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https://www.readbyqxmd.com/read/28912899/earwax-as-an-alternative-specimen-for-forensic-analysis
#1
Engy Shokry, Jair Gonzalez Marques, Paulo César Ragazzo, Naiara Zedes Pereira, Nelson Roberto Antoniosi Filho
In this work, we presented, for the first time, earwax as an alternative forensic specimen for detecting 12 neuropsychotic drugs employing liquid chromatography-tandem mass spectrometry in positive and negative ion modes after straightforward extraction with methanol. The method was validated and standard curves were established by external calibration with correlation coefficients >0.99. All precision, accuracy, matrix effects, extraction recoveries, and carryover were within acceptable limits; limits of quantification were sufficiently low to quantify almost all the samples tested...
2017: Forensic Toxicology
https://www.readbyqxmd.com/read/28866875/substance-p-and-calcitonin-gene-related-peptide-in-the-glands-of-external-auditory-canal-skin
#2
Yong Joo Yoon, Jin Yoon, Eun Jung Lee, Jong Seung Kim
Objectives.: The earwax (cerumen) that covers external auditory canal (EAC) skin contains a mixture of ceruminous and sebaceous gland substances, such as lipids, peptides, and proteins. The components secreted from the ceruminous gland that is a modified sweat gland form cerumen and contain several antimicrobial factors. Since substance P (SP) and calcitonin gene-related peptide (CGRP), known as a secretagogue, have been found in sweat glands, our purpose was to determine the expression of SP and CGRP in the glands of EAC skin...
September 5, 2017: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/28841695/earwax-metabolomics-an-innovative-pilot-metabolic-profiling-study-for-assessing-metabolic-changes-in-ewes-during-periparturition-period
#3
Engy Shokry, Julião Pereira, Jair Gonzalez Marques Júnior, Paulo Henrique Jorge da Cunha, Antônio Dionísio Feitosa Noronha Filho, Jessica Alves da Silva, Maria Clorinda Soares Fioravanti, Anselmo Elcana de Oliveira, Nelson Roberto Antoniosi Filho
Important metabolic changes occur during transition period of late pregnancy and early lactation to meet increasing energy demands of the growing fetus and for milk production. The aim of this investigation is to present an innovative and non-invasive tool using ewe earwax sample analysis to assess the metabolic profile in ewes during late pregnancy and early lactation. In this work, earwax samples were collected from 28 healthy Brazilian Santa Inês ewes divided into 3 sub-groups: 9 non-pregnant ewes, 6 pregnant ewes in the last 30 days of gestation, and 13 lactating ewes ≤ 30 days postpartum...
2017: PloS One
https://www.readbyqxmd.com/read/28716647/earwax-a-clue-to-discover-fluoroacetate-intoxication-in-cattle
#4
Engy Shokry, Fabrício Carrião Dos Santos, Paulo Henrique Jorge da Cunha, Maria Clorinda Soares Fioravanti, Antônio Dionísio Feitosa Noronha Filho, Naiara Zedes Pereira, Nelson Roberto Antoniosi Filho
An innovative method was developed to detect fluoroacetate poisoning in cattle by headspace/gas chromatographic analysis of earwax samples of intoxicated cattle. Samples were collected from 2 groups of cattle subjected to induced fluoroacetate intoxication, each group receiving a different dose of acetamide (antidote). Monofluoroacetic acid was detected in samples of intoxicated cattle in concentrations inversely proportional to the dose of acetamide. Thus, earwax analysis represents a successful approach for detection and monitoring of fluoroacetate poisoning...
July 15, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28485377/a-missense-variant-of-the-abcc11-gene-is-associated-with-axillary-osmidrosis-susceptibility-and-clinical-phenotypes-in-the-chinese-han-population
#5
Yunqing Ren, Wenting Liu, Jisu Chen, Jianyou Wang, Ke Wang, Jiong Zhou, Suiqing Cai, Min Zheng, Jianjun Liu, Lunfei Liu, Dan Xue
Axillary osmidrosis (AO) is a common condition characterized by an offensive odor arising from apocrine gland secretions in the axillae that socially and psychologically impairs affected individuals. The exact aetiology of AO is still not fully understood, but genetic factors have been suggested to play an important role. Recently, a single nucleotide polymorphism (SNP) rs17822931 in the ABCC11 gene located on human chromosome 16q12.1 has been shown to be associated with AO. In this study, we genotyped rs17822931 in two independent samples of Chinese Hans including 93 AO individuals vs 95 controls and 81 AO individuals vs 106 controls by using SNaPshot Multiplex Kit...
