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David Allis

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https://www.readbyqxmd.com/read/29132780/sustainable-wineries-through-waste-valorisation-a-review-of-grape-marc-utilisation-for-value-added-products
#1
REVIEW
Richard A Muhlack, Ravichandra Potumarthi, David W Jeffery
Grapes are one of the most cultivated fruits worldwide, with one third of total production used in winemaking. Both red and white winemaking processes result in substantial quantities of solid organic waste, such as grape marc (pomace) and stalks, which requires suitable disposal. Grape marc accounts for approximately 10-30% of the mass of grapes crushed and contains unfermented sugars, alcohol, polyphenols, tannins, pigments, and other valuable products. Being a natural plant product rich in lignocellulosic compounds, grape marc is also a promising feedstock for renewable energy production...
November 10, 2017: Waste Management
https://www.readbyqxmd.com/read/29123913/sex-hormone-status-in-women-with-chronic-kidney-disease-survey-of-nephrologists-and-renal-allied-health-care-providers-perceptions
#2
Sharanya Ramesh, Matthew T James, Jayna M Holroyd-Leduc, Stephen B Wilton, Ellen W Seely, David C Wheeler, Sofia B Ahmed
Background: Chronic kidney disease (CKD) in reproductive-age women is accompanied by menstrual and fertility disorders and premature menopause. Objective: We sought to determine nephrologists' and allied health care providers' perceptions on management of sex hormone status in women with CKD. Methods: An anonymous, Internet-based survey was sent to nephrology society members from Canada, Australia, New Zealand, and the United Kingdom, and the Canadian Association of Nephrology Nurses and Technologists (February-November 2015)...
2017: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/29120265/do-journal-clubs-work-the-effectiveness-of-journal-clubs-in-a-clinical-pastoral-education-residency-program
#3
David Fleenor, Vanshdeep Sharma, Jo Hirschmann, Heidi Swarts
Journal clubs are an established means of ongoing learning in medicine. Beginning with physicians in the nineteenth century, journal clubs have gradually become established in nursing and other allied health professions. However, their use in Clinical Pastoral Education (CPE) is relatively new. We describe the creation of a journal club for CPE residents and discuss the lessons learned from this effort. Over two years, a journal club was conducted with two different cohorts of residents. Residents were surveyed regarding the perceived strengths and weaknesses of the journal club and their recommendations for improvement...
November 9, 2017: Journal of Health Care Chaplaincy
https://www.readbyqxmd.com/read/29119235/effect-of-probiotics-and-synbiotics-consumption-on-serum-concentrations-of-liver-function-test-enzymes-a-systematic-review-and-meta-analysis
#4
REVIEW
Saman Khalesi, David Wayne Johnson, Katrin Campbell, Susan Williams, Andrew Fenning, Sonia Saluja, Christopher Irwin
PURPOSE: The gut-liver interaction suggests that modification of gut bacterial flora using probiotics and synbiotics may improve liver function. This systematic review and meta-analysis aimed to clarify the effect of probiotics and synbiotics consumption on the serum concentration of liver function enzymes. METHODS: PubMed (MEDLINE), Cumulative Index to Nursing and Allied Health Literature, and Cochrane Library (Central) were searched from 1980 to August 2017 for studies where adults consumed probiotics and/or synbiotics in controlled trials and changes in liver function enzymes were examined...
November 8, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/29110686/oncology-practitioners-perspectives-and-practice-patterns-of-post-treatment-cancer-survivorship-care-in-the-asia-pacific-region-results-from-the-step-study
#5
Raymond Javan Chan, Patsy Yates, Qiuping Li, Hiroko Komatsu, Violeta Lopez, Myat Thandar, Selva Titus Chacko, Winnie Kwok Wei So, Kanaungnit Pongthavornkamol, Myungsun Yi, Pongpak Pittayapan, Jessica Butcon, David Wyld, Alex Molassiotis
BACKGROUND: Most efforts to advance cancer survivorship care have occurred in Western countries. There has been limited research towards gaining a comprehensive understanding of survivorship care provision in the Asia-Pacific region. This study aimed to establish the perceptions of responsibility, confidence, and frequency of survivorship care practices of oncology practitioners and examine their perspectives on factors that impede quality survivorship care. METHODS: A cross-sectional survey of hospital-based oncology practitioners in 10 Asia-Pacific countries was undertaken between May 2015-October 2016...
