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C. David Allis

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https://www.readbyqxmd.com/read/30217363/pursuing-the-secrets-of-histone-proteins-an-amazing-journey-with-a-remarkable-supporting-cast
#1
C David Allis
No abstract text is available yet for this article.
September 7, 2018: Cell
https://www.readbyqxmd.com/read/30019584/correction-to-dipicolinic-acid-derivatives-as-inhibitors-of-new-delhi-metallo-%C3%AE-lactamase-1
#2
Allie Y Chen, Pei W Thomas, Alesha C Stewart, Alexander Bergstrom, Zishuo Cheng, Callie Miller, Christopher R Bethel, Steven H Marshall, Cy V Credille, Christopher L Riley, Richard C Page, Robert A Bonomo, Michael W Crowder, David L Tierney, Walter Fast, Seth M Cohen
No abstract text is available yet for this article.
July 26, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29968525/patient-safety-quality-improvement-primer-part-i-what-ps-qi-means-to-your-otolaryngology-practice
#3
Michael J Brenner, C W David Chang, Emily F Boss, Julie L Goldman, Richard M Rosenfeld, Cecelia E Schmalbach
Patient safety/quality improvement (PS/QI) is the cornerstone of 21st-century health care. Otolaryngology-Head and Neck Surgery is excited to provide a dedicated PS/QI primer. The overarching goal for this PS/QI series is to provide a comprehensive and practical resource that assists readers, authors, and peer reviewers in understanding PS/QI research, its unique methodology, and the associated reporting standards for trustworthy performance measures. The target audience includes resident and fellows, faculty from the private sector and academia, and allied health professionals...
July 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29944902/managing-nicotine-without-smoke-to-save-lives-now-evidence-for-harm-minimization
#4
David B Abrams, Allison M Glasser, Andrea C Villanti, Jennifer L Pearson, Shyanika Rose, Raymond S Niaura
Tobacco control has made strides in prevention and cessation, but deaths will not decline rapidly without massive behavior change. Currently, inhaled smoke from combusting tobacco is chiefly responsible for prematurely killing 7.2 million people worldwide and 530,000 in the United States annually. An array of noncombustible nicotine products (NNPs) has emerged and has disrupted the marketplace. Saving lives more speedily will require societal acceptance of locating a "sweet spot" within a three-dimensional framework where NNPs are simultaneously: 1...
June 23, 2018: Preventive Medicine
https://www.readbyqxmd.com/read/29935209/the-impact-of-eculizumab-on-routine-complement-assays
#5
Maria A V Willrich, Bruna D Andreguetto, Meera Sridharan, Fernando C Fervenza, Linda J Tostrud, Paula M Ladwig, Ann M Rivard, MeLea D Hetrick, Ryan N Olson, Sandra C Bryant, Melissa R Snyder, David L Murray
BACKGROUND: Eculizumab (ECU) blocks complement C5 cleavage, preventing the formation of C5a and the cytolytic effects of the membrane attack complex. The presence of ECU in blood impacts routine complement tests used to monitor treatment. METHODS: Residual serum samples with normal total complement (CH50) and residual citrate plasma with normal PT/APTT were spiked with ECU at varied concentrations ranging from 25 to 600 μg/mL. In addition, seventy-one samples from patients on ECU were obtained...
September 2018: Journal of Immunological Methods
https://www.readbyqxmd.com/read/29847798/nmda-receptor-activation-underlies-the-loss-of-spinal-dorsal-horn-neurons-and-the-transition-to-persistent-pain-after-peripheral-nerve-injury
#6
Perrine Inquimbert, Martin Moll, Alban Latremoliere, Chi-Kun Tong, John Whang, Gregory F Sheehan, Brendan M Smith, Erica Korb, Maria C P Athié, Olusegun Babaniyi, Nader Ghasemlou, Yuchio Yanagawa, C David Allis, Patrick R Hof, Joachim Scholz
Peripheral nerve lesions provoke apoptosis in the dorsal horn of the spinal cord. The cause of cell death, the involvement of neurons, and the relevance for the processing of somatosensory information are controversial. Here, we demonstrate in a mouse model of sciatic nerve injury that glutamate-induced neurodegeneration and loss of γ-aminobutyric acid (GABA)ergic interneurons in the superficial dorsal horn promote the transition from acute to chronic neuropathic pain. Conditional deletion of Grin1, the essential subunit of N-methyl-d-aspartate-type glutamate receptors (NMDARs), protects dorsal horn neurons from excitotoxicity and preserves GABAergic inhibition...
