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David Allis

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https://www.readbyqxmd.com/read/29760961/ctx-m-15-is-established-in-most-multidrug-resistant-uropathogenic-enterobacteriaceae-and-pseudomonaceae-from-hospitals-in-nigeria
#1
David Olusoga Ogbolu, O A Terry Alli, Mark Alexander Webber, Adeolu Sunday Oluremi, Omoboriowo Moses Oloyede
β-Lactam antibiotics are widely used to treat urinary tract infections in Nigeria. This study aimed to determine the presence and characteristics of extended spectrum β-lactamases in commonly isolated uropathogenic Gram-negative bacteria (GNB) in Nigeria. Fifty non-duplicate GNB isolates consisting of Escherichia coli , 19; Klebsiella pneumoniae , 21; and Pseudomonas aeruginosa , 10 were obtained from three tertiary hospitals in Nigeria. The antibiotic susceptibility testing of all isolates to a panel of antibiotics including minimum inhibitory concentrations (MICs) and extended spectrum β-lactamases was determined...
April 2018: European Journal of Microbiology & Immunology
https://www.readbyqxmd.com/read/29753336/an-important-milestone-in-parasitology-celebrating-a-hundred-volumes-of-advances-in-parasitology
#2
J Russell Stothard, David Rollinson
Beginning in 1963, the founding rationale of Advances in Parasitology was to provide authentic, well-documented reviews by leading experts, about the progress being made in their area of specialism to inform the wider cadre of parasitologists, disseminating this information across allied disciplines and all users. Some 55 years later, the Series has accumulated over 667 published articles, with just over 650 authors contributing either alone or in collaboration, and has successfully served the parasitological needs of medical, veterinary and wildlife scientific communities with equity, notwithstanding treatises on vectors or intermediate hosts, as well as 'honorary parasites' such as viruses, bacteria and fungi...
2018: Advances in Parasitology
https://www.readbyqxmd.com/read/29687415/how-mentor-support-interacts-with-mother-and-teacher-support-in-predicting-youth-academic-adjustment-an-investigation-among-youth-exposed-to-big-brothers-big-sisters-of-canada-programs
#3
Simon Larose, Geneviève Boisclair-Châteauvert, David J De Wit, David DuBois, Gizem Erdem, Ellen L Lipman
This study examines three potential contributions (i.e., additive only, hierarchical compensatory, and hierarchical conditional) of mentor support to youth academic adjustment, taking into account interactions with support from mothers and teachers. We derived data from a larger study of the Big Brothers Big Sisters (BBBS) of Canada community mentoring program. The sample included 427 youth (average age 9.8 years; 64% girls, 56% White) who received one-to-one community-based mentoring for at least three months...
April 23, 2018: Journal of Primary Prevention
https://www.readbyqxmd.com/read/29684234/systemic-treatment-options-for-brain-metastases-from-non-small-cell-lung-cancer
#4
REVIEW
Ajaz Bulbul, Patrick M Forde, Ayesha Murtuza, Brian Woodward, Hannah Yang, Ingmar Bastian, Parissa K Ferguson, Fernando Lopez-Diaz, David S Ettinger, Hatim Husain
Brain metastases are common in patients with non-small-cell lung cancer (NSCLC). Because of associated poor prognosis and limited specific treatment options, there is a real need for the development of medical therapies and strategies for affected patients. Novel compounds for epidermal growth factor receptor-dependent and anaplastic lymphoma kinase-dependent lung cancer have demonstrated blood-brain barrier permeability and have led to important improvements in central nervous system outcomes. Studies of targeted therapies for oncogene-driven tumors and of immunotherapies in patients with brain metastases have shown promise and, allied with novel radiation techniques, are driving a rapid evolution in treatment and prognosis for NSCLC brain metastases...
April 15, 2018: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/29662175/pluripotency-transcription-factors-and-tet1-2-maintain-brd4-independent-stem-cell-identity
#5
Lydia W S Finley, Santosha A Vardhana, Bryce W Carey, Direna Alonso-Curbelo, Richard Koche, Yanyang Chen, Duancheng Wen, Bryan King, Megan R Radler, Shahin Rafii, Scott W Lowe, C David Allis, Craig B Thompson
A robust network of transcription factors and an open chromatin landscape are hallmarks of the naive pluripotent state. Recently, the acetyllysine reader Brd4 has been implicated in stem cell maintenance, but the relative contribution of Brd4 to pluripotency remains unclear. Here, we show that Brd4 is dispensable for self-renewal and pluripotency of embryonic stem cells (ESCs). When maintained in their ground state, ESCs retain transcription factor binding and chromatin accessibility independent of Brd4 function or expression...