May 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28286320/earwax-a-neglected-body-secretion-or-a-step-ahead-in-clinical-diagnosis-a-pilot-study
#6
Engy Shokry, Anselmo Elcana de Oliveira, Melissa Ameloti Gomes Avelino, Mariana Moreira de Deus, Nelson Roberto Antoniosi Filho
This work combines the advantages of volatile metabolites profiling as a young growing research field with a non-invasive sampling technique using earwax "a neglected body secretion" for detection and monitoring of biomarkers for diabetes mellitus (types 1 and 2). Earwax samples were collected from 26 diabetic patients of both types, analyzed by headspace gas chromatography mass spectrometry and confronted to the volatile earwax composition of 33 healthy individuals. Data mining analysis was conducted using different models to discriminate the healthy individuals from the diabetic patients and to discriminate between both types of diabetes as well...
March 9, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28045640/plain-language-summary-earwax-cerumen-impaction
#7
Helene J Krouse, Anthony E Magit, Sarah O'Connor, Seth R Schwarz, Sandra A Walsh
This plain language summary serves as an overview in explaining earwax (cerumen). The summary applies to patients older than 6 months with a clinical diagnosis of earwax impaction and is based on the 2017 update of the Clinical Practice Guideline: Earwax (Cerumen Impaction). The evidence-based guideline includes research that supports diagnosis and treatment of earwax impaction. The guideline was developed to improve care by health care providers for managing earwax impaction by creating clear recommendations to use in medical practice...
January 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28045632/clinical-practice-guideline-update-earwax-cerumen-impaction-executive-summary
#8
Seth R Schwartz, Anthony E Magit, Richard M Rosenfeld, Bopanna B Ballachanda, Jesse M Hackell, Helene J Krouse, Claire M Lawlor, Kenneth Lin, Kourosh Parham, David R Stutz, Sandy Walsh, Erika A Woodson, Ken Yanagisawa, Eugene R Cunningham
The American Academy of Otolaryngology-Head and Neck Surgery Foundation (AAO-HNSF) has published a supplement to this issue of Otolaryngology-Head and Neck Surgery featuring the updated Clinical Practice Guideline: Earwax (Cerumen Impaction). To assist in implementing the guideline recommendations, this article summarizes the rationale, purpose, and key action statements. The 11 recommendations emphasize proper ear hygiene, diagnosis of cerumen impaction, factors that modify management, evaluating the need for intervention, and proper treatment...
January 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/27556530/prevalence-of-hearing-loss-among-a-representative-sample-of-canadian-children-and-adolescents-3-to-19-years-of-age
#9
Katya Polena Feder, David Michaud, James McNamee, Elizabeth Fitzpatrick, Pamela Ramage-Morin, Yves Beauregard
OBJECTIVES: There are no nationally representative hearing loss (HL) prevalence data available for Canadian youth using direct measurements. The present study objectives were to estimate national prevalence of HL using audiometric pure-tone thresholds (0.5 to 8 kHz) and or distortion product otoacoustic emissions (DPOAEs) for children and adolescents, aged 3 to 19 years. DESIGN: This cross-sectional population-based study presents findings from the 2012/2013 Canadian Health Measures Survey, entailing an in-person household interview and hearing measurements conducted in a mobile examination clinic...
