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https://www.readbyqxmd.com/read/28060857/pseudomonas-aeruginosa-ventilator-associated-pneumonia-induces-lung-injury-through-tnf-%C3%AE-c-jun-nh2-terminal-kinase-pathways
#1
Ying-Wei Yang, Yu-Zhen Jiang, Ching-Mei Hsu, Lee-Wei Chen
Ventilator-associated pneumonia (VAP) is a common nosocomial infection among intensive care unit (ICU) patients. Pseudomonas aeruginosa (PA) is the most common multidrug-resistant Gram-negative pathogen and VAP caused by PA carries a high rate of morbidity and mortality. This study examined the molecular mechanism of PA VAP-induced lung injury. C57BL/6 wild-type (WT) mice and JNK1 knockout (JNK1-/-) mice received mechanical ventilation (MV) for 3 h at 2 days after receiving nasal instillation of PA. The WT and JNK1-/- mice also received MV after the induction of lung injury by instillation of supernatants from PA-stimulated alveolar macrophages (AMs)...
2017: PloS One
https://www.readbyqxmd.com/read/28025061/understanding-resident-performance-mindfulness-and-communication-in-critical-care-rotations
#2
Kevin Real, Katelyn Fields-Elswick, Andrew C Bernard
OBJECTIVE: Evidence from the medical literature suggests that surgical trainees can benefit from mindful practices. Surgical educators are challenged with the need to address resident core competencies, some of which may be facilitated by higher levels of mindfulness. This study explores whether mindful residents perform better than their peers as members of the health care team. DESIGN: This study employed a multiphase, multimethod design to assess resident mindfulness, communication, and clinical performance...
December 23, 2016: Journal of Surgical Education
https://www.readbyqxmd.com/read/28024549/temporary-mechanical-circulatory-support-in-cardiac-critical-care-a-state-of-the-art-review-and-algorithm-for-device-selection
#3
REVIEW
A Dave Nagpal, Rohit K Singal, Rakesh C Arora, Yoan Lamarche
With more than 60 years of continuous development and improvement, a variety of temporary mechanical circulatory support (MCS) devices and implantation strategies exist, each with unique advantages and disadvantages. A thorough understanding of each available device is essential for optimizing patient outcomes in a fiscally responsible manner. In this state of the art review we examine the entire range of commonly available peripheral and centrally cannulated temporary MCS devices, including intra-aortic balloon pumps, the Impella (Abiomed, Danvers, MA) family of microaxial pumps, the TandemHeart (CardiacAssist Inc, Pittsburg, PA) pump and percutaneous cannulas, centrally cannulated centrifugal pumps such as the CentriMag (Thoratec Corp, Pleasanton, CA/St Jude Medical, St Paul, MN/Abbott Laboratories, Abbott Park, IL) and Rotaflow (Maquet Holding BV & Co KG, Rastatt Germany), and extracorporeal membrane oxygenation...
January 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28008778/physical-activity-during-and-after-adjuvant-treatment-for-breast-cancer
#4
Maria Browall, Sara Mijwel, Helen Rundqvist, Yvonne Wengström
BACKGROUND: In oncology, physical activity (PA) is recognized to improve psychological and physiological functions. Motivating women with breast cancer to sustain a physically active lifestyle is important for promoting positive health after diagnosis. To review and synthesize what is known about how women with breast cancer experience supervised and unsupervised PA during and after adjuvant treatment. PubMed, PsycINFO, and CINAHL were searched, yielding 994 citations. The final review included 17 articles published between 2004 and 2014 in English...
December 1, 2016: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/28000452/phase-angle-and-onodera-s-prognostic-nutritional-index-in-critically-ill-patients
#5
Karina Marques Vermeulen, Leilane Lilian Araújo Leal, Mariana Câmara Martins Bezerra Furtado, Sancha Helena de Lima Vale, Lúcia Leite Lais
INTRODUCTION: Assessing severity and nutritional prognosis in critical patients has become increasingly important in recent years, since these parameters are related to morbidity/mortality and used to guide therapeutic options. OBJECTIVE: Determine nutritional prognosis through the Phase Angle (PA) and Onodera's Prognostic Nutritional Index (OPNI) and its relationship with severity, hospitalization time and mortality of critically ill patients. METHODS: Descriptive cross-sectional study, involving adult patients hospitalized in an Intensive Care Unit (ICU)...