April 16, 2018: Nature Cell Biology
https://www.readbyqxmd.com/read/29659046/polyethylene-glycol-treated-allografts-not-tissue-matched-nor-immunosuppressed-rapidly-repair-sciatic-nerve-gaps-maintain-neuromuscular-functions-and-restore-voluntary-behaviors-in-female-rats
#6
Michelle Mikesh, Cameron L Ghergherehchi, Sina Rahesh, Karthik Jagannath, Amir Ali, Dale R Sengelaub, Richard C Trevino, David M Jackson, Haley O Tucker, George D Bittner
Many publications report that ablations of segments of peripheral nerves produce the following unfortunate results: (1) Immediate loss of sensory signaling and motor control; (2) rapid Wallerian degeneration of severed distal axons within days; (3) muscle atrophy within weeks; (4) poor behavioral (functional) recovery after many months, if ever, by slowly-regenerating (∼1mm/d) axon outgrowths from surviving proximal nerve stumps; and (5) Nerve allografts to repair gap injuries are rejected, often even if tissue matched and immunosuppressed...
April 16, 2018: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/29626050/impact-of-multimorbidity-count-on-all-cause-mortality-and-glycaemic-outcomes-in-people-with-type-2-diabetes-a-systematic-review-protocol
#7
Jason I Chiang, John Furler, Frances S Mair, Bhautesh Jani, Barbara I Nicholl, Alicia Jenkins, Patrick Condron, David O'Neal, Jo-Anne Manski-Nankervis
INTRODUCTION: Type 2 diabetes (T2D) is a leading health priority worldwide. Multimorbidity (MM) is a term describing the co-occurrence of two or more chronic diseases or conditions. The majority of people living with T2D have MM. The relationship between MM and mortality and glycaemia in people with T2D is not clear. METHODS AND ANALYSIS: Medline, Embase, Cumulative Index of Nursing and Allied Health Complete, The Cochrane Library, and SCOPUS will be searched with a prespecified search strategy...
April 5, 2018: BMJ Open
https://www.readbyqxmd.com/read/29620523/an-incoherent-feedforward-loop-facilitates-adaptive-tuning-of-gene-expression
#8
Jungeui Hong, Nathan Brandt, Farah Abdual-Rahman, Ally W H Yang, Timothy R Hughes, David Gresham
We studied adaptive evolution of gene expression using long-term experimental evolution of Saccharomyces cerevisiae in ammonium-limited chemostats. We found repeated selection for non-synonymous variation in the DNA binding domain of the transcriptional activator, GAT1, which functions with the repressor, DAL80 in an incoherent type-1 feedforward loop (I1-FFL) to control expression of the high affinity ammonium transporter gene, MEP2. Missense mutations in the DNA binding domain of GAT1 reduce its binding to the GATAA consensus sequence...
April 5, 2018: ELife
https://www.readbyqxmd.com/read/29604235/phylogenomic-analyses-reveal-a-deep-history-of-hybridization-and-polyploidy-in-the-neotropical-genus-lachemilla-rosaceae
#9
Diego F Morales-Briones, Aaron Liston, David C Tank
Hybridization, incomplete lineage sorting, and phylogenetic error produce similar incongruence patterns, representing a great challenge for phylogenetic reconstruction. Here, we use sequence capture data and multiple species tree and species network approaches to resolve the backbone phylogeny of the Neotropical genus Lachemilla, while distinguishing among sources of incongruence. We used 396 nuclear loci and nearly complete plastome sequences from 27 species to clarify the relationships among the major groups of Lachemilla, and explored multiple sources of conflict between gene trees and species trees inferred with a plurality of approaches...
March 31, 2018: New Phytologist
https://www.readbyqxmd.com/read/29536939/defining-the-critical-role-of-nurses-in-diagnostic-error-prevention-a-conceptual-framework-and-a-call-to-action
#10
REVIEW
Kelly T Gleason, Patricia M Davidson, Elizabeth K Tanner, Diana Baptiste, Cynda Rushton, Jennifer Day, Melinda Sawyer, Deborah Baker, Lori Paine, Cheryl R Dennison Himmelfarb, David E Newman-Toker
Nurses have always been involved in the diagnostic process, but there remains a pervasive view across physicians, nurses, and allied health professionals that medical diagnosis is solely a physician responsibility. There is an urgent need to adjust this view and for nurses to take part in leading efforts addressing diagnostic errors. The purpose of this article is to define a framework for nursing engagement in the diagnostic process that can serve as a catalyst for nurses to engage in eliminating preventable harms from diagnostic error...
