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treatment of endometrial stromal sarcoma

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https://www.readbyqxmd.com/read/28738297/endometrial-stromal-sarcoma-a-retropsective-analysis-of-factors-affecting-recurrence
#1
Reshu Agarwal, Anupama Rajanbabu, Indu R Nair, Chandramouli Satish, Georgeena Jose, U G Unikrishnan
OBJECTIVE: To assess the factors associated with disease free survival and overall survival in endometrial stromal sarcoma (ESS). METHODS: This was a single institution retrospective analysis done at Amrita Institute of Medical Sciences. Records from January 2005 to October 2016 were analysed and 42 patients with ESS were identified. Clinicopathological, surgical management, adjuvant treatment and outcome data were collected. Disease free and overall survivals were analysed using Kaplan-Meier method and compared using log rank test...
July 14, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28596015/low-grade-and-high-grade-endometrial-stromal-sarcoma-a-national-cancer-database-study
#2
Brandon-Luke L Seagle, Arunima Shilpi, Samuel Buchanan, Chelain Goodman, Shohreh Shahabi
OBJECTIVE: To provide refined prognostic information from large cohorts of women with low-grade or high-grade endometrial stromal sarcoma (ESS). METHODS: We performed an observational retrospective cohort analysis of women diagnosed with low-grade or high-grade ESS from the 1998-2013 National Cancer Database. Kaplan-Meier and multivariable accelerated failure time survival analyses were performed to identify prognostic factors after multiple imputation of missing data...
August 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28588782/rapidly-progressing-large-cell-neuroendocrine-carcinoma-arising-from-the-uterine-corpus-a-case-report-and-review-of-the-literature
#3
Aya Kobayashi, Tamaki Yahata, Sakiko Nanjo, Mika Mizoguchi, Madoka Yamamoto, Yasushi Mabuchi, Shigetaka Yagi, Sawako Minami, Kazuhiko Ino
Large-cell neuroendocrine carcinoma (LCNEC) is a high-grade neuroendocrine tumor. LCNECs arising from the genital organs are highly malignant and rare, with <20 cases of LCNEC developing from the uterine endometrium reported to date. We herein present the case of a patient with LCNEC of the endometrium. The patient was a 52-year-old woman, who exhibited lower abdominal pain and rapid uterine enlargement during outpatient treatment for uterine myoma. The endometrial biopsy suggested a diagnosis of poorly differentiated carcinoma or carcinosarcoma...
June 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28498251/undiagnosed-uterine-sarcomas-identified-during-surgery-for-presumed-leiomyoma-at-a-national-tertiary-hospital-in-thailand-a-10-year-review
#4
Irene Ruengkhachorn, Nisarat Phithakwatchara, Katika Nawapun, Suchanan Hanamornroongruang
OBJECTIVES: The aim of this study was to evaluate the rate, clinical characteristics, and survival outcomes of an undiagnosed uterine malignancy in patients who underwent surgical treatment for presumed leiomyomas. METHODS: Medical records of patients who underwent surgical treatment for presumed leiomyomas, from January 2004 to September 2013, were retrospectively reviewed, and the data were followed until September 2016. Demographic data, tumor characteristics, oncologic treatment, and response rate were analyzed by descriptive statistics...