November 29, 2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/27942002/the-impact-of-adding-a-physician-assistant-to-a-critical-care-outreach-team
#6
Hayley B Gershengorn, Yunchao Xu, Carri W Chan, Mor Armony, Michelle N Gong
RATIONALE: Hospitals are increasingly using critical care outreach teams (CCOTs) to respond to patients deteriorating outside intensive care units (ICUs). CCOT staffing is variable across hospitals and optimal team composition is unknown. OBJECTIVES: To assess whether adding a critical care medicine trained physician assistant (CCM-PA) to a critical care outreach team (CCOT) impacts clinical and process outcomes. METHODS: We performed a retrospective study of two cohorts-one with a CCM-PA added to the CCOT (intervention hospital) and one with no staffing change (control hospital)-at two facilities in the same system...
2016: PloS One
https://www.readbyqxmd.com/read/27918408/full-practice-authority-for-nurse-practitioners
#7
Deborah Dillon, Faye Gary
Implementation of the Affordable Care Act (2010) enabled more than 30 million people to have new access to primary care services. On the basis of current utilization patterns, demand for primary care providers is expected to grow more rapidly than physician supply. This imbalance is expected to worsen, as the aging population requires more health care resources. In addition, more patients are requiring critical care services and physician numbers are not keeping with this growing need. Restrictions on resident physician practice hours have impacted inpatient care as well...
January 2017: Nursing Administration Quarterly
https://www.readbyqxmd.com/read/27413813/broadband-phase-sensitive-single-inp-nanowire-photoconductive-terahertz-detectors
#8
Kun Peng, Patrick Parkinson, Jessica L Boland, Qian Gao, Yesaya C Wenas, Christopher L Davies, Ziyuan Li, Lan Fu, Michael B Johnston, Hark H Tan, Chennupati Jagadish
Terahertz time-domain spectroscopy (THz-TDS) has emerged as a powerful tool for materials characterization and imaging. A trend toward size reduction, higher component integration, and performance improvement for advanced THz-TDS systems is of increasing interest. The use of single semiconducting nanowires for terahertz (THz) detection is a nascent field that has great potential to realize future highly integrated THz systems. In order to develop such components, optimized material optoelectronic properties and careful device design are necessary...
August 10, 2016: Nano Letters
https://www.readbyqxmd.com/read/27335208/physical-activity-prescription-a-critical-opportunity-to-address-a-modifiable-risk-factor-for-the-prevention-and-management-of-chronic-disease-a-position-statement-by-the-canadian-academy-of-sport-and-exercise-medicine
#9
Jane S Thornton, Pierre Frémont, Karim Khan, Paul Poirier, Jonathon Fowles, Greg D Wells, Renata J Frankovich
Non-communicable disease is a leading threat to global health. Physical inactivity is a large contributor to this problem; in fact, the WHO ranks it as the fourth leading risk factor for overall morbidity and mortality worldwide. In Canada, at least 4 of 5 adults do not meet the Canadian Physical Activity Guidelines of 150 min of moderate-to-vigorous physical activity per week. Physicians play an important role in the dissemination of physical activity (PA) recommendations to a broad segment of the population, as over 80% of Canadians visit their doctors every year and prefer to get health information directly from them...
September 2016: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/27332501/examining-the-effects-of-an-interprofessional-crew-resource-management-training-intervention-on-perceptions-of-patient-safety
#10
Wan-Ting Wu, Yung-Lung Wu, Shaw-Min Hou, Chun-Mei Kang, Chi-Hung Huang, Yu-Ju Huang, Victoria Yue An Wang, Pa-Chun Wang
This article reports the results from a study that employed an interprofessional crew resource management (CRM) education programme in the emergency and critical care departments. The study aimed to investigate the effectiveness of this intervention of participants' satisfaction and safety attitude changes using a satisfaction questionnaire and the Human Factors Attitude Survey (HFAS). Overall, participants responded positively to the CRM training-93.4% were satisfied, 93.1% agreed that it enhanced patient safety and care quality, 85...
July 2016: Journal of Interprofessional Care
https://www.readbyqxmd.com/read/27283733/smoke-inhalation-increases-intensive-care-requirements-and-morbidity-in-paediatric-burns
#11
Alethea Tan, Sarah Smailes, Thessa Friebel, Ashish Magdum, Quentin Frew, Naguib El-Muttardi, Peter Dziewulski
Burn survival has improved with advancements in fluid resuscitation, surgical wound management, wound dressings, access to antibiotics and nutritional support for burn patients. Despite these advancements, the presence of smoke inhalation injury in addition to a cutaneous burn still significantly increases morbidity and mortality. The pathophysiology of smoke inhalation has been well studied in animal models. Translation of this knowledge into effectiveness of clinical management and correlation with patient outcomes including the paediatric population, is still limited...