November 6, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29105870/service-learning-partnerships-features-that-promote-transformational-and-sustainable-rural-and-remote-health-partnerships-and-services
#6
Debra Jones, Lindy McAllister, Robert Dyson, David Lyle
OBJECTIVE: To describe features that promote transformational and sustainable community engaged health partnerships and services in rural and remote Australian locations. DESIGN: A pragmatic qualitative study using focus groups and individual semi-structured interviews. Data were analysed using four stages of data comparison. SETTING: Far west New South Wales, Australia. The health partnership, initiated by primary school principals in 2008, aimed to address allied health service inequities experienced by regional children...
November 6, 2017: Australian Journal of Rural Health
https://www.readbyqxmd.com/read/29098981/what-is-the-definition-of-sports-related-concussion-a-systematic-review
#7
REVIEW
Paul McCrory, Nina Feddermann-Demont, Jiří Dvořák, J David Cassidy, Andrew McIntosh, Pieter E Vos, Ruben J Echemendia, Willem Meeuwisse, Alexander A Tarnutzer
OBJECTIVES: Various definitions for concussion have been proposed, each having its strengths and weaknesses. We reviewed and compared current definitions and identified criteria necessary for an operational definition of sports-related concussion (SRC) in preparation of the 5th Concussion Consensus Conference (Berlin, Germany). We also assessed the role of biomechanical studies in informing an operational definition of SRC. DESIGN: This is a systematic literature review...
June 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29091200/patterns-of-dispensed-non-medical-prescriber-prescriptions-for-antibiotics-in-primary-care-across-england-a-retrospective-analysis
#8
Molly Courtenay, David Gillespie, Rosemary Lim
Objectives: To describe the patterns of dispensed non-medical prescriber (NMP) prescriptions for antibiotics in primary care across England between 2011 and 2015. Methods: A retrospective analysis of dispensed antibiotic prescriptions, written by NMPs and medical prescribers between 2011 and 2015 in primary care in England, obtained from the National Health Service Business Services Authority. Results: Between 2011 and 2015, the number of NMPs (mainly nurses but also pharmacists and small numbers of allied health professionals) in England, who have independent prescribing capability, has risen by over one-third to nearly 30000...
October 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29084100/efficacy-of-telerehabilitation-for-adults-with-traumatic-brain-injury-a-systematic-review
#9
Tamara Ownsworth, Urska Arnautovska, Elizabeth Beadle, David H K Shum, Wendy Moyle
OBJECTIVE: To identify and appraise studies evaluating the efficacy of telerehabilitation for adults with traumatic brain injury (TBI). METHODS: A systematic search of Cochrane Library, MEDLINE, CINAHL (Cumulative Index to Nursing and Allied Health Literature), and PsycINFO databases was conducted from January 1980 to April 23, 2017, for studies evaluating the efficacy of telerehabilitation for adults with TBI. Two reviewers independently assessed articles for eligibility and rated methodological quality using 16 criteria related to internal validity, descriptive, and statistical characteristics...
October 27, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/29073202/questionnaire-survey-of-the-pan-african-trade-in-lion-body-parts
#10
Vivienne L Williams, Andrew J Loveridge, David J Newton, David W Macdonald
The African lion is in decline across its range, and consumptive utilisation and trade of their body parts and skins has been postulated as a cause for concern. We undertook a pan-African questionnaire and literature survey to document informed opinion and evidence for the occurrence of domestic and international trade and consumption in African lion body parts across current and former range states. Sixty-five people from 18 countries participated in the online questionnaire survey (run from July 2014 to May 2015), with information provided for 28 countries (including 20 out of 24 countries believed to have extant populations)...
2017: PloS One
https://www.readbyqxmd.com/read/29061619/a-scoping-review-protocol-on-the-roles-and-tasks-of-peer-reviewers-in-the-manuscript-review-process-in-biomedical-journals
#11
Ketevan Glonti, Daniel Cauchi, Erik Cobo, Isabelle Boutron, David Moher, Darko Hren
INTRODUCTION: The primary functions of peer reviewers are poorly defined. Thus far no body of literature has systematically identified the roles and tasks of peer reviewers of biomedical journals. A clear establishment of these can lead to improvements in the peer review process. The purpose of this scoping review is to determine what is known on the roles and tasks of peer reviewers. METHODS: We will use the methodological framework first proposed by Arksey and O'Malley and subsequently adapted by Levac et al and the Joanna Briggs Institute...
