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https://www.readbyqxmd.com/read/28102922/effect-of-the-unfilled-space-size-of-the-abutment-screw-access-hole-on-the-extruded-excess-cement-and-retention-of-single-implant-zirconia-crowns
#1
Sulieman S Al-Johany, Mohammad D Al Amri, Ahmed S Al-Bakri, Mohammed N Al-Qarni
PURPOSE: To evaluate in vitro the effect of the size of the unfilled space of the abutment screw access hole on the amount of extruded excess cement and the retention of zirconia copings. MATERIALS AND METHODS: Twelve dental implant replicas were attached to the corresponding abutments and embedded in acrylic resin blocks. A total of 36 CAD/CAM zirconia copings were fabricated by one technician using the standard technique. Abutments were divided into group I: the entire screw access channel was completely filled (nonspaced); group II: 1-mm-spaced; and group III: 2-mm-spaced...
January 19, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/28102532/time-to-epinephrine-in-out-of-hospital-cardiac-arrest-a-retrospective-analysis-of-intraosseous-versus-intravenous-access
#2
Elliot M Ross, Julian Mapp, Chetan Kharod, David A Wampler, Christopher Velasquez, David A Miramontes
INTRODUCTION: The 2015 advanced cardiac life support update continues to advocate administering epinephrine during cardiac arrest. The goal of our study is to determine if prehospital intraosseous (IO) access results in shorter time to epinephrine than prehospital peripheral intravenous (PIV) access. METHODS: The out-of-hospital cardiac arrest (OHCA) database of a large, urban, fire-based emergency medical services system was searched for consecutive cases of OHCA between January 2013 and December 2015...
April 2016: American Journal of Disaster Medicine
https://www.readbyqxmd.com/read/28101475/anticonvulsive-effects-of-licofelone-on-status-epilepticus-induced-by-lithium-pilocarpine-in-wistar-rats-a-role-for-inducible-nitric-oxide-synthase
#3
Seyyed Majid Eslami, Mohammad Mobin Moradi, Mehdi Ghasemi, Ahmad Reza Dehpour
BACKGROUND AND PURPOSE: Status epilepticus (SE) is a neurological disorder with high prevalence and mortality rates, requiring immediate intervention. Licofelone is a cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) inhibitor, which its effectiveness to treat osteoarthritis has been approved. Increasing evidence suggests an involvement of COX and LOX enzymes in epileptic disorders. Thus, in the present study we investigate possible effects of licofelone on prevention and termination of SE...
December 2016: Journal of Epilepsy Research
https://www.readbyqxmd.com/read/28101408/in-vivo-visualization-and-ex-vivo-quantification-of-experimental-myocardial-infarction-by-indocyanine-green-fluorescence-imaging
#4
Dmitry Sonin, Garry Papayan, Evgeniia Pochkaeva, Svetlana Chefu, Sarkis Minasian, Dmitry Kurapeev, Jarle Vaage, Nickolay Petrishchev, Michael Galagudza
The fluorophore indocyanine green accumulates in areas of ischemia-reperfusion injury due to an increase in vascular permeability and extravasation of the dye. The aim of the study was to validate an indocyanine green-based technique of in vivo visualization of myocardial infarction. A further aim was to quantify infarct size ex vivo and compare this technique with the standard triphenyltetrazolium chloride staining. Wistar rats were subjected to regional myocardial ischemia (30 minutes) followed by reperfusion (n = 7)...
January 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28100346/-impact-of-cd137-cd137l-signaling-mediated-exocytosis-of-autophagosome-within-vascular-smooth-muscle-cells-on-the-formation-of-atherosclerotic-calcification
#5
B Li, X Y Li, W Zhong, C Shao, Z Q Wang, W Yuan, J C Yan
Objective: To explore whether CD137-CD137L signaling mediated exocytosis of autophagosome within vascular smooth muscle cells (VSMCs) could influence the formation of atherosclerotic calcification. Methods: Fifteen 8-week-old male ApoE(-/-)(C57BL/6J-KO) mice fed with high fat diet for 5 weeks were randomly divided into three groups by using stochastic indicator method as follows: control group, n=5; agonist-CD137 group: agonist-CD137 antibody 200 μg/2 weeks for 4 weeks, ip, n=5; anti-CD137 group: 200 μg anti-CD137 antibody+ 200 μg agonist-CD137 antibody/2 weeks for 4 weeks, ip, n=5...