August 2016: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/27221673/evaluation-of-bioelectrical-impedance-analysis-in-critically-ill-patients-results-of-a-multicenter-prospective-study
#12
Adam Kuchnia, Carrie Earthman, Levi Teigen, Abigail Cole, Marina Mourtzakis, Michael Paris, Willem Looijaard, Peter Weijs, Heleen Oudemans-van Straaten, Gregory Beilman, Andrew Day, Roger Leung, Charlene Compher, Rupinder Dhaliwal, Sarah Peterson, Hannah Roosevelt, Daren K Heyland
BACKGROUND: In critically ill patients, muscle loss is associated with adverse outcomes. Raw bioelectrical impedance analysis (BIA) parameters (eg, phase angle [PA] and impedance ratio [IR]) have received attention as potential markers of muscularity, nutrition status, and clinical outcomes. Our objective was to test whether PA and IR could be used to assess low muscularity and predict clinical outcomes. METHODS: Patients (≥18 years) having an abdominal computed tomography (CT) scan and admitted to intensive care underwent multifrequency BIA within 72 hours of scan...
May 24, 2016: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27197133/quality-performance-of-laboratory-testing-in-pharmacies-a-collaborative-evaluation
#13
Martina Zaninotto, Giorgia Miolo, Adriano Guiotto, Silvia Marton, Mario Plebani
BACKGROUND: The quality performance and the comparability between results of pharmacies point-of-care-testing (POCT) and institutional laboratories have been evaluated. METHODS: Eight pharmacies participated in the project: a capillary specimen collected by the pharmacist and, simultaneously, a lithium-heparin sample drawn by a physician of laboratory medicine for the pharmacy customers (n=106) were analyzed in the pharmacy and in the laboratory, respectively. Glucose, cholesterol, HDL-cholesterol, triglycerides, creatinine, uric acid, aspartate aminotransferase, alanine aminotransferase, were measured using: Reflotron, n=5; Samsung, n=1; Cardiocheck PA, n=1; Cholestech LDX, n=1 and Cobas 8000...
May 19, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27143482/long-term-effects-of-physical-activity-level-on-changes-in-healthy-body-mass-index-over-12-years-in-young-adult-women
#14
Toby G Pavey, G M E E Geeske Peeters, Sjaan R Gomersall, Wendy J Brown
OBJECTIVES: To examine the effects of overall level and timing of physical activity (PA) on changes from a healthy body mass index (BMI) category over 12 years in young adult women. PATIENTS AND METHODS: Participants in the Australian Longitudinal Study on Women's Health (younger cohort, born 1973-1978) completed surveys between 2000 (age 22-27 years) and 2012 (age 34-39 years). Physical activity was measured in 2000, 2003, 2006, and 2009 and was categorized as very low, low, active, or very active at each survey, and a cumulative PA score for this 9-year period was created...
June 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/26936041/measurement-of-pulmonary-artery-to-aorta-ratio-in-computed-tomography-is-correlated-with-pulmonary-artery-pressure-in-critically-ill-chronic-obstructive-pulmonary-disease-patients
#15
Ebru Ortaç Ersoy, Mine Durusu Tanriover, Serpil Öcal, Meltem Gulsun Akpinar, Arzu Topeli
AIM: Chronic obstructive pulmonary disease (COPD) is one of the leading chronic diseases and a common cause of death. Identification of COPD patients at high risk for complications and mortality is of utmost importance. Computed tomography (CT) can be used to measure the ratio of the diameter of the pulmonary artery (PA) to the diameter of the aorta (A), and PA/A ratio was shown to be correlated with PA pressure (PAP). However, the prognostic value of PA size remains unclear in patients with COPD...