November 27, 2017: Diagnosis
https://www.readbyqxmd.com/read/29531101/treating-subthreshold-depression-in-primary-care-a-randomized-controlled-trial-of-behavioral-activation-with-mindfulness
#11
Samuel Y S Wong, Yu Ying Sun, Aaroy T Y Chan, Maria K W Leung, David V K Chao, Carole C K Li, King K H Chan, Wai Kwong Tang, Trevor Mazzucchelli, Alma M L Au, Benjamin H K Yip
PURPOSE: We undertook a randomized controlled trial to assess the efficacy of group-based behavioral activation with mindfulness (BAM) for treating subthreshold depression in primary care in Hong Kong. METHODS: We recruited adult patients aged 18 years or older with subthreshold depression from public primary care clinics and randomly assigned them to a BAM intervention group or a usual care group. The BAM group was provided with eight 2-hour weekly BAM sessions by trained allied health care workers...
March 2018: Annals of Family Medicine
https://www.readbyqxmd.com/read/29530911/comparative-efficacy-and-acceptability-of-psychotherapies-for-post-traumatic-stress-disorder-in-children-and-adolescents-study-protocol-for-a-systematic-review-and-network-meta-analysis
#12
Yuqing Zhang, Xinyu Zhou, Lining Yang, Sarah E Hetrick, John R Weisz, Pim Cuijpers, Jürgen Barth, Cinzia Del Giovane, Shuai Yuan, David Cohen, Donna Gillies, Xiaofeng Jiang, Teng Teng, Peng Xie
INTRODUCTION: Post-traumatic stress disorder (PTSD) is common among children and adolescents who are exposed to trauma, and it is often associated with significant negative impacts on their psychosocial functioning and quality of life. Many types of psychotherapies have been found to be effective for PTSD in children and adolescents. However, due to the lack of direct comparisons between different psychotherapies, the hierarchy of treatment efficacy is still unclear. Therefore, we plan to conduct a systematic review and network meta-analysis to evaluate the efficacy and acceptability of various types of psychotherapies for PTSD in children and adolescents...
March 12, 2018: BMJ Open
https://www.readbyqxmd.com/read/29530906/influence-of-military-component-and-deployment-related-experiences-on-mental-disorders-among-canadian-military-personnel-who-deployed-to-afghanistan-a-cross-sectional-survey
#13
David Boulos, Deniz Fikretoglu
OBJECTIVE: The primary objective was to explore differences in mental health problems (MHP) between serving Canadian Armed Forces (CAF) components (Regular Force (RegF); Reserve Force (ResF)) with an Afghanistan deployment and to assess the contribution of both component and deployment experiences to MHP using covariate-adjusted prevalence difference estimates. Additionally, mental health services use (MHSU) was descriptively assessed among those with a mental disorder. DESIGN: Data came from the 2013 CAF Mental Health Survey, a cross-sectional survey of serving personnel (n=72 629)...
March 12, 2018: BMJ Open
https://www.readbyqxmd.com/read/29519859/treating-people-with-arthritis-with-traditional-chinese-medicine-tcm-an-examination-of-the-perception-of-tcm-practitioners
#14
Lu Yang, Wenbo Peng, Jon Adams, David William Sibbritt
INTRODUCTION: Emerging evidence has shown that traditional Chinese medicine (TCM) has a positive effect on arthritis. This research provides the first critical, systematic examination of TCM practitioners' perceptions of TCM use for people with arthritis. METHODS: An online survey was distributed to all TCM professionals including acupuncturists and Chinese herbal medicine practitioners registered with the Practitioner Research and Collaborate Initiative (PRACI) practitioner database...
March 8, 2018: Acupuncture in Medicine: Journal of the British Medical Acupuncture Society
https://www.readbyqxmd.com/read/29505664/higher-versus-lower-amino-acid-intake-in-parenteral-nutrition-for-newborn-infants
#15
REVIEW
David A Osborn, Tim Schindler, Lisa J Jones, John Kh Sinn, Srinivas Bolisetty
BACKGROUND: Sick newborn and preterm infants frequently are not able to be fed enterally, necessitating parenteral fluid and nutrition. Potential benefits of higher parenteral amino acid (AA) intake for improved nitrogen balance, growth, and infant health may be outweighed by the infant's ability to utilise high intake of parenteral AA, especially in the days after birth. OBJECTIVES: The primary objective is to determine whether higher versus lower intake of parenteral AA is associated with improved growth and disability-free survival in newborn infants receiving parenteral nutrition...
