiation doses in cardiac examinations. This study aimed to assess the knowledge, attitude, and practice (KAP) level of radiation protection (RP) among interventional radiology staff in Iranian health care centers across the country. Methods: We used a validated questionnaire survey consisting of 30 multiple-choice questions to perform a cross-sectional study...
March 2018: Oman Medical Journal
https://www.readbyqxmd.com/read/29657146/absence-of-fibrosis-and-inflammation-by-cardiac-magnetic-resonance-imaging-in-rheumatoid-arthritis-patients-with-low-to-moderate-disease-activity
#13
William Bradham, Michelle J Ormseth, Comfort Elumogo, Srikanth Palanisamy, Chia-Ying Liu, Mark A Lawson, Jonathan H Soslow, Nadine Kawel-Boehm, David A Bluemke, C Michael Stein
OBJECTIVE: The prevalence of heart failure is increased 2-fold in patients with rheumatoid arthritis (RA); this is not explained by ischemic heart disease or other risk factors for heart failure. We hypothesized that in patients with RA without known heart disease, cardiac magnetic resonance imaging (cMRI) would detect altered cardiac structure, function, and fibrosis. METHODS: We performed 1.5-T cMRI in 59 patients with RA and 56 controls frequency-matched for age, race, and sex, and compared cMRI indices of structure, function, and fibrosis [late gadolinium enhancement (LGE), native T1 mapping, and extracellular volume (ECV)] using Mann-Whitney U tests and linear regression, adjusting for age, race, and sex...
April 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29655977/dexmedetomidine-or-fentanyl-cardiovascular-stability-and-analgesia-during-propofol-ketamine-total-intravenous-anaesthesia-in-experimental-pigs
#14
Andreas Lervik, Joanna Raszplewicz, Birgit Ranheim, Susanna Solbak, Simen F Toverud, Henning A Haga
OBJECTIVE: To compare cardiovascular function and response to nociception during total intravenous anaesthesia in pigs with propofol, ketamine and either dexmedetomidine or fentanyl administered as a continuous infusion. STUDY DESIGN: Blinded, randomized, balanced, crossover study ANIMALS: Eight immunocastrated male, mixed breed pigs with a mean ± standard deviation body weight of 26.4 ± 1.9 kg for dexmedetomidine and 27.5 ± 3.8 kg for fentanyl treatment...
December 5, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/29653251/probabilistic-guidance-for-catheter-tip-motion-in-cardiac-ablation-procedures
#15
Mihaela Am Constantinescu, Su-Lin Lee, Sabine Ernst, Apit Hemakom, Danilo Mandic, Guang-Zhong Yang
Radiofrequency catheter ablation is one of the commonly available therapeutic methods for patients suffering from cardiac arrhythmias. The prerequisite of successful ablation is sufficient energy delivery at the target site. However, cardiac and respiratory motion, coupled with endocardial irregularities, can cause catheter drift and dispersion of the radiofrequency energy, thus prolonging procedure time, damaging adjacent tissue, and leading to electrical reconnection of temporarily ablated regions. Therefore, positional accuracy and stability of the catheter tip during energy delivery is of great importance for the outcome of the procedure...
March 23, 2018: Medical Image Analysis
https://www.readbyqxmd.com/read/29652390/integrated-catheter-for-simultaneous-radio-frequency-ablation-and-optoacoustic-monitoring-of-lesion-progression
#16
Johannes Rebling, Francisco Javier Oyaga Landa, Xosé Luís Deán-Ben, Alexandre Douplik, Daniel Razansky
Radio frequency (RF) catheter ablation is commonly used to eliminate dysfunctional cardiac tissue by heating via an alternating current. Clinical outcomes are highly dependent on careful anatomical guidance, electrophysiological mapping, and careful RF power titration during the procedure. Yet, current treatments rely mainly on the expertise of the surgeon to assess lesion formation, causing large variabilities in the success rate. We present an integrated catheter design suitable for simultaneous RF ablation and real-time optoacoustic monitoring of the forming lesion...
April 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/29629022/impact-of-a-geometric-correction-for-proximal-flow-constraint-on-the-assessment-of-mitral-regurgitation-severity-using-the-proximal-flow-convergence-method
#17
Jeong Yoon Jang, Joon-Won Kang, Dong Hyun Yang, Sahmin Lee, Byung Joo Sun, Dae-Hee Kim, Jong-Min Song, Duk-Hyun Kang, Jae-Kwan Song
Background: Overestimation of the severity of mitral regurgitation (MR) by the proximal isovelocity surface area (PISA) method has been reported. We sought to test whether angle correction (AC) of the constrained flow field is helpful to eliminate overestimation in patients with eccentric MR. Methods: In a total of 33 patients with MR due to prolapse or flail mitral valve, both echocardiography and cardiac magnetic resonance image (CMR) were performed to calculate regurgitant volume (RV)...
March 2018: Journal of Cardiovascular Ultrasound
https://www.readbyqxmd.com/read/29627741/effects-of-renal-sympathetic-denervation-on-myocardial-structure-function-and-perfusion-a-serial-cmr-study
#18
Sinny Delacroix, Ramesh G Chokka, Adam J Nelson, Dennis T Wong, Stephen Pederson, Joanne Nimmo, Adil Rajwani, Kerry Williams, Karen S Teo, Stephen G Worthley
BACKGROUND AND AIMS: Echocardiographic studies have shown improvements in cardiac indices associated with renal sympathetic denervation (RDN), however, the benefits on myocardial perfusion have never been assessed. This trial was designed to study the effects of RDN on myocardial perfusion using cardiac magnetic resonance (CMR) imaging. METHODS: A total of 14 patients with resistant hypertension were recruited for RDN and myocardial perfusion, alongside other CMR indices, was assessed at baseline and at 6 months...
March 10, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29625438/changes-in-myosin-heavy-chain-isoforms-along-the-length-of-orbital-fibers-in-rabbit-extraocular-muscle
#19
Christine A Lucas, Hannah S M Rhee, Joseph F Y Hoh
Purpose: Extraocular muscles express 10 myosin heavy chain (MyHC) isoforms that cater for a wide range of contractile speeds. We aim to characterize the variations in MyHC expression along the length of singly (SIFs) and multiply innervated fibers (MIFs) in the orbital layer of rabbit superior rectus muscle. Methods: Monospecific antibodies to nine MyHCs, including an anti-slow-tonic antibody characterized here were used to immunohistochemically map variations in MyHC distribution in serial sections along the muscle's full length...
March 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29625195/idiopathic-premature-ventricular-complexes-originating-from-the-distal-great-cardiac-vein-clinical-cardiac-and-electrophysiological-characteristics-and-catheter-ablation-outcome
#20
Wenkui Lv, Xianhui Zhou, Gulinuer Yiming, Ling Zhang, Qina Zhou, Yaodong Li, Qiang Xing, Jianghua Zhang, Yanmei Lu, Hongli Wang, Guiqiu Cao, Baopeng Tang
AIMS: Although catheter ablation for idiopathic ventricular arrhythmia (VA) has been generally well-established, VA originating from the great cardiac vein (GCV) may be clinically challenging due to its epicardial origin, proximity to coronary arteries and limited accessibility. The purpose of this study was to explore its electrophysiological characteristics and identify effective mapping/ablation strategies for idiopathic premature ventricular complexes (PVCs) originating from the GCV...
April 3, 2018: Life Sciences
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