June 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28494324/an-unexpected-diagnosis-of-primary-omental-endometrial-stromal-sarcoma-in-a-patient-with-acute-right-abdominal-pain-a-case-report-and-review-of-literature
#5
Vered Buchholz, George Kiroff, Markus Trochsler, Harsh Kanhere
INTRODUCTION: Extrauterine Endometrial Stromal Sarcoma (EESS) is an extremely rare mesenchymal tumour that simulates other pathologies, and therefore poses a diagnostic challenge. This report outlines a case of EESS arising from the greater omentum mimicking a colonic tumour, with review of literature. PRESENTATION OF CASE: A 47-year-old woman, with history of hysterectomy for menorrhagia and hormone replacement therapy (HRT), presented with right sided abdominal pain and localized peritonism...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28464838/primary-extragenital-endometrial-stromal-sarcoma-of-the-lung-first-reported-case-and-review-of-literature
#6
Lara Alessandrini, Francesco Sopracordevole, Giulio Bertola, Simona Scalone, Martina Urbani, Gianmaria Miolo, Tiziana Perin, Fabrizio Italia, Vincenzo Canzonieri
BACKGROUND: Endometrial stromal sarcomas arising in extrauterine and extraovarian sites, in the absence of a primary uterine lesion are quite rare, especially in the absence of endometriosis. They usually present as an abdominal or pelvic mass lesion. CASE PRESENTATION: In 2007, a 45-year-old woman underwent total hysterectomy for in situ squamous cell carcinoma of the cervix. In 2014, an upper left pulmonary lobectomy was performed for a mass, which was provisionally diagnosed as primary carcinosarcoma of the lung...
May 2, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/28403089/clinicopathological-characteristics-and-treatment-strategies-for-patients-with-low-grade-endometrial-stromal-sarcoma
#7
REVIEW
Ran Cui, Fang Yuan, Yue Wang, Xia Li, Zhenyu Zhang, Huimin Bai
To investigate and evaluate the clinicopathological characteristics and treatment strategies for patients with low-grade endometrial stromal sarcoma (LG-ESS).The medical records of LG-ESS patients who were treated at 2 cancer referral centers from January 2005 to December 2015 were retrospectively reviewed.Twenty patients with LG-ESS met the inclusion criteria and were included in this analysis. Hysterectomy with bilateral salpingo-oophorectomy was the mainstay of surgery. Lymphadenectomy was performed in 12 (60%) cases, and no positive nodes were identified...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28400352/frequency-of-uterine-sarcomas-in-patients-admitted-for-uterine-fibroid-surgery
#8
Liselotte Mettler, Nicolai Maass, Khulkar Abdusattarova, Astrid Dempfle, Ibrahim Alkatout
OBJECTIVE: To estimate the frequency of unsuspected uterine sarcoma identified postoperatively in women undergoing surgery for presumed benign uterine fibroids at a single university hospital. MATERIAL AND METHODS: This was a retrospective single-center study; the records of all 2275 patients with uterine fibroids and uterine sarcomas from 2003 to 2015 were reviewed. Descriptive statistics were used to analyze demographic and clinical characteristics. To calculate confidence intervals (CIs), the Clopper-Pearson Exact method was applied...
June 1, 2017: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/28390819/ywhae-rearranged-high-grade-endometrial-stromal-sarcoma-two-center-case-series-and-response-to-chemotherapy
#9
MULTICENTER STUDY
Matthew L Hemming, Andrew J Wagner, Marisa R Nucci, Sarah Chiang, Lu Wang, Martee L Hensley, Suzanne George
OBJECTIVES: YWHAE-rearranged high-grade endometrial stromal sarcoma (HG-ESS) is a rare, recently defined uterine sarcoma harboring t(10;17)(q22;p13) resulting in YWHAE-NUTM2A/B fusion. Chemotherapy sensitivity of metastatic YWHAE-rearranged HG-ESS is unknown. We reviewed the response to chemotherapy in women with YWHAE-rearranged HG-ESS to provide guidance for clinical management. METHODS: We retrospectively identified patients diagnosed with YWHAE-rearranged HG-ESS who received treatment for metastatic disease at our institutions...
June 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28353387/recent-developments-in-surgical-pathology-of-the-uterine-corpus
#10
REVIEW
Krisztina Z Hanley, George G Birdsong, Marina B Mosunjac
There have been several updates recently on the classification of uterine tumors. Endometrial carcinomas have traditionally been divided into 2 types, but some are difficult to classify and do not fit readily into either of the currently recognized categories. The Cancer Genome Atlas Research Network has recently defined 4 new categories of endometrial cancer on the basis of mutational spectra, copy number alteration, and microsatellite instability, which might provide independent prognostic information beyond established risk factors...