May 29, 2018: Cell Reports
https://www.readbyqxmd.com/read/29797088/the-structure-of-the-cgrp-and-related-receptors
#7
John Simms, Sarah Routledge, Romez Uddin, David Poyner
The canonical CGRP receptor is a complex between calcitonin receptor-like receptor (CLR), a family B G-protein-coupled receptor (GPCR) and receptor activity-modifying protein 1 (RAMP1). A third protein, receptor component protein (RCP) is needed for coupling to Gs. CGRP can interact with other RAMP-receptor complexes, particularly the AMY1 receptor formed between the calcitonin receptor (CTR) and RAMP1. Crystal structures are available for the binding of CGRP27-37 [D31 ,P34 ,F35 ] to the extracellular domain (ECD) of CLR and RAMP1; these show that extreme C-terminal amide of CGRP interacts with W84 of RAMP1 but the rest of the analogue interacts with CLR...
May 25, 2018: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/29662175/pluripotency-transcription-factors-and-tet1-2-maintain-brd4-independent-stem-cell-identity
#8
Lydia W S Finley, Santosha A Vardhana, Bryce W Carey, Direna Alonso-Curbelo, Richard Koche, Yanyang Chen, Duancheng Wen, Bryan King, Megan R Radler, Shahin Rafii, Scott W Lowe, C David Allis, Craig B Thompson
A robust network of transcription factors and an open chromatin landscape are hallmarks of the naive pluripotent state. Recently, the acetyllysine reader Brd4 has been implicated in stem cell maintenance, but the relative contribution of Brd4 to pluripotency remains unclear. Here, we show that Brd4 is dispensable for self-renewal and pluripotency of embryonic stem cells (ESCs). When maintained in their ground state, ESCs retain transcription factor binding and chromatin accessibility independent of Brd4 function or expression...
May 2018: Nature Cell Biology
https://www.readbyqxmd.com/read/29659046/polyethylene-glycol-treated-allografts-not-tissue-matched-nor-immunosuppressed-rapidly-repair-sciatic-nerve-gaps-maintain-neuromuscular-functions-and-restore-voluntary-behaviors-in-female-rats
#9
Michelle Mikesh, Cameron L Ghergherehchi, Sina Rahesh, Karthik Jagannath, Amir Ali, Dale R Sengelaub, Richard C Trevino, David M Jackson, Haley O Tucker, George D Bittner
Many publications report that ablations of segments of peripheral nerves produce the following unfortunate results: (1) Immediate loss of sensory signaling and motor control; (2) rapid Wallerian degeneration of severed distal axons within days; (3) muscle atrophy within weeks; (4) poor behavioral (functional) recovery after many months, if ever, by slowly-regenerating (∼1mm/d) axon outgrowths from surviving proximal nerve stumps; and (5) Nerve allografts to repair gap injuries are rejected, often even if tissue matched and immunosuppressed...
July 2018: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/29604235/phylogenomic-analyses-reveal-a-deep-history-of-hybridization-and-polyploidy-in-the-neotropical-genus-lachemilla-rosaceae
#10
Diego F Morales-Briones, Aaron Liston, David C Tank
Hybridization, incomplete lineage sorting, and phylogenetic error produce similar incongruence patterns, representing a great challenge for phylogenetic reconstruction. Here, we use sequence capture data and multiple species tree and species network approaches to resolve the backbone phylogeny of the Neotropical genus Lachemilla, while distinguishing among sources of incongruence. We used 396 nuclear loci and nearly complete plastome sequences from 27 species to clarify the relationships among the major groups of Lachemilla, and explored multiple sources of conflict between gene trees and species trees inferred with a plurality of approaches...
