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Troponin Sensitive Diagnosis

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https://www.readbyqxmd.com/read/29663841/novel-heart-failure-biomarkers-why-do-we-fail-to-exploit-their-potential
#1
Arnold Piek, Weijie Du, Rudolf A de Boer, Herman H W Silljé
Plasma biomarkers are useful tools in the diagnosis and prognosis of heart failure (HF). In the last decade, numerous studies have aimed to identify novel HF biomarkers that would provide superior and/or additional diagnostic, prognostic, or stratification utility. Although numerous biomarkers have been identified, their implementation in clinical practice has so far remained largely unsuccessful. Whereas cardiac-specific biomarkers, including natriuretic peptides (ANP and BNP) and high sensitivity troponins (hsTn), are widely used in clinical practice, other biomarkers have not yet proven their utility...
April 17, 2018: Critical Reviews in Clinical Laboratory Sciences
https://www.readbyqxmd.com/read/29658868/serum-levels-of-mir-155-mir-326-and-mir-133b-as-early-diagnostic-biomarkers-for-the-detection-of-human-acute-heart-allograft-rejection-in-comparison-with-serum-cardiac-troponin-t
#2
Aghil Esmaeili-Bandboni, Jamshid Bagheri, Ali Reza Bakhshandeh, Javad Mohammadnejad, Esmaeil Sadroddiny
BACKGROUND: Acute heart allograft rejection occurs as a result of antibody-mediated rejection that presents during the first month after transplantation. Finding a non-invasive biomarker is essential for diagnosis of heart allograft rejection. In this research, we intended to compare expression levels of several microRNAs across cardiac troponin T levels between rejected patients (who died before one month following transplantation), non-rejected patients (who survived for at least one month after transplantation), and non-transplanted patients (CABG surgery patients)...
March 12, 2018: Heart Surgery Forum
https://www.readbyqxmd.com/read/29627229/the-use-of-cell-cycle-arrest-biomarkers-in-the-early-detection-of-acute-kidney-injury-is-this-the-new-renal-troponin
#3
Luis M Ortega, Michael Hueng
Acute kidney injury (AKI) has a high prevalence in critical care patients. Early detection might prevent patients from developing chronic kidney disease and requirement for renal replacement therapy. If we compare AKI with acute coronary syndrome, in which an increase in cardiac troponin may trigger early diagnosis and therapeutic intervention, we could extrapolate a similar technique in patients with early AKI without changes in urinary frequency or serum creatinine. The objective is to identify biomarker-positive, creatinine-negative patients that would allow therapeutic interventions to be initiated before finding changes in serum creatinine, preventing kidney damage...
April 4, 2018: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/29622975/ischemia-modified-albumin-ima-in-acute-coronary-syndrome-acs-and-left-bundle-branch-block-lbbb-does-it-make-the-difference
#4
Mohamed Abdel Kader Abdel Wahab
Background: Management of patients with a suspected ACS and LBBB is a challenge to the clinician. Aim: To detect the ability of IMA to exclude myocardial ischemia in suspected patients with ACS and LBBB. Material and methods: A total of 68 patients with suspected ACS and LBBB (group I) and another twenty patients age and sex matched known to have LBBB with normal coronary angiography (group II) were included in this study and subjected to: routine laboratory tests, 12 lead ECG, echocardiography, and measurement of serum troponin I (TnI) and IMA (measured by ELISA)...
September 2017: The Egyptian heart journal: (EHJ): official bulletin of the Egyptian Society of Cardiology
https://www.readbyqxmd.com/read/29619842/high-sensitivity-cardiac-troponin-t-for-diagnosis-of-nstemi-in-the-elderly-emergency-department-patient-a-clinical-cohort-study
#5
Dorothee Riedlinger, Martin Möckel, Christian Müller, Fabian Holert, Julia Searle, Johannes von Recum, Anna Slagman
PURPOSE: The aim of this study is to evaluate the impact of age on the diagnostic performance of high-sensitivity Troponin T (hsTnT) under routine conditions. MATERIAL AND METHODS: Data of 4,118 consecutive emergency department (ED) patients who underwent a routine TnTmeasurement between October 11th 2012 and November 30th 2013 were analyzed. Diagnostic accuracy of hsTnT was compared in four age categories (<50, 50-64, 65-74 ≥75 years of age) for different cut-off values...
April 5, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29589418/myocardial-injury-after-non-cardiac-surgery-a-perioperative-affair
#6
Viviana Miccichè, Cesare Baldi, Edoardo DE Robertis, Ornella Piazza
Myocardial injury after non cardiac surgery (MINS) is a rather new nosological entity and an unfortunately common perioperative complication. The diagnostic criteria for MINS, also indicated as isolated myocardi- al injury (IMI), are an elevated postoperative high sensitivity Troponin T (hsTnT level ranging between 20 and 65 ng/L with an absolute change of at least 5 ng/L or hsTnT level > 65 ng/L), in absence of symptoms and/or EKG findings suggestive of ischemia and without a non ischemic aetiology causing Troponin eleva- tion...