April 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28331900/a-recurrent-endometrial-stromal-sarcoma-harbors-the-novel-fusion-jazf1-bcorl1
#11
Allison J Allen, Siraj M Ali, Kyle Gowen, Julia A Elvin, Tanja Pejovic
•Genomic alterations may improve diagnostic certainty and subsequent treatment of endometrial stromal sarcoma.•Novel JAZF1-BCORL1 mutation was identified.•Targeted therapeutics to down-stream targets may improve survival benefit in these patients.
May 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28299760/uterine-sarcomas-the-latest-approaches-for-these-rare-but-potentially-deadly-tumors
#12
REVIEW
Jing-Yi Chern, Leslie R Boyd, Stephanie V Blank
Uterine sarcomas are rare malignant uterine neoplasms that are responsible for a large majority of uterine cancer-associated deaths. The subtypes include leiomyosarcomas, endometrial stromal tumors, and adenosarcomas. Standard treatment includes complete surgical resection. Adjuvant treatment with chemotherapy, hormonal therapy, or radiation may be considered in patients with high-risk disease. However, because the ability of adjuvant treatment to improve overall survival in patients with uterine sarcomas is unclear, there is no standard recommendation regarding adjuvant therapy...
March 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/28246921/magnetic-resonance-imaging-features-of-uterine-sarcoma-and-mimickers
#13
REVIEW
Matthias Barral, Vinciane Placé, Raphaël Dautry, Sandra Bendavid, Françoise Cornelis, Romain Foucher, Youcef Guerrache, Philippe Soyer
Uterine myometrial tumors are predominantly benign conditions that affect one-third of women and represent the main indication for hysterectomy. Preoperative imaging is of utmost importance for characterization and for precise mapping of myometrial tumors to best guide therapeutic strategy. New minimally invasive therapeutic strategies including morcellation, myolysis, uterine artery embolization and image-guided radiofrequency or focused ultrasound ablation have been developed for the treatment of uterine leiomyoma...
June 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28002210/european-society-of-gynecological-oncology-statement-on-fibroid-and-uterine-morcellation
#14
Michael J Halaska, Dimitrios Haidopoulos, Frédéric Guyon, Philippe Morice, Ignacio Zapardiel, Vesna Kesic
Recently, there has been an intense discussion about the issue of fibroid and uterine morcellation in relation to the risk of unrecognized uterine sarcoma spread. Morcellation can negatively influence the prognosis of patients, and transecting the specimen into pieces prevents the pathologist from performing proper disease staging. Many societies have published their statements regarding this issue. The European Society for Gynecological Oncology has established a working group of clinicians involved in diagnostics and treatment of oncogynecological patients to provide a statement from the oncological point of view...
January 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27895740/letrozole-as-second-line-hormonal-treatment-for-recurrent-low-grade-endometrial-stromal-sarcoma-a-case-report-and-review-of-the-literature
#15
Kohei Nakamura, Kentaro Nakayama, Masako Ishikawa, Noriyoshi Ishikawa, Hiroshi Katagiri, Atsuko Katagiri, Tomoka Ishibashi, Emi Sato, Kohji Iida, Razia Sultana, Satoru Kyo
Low-grade endometrial stromal sarcoma (LGESS) is a rare malignancy. The tumor is reportedly responsive to hormonal therapy, most commonly with medroxyprogesterone acetate (MPA), but the effectiveness of aromatase inhibitors for recurrent LGESS remains unclear. The present study reports a case of stage IC LGESS presenting with abnormal uterine bleeding, and also provides a review of the literature. Following a total abdominal hysterectomy and bilateral salpingo-oophorectomy, MPA therapy was initiated; treatment was successful, but discontinued 19 months later due to disruptive side effects...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27869363/is-the-memorial-sloan-kettering-cancer-centre-mskcc-sarcoma-nomogram-useful-in-an-asian-population
#16
Deanna Wan Jie Ng, Grace Hwei Ching Tan, Claramae Shulyn Chia, Cindy Xindi Lim, Soo Khee Chee, Richard Hong Hui Quek, Mohamad Farid, Melissa Ching Ching Teo
AIM: A nomogram for prediction of 12-year sarcoma-specific survival has been developed based on patients with soft tissue sarcomas treated in Memorial Sloan Kettering Cancer Centre (MSKCC). We aim to evaluate the predictive accuracy of the MSKCC sarcoma nomogram in a cohort of patients treated at an Asian institution. This has not been validated in an Asian population and thus its universal applicability remains unproven. MATERIALS AND METHODS: Between 1990 and 2013, 840 adult patients underwent treatment for primary soft tissue sarcoma (STS) at the National Cancer Centre Singapore...