June 2018: New Phytologist
https://www.readbyqxmd.com/read/29531101/treating-subthreshold-depression-in-primary-care-a-randomized-controlled-trial-of-behavioral-activation-with-mindfulness
#11
RANDOMIZED CONTROLLED TRIAL
Samuel Y S Wong, Yu Ying Sun, Aaroy T Y Chan, Maria K W Leung, David V K Chao, Carole C K Li, King K H Chan, Wai Kwong Tang, Trevor Mazzucchelli, Alma M L Au, Benjamin H K Yip
PURPOSE: We undertook a randomized controlled trial to assess the efficacy of group-based behavioral activation with mindfulness (BAM) for treating subthreshold depression in primary care in Hong Kong. METHODS: We recruited adult patients aged 18 years or older with subthreshold depression from public primary care clinics and randomly assigned them to a BAM intervention group or a usual care group. The BAM group was provided with eight 2-hour weekly BAM sessions by trained allied health care workers...
March 2018: Annals of Family Medicine
https://www.readbyqxmd.com/read/29461514/a-large-open-source-dataset-of-stroke-anatomical-brain-images-and-manual-lesion-segmentations
#12
Sook-Lei Liew, Julia M Anglin, Nick W Banks, Matt Sondag, Kaori L Ito, Hosung Kim, Jennifer Chan, Joyce Ito, Connie Jung, Nima Khoshab, Stephanie Lefebvre, William Nakamura, David Saldana, Allie Schmiesing, Cathy Tran, Danny Vo, Tyler Ard, Panthea Heydari, Bokkyu Kim, Lisa Aziz-Zadeh, Steven C Cramer, Jingchun Liu, Surjo Soekadar, Jan-Egil Nordvik, Lars T Westlye, Junping Wang, Carolee Winstein, Chunshui Yu, Lei Ai, Bonhwang Koo, R Cameron Craddock, Michael Milham, Matthew Lakich, Amy Pienta, Alison Stroud
Stroke is the leading cause of adult disability worldwide, with up to two-thirds of individuals experiencing long-term disabilities. Large-scale neuroimaging studies have shown promise in identifying robust biomarkers (e.g., measures of brain structure) of long-term stroke recovery following rehabilitation. However, analyzing large rehabilitation-related datasets is problematic due to barriers in accurate stroke lesion segmentation. Manually-traced lesions are currently the gold standard for lesion segmentation on T1-weighted MRIs, but are labor intensive and require anatomical expertise...
February 20, 2018: Scientific Data
https://www.readbyqxmd.com/read/29395070/engineering-of-a-histone-recognition-domain-in-dnmt3a-alters-the-epigenetic-landscape-and-phenotypic-features-of-mouse-escs
#13
Kyung-Min Noh, Haibo Wang, Hyunjae R Kim, Wendy Wenderski, Fang Fang, Charles H Li, Scott Dewell, Stephen H Hughes, Ari M Melnick, Dinshaw J Patel, Haitao Li, C David Allis
No abstract text is available yet for this article.
February 1, 2018: Molecular Cell
https://www.readbyqxmd.com/read/29395069/greater-than-the-sum-of-parts-complexity-of-the-dynamic-epigenome
#14
Alexey A Soshnev, Steven Z Josefowicz, C David Allis
No abstract text is available yet for this article.
February 1, 2018: Molecular Cell
https://www.readbyqxmd.com/read/29395068/intracellular-crotonyl-coa-stimulates-transcription-through-p300-catalyzed-histone-crotonylation
#15
Benjamin R Sabari, Zhanyun Tang, He Huang, Vladimir Yong-Gonzalez, Henrik Molina, Ha Eun Kong, Lunzhi Dai, Miho Shimada, Justin R Cross, Yingming Zhao, Robert G Roeder, C David Allis
No abstract text is available yet for this article.