January 2017: Ear and Hearing
https://www.readbyqxmd.com/read/27368443/cerumen-a-fundamental-but-neglected-problem-by-pediatricians
#10
Paola Marchisio, Carlotta Pipolo, Massimo Landi, Dario Consonni, Nicola Mansi, Giuseppe Di Mauro, Elisabetta Salvatici, Pasquale Di Pietro, Susanna Esposito, Giovanni Felisati, Nicola Principi
OBJECTIVES: Under physiological conditions, cerumen (Ce) is regularly extruded from the ear canal by a self-cleaning mechanism. Failure of this mechanism leads to excessive accumulation or impaction of Ce. Limited data are available concerning the prevalence of cerumen in healthy and sick infants and children. We assessed the prevalence of Ce in a large population of infants and children and compared the Ce removal attitudes of paediatricians (PEDs) and otorhinolaryngologists (ENTs). METHODS: Children seen in November 2014 for acute respiratory infections, including suspected acute otitis media, or well-being visits, were enrolled...
August 2016: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/27250224/the-safety-and-effectiveness-of-earwax-removal-by-nurse-in-cognitive-impaired-inpatients
#11
Saiko Sugiura, Sayaka Takeuchi, Mami Hisada, Chieko Sumigaki, Yasue Uchida, Tsutomu Nakashima, Kenji Toba
No abstract text is available yet for this article.
2016: Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
https://www.readbyqxmd.com/read/27027309/genetic-determinants-of-nipple-aspiration-fluid-yield
#12
Ali Shidfar, Jun Wang, Elliot Wiesenfeld, Wei Zhang, Denise Scholtens, Angela Fought, Robert T Chatterton, Seema A Khan
PURPOSE: Nipple aspiration fluid (NAF) is a non-invasively-acquired biosample that can provide a window into the breast environment, but NAF yield is highly variable. Its determinants must be better understood for studies of breast cancer risk. The wet earwax phenotype was identified as one determinant of NAF yield in the 1970s, and is linked to single nucleotide polymorphisms (SNPs) in the ATP-binding cassette transporter gene ABCC11. We have investigated this, as well as SNPs in the prolactin (PRL) and prolactin receptor (PRLR) genes, in relation to NAF yield...
August 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/26875294/-healing-dental-and-oral-problems-by-remedies-of-animal-and-of-human-origin
#13
Miklós Kaán
Use of matierials of animal or human origin in dentistry (and generally in medicine) these days is regarded as an unusal way of intervention. However in earlier times, different tissues, parts, products and organs of animals were frequently used in healing. Some of these methods were rooted in magical thinking. As analogical treatments--based on similarity or analogy--e.g. powder of horn or teeth of pike was used for the treatment of decayed teeth and different worms, maggots, veenies were applied against "toothworm"...
2015: Orvostörténeti Közlemények
https://www.readbyqxmd.com/read/26606244/prognostic-impact-of-the-abcc11-mrp8-polymorphism-in-adjuvant-oral-chemotherapy-with-s-1-for-non-small-cell-lung-cancer
#14
MULTICENTER STUDY
Tomoshi Tsuchiya, Junichi Arai, Keitaro Matsumoto, Takuro Miyazaki, Sumihisa Honda, Tsutomu Tagawa, Akihiro Nakamura, Hideki Taniguchi, Isao Sano, Shinji Akamine, Masashi Muraoka, Hiroshi Hisano, Naoya Yamasaki, Takeshi Nagayasu
BACKGROUND: Postoperative 1-year administration of S-1, an oral derivative of 5-fluorouracil (5-FU), was shown to be feasible in lung cancer. The 5-year survival rates of postoperative patients treated with S-1 adjuvant chemotherapy and the prognostic impact of clinicopathological factors were examined. METHODS: The data of 50 patients with curatively resected pathological stage IB to IIIA non-small cell lung cancer, who were treated with S-1 postoperatively, were analyzed...
2016: Chemotherapy
https://www.readbyqxmd.com/read/26338481/-time-for-dabs-analyzing-twitter-data-on-marijuana-concentrates-across-the-u-s
#15
Raminta Daniulaityte, Ramzi W Nahhas, Sanjaya Wijeratne, Robert G Carlson, Francois R Lamy, Silvia S Martins, Edward W Boyer, G Alan Smith, Amit Sheth
AIMS: Media reports suggest increasing popularity of marijuana concentrates ("dabs"; "earwax"; "budder"; "shatter; "butane hash oil") that are typically vaporized and inhaled via a bong, vaporizer or electronic cigarette. However, data on the epidemiology of marijuana concentrate use remain limited. This study aims to explore Twitter data on marijuana concentrate use in the U.S. and identify differences across regions of the country with varying cannabis legalization policies. METHODS: Tweets were collected between October 20 and December 20, 2014, using Twitter's streaming API...