November 21, 2016: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27818947/a-case-of-retroperitoneal-metastases-that-occur-14-years-after-surgery
#17
Masjensen Argadjendra, Nariman Ahmadi, Celi Varol
Endometrial Stromal Sarcomas are rare malignant tumours of the uterus. We report the case of incidental finding of Low-Grade Endometrial Stromal Sarcoma (LGESS) that metastasized to the retroperitoneum 14 years after the original surgery in a 72-year-old woman. The patient underwent a laparotomy and excision of all tumour nodules. Considering the common recurrence of and slow growing nature of LGESS, appropriate treatment options like surgical excision and life-long follow up should be considered.
November 2016: Urology Case Reports
https://www.readbyqxmd.com/read/27736798/fertility-sparing-surgery-for-patients-with-low-grade-endometrial-stromal-sarcoma
#18
Weimin Xie, Dongyan Cao, Jiaxin Yang, Xuan Jiang, Keng Shen, Lingya Pan, Huifang Huang, Jinghe Lang, Yan You, Jie Chen
PURPOSE: To assess the clinical outcomes and fertility of young women with stage I low-grade endometrial stromal sarcoma (ESS) treated with fertility-sparing surgery. RESULTS: Seventeen patients with stage I low-grade ESS (stage IA, n = 6; stage IB, n = 11) were entered into this study. Adjuvant hormone therapy was administered to 15 (88.2%) patients. At a median follow-up of 39 months (range, 4-106 months), 10 (58.8%) patients developed recurrence. All 10 patients had stage IB disease; among them, the first recurrence limited to the uterus was observed in 6 patients...
February 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/27629136/systemic-therapy-for-endometrial-stromal-sarcomas-current-treatment-options
#19
Krystyna Serkies, Ewa Pawłowska, Jacek Jassem
Uterine endometrial stromal sarcomas including true low-grade endometrial stromal sarcoma (LG-ESS) and high-grade (HG-ESS) or undifferentiated endometrial sarcoma (UES) constitute a group of rare, aggressive malignancies. Most LG-ESSs express steroid receptors. Surgery is the principal primary therapy for endometrial stromal sarcomas and should be considered in all cases. These malignancies are relatively radio- and chemoresistant. Chemotherapy is used in recurrent and advanced HG-ESS and UES. Currently, the combination of gemcitabine and docetaxel is considered the most effective regimen, but at the expense of substantial toxicity...
2016: Ginekologia Polska
https://www.readbyqxmd.com/read/27618565/malignant-transformation-of-vaginal-endometriosis-a-review-of-literature
#20
REVIEW
Mauro Cozzolino, Dimitrios Nasioudis, Giovanni Sisti, Maria Elisabetta Coccia
BACKGROUND: The study aimed to examine all available evidence regarding primary vaginal cancer arising from endometriosis from an evidence-based perspective. METHODS: A literature search in Medline and EMBASE databases was conducted. The following key words were employed: 'vaginal cancer' AND 'endometriosis malignant transformation' OR 'endometriosis'. RESULTS: A total of 23 eligible studies were identified and included in the present review providing information for 37 patients...
2017: Gynecologic and Obstetric Investigation
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