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David Allis

Gail Ewing, Clarissa Penfold, John Benson, Ravi Mahadeva, Sophie Howson, Julie Burkin, Sara Booth, Roberta Lovick, David Gilligan, Christopher Todd, Morag Farquhar
CONTEXT: Carers' needs in advanced disease, and specifically in relation to breathlessness, are well evidenced. Publications on educational interventions for carers of patients with advanced disease which focus on symptoms are scarce and absent for breathlessness. OBJECTIVES: To establish current education provided by clinicians for carers of patients with breathlessness in advanced disease, views about educating carers about breathlessness and relevant outcomes for a future randomised controlled trial (RCT) of an educational intervention for carers...
October 7, 2016: Journal of Pain and Symptom Management
David McBride, Kirsten Lovelock, Daniel Shepherd, Kim Dirks, David Welch, Andrew Gray
OBJECTIVE: The New Zealand Ministry of Health responded to community concern about dioxin exposure during on-site remediation of a pesticide-contaminated rural area by commissioning this exposed-referent study of serum dioxins and health in local residents. METHODS: All 200 residents were eligible, with age and sex matching to demographically comparable referents. Face-to-face interviews included questions on health status, health-related quality of life (HRQOL) and perceptions about community consultation...
October 2016: Australian and New Zealand Journal of Public Health
Eliza G Miller, Caryl A Nowson, David W Dunstan, Deborah A Kerr, Vicky Solah, David Menzies, Robin M Daly
BACKGROUND: Recruitment of participants into long-term community-based lifestyle intervention trials, particularly adults with a chronic disease, is often slow and challenging. Currently there is limited data on successful recruitment strategies suitable for older adults with type 2 diabetes into community-based exercise and nutrition programs, and no information on cost estimates associated with such recruitment. The aim of this report is to describe the recruitment strategies used and the success of each approach in recruiting older adults with type 2 diabetes into a 6-month community-based exercise and nutritional supplementation randomised controlled trial (RCT)...
September 26, 2016: Trials
David Sibbritt, Romy Lauche, Tobias Sundberg, Wenbo Peng, Craig Moore, Alex Broom, Emma Kirby, Jon Adams
BACKGROUND: Back pain is a common, disabling and costly disorder for which patients often consult with a wide range of health practitioners. Unfortunately, no research to date has directly examined the association between the severity of back pain and back pain sufferers' choice of whom and in what order to consult different health practitioners. METHODS: This is a sub-study of the large nationally representative Australian Longitudinal Study on Women's Health (ALSWH)...
2016: BMC Musculoskeletal Disorders
Charles Boelen, David Pearson, Arthur Kaufman, James Rourke, Robert Woollard, David C Marsh, Trevor Gibbs
Health systems worldwide are confronted with challenges due to increased demand from their citizens, an aging population, a variety of health risks and limited resources. Key health stakeholders, including academic institutions and medical schools, are urged to develop a common vision for a more efficient and equitable health sector. It is in this environment that Boelen and Heck defined the concept of the "Social Accountability of Medical Schools" - a concept that encourages schools to produce not just highly competent professionals, but professionals who are equipped to respond to the changing challenges of healthcare through re-orientation of their education, research and service commitments, and be capable of demonstrating a positive effect upon the communities they serve...
September 9, 2016: Medical Teacher
Ben Antebi, Avi Benov, Elizabeth A Mann-Salinas, Tuan D Le, Leopoldo C Cancio, Joseph C Wenke, Haim Paran, Avraham Yitzhak, Bader Tarif, Kirby R Gross, David Dagan, Elon Glassberg
BACKGROUND: As new conflicts emerge and enemies evolve, military medical organizations worldwide must adopt the 'lessons learned'. In this study we describe roles of care (ROC) deployed and injuries sustained by both US and Israeli militaries during recent conflicts. The purpose of this collaborative work is facilitate exchange of medical data among allied forces in order to advance military medicine and facilitate strategic readiness for future military engagements that may involve less predictable situations of evacuation and care, such as prolonged field care...
September 16, 2016: Journal of Trauma and Acute Care Surgery
Clare L Brown, Helen L Mulcaster, Katherine L Triffitt, Dean F Sittig, Joan S Ash, Katie Reygate, Andrew K Husband, David W Bates, Sarah P Slight
OBJECTIVE: To understand the different types and causes of prescribing errors associated with computerized provider order entry (CPOE) systems, and recommend improvements in these systems. MATERIALS AND METHODS: We conducted a systematic review of the literature published between January 2004 and June 2015 using three large databases: the Cumulative Index to Nursing and Allied Health Literature, Embase, and Medline. Studies that reported qualitative data about the types and causes of these errors were included...
August 30, 2016: Journal of the American Medical Informatics Association: JAMIA
Susan Young, Marios Adamou, Philip Asherson, David Coghill, Bill Colley, Gisli Gudjonsson, Chris Hollis, Jane McCarthy, Ulrich Müller, Moli Paul, Mark Pitts, Muhammad Arif
The aim of this consensus statement was to discuss transition of patients with ADHD from child to adult healthcare services, and formulate recommendations to facilitate successful transition. An expert workshop was convened in June 2012 by the UK Adult ADHD Network (UKAAN), attended by a multidisciplinary team of mental health professionals, allied professionals and patients. It was concluded that transitions must be planned through joint meetings involving referring/receiving services, patients and their families...