October 22, 2017: BMJ Open
https://www.readbyqxmd.com/read/29045389/molecular-basis-of-usp7-inhibition-by-selective-small-molecule-inhibitors
#12
Andrew P Turnbull, Stephanos Ioannidis, Wojciech W Krajewski, Adan Pinto-Fernandez, Claire Heride, Agnes C L Martin, Louise M Tonkin, Elizabeth C Townsend, Shane M Buker, David R Lancia, Justin A Caravella, Angela V Toms, Thomas M Charlton, Johanna Lahdenranta, Erik Wilker, Bruce C Follows, Nicola J Evans, Lucy Stead, Cristina Alli, Vladislav V Zarayskiy, Adam C Talbot, Alexandre J Buckmelter, Minghua Wang, Crystal L McKinnon, Fabienne Saab, Joanna F McGouran, Hannah Century, Malte Gersch, Marc S Pittman, C Gary Marshall, Tony M Raynham, Mary Simcox, Lorna M D Stewart, Sheila B McLoughlin, Jaime A Escobedo, Kenneth W Bair, Christopher J Dinsmore, Tim R Hammonds, Sunkyu Kim, Sylvie Urbé, Michael J Clague, Benedikt M Kessler, David Komander
Ubiquitination controls the stability of most cellular proteins, and its deregulation contributes to human diseases including cancer. Deubiquitinases remove ubiquitin from proteins, and their inhibition can induce the degradation of selected proteins, potentially including otherwise 'undruggable' targets. For example, the inhibition of ubiquitin-specific protease 7 (USP7) results in the degradation of the oncogenic E3 ligase MDM2, and leads to re-activation of the tumour suppressor p53 in various cancers. Here we report that two compounds, FT671 and FT827, inhibit USP7 with high affinity and specificity in vitro and within human cells...
October 26, 2017: Nature
https://www.readbyqxmd.com/read/29038461/the-bacteroidales-produce-an-n-acylated-derivative-of-glycine-with-both-cholesterol-solubilising-and-hemolytic-activity
#13
Alli Lynch, Elaine Crowley, Eoghan Casey, Rafael Cano, Rachel Shanahan, Ger McGlacken, Julian R Marchesi, David J Clarke
The contribution of the gut microbiota to the metabolism of cholesterol is not well understood. In this study, we identify 21 fosmid clones from a human gut microbiome metagenomic library that, when expressed in Escherichia coli, produce halos on LB agar supplemented with 0.01% (w/v) cholesterol (LBC agar). Analysis of 14 of these clones revealed that they all share a fragment of DNA with homology to the genome of Bacteroides vulgatus. The gene responsible for halo production on LBC agar, named choA, was identified as an N-acyltransferase known to produce an acylated glycine molecule called commendamide...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29030587/natd-promotes-lung-cancer-progression-by-preventing-histone-h4-serine-phosphorylation-to-activate-slug-expression
#14
Junyi Ju, Aiping Chen, Yexuan Deng, Ming Liu, Ying Wang, Yadong Wang, Min Nie, Chao Wang, Hong Ding, Bing Yao, Tao Gui, Xinyu Li, Zhen Xu, Chi Ma, Yong Song, Marc Kvansakul, Ke Zen, Chen-Yu Zhang, Cheng Luo, Ming Fang, David C S Huang, C David Allis, Renxiang Tan, Changjiang Kathy Zeng, Jiwu Wei, Quan Zhao
N-α-acetyltransferase D (NatD) mediates N-α-terminal acetylation (Nt-acetylation) of histone H4 known to be involved in cell growth. Here we report that NatD promotes the migratory and invasive capabilities of lung cancer cells in vitro and in vivo. Depletion of NatD suppresses the epithelial-to-mesenchymal transition (EMT) of lung cancer cells by directly repressing the expression of transcription factor Slug, a key regulator of EMT. We found that Nt-acetylation of histone H4 antagonizes histone H4 serine 1 phosphorylation (H4S1ph), and that downregulation of Nt-acetylation of histone H4 facilitates CK2α binding to histone H4 in lung cancer cells, resulting in increased H4S1ph and epigenetic reprogramming to suppress Slug transcription to inhibit EMT...