January 25, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/28100332/-expression-and-significance-of-mtor-4ebp1-hif-1%C3%AE-vegf-signaling-pathway-in-lung-tissues-of-asthmatic-mice
#6
Li Wang, Yan-Li Zhang, Xiu-Fang Wang, Zhe Song, Wei Wang
OBJECTIVE: To study the expression and significance of the mammalian target of rapamycin (mTOR)/eukaryote initiating factor 4E binding protein 1(4EBP1)/hypoxia inducible factor-1α (HIF-1α)/vascular endothelial growth factor (VEGF) signaling pathway in asthmatic mice. METHODS: Forty SPF level 6-8 week-old female Balb/C mice were randomly divided into control, asthma, budesonide and mTOR inhibitor (rapamycin) intervention groups (n=10 each). The asthmatic mouse model was prepared via OVA induction and challenge test...
January 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28099988/exercise-based-rehabilitation-programmes-for-pulmonary-hypertension
#7
REVIEW
Norman R Morris, Fiona D Kermeen, Anne E Holland
BACKGROUND: Individuals with pulmonary hypertension (PH) have reduced exercise capacity and quality of life. Despite initial concerns that exercise training may worsen symptoms in this group, several studies have reported improvements in functional capacity and well-being following exercise-based rehabilitation in PH. OBJECTIVES: To assess the efficacy and safety of exercise-based rehabilitation for people with PH. Primary outcomes were exercise capacity, adverse events during the intervention period and health-related quality of life (HRQoL)...
January 19, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28099979/milrinone-pharmacokinetics-and-pharmacodynamics-in-neonates-with-persistent-pulmonary-hypertension-of-the-newborn
#8
Annie Giaccone, Athena F Zuppa, Beena Sood, Meryl S Cohen, Michael L O'Byrne, Ganesh Moorthy, Amit Mathur, Haresh Kirpalani
Objective To describe the pharmacokinetics and pharmacodynamics of milrinone in infants with persistent pulmonary hypertension of the newborn (PPHN) and to explore the impact of age on milrinone disposition. Design Randomized, open label pilot study. Setting Multicenter; level 3 and level 4 neonatal intensive care units. Patients Six infants ≥34 weeks' gestational age and <10 days of life with persistent hypoxemia receiving inhaled nitric oxide. Intervention Intravenous milrinone lactate in one of two dosing regimens: (1) low dose, 20 mcg/kg bolus followed by 0...
January 18, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/28099700/a-systematic-review-and-meta-analysis-of-randomized-controlled-trials-comparing-hysteroscopic-morcellation-with-resectoscopy-for-patients-with-endometrial-lesions
#9
REVIEW
Chunbo Li, Zhiyuan Dai, Yuping Gong, Bingying Xie, Bei Wang
BACKGROUND: Results on the efficacy of hysteroscopic morcellation for patients with endometrial lesions remain conflicting. OBJECTIVES: To compare hysteroscopic morcellation with conventional resectoscopy for removal of endometrial lesions. SEARCH STRATEGY: Electronic databases were searched for reports published up to February 1, 2016, using terms such as "morcellator," "morcellators," "morcellate," "morcellation," "morcellated," "hysteroscopy," "hysteroscopy," "uteroscope," and "transcervical...
January 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28099698/safety-of-vaginal-delivery-among-dichorionic-diamniotic-twins-over-10%C3%A2-years-in-a-uk-teaching-hospital
#10
Ewelina Rzyska, Bini Ajay, Edwin Chandraharan
OBJECTIVE: To determine whether vaginal delivery among dichorionic diamniotic twins remains a safe option following full implementation of the European Working Time Directive in the UK. METHODS: A retrospective study was conducted using data for women with dichorionic diamniotic twin pregnancies who attended a teaching hospital in London, UK, for delivery between January 4, 2000, and December 23, 2010. RESULTS: Among 892 women, 474 (53.1%) attempted vaginal delivery, 220 (46...
