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Engy Shokry, Anselmo Elcana de Oliveira, Melissa Ameloti Gomes Avelino, Mariana Moreira de Deus, Nelson Roberto Antoniosi Filho
This work combines the advantages of volatile metabolites profiling as a young growing research field with a non-invasive sampling technique using earwax "a neglected body secretion" for detection and monitoring of biomarkers for diabetes mellitus (types 1 and 2). Earwax samples were collected from 26 diabetic patients of both types, analyzed by headspace gas chromatography mass spectrometry and confronted to the volatile earwax composition of 33 healthy individuals. Data mining analysis was conducted using different models to discriminate the healthy individuals from the diabetic patients and to discriminate between both types of diabetes as well...
March 9, 2017: Journal of Proteomics
Helene J Krouse, Anthony E Magit, Sarah O'Connor, Seth R Schwarz, Sandra A Walsh
This plain language summary serves as an overview in explaining earwax (cerumen). The summary applies to patients older than 6 months with a clinical diagnosis of earwax impaction and is based on the 2017 update of the Clinical Practice Guideline: Earwax (Cerumen Impaction). The evidence-based guideline includes research that supports diagnosis and treatment of earwax impaction. The guideline was developed to improve care by health care providers for managing earwax impaction by creating clear recommendations to use in medical practice...
January 2017: Otolaryngology—Head and Neck Surgery
Seth R Schwartz, Anthony E Magit, Richard M Rosenfeld, Bopanna B Ballachanda, Jesse M Hackell, Helene J Krouse, Claire M Lawlor, Kenneth Lin, Kourosh Parham, David R Stutz, Sandy Walsh, Erika A Woodson, Ken Yanagisawa, Eugene R Cunningham
The American Academy of Otolaryngology-Head and Neck Surgery Foundation (AAO-HNSF) has published a supplement to this issue of Otolaryngology-Head and Neck Surgery featuring the updated Clinical Practice Guideline: Earwax (Cerumen Impaction). To assist in implementing the guideline recommendations, this article summarizes the rationale, purpose, and key action statements. The 11 recommendations emphasize proper ear hygiene, diagnosis of cerumen impaction, factors that modify management, evaluating the need for intervention, and proper treatment...
January 2017: Otolaryngology—Head and Neck Surgery
Katya Polena Feder, David Michaud, James McNamee, Elizabeth Fitzpatrick, Pamela Ramage-Morin, Yves Beauregard
OBJECTIVES: There are no nationally representative hearing loss (HL) prevalence data available for Canadian youth using direct measurements. The present study objectives were to estimate national prevalence of HL using audiometric pure-tone thresholds (0.5 to 8 kHz) and or distortion product otoacoustic emissions (DPOAEs) for children and adolescents, aged 3 to 19 years. DESIGN: This cross-sectional population-based study presents findings from the 2012/2013 Canadian Health Measures Survey, entailing an in-person household interview and hearing measurements conducted in a mobile examination clinic...
January 2017: Ear and Hearing
Paola Marchisio, Carlotta Pipolo, Massimo Landi, Dario Consonni, Nicola Mansi, Giuseppe Di Mauro, Elisabetta Salvatici, Pasquale Di Pietro, Susanna Esposito, Giovanni Felisati, Nicola Principi
OBJECTIVES: Under physiological conditions, cerumen (Ce) is regularly extruded from the ear canal by a self-cleaning mechanism. Failure of this mechanism leads to excessive accumulation or impaction of Ce. Limited data are available concerning the prevalence of cerumen in healthy and sick infants and children. We assessed the prevalence of Ce in a large population of infants and children and compared the Ce removal attitudes of paediatricians (PEDs) and otorhinolaryngologists (ENTs). METHODS: Children seen in November 2014 for acute respiratory infections, including suspected acute otitis media, or well-being visits, were enrolled...
August 2016: International Journal of Pediatric Otorhinolaryngology
Saiko Sugiura, Sayaka Takeuchi, Mami Hisada, Chieko Sumigaki, Yasue Uchida, Tsutomu Nakashima, Kenji Toba
No abstract text is available yet for this article.