March 27, 2018: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29579246/high-sensitivity-cardiac-troponin-and-natriuretic-peptide-with-risk-of-lower-extremity-peripheral-artery-disease-the-atherosclerosis-risk-in-communities-aric-study
#7
Kunihiro Matsushita, Lucia Kwak, Chao Yang, Yuanjie Pang, Shoshana H Ballew, Yingying Sang, Ron C Hoogeveen, Bernard G Jaar, Elizabeth Selvin, Christie M Ballantyne, A Richey Sharrett, Aaron R Folsom, Gerardo Heiss, Josef Coresh, Alan T Hirsch
Aims: Cardiac troponin T (cTnT) is suggested as a predictor of amputation in patients with peripheral artery disease (PAD). However, cTnT-PAD association has not been systematically studied in a large study. This study evaluated the association of high-sensitivity cTnT (hs-cTnT) with PAD incidence and also explored whether natriuretic peptide (NT-proBNP), another representative cardiac marker, predicts PAD risk. Methods and results: Among 12 288 middle-aged adults, the associations of hs-cTnT and NT-proBNP with incident PAD (hospitalizations with PAD diagnosis or leg revascularization [cases with rest pain or tissue loss considered as critical limb ischaemia (CLI)]) were quantified with multivariable Cox regression models...
March 22, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29563381/diagnostic-approach-to-cardiac-involvement-in-idiopathic-inflammatory-myopathies
#8
Fei Chen, Yong Peng, Mao Chen
Cardiac involvement in idiopathic inflammatory myopathies (IIMs) attracts more attention than it ever did because of its morbidity and impact on worse prognosis, although the accurate information needs further epidemiological studies. Early identification and intervention for the diseased heart may help improve the clinical outcomes of IIMs with cardiac involvement. Cardiac troponin assays, allowing for sensitive detection of minor myocardium injury, may provide a new way for early detection for heart involvement in IIMs...
March 20, 2018: International Heart Journal
https://www.readbyqxmd.com/read/29550314/high-sensitivity-troponin-i-and-coronary-computed-tomography-in-symptomatic-outpatients-with-suspected-coronary-artery-disease-insights-from-the-promise-trial
#9
James L Januzzi, Sunil Suchindran, Adrian Coles, Maros Ferencik, Manesh R Patel, Udo Hoffmann, Geoffrey S Ginsburg, Pamela S Douglas
OBJECTIVES: The goal of this study was to examine associations between concentrations of high-sensitivity troponin I (hsTnI) (measured by using a single-molecule counting method) and obstructive coronary artery disease (CAD) in 1,844 stable, symptomatic outpatients with suspected CAD randomized to undergo coronary computed tomography angiography (CTA) in the PROMISE (Prospective Multicenter Imaging Study for Evaluation of Chest Pain) trial. BACKGROUND: Elevated concentrations of hsTnI are associated with CAD in patients with myocardial infarction...
March 9, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29538657/influence-of-impairment-in-renal-function-on-the-accuracy-of-high-sensitivity-cardiac-troponin-t-for-the-diagnosis-of-perioperative-myocardial-infarction-after-heart-valve-surgery
#10
Hector Cubero-Gallego, Maria Heredia-Rodriguez, Eduardo Tamayo
We aimed to assess the influence of impairment in renal function over the high-sensitivity cardiac troponin T (hs-cTnT) accuracy to diagnose perioperative myocardial infarction (MI) after heart valve surgery. Heart valve surgery was performed in 805 patients from June 2012 to January 2016. Patients with enzymatic curves of hs-cTnT suggestive of myocardial necrosis and electrocardiogram and/or transthoracic echocardiogram criteria were identified as patients with perioperative MI. Impairment in renal function was defined as a postoperative creatinine clearance <50 ml/min at 16 h after surgery and for at least 48 h...
March 12, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29531760/variability-of-cardiovascular-magnetic-resonance-cmr-t1-mapping-parameters-in-healthy-volunteers-during-long-term-follow-up
#11
Fabian Aus dem Siepen, Christian Baumgärtner, Matthias Müller-Henessen, Florian André, Daniel Messroghli, Marco Ochs, Johannes Riffel, Evangelos Giannitsis, Hugo A Katus, Matthias G Friedrich, Sebastian J Buss
Background: Myocardial T1 and extracellular volume (ECV) derived from cardiovascular MRIs are more and more widely accepted as important markers for diagnosis, risk prediction and monitoring of cardiac disease. Yet data regarding long-term stability of myocardial T1 mapping are lacking. The aim of this study was to investigate the long-term stability of native and postcontrast T1 mapping values in healthy volunteers. Methods: 18 strictly selected healthy volunteers (52±10 years, 12 men) were studied on a Philips Achieva 1...