January 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28099192/aerobic-exercise-training-in-very-severe-chronic-obstructive-pulmonary-disease-a-systematic-review-and-meta-analysis
#11
Mara Paneroni, Carla Simonelli, Michele Vitacca, Nicolino Ambrosino
OBJECTIVE: To evaluate the effectiveness of exercise training in patients with very severe chronic obstructive pulmonary disease (COPD). DESIGN: We searched MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and Cumulative Index to Nursing and Allied Health Literature databases using the following as search terms: COPD, Chronic Obstructive Pulmonary Disease, Exercise, and Pulmonary Rehabilitation. We included randomized controlled trials (RCTs) of subjects with forced expiratory volume in the first second of less than 35% of the predicted normal value enrolled in in-patient, outpatient, or home- or community-based training programs lasting at least 4 weeks with respect to usual care...
January 17, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28099175/two-for-one-a-case-report-of-intravenous-lipid-emulsion-to-treat-local-anesthetic-systemic-toxicity-in-term-pregnancy
#12
Jonathan Dun-Chi Lin, Eellan Sivanesan, Terese T Horlocker, Andres Missair
Combined spinal-epidural (CSE) analgesia is a frequently used method of labor analgesia. Although it is considered safe and effective, CSE can be complicated by local anesthetic systemic toxicity (LAST), a potentially life-threatening condition. We present a case of LAST that developed in a primigravida 50 minutes after uneventful placement of a CSE. Her symptoms resolved within 10 minutes of administering intralipid emulsion. She subsequently underwent cesarean delivery under spinal anesthesia for failure to progress without sequelae in the mother or infant...
January 17, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/28098726/assessment-of-retinal-blood-flow-in-diabetic-retinopathy-using-doppler-fourier-domain-optical-coherence-tomography
#13
Sowmya Srinivas, Ou Tan, Muneeswar G Nittala, Jennifer L Wu, Amani A Fazwi, David Huang, SriniVas R Sadda
PURPOSE: To evaluate retinal blood flow measurements in normal eyes and eyes with varying levels of diabetic retinopathy (DR) using Doppler Fourier-domain optical coherence tomography (FD-OCT). METHODS: Twenty-two eyes of 19 subjects, 10 with severe nonproliferative DR (NPDR) and 12 with proliferative DR (PDR), were compared with 44 eyes of 40 healthy control subjects. All eyes were scanned by RTvue FD-OCT. Color disk photographs and cube/volume scans of the optic nerve head were obtained...
January 16, 2017: Retina
https://www.readbyqxmd.com/read/28098718/double-exposure-to-adverse-psychosocial-work-factors-and-high-family-responsibilities-as-related-to-ambulatory-blood-pressure-at-work-a-5-year-prospective-study-in-women-with-white-collar-jobs
#14
Mahée Gilbert-Ouimet, Chantal Brisson, Alain Milot, Michel Vézina
OBJECTIVE: Accumulating evidence shows that psychosocial work factors of the demand-control and effort-reward imbalance models may contribute to increase blood pressure (BP). Women are more likely to be exposed to these psychosocial factors than men. Moreover, women spend twice as much time per week performing family responsibilities than men. This study aims to evaluate the longitudinal association of the double exposure to psychosocial work factors and high family responsibilities in women with BP over a 5-year follow-up...
January 17, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28098671/the-effects-of-effleurage-hand-massage-on-anxiety-and-pain-in-patients-undergoing-chemotherapy
#15
Monica E Gensic, Brandy R Smith, Dawn M LaBarbera
OBJECTIVE: To determine the effectiveness of effleurage hand massage performed by trained volunteers on reducing anxiety and pain in patients receiving treatment at a chemotherapy center in Fort Wayne, Ind., as measured by heart rate, respiratory rate, BP, visual analogue scale for anxiety (VAS-A), and visual analogue scale for pain (VAS-P). METHODS: Volunteers trained in effleurage massage gave 10-minute hand massages to 24 patients at the beginning of their chemotherapy session...
February 2017: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/28098395/first-uhplc-ms-ms-method-coupled-with-automated-on-line-spe-for-quantification-both-of-tacrolimus-and-everolimus-in-peripheral-blood-mononuclear-cells-and-its-application-on-samples-from-co-treated-pediatric-patients
#16
Debora Pensi, Amedeo De Nicolò, Michele Pinon, Clarissa Pisciotta, Pier Luigi Calvo, Antonello Nonnato, Renato Romagnoli, Francesco Tandoi, Giovanni Di Perri, Antonio D'Avolio
Tacrolimus (TAC, FK-506) and everolimus (EVE, RAD001) are immunosuppressors used to treat pediatric patients undergoing liver transplantation. Their hematic TDM by liquid chromatography became standard practice. However, it does not always reflect concentrations at their active site. Our aim was to develop and validate a new method for the simultaneous TAC and EVE quantification into target cells: Peripheral-Blood-Mononuclear-Cells (PBMCs). PBMCs were collected using Cell-Preparation-Tubes; cells number and MCV were evaluated by an automatic cell counter...