2016: Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
Ali Shidfar, Jun Wang, Elliot Wiesenfeld, Wei Zhang, Denise Scholtens, Angela Fought, Robert T Chatterton, Seema A Khan
PURPOSE: Nipple aspiration fluid (NAF) is a non-invasively-acquired biosample that can provide a window into the breast environment, but NAF yield is highly variable. Its determinants must be better understood for studies of breast cancer risk. The wet earwax phenotype was identified as one determinant of NAF yield in the 1970s, and is linked to single nucleotide polymorphisms (SNPs) in the ATP-binding cassette transporter gene ABCC11. We have investigated this, as well as SNPs in the prolactin (PRL) and prolactin receptor (PRLR) genes, in relation to NAF yield...
August 2016: Annals of Surgical Oncology
Miklós Kaán
Use of matierials of animal or human origin in dentistry (and generally in medicine) these days is regarded as an unusal way of intervention. However in earlier times, different tissues, parts, products and organs of animals were frequently used in healing. Some of these methods were rooted in magical thinking. As analogical treatments--based on similarity or analogy--e.g. powder of horn or teeth of pike was used for the treatment of decayed teeth and different worms, maggots, veenies were applied against "toothworm"...
2015: Orvostörténeti Közlemények
Tomoshi Tsuchiya, Junichi Arai, Keitaro Matsumoto, Takuro Miyazaki, Sumihisa Honda, Tsutomu Tagawa, Akihiro Nakamura, Hideki Taniguchi, Isao Sano, Shinji Akamine, Masashi Muraoka, Hiroshi Hisano, Naoya Yamasaki, Takeshi Nagayasu
BACKGROUND: Postoperative 1-year administration of S-1, an oral derivative of 5-fluorouracil (5-FU), was shown to be feasible in lung cancer. The 5-year survival rates of postoperative patients treated with S-1 adjuvant chemotherapy and the prognostic impact of clinicopathological factors were examined. METHODS: The data of 50 patients with curatively resected pathological stage IB to IIIA non-small cell lung cancer, who were treated with S-1 postoperatively, were analyzed...
2016: Chemotherapy
Raminta Daniulaityte, Ramzi W Nahhas, Sanjaya Wijeratne, Robert G Carlson, Francois R Lamy, Silvia S Martins, Edward W Boyer, G Alan Smith, Amit Sheth
AIMS: Media reports suggest increasing popularity of marijuana concentrates ("dabs"; "earwax"; "budder"; "shatter; "butane hash oil") that are typically vaporized and inhaled via a bong, vaporizer or electronic cigarette. However, data on the epidemiology of marijuana concentrate use remain limited. This study aims to explore Twitter data on marijuana concentrate use in the U.S. and identify differences across regions of the country with varying cannabis legalization policies. METHODS: Tweets were collected between October 20 and December 20, 2014, using Twitter's streaming API...
October 1, 2015: Drug and Alcohol Dependence
Jacob Urkin, Yair Bar-David, Yehuda Holdstein
No abstract text is available yet for this article.
December 2015: Clinical Pediatrics
R Arlanov, T Lang, G Jedlitschky, E Schaeffeler, T Ishikawa, M Schwab, A T Nies
Multidrug resistance protein 8 (ABCC11) is an efflux transporter for anionic lipophilic compounds, conferring resistance to antiviral and anticancer agents like 5-fluorouracil (5-FU). ABCC11 missense variants may contribute to variability in drug response but functional consequences, except for the 'earwax variant' c.538G>A, are unknown. Using the 'Screen and Insert' technology, we generated human embryonic kidney 293 cells stably expressing ABCC11 missense variants frequently occurring in different ethnic populations: c...
April 2016: Pharmacogenomics Journal
Waheed Atilade Adegbiji, Biodun Sulyman Alabi, Oyebanji Anthony Olajuyin, C C Nwawolo
BACKGROUND AND AIM: Earwax impaction is a common ear disorder with presentation worldwide. This study aimed at determining the clinical presentation, patients' perception of earwax, and its predisposing factors among Nigerians. MATERIALS AND METHODS: This prospective study was conducted on consented patients with diagnosis of earwax impaction at the Ear, Nose, and Throat Clinic of the University Teaching Hospital, Ado Ekiti, Ekiti state, south west, Nigeria. The research was carried out over a period of one year (April 2008 and March 2009)...