February 1, 2018: Molecular Cell
https://www.readbyqxmd.com/read/29367334/2018-guidelines-for-the-early-management-of-patients-with-acute-ischemic-stroke-a-guideline-for-healthcare-professionals-from-the-american-heart-association-american-stroke-association
#16
REVIEW
William J Powers, Alejandro A Rabinstein, Teri Ackerson, Opeolu M Adeoye, Nicholas C Bambakidis, Kyra Becker, José Biller, Michael Brown, Bart M Demaerschalk, Brian Hoh, Edward C Jauch, Chelsea S Kidwell, Thabele M Leslie-Mazwi, Bruce Ovbiagele, Phillip A Scott, Kevin N Sheth, Andrew M Southerland, Deborah V Summers, David L Tirschwell
BACKGROUND AND PURPOSE: The purpose of these guidelines is to provide an up-to-date comprehensive set of recommendations for clinicians caring for adult patients with acute arterial ischemic stroke in a single document. The intended audiences are prehospital care providers, physicians, allied health professionals, and hospital administrators. These guidelines supersede the 2013 guidelines and subsequent updates. METHODS: Members of the writing group were appointed by the American Heart Association Stroke Council's Scientific Statements Oversight Committee, representing various areas of medical expertise...
March 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29358330/histone-variant-h3-3-mediated-chromatin-remodeling-is-essential-for-paternal-genome-activation-in-mouse-preimplantation-embryos
#17
Qingran Kong, Laura A Banaszynski, Fuqiang Geng, Xiaolei Zhang, Jiaming Zhang, Heng Zhang, Claire L O'Neill, Peidong Yan, Zhonghua Liu, Koji Shido, Gianpiero D Palermo, C David Allis, Shahin Rafii, Zev Rosenwaks, Duancheng Wen
Derepression of chromatin-mediated transcriptional repression of paternal and maternal genomes is considered the first major step that initiates zygotic gene expression after fertilization. The histone variant H3.3 is present in both male and female gametes and is thought to be important for remodeling the paternal and maternal genomes for activation during both fertilization and embryogenesis. However, the underlying mechanisms remain poorly understood. Using our H3.3B-HA-tagged mouse model, engineered to report H3...
March 9, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29357876/training-scholars-in-dissemination-and-implementation-research-for-cancer-prevention-and-control-a-mentored-approach
#18
Margaret Padek, Nageen Mir, Rebekah R Jacob, David A Chambers, Maureen Dobbins, Karen M Emmons, Jon Kerner, Shiriki Kumanyika, Christine Pfund, Enola K Proctor, Kurt C Stange, Ross C Brownson
BACKGROUND: As the field of D&I (dissemination and implementation) science grows to meet the need for more effective and timely applications of research findings in routine practice, the demand for formalized training programs has increased concurrently. The Mentored Training for Dissemination and Implementation Research in Cancer (MT-DIRC) Program aims to build capacity in the cancer control D&I research workforce, especially among early career researchers. This paper outlines the various components of the program and reports results of systematic evaluations to ascertain its effectiveness...
January 22, 2018: Implementation Science: IS
https://www.readbyqxmd.com/read/29239647/the-transfer-of-category-knowledge-by-macaques-macaca-mulatta-and-humans-homo-sapiens
#19
Alexandria C Zakrzewski, Barbara A Church, J David Smith
Cognitive psychologists distinguish implicit, procedural category learning (stimulus-response associations learned outside declarative cognition) from explicit-declarative category learning (conscious category rules). These systems are dissociated by category learning tasks with either a multidimensional, information-integration (II) solution or a unidimensional, rule-based (RB) solution. In the present experiments, humans and two monkeys learned II and RB category tasks fostering implicit and explicit learning, respectively...
February 2018: Journal of Comparative Psychology
https://www.readbyqxmd.com/read/29123913/sex-hormone-status-in-women-with-chronic-kidney-disease-survey-of-nephrologists-and-renal-allied-health-care-providers-perceptions
#20
Sharanya Ramesh, Matthew T James, Jayna M Holroyd-Leduc, Stephen B Wilton, Ellen W Seely, David C Wheeler, Sofia B Ahmed
Background: Chronic kidney disease (CKD) in reproductive-age women is accompanied by menstrual and fertility disorders and premature menopause. Objective: We sought to determine nephrologists' and allied health care providers' perceptions on management of sex hormone status in women with CKD. Methods: An anonymous, Internet-based survey was sent to nephrology society members from Canada, Australia, New Zealand, and the United Kingdom, and the Canadian Association of Nephrology Nurses and Technologists (February-November 2015)...
2017: Canadian Journal of Kidney Health and Disease
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