Akshatha N Srinivas, Diwakar Suresh, Deepak Suvarna, Pankaj Pathak, Suresh Giri, Suman, Suchitha Satish, Saravana Babu Chidambaram, Divya P Kumar
The pathophysiology of nonalcoholic steatohepatitis (NASH) is complex, owing to its diverse pathological drivers and, until recently, there were no approved drugs for this disease. Tecomella is a popular herbal medicine used to treat hepatosplenomegaly, hepatitis, and obesity. However, the potential role of Tecomella undulata in NASH has not yet been scientifically investigated. The administration of Tecomella undulata via oral gavage lowered body weight, insulin resistance, alanine transaminase (ALT), aspartate transaminase (AST), triglycerides, and total cholesterol in western diet sugar water (WDSW) fed mice but had no effect on chow diet normal water (CDNW) fed mice...
February 7, 2023: International Journal of Molecular Sciences