October 2014: Journal of Family Medicine and Primary Care
T Browne, R Fourie
Although cerumen management (CM) is routinely performed by audiologists in some countries, this is currently not the case in the Republic of Ireland. This study involved surveying the opinions of Audiologists and Ear Nose and Throat specialists (ENTs) in relation to audiologists conducting CM. In total, 20 ENT Consultants (29%) and 51 audiologists (64%) in the public services responded to an online survey. There was agreement that CM should be within audiologists' remit. However, with regard to risk, opinions were significantly different, with 15 ENTs (75%), compared to 14 audiologists (27%), in agreement that CM management by audiologists was more risky to patients...
November 2014: Irish Medical Journal
Katharine A Prokop-Prigge, Corrine J Mansfield, M Rockwell Parker, Erica Thaler, Elizabeth A Grice, Charles J Wysocki, George Preti
This report describes the volatile organic compounds (VOCs) associated with human cerumen (earwax) and the effects of ethnicity/race and variation on the ATP-binding cassette, sub-family C, member 11 gene (ABCC11). A single nucleotide polymorphism (SNP) in ABCC11 affects the cerumen VOC profiles of individuals from African, Caucasian, and Asian descent. Employing gas chromatography/mass spectrometry (GC/MS) we have identified the nature and relative abundance of cerumen VOCs from 32 male donors. Our results show that cerumen contains a complex mixture of VOCs and that the amounts of these compounds vary across individuals as well as across ethnic/racial groups...
January 2015: Journal of Chemical Ecology
Alison M Eychner, Roberta J Lebo, Kelly M Elkins
We compared four proteases in the QIAamp DNA Investigator Kit (Qiagen) to extract DNA for use in multiplex polymerase chain reaction (PCR) assays. The aim was to evaluate alternate proteases for improved DNA recovery as compared with proteinase K for forensic, biochemical research, genetic paternity and immigration, and molecular diagnostic purposes. The Quantifiler Kit TaqMan quantitative PCR assay was used to measure the recovery of DNA from human blood, semen, buccal cells, breastmilk, and earwax in addition to low-template samples, including diluted samples, computer keyboard swabs, chewing gum, and cigarette butts...
June 1, 2015: Analytical Biochemistry
Gro Gade Haanes, Marit Kirkevold, Gunnar Horgen, Dag Hofoss, Grethe Eilertsen
BACKGROUND: Hearing and vision impairments increase with age and are common risk factors for functional decline reduced social participation and withdrawal. OBJECTIVE: Describe the hearing and vision of home care patients older than 80 years. METHODS: Ninety-three older adults (80+ years) receiving home care were screened for hearing and vision in their homes. Data were collected using a HEINE Mini 3000(®) Otoscope to examine the eardrum and presence of earwax, an Entomed SA201-IV portable pure-tone audiometer to measure the pure-tone average (PTAV), a logarithm of the minimum angle of resolution chart to measure visual acuity (VA), and the Combined Serious Sensory Impairment interview guide...
2014: Journal of Multidisciplinary Healthcare
Takeshi Kusunoki, Katsuhisa Ikeda, Mie Miyashita
Extracranial meningioma with extension into a middle ear is very uncommon. A 74-year-old female was admitted to our hospital with right ear bleeding when removing earwax. In this case, magnetic resonance imaging, computed tomography, her past history and operative findings would consider as infiltrative growth from the right sphenoid ridge meningioma to the right middle ear via the right petrous pyramid and bilateral optic nerve. She underwent only partial extirpation with decompression for optic nerve, rather than total extirpation including middle ear and temporal bone, due to wide invasion of the middle cranial fossa and caversinus sinus...
May 29, 2012: Clinics and Practice
(no author information available yet)
No abstract text is available yet for this article.
March 2014: Mayo Clinic Health Letter
Kaoru Hamada, Sanehito Haruyama, Takashi Yamaguchi, Kayo Yamamoto, Kana Hiromasa, Manabu Yoshioka, Daisuke Nishio, Motonobu Nakamura
Human body odour and earwax type are genetically dependent on a single-nucleotide polymorphism (SNP) located in the ABCC11 gene. So far, it still remains to be clear how SNP in the ABCC11 gene is associated with human malodour. In a recent issue of Experimental Dermatology, Baumann et al. propose one of the underlying molecular pathways. Although one of the amino acid conjugated of the odorants, Cys-Gly-3-methyl-3-sulfanylhexanol (3M3SH), was not taken up by the transporter ABCC11, glutathione conjugate of 3MSH (SG-3MSH) was transported by ABCC11...
May 2014: Experimental Dermatology
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