Hadas Tamir, Tal Noy-Porat, Sharon Melamed, Lilach Cherry-Mimran, Moria Barlev-Gross, Ron Alcalay, Yfat Yahalom-Ronen, Hagit Achdout, Boaz Politi, Noam Erez, Shay Weiss, Ronit Rosenfeld, Eyal Epstein, Ohad Mazor, Efi Makdasi, Nir Paran, Tomer Israely
The eradication of smallpox was officially declared by the WHO in 1980, leading to discontinuation of the vaccination campaign against the virus. Consequently, immunity against smallpox and related orthopoxviruses like Monkeypox virus gradually declines, highlighting the need for efficient countermeasures not only for the prevention, but also for the treatment of already exposed individuals. We have recently developed human-like monoclonal antibodies (mAbs) from vaccinia virus-immunized non-human primates. Two mAbs, MV33 and EV42, targeting the two infectious forms of the virus, were selected for in vivo evaluation, based on their in vitro neutralization potency...
April 16, 2024: Nature Communications