June 2016: Journal of Critical Care
https://www.readbyqxmd.com/read/26923067/the-wild-wild-west-a-framework-to-integrate-mhealth-software-applications-and-wearables-to-support-physical-activity-assessment-counseling-and-interventions-for-cardiovascular-disease-risk-reduction
#16
REVIEW
Felipe Lobelo, Heval M Kelli, Sheri Chernetsky Tejedor, Michael Pratt, Michael V McConnell, Seth S Martin, Gregory J Welk
Physical activity (PA) interventions constitute a critical component of cardiovascular disease (CVD) risk reduction programs. Objective mobile health (mHealth) software applications (apps) and wearable activity monitors (WAMs) can advance both assessment and integration of PA counseling in clinical settings and support community-based PA interventions. The use of mHealth technology for CVD risk reduction is promising, but integration into routine clinical care and population health management has proven challenging...
May 2016: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/26899454/recommendations-for-utilization-of-the-paracorporeal-lung-assist-device-in-neonates-and-young-children-with-pulmonary-hypertension
#17
Avihu Z Gazit, Stuart C Sweet, R Mark Grady, Umar S Boston, Charles B Huddleston, David M Hoganson, Mark Shepard, Steve Raithel, Mary Mehegan, Allan Doctor, Philip C Spinella, Pirooz Eghtesady
The management of decompensating critically ill children with severe PH is extremely challenging and requires a multidisciplinary approach. Unfortunately, even with optimal care, these children might continue to deteriorate and develop inadequate systemic perfusion and at times cardiac arrest secondary to a pulmonary hypertensive crisis. Tools to support these children are limited, and at times, the team should proceed with offering extracorporeal support, especially in newly diagnosed patients who have not benefitted from medical therapy prior to their acute deterioration, in patients with severe pulmonary venous disease and in patients with alveolar capillary dysplasia...
March 2016: Pediatric Transplantation
https://www.readbyqxmd.com/read/26823732/epistaxis-and-pituitary-apoplexy-due-to-ruptured-internal-carotid-artery-aneurysm-embedded-within-pituitary-adenoma
#18
REVIEW
Zesheng Peng, Daofeng Tian, Hongliu Wang, Derek Kai Kong, Shenqi Zhang, Baohui Liu, Gang Deng, Zhou Xu, Liquan Wu, Baowei Ji, Long Wang, Qiang Cai, Mingchang Li, Junmin Wang, Aimin Zhang, Qianxue Chen
Epistaxis due to ruptured internal carotid artery (ICA) aneurysm embedded within a pituitary adenoma (PA) has seldom been reported in the literature. Here we want to elaborate the incidence, mechanisms, clinical manifestations, and treatment strategy for this condition. The first survived case of a patient with epistaxis and pituitary apoplexy due to ruptured aneurysm embedded within PA was reported and the literature was reviewed. A 53-year-old male patient presented to our institution with sudden onset epistaxis and progressive vision loss...
2015: International Journal of Clinical and Experimental Pathology
https://www.readbyqxmd.com/read/26737426/physical-activity-classification-meets-daily-life-review-on-existing-methodologies-and-open-challenges
#19
REVIEW
Muhammad Awais, Sabato Mellone, Lorenzo Chiari
Recent advances in the MEMS devices make it happen to wirelessly integrate miniature motion capturing devices with Smartphones and to use them in personal health care and physical activity monitoring in daily life. There is no ground truth, though, to measure the physical activity (PA) in daily life and because of this, there is no common validation procedure adapted by the researchers for benchmarking the performance of algorithms for PA classification. The major issue in the existing studies for PA classification is the utilization of structured protocol in a controlled setting or simulated daily environment, which limits their implementation in real life conditions where activities are unplanned and unstructured, both in occurrence and in duration...
2015: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/26563246/critical-features-of-peer-assessment-of-clinical-performance-to-enhance-adherence-to-a-low-back-pain-guideline-for-physical-therapists-a-mixed-methods-design
#20
RANDOMIZED CONTROLLED TRIAL
Marjo J M Maas, Simone A van Dulmen, Margaretha H Sagasser, Yvonne F Heerkens, Cees P M van der Vleuten, Maria W G Nijhuis-van der Sanden, Philip J van der Wees
BACKGROUND: Clinical practice guidelines are intended to improve the process and outcomes of patient care. However, their implementation remains a challenge. We designed an implementation strategy, based on peer assessment (PA) focusing on barriers to change in physical therapy care. A previously published randomized controlled trial showed that PA was more effective than the usual strategy "case discussion" in improving adherence to a low back pain guideline. Peer assessment aims to enhance knowledge, communication, and hands-on clinical skills consistent with guideline recommendations...
2015: BMC Medical Education
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