October 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/29025114/comprehensive-process-model-of-clinical-information-interaction-in-primary-care-results-of-a-best-fit-framework-synthesis
#15
Tiffany C Veinot, Charles R Senteio, David Hanauer, Julie C Lowery
Objective: To describe a new, comprehensive process model of clinical information interaction in primary care (Clinical Information Interaction Model, or CIIM) based on a systematic synthesis of published research. Materials and Methods: We used the "best fit" framework synthesis approach. Searches were performed in PubMed, Embase, the Cumulative Index to Nursing and Allied Health Literature (CINAHL), PsycINFO, Library and Information Science Abstracts, Library, Information Science and Technology Abstracts, and Engineering Village...
September 2, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29018060/dietary-supplements-for-treating-osteoarthritis-a-systematic-review-and-meta-analysis
#16
REVIEW
Xiaoqian Liu, Gustavo C Machado, Jillian P Eyles, Varshini Ravi, David J Hunter
OBJECTIVE: To investigate the efficacy and safety of dietary supplements for patients with osteoarthritis. DESIGN: An intervention systematic review with random effects meta-analysis and meta-regression. DATA SOURCES: MEDLINE, EMBASE, Cochrane Register of Controlled Trials, Allied and Complementary Medicine and Cumulative Index to Nursing and Allied Health Literature were searched from inception to April 2017. STUDY ELIGIBILITY CRITERIA: Randomised controlled trials comparing oral supplements with placebo for hand, hip or knee osteoarthritis...
October 10, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29016508/prophylactic-negative-pressure-wound-therapy-for-obese-women-after-cesarean-delivery-a-systematic-review-and-meta-analysis
#17
REVIEW
Marcela C Smid, Sarah K Dotters-Katz, Matthew Grace, Sarah T Wright, Margaret S Villers, Abbey Hardy-Fairbanks, David M Stamilio
OBJECTIVE: To summarize available studies on wound complication outcomes after prophylactic negative pressure wound therapy for obese women (body mass index 30 or greater). DATA SOURCES: We conducted a systematic review and meta-analysis using electronic database search (PubMed, Cumulative Index to Nursing and Allied Health Literature, EMBASE, Google scholar, and Web of Science), Cochrane, and trial registries including ClinicalTrials.gov. METHODS OF STUDY SELECTION: We conducted an electronic search of research articles from 1966 to January 2017 for randomized controlled trials (RCTs), prospective cohort, and retrospective cohort studies of negative pressure wound therapy compared with standard dressing after cesarean delivery among obese women...
November 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28993006/promoting-sunscreen-use-and-sun-protective-practices-in-ncaa-athletes-impact-of-sunsport-educational-intervention-for-student-athletes-athletic-trainers-and-coaches
#18
Mina S Ally, Susan M Swetter, Kelsey E Hirotsu, Justin Gordon, David Kim, Ashley Wysong, Lindsy Donnelly, Shufeng Li, Kristin M Nord
BACKGROUND: Student-athletes (SAs) have an increased skin cancer risk on account of significant ultraviolet exposure; however, their sun-protective practices are suboptimal. A novel program, Stanford University Network for Sun Protection, Outreach, Research, and Teamwork (SUNSPORT), was designed to target SAs, coaches, and athletic trainers (ATs). OBJECTIVE: To measure the impact of educational intervention on sun protection beliefs and practices of SAs. METHODS: A survey of sun protection beliefs and practices was administered to National Collegiate Athletic Association athletes before and after intervention...
October 6, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28990864/a-frosty-disagreement-john-tyndall-james-david-forbes-and-the-early-formation-of-the-x-club
#19
Nanna Katrine Lüders Kaalund
How do glaciers move? This seemingly straightforward question provided the backdrop for a heated debate between the physicists John Tyndall (1820-1893) and James David Forbes (1809-1868) in the late 1850s and early 1860s. Forbes described the motion of glaciers as that of a viscous fluid. After visiting the Alps, Tyndall proposed an alternative theory that combined fracture and regelation. The glacial controversy ensued. Yet the debate was never simply about whether glaciers moved like honey, or if they moved by continuously breaking and re-attaching...
October 9, 2017: Annals of Science
https://www.readbyqxmd.com/read/28988203/firearms-training-what-is-actually-taught
#20
David Hemenway, Steven Rausher, Pina Violano, Toby A Raybould, Catherine W Barber
INTRODUCTION: Firearm safety instructors and public health professionals are natural allies in the quest to prevent firearm injuries. We audited basic firearm classes to provide information that can help familiarise public health professionals and others with the content covered. METHODS: With the advice of expert instructors, we created an audit form. Volunteers audited 20 basic firearm classes in seven north-eastern states. RESULTS: All trainers covered a wide variety of safety issues...
October 7, 2017: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
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