March 5, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29463965/a-literature-review-of-electronic-health-records-in-chiropractic-practice-common-challenges-and-solutions
#16
REVIEW
David N Taylor
Objective: The purpose of this study was to review the literature on current challenges and propose solutions for the optimal utilization of the electronic health records (EHRs) in chiropractic practice. Methods: A search was performed in the PubMed, Index of Chiropractic Literature, and Current Index to Nursing and Allied Health Literature databases from November 2005 to February 2015. A combination of the following key words was used: electronic health records , electronic medical records , implementation , documentation , benefits , and challenges ...
December 2017: Journal of Chiropractic Humanities
https://www.readbyqxmd.com/read/29461514/a-large-open-source-dataset-of-stroke-anatomical-brain-images-and-manual-lesion-segmentations
#17
Sook-Lei Liew, Julia M Anglin, Nick W Banks, Matt Sondag, Kaori L Ito, Hosung Kim, Jennifer Chan, Joyce Ito, Connie Jung, Nima Khoshab, Stephanie Lefebvre, William Nakamura, David Saldana, Allie Schmiesing, Cathy Tran, Danny Vo, Tyler Ard, Panthea Heydari, Bokkyu Kim, Lisa Aziz-Zadeh, Steven C Cramer, Jingchun Liu, Surjo Soekadar, Jan-Egil Nordvik, Lars T Westlye, Junping Wang, Carolee Winstein, Chunshui Yu, Lei Ai, Bonhwang Koo, R Cameron Craddock, Michael Milham, Matthew Lakich, Amy Pienta, Alison Stroud
Stroke is the leading cause of adult disability worldwide, with up to two-thirds of individuals experiencing long-term disabilities. Large-scale neuroimaging studies have shown promise in identifying robust biomarkers (e.g., measures of brain structure) of long-term stroke recovery following rehabilitation. However, analyzing large rehabilitation-related datasets is problematic due to barriers in accurate stroke lesion segmentation. Manually-traced lesions are currently the gold standard for lesion segmentation on T1-weighted MRIs, but are labor intensive and require anatomical expertise...
February 20, 2018: Scientific Data
https://www.readbyqxmd.com/read/29452874/quality-of-prostate-cancer-screening-information-on-the-websites-of-nationally-recognized-cancer-centers-and-health-organizations
#18
Bogdan-Alexandru Manole, Daniel V Wakefield, Austin P Dove, Caleb R Dulaney, Samuel R Marcrom, David L Schwartz, Michael R Farmer
PURPOSE: The purpose of this study was to survey the accessibility and quality of prostate-specific antigen (PSA) screening information from National Cancer Institute (NCI) cancer center and public health organization Web sites. METHODS AND MATERIALS: We surveyed the December 1, 2016, version of all 63 NCI-designated cancer center public Web sites and 5 major online clearinghouses from allied public/private organizations (cancer.gov, cancer.org, PCF.org, USPSTF...
December 24, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29450836/allied-health-professionals-knowledge-and-use-of-asd-intervention-practices
#19
Jessica Paynter, Rhylee Sulek, Sarah Luskin-Saxby, David Trembath, Deb Keen
Allied health professionals (AHPs) are trusted sources of information and intervention for clients with autism spectrum disorder. However, the level of implementation of empirically-supported therapies and the accuracy of the knowledge they use to inform intervention selection is largely unknown. The present study explored the accuracy of AHPs' knowledge and use of practices, and explored links to individual attitudes and organisational culture. Overall results from the 156 AHPs surveyed suggested general accuracy of knowledge, and use of empirically supported treatments, with accuracy linked to use...
February 15, 2018: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29431025/highlighting-the-clinical-need-for-diagnosing-mycoplasma-genitalium-infection
#20
Catherine A Ison, Helen Fifer, Simon Gwynn, Paddy Horner, Peter Muir, Jane Nicholls, Keith Radcliffe, Jonathan Ross, David Taylor-Robinson, John White
Despite Mycoplasma genitalium (MG) being increasingly recognised as a genital pathogen in men and women, awareness and utility of commercially available MG-testing has been low. The opinion of UK sexual health clinicians and allied professionals was sought on how MG-testing should be used. Thirty-two consensus statements were developed by an expert group and circulated to clinicians and laboratory staff, who were asked to evaluate their level of agreement with each statement; 75% agreement was set as the threshold for defining consensus for each statement...
January 1, 2018: International Journal of STD & AIDS
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