January 18, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28097812/monitoring-immune-response-after-allogeneic-transplantation-of-mesenchymal-stem-cells-for-osteochondral-repair
#17
Elhussein Elbadry Mahmoud, Tanaka Yuka, Naosuke Kamei, Yohei Harada, Hideki Ohdan, Adachi Nobuo, Mitsuo Ochi
The aim of this study was to investigate safety of using allogeneic magnetically labeled mesenchymal stem cells (m-MSCs) to ameliorate osteochondral repair as well as autologous one, with immune surveillance using a mixed lymphocyte reaction (MLR) assay. Twenty knees of Japanese white rabbits were randomly divided into two groups: the control (autologous) group, the transplantation of 2 × 10(5)  m-MSCs and the experimental (allogeneic) group, transplantation of 2 × 10(5)  m-MSCs from Dutch rabbit was performed, with exposure to an external magnetic device for 10 minutes, then rabbits were euthanized after 12 weeks...
January 17, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28097330/electroencephalographic-periodic-discharges-and-frequency-dependent-brain-tissue-hypoxia-in-acute-brain-injury
#18
Jens Witsch, Hans-Peter Frey, J Michael Schmidt, Angela Velazquez, Cristina M Falo, Michael Reznik, David Roh, Sachin Agarwal, Soojin Park, E Sander Connolly, Jan Claassen
Importance: Periodic discharges (PDs) that do not meet seizure criteria, also termed the ictal interictal continuum, are pervasive on electroencephalographic (EEG) recordings after acute brain injury. However, their association with brain homeostasis and the need for clinical intervention remain unknown. Objective: To determine whether distinct PD patterns can be identified that, similar to electrographic seizures, cause brain tissue hypoxia, a measure of ongoing brain injury...
January 9, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28097310/combined-intravenous-thrombolysis-and-thrombectomy-vs-thrombectomy-alone-for-acute-ischemic-stroke-a-pooled-analysis-of-the-swift-and-star-studies
#19
Jonathan M Coutinho, David S Liebeskind, Lee-Anne Slater, Raul G Nogueira, Wayne Clark, Antoni Dávalos, Alain Bonafé, Reza Jahan, Urs Fischer, Jan Gralla, Jeffrey L Saver, Vitor M Pereira
Importance: Mechanical thrombectomy (MT) improves clinical outcomes in patients with acute ischemic stroke (AIS) caused by a large vessel occlusion. However, it is not known whether intravenous thrombolysis (IVT) is of added benefit in patients undergoing MT. Objective: To examine whether treatment with IVT before MT with a stent retriever is beneficial in patients undergoing MT. Design, Setting, and Participants: This post hoc analysis used data from 291 patients treated with MT included in 2 large, multicenter, prospective clinical trials that evaluated MT for AIS (Solitaire With the Intention for Thrombectomy performed from January 1, 2010, through December 31, 2011, and Solitaire Flow Restoration Thrombectomy for Acute Revascularization from January 1, 2010, through December 31, 2012)...
January 9, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28097042/the-relaxant-activity-of-safranal-in-isolated-rat-aortas-is-mediated-predominantly-via-an-endothelium-independent-mechanism-vasodilatory-mechanism-of-safranal
#20
Bibi Marjan Razavi, Mojtaba Alipoor Amanloo, Mohsen Imenshahidi, Hossein Hosseinzadeh
OBJECTIVES: Safranal is a pharmacologically active component of saffron and is responsible for the unique aroma of saffron. The hypotensive effect of safranal has been shown in previous studies. This study evaluates the mechanism for the vasodilatory effects induced by safranal on isolated rat aortas. METHODS: To study the vasodilatory effects of safranal (0.2, 0.4 and 0.8 mM), we contracted isolated rat thoracic aorta rings by using 10(-6)-M phenylephrine (PE) or 80-mM KCl...
December 2016: Journal of Pharmacopuncture
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