2016: BMC Psychiatry
David R Price, Mark E Mikkelsen, Craig A Umscheid, Ehrin J Armstrong
OBJECTIVE: The relationship between neuromuscular blocking agents and neuromuscular dysfunction acquired in critical illness remains unclear. We examined the association between neuromuscular blocking agents and ICU-acquired weakness, critical illness polyneuropathy, and critical illness myopathy. DATA SOURCES: PubMed, EMBASE, Web of Science, Cochrane Central Register of Controlled Trials, Cumulative Index of Nursing and Allied Health Literature, and bibliographies of included studies were searched from database inception until September 24, 2015...
November 2016: Critical Care Medicine
David Olusoga Ogbolu, Armstrong Oyebode Alli, Michael C Anorue, Oluwole Adebayo Daini, Afolabi Oluwadun
BACKGROUND: Until recently, mechanisms of resistance to quinolones in Gram-negative bacteria were believed to be only chromosome encoded. However, emergence of plasmid-mediated quinolone resistance (PMQR) has been reported worldwide. AIM: This study investigated distribution of PMQR in Gram-negative bacteria from a tertiary hospital in eastern part of Nigeria. MATERIALS AND METHODS: Seventy-one nonduplicate Gram-negative bacterial isolates of eight species were analyzed for antimicrobial susceptibility, genotypic detection of various PMQRs, typed by random amplified polymorphic DNA (RAPD) and analysis of plasmids present, including replicon typing...
July 2016: Indian Journal of Pathology & Microbiology
Diane M Damez-Werno, HaoSheng Sun, Kimberly N Scobie, Ningyi Shao, Jaclyn Rabkin, Caroline Dias, Erin S Calipari, Ian Maze, Catherine J Pena, Deena M Walker, Michael E Cahill, Ramesh Chandra, Amy Gancarz, Ezekiell Mouzon, Joseph A Landry, Hannah Cates, Mary-Kay Lobo, David Dietz, C David Allis, Ernesto Guccione, Gustavo Turecki, Paola Defilippi, Rachael L Neve, Yasmin L Hurd, Li Shen, Eric J Nestler
Repeated cocaine exposure regulates transcriptional regulation within the nucleus accumbens (NAc), and epigenetic mechanisms-such as histone acetylation and methylation on Lys residues-have been linked to these lasting actions of cocaine. In contrast to Lys methylation, the role of histone Arg (R) methylation remains underexplored in addiction models. Here we show that protein-R-methyltransferase-6 (PRMT6) and its associated histone mark, asymmetric dimethylation of R2 on histone H3 (H3R2me2a), are decreased in the NAc of mice and rats after repeated cocaine exposure, including self-administration, and in the NAc of cocaine-addicted humans...
August 23, 2016: Proceedings of the National Academy of Sciences of the United States of America
Clare L Brown, Katie Reygate, Ann Slee, Jamie J Coleman, Sarah K Pontefract, David W Bates, Andrew K Husband, Neil Watson, Sarah P Slight
OBJECTIVES: A key element of the implementation and ongoing use of an electronic prescribing (ePrescribing) system is ensuring that users are, and remain, sufficiently trained to use the system. Studies have suggested that insufficient training is associated with suboptimal use. However, it is not clear from these studies how clinicians are trained to use ePrescribing systems or the effectiveness of different approaches. We sought to describe the various approaches used to train qualified prescribers on ePrescribing systems and to identify whether users were educated about the pitfalls and challenges of using these systems...
August 4, 2016: International Journal of Pharmacy Practice
Shuang Yang, Xiangdong Zheng, Chao Lu, Guo-Min Li, C David Allis, Haitao Li
High-frequency point mutations of genes encoding histones have been identified recently as novel drivers in a number of tumors. Specifically, the H3K36M/I mutations were shown to be oncogenic in chondroblastomas and undifferentiated sarcomas by inhibiting H3K36 methyltransferases, including SETD2. Here we report the crystal structures of the SETD2 catalytic domain bound to H3K36M or H3K36I peptides with SAH (S-adenosylhomocysteine). In the complex structure, the catalytic domain adopts an open conformation, with the K36M/I peptide snuggly positioned in a newly formed substrate channel...
July 15, 2016: Genes & Development
Giovanni Gambaro, Emanuele Croppi, Fredric Coe, James Lingeman, Orson Moe, Elen Worcester, Noor Buchholz, David Bushinsky, Gary C Curhan, Pietro Manuel Ferraro, Daniel Fuster, David S Goldfarb, Ita Pfeferman Heilberg, Bernard Hess, John Lieske, Martino Marangella, Dawn Milliner, Glen M Preminger, Jose' Manuel Reis Santos, Khashayar Sakhaee, Kemal Sarica, Roswitha Siener, Pasquale Strazzullo, James C Williams
BACKGROUND: Recently published guidelines on the medical management of renal stone disease did not address relevant topics in the field of idiopathic calcium nephrolithiasis, which are important also for clinical research. DESIGN: A steering committee identified 27 questions, which were proposed to a faculty of 44 experts in nephrolithiasis and allied fields. A systematic review of the literature was conducted and 5216 potentially relevant articles were selected; from these, 407 articles were deemed to provide useful scientific information...