2018: Open Heart
https://www.readbyqxmd.com/read/29479381/diagnostic-value-of-d-dimer-in-acute-myocardial-infarction-among-patients-with-suspected-acute-coronary-syndrome
#12
Hamidreza Reihani, Alireza Sepehri Shamloo, Assadollah Keshmiri
Background: The role of D-dimer as a diagnostic marker in myocardial infarction (MI) and acute coronary syndrome (ACS) is still a question. The aim of this study was to evaluate the diagnostic value of D-dimer in the diagnosis of AMI in patients suspected with ACS. Methods: This cross-sectional study was conducted on patients suspected with ACS. Serial standard 12-lead electrocardiogram (ECG), D-dimer, and troponin tests were done for all the patients. According to the examinations, ECG changes, and troponin, patients were allocated into two groups of MI and unstable angina (UA)...
February 2018: Cardiology Research
https://www.readbyqxmd.com/read/29476571/diagnostic-value-of-the-cardiac-electrical-biomarker-a-novel-ecg-marker-indicating-myocardial-injury-in-patients-with-symptoms-suggestive-of-non-st-elevation-myocardial-infarction
#13
Ivo Strebel, Raphael Twerenbold, Jasper Boeddinghaus, Roger Abächerli, Maria Rubini Giménez, Karin Wildi, Karin Grimm, Christian Puelacher, Patrick Badertscher, Zaid Sabti, Dominik Breitenbücher, Janina Jann, Farah Selman, Jeanne du Fay de Lavallaz, Nicolas Schaerli, Thomas Nestelberger, Claudia Stelzig, Michael Freese, Lukas Schumacher, Stefan Osswald, Christian Mueller, Tobias Reichlin
BACKGROUND: The cardiac electrical biomarker (CEB) is a novel electrocardiographic (ECG) marker quantifying the dipolar activity of the heart with higher levels indicating myocardial injury. METHODS: We prospectively enrolled 1097 patients presenting with suspected non-ST-elevation myocardial infarction (NSTEMI) to the emergency department (ED). Digital 12-lead ECGs were recorded at presentation and the CEB values were calculated in a blinded fashion. The final diagnosis was adjudicated by two independent cardiologists...
February 24, 2018: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/29444926/high-sensitivity-cardiac-troponin-i-and-the-diagnosis-of-coronary-artery-disease-in-patients-with-suspected-angina-pectoris
#14
Philip D Adamson, Amanda Hunter, Debbie M Madsen, Anoop S V Shah, David A McAllister, Tania A Pawade, Michelle C Williams, Colin Berry, Nicholas A Boon, Marcus Flather, John Forbes, Scott McLean, Giles Roditi, Adam D Timmis, Edwin J R van Beek, Marc R Dweck, Hans Mickley, Nicholas L Mills, David E Newby
BACKGROUND: We determined whether high-sensitivity cardiac troponin I can improve the estimation of the pretest probability for obstructive coronary artery disease (CAD) in patients with suspected stable angina. METHODS AND RESULTS: In a prespecified substudy of the SCOT-HEART trial (Scottish Computed Tomography of the Heart), plasma cardiac troponin was measured using a high-sensitivity single-molecule counting assay in 943 adults with suspected stable angina who had undergone coronary computed tomographic angiography...
February 2018: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/29434124/the-usefulness-and-limitations-of-point-of-care-cardiac-troponin-measurement-in-the-emergency-department
#15
Kenichiro Suzuki, Kimiaki Komukai, Kotaro Nakata, Renshi Kan, Yuhei Oi, Eri Muto, Yusuke Kashiwagi, Mitsutoshi Tominaga, Satoru Miyanaga, Tetsuya Ishikawa, Kenji Okuno, Masahiko Uzura, Michihiro Yoshimura
Objective This study was carried out to examine the usefulness of point-of-care (POC) cardiac troponin in diagnosing acute coronary syndrome (ACS) and to understand the limitations of a POC cardiac troponin I/T-based diagnoses. Methods Patients whose cardiac troponin levels were measured in the emergency department using a POC system (AQT System; Radiometer, Tokyo, Japan) between January and December 2016 were retrospectively examined (N=1449). Patients who were < 20 years of age or who were admitted with cardiopulmonary arrest were excluded...
February 9, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29432376/complementary-diagnostic-value-of-heart-type-fatty-acid-binding-protein-in-early-detection-of-acute-myocardial-infarction
#16
Maryam Sotoudeh Anvari, Mahsa Karimi, Akbar Shafiee, Mohammadali Boroumand, Ali Bozorgi, Reza Sedaghat, Arash Jalali
BACKGROUND: Heart-type fatty acid-binding protein (H-FABP) is a novel biomarker for myocardial injury. We compared the use of H-FABP with serum levels of cardiac troponin-T (cTnT) and creatine kinase-MB (CK-MB) in the diagnosis of patients suspicious to acute myocardial infarction (AMI). METHODS: From October 2013 to December 2014, 182 consecutive patients suspicious to acute coronary syndrome were enrolled in this study, who presented within the past 6 hours from the onset of symptoms...
March 2018: Critical Pathways in Cardiology
https://www.readbyqxmd.com/read/29432370/experiences-of-a-one-hour-algorithm-in-chest-pain-patients-with-a-nonelevated-troponin-t-at-presentation
#17
Anna Pettersson, Lina Ljung, Caroline Johansson, Umut Heilborn, Tomas Jernberg, Mats Frick, Kai M Eggers, Bertil Lindahl, Rikard Linder, Arne Martinsson, Per Svensson
BACKGROUND: We aimed to evaluate the use of a 1-hour measurement of high-sensitivity cardiac troponin T (hs-cTnT) in an emergency department (ED) population of chest pain patients with a nonelevated baseline hs-cTnT and to examine the prevalence of early dynamic changes in hs-cTnT and the association with admission rate, diagnosis, and outcome. METHODS: All patients with a chief complaint of chest pain presenting to the ED of Karolinska University Hospital, Solna, Sweden, from December 2014 to September 2015 who had a baseline hs-cTnT of ≤14 ng/L and a second value obtained within >30 to ≤90 minutes were followed for 30 days regarding admission, readmission, myocardial infarction (MI), and death...
March 2018: Critical Pathways in Cardiology
https://www.readbyqxmd.com/read/29414081/a-novel-label-free-photoelectrochemical-sensor-based-on-n-s-gqds-and-cds-co-sensitized-hierarchical-zn2sno4-cube-for-detection-of-cardiac-troponin-i
#18
Dawei Fan, Chunzhu Bao, Malik Saddam Khan, Chuanlei Wang, Yong Zhang, Qinze Liu, Xian Zhang, Qin Wei
A novel label-free photoelectrochemical (PEC) sensor based on graphene quantum dots doped with nitrogen and sulfur (N,S-GQDs) and CdS co-sensitized hierarchical Zn2SnO4 cube was fabricated to detect cardiac troponin I (cTnI). The unique hierarchical Zn2SnO4 cube was synthesized successfully by the solvothermal method, which has a large specific surface to load functional materials. N,S-GQDs nanoparticles were assembled to the surface of cubic Zn2SnO4 coated ITO electrode, which efficiently accelerated the electronic transition and improved photo-to-current conversion efficiency...
January 29, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29407114/objectively-measured-physical-activity-and-cardiac-biomarkers-a-cross-sectional-population-based-study-in-older-men
#19
Tessa J Parsons, Claudio Sartini, Paul Welsh, Naveed Sattar, Sarah Ash, Lucy T Lennon, S Goya Wannamethee, I-Min Lee, Peter H Whincup, Barbara J Jefferis
BACKGROUND: N-terminal pro-brain natriuretic peptide (NT-proBNP) and high sensitivity Troponin T (hsTnT) are markers of cardiac injury used in diagnosis of heart failure and myocardial infarction respectively, and associated with increased risk of cardiovascular disease. Since physical activity is protective against cardiovascular disease and heart failure, we investigated whether higher levels of physical activity, and less sedentary behaviour were associated with lower NT-proBNP and hsTnT...
March 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29407013/contemporary-emergency-department-management-of-patients-with-chest-pain-a-concise-review-and-guide-for-the-high-sensitivity-troponin-era
#20
REVIEW
James E Andruchow, Peter A Kavsak, Andrew D McRae
This article synthesizes current best evidence for the evaluation of patients with suspected acute coronary syndrome (ACS) using high-sensitivity troponin assays, enabling physicians to effectively incorporate them into practice. Unlike conventional assays, high-sensitivity assays can precisely measure blood cardiac troponin concentrations in the vast majority of healthy individuals, facilitating the creation of rapid diagnostic algorithms. Very low troponin concentrations on presentation accurately rule out acute myocardial infarction (AMI) and enable the discharge of approximately 20% of patients after a single test, whereas an additional 30%-40% of patients can be safely discharged after short-interval serial sampling in as little as 1 or 2 hours...
February 2018: Canadian Journal of Cardiology
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