October 1, 2015: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/26156979/cleaning-earwax-impaction-clinical-tips-for-the-primary-care-clinician
#16
Jacob Urkin, Yair Bar-David, Yehuda Holdstein
No abstract text is available yet for this article.
December 2015: Clinical Pediatrics
https://www.readbyqxmd.com/read/25896536/functional-characterization-of-common-protein-variants-in-the-efflux-transporter-abcc11-and-identification-of-t546m-as-functionally-damaging-variant
#17
R Arlanov, T Lang, G Jedlitschky, E Schaeffeler, T Ishikawa, M Schwab, A T Nies
Multidrug resistance protein 8 (ABCC11) is an efflux transporter for anionic lipophilic compounds, conferring resistance to antiviral and anticancer agents like 5-fluorouracil (5-FU). ABCC11 missense variants may contribute to variability in drug response but functional consequences, except for the 'earwax variant' c.538G>A, are unknown. Using the 'Screen and Insert' technology, we generated human embryonic kidney 293 cells stably expressing ABCC11 missense variants frequently occurring in different ethnic populations: c...
April 2016: Pharmacogenomics Journal
https://www.readbyqxmd.com/read/25657947/earwax-impaction-symptoms-predisposing-factors-and-perception-among-nigerians
#18
Waheed Atilade Adegbiji, Biodun Sulyman Alabi, Oyebanji Anthony Olajuyin, C C Nwawolo
BACKGROUND AND AIM: Earwax impaction is a common ear disorder with presentation worldwide. This study aimed at determining the clinical presentation, patients' perception of earwax, and its predisposing factors among Nigerians. MATERIALS AND METHODS: This prospective study was conducted on consented patients with diagnosis of earwax impaction at the Ear, Nose, and Throat Clinic of the University Teaching Hospital, Ado Ekiti, Ekiti state, south west, Nigeria. The research was carried out over a period of one year (April 2008 and March 2009)...
October 2014: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/25556257/the-feasibility-of-audiologists-removing-earwax
#19
REVIEW
T Browne, R Fourie
Although cerumen management (CM) is routinely performed by audiologists in some countries, this is currently not the case in the Republic of Ireland. This study involved surveying the opinions of Audiologists and Ear Nose and Throat specialists (ENTs) in relation to audiologists conducting CM. In total, 20 ENT Consultants (29%) and 51 audiologists (64%) in the public services responded to an online survey. There was agreement that CM should be within audiologists' remit. However, with regard to risk, opinions were significantly different, with 15 ENTs (75%), compared to 14 audiologists (27%), in agreement that CM management by audiologists was more risky to patients...
November 2014: Irish Medical Journal
https://www.readbyqxmd.com/read/25501636/ethnic-racial-and-genetic-influences-on-cerumen-odorant-profiles
#20
Katharine A Prokop-Prigge, Corrine J Mansfield, M Rockwell Parker, Erica Thaler, Elizabeth A Grice, Charles J Wysocki, George Preti
This report describes the volatile organic compounds (VOCs) associated with human cerumen (earwax) and the effects of ethnicity/race and variation on the ATP-binding cassette, sub-family C, member 11 gene (ABCC11). A single nucleotide polymorphism (SNP) in ABCC11 affects the cerumen VOC profiles of individuals from African, Caucasian, and Asian descent. Employing gas chromatography/mass spectrometry (GC/MS) we have identified the nature and relative abundance of cerumen VOCs from 32 male donors. Our results show that cerumen contains a complex mixture of VOCs and that the amounts of these compounds vary across individuals as well as across ethnic/racial groups...
January 2015: Journal of Chemical Ecology
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