July 25, 2016: Journal of Nephrology
David Olusoga Ogbolu, Oyebode Terry Alli, Itunu Odeleye, Adeolu S Oluremi
OBJECTIVE: To determine the prevalence of viral haemoparasites in prospective Nigerian blood donors. METHODS: Ethical clearance was obtained and informed consent questionnaires were distributed to blood donors to obtain their demographical data. A total of 186 blood donors from LAUTECH Teaching Hospital, Osogbo were tested for hepatitis A virus (HAV), hepatitis B virus (HBV) and hepatitis C virus (HCV) using rapid test kit and enzyme linked immunosorbent assay. RESULTS: The highest prevalence of blood transmitted infections was 182 (97...
July 2016: Asian Pacific Journal of Tropical Medicine
Dorit Naot, Maureen Watson, Karen E Callon, Donna Tuari, David S Musson, Ally J Choi, Dharshini Sreenivasan, Justin Fernandez, Pao Ting Tu, Michelle Dickinson, Greg D Gamble, Andrew Grey, Jillian Cornish
A positive association between fat and bone mass is maintained through a network of signaling molecules. Clinical studies found that the circulating levels of adiponectin, a peptide secreted from adipocytes, are inversely related to visceral fat mass and bone mineral density, and it has been suggested that adiponectin contributes to the coupling between fat and bone. Our study tested the hypothesis that adiponectin affects bone tissue by comparing the bone phenotype of wild-type and adiponectin-knockout (APN-KO) female mice between the ages of 8-37 weeks...
September 2016: Endocrinology
David Jackson, Gail Roberts, Min Lin Wu, Rosemary Ford, Colleen Doyle
BACKGROUND: The objective of this review was to assess the effectiveness of interventions delivered by telephone, internet or combined formats to support carers of community dwelling people living with Alzheimer's Disease, vascular dementia or mixed dementia. METHOD: English language literature published up to 2016 was searched. The initial search included: MEDLINE, Cumulative Index to Nursing and Allied Health (CINAHL), and PsycINFO. A second search was conducted using Medical Subject Headings (MeSH) and keywords for eight databases...
September 2016: Archives of Gerontology and Geriatrics
Ally Olotu, Gregory Fegan, Juliana Wambua, George Nyangweso, Amanda Leach, Marc Lievens, David C Kaslow, Patricia Njuguna, Kevin Marsh, Philip Bejon
BACKGROUND: The candidate malaria vaccine RTS,S/AS01 is being evaluated in order to inform a decision regarding its inclusion in routine vaccination schedules. METHODS: We conducted 7 years of follow-up in children who had been randomly assigned, at 5 to 17 months of age, to receive three doses of either the RTS,S/AS01 vaccine or a rabies (control) vaccine. The end point was clinical malaria (temperature of ≥37.5°C and infection with Plasmodium falciparum of >2500 parasites per cubic millimeter)...
June 30, 2016: New England Journal of Medicine
David O Riordan, Kieran A Walsh, Rose Galvin, Carol Sinnott, Patricia M Kearney, Stephen Byrne
OBJECTIVE: To evaluate studies of pharmacist-led interventions on potentially inappropriate prescribing among community-dwelling older adults receiving primary care to identify the components of a successful intervention. DATA SOURCES: An electronic search of the literature was conducted using the following databases from inception to December 2015: PubMed, Embase, Cumulative Index to Nursing and Allied Health Literature, MEDLINE (through Ovid), Trip, Centre for Reviews and Dissemination databases, Cochrane Database of Systematic Reviews, ISI Web of Science, ScienceDirect, ClinicalTrials...
2016: SAGE Open Medicine
Shabbir Lalji, Jeremiah M Ngondi, Narjis G Thawer, Autman Tembo, Renata Mandike, Ally Mohamed, Frank Chacky, Charles D Mwalimu, George Greer, Naomi Kaspar, Karen Kramer, Bertha Mlay, Kheri Issa, Jane Lweikiza, Anold Mutafungwa, Mary Nzowa, Ritha A Willilo, Waziri Nyoni, David Dadi, Mahdi M Ramsan, Richard Reithinger, Stephen M Magesa
Tanzania successfully scaled up coverage of long-lasting insecticidal nets (LLINs) through mass campaigns. To sustain these gains, a school-based approach was piloted in the country's Southern Zone starting in 2013, called the School Net Program 1 (SNP1). We report on the design, implementation, monitoring, and outputs of the second round (SNP2) undertaken in 2014. SNP2 was conducted in all schools in Lindi, Mtwara, and Ruvuma regions, targeting students in primary (Standards 1, 3, 5, and 7) and secondary (Forms 2 and 4) schools and all teachers...
June 20, 2016: Global Health